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4. Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

Author

Zeeshan, Mohammad, Shilliday, Fiona, Liu, Tianyang, Abel, Steven, Mourier, Tobias, Ferguson, David JP, Rea, Edward, Stanway, Rebecca R, Roques, Magali, Williams, Desiree, Daniel, Emilie, Brady, Declan, Roberts, Anthony J, Holder, Anthony A, Pain, Arnab, Le Roch, Karine G, Moores, Carolyn A, and Tewari, Rita

Subjects
Microtubules, Animals, Mice, Inbred BALB C, Plasmodium, Oocysts, Malaria, Kinesin, Protozoan Proteins, Chromosome Segregation, Mitosis, Female, Male, Spindle Apparatus, Mice, Inbred BALB C, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some species, to their microtubule depolymerization activity. Plasmodium spp. exhibit an atypical endomitotic cell division in which chromosome condensation and spindle dynamics in the different proliferative stages are not well understood. Genome-wide shared orthology analysis of Plasmodium spp. revealed the presence of two kinesin-8 motor proteins, kinesin-8X and kinesin-8B. Here we studied the biochemical properties of kinesin-8X and its role in parasite proliferation. In vitro, kinesin-8X has motility and depolymerization activities like other kinesin-8 motors. To understand the role of Plasmodium kinesin-8X in cell division, we used fluorescence-tagging and live cell imaging to define its location, and gene targeting to analyse its function, during all proliferative stages of the rodent malaria parasite P. berghei life cycle. The results revealed a spatio-temporal involvement of kinesin-8X in spindle dynamics and an association with both mitotic and meiotic spindles and the putative microtubule organising centre (MTOC). Deletion of the kinesin-8X gene revealed a defect in oocyst development, confirmed by ultrastructural studies, suggesting that this protein is required for oocyst development and sporogony. Transcriptome analysis of Δkinesin-8X gametocytes revealed modulated expression of genes involved mainly in microtubule-based processes, chromosome organisation and the regulation of gene expression, supporting a role for kinesin-8X in cell division. Kinesin-8X is thus required for parasite proliferation within the mosquito and for transmission to the vertebrate host.

Published
2019

5. Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver

Author

Franke-Fayard, Blandine, Marin-Mogollon, Catherin, Geurten, Fiona J. A., Chevalley-Maurel, Séverine, Ramesar, Jai, Kroeze, Hans, Baalbergen, Els, Wessels, Els, Baron, Ludivine, Soulard, Valérie, Martinson, Thomas, Aleshnick, Maya, Huijs, Antonius T. G., Subudhi, Amit K., Miyazaki, Yukiko, Othman, Ahmad Syibli, Kolli, Surendra Kumar, Lamers, Olivia A. C., Roques, Magali, Stanway, Rebecca R., Murphy, Sean C., Foquet, Lander, Moita, Diana, Mendes, António M., Prudêncio, Miguel, Dechering, Koen J., Heussler, Volker T., Pain, Arnab, Wilder, Brandon K., Roestenberg, Meta, and Janse, Chris J.

Published
2022
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6. PlasmodiumNEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

Author

Zeeshan, Mohammad, primary, Rashpa, Ravish, additional, Ferguson, David J., additional, Mckeown, George, additional, Nugmanova, Raushan, additional, Subudhi, Amit K., additional, Beyeler, Raphael, additional, Pashley, Sarah L., additional, Markus, Robert, additional, Brady, Declan, additional, Roques, Magali, additional, Bottrill, Andrew R., additional, Fry, Andrew M., additional, Pain, Arnab, additional, Vaughan, Sue, additional, Holder, Anthony A., additional, Tromer, Eelco C., additional, Brochet, Mathieu, additional, and Tewari, Rita, additional

Published
2024
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8. Ockham on Habits

Author

Roques, Magali, Klima, Gyula, Editor-in-Chief, Faucher, Nicolas, editor, and Roques, Magali, editor

Published
2018
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9. RETRACTED CHAPTER: Contingency and Causal Determinism from Scotus to Buridan

Author

Roques, Magali, Bokulich, Alisa, Series Editor, Renn, Jürgen, Series Editor, Massimi, Michela, Series Editor, Divarci, Lindy, Managing Editor, Arabatzis, Theodore, Editorial Board Member, Douglas, Heather E., Editorial Board Member, Gayon, Jean, Editorial Board Member, Glick, Thomas F., Editorial Board Member, Goenner, Hubert, Editorial Board Member, Heilbron, John, Editorial Board Member, Kormos-Buchwald, Diana, Editorial Board Member, Lehner, Christoph, Editorial Board Member, McLaughlin, Peter, Editorial Board Member, Nieto-Galan, Agustí, Editorial Board Member, Ordine, Nuccio, Editorial Board Member, Schweber, Sylvan S., Editorial Board Member, Simões, Ana, Editorial Board Member, Stachel, John J., Editorial Board Member, Zhang, Baichun, Editorial Board Member, Omodeo, Pietro Daniel, editor, and Garau, Rodolfo, editor

Published
2019
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11. Ockham’s Semantics of Real Definitions

Author

Roques, Magali, Klima, Gyula, Editor-in-Chief, Wilcox, Russell, Series Editor, Lagerlund, Hendrik, Series Editor, Jacobs, Jonathan, Series Editor, Bonevac, Dan, Advisory Editor, Borden, Sarah, Advisory Editor, Feser, Edward, Advisory Editor, Garcia, Jorge, Advisory Editor, Jaworski, WIlliam, Advisory Editor, Davis, Joseph E., Advisory Editor, Meier-Oeser, Stephan, Advisory Editor, Ignacio Murillo, Jose, Advisory Editor, Normore, Calvin, Advisory Editor, Rush, Penelope, Advisory Editor, Zupko, Jack, Advisory Editor, Pelletier, Jenny, editor, and Roques, Magali, editor

Published
2017
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12. Retraction Note to: An Introduction to Mental Language in Late Medieval Philosophy

Author

Roques, Magali, Pelletier, Jenny, Klima, Gyula, Editor-in-Chief, Wilcox, Russell, Series Editor, Lagerlund, Hendrik, Series Editor, Jacobs, Jonathan, Series Editor, Bonevac, Dan, Advisory Editor, Borden, Sarah, Advisory Editor, Feser, Edward, Advisory Editor, Garcia, Jorge, Advisory Editor, Jaworski, WIlliam, Advisory Editor, Davis, Joseph E., Advisory Editor, Meier-Oeser, Stephan, Advisory Editor, Ignacio Murillo, Jose, Advisory Editor, Normore, Calvin, Advisory Editor, Rush, Penelope, Advisory Editor, Zupko, Jack, Advisory Editor, Pelletier, Jenny, editor, and Roques, Magali, editor

Published
2017
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13. An Interview with Claude Panaccio

Author

Pelletier, Jenny, Roques, Magali, Klima, Gyula, Editor-in-Chief, Wilcox, Russell, Series Editor, Lagerlund, Hendrik, Series Editor, Jacobs, Jonathan, Series Editor, Bonevac, Dan, Advisory Editor, Borden, Sarah, Advisory Editor, Feser, Edward, Advisory Editor, Garcia, Jorge, Advisory Editor, Jaworski, WIlliam, Advisory Editor, Davis, Joseph E., Advisory Editor, Meier-Oeser, Stephan, Advisory Editor, Ignacio Murillo, Jose, Advisory Editor, Normore, Calvin, Advisory Editor, Rush, Penelope, Advisory Editor, Zupko, Jack, Advisory Editor, Pelletier, Jenny, editor, and Roques, Magali, editor

Published
2017
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14. RETRACTED CHAPTER: An Introduction to Mental Language in Late Medieval Philosophy

Author

Roques, Magali, Pelletier, Jenny, Klima, Gyula, Editor-in-Chief, Wilcox, Russell, Series Editor, Lagerlund, Hendrik, Series Editor, Jacobs, Jonathan, Series Editor, Bonevac, Dan, Advisory Editor, Borden, Sarah, Advisory Editor, Feser, Edward, Advisory Editor, Garcia, Jorge, Advisory Editor, Jaworski, WIlliam, Advisory Editor, Davis, Joseph E., Advisory Editor, Meier-Oeser, Stephan, Advisory Editor, Ignacio Murillo, Jose, Advisory Editor, Normore, Calvin, Advisory Editor, Rush, Penelope, Advisory Editor, Zupko, Jack, Advisory Editor, Pelletier, Jenny, editor, and Roques, Magali, editor

Published
2017
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17. Putative prefoldin complex subunit 5 of Plasmodium berghei is crucial for microtubule formation and parasite development in the mosquito.

Author

Beyeler, Raphael, Jordan, Melanie, Dorner, Lilian, He, Buyuan, Cyrklaff, Marek, Roques, Magali, Stanway, Rebecca, Frischknecht, Friedrich, and Heussler, Volker

Subjects
PLASMODIUM, OOCYSTS, PLASMODIUM berghei, MOSQUITOES, PARASITE life cycles, MICROTUBULES, SPOROZOITES
Abstract

Plasmodium sporozoite development in and egress from oocysts in the Anopheles mosquito remains largely enigmatic. In a previously performed high‐throughput knockout screen, the putative subunit 5 of the prefoldin complex (PbPCS5, PBANKA_0920100) was identified as essential for parasite development during mosquito and liver stage development. Here we generated and analyzed a PbPCS5 knockout parasite line during its development in the mosquito. Interestingly, PbPCS5 deletion does not significantly affect oocyst formation but leads to a growth defect resulting in aberrantly shaped sporozoites. Sporozoites produced in the absence of PbPCS5 were thinner, markedly elongated, and did, in most cases, not contain a nucleus. Sporozoites contained fewer subpellicular microtubules, which reached deep into the sporoblast during sporogony where they contacted and indented nuclei. These aberrantly shaped sporozoites did not reach the salivary glands, and we, therefore, conclude that PbPCS5 is essential for sporogony and the life cycle progression of the parasite during its mosquito stage. [ABSTRACT FROM AUTHOR]

Published
2024
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24. [Quaestio 3]

Author

Duns Scot, Jean, primary, Boulnois, Olivier, additional, Demange, Dominique, additional, Lévi, Ide, additional, Trégo, Kristell, additional, and Roques, Magali, additional

Published
2020
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26. [Quaestio 4]

Author

Duns Scot, Jean, primary, Boulnois, Olivier, additional, Demange, Dominique, additional, Lévi, Ide, additional, Trégo, Kristell, additional, and Roques, Magali, additional

Published
2020
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30. [Quaestio 2]

Author

Duns Scot, Jean, primary, Boulnois, Olivier, additional, Demange, Dominique, additional, Lévi, Ide, additional, Trégo, Kristell, additional, and Roques, Magali, additional

Published
2020
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36. [Quaestio 1]

Author

Duns Scot, Jean, primary, Boulnois, Olivier, additional, Demange, Dominique, additional, Lévi, Ide, additional, Trégo, Kristell, additional, and Roques, Magali, additional

Published
2020
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46. Retraction Note to: Contingency and Causal Determinism from Scotus to Buridan

Author

Roques, Magali, Bokulich, Alisa, Series Editor, Renn, Jürgen, Series Editor, Massimi, Michela, Series Editor, Divarci, Lindy, Managing Editor, Arabatzis, Theodore, Editorial Board Member, Douglas, Heather E., Editorial Board Member, Gayon, Jean, Editorial Board Member, Glick, Thomas F., Editorial Board Member, Goenner, Hubert, Editorial Board Member, Heilbron, John, Editorial Board Member, Kormos-Buchwald, Diana, Editorial Board Member, Lehner, Christoph, Editorial Board Member, McLaughlin, Peter, Editorial Board Member, Nieto-Galan, Agustí, Editorial Board Member, Ordine, Nuccio, Editorial Board Member, Schweber, Sylvan S., Editorial Board Member, Simões, Ana, Editorial Board Member, Stachel, John J., Editorial Board Member, Zhang, Baichun, Editorial Board Member, Omodeo, Pietro Daniel, editor, and Garau, Rodolfo, editor

Published
2019
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