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2. Risk of Bowel Obstruction in Patients Undergoing Neoadjuvant Chemotherapy for High-risk Colon Cancer: A Nested Case-control Matched Analysis of an International, Multi-centre, Randomised Controlled Trial (FOxTROT)

Author

Glasbey, James, Glasbey, James, Beggs, Andrew, Glimelius, Bengt, Gray, Richard, Handley, Kelly, Laurberg, Søren, Magill, Laura, Murakami, Keigo, Palmer, Andy, Quirke, Philip, Seligman, Jenny, Seymour, Matt, Sinha, Yash, West, Nick, Morton, Dion, Glasbey, James, Handley, Kelly, Palmer, Andy, Morton, Dion, Crosby, T., Olliff, J., Peto (Chair), R., Brown, Gina, Ferry, David, Glimelius, Bengt, Gray, Richard, Handley, Kelly, Ismail, Tariq, Laurberg, Søren, Magill, Laura, Morton, Dion, Oliver, Alf, Quirke, Phil, Seymour, Matt, Scott, Nigel, Seligman, Jenny, Swift, Ian, Warren, Bryan, West, Nick, Northover, J., Parmar (Chair), M., Slevin, M., Magill, Laura, Gray, Richard, Handley, Kelly, Wilcockson, Adrian, Gray, Zoe, Lancaster, Dominic, Brown, James, Palmer, Andrew, Adie, Ladan, Kennedy, Georgia, Eld, M., Holt, G., Yilmaz, M., Spendler, K. Garm, Hansen, F., Laurberg, S., Rosenkilde, M., Ahlstrom, H., Glimelius, B., Abgamu, D., Day, N., Walsh, C., Bannister, J., Furniss, D., Morgan, S., Walkington, L., Yates, S., Branagan, G., Mustajab, A., O’Neil, H., Rees, C., Geh, I., Hendrickse, C., Langman, G., Pallan, A., Conn, A., Lowe, A., Ostrowski, J., Steward, M., Callaway, M., Falk, S., Thomas, M., Wong, N., Cast, J., Hartley, J., Roy, R., Tiam, R., Blunt, D., Cleator, S., Dawson, P., Goldin, R., Gujral, D., Lowdell, C., Ziprin, P., Clenton, S., Dewdney, A., Euinton, H., Furniss, D., Gupta, R., Tarapowewalla, D., Wilshaw, V., Braun, M., Chakrabarty, B., Hill, J., Laasch, H., Saunders, M., Cruickshank, N., Davies, M., Muzaffar, S., Orme, A., Punia, P., Rea, D., Campbell, F., Hughes, M., Palmer, D., Rooney, P., Abbott, G., Hamid, B., Vimalachandran, D., Berry, J., Hinson, F., Maarouf, Z., Nicoll, J., Adams, C., Denson, J., Jackson, S., Sherriff, D., Kweka, E., McAdam, G., Peters, M., Roy, R., Khaira, M., Kurien, G., Robinson, J., Wadsley, J., White, D., Young, R., Dega, R., Lamparelli, M., Orbell, J., Osborne, R., Taylor, P., Thomas, T., Gopalakrishnan, K., Jadhav, V., Scott-Brown, M., Baijal, S., Chapman, M., Glaholm, J., Nelson, C., Singh, R., Harrison, J., Last, K., Scott, D., Scullion, D., Lind, P., Milosavljevic, Z., Dent, J., Ilsley, D., Littleford, S., Roberts, C., Crabtree, M., Orrell, J., Sherwin, E., Smith, S., Soomal, R., Braun, M., De, A., Khan, A., Khan, U., Lavin, V., McBain, C., Radharkrishna, G., Sil, R., Weerasinghe, S., Hill, J., Lee, S., Wright, P., Church, R., Holland, C., Kunene, V., Thompson, A., Glynne-Jones, R., Goh, V., Livingstone, J., Richman, P., Barlow, C., Burn, P., Geraghty, J., Walther, J., Grumett, S., Mangalika, S., Qaiyum, M., Williams, G., Borgstein, R., Bridgewater, J., Melville, D., Rees, J., Coxon, F., Hainsworth, P., Needham, S., Scott, J., Asmussen, J., Hansen, T., Jensen, K., Pfeiffer, P., Alkhaldi, A., Brittenden, J., Jackson, A., Kamposioras, K., Kumaran, G., Macklin, C., Alexander, J., Harle, A., Hickish, T., Talbot, R., Tarver, D., Bridgewater, J., Partridge, W., Sundaresan, V., Vivekanandan, S., Agrawal, N., Higginson, A., Muthuramalingam, S., O’Leary, D., Devarajan, G., Gulati, M., Kerwat, R., Maisey, N., Mikhaeel, G., Ismail, T., Middleton, G., Page, A., Steven, N., Taniere, P., Gutmann, J., Huang, J., Raouf, S., Dunn, W., Escola, C. Lopez, Potter, V., Scholefield, J., Walker, G., Zaitoun, A., Eason, D., McPhail, N., Mmeka, W., Stenhouse, G., Watson, A., Fozard, B., Hickish, T., Snape, S., Ellis, R., Faux, W., Jenkins, R., Maskell, G., Kulkarni, R., Lund, J., Menon, S., Singh, R., Chandler, I., Daniels, I., Harries, S., Osborne, M., Bell, J., Krell, D., Mayer, A., Ogunbiyi, O., Watkins, J., Bronder, C., Eaton, D., Taylor, A., Brown, G., Cunningham, D., Tekkis, P., Wotherspoon, A., Dobson, M., Mitchell, P., Pitt, M., Scott, N., Susnerwala, S., Adab, F., Britton, I., Ghiridaran, S., Howitt, C., Kirby, R., Biddlestone, L., Dalton, S., De Winton, E., Phillips, A., Ferry, D., Grumett, S., Kawesha, A., Maleki, K., Momtahan, N., Burnett, H., Hayes, S., Soop, M., Branagan, G., Cook, I., Cook, S., Iveson, T., Shablak, A., Coup, A., Hamid, A., Moore, P., O’Toole, L., Pai, D., Bateman, A., Bateman, A., Blaquiere, R., Nichols, P., Chappell, M., Dworkin, M., Jain, S., Tsang, D., Hopkins, K., Loveday, E., Lyons, A., Rooney, N., Ali, N., Chatterjee, M., Chiphang, A., Dundas, S., Myint, A. Sun, Zeiderman, M., Beharry, N., Chong, H., Lofts, F., Melville, D., Finan, P., Seymour, M., Tolan, D., West, N., Anyamene, N., Burling, D., Kennedy, R., Moorghen, M., Agrawal, S., Hasan, J., Mehta, S., Saeed, M., Burgess, P., John, L., Lowndes, S., Planner, A., Campbell, F., Hughes, M., Rooney, P., Smith, D., Hochhauser, D., Obichere, A., Rodriguez-Justo, M., Shiu, K., Taylor, S., Correa, P., James, S., Shatwell, W., Williams, N., Brady, J., Lanaspre, E., Mikhaeel, G., Ahmad, M., Gill, T., Wilson, D., Adams, R., Beehen, R., Morgan, M., Lindh, B., Adams, R., Morgan, M., Ford, A., Gopal, K., Pranesh, N., Shareef, D., Tighe, M., Busby, K., Correa, P., Sanders, S., Sinha, R., Ahmad, R., Desai, S., Ramesh, S., Hilman, S., Lott, M., O’Brien, J., Radstone, D., West, D., Amin, S., Hampton, J., Hornbuckle, J., Kitsanta, P., Ali, M., Desai, A., Hadaki, M., Hall, M., Arul, D., Hochhauser, D., Leonard, P., Mukhtar, H., Murray, D., Baxter, A., Churn, M., Farrugia, D., Lake, S., Smith, G., Bansal, A., Chandran, P., Corr, C., Gollins, S., Davenport, A., Saunders, M., Sukumar, S., Bathurst, N., Beaumont, E., Cooper, E., Francis, N., Sephton, M., Sparrow, G., Clarke, A., Haselden, J., Last, K., Woodcock, N., Atkinson, M., Gollins, S., Gupta, M., Maw, A., Abdullah, N., Bale, C., and Lord, M.

Published
2023
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7. Topology and Intelligent Data Analysis

Author

Robins, V., Abernethy, J., Rooney, N., Bradley, E., Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, R. Berthold, Michael, editor, Lenz, Hans-Joachim, editor, Bradley, Elizabeth, editor, Kruse, Rudolf, editor, and Borgelt, Christian, editor

Published
2003
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18. Irish cardiac society: Proceedings of annual general meeting held 20th & 21st November 1992 in Dublin Castle

Author

Cullen, C., MacKenzie, G., Adgey, J., Lavin, F., Keane, M., Forde, A., Shah, P., Gannon, F., Daly, K., McClements, B. M., McNeil, A. J., Wilson, C. M., Webb, S. W., Campbell, N. P. S., Khan, M. M., O’Murchu, B., Gersh, B. J., Bailey, K. R., Holmes, D. R., Foley, D. P., Hermans, W. R., Rensing, B. J., Vos, J., Herman, J-P, Serruys, P. W., Mannion, A., Finn, J., Grimes, H., Lonergan, M., O’Donnell, Daly, L., McGovern, E., Graham, I., Joseph, P. A., Robinson, K., Kinsella, T., Crean, P., Gearty, G., Walsh, M., Ryan, M., Clarke, R., Refsum, R., Ueland, P., Coehrane, D. J., Stewart, A. J., McEneaney, D. J., Allen, J. D., Anderson, J., Dempsey, G., Adgey, A. A. J., Casey, F. A., Mulholland, H. C., Craig, B. G., Power, R., Rooney, N., O’Keeffe, D. B., McComb, J., Wilson, C., Tan, K. S., Pye, C., McCabe, N., Hickey, N., McEneaney, D., Cochrane, D., Oslizlok, P. C., Case, C. L., Gillette, P. C., Knick, Barbara J., Henry, L. P. N., Blair, L., Gumbrielle, T., Bourke, J. P., Hilton, C. J., Campbell, R. W. F., Kearney, P. P., Fennell, F., McKiernan, S., Fennell, W., Escaned, J., Hermans, W. R, Umans, V. A., de Jaegere, P. P., de Feyter, P. J., Galvin, J., Leavey, S., Sugrue, D., Vallely, S. R., Campbell, N. P. S., Laird, J. D., Ferguson, R., Duff, S., Bridges, A. B., Pringle, T. H., McNeill, G. P., McLaren, M., Belch, J. J. F., O’Sullivan, L., Bain, H., Hunter, S., Wren, C., Hennesy, A., Codd, M., Daly, C., McCarthy, C., Carroll, K., Coakley, F., O’Mahony, S., Sullivan, P. A., Kearney, P., Higgins, T., Crowey, J. J, Donnelly, S. M., Tobin, M., FitzGerald, O., Bresnihan, B., Maurer, B. J., Quigley, P. J., Shelley, E., Collins, C., Hickey, N., ulcahy, R., Johnston, P. W., Gibson, J., Crowe, P., King, G., Freyne, P. J., Geary, G., McAdam, B., Sheahan, R., Gaylani, N. El, Simpson, A., Temperley, I., Mulcahy, F., McGee, H. M., Graham, T., Crowe, B., Horgan, J. H., McGinley, J., Hurley, J., Neligan, M., Austin, C., Cleland, J., Gladstone, D., O’Kane, H., O’Sullivan, J., Hasan, A., Hamilton, J. R. L., Hunter, S., Dark, J. H., McDaid, C. M., Phillips, A. S., Lewis, S. A., McMurray, T. J., Walsh, K. P., Abrams, S. E., Diamond, M., Clarkson, M. J., Rutsch, W., Emanuelsson, H., Danchin, N., Wijns, W., and Chappuis, F.

Published
1993
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19. A survey exploring the impact of housing and husbandry on pet snake welfare.

Author

Cargill, B. M., Benato, L., and Rooney, N. J.

Subjects
ANIMAL welfare, HOUSING, STRETCH (Physiology), SNAKES, SYMPTOMS, COLUBRIDAE
Abstract

Snake ownership is popular; however, housing and care may not always satisfy the animal's welfare needs. For example, snakes are often kept in environmental conditions that restrict their ability to stretch out fully or move around, using rectilinear locomotion. To date, little empirical data exist on the housing and husbandry of captive snakes and how these impact welfare. This study analyses survey responses from 744 snake owners worldwide and explores potential welfare concerns for snakes kept within private homes. It documents the most common housing and husbandry methods and compares the three most common families (Pythonids, Boids and Colubrids). Owner-reported data were used to derive scores for two potential welfare indicators: number of clinical signs of ill health and the number of reported negative (abnormal) behaviours. Using these indicators, associations were tested with snake-keeping variables, such as enclosure size, level of enrichment temperature and humidity. Owners reported that 90.7% (n = 675) of snakes adopted rectilinear (straight-line or near straight-line) positions or movements. Snakes kept in enclosures > I snake length tended to have more enrichment types and were reported with fewer clinical signs of ill health. Some snakes were housed at unknown temperature (7.7%) or humidity (48.1%) ranges or in environmental conditions not in keeping with current recommended guidelines. Corn snakes (Pantherophis guttatus) were the most likely species to be kept at a humidity which did not match recommendations which may present a welfare concern.This study's results can be used to target husbandry guidance for future recommendations and care manuals. [ABSTRACT FROM AUTHOR]

Published
2022
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21. S8A-01 SESSION 8A

Author

Culshaw, L., primary, Kearney, A., additional, Piggott, K., additional, Thornhill, H., additional, Care, H., additional, Dalton, L., additional, Dunaway, D., additional, Evans, M., additional, Horton, J., additional, Johnson, D., additional, Kennedy-Williams, P., additional, Middleton-Curran, L., additional, O’Leary, G., additional, Parks, C., additional, Rooney, N., additional, and Wright, G., additional

Published
2019
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22. S8A-02 SESSION 8A

Author

Care, H. J., primary, Dalton, L., additional, Culshaw, L., additional, Horton, J., additional, Kearney, A., additional, Kennedy-Williams, P., additional, O’Leary, G., additional, Piggott, K., additional, Rooney, N., additional, and Wright, G., additional

Published
2019
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23. The effect of blindfolding and swaddling on the stress response to handling in domestic rabbits.

Author

McIndoe, K. S., Saunders, R., Blackwell, E. J., and Rooney, N. J.

Subjects
RABBITS, ANIMAL welfare, EUROPEAN rabbit, WILDLIFE rescue, HEART beat, PHYSIOLOGICAL stress
Abstract

Stress during handling can negatively impact the welfare of an animal. Gradual habituation or systematic desensitisation can reduce this but is not always possible. Blindfolding has been shown to decrease stress indicators, including heart rate and struggling in cattle (Bos taurus), but has not been studied in domestic rabbits (Oryctolagus cuniculus). We surveyed 49 wildlife rescues, rehabilitators and veterinarians, and found that blindfolding and swaddling are widely used and believed to reduce stress and struggling in rabbits. However, these methods may simply preclude escape and result in sensitisation over repeated exposure. We next conducted a controlled trial investigating the effects of blindfolding and swaddling repeatedly over five days on behavioural and physiological indicators of stress in 40 domestic rabbits. Neither blindfolding nor swaddling had significant impacts on heart or respiratory rate, compared to a partial hood control treatment, which involved similar levels of manipulation, but without visual or movement restriction. Behavioural responses showed variable trends, eg rabbits were more likely to approach food after handling with swaddling. Baseline levels varied significantly between individuals, suggesting previous experience to be an important determinant. Heart rates were universally high, showing that individuals in this study were stressed by handling to such an extent, that overall, effects of both blindfolding and swaddling on physiological indicators of stress were minimal. We suggest that blindfolding and swaddling may be useful as means of limiting the procedure duration and risk of injury by reducing struggling, but this study provides no evidence that welfare is otherwise improved. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Air weapon fatalities

Author

Milroy, C M, Clark, J C, Carter, N, Rutty, G, and Rooney, N

Published
1998

29. Massive Bladder Haemorrhage

Author

Murray, J. A., Rooney, N., Preston, F. E., McIvor, James, Williams, Grant, and Ezzibdeh, M. Y.

Published
1986

31. Coeliac disease and malignancy of the duodenum: diagnosis by endoscopy, successful treatment of the malignancy, and response to a gluten free diet

Author

Hall, M.J., Cooper, B.T., Rooney, N., Thompson, H., and Read, A.E.

Subjects
Gastrointestinal cancer -- Causes of, Celiac disease -- Complications, Health
Abstract

Celiac disease is a gastrointestinal disorder characterized by malabsorption, malnutrition, diarrhea, intestinal bleeding, and decreased blood levels of calcium. Patients with celiac disease are inordinately sensitive to dietary gluten products, and often respond favorably to a gluten-free diet. Persons with celiac disease have a higher incidence of lymphoma (cancer of the lymphatic system) than the general population. In celiac disease patients, the cancer usually afflicts the gastrointestinal system and is widely disseminated at the time of diagnosis, resulting in a poor prognosis for these patients. A case is reported of a 64-year-old man who sought medical treatment for steatorrhea (excessive fat in the stools). He had a five-year history of abdominal pain and fatty stools. Endoscopy (a diagnostic technique for viewing the interior of the gastrointestinal tract by introducing a flexible fiber-optic viewing device) did not reveal any abnormalities, nor did computed tomographic imaging (CT scan) of the abdomen. Radiological viewing of the intestinal tract with barium indicated the presence of a tumor; this was surgically removed and was found to be malignant. Chemotherapy followed the surgery, and the patient was maintained on a gluten-free diet. The patient remained alive and well for 28 months following surgery, until he died of an unrelated cause (fractured skull). This case represents one of the earliest diagnoses of celiac disease-related malignant tumors, and its successful treatment. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

35. Feedback effects between the food chain and induced defense strategies

Author

DeAngelis, D.L., Vos, M., Mooij, W.M., Abrams, P.A., Rooney, N., McCann, K., Noakes, D., Ecosysteem Studies, and Voedselweb Onderzoek

Subjects
Adaptive traits, Food chain, Ideal free distribution, Evolutionary biology, Feedback effect, Evolutionarily stable state, Biology, Trophic level, Adaptive evolution, Evolutionarily stable strategy
Abstract

11.1 Abstract 214 11.2 Introduction 214 11.3 Methods 217 11.3.1 Adaptive evolution of the induction and decay functions 219 11.3.2 Individual-based version of the model 220 11.4 Results 223 11.4.1 Does the evolutionarily stable state correspond to an Ideal Free Distribution?....... 226 11.4.2 Implications of g1 as an adaptive trait 228 11.5 Discussion 231 11.6 Acknowledgments 233 11.7 Literature Cited 233

Published
2007

41. Overexpression of p53 in Hodgkin's disease: lack of correlation with Epstein-Barr virus infection

Author

D. C. Rowlands, Ann Williams, Gerald Niedobitek, Hermann Herbst, Rooney N, Lawrence S. Young, E. L. Jones, Hall P, and Padfield J

Subjects
Herpesvirus 4, Human, Population, Gene Expression, Gene mutation, medicine.disease_cause, Herpesviridae, Virus, Pathology and Forensic Medicine, hemic and lymphatic diseases, medicine, Gammaherpesvirinae, Humans, education, Epstein–Barr virus infection, In Situ Hybridization, education.field_of_study, biology, medicine.disease, biology.organism_classification, Genes, p53, Epstein–Barr virus, Hodgkin Disease, Immunohistochemistry, Lymphoma, Tumor Virus Infections, Cancer research
Abstract

Recent work has shown that p53 gene mutations are frequently found in Epstein-Barr virus (EBV)-positive and EBV-negative cases of Burkitt's lymphoma but not in EBV-associated undifferentiated nasopharyngeal carcinomas (NPCs). Similar viral gene expression patterns are observed in undifferentiated NPCs and in EBV-positive cases of Hodgkin's disease (HD), suggesting that the contribution of the virus to the pathogenesis of these malignancies may also be similar. We have analysed 116 cases of HD for EBV association and for immunohistologically detectable overexpression of p53. p53 overexpression was detected in the tumour cell population of 37 (32 per cent) of the cases. Fifteen cases showed p53-specific labelling of more than 40 per cent of tumour cells; in six of these, virtually all tumour cells were stained. In eight cases, between 5 and 40 per cent of tumour cells were labelled, and in another 14 cases, less than 5 per cent of tumour cells expressed detectable amounts of p53. EBV-positive HD cases were found in all groups with different levels of p53 overexpression as well as amongst p53-negative cases. While a more detailed analysis of the p53 gene in HD is required, these data show that overexpression of p53 in HD is heterogeneous and that there is no simple correlation between EBV infection and p53 overexpression.

Published
1993

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