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The central granular cell odontogenic tumor (CGCOT) is a rare, benign, slowly growing, odontogenic neoplasm. CGCOT was not considered as a distinct entity in the WHO classification reported on 2017. This study reports a rare case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white woman. In addition, to better delineate the clinical, radiographic, histopathologic and immunohistochemical characteristics of CGCOT, a literature review of all published cases (in PubMed/ Google Scholar/ MEDLINE/Scopus) of CGCOT is provided. CGCOT is a very uncommon tumor, with only 51 reported cases in the literature. The present case is interesting regarding to its rarity for being in the maxillary anterior region, which has not been previously reported in Asia. The immunohistochemical findings of the current case and other cases in the literature review, verified the mesenchymal origin of granular cells and odontogenic nature of the epithelium islands, which can be a possible promise for placing this lesion in the future WHO odontogenic tumor classification.

Arteriovenous malformation of head and neck is a rare vascular anomaly but when present, it is persistent and progressive in nature. It can also represent a lethal benign disease due to massive hemorrhage. There are several indications for treatment including age, location, extension and type of vascular malformation. Endovascular therapy can effectively cure most lesions with limited tissue involvement. Surgery can be used in selected cases in combination with embolization. Here, we present a rare case of arteriovenous malformation of mandible with floating tooth appearance in an 11-year-old boy patient. Given the spectrum of imaging presentations seen and the crossover with other lesions, microscopic histopathological examination is the gold standard for diagnosis.

Background: The majority of oral cancers, which make up 25% to 30% of all malignancies in the oral area, are lip cancers (LCs). As far as we are aware, there haven’t been any thorough epidemiologic research on LC. This study’s objective is to look at the trend of tumor prevalence across the whole lip area in Iranians between 2004 and 2016 (Tehran, Iran).Methods: This retrospective cross-sectional study, which examined tumor location, age, gender distribution, histological tumor type, metastasis, clinical diagnosis, and recurrence of the lesion, was carried out on the pathology records of patients admitted to the Department of Pathology at the Cancer Institutes of Imam Khomeini hospital and Tajrish hospital between 2004 and 2016. The data was analyzed using the chi-square test and Fisher’s exact test.Results: Out of a total of 237392 biopsy reports filed with the Department of Pathology, 512 instances (0.21%, 92% malignant, and 8% premalignant) involving 385 (75.2%) males and 127 (24.8%) females were discovered to be lip-related. A statistically significant difference between sex and the site of the lesion was found using the chi-square test (P = 0.032). Lower lip and squamous cell carcinomas (SCC) were the most typical locations and types, respectively. Recurrence and metastasis were noted in 7.8% and 25.84% of cases, respectively, with males more likely than women to experience these outcomes. Moreover, there was a significant (P = 0.025) correlation between gender and histological tumor type.Conclusion: The chance of developing LC was greater in men over the age of 54. The most typical location for SCC involvement is the lower lip. We discovered that women had an increased frequency of upper lip lesions. These disparities might be the result of gender-specific professional and behavioral differences. Hence, as possible contributors to the occurrence of LCs, variables including occupational and behavioral variations and public knowledge of sun exposure should be carefully evaluated.

Adenomatoid odontogenic tumor (AOT) is a benign slow-growing, asymptomatic epithelial odontogenic neoplasm. This lesion has been known for its varied clinical and histoarchitectural patterns. Most AOTs occur intra-osseously in the anterior maxilla associated with the unerupted tooth. Clinically, AOT is sometimes misdiagnosed as an odontogenic cyst. Although enucleation and curettage for AOT is the most common treatment modality, accurate histopathological diagnosis is essential to avoid unnecessary extensive surgery. Here, we present a rare challenging case of an extrafollicular cystic adenomatoid odontogenic tumor occurring in the body of the mandible in a 23-year-old female patient, which was diagnosed clinically and radiographically as glandular odontogenic cyst. The diagnosis of adenomatoid odontogenic tumor was confirmed through histopathological examination.