Search

Karumathil M Murali,1,2 Judy Mullan,2 Steven Roodenrys,3 Hicham I Cheikh Hassan,1,2 Maureen A Lonergan1 1Department of Nephrology, Wollongong Hospital, Wollongong, NSW, Australia; 2School of Medicine, University of Wollongong, Wollongong, NSW, Australia; 3School of Psychology, University of Wollongong, Wollongong, NSW, AustraliaCorrespondence: Karumathil M Murali, Department of Nephrology, Wollongong Hospital, Wollongong, NSW, 2500, Australia, Tel +61 2 42952800, Fax +61 2 4295 2916, Email karumathil.murali@health.nsw.gov.auAim: To assess the quantitative and categorical agreement between two methods of measuring medication adherence: pharmacy refill-based medication possession rates and self-reported medication adherence scale.Background: Categorisation of adherence metrics using empirical cut-off scores can lead to misclassification, which can be overcome by expressing adherence as a continuous variable. Pharmacy refill-based adherence can be reported as actual rates, but the validity of expressing self-reported medication adherence scores as a continuous variable to reflect adherence is unknown and its quantitative agreement with refill-based adherence rates untested.Methods: Patients with kidney disease, including dialysis patients, from Illawarra Shoalhaven region of New South Wales, Australia were recruited between January 2015 and June 2016 to this cross-sectional study. Medication adherence was assessed using the self-reported Morisky Medication Adherence Scale (MMAS) and two pharmacy refill-based measures, Medication Possession Ratio (MPR) and Proportion of Days Covered (PDC) for antihypertensives and cardiometabolic drugs. Categorical and quantitative agreement between self-reported adherence and pharmacy refill-based adherence were assessed using tests of trend, analysis of covariance (ANCOVA), Cohen’s kappa and Bland-Altman analysis.Results: We recruited 113 patients. There was a significant declining trend of MPR (p < 0.001) and PDC (< 0.001 for antihypertensives, p = 0.004 for cardiometabolic) scores among categories with worsening MMAS adherence. Adjusted ANCOVA showed significant association between self-report and pharmacy refill-based adherence (p < 0.001). Weighted Cohen’s kappa statistics showed fair agreement between the self-report and pharmacy refill-based categories. Bland-Altman’s analysis showed less than 5% of cases were outside the limits of agreement (− 0.36 to 0.27) and the bias for MMAS was negative (− 0.05 to − 0.09), indicating MMAS did not overestimate adherence.Conclusion: There is modest agreement between pharmacy refill-based measures and self-report MMAS measures when assessed categorically or quantitatively. Assessing adherence as a continuous variable should be considered to overcome the challenges associated with categorization of adherence based on arbitrary thresholds.Keywords: medication adherence, patient compliance, self report, medication possession rate, proportion of days covered, kidney failure, chronic kidney disease

There is a growing body of literature that suggests that long-term memory (LTM) and short-term memory (STM) structures that were once thought to be distinct are actually co-dependent, and that LTM can aid retrieval from STM. The mechanism behind this effect is commonly argued to act on item memory but not on order memory. The aim of the current study was to examine whether LTM could exert an influence on STM for order by examining an effect attributed to LTM, the phonological neighbourhood effect, in a task that reduced the requirement to retain item information. In Experiment 1, 18 participants completed a serial reconstruction task where neighbourhood density alternated within the lists. In Experiment 2, 22 participants completed a serial reconstruction task using pure lists of dense and sparse neighbourhood words. In Experiment 3, 22 participants completed a reconstruction task with both mixed and pure lists. There was a significant effect of neighbourhood density with better recall for dense than sparse neighbourhood words in pure lists but not in mixed lists. Results suggest that LTM exerts an influence prior to that proposed by many models of memory for order. [ABSTRACT FROM AUTHOR]

The relationship between performance in final high school studies, on which the university entrance system is based, and performance in a psychology major at university is examined. A total of 241 students were identified who completed first year psychology at a regional university, and had started university within two years of completing high school. Their marks in psychology subjects over the 3-year major program, their University Admission Index (UAI) and Higher School Certificate subject profile were extracted from the university student records system and subjected to a series of analyses. Psychology marks were averaged to produce a score for each of the three year-levels. UAI correlated with performance at all three levels (.42 - .49) and was the strongest predictor of performance. Having studied mathematics or a creative arts subject, but not a science subject, had a significant impact on performance in the psychology course over and above the influence of UAI score. [ABSTRACT FROM AUTHOR]

The notion that verbal short-term memory tasks, such as serial recall, make use of information in long-term as well as in short-term memory is instantiated in many models of these tasks. Such models incorporate a process in which degraded traces retrieved from a short-term store are reconstructed, or redintegrated (Schweickert, 1993), through the use of information in long-term memory. This article presents a conceptual and mathematical model of this process based on a class of item-response theory models. It is demonstrated that this model provides a better fit to three sets of data than does the multinomial processing tree model of redintegration (Schweickert, 1993) and that a number of conceptual accounts of serial recall can be related to the parameters of the model. [ABSTRACT FROM AUTHOR]

A major aim of the current research was to determine whether the phonological similarity effect (PSE) remains when the stimuli to-be-recalled were nonwords and to investigate whether the position of overlapping phonemes influences nonword recall. In comparison to phonemically dissimilar nonwords, a facilitative PSE was found when a strict scoring criterion was used to analyse recall accuracy, regardless of whether similarity was defined in terms of stimuli that rhymed (Experiment 1) or that shared common consonant components (C_C, Experiment 3). Also, using a strict scoring criterion, when stimuli shared a common initial consonant and vowel (CV_, Experiment 2), no differences were found between these conditions. Lastly, order accuracy was better for phonemically dissimilar nonwords than any of the similar conditions. Findings are discussed in relation to the 'memory load argument' and the processes involved in nonword recall. Implications for current short-term memory models are discussed and future research directions proposed. [ABSTRACT FROM AUTHOR]

The set-size effect in immediate serial recall is the finding that performance is better when items are repeatedly sampled form the same small pool than when new items are used on every trial. This effect can be thought of as a longterm memory contribution to the immediate serial recall task but the mechanism underlying the effect remains unclear. A single experiment is reported in which word-sets are established in a series of serial recall trials in phase 1. In phase 2 these sets are then tested in a further series of recall trials using pure or mixed sets from phase 1 or entirely new items. The results suggest that repeated presentation of items across trials results in the formation of a 'set concept' which increases the likelihood of correctly recalling an item without influencing order information. Simple item familiarity does not seem to be a factor in explaining the effect. [ABSTRACT FROM AUTHOR]

This study sought to address criticisms aimed at the validity of conclusions reached by implicit learning research via using a simple rapid serial visual presentation design (ruling out partial or correlated knowledge), as well as using psychophysiological measurement to dissociate processing. Subjects (N = 41) were exposed to a cue, which always precede one of two targets (that they responded to via a button press), interspersed amongst series of distractor stimuli. An awareness test, administered post-experimentally allowed classification of aware and unaware subjects. These results were matched by P3 latency and amplitude findings. The presence of a negativity (believed to be a CNV) also provided suggestive evidence for the ability to physiologically detect the presence or absence of behavioural learning. These findings give support to the existence of implicit learning and, in particular, implicate physiological measurement as a highly useful passive online tool for measurement of subject awareness. [ABSTRACT FROM AUTHOR]

A word's orthographic neighborhood is the set of words that differ from the target word by one letter. Both Roodenrys (2009) and Robert et al. (Journal of Psycholinguistic Research, 44, 119-125, 2015) posit that orthographic neighbors are activated when the target word is encountered in tasks such as simple and complex span. The two accounts differ in that the former predicts a beneficial effect of this activation, because it produces feedback activation that helps redintegrate the target word, whereas the latter predicts a detrimental effect, because the need to overcome the greater interference from the larger number of higher-frequency items reduces the processing resources available. Four experiments assess the predictions of these two accounts. Experiments 1 and 2 found a beneficial effect of having a higher- compared with a lower-frequency neighborhood in both a simple and a complex span task. Experiments 3 and 4 found no detrimental effect of having one or more neighbors with higher frequency than the target in both a simple and complex span task. Implications for the two theories are discussed., (© 2024. The Author(s).)

Introduction: Promising evidence is emerging for the procognitive, anti-inflammatory and neuroprotective properties of dietary flavonoids, particularly anthocyanins that provide red, purple and blue plant pigments., Methods and Analysis: The 'Food for Thought' study is a multicentre, 6-month randomised, parallel 3-arm clinical trial. Its primary aim is to investigate whether anthocyanin consumption, either through diet or supplementation, can prevent memory loss progression and improve inflammatory and cardiovascular health in older adults at risk for dementia. Eligible participants will include those aged 60-85 years with a diagnosis of amnestic mild cognitive impairment or with a self-referral of memory concerns and scoring ≤13 on the Memory Index Score within the Telephone Montreal Cognitive Assessment screening test. Participants will be randomised to one of three arms: High anthocyanin ('purple foods') diet (aiming for a target of 250 mg anthocyanins/day); freeze-dried product derived from blackcurrants (250 mg anthocyanins/day); or control (coloured maltose powder). The primary outcome is auditory anterograde memory functioning assessed by the Buschke and Grober Free and Cued Selective Reminding Test-Immediate Recall. Secondary outcomes are additional cognitive functions including processing speed, working memory, aspects of executive functioning (attentional shifting and word generativity) and premorbid estimate as well as subjective memory problems and self-reported depression symptoms. Additional secondary outcomes are blood pressure, inflammatory biomarkers, brain-derived neurotrophic factor, fatty acid profile, apolipoprotein E and polyphenol metabolites, gut microbiota composition and function and vascular and microvascular endothelial function tests. Repeated measures analysis of variance and/or mixed linear modelling will evaluate changes over time, with the inclusion of covariates., Ethics and Dissemination: Ethics approval has been obtained from the Greater Western Human Research Ethics Committee (2021/ETH12083). A Consumer Advisory Group was established to guide and review the protocol and dissemination strategy. The results of this trial are intended to be published in a peer-reviewed journal., Trial Sponsor: National Health and Medical Research Centre Dementia Collaborative Research Centre.Start date of clinical trial: 02 September 2022.Expected end date: 11 October 2024., Trial Registration Number: ACTRN12622000065796., Competing Interests: Competing interests: HB is or has been an advisory board member or consultant to Biogen, Eisai, Eli Lilly, Medicines Australia, Roche and Skin2Neuron. He is a Medical/Clinical Advisory Board member for Montefiore Homes and Cranbrook Care. There are no other conflicts of interest among the other authors., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

The neighbourhood size effect refers to the finding of better memory for words with more orthographic/phonological neighbours than otherwise comparable words with fewer neighbours. Although many studies have replicated this result with serial recall, only one has used serial recognition. Greeno et al. (2022) found no neighbourhood size effect when a large stimulus pool was used and a reverse effect-better performance for small neighbourhood words-when a small stimulus pool was used. We reexamined these results but made two methodological changes. First, for the large pool, we randomly generated lists for each subject rather than creating one set of lists that all subjects experienced. Second, for the small pool, we randomly generated a small pool for each subject rather than using one small pool for all subjects. In both cases, we observed a neighbourhood size effect consistent with results from the serial recall literature. Implications for methodology and theoretical accounts of both the neighbourhood size effect and serial recognition are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

A growing number of studies have shown that on serial recall tests, words with more orthographic/phonological neighbours are better recalled than otherwise comparable words with fewer neighbours, the so-called neighbourhood size effect. Greeno et al. replicated this result when using a large stimulus pool but found a reverse neighbourhood size effect-better recall of words with fewer rather than more neighbours-when using a small stimulus pool. We report three registered experiments that further examine the role of set size in the neighbourhood size effect. Experiment 1 used the large pool from Greeno et al. and replicated their finding of a large-neighbourhood advantage. Experiment 2 used the small pool from Greeno et al. but found no difference in recall between the large and small neighbourhood conditions. Experiment 3 also used a small pool but the small pool was randomly generated for each subject from the large pool used in Experiment 1. This resulted in a typical large neighbourhood advantage. We suggest that set size is not critical to the direction of the neighbourhood size effect, with a large neighbourhood advantage appearing with both small and large pools., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

This paper explores the impact of phonological overlap amongst items on short term memory recall performance by manipulating the type, number and syllabic position of shared phonemes between words in a serial recall task. Roodenrys et al [Roodenrys, S., Miller., L. M., & Josifoski, N. (2022b). Phonemic interference in short-term memory contributes to forgetting but it is not due to overwriting. Journal of Memory and Language, 122 , 104301. https://doi.org/10.1016/j.jml.2021.104301] demonstrated that when the phonemes of a target word also occur in words earlier in the list, recall of the target word is impaired. Two experiments are reported that further examine the nature of this interference effect. Experiment 1 varied the type and number of phonemes shared with the single syllable target word by other list words and found a single shared vowel impaired target word recall performance as much as two shared consonants. Experiment 2 altered the syllabic position of the overlapping phonemes and found shared syllabic position was necessary to impair recall of the target word. It is argued these results show that not all phonological overlap is equally detrimental and specific psycholinguistic conditions are necessary to produce interference that impairs recall performance.

The phonological similarity effect in short-term memory (STM) is the finding that serial recall of lists of similar sounding items is poorer than that of dissimilar sounding items. This is traditionally argued to be due to a detrimental effect on memory for the order of the words in the list and not on memory for the words themselves. Models that propose forgetting from STM is due to interference must invoke an additional compensatory process where the shared element of the words acts as a cue to recall, in order to account for the lack of an effect on memory for the words. However, the possibility of a detrimental effect of phonological similarity on item memory when these compensatory processes are not available has not been investigated. Two experiments (n = 60 and n = 57) in which similarity is operationalized in a way that precludes usage of compensatory processes are reported. The results clearly demonstrate that item recall is poorer for similar lists than dissimilar lists when similarity is defined in this way., (© 2022 The Authors. British Journal of Psychology published by John Wiley & Sons Ltd on behalf of The British Psychological Society.)

Research on the role of dietary anthocyanins in preventing cognitive decline in older adults shows promise. This study investigated the association between usual anthocyanin intake and indices of memory and cognition in 40 older adults diagnosed with mild cognitive impairment that were recruited to a randomized clinical trial. It was hypothesized that daily anthocyanin intake would be similar to healthy older adults and that higher anthocyanin intake would be associated with better cognitive performance. Cognitive performance was assessed using a battery of tests including the Rey Auditory Verbal Learning Test (RAVLT). Dietary intake was assessed through 3-day food records and anthocyanin intake was quantified using the PhenolExplorer food composition database. Multivariate linear regression compared differences in cognitive performance between higher (>10 mg/d) and lower consumers (<10 mg/d). Overall, participants had low median intake of anthocyanins (5.3; interquartile range [IQR], 32.1 mg/d), with the lower consumer group eating negligible anthocyanins (median, 0.13; IQR, 1.5 mg/d), and the higher consumer group eating above the national average (median, 35.5; IQR, 71.5 mg/d). On the RAVLT, the higher anthocyanin consumer group recalled a greater number of words after a short delay and a distracter task (B, 2.07; standard error [SE], 0.93; 95% confidence interval [CI], 0.18-3.96; P = .03) and longer delay of 20 minutes (B, 2.68; SE, 1.11; 95% CI, 0.43-4.94; P = .02); and forgot less words after a long delay of 20 minutes (B, -2.63; SE, 0.63; 95% CI, -3.90 to -1.35; P< .001). Further investigation of the protective role of the usual consumption of dietary anthocyanins for memory and cognition in pathological and normal aging appears warranted. Trial registration: This cross-sectional study uses baseline data from a randomized controlled trial registered with the Australian New Zealand Clinical Trials Registry (ACTRN12618001184268)., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Abnormalities in language processing, psychological distress, and subtle neurodevelopmental features called neurological soft signs (NSS) are expressed by people with dyslexia and those scoring highly on schizotypy. We investigated whether the expression of NSS, distress, and schizotypy predicted dyslexia status. Participants (N = 96, 48 dyslexic) selected to be age and sex matched, completed the Schizotypal Personality Questionnaire, General Health Questionnaire, Neurological Evaluation Scale, and the National Adult Reading Test (NART; a measure of verbal intelligence). Dyslexia status was predicted by higher total NSS and disorganized schizotypy scores in the absence of NART. However, even with the inclusion of NART, disorganized schizotypy remained a significant predictor. The findings suggest that disorganized features of schizotypy could be a significant factor for those with dyslexia. Conversely, more attention needs to be given to developmental language disorders in those who score highly on schizotypy., (© 2021 Institute of Psychology, Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.)

Introduction: Prevalence of cognitive impairment increases with worsening severity of chronic kidney disease (CKD) and majority of end-stage kidney disease (ESKD) patients on dialysis have cognitive impairment. Trends of cognitive function (CF) in this population are less well known with published studies reporting conflicting results., Methods: We assessed CF in a cohort of non-dialysis CKD and ESKD patients undergoing dialysis using modified mini-mental state examination (3MS), trail-making test (TMT-A & B) scores and Stroop task, and evaluated demographics, comorbidities and depression using Beck depression inventory at baseline. We repeated tests of CF and depression ≥ 1-year after baseline in both groups and compared change scores in CF and depression between ESKD/ CKD sub-groups. Among ESKD patients we compared change scores between patients with dialysis vintage of <1-year and >1-year. Analysis of covariance was used to adjust for the effect of age on these change scores., Results: At baseline (N = 211), compared to CKD (N = 108), ESKD (N = 103) patients had significantly worse CF based on 3MS and TMT-A & B scores, and depression scores. On follow-up (N = 160) 3MS scores, especially the memory subscale significantly improved in ESKD, but worsened in CKD, with no significant changes in TMT A /TMT-B, or depression scores after adjusting for age. Among ESKD patients, 3MS, especially memory subscale improved in patients with dialysis vintage <1-year compared to >1-year. The 51 patients who discontinued after baseline assessment had worse baseline CF scores suggesting differential attrition., Conclusion: Though baseline cognitive scores were worse in ESKD patients on dialysis, compared to CKD, their 3MS, especially memory subscale improved on follow-up. Among ESKD patients, the improvement was significant only in patients who have been on dialysis for less than one-year which may indicate a beneficial effect of clearance of uraemic toxins. Differential attrition of study subjects may have impacted the observed results., Competing Interests: This project was not funded by any external or departmental sponsor. The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

Background & Aims: Vascular function, blood pressure and inflammation are involved in the pathogenesis of major chronic diseases, including both cardiovascular disease (CVD) and mild cognitive impairment (MCI). This study investigated the effects of food anthocyanins on microvascular function, 24-h ambulatory blood pressure (ABP) and inflammatory biomarkers in older adults with MCI., Methods and Results: Thirty-one participants with MCI [19 female, 12 male, mean age 75.3 (SD 6.9) years and body mass index 26.1 (SD 3.3) kg/m 2 ], participated in a randomized, controlled, double-blind clinical trial (Australian New Zealand Clinical Trials Registry: ACTRN12618001184268). Participants consumed 250 mL fruit juice daily for 8 weeks, allocated into three groups: a) high dose anthocyanins (201 mg); b) low dose anthocyanins (47 mg); c) control. Microvascular function (Laser Speckle Contrast Imaging combined with a post-occlusive reactive hyperaemia test), 24h ABP and serum inflammatory biomarkers were assessed before and after the nutritional intervention., Results: Participants in the high anthocyanins group had a reduction in serum tumor necrosis factor alpha (TNF-α) (P = 0.002) compared to controls and the low anthocyanins group (all P's > 0.05). Serum IL-6, IL-1β, c-reactive protein, and parameters of microvascular function and 24h ABP were not altered by any treatment., Conclusion: A daily high dose of fruit-based anthocyanins for 8 weeks reduced concentrations of TNF-α in older adults with MCI. Anthocyanins did not alter other inflammatory biomarkers, microvascular function or blood pressure parameters. Further studies with a larger sample size and longer period of follow-up are required to elucidate whether this change in the immune response will alter CVD risk and progression of cognitive decline., Competing Interests: Declaration of competing interest The authors have nothing to disclose., (Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)

Background & Aims: Postprandial metabolic imbalances are important indicators of later developing cardiovascular disease (CVD). This study investigated the effects of food anthocyanins on vascular and microvascular function, and CVD associated biomarkers following a high fat high energy (HFHE) meal challenge in overweight older adults., Methods: Sixteen subjects (13 female, 3 male, mean age 65.9 SD 6.0 and body mass index 30.6 kg/m 2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal., Results: Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine., Conclusion: Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD., Competing Interests: Conflict of interest The authors declare no conflict of interest., (Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)

Introduction: We aimed to investigate the association between schizotypy and intentionality bias, the tendency to interpret ambiguous actions as being intentional, for social and non-social actions separately. This bias contributes to interpersonal difficulties, and has been associated with psychotic symptoms, such as delusions. However, results have been inconsistent for an association between putative psychosis proneness, schizotypy, and intentionality bias. Further, the multidimensional nature of schizotypy has not been considered. Agreeableness was measured to examine the specificity of the relationship, and inhibition to examine its potential role as a mediator., Methods: Two online studies are reported ( n  = 280 and n  = 163) in which participants made intentionality judgements about ambiguous actions described in sentences. They also completed questionnaire measures of schizotypy and agreeableness, and inhibitory efficiency (a sentence completion task)., Results: Schizotypy was associated with perceiving ambiguous actions as intentional, particularly in social contexts, after controlling for agreeableness. The association with social intentionality was stronger for schizotypy subscales capturing paranoia and unusual beliefs. Inhibitory efficiency as not a significant predictor of intentionality bias., Conclusion: These finding suggest intentionality biases for social and non-social events are distinguishable. In relation to schizotypy, social situations appear to generate perceptions of intentionality. Intentionality bias represents a phenotypic cognitive risk for psychosis which should be further investigated.

Objectives: Lower health literacy (HL) is associated with poor outcomes in patients with kidney disease. Since HL matches the patient's competencies with the complexities of the care package, the level of HL sufficient in earlier stages of chronic kidney disease (CKD) may be inadequate for patients with end-stage kidney disease (ESKD) on dialysis. We aimed to analyse the HL profile of patients with ESKD and non-dialysis CKD and examine if there were significant associations with covariates which could be targeted to address HL deficits, thereby improving patient outcomes., Design and Setting: Cross-sectional study of patients with CKD and ESKD from a single Australian health district., Methods: We assessed the HL profile of 114 patients with CKD and 109 patients with ESKD using a 44-item multidomain Health Literacy Questionnaire (HLQ) and examined its association with demographic factors (age, gender, race), smoking, income, education, comorbidities, carer status, cognitive function and depression. Using multivariable logistic regression models, HL profiles of patients with CKD and ESKD were evaluated after adjusting for covariates., Results: Patients with ESKD had similar demographics and educational levels compared with patients with CKD. ESKD had significantly higher frequency of vascular disease, cognitive impairment and depression. Patients with ESKD had better HL scores for the social support domain (37.1% vs 19.5% in higher HLQ4 tertile, p=0.004), whereas all other HL domains including engagement with healthcare providers were comparable to CKD. Depression was independently associated with nearly all of the HL domains (HLQ1: OR 2.6, p=0.030; HLQ2: OR 7.9, p=<0.001; HLQ3: OR 7.6, p<0.001; HLQ4: OR 3.5, p=0.010; HLQ5: OR 8.9, p=0.001; HLQ6: OR 3.9, p=0.002; HLQ7: OR 4.8, p=0.001; HLQ8: OR 5.3, p=0.001) and education with HL domains relevant to processing health-related information (HLQ8: OR 2.6, p=0.008; HLQ9: OR 2.5, p=0.006)., Conclusions: Despite very frequent interactions with health systems, patients with ESKD on dialysis did not have higher HL in engagement with health providers and most other HL domains, compared with patients with CKD. Strategies promoting patient-provider engagement and managing depression which strongly associates with lower HL may address the impact of HL deficits and favourably modify clinical outcomes in renal patients., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Queen Garnet plum (QGP), known for its high levels of anthocyanins, is a hybrid of the Japanese plum developed in Queensland, Australia. Anthocyanins provide the red, blue, and purple pigments in plants with demonstrated beneficial health effects. This study hypothesized that low-dose anthocyanin QGP intake will have a significant positive effect on cognition, blood pressure, and gut microbiota in healthy older adults. A randomized crossover trial was conducted to determine the effect and within subject variance on cognition and 24 hr. ambulatory blood pressure in older adults without cognitive impairment following daily consumption of 200 mL low-dose anthocyanin (5 mg/100 g) QGP nectar (intervention) or raspberry cordial (control). Secondary outcomes included inflammatory markers (C-reactive protein), nerve growth factor (BDNF), and gut microbiota (16S rRNA gene sequencing). Twenty-eight participants (55+ years) were recruited. Each randomized treatment arm lasted for 8 weeks with a 4-week washout period. Cognition, blood pressure, and urine samples were measured at each visit (5 total) while blood and fecal samples were collected at baseline, 8 weeks, and 20 weeks. Repeated-measures ANOVA was used to analyze the data. Across the treatments, no significant difference was observed for the different domains of cognition, blood pressure, or anti-inflammatory biomarkers. No intervention effect was found for genera or class of gut microbes. Low anthocyanin nectar derived from the QGP did not have any significant effects on cognition, blood pressure, or gut microbiota in healthy older adults., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Semantic processing underpins the organization of verbal information for both storage and retrieval. Deficits in semantic processing are associated with both the risk for and symptoms presented in schizophrenia. However, studies are mixed and could reflect the confounding effects of medication and symptom heterogeneity. Therefore, we considered whether two risk phenotypes, positive schizotypy and hallucinatory predisposition, present in the general population were associated with differential responding profiles for a semantic processing task. One hundred and eighty-three participants completed the Schizotypal Personality Questionnaire, Launay-Slade Hallucination Scale, National Adult Reading Test, a handedness measure, and a computerized semantic relatedness judgment task. Pairs of words were related through their dominant or subordinate meanings, or unrelated. Participants were divided into four groups using a mean split on cognitive-perceptual (positive) schizotypy and hallucination proneness. Significant differences between groups were found for reaction time on the semantic relatedness task, with the high cognitive-perceptual schizotypy groups responding significantly slower to all word pairs compared to their low scoring counterparts. There was some evidence that high hallucination proneness was associated with significantly faster reaction times which may reflect disinhibitive processes, however additional support is required. The results suggest that these two components of psychosis risk are associated with different patterns of responding to semantic processing. More diffuse activation of semantic information appeared to be associated with positive schizotypy, while those predisposed to hallucinations appeared to respond quicker. These results have significant implications in the re-conceptualization of hallucination proneness as distinct from positive schizotypy. Additional research is required to investigate the association between psychotic-like experiences separate from personality variables such as positive schizotypy and semantic processing., (Copyright © 2020 de Leede-Smith, Roodenrys, Horsley, Matrini, Mison and Barkus.)

Objective : There is literature to suggest that anxious individuals may be lonely. Attentional bias for threat (ABT), a mechanism implicated in the core symptoms of anxiety, has been linked to loneliness in a separate line of work. The primary aim of this study was to examine the role of loneliness in the association between ABT and anxiety. Method : An unselected sample of 260 individuals (196 Female; Mean Age = 22.43) completed measures of loneliness, ABT (a dot probe task), and anxiety. Two possible models of the role of loneliness in the ABT-anxiety link were tested using hierarchical regression analysis: (1) A moderation model (the ABT-anxiety link is moderated by loneliness), and (2) A proxy model (the ABT-anxiety link is better explained by loneliness). Results : In support of the latter model, ABT no longer predicted anxiety after the effects of loneliness had been accounted for. Additionally, ABT was associated with anxiety only when indexed using sadness-related scenes (but not fear-related scenes). Conclusions : Loneliness may be one important source of exaggerated threat appraisals which underpin the association between ABT and anxiety. Different classes of negative stimuli may be differentially sensitive to anxiety and should be a point of consideration in future research.

The present study explored the influences of semantic features in immediate serial recall in order to further examine the involvement of semantic knowledge in short-term memory. The number of semantic features (NoF) was found to have a positive effect on short-term recall where high NoF words were remembered better than low NoF words (Experiment 1). This effect was replicated in a second experiment and was found to persist even after controlling for a potential confound (number of distinguishing features). It was further found that having more distinctive features facilitated recall performance of words whose representation was semantically poorer (Experiment 3). These results provide additional evidence of semantic influences in short-term memory and demonstrate that the organisation of semantic knowledge is reflected in short-term memory performance.

Complex scenes from standardized stimuli databases such as the International Affective Picture System (IAPS) are organized dimensionally rather than discretely. Further, the potentially unique function of socially relevant scenes is often overlooked. This study sought to identify discrete categories of complex scenes from the IAPS and to explore if there were qualitative features that make the emotional content of some social scenes identifiable with higher levels of agreement. One hundred and three participants (53.4% female, mean age 24.4) judged 118 IAPS scenes as reflecting fear, happy, sad, or neutral. A second judgment study was conducted with a separate group of participants ( N = 117; 79.2% female; mean age 30.41) to further characterize valid affective scenes across the full range of basic emotions. Sixty images received agreement on their emotional category from >70% of judges and were considered valid. IAPS identifier codes for these images are available for reference (along with the supplementary material from the second judgment study), organized by emotional and social content. An incidental observation was such that compared to nonsocial scenes, lower agreement rates were observed for social scenes across the board. Qualitative features of social scenes that were classified into emotional categories based on higher levels of agreement are discussed.

Objective: The electroencephalogram (EEG) has been widely used in AD/HD research. The current study firstly aimed to replicate a recent trend related to EEG theta/beta ratio (TBR) in children and adolescents. Also, the study aimed to examine the value of resting EEG activity as biomarkers for executive function (EF) in participants with AD/HD., Method: Fifty-three participants with AD/HD and 37 healthy controls were recruited. Resting EEG was recorded with eyes closed. Participants with AD/HD additionally completed EF tasks via the Cambridge Neuropsychological Test Automated Battery., Results: TBR did not differ between groups; however, TBR was positively correlated with inattentive symptoms in AD/HD. Other correlations were found between EEG activity and neuropsychological functions including spatial planning and decision making in the AD/HD group., Conclusion: The results do not support the diagnostic value of TBR. Instead, given the heterogeneous features, the results support the prognostic value of EEG in AD/HD.

Background: In patients with end stage kidney disease (ESKD) on dialysis, treatment non-adherence is common and results in poor health outcomes. However, the clinical benefits of interventions to improve adherence in dialysis patients are difficult to evaluate since trialled interventions and reported outcomes are highly diverse/ heterogeneous. This review summarizes existing literature on randomized controlled trials (RCTs) evaluating adherence interventions in ESKD patients focusing on the intervention category, outcome efficacy and persistence of benefit beyond the intervention., Methods: We performed electronic database searches in Medline, Embase & Cochrane CENTRAL upto 1st July 2018 for RCTs evaluating interventions to improve diet, fluid, medication or dialysis adherence in ESKD patients. Study characteristics including category of interventions, outcomes, efficacy and follow-up were assessed. Meta-analysis was used to compute pooled estimates of the effects on the commonest reported outcome measures., Results: From 1311 citations, we included 36 RCTs (13 cluster-randomized trials), recruiting a total of 3510 dialysis patients (mean age 55.1 ± 5.8 years, males 58.1%). Overall risk of bias was 'high' for 24 and of 'some concern' for 12 studies. Most interventions (33 trials, 92%) addressed patient related factors, and included educational/cognitive (N = 11), behavioural / counselling (N = 4), psychological/affective (N = 4) interventions or a combination (N = 14) of the above. A majority of (28/36) RCTs showed improvement in some reported outcomes. Surrogate measures like changes in phosphate (N = 19) and inter-dialytic weight gain (N = 15) were the most common reported outcomes and both showed significant improvement in the meta-analysis. Sixteen trials reported follow-up (1-12 months) beyond intervention and the benefits waned or were absent in nine trials within 12 months post-intervention., Conclusions: Interventions to improve treatment adherence result in modest short-term benefits in surrogate outcome measures in dialysis patients, but significant improvements in trial design and outcome reporting are warranted to identify strategies that would achieve meaningful and sustainable clinical benefits., Limitations: Poor methodological quality of trials. Frequent use of surrogate outcomes measures. Low certainly of evidence., Competing Interests: The authors have declared that no competing interests exist.

Objective: This study explored the relationships between resting-state electroencephalogram (RS-EEG) localized activation and two important types of executive functions (EF) to extend the prognostic utilization of RS-EEG in children with Attention-Deficit/Hyperactivity Disorder (AD/HD). Also, the role of central nervous system (CNS) arousal in the relationships was examined., Methods: Fifty-eight children with AD/HD participated in the study. RS-EEG localized activation was derived from spectral power differences between EEG in eyes-closed and eyes-open conditions. CNS arousal was measured based on alpha band power. Common and everyday EF scores were obtained as EF outcomes., Results: Frontal delta activation predicted common EF ability and posterior alpha activation predicted everyday EF. A serial mediation analysis found that lower CNS baseline arousal was related to greater arousal and delta activation in series, which in turn related to worse common EF. A follow-up study found that baseline arousal was related to larger interference cost., Conclusions: RS-EEG is indicative of individual differences in two important types of EF in children with AD/HD. Lower CNS arousal may be a driving force for the poorer common EF performance., Significance: The current study supports prognostic utilization of RS-EEG and AD/HD models that take resting brain activity into consideration in children with AD/HD., (Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)

The author acknowledges an honest error in the tables of the appendix of this article. Table 4 actually refers to the results of Experiment 3, and Table 5 refers to the results of Experiment 2.

We carried out a series of experiments on verbal short-term memory for lists of words. In the first experiment, participants were tested via immediate serial recall, and word frequency and list set size were manipulated. With closed lists, the same set of items was repeatedly sampled, and with open lists, no item was presented more than once. In serial recall, effects of word frequency and set size were found. When a serial reconstruction-of-order task was used, in a second experiment, robust effects of word frequency emerged, but set size failed to show an effect. The effects of word frequency in order reconstruction were further examined in two final experiments. The data from these experiments revealed that the effects of word frequency are robust and apparently are not exclusively indicative of output processes. In light of these findings, we propose a multiple-mechanisms account in which word frequency can influence both retrieval and preretrieval processes.

The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT). A behavioral disassociation was found - compared to CT, ET showed more difficulty in inhibiting surrounding stimuli but had less day-to-day inhibitory issues measured by BRIEF. There was no significant group difference on response inhibition. The results support the prognostic value of TBR in AD/HD. Elevated TBR may be an inhibitory biomarker; further studies are needed to explore the behavioral implications in patients without elevated TBR., (Copyright © 2017 Elsevier B.V. All rights reserved.)