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Purpose: The aim of this study was to translate and cross-cultural adapt the international prostate symptom score (IPSS) and benign prostatic hyperplasia impact index (BII) into simplified Chinese for mainland Chinese patients with benign prostatic hyperplasia (BPH).Methods: The original English IPSS and BII were translated into simplified Chinese versions, based on cross-cultural adaptation guidelines. Internal consistency was evaluated with Cronbach’ α, then test-retest reliability with intraclass correlation coefficients (ICCs) in stable patients. The validity of these two adaptations was tested by the correlation between the IPSS, and BII with visual prostate symptom score (VPSS), and 36 items Short Form Health Survey (SF-36). The floor and ceiling effects were calculated by the proportion of participants who obtained the highest and lowest possible score.Results: A total of 105 native Chinese-speaking patients with BPH were enrolled. Cronbach’ α were over 0.75 for the simplified Chinese IPSS (IPSS 0.815; IPSS-symptom 0.782), and 0.709 for the simplified Chinese BII, indicating acceptable internal consistency. The ICCs for the test-retest reliability were over 0.75 (IPSS, r = 0.836; IPSS-symptom, r = 0.801; IPSS-quality of life, r = 0.794; BII, r = 0.758), indicating excellent test-retest reliability. There were very good positive correlations between IPSS and BII (r = 0.605), as well as VPSS (r = 0.634), and very good or good negative correlations between IPSS-Qol and SF-36 physical functioning (r = -0.621), and vitality (r = -0.659), and between BII and SF-36 physical functioning (r = -0.421). No floor or ceiling effect was detected in the simplified Chinese IPSS and BII.Conclusions: This study indicates that the simplified Chinese IPSS and BII are reliable and valid measurement of the symptom and quality of life among Chinese patients with BPH, which is likely to be widely used in this population.

Systematic review of cross-cultural adaptation.To perform a systematic review of cross-cultural adaptations of the Neck Disability Index (NDI) and to give a critical assessment to improve its translation.The NDI is used to assess functional capacity and physical activity in patients with neck pain, but the quality of its cross-cultural adaptations has not been systematically reviewed.PubMed, Cochrane Library, and EMBASE were searched up through 2013 to identify studies of cross-cultural NDI adaptations. Search terms were "Neck Disability Index" or "NDI" and "cross-cultur*" or "cultur*" or "valid*" or "equivalence" or "transl*." Data were extracted and study quality was assessed.Twenty-four different NDI versions were identified from 14 different languages/cultures. Most reported forward and back translation and pretesting, but sample size was a problem for most studies. The Cronbach α was generally acceptable, and 13 versions met the criterion of reliability by reporting an intraclass correlation coefficient of 0.70 or more, although some versions did not reach the minimal intraclass correlation coefficient. Eleven versions tested ceiling and floor effects, but only 1 Japanese version reported a floor effect. No study reported interpretability, and none provided the minimal important change or minimal important difference.The Arabic, Italian, and Thai versions were of higher quality than the other versions according to the overall assessment of the 3 checklists. The Catalan, Chinese, Japanese, Korean, Thai, and Turkish versions need more research according to the Quality Criteria for Psychometric Properties of Health Status Questionnaire. Pretest sample size was not large enough in most cases.1.

Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery.Methods. Randomized controlled trials (RCTs) data of traditional Chinese herbs combined with surgery for male varicocele fertility versus surgery were collected by searching the Cochrane Library, Embase, PubMed, and Chinese databases. The risk of bias was assessed using Cochrane Handbook. Study outcomes were presented as risk ratios (RRs) for dichotomous data.Results. Seventeen of 72 potentially relevant trials met the inclusion criteria. The methodological qualities of the RCTs were low. Compared with the surgery group, the traditional Chinese herb combined with surgery group had superiority in pregnancy rate at 3-month (RR=1.76, andP=0.008), 6-month (RR=1.58, andP=0.0005), and 2-year (RR=1.58, andP=0.0005) follow-ups. No RCT was found to describe the side effects.Conclusion. On considering the low methodological quality of RCTs, there was no enough evidence on traditional Chinese herb with surgery for male varicocele infertility, and more high-quality RCTs of large sample sizes are required.

Spinal cord injury (SCI) is a devastating condition affecting young, healthy individuals worldwide. Existing agents have inadequate therapeutic efficacy, and some are associated with side effects. Our objective is to summarize and critically assess the neurological recovery and antioxidant effects of curcumin for treatment of SCI in rat models. PubMed, Embase, and Chinese databases were searched from their inception date to February 2014. Two reviewers independently selected animal studies that evaluated neurological recovery and antioxidant effects of curcumin, compared to placebo, in rats with SCI, extracted data, and assessed the methodological quality. A pair-wise analysis and a network meta-analysis were performed. Eight studies with adequate randomization were selected and included in the systematic review. Two studies had a higher methodological quality. Overall, curcumin appears to significantly improve neurological function, as assessed using the Basso, Beattie, Bresnahan (BBB) locomotor rating scale (four studies, n=132; pooled mean difference [MD]=3.09; 95% confidence interval [CI], 3.40-4.45; p=0.04), in a random-effects model and decrease malondialdehyde (MDA) using a fixed-effects model (four studies, n=56; pooled MD=-1.00; 95% CI=-1.59 to -0.42; p=0.00008). Effect size, assessed using the BBB scale, increased gradually with increasing curcumin dosage. The difference between low- and high-dose curcumin using the BBB scale was statistically significant. Neurological recovery and antioxidant effects of curcumin were observed in rats with SCI despite poor study methodological quality.

To summarize and critically assess the effificacy of Eastern and Western manipulative therapies for the treatment of neck pain in adults. A search of PubMed/MEDLINE, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, EMBASE, etc. from their inception date to January 2014 with Chinese, Japanese, and Korean databases. Two reviewers independently selected randomized controlled trials (RCTs) with negative control or blank control, extracted data and assessed methodological quality. Meta-analysis and levels of evidence were performed by Revman5.1 and Grades of Recommendations Assessment, Development and Evaluation (GRADE) approach. Nineteen clinical trials with adequate randomization were included in this review, 11 of them had a low risk of bias. The primary outcome for short-term pain had no significant differences, however, the secondary outcome, only the Numerical Pain Rating Scale (NPRS) score of intermediate-term [n=916, pooled mean differences (MD) =–0.29, P=0.02], the Neck Disability Index (NDI) score of short-term (n=1,145, pooled MD=–2.10, P