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4 results on '"Rong, Zhenhua"'

1. Knockdown of USP8 Inhibits the Growth of Lung Cancer Cells

Author

Rong,Zhenhua, Zhu,Zongmin, Cai,Shihua, and Zhang,Bingqing

Subjects
Cancer Management and Research
Abstract

Zhenhua Rong,1 Zongmin Zhu,2 Shihua Cai,3 Bingqing Zhang4 1Minimally Invasive Surgery Oncology, The People’s Hospital of Caoxian, Heze, Shandong, People’s Republic of China; 2Department of Pharmacology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, People’s Republic of China; 3Department of Outpatient, Heze Municipal Hospital, Heze 274000, Shandong, People’s Republic of China; 4Department of Respiratory Medicine, Heze Municipal Hospital, Heze 274000, Shandong, People’s Republic of ChinaCorrespondence: Bingqing ZhangDepartment of Respiratory Medicine, Heze Municipal Hospital, No. 2888 Caozhou Road, Peony District, Heze 274000, Shandong, People’s Republic of ChinaEmail hzzhangbq@163.comPurpose: Lung cancer is the deadliest tumor in the world. This study aimed to investigate the effection of USP8 on the proliferation and growth of NSCLC cells.Methods: The proliferation, migration, invasion, cell cycle progression, and apoptosis of A549 and H1299 cells were evaluated with CCK8, colony formation, scratch, transwell, and flow cytometry experiments. Furthermore, the expression of cell cycle- and apoptosis-related proteins was detected by western blot.Results: Knockdown of USP8 inhibited the proliferation, migration, invasion, and cell cycle progression of A549 and H1299 cells, and promoted the apoptosis. The results of western blot indicated that knockdown of USP8 down-regulated the expression of Cyclin D1, CDK4, CDK6, p-AKT, and Bcl2, and up-regulated the expression of Bax.Conclusion: Knockdown of USP8 inhibited the proliferation of human lung cancer cells by regulating cell cycle- and apoptosis-related proteins. USP8 may be a therapeutic target for lung cancer.Keywords: apoptosis, lung cancer, PI3K/AKT pathway, proliferation, USP8

Published
2020

2. Safety and clinical outcomes of computed tomography‐guided percutaneous microwave ablation in patients aged 80 years and older with early‐stage non‐small cell lung cancer: A multicenter retrospective study

Author

Han, Xiaoying, primary, Yang, Xia, additional, Huang, Guanghui, additional, Li, Chunhai, additional, Zhang, Licheng, additional, Qiao, Yuanxun, additional, Wang, Chuntang, additional, Dong, Yuting, additional, Chen, Xiangming, additional, Feng, Qingliang, additional, Wang, Chuandai, additional, Rong, Zhenhua, additional, Ding, Kun, additional, Wei, Zhigang, additional, Ni, Yang, additional, Wang, Jiao, additional, Li, Wenhong, additional, Meng, Min, additional, and Ye, Xin, additional

Published
2019
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4. Effect of CT-guided microwave ablation for non-small cell lung cancer combined with severe chronic obstructive pulmonary disease.

Author

Rong Z, Ji Y, Dai F, Zhang F, Jiao Y, and Liu Y

Abstract

Objective: To investigate the perioperative complications and safety of microwave ablation (MA) therapy for patient's non-small cell lung cancer (NSCLC) combined with severe chronic obstructive pulmonary disease (COPD)., Methods: A total of 28 patients with NSCLC combined with severe COPD in our center were analyzed for complications during MA therapy and post-treatment outcomes., Results: All patients were successfully ablated by puncture, with a tumor efficiency of 85.7% and no death within 30 days. The tumor tissues showed hypodense changes, cavitation, and decreased CT values when the CT was reexamined 24 hours after surgery. A total of 24 patients showed different surgery-related complications, and were cured after targeted treatments. During the follow-up, the lung tumor disappeared, while the fibrous scars and foci as well as pulmonary cavity still remained. CT imaging examination showed there was no enhancement in the tissue after resection., Conclusion: In this study, we confirmed that the complications of NSCLC combined with severe COPD after MA were manageable, safe and effective., Competing Interests: None., (AJTR Copyright © 2021.)

Published
2021

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