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1. A pilot study into the use of Continuous Venous Hyperfiltration to manage patients in a critical state with dysregulated inflammation

Author

Moguel-González, M.A., García Benito, G., Javier Arroyo Fernández, F., Ruiz Rondán, J., Márquez Rodríguez, C., Melendez Leal, E., Carnota Martín, A., Piña Gómez, A., Ramírez Ogalla, I., Cabezuelo Galache, E., Fernández Mangas, C., Muñoz Alcantara, M., Mato Ponce, M., Pérez Bustamante, F.J., Pérez Pérez, A., Ramón Ferri Ferri, J., Gonzálvez Galinier, Á., De Antonio del Barrio, P., Jiménez Pérez, I., García-Hernández, R., Espigares López, M.I., García-Palacios, M.V., Gámiz Sánchez, R., Miralles-Aguiar, F., Calderón Seoane, E., Pernia Romero, A., and Torres, L.M.

Published
2019
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2. Estudio piloto sobre el uso de la Hiperfiltración Venosa Continua para el manejo de pacientes en estado crítico con inflamación desregulada

Author

Moguel-González, M.A., García Benito, G., Javier Arroyo Fernández, F., Ruiz Rondán, J., Márquez Rodríguez, C., Melendez Leal, E., Carnota Martín, A., Piña Gómez, A., Ramírez Ogalla, I., Cabezuelo Galache, E., Fernández Mangas, C., Muñoz Alcantara, M., Mato Ponce, M., Pérez Bustamante, F.J., Pérez Pérez, A., Ramón Ferri Ferri, J., Gonzálvez Galinier, Á., De Antonio del Barrio, P., Jiménez Pérez, I., García-Hernández, R., Espigares-López, M.I., García-Palacios, M.V., Gámiz Sánchez, R., Miralles-Aguiar, F., Calderón Seoane, E., Pernia Romero, A., and Torres, L.M.

Published
2019
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4. Changes in the treatment strategy following intracoronary pressure wire in a contemporaneous real-life cohort of patients with intermediate coronary stenosis. Results from a nationwide registry

Author

Rodriguez Leor, O, primary, Toledano, B, additional, Lopez Palop, R, additional, Rivero, F, additional, Brugaletta, S, additional, Linares, J A, additional, Puigfel, M, additional, Sadaba, M, additional, Vaquerizo, B, additional, Rondan, J, additional, Gomez, I, additional, Saez, R, additional, Planas, A, additional, Lozano, F, additional, and Perez De Prado, A, additional

Published
2022
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5. Effect on cholesterol remnants and residual lipid risk with PCSK9 inhibitors: the LIPID-REAL Registry

Author

Fernandez Del Olmo, R, primary, Cordero, A, additional, Cortez Quiroga, G, additional, Romero-Menor, C, additional, Facila, L, additional, Rondan, J, additional, Bello Mora, M C, additional, Sandin, M, additional, Valle, A, additional, Freixa, R, additional, Blanch, P, additional, Baneras, J, additional, Rodriguez-Manero, M, additional, and Gonzalez-Juanatey, J R, additional

Published
2022
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6. Influence of the speed of deflation of the stent delivery system in the myocardial blush and ST-segment resolution in primary angioplasty: a randomized study

Author

Lozano Martinez-Luengas, I, primary, Cuellas, C, additional, Vega, B, additional, Fernandez-Vazquez, F, additional, Rondan, J, additional, Maria Lopez-Benito, M, additional, Vegas, J M, additional, Benito, T, additional, Samaniego, B, additional, Minguito Carazo, C, additional, Hernandez, E, additional, Garcia Ruiz, J M, additional, Linares, R, additional, Segovia, E, additional, and Perez De Prado, A, additional

Published
2021
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8. [Impact of COVID-19 on ST-segment elevation myocardial infarction care. The Spanish experience]

Author

Rodriguez-Leor O, Cid-Alvarez B, Perez de Prado A, Rossello X, Serrador A, Lopez-Palop R, Martin-Moreiras J, Rumoroso J, Cequier A, Ibanez B, Cruz-Gonzalez I, Romaguera R, Moreno R, Villa M, Ruiz-Salmeron R, Molano F, Sanchez C, Munoz-Garcia E, Inigo L, Herrador J, Gomez-Menchero A, Caballero J, Ojeda S, Cardenas M, Gheorghe L, Oneto J, Morales F, Valencia F, Ruiz J, Diarte J, Avanzas P, Rondan J, Peral V, Pernasetti L, Hernandez J, Bosa F, Lorenzo P, Jimenez F, Jimenez-Mazuecos J, Lozano F, Moreu J, Novo E, Robles J, Moreiras J, Fernandez-Vazquez F, Amat-Santos I, Gomez-Hospital J, Garcia-Picart J, Blanco B, Regueiro A, Carrillo-Suarez X, Tizon H, Mohandes M, Casanova J, Agudelo-Montanez V, Munoz J, Franco J, Del Castillo R, Salinas P, Elizaga J, Sarnago F, Jimenez-Valero S, Rivero F, Oteo J, Alegria-Barrero E, Sanchez-Recalde A, Ruiz V, Pinar E, Planas A, Ledesma B, Berenguer A, Fernandez-Cisnal A, Aguar P, Pomar F, Jerez M, Torres F, Garcia R, Frutos A, Nodar J, Garcia K, Saez R, Torres A, Telleria M, Sadaba M, Minguez J, Merchan J, Portales J, Trillo R, Aldama G, Fernandez S, Santas M, Perez M, Working Group on the Infarct Code of the Interventional Cardiology, and Association of the Spanish Society of Cardiology Investigators

Abstract

INTRODUCTION AND OBJECTIVES: The COVID-19 outbreak has had an unclear impact on the treatment and outcomes of patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to assess changes in STEMI management during the COVID-19 outbreak. METHODS: Using a multicenter, nationwide, retrospective, observational registry of consecutive patients who were managed in 75 specific STEMI care centers in Spain, we compared patient and procedural characteristics and in-hospital outcomes in 2 different cohorts with 30-day follow-up according to whether the patients had been treated before or after COVID-19. RESULTS: Suspected STEMI patients treated in STEMI networks decreased by 27.6% and patients with confirmed STEMI fell from 1305 to 1009 (22.7%). There were no differences in reperfusion strategy (> 94% treated with primary percutaneous coronary intervention in both cohorts). Patients treated with primary percutaneous coronary intervention during the COVID-19 outbreak had a longer ischemic time (233 [150-375] vs 200 [140-332] minutes, P

Published
2020

12. Adiponectin: An emerging cardiovascular risk factor. The REFERENCE study | Adiponectina, un factor de riesgo cardiovascular emergente. Estudio REFERENCE

Author

Barrios Alonso, V., Gómez-Huelgas, R., Rodríguez, R., Pedro de Pablos Velasco, Madruga, F., Velasco, E., Giménez, R., Rubio, J. M., López, J. A., Toril, J., Ordóñez, A., Yoldi, A., Montagud, J. B., Pinar, J., Fernández, M. L., Gómez, R., Sánchez, A., Martín, J. A., Mateos, L., Díaz, J. A., Suárez, M. A., Saban, J., Arroyo, R., López, J., Fontanals, C., López, A., Marín, R., Chacón, A., Carretero, J. F., Hernández, C., Pérez, L., Villar, M. R., Villar, J. R., Gorgojo, J. J., Barroso, E., Álvarez, P., Campillo, M., Camafort, M., Mazzanti, G., Garre, J., Morales, C., Conde, F. J., Gómez, P., Fernández, F., Suárez, S., Villarroel, M. T., Salgado, F. M., Egido, J., Enjuto, J., Gargallo, M. A., García, J. A., Azcona, L. M., Zamorano, J. L., Candel, I., Serra, V., García, A. M., Luis, D., Romero, E., Guerra, J. M., Gómez, F. J., Fuertes, J., Daniel, C., Gunther, S. J., Bellido, D., Yañez, J. C., Soto, F., Rigueiro, P., García, J. M., Díaz, J. L., Sotres, G., Rondan, J. J., Aziz, A., Barriales, V., Asensio, F., Richard, J. M., García, S., Rodrigo, A., Pérez, J., Ruiz, P., Angel, J., Gascueña, R., Ortiz, R., Rayo, M., Martínez, E., González, O., Ortiz, A., Gómez, L. F., Donnay, S., Melehi, D., Horcajo, P., García, F., Gómez, J., Calderón, A., Fernández, M. C., Pujadas, R., Rafael, J., Alfani, O., Virgos, G., Elsaheb, M., Recio, J., Montull, S., Abardia, X., Sucunza, N., Borrallo, R. M., Palos, M. A., Fernández, L. A., Arribas, J. M., Quintas, L., Camacho, I., Montes, P. M., Novales, J. A., Catalán, J. I., Arteaga, R., Ezcurdia, J., Moreno, C., Morillas, M., García, H., Ribas, M., Ortiz, J., Segura, I., Soler, J., Ripoll, T., Fosch, J., Moreno, R., Domenech, M., Antonio, M. T., Viguera, J., Paytubi, C., Blanch, P., Cuatrecasas, G., Gómez, J. M., Laguna, A., Mayos, J., Lapuebla, M. C., Morales, A., Silva, C., Taberna, S., Cordero, A., Pérez, S., Madariaga, I., Elejalde, J. I., Ancin, R., Tiberio, G., Gracia, M. L., Berdun, M. A., García, A., Gayán, R., Sanz, A., Férriz, P., Piedecausa, M. M., Toral, A., Hernández, E., Carnero, A., Arribas, J., Hernández, A., García, B., Gonzálvez, M., Martínez, T., Mediavilla, J. D., Fernández, C., Romero, J. A., González, A., Fajardo, R., Ramos, E., Aramburu, O., Rivera, F. J., Arias, J. L., Beltrán, J., Melguizo, I., Mateos, P. C., Mendoza, M. E., Romero, S. P., Motero, J., Guevara, J. A., Sánchez, H., Espino, A., Varela, J. M., Lobon, J. A., Jiménez, B., Arizón, J. M., Mora, J., Piñero, I., Gaitán, D., Fernández, D., Carmona, J. R., Garrido, A. M., Gómez, J. J., Costo, A., Alfredo, O., Marcos, G., Porras, Y., Hernández, J., Morales, J., Pérez, J. C., Suárez, M. M., Jiménez, P., and Martínez, F. J.

14. Adiponectin: An emerging cardiovascular risk factor. The REFERENCE study,Adiponectina, un factor de riesgo cardiovascular emergente. Estudio REFERENCE

Author

Barrios Alonso, V., Gómez-Huelgas, R., Rodríguez, R., Pablos-Velasco, P., Madruga, F., Velasco, E., Giménez, R., Rubio, J. M., López, J. A., Toril, J., Ordóñez, A., Yoldi, A., Montagud, J. B., Pinar, J., Fernández, M. L., Gómez, R., Sánchez, A., Martín, J. A., Mateos, L., Díaz, J. A., Suárez, M. A., Saban, J., Arroyo, R., López, J., Fontanals, C., López, A., Marín, R., Chacón, A., Carretero, J. F., Hernández, C., Pérez, L., Villar, M. R., Villar, J. R., Gorgojo, J. J., Barroso, E., Álvarez, P., Campillo, M., Camafort, M., Mazzanti, G., Garre, J., Morales, C., Conde, F. J., Gómez, P., Fernández, F., Suárez, S., Villarroel, M. T., Salgado, F. M., Egido, J., Enjuto, J., Gargallo, M. A., García, J. A., Azcona, L. M., Zamorano, J. L., Candel, I., Serra, V., García, A. M., Luis, D., Romero, E., Guerra, J. M., Gómez, F. J., Fuertes, J., Daniel, C., Gunther, S. J., Bellido, D., Yañez, J. C., Soto, F., Rigueiro, P., García, J. M., Díaz, J. L., Sotres, G., Rondan, J. J., Aziz, A., Barriales, V., Asensio, F., Richard, J. M., García, S., Rodrigo, A., Pérez, J., Ruiz, P., Angel, J., Gascueña, R., Ortiz, R., Rayo, M., Martínez, E., González, O., Ortiz, A., Gómez, L. F., Donnay, S., Melehi, D., Horcajo, P., García, F., Gómez, J., Calderón, A., Fernández, M. C., Pujadas, R., Rafael, J., Alfani, O., Virgos, G., Elsaheb, M., Recio, J., Montull, S., Abardia, X., Sucunza, N., Borrallo, R. M., Palos, M. A., Fernández, L. A., Arribas, J. M., Quintas, L., Camacho, I., Montes, P. M., Novales, J. A., Catalán, J. I., Arteaga, R., Ezcurdia, J., Moreno, C., Morillas, M., García, H., Ribas, M., Ortiz, J., Segura, I., Soler, J., Ripoll, T., Fosch, J., Moreno, R., Domenech, M., Antonio, M. T., Viguera, J., Paytubi, C., Blanch, P., Cuatrecasas, G., Gómez, J. M., Laguna, A., Mayos, J., Lapuebla, M. C., Morales, A., Silva, C., Taberna, S., Cordero, A., Pérez, S., Madariaga, I., Elejalde, J. I., Ancin, R., Tiberio, G., Gracia, M. L., Berdun, M. A., García, A., Gayán, R., Sanz, A., Férriz, P., Piedecausa, M. M., Toral, A., Hernández, E., Amancio Carnero, Arribas, J., Hernández, A., García, B., Gonzálvez, M., Martínez, T., Mediavilla, J. D., Fernández, C., Romero, J. A., González, A., Fajardo, R., Ramos, E., Aramburu, O., Rivera, F. J., Arias, J. L., Beltrán, J., Melguizo, I., Mateos, P. C., Mendoza, M. E., Romero, S. P., Motero, J., Guevara, J. A., Sánchez, H., Espino, A., Varela, J. M., Lobon, J. A., Jiménez, B., Arizón, J. M., Mora, J., Piñero, I., Gaitán, D., Fernández, D., Carmona, J. R., Garrido, A. M., Gómez, J. J., Costo, A., Alfredo, O., Marcos, G., Porras, Y., Hernández, J., Morales, J., Pérez, J. C., Suárez, M. M., Jiménez, P., and Martínez, F. J.

16. Prospective application of pre-defined intravascular ultrasound criteria for assessment of intermediate left main coronary artery lesions results from the multicenter LITRO study.

Author

de la Torre Hernandez JM, Hernández Hernandez F, Alfonso F, Rumoroso JR, Lopez-Palop R, Sadaba M, Carrillo P, Rondan J, Lozano I, Ruiz Nodar JM, Baz JA, Fernandez Nofrerias E, Pajin F, Garcia Camarero T, Gutierrez H, LITRO Study Group (Spanish Working Group on Interventional Cardiology), de la Torre Hernandez, Jose M, Hernández Hernandez, Felipe, Alfonso, Fernando, and Rumoroso, Jose R

Abstract

Objectives: This study is a prospective validation of 6 mm(2) as a minimum lumen area (MLA) cutoff value for revascularization of left main coronary artery (LMCA) lesions. Background: Lesions involving the LMCA are prognostically relevant. Angiography has important limitations in the evaluation of LMCA lesions with intermediate severity. An MLA of 6 mm(2) assessed by intravascular ultrasound has been proposed as a cutoff value to determine lesion severity, but there are no large studies evaluating the prospective application and safety of this approach. Methods: We have designed a multicenter, prospective study. Consecutive patients with intermediate lesions in unprotected LMCA were evaluated with intravascular ultrasound. An MLA <6 mm(2) was used as criterion for revascularization. Results: A total of 354 patients were included in 22 centers. LMCA revascularization was performed in 90.5% (152 of 168) of patients with an MLA <6 mm(2) and was deferred in 96% (179 of 186) of patients with an MLA of 6 mm(2) or more. A large scatter was observed between both groups regarding angiographic parameters. In a 2-year follow-up period, cardiac death-free survival was 97.7% in the deferred group versus 94.5% in the revascularized group (p = 0.5), and event-free survival was 87.3% versus 80.6%, respectively (p = 0.3). In the 2-year period, only 8 (4.4%) patients in the deferred group required subsequent LMCA revascularization, none with an infarction. Conclusions: Angiographic measurements are not reliable in the assessment of intermediate LMCA lesions. An MLA of 6 mm(2) or more is a safe value for deferring revascularization of the LMCA, given the application of the clinical and angiographic inclusion criteria used in this study. [ABSTRACT FROM AUTHOR]

Published
2011
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21. First-in-Man Evaluation of a Sirolimus-Eluting Stent With Abluminal Fluoropolymeric/Triflusal Coating With Ultrathin Struts by OCT at 9 Months' Follow-Up: The PROMETHEUS Study.

Author

de la Torre Hernandez JM, Otaegui I, Subinas A, Gomez-Menchero A, Moreno R, Rondan J, Muñoz-Garcia E, Sainz-Laso F, Garcia Del Blanco B, Rumoroso JR, Diaz JF, Berenguer A, Gomez-Lara J, and Zueco J

Subjects
Coronary Vessels diagnostic imaging, Coronary Vessels surgery, Humans, Neointima, Prospective Studies, Salicylates, Sirolimus adverse effects, Stents, Tomography, Optical Coherence, Treatment Outcome, Drug-Eluting Stents, Percutaneous Coronary Intervention adverse effects
Abstract

Objectives: We sought to investigate stent healing and neointimal hyperplasia with ihtDEStiny drug-eluting stent (DES) by optical coherence tomography (OCT) examination conducted 9 months after implantation., Background: The currently used DES present certain features that have been linked separately to their better performance in terms of efficacy and safety., Methods: First-in-man, prospective and multicenter study including patients treated with ihtDEStiny stent undergoing OCT examination at 9 months follow up. The ihtDEStiny stent is a sirolimus eluting stent with an oval shape ultrathin struts (68 μm) and an abluminal coating of a fluoropolymer containing the antiplatelet agent triflusal. Primary endpoint was the percentage of obstruction of the in-stent volume by the neointima., Results: In 58 patients (63 lesions) in-stent late lumen loss was 0.11 ± 0.23 mm (95% CI 0.05-0.16) with only in 6% of stents being > 0.5 mm and in-segment binary stenosis was 1.6%. In OCT mean neointima volume obstruction was 10.5 ± 6.9% with a mean neointima thickness of 110.9 ± 89.8 μm. The proportion of uncovered struts was 2.5%, malapposed struts 1.1% and malapposed/uncovered struts 0.7% and no subclinical thrombi detected. Mean incomplete stent apposition area was 0.1 ± 0.1 mm 2 . At 12 months target lesion revascularization rate was 3% and no stent thrombosis was reported., Conclusions: In this study the ihtDEStiny stent has shown a very low degree of neointimal proliferation associated with a low rate of uncovered/malapposed struts and total absence of subclinical thrombi at 9 months follow up., Competing Interests: Declaration of competing interest Jose M. de la Torre Hernández Receipt of grants/research support: Abbott Medical; Amgen. Receipt of honoraria or consultation fees: Boston Scientific; Medtronic; Biotronik; Astra Zeneca; Daiichi-Sankyo; BMS. This work has not been published previously and it is not under consideration for publication elsewhere. The manuscript has been approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2021
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34. Stent Choice in Very Large Left Main Lesions in 3 Patients.

Author

Lozano I, Rondan J, Vegas JM, and Segovia E

Subjects
Aged, 80 and over, Coronary Angiography, Coronary Stenosis diagnosis, Coronary Vessels diagnostic imaging, Female, Humans, Male, Middle Aged, Prosthesis Design, Coronary Stenosis surgery, Coronary Vessels surgery, Percutaneous Coronary Intervention methods, Stents
Abstract

Interventionalists encounter widely different coronary anatomies during left main coronary artery stenting. Optimal percutaneous coronary intervention in left main disease necessitates stents that achieve adequate apposition and adapt to frequently disparate diameters in the same lesion, without the need for overexpansion. Until recently, stent designs have hampered the treatment of very large lesions in left main arteries. Postdilation of the stents beyond their recommended diameters can cause restenosis, thrombosis, or arterial dissection. We report successful angiographic outcomes after our deployment of different stents in 3 patients, present our rationale for choosing each stent, and discuss considerations that influence the percutaneous treatment of severe left main disease.

Published
2017
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38. The dilemma of identification of the culprit lesion in multivessel disease in patients with complex collateral circulation.

Author

Lozano I, Rondan J, Vegas JM, and Segovia E

Subjects
Aged, Clinical Decision-Making, Humans, Male, Severity of Illness Index, Treatment Outcome, Angioplasty, Balloon adverse effects, Angioplasty, Balloon instrumentation, Angioplasty, Balloon methods, Collateral Circulation, Coronary Angiography methods, Coronary Vessels diagnostic imaging, Coronary Vessels pathology, Non-ST Elevated Myocardial Infarction diagnosis, Non-ST Elevated Myocardial Infarction physiopathology, Non-ST Elevated Myocardial Infarction surgery
Published
2016
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40. Usefulness of the catheter extension in combination with the fractional flow reserve in coronary grafts.

Author

Lozano I, Rondan J, Vegas JM, and Segovia E

Subjects
Aged, Angina, Unstable diagnostic imaging, Angina, Unstable physiopathology, Blood Flow Velocity physiology, Humans, Male, Percutaneous Coronary Intervention methods, Transplants transplantation, Angina, Unstable surgery, Cardiac Catheters, Fractional Flow Reserve, Myocardial physiology, Percutaneous Coronary Intervention instrumentation, Transplants physiology
Published
2016
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44. Escalating Loading Dose Regimens of Ticagrelor in Primary Percutaneous Intervention: A Second Opportunity for IIb/IIIa Inhibitors?

Author

Lozano I, Rondan J, Vegas JM, and Segovia E

Subjects
Female, Humans, Male, Adenosine analogs & derivatives, Blood Platelets drug effects, Myocardial Infarction therapy, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors pharmacokinetics, Purinergic P2Y Receptor Antagonists administration & dosage, Purinergic P2Y Receptor Antagonists pharmacokinetics
Published
2016
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45. Long-term antiplatelet therapy with the polypill after stenting: More information is necessary.

Author

Lozano I, Vega B, Sanchez LI, Rondan J, Vegas JM, and Segovia E

Subjects
Aged, Coronary Thrombosis etiology, Coronary Thrombosis prevention & control, Drug Administration Schedule, Drug Combinations, Humans, Male, Aspirin administration & dosage, Coronary Thrombosis diagnostic imaging, Platelet Aggregation Inhibitors administration & dosage, Ramipril administration & dosage, Simvastatin administration & dosage, Stents adverse effects
Published
2016
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46. Microvascular Function in Ischemic Heart Disease: There May Be Room for Improvement.

Author

Lozano I, Rondan J, Vegas JM, and Segovia E

Subjects
Female, Humans, Male, Coronary Artery Disease epidemiology, Coronary Artery Disease physiopathology, Coronary Circulation, Coronary Vessels physiopathology, Microcirculation, Microvascular Angina epidemiology, Microvascular Angina physiopathology, Microvessels physiopathology, Myocardial Infarction therapy, Myocardium pathology, Percutaneous Coronary Intervention
Published
2016
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