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315 results on '"Roncalli J"'

1. Comparison of in-hospital outcomes and long-term survival for valve-in-valve transcatheter aortic valve replacement versus the benchmark native valve transcatheter aortic valve replacement procedure

Author

Matta, A., primary, Levai, L., additional, Roncalli, J., additional, Meyer, E., additional, Bouisset, F., additional, Nader, V., additional, Blanco, S., additional, Campelo-Parada, F., additional, Carrié, D., additional, and Lhermusier, T., additional

Published
2024
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5. Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of the MESAMI 1 pilot trial

Author

Guijarro, D., Lebrin, M., Lairez, O., Bourin, P., Piriou, N., Pozzo, J., Lande, G., Berry, M., Le Tourneau, T., Cussac, D., Sensebe, L., Gross, F., Lamirault, G., Huynh, A., Manrique, A., Ruidavet, J.B., Elbaz, M., Trochu, J.N., Parini, A., Kramer, S., Galinier, M., Lemarchand, P., and Roncalli, J.

Published
2016
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12. Quels schémas vaccinaux contre les infections respiratoires chez l’insuffisant cardiaque ?

Author

Girerd, N., primary, Chapet, N., additional, Roubille, C., additional, Roncalli, J., additional, Salvat, M., additional, Mouquet, F., additional, Lamblin, N., additional, Gueffet, J.-P., additional, Damy, T., additional, Galinier, M., additional, Tartiere, J.-M., additional, Janssen, C., additional, Berthelot, E., additional, Aguilhon, S., additional, Escamilla, R., additional, and Roubille, F., additional

Published
2022
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17. The benefit of genetic testing using next-generation sequencing in patients with dilated cardiomyopathies: A multicentric international study

Author

Massot, M., primary, Itier, R., additional, Rico Ramirez, Y., additional, Rollin, A., additional, Fournier, P., additional, Ramis Barcelo, M.F., additional, Fortuny, E., additional, Torres, L., additional, Pons, J., additional, Barde, L., additional, Deney, A., additional, Roncalli, J., additional, Heine, D., additional, Peral, V., additional, Galinier, M., additional, Ripoll, T., additional, and Maury, P., additional

Published
2022
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27. Poster session: Dobutamine stress echo

Author

Le Tourneau, T, Sportouch, C, Foucher, C, Delasalle, B, Rosso, J, Neuder, Y, Trochu, JN, Roncalli, J, Lemarchand, P, and Manrique, A

Published
2012

32. What is the best imaging technique to explore right ventricular function at the time of multimodality cardiovascular imaging?

Author

Cazalbou, S., primary, Chong Fah Shen, V., additional, Petermann, A., additional, Eyharts, D., additional, Fournier, P., additional, Cariou, E., additional, Lavie-Badie, Y., additional, Hennig, A., additional, Roncalli, J., additional, Rousseau, H., additional, Galinier, M., additional, Carrié, D., additional, Berry, I., additional, and Lairez, O., additional

Published
2019
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34. Interventional treatment in diabetics in the era of drug-eluting stents and compliance to the ESC guidelines: lessons learned from the Euro Heart Survey Programme

Author

Onuma Y., Kukreja N., Ramcharitar S., Hochadel M., Gitt A., Serruys P., Marco J., Vahanian A., Weidinger F., Wijns W., Zeymer U., Silber S., Seabra-Gomez R., Eberli F., Manini M., Bramley C., Laforest V., Taylor C., Huber K., Backer G. D., Sirakova V., Cerbak R., Thayssen P., Aziz O. A., Tammam K., Lehto S., Delahaye F., Kobulia B., Cokkinos D., Kremastinos D., Karlocai K., Shelley E., Behar S., Maggioni A., Grabauskiene V., Deckers J., Asmussen I., Stepinska J., Goncalves L., Fonseca C., Mareev V., Vasilijevic Z., Riecansky M. I., Kenda M. F., Lopez-Sendon J. L., Rosengren A., Buser P., Okay T., Sychov O., Schofield P., Gitt A. K., Tavazzi L., Gomes R. S., de la Iglesia J. M., Wallentin L., Kearney P., McGregor K., Simoons M. L., Squibb B. -M., Lilly E., Margaryan K., Khachatryan S., Doerler J., Stocker E. -M., Altenberger I. J., Heigert M., Pichler M., Christ S. G., Glogar H., Lang I., Ingerle S., De Wilde P., de Marneffe M., Vrolix B. M., Dens J., Lierde J. V., De Wagter G. X., Carlier G. M., Weyne G. A., Legrand K. V., Doneux P., Gach O., Davin L., Mievis L. E., Massart P. -E., Holvoet N. G., Giunio L., Glavas D., Vukovic I., Markovic B., Duplancic D., Runjic F., Galic S. E., Mirat J., Kala P., Semenka J., Hlinomaz O., Petrikovits E., Widimsky B. P., Tousek P., Varvarovsky P. I., Cappelen H., Helqvist O. S., Kelbaek H., Jorgensen E., Engstrom T., Saunamaki K., Kastrup J., Clemmensen P., Hansen H., Al Abbadi M., Razek H. A., Aboul el Nasr G., Ragi H., Ibrihim B., Zarif B., el Banhawy N., Sorour K., Meguid M. A., Mahrous A., Al Khashab K. A., Ahmed Abd Elmoniem F., El Emry M., El Naggar A., Saad B. A., Laanmets P., Voitk J., Lutter P., Jarvekulg S., Jalakas M., Reinmets J., Marandi T., Peeba M., Serka T., Syvannne M., Kaihovirta E., Korpilahti H. K., Vaittinen M. -A., Bassand J. -P., Espinosa D. P., Cottin B. Y., Lhuillier I., Buffet P., Lorgis L., Machecourt D. J., Bertrand B., Serrano D., Bonnet G. J. -L., Steg M. P. G., Juliard J. -M., Farnoud R., Delarche P. N., Marco P. J., Petit F., Farah B., Carrie D., Galinier M., Puel J., Cahuzac J., Roncalli J., Tauzin S., Elbaz M., Schachinger V., Gitt F. A., am Rhein Ralf Zahn L., Fraiture B., Haetinger S., Klepzig N. H., Girth E., Hauber A., Firschke O. C., Widmaier J., Hofbauer F., Huttl S., Sechtem P. U., Parade U., Linnartz S. G., Andrianidis S., Tsiavou N., Papaioannou G., Deliargyris E., Attikis M., Alexopoulos D., Davlouros P., Tsikaderis D., Dardas P., Mezilis N., Istvan E., Zoltan B., Turgeman Y., Khaled S., Feldman A., Jafari J., Manevich I., Cafri C., Ilia R., Abu-Ful A., Yaroslavslev S., Wainstain J. M., Rosenchtein G., Sheva B., Krakover R., Yakov B., Halon D., Gruberg L., Markiewicz W., Grenadier E., Boulos M., Roguin A., Kerner A., Amikam S., Ben-Tzvi M., Rezmovitz J., Mosseri H. M., Lotan H., Varshizky B., Nassar H., Daninberg H., Rot D., Vais T., Benhorin J., Keren A., Medina A., Huri Z., Brandis J. S., Schoenmann G., Kornowski N. R., Assali A., Fuch S., Hasdai D., Brosh D., Sela O., Teplitski I., Tikva P., Eisenberg O., Banai S., Finkelstein A., Hasin Y., Aboud M., Nahir M., Qarwani D., Diab G., Meloni L., Lai G., Cadeddu M., Pirisi R., Bonechi F., Nassi F., Nieri M., Taiti A., Naldoni A., Calabro F., Achilli F., Maggiolini S., Piatti L., Tiberti G., Addamiano P., Berti S., Ravani M., Palmieri C., Trianni G., Cardullo S., Cioppa A., Rubino P., Ambrosini V., Salemme L., Sorropago G., Tesorio T., Geraci G., Scalise F., Mazzeti S., Auguadro C., Esposito G., Canali G., Caccia M. E., Ruggieri C., Benedetta B., de Cesare N., De Benedictis M., Coco T., Manzotti S., Fraz O. S., Marraccini P., Danesi A., Ricci R., Ferraironi A., Olivieri E., Chiera A., Garducci S., Grasseli D., McFadden E., Cahill N., Quinn M., Crean P., Caroll E., Foley D., O'Connor S., O'Hanlon R., Lynch B., O'Donnell S., Roy J., O'Brien D., Krastina A., Erglis A., Lawand S., Dorniak W., Klaudel J., Pawlowski K., Trenkner W., Janion M., Sadowski M., Janion-Sadowska A., Skorupa I., Bystryk L., Kern A., Janiak B., Szelemej R., Ruzyllo W., Witkowski A., Deptuch T., Maczynska-Mazuruk R., Budaj A., Cegieska K. L., Opolski G., Wilczyska J., Roik M., Kochman J., Martins D., Goncalves I. M. F. J., Pereira H., Faria H., Calisto J., Matos V., Leitao-Marques A., Costa M., Oliveira H., Mota P., Santos W., Brandao V., Caires F. G., Silva B., Teles F. R. C., Almeida M., Goncalves P., Raposo L., Mourao L., Bernardes L., Pedro P. G., Ferreira R., Conduto R., Quininha J., Patricio L., Cacela D., Goncalves J. M., de Sousa L., Adao M., Carvalho L. H. C., Romeira H., Sousa J. P., Garcia J. M. M., Silva J. C., Magalhaes D., Santos P. R., Mendes S. P. G., Pipa J., Nunes L., Ferreira P., Vinereanu D., Udroiu C., Florescu N., Parvu O., Stoicescu C., Dorobantu M., Balanescu S. M., Niculescu R., Calmac L., Marinescu M., Olinic B. D., Ober M., Homorodean C., Budurea C., Hij A., Anton F., Cluj-Napoca, Ortan F., Suciu C., Ursu M., Baba C., Targu-Mures, Dragulescu S. I., Petrescu L., Slovenski M., Gavrilescu D., Dina C., Mut B., Babic R., Colic M., Topic D., Vilarrasa J. B., Pont M. P., Martorell R. M., Rohlfs I., Moreno R. M., Irurita M., Irurita J., de Gran Canaria L. P., Cervantes C. E., Galvan T., Navarro J., Franco D., Rodriguez I. S., Ramirez V. H., Fernandes-Aviles F., Revilla A., Masson N., Dupertuis V., Kachboura S., Iyisoy A., Erol M. K., Ongen Z., Babalik E., Oskan M., Ozdemir N., Oto A., Aytemir K., Yavuz B., Sahin M., Durna K., Aytekin V., Demiroglu C., Gulbaran M., Aytekin S., Catakoglu A. B., Ozme B., Gemici G., Feray H., Schofield P. M., Kahn S., Clarke S., Millington H., Di Mario C., Dempster D., Henderson R. A., Burton J., Falcon-Lang D., Cardiology, Onuma, Y., Kukreja, N., Ramcharitar, S., Hochadel, M., Gitt, A., Serruys, P., Marco, J., Vahanian, A., Weidinger, F., Wijns, W., Zeymer, U., Silber, S., Seabra-Gomez, R., Eberli, F., Manini, M., Bramley, C., Laforest, V., Taylor, C., Huber, K., Backer, G. D., Sirakova, V., Cerbak, R., Thayssen, P., Aziz, O. A., Tammam, K., Lehto, S., Delahaye, F., Kobulia, B., Cokkinos, D., Kremastinos, D., Karlocai, K., Shelley, E., Behar, S., Maggioni, A., Grabauskiene, V., Deckers, J., Asmussen, I., Stepinska, J., Goncalves, L., Fonseca, C., Mareev, V., Vasilijevic, Z., Riecansky, M. I., Kenda, M. F., Lopez-Sendon, J. L., Rosengren, A., Buser, P., Okay, T., Sychov, O., Schofield, P., Gitt, A. K., Tavazzi, L., Gomes, R. S., de la Iglesia, J. M., Wallentin, L., Kearney, P., Mcgregor, K., Simoons, M. L., Squibb, B. -M., Lilly, E., Margaryan, K., Khachatryan, S., Doerler, J., Stocker, E. -M., Altenberger, I. J., Heigert, M., Pichler, M., Christ, S. G., Glogar, H., Lang, I., Ingerle, S., De Wilde, P., de Marneffe, M., Vrolix, B. M., Dens, J., Lierde, J. V., De Wagter, G. X., Carlier, G. M., Weyne, G. A., Legrand, K. V., Doneux, P., Gach, O., Davin, L., Mievis, L. E., Massart, P. -E., Holvoet, N. G., Giunio, L., Glavas, D., Vukovic, I., Markovic, B., Duplancic, D., Runjic, F., Galic, S. E., Mirat, J., Kala, P., Semenka, J., Hlinomaz, O., Petrikovits, E., Widimsky, B. P., Tousek, P., Varvarovsky, P. I., Cappelen, H., Helqvist, O. S., Kelbaek, H., Jorgensen, E., Engstrom, T., Saunamaki, K., Kastrup, J., Clemmensen, P., Hansen, H., Al Abbadi, M., Razek, H. A., Aboul el Nasr, G., Ragi, H., Ibrihim, B., Zarif, B., el Banhawy, N., Sorour, K., Meguid, M. A., Mahrous, A., Al Khashab, K. A., Ahmed Abd Elmoniem, F., El Emry, M., El Naggar, A., Saad, B. A., Laanmets, P., Voitk, J., Lutter, P., Jarvekulg, S., Jalakas, M., Reinmets, J., Marandi, T., Peeba, M., Serka, T., Syvannne, M., Kaihovirta, E., Korpilahti, H. K., Vaittinen, M. -A., Bassand, J. -P., Espinosa, D. P., Cottin, B. Y., Lhuillier, I., Buffet, P., Lorgis, L., Machecourt, D. J., Bertrand, B., Serrano, D., Bonnet, G. J. -L., Steg, M. P. G., Juliard, J. -M., Farnoud, R., Delarche, P. N., Marco, P. J., Petit, F., Farah, B., Carrie, D., Galinier, M., Puel, J., Cahuzac, J., Roncalli, J., Tauzin, S., Elbaz, M., Schachinger, V., Gitt, F. A., am Rhein Ralf Zahn, L., Fraiture, B., Haetinger, S., Klepzig, N. H., Girth, E., Hauber, A., Firschke, O. C., Widmaier, J., Hofbauer, F., Huttl, S., Sechtem, P. U., Parade, U., Linnartz, S. G., Andrianidis, S., Tsiavou, N., Papaioannou, G., Deliargyris, E., Attikis, M., Alexopoulos, D., Davlouros, P., Tsikaderis, D., Dardas, P., Mezilis, N., Istvan, E., Zoltan, B., Turgeman, Y., Khaled, S., Feldman, A., Jafari, J., Manevich, I., Cafri, C., Ilia, R., Abu-Ful, A., Yaroslavslev, S., Wainstain, J. M., Rosenchtein, G., Sheva, B., Krakover, R., Yakov, B., Halon, D., Gruberg, L., Markiewicz, W., Grenadier, E., Boulos, M., Roguin, A., Kerner, A., Amikam, S., Ben-Tzvi, M., Rezmovitz, J., Mosseri, H. M., Lotan, H., Varshizky, B., Nassar, H., Daninberg, H., Rot, D., Vais, T., Benhorin, J., Keren, A., Medina, A., Huri, Z., Brandis, J. S., Schoenmann, G., Kornowski, N. R., Assali, A., Fuch, S., Hasdai, D., Brosh, D., Sela, O., Teplitski, I., Tikva, P., Eisenberg, O., Banai, S., Finkelstein, A., Hasin, Y., Aboud, M., Nahir, M., Qarwani, D., Diab, G., Meloni, L., Lai, G., Cadeddu, M., Pirisi, R., Bonechi, F., Nassi, F., Nieri, M., Taiti, A., Naldoni, A., Calabro, F., Achilli, F., Maggiolini, S., Piatti, L., Tiberti, G., Addamiano, P., Berti, S., Ravani, M., Palmieri, C., Trianni, G., Cardullo, S., Cioppa, A., Rubino, P., Ambrosini, V., Salemme, L., Sorropago, G., Tesorio, T., Geraci, G., Scalise, F., Mazzeti, S., Auguadro, C., Esposito, G., Canali, G., Caccia, M. E., Ruggieri, C., Benedetta, B., de Cesare, N., De Benedictis, M., Coco, T., Manzotti, S., Fraz, O. S., Marraccini, P., Danesi, A., Ricci, R., Ferraironi, A., Olivieri, E., Chiera, A., Garducci, S., Grasseli, D., Mcfadden, E., Cahill, N., Quinn, M., Crean, P., Caroll, E., Foley, D., O'Connor, S., O'Hanlon, R., Lynch, B., O'Donnell, S., Roy, J., O'Brien, D., Krastina, A., Erglis, A., Lawand, S., Dorniak, W., Klaudel, J., Pawlowski, K., Trenkner, W., Janion, M., Sadowski, M., Janion-Sadowska, A., Skorupa, I., Bystryk, L., Kern, A., Janiak, B., Szelemej, R., Ruzyllo, W., Witkowski, A., Deptuch, T., Maczynska-Mazuruk, R., Budaj, A., Cegieska, K. L., Opolski, G., Wilczyska, J., Roik, M., Kochman, J., Martins, D., Goncalves, I. M. F. J., Pereira, H., Faria, H., Calisto, J., Matos, V., Leitao-Marques, A., Costa, M., Oliveira, H., Mota, P., Santos, W., Brandao, V., Caires, F. G., Silva, B., Teles, F. R. C., Almeida, M., Goncalves, P., Raposo, L., Mourao, L., Bernardes, L., Pedro, P. G., Ferreira, R., Conduto, R., Quininha, J., Patricio, L., Cacela, D., Goncalves, J. M., de Sousa, L., Adao, M., Carvalho, L. H. C., Romeira, H., Sousa, J. P., Garcia, J. M. M., Silva, J. C., Magalhaes, D., Santos, P. R., Mendes, S. P. G., Pipa, J., Nunes, L., Ferreira, P., Vinereanu, D., Udroiu, C., Florescu, N., Parvu, O., Stoicescu, C., Dorobantu, M., Balanescu, S. M., Niculescu, R., Calmac, L., Marinescu, M., Olinic, B. D., Ober, M., Homorodean, C., Budurea, C., Hij, A., Anton, F., Cluj-Napoca, Ortan, F., Suciu, C., Ursu, M., Baba, C., Targu-Mures, Dragulescu, S. I., Petrescu, L., Slovenski, M., Gavrilescu, D., Dina, C., Mut, B., Babic, R., Colic, M., Topic, D., Vilarrasa, J. B., Pont, M. P., Martorell, R. M., Rohlfs, I., Moreno, R. M., Irurita, M., Irurita, J., de Gran Canaria, L. P., Cervantes, C. E., Galvan, T., Navarro, J., Franco, D., Rodriguez, I. S., Ramirez, V. H., Fernandes-Aviles, F., Revilla, A., Masson, N., Dupertuis, V., Kachboura, S., Iyisoy, A., Erol, M. K., Ongen, Z., Babalik, E., Oskan, M., Ozdemir, N., Oto, A., Aytemir, K., Yavuz, B., Sahin, M., Durna, K., Aytekin, V., Demiroglu, C., Gulbaran, M., Aytekin, S., Catakoglu, A. B., Ozme, B., Gemici, G., Feray, H., Schofield, P. M., Kahn, S., Clarke, S., Millington, H., Di Mario, C., Dempster, D., Henderson, R. A., Burton, J., and Falcon-Lang, D.

Subjects
Registrie, Male, medicine.medical_treatment, Angiotensin-Converting Enzyme Inhibitors, Comorbidity, Coronary Artery Disease, Severity of Illness Index, Cardiovascular Disease, Hospital Mortality, Registries, Angioplasty, Balloon, Coronary, Drug-Eluting Stents, Middle Aged, Clopidogrel, Europe, Treatment Outcome, Drug-eluting stent, Cardiovascular Diseases, Practice Guidelines as Topic, Female, Guideline Adherence, Inpatient, Cardiology and Cardiovascular Medicine, Human, medicine.drug, medicine.medical_specialty, Diabetic Angiopathie, Adrenergic beta-Antagonists, Diabetic, SDG 3 - Good Health and Well-being, Internal medicine, Diabetes mellitus, Angioplasty, medicine, Humans, Drug eluting stent, cardiovascular diseases, Risk factor, Aged, European Heart Survey, Inpatients, Clinical Audit, business.industry, Platelet Aggregation Inhibitor, Adrenergic beta-Antagonist, Angiotensin-Converting Enzyme Inhibitor, Guideline, medicine.disease, Surgery, Health Care Survey, Health Care Surveys, Conventional PCI, Hydroxymethylglutaryl-CoA Reductase Inhibitor, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Diabetic Angiopathies, Platelet Aggregation Inhibitors
Abstract

Aims: The objective of the study is to determine the demographics and the in-hospital outcome of diabetic and non-diabetic patients treated with percutaneous coronary interventions (PCI) in Europe, to report the type of equipment and technology used for PCI procedures in diabetics and to clarify whether the treatment of diabetic patients complies with current European Society of Cardiology (ESC) guidelines. Methods and results: A total of 14,458 patients treated with PCI were enrolled from 29 member countries of the ESC between June 2005 and January 2006. Data were collected on patient characteristics and treatment, using new Cardiology Audit and Registration Data standards. In total, 3,603 patients (24.9%) were diabetic. Diabetics were older, more often female and had a higher body mass index than non-diabetics. Diabetics had higher rates of hypercholesterolaemia and hypertension, while current smokers were more frequent in the non-diabetics. Diabetics also had significantly higher rates of previous cardiovascular events. Clopidogrel was administered only in 48.1% of diabetic patients before PCI, while IIb/IIIa inhibitors were 22.9% during PCI. At discharge, there was a major adjustment of treatment with increases in the use of Beta-blocker (80.4%), angiotensin converting enzyme inhibitor (ACEI, 71.3%) and statins (89.8%) compared with on admission (Beta-blocker 60.9%, ACEI 55.0%, statin 63.1%). Inhospital mortality was higher in diabetics (1.8% vs 1.2%) although the in-hospital MACCE rate was not significantly different (3.6% vs 3.0%, p=0.09). Conclusions: Diabetic patients treated with PCI were older with more comorbidity. According to ESC guideline, the under-usage of clopidogrel, GP IIb/IIIa inhibitors should be improved. PCI is now taken as a good opportunity to adjust the use of appropriate medication. © Europa Edition. All rights reserved.

Published
2009

35. Discovery and validation of a new biomarker for heart failure diagnostic

Author

Berry, M., primary, Galinier, M., additional, Delmas, C., additional, Fournier, P., additional, Desmoulin, F., additional, Turkieh, A., additional, Mischak, H., additional, Mullen, W., additional, Barutaut, M., additional, Eurlings, L., additional, Brunner La Rocca, H.P., additional, Butler, J., additional, Roncalli, J., additional, Evaristi, M.F., additional, Cohen-Solal, A., additional, Escamilla, R., additional, Ferrieres, J., additional, Koukoui, F., additional, Smih, F., additional, and Rouet, P., additional

Published
2018
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36. Prognosis impact of frailty assessed by the Edmonton Frail Scale in the setting of acute coronary syndrome in the elderly

Author

Blanco, S., primary, Ferrières, J., additional, Bongard, V., additional, Toulza, O., additional, Sebai, F., additional, Billet, S., additional, Biendel, C., additional, Lairez, O., additional, Lhermusier, T., additional, Boudou, N., additional, Campelo-Parada, F., additional, Roncalli, J., additional, Galinier, M., additional, Carrié, D., additional, Elbaz, M., additional, and Bouisset, F., additional

Published
2018
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38. Global position paper on cardiovascular regenerative medicine

Author

Fernández-Avilés, F. (Francisco), Sanz-Ruiz, R. (Ricardo), Climent, A.M. (Andreu M.), Badimon, L. (Lina), Bolli, R. (Roberto), Charron, D. (Dominique), Fuster, V. (Valentin), Janssens, S. (Stefan), Kastrup, J. (Jens), Kim, H.-S. (Hyo-Soo), Lüscher, T.F., Martin, J.F. (John F.), Menasche, P. (Philippe), Simari, P. (Patricio), Stone, G.W. (Gregg), Terzic, A. (Andre), Willerson, J.T. (James), Wu, J.C. (Joseph C.), Joseph, C.W. (C. Wu), Broughton, K. (Kathleen), DiFede, D.L. (Darcy L.), Dimmeler, S. (Stefanie), Madonna, R. (Rosalinda), Penn, M.S. (Marc S.), Sussman, M.A. (Mark A.), Sluijter, J.P.G., Woller, K.C. (Kai C.), Balkan, W. (Wayne), Chamuleau, S.A.J. (Steven), Fernández-Santos, M.E. (Maria Eugenia), Goliasch, G. (Georg), Gyöngyösi, M. (Mariann), Hare, J.M. (Joshua M.), Tompkins, B.A. (Bryon A.), Winkler, J. (Johannes), Bayés-Genis, A. (Antoni), Henry, T.D. (Timothy), Taylor, D.A. (Doris), Lerman, A. (Amir), Pelacho, B. (Beatriz), Prosper, F. (Felipe), Perin, E.C. (Emerson ), Pompilio, G. (Giulio), Gersh, B.J. (Bernard), Bartúnek, J. (Jozef), Duckers, E. (Eric), Ferdinandy, P. (Péter), Losordo, D.W. (Douglas W.), Čanchez, P.L. (Pedro L.), Sherman, W. (Warren), Wojakowski, W. (Wojtek), Zeiher, A.M. (Andreas), Roncalli, J. (Jérôme), Mathur, A. (Anthony), Crea, F. (Filippo), D'Amario, D. (Domenico), Povsic, T.J. (Thomas J.), Traverse, J.H. (Jay), Ylä-Herttuala, S. (Seppo), Fernández-Avilés, F. (Francisco), Sanz-Ruiz, R. (Ricardo), Climent, A.M. (Andreu M.), Badimon, L. (Lina), Bolli, R. (Roberto), Charron, D. (Dominique), Fuster, V. (Valentin), Janssens, S. (Stefan), Kastrup, J. (Jens), Kim, H.-S. (Hyo-Soo), Lüscher, T.F., Martin, J.F. (John F.), Menasche, P. (Philippe), Simari, P. (Patricio), Stone, G.W. (Gregg), Terzic, A. (Andre), Willerson, J.T. (James), Wu, J.C. (Joseph C.), Joseph, C.W. (C. Wu), Broughton, K. (Kathleen), DiFede, D.L. (Darcy L.), Dimmeler, S. (Stefanie), Madonna, R. (Rosalinda), Penn, M.S. (Marc S.), Sussman, M.A. (Mark A.), Sluijter, J.P.G., Woller, K.C. (Kai C.), Balkan, W. (Wayne), Chamuleau, S.A.J. (Steven), Fernández-Santos, M.E. (Maria Eugenia), Goliasch, G. (Georg), Gyöngyösi, M. (Mariann), Hare, J.M. (Joshua M.), Tompkins, B.A. (Bryon A.), Winkler, J. (Johannes), Bayés-Genis, A. (Antoni), Henry, T.D. (Timothy), Taylor, D.A. (Doris), Lerman, A. (Amir), Pelacho, B. (Beatriz), Prosper, F. (Felipe), Perin, E.C. (Emerson ), Pompilio, G. (Giulio), Gersh, B.J. (Bernard), Bartúnek, J. (Jozef), Duckers, E. (Eric), Ferdinandy, P. (Péter), Losordo, D.W. (Douglas W.), Čanchez, P.L. (Pedro L.), Sherman, W. (Warren), Wojakowski, W. (Wojtek), Zeiher, A.M. (Andreas), Roncalli, J. (Jérôme), Mathur, A. (Anthony), Crea, F. (Filippo), D'Amario, D. (Domenico), Povsic, T.J. (Thomas J.), Traverse, J.H. (Jay), and Ylä-Herttuala, S. (Seppo)

Published
2017
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39. Global position paper on cardiovascular regenerative medicine

Author

Fernandez-Aviles, F, Sanz-Ruiz, R, Climent, AM, Badimon, L, Bolli, R, Charron, D, Fuster, V, Janssens, S, Kastrup, J, Kim, HS, Luscher, TF, Martin, JF, Menasche, P, Simari, RD, Stone, GW, Terzic, A, Willerson, JT, Wu, JC, Broughton, K, DiFede, DL, Dimmeler, S, Madonna, R, Penn, MS, Sussman, MA, Sluijter, JPG, Wollert, KC, Balkan, W, Chamuleau, S, Fernandez-Santos, ME, Goliasch, G, Gyongyosi, M, Hare, JM, Tompkins, BA, Winkler, J, Bayes-Genis, A, Henry, TD, Taylor, DA, Lerman, A, Pelacho, B, Prosper, F, Perin, EC, Pompilio, G, Gersh, B, Bartunek, J, Duckers, Eric, Ferdinandy, P, Losordo, DW, Sanchez, PL, Sherman, W, Wojakowski, W, Zeiher, A, Roncalli, J, Mathur, A, Crea, F, D'Amario, D, Povsic, TJ, Traverse, J, Yla-Herttuala, S, Fernandez-Aviles, F, Sanz-Ruiz, R, Climent, AM, Badimon, L, Bolli, R, Charron, D, Fuster, V, Janssens, S, Kastrup, J, Kim, HS, Luscher, TF, Martin, JF, Menasche, P, Simari, RD, Stone, GW, Terzic, A, Willerson, JT, Wu, JC, Broughton, K, DiFede, DL, Dimmeler, S, Madonna, R, Penn, MS, Sussman, MA, Sluijter, JPG, Wollert, KC, Balkan, W, Chamuleau, S, Fernandez-Santos, ME, Goliasch, G, Gyongyosi, M, Hare, JM, Tompkins, BA, Winkler, J, Bayes-Genis, A, Henry, TD, Taylor, DA, Lerman, A, Pelacho, B, Prosper, F, Perin, EC, Pompilio, G, Gersh, B, Bartunek, J, Duckers, Eric, Ferdinandy, P, Losordo, DW, Sanchez, PL, Sherman, W, Wojakowski, W, Zeiher, A, Roncalli, J, Mathur, A, Crea, F, D'Amario, D, Povsic, TJ, Traverse, J, and Yla-Herttuala, S

Published
2017

40. P4697Prognosis impact of frailty assessed by the Edmonton Frail Scale in the setting of acute coronary syndrome in the elderly

Author

Bouisset, F., primary, Blanco, S., additional, Bongard, V., additional, Sebai, F., additional, Billet, S., additional, Biendel, C., additional, Lairez, O., additional, Lhermusier, T., additional, Boudou, N., additional, Campelo-Parada, F., additional, Roncalli, J., additional, Galinier, M., additional, Elbaz, M., additional, Carrie, D., additional, and Ferrieres, J., additional

Published
2017
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41. Challenges between clinical sites and cell therapy facilities in the excellent trial (expanded cell endocardiac transplantation), a phase I/IIb clinical trial

Author

Criquet, A., primary, Mai, E., additional, Saucourt, C., additional, Vogt, S., additional, Giganti, P., additional, Baron, S., additional, Roncalli, J., additional, Lairez, O., additional, Lagente, C., additional, Lebrin, M., additional, Ioannides, K., additional, Manrique, A., additional, Saloux, E., additional, Leroux, L., additional, Goin, V., additional, Roubille, F., additional, Lefèvre, T., additional, Hovasse, T., additional, Vanzetto, G., additional, Derenne, S., additional, Tertrais, K., additional, Newby, D., additional, Cruden, N., additional, Mills, N., additional, Greenwood, J., additional, Wheatcroft, S., additional, Dickinson, A., additional, Black, A., additional, and Henon, P., additional

Published
2017
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42. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data

Author

Gyongyosi, M., Wojakowski, W., Lemarchand, P., Lunde, K., Tendera, M., Bartunek, J., Marban, E., Assmus, B., Henry, T.D., Traverse, J.H., Moye, L.A., Surder, D., Corti, R., Huikuri, H., Miettinen, J., Wohrle, J., Obradovic, S., Roncalli, J., Malliaras, K., Pokushalov, E., Romanov, A., Kastrup, J., Bergmann, M.W., Atsma, D.E., Diederichsen, A., Edes, I., Benedek, I., Benedek, T., Pejkov, H., Nyolczas, N., Pavo, N., Bergler-Klein, J., Pavo, I.J., Sylven, C., Berti, S., Navarese, E.P., Maurer, G., ACCRUE Investigators, Department of Cardiology [Vienna], Medizinische Universität Wien = Medical University of Vienna, Third Division of Cardiology, Medical University of Silesia, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Department of Cardiology, Rikshospitalet-Oslo University Hospital [Oslo], department organization Studies, Boston College (BC), Cedars-Sinai Medical Center, Department of Medicine III, Goethe-Universität Frankfurt am Main, Dpt of Neurology [Minneapolis], University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, Minneapolis Heart Institute, University of Minnesota System-University of Minnesota System-Abbott Northwestern Hospital, Coordinating Center for Clinical Trials, The University of Texas Health Science Center at Houston (UTHealth), Cardiocentro Ticino [Lugano], Universität Zürich [Zürich] = University of Zurich (UZH), Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Medical Research Center Oulu, University of Oulu, Cardiology Department [Ulm], Universität Ulm - Ulm University [Ulm, Allemagne], Clinic of Emergency Medicine, Military Medical Academy [Serbia], Service de cardiologie [Toulouse], Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], State Research Institute of Circulation Pathology, Department of Drug Design and Pharmacology [Copenhagen] (ILF), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Asklepios Klinik St. Georg, Cardiology Department [Leiden], Leiden University Medical Center (LUMC), Cardiology Department [Odense], Odense University Hospital (OUH), Cardiology Department [Debrecen], University of Debrecen, Cardiology Department [Târgu Mureș], University of Medicine and Pharmacy of Târgu Mureș, University Clinic for Cardiology, Medical Centre [Budapest], Hungarian Defense Forces -Ministry of Defence [Budapest], Karolinska Institutet [Stockholm], Invasive Cardiology [Pisa], National Research Council Institute of Clinical Physiology (CNR-IFC), Internal Medicine [Düsseldorf], Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]-Division of Cardiology, Pulmonology and Vascular Medicine, TIME and LateTIME were supported by a grant from the National Heart, Lung, and Blood Institute under the cooperative agreement 5 UM1 HL087318-01. Part of the study was supported by European Union structural funds (Innovative Economy Operational Program POIG.01.01.02-00-109/09-00) to Dr Wojakowski., Medical University of Silesia (SUM), Unité de recherche de l'institut du thorax (ITX-lab), Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Lemarchand, Patricia, University of Zurich, Gyongyosi, M, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Minnesota [Twin Cities], University of Zürich [Zürich] (UZH), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Odense University Hospital, and Heinrich-Heine-Universität Düsseldorf [Düsseldorf]-Division of Cardiology, Pulmonology and Vascular Medicine

Subjects
Male, Time Factors, MESH: Chi-Square Distribution, Databases, Factual, Physiology, analysis, MESH: Myocardial Contraction, Myocardial Infarction, heart failure, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, MESH: Stroke Volume, Ventricular Function, Left, MESH: Ventricular Function, Left, MESH: Proportional Hazards Models, 0302 clinical medicine, Recurrence, Risk Factors, MESH: Risk Factors, Myocardial infarction, Prospective Studies, MESH: Bone Marrow Transplantation, Stroke, Bone Marrow Transplantation, Randomized Controlled Trials as Topic, MESH: Treatment Outcome, MESH: Aged, 0303 health sciences, Ejection fraction, MESH: Middle Aged, Ventricular Remodeling, Hazard ratio, MESH: Regeneration, Stroke volume, Middle Aged, MESH: Recovery of Function, 3. Good health, MESH: Myocardial Infarction, Treatment Outcome, Cardiology, Female, MESH: Cerebrovascular Disorders, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, MESH: Myocardium, 610 Medicine & health, MESH: Ventricular Remodeling, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, meta, Disease-Free Survival, 11171 Cardiocentro Ticino, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, stem cells, Internal medicine, medicine, Humans, Regeneration, cardiovascular diseases, Ventricular remodeling, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, outcome assessment, End-systolic volume, MESH: Kaplan-Meier Estimate, 030304 developmental biology, Aged, Proportional Hazards Models, Chi-Square Distribution, MESH: Humans, business.industry, Myocardium, MESH: Time Factors, Stroke Volume, Recovery of Function, 1314 Physiology, medicine.disease, Myocardial Contraction, MESH: Databases, Factual, anterior wall myocardial infarction, MESH: Male, MESH: Prospective Studies, MESH: Recurrence, meta-analysis, Cerebrovascular Disorders, MESH: Randomized Controlled Trials as Topic, Heart failure, MESH: Disease-Free Survival, business, MESH: Female
Abstract

Rationale : The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. Objective : We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI), including individual patient data from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE-TIME; n=1252). Methods and Results : The primary end point was freedom from combined major adverse cardiac and cerebrovascular events (including all-cause death, AMI recurrance, stroke, and target vessel revascularization). The secondary end point was freedom from hard clinical end points (death, AMI recurrence, or stroke), assessed with random-effects meta-analyses and Cox regressions for interactions. Secondary efficacy end points included changes in end-diastolic volume, end-systolic volume, and ejection fraction, analyzed with random-effects meta-analyses and ANCOVA. We reported weighted mean differences between cell therapy and control groups. No effect of cell therapy on major adverse cardiac and cerebrovascular events (14.0% versus 16.3%; hazard ratio, 0.86; 95% confidence interval, 0.63–1.18) or death (1.4% versus 2.1%) or death/AMI recurrence/stroke (2.9% versus 4.7%) was identified in comparison with controls. No changes in ejection fraction (mean difference: 0.96%; 95% confidence interval, −0.2 to 2.1), end-diastolic volume, or systolic volume were observed compared with controls. These results were not influenced by anterior AMI location, reduced baseline ejection fraction, or the use of MRI for assessing left ventricular parameters. Conclusions : This meta-analysis of individual patient data from randomized trials in patients with recent AMI revealed that intracoronary cell therapy provided no benefit, in terms of clinical events or changes in left ventricular function. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01098591.

Published
2015

43. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data

Author

Gyongyosi, M, Wojakowski, W, Lemarchand, P, Lunde, K, Tendera, M, Bartunek, J, Marban, E, Assmus, B, Henry, T D, Traverse, J H, Moye, L A, Surder, D, Corti, R, Huikuri, H, Miettinen, J, Wohrle, J, Obradovic, S, Roncalli, J, Malliaras, K, Pokushalov, E, Romanov, A, Kastrup, J, Bergmann, M W, Atsma, D E, Diederichsen, A, Edes, I, Benedek, I, Benedek, T, Pejkov, H, Nyolczas, N, Pavo, N, Bergler-Klein, J, Pavo, I J, Sylven, C, Berti, S, Navarese, E P, Maurer, G, Gyongyosi, M, Wojakowski, W, Lemarchand, P, Lunde, K, Tendera, M, Bartunek, J, Marban, E, Assmus, B, Henry, T D, Traverse, J H, Moye, L A, Surder, D, Corti, R, Huikuri, H, Miettinen, J, Wohrle, J, Obradovic, S, Roncalli, J, Malliaras, K, Pokushalov, E, Romanov, A, Kastrup, J, Bergmann, M W, Atsma, D E, Diederichsen, A, Edes, I, Benedek, I, Benedek, T, Pejkov, H, Nyolczas, N, Pavo, N, Bergler-Klein, J, Pavo, I J, Sylven, C, Berti, S, Navarese, E P, and Maurer, G

Abstract

RATIONALE: The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. OBJECTIVE: We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI), including individual patient data from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE-TIME; n=1252). METHODS AND RESULTS: The primary end point was freedom from combined major adverse cardiac and cerebrovascular events (including all-cause death, AMI recurrance, stroke, and target vessel revascularization). The secondary end point was freedom from hard clinical end points (death, AMI recurrence, or stroke), assessed with random-effects meta-analyses and Cox regressions for interactions. Secondary efficacy end points included changes in end-diastolic volume, end-systolic volume, and ejection fraction, analyzed with random-effects meta-analyses and ANCOVA. We reported weighted mean differences between cell therapy and control groups. No effect of cell therapy on major adverse cardiac and cerebrovascular events (14.0% versus 16.3%; hazard ratio, 0.86; 95% confidence interval, 0.63-1.18) or death (1.4% versus 2.1%) or death/AMI recurrence/stroke (2.9% versus 4.7%) was identified in comparison with controls. No changes in ejection fraction (mean difference: 0.96%; 95% confidence interval, -0.2 to 2.1), end-diastolic volume, or systolic volume were observed compared with controls. These results were not influenced by anterior AMI location, reduced baseline ejection fraction, or the use of MRI for assessing left ventricular parameters. CONCLUSIONS: This meta-analysis of individual patient data from randomized trials in patients with recent AMI revealed that intracoronary cell therapy provided no benefit, in terms of clinical events or changes in left ventricular fun

Published
2015

45. 33 - Challenges between clinical sites and cell therapy facilities in the excellent trial (expanded cell endocardiac transplantation), a phase I/IIb clinical trial

Author

Criquet, A., Mai, E., Saucourt, C., Vogt, S., Giganti, P., Baron, S., Roncalli, J., Lairez, O., Lagente, C., Lebrin, M., Ioannides, K., Manrique, A., Saloux, E., Leroux, L., Goin, V., Roubille, F., Lefèvre, T., Hovasse, T., Vanzetto, G., Derenne, S., Tertrais, K., Newby, D., Cruden, N., Mills, N., Greenwood, J., Wheatcroft, S., Dickinson, A., Black, A., and Henon, P.

Published
2017
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46. [Cardiac cellular therapy: from cells to the first clinical uses]

Author

Roncalli J, Leobon B, Massabuau P, Galinier M, Parini A, Pathak A, Philippe Bourin, Aa, Hagege, Menasche P, Fournial G, and Jm, Fauvel

Subjects
Clinical Trials as Topic, Ventricular Dysfunction, Left, Ventricular Remodeling, Cell Transplantation, Myocardium, Myocardial Ischemia, Humans, Coronary Artery Disease, Stem Cell Transplantation
Abstract

Despite the improvement in revascularisation techniques, coronary artery disease remains the principal aetiology of cardiac failure in developed countries. The therapeutic management of cardiac failure has been improved over recent years, yet cardiac failure is still associated with significant morbidity and mortality. As cardiac transplantation lacks donors, techniques that allow myocardial regeneration represent an attractive alternative. To date, several types of cells are under study and are suitable for implantation into infarcted myocardium (myoblasts, medullary stem cells...). Following good preclinical study results, the first human cell therapy trials, using the intramyocardial route, have begun, in the course of aorto-coronary bypass surgery in patients with chronic ischaemic cardiopathy and little altered left ventricular function, and then in those with ventricular dysfunction. Different modes of administration of these cell therapy products are under study and could be envisaged in clinical situations such as just after infarction in order to improve ventricular remodelling with an intracoronary injection technique. As for every new treatment, there are numerous problems to resolve, from understanding the relevant mechanisms of cellular transplantation, to the secondary effects that it could entail. Nevertheless, cardiac cellular transplantation is expanding rapidly and with the evolution of techniques it allows a glimpse of a new field of treatment for cardiac failure.

Published
2005

47. [Identification of viable myocardium in ischemic heart disease with severe left ventricular contractile dysfunction: comparison of myocardial scintigraphy with 99mTc-sestamabi and with 201-thallium]

Author

Brandao S, Cagnac R, Roncalli J, Ja, Lotterie, Elbaz M, Richez F, Galinier M, didier CARRIE, and Mj, Alibelli-Chemarin

Subjects
Male, Technetium Tc 99m Sestamibi, Myocardium, Myocardial Ischemia, Heart, Middle Aged, Sensitivity and Specificity, Thallium Radioisotopes, Ventricular Dysfunction, Left, Exercise Test, Humans, Female, Radiopharmaceuticals, Radionuclide Imaging, Aged
Abstract

The aim of this study was to compare quantitatively uptake of 99mTc-Sestamibi at rest and that of late redistribution of 201Tl in the same patients with severe ischaemic left ventricular dysfunction, and to correlate the uptake of the tracer to regional ventricular dysfunction studied by ECG grated 99Tc-Sestamini. A double isotope myocardial scintigraphy, 201 Thallium at rest/redistribution and 99Tc-Sestamibi at rest and on exercise, was performed in 28 patients with severe postinfarction ischaemic cardiomyopathy (EF= 29 +/- 4%). Quantitative analysis for each patient and each isotope were performed with respect to the number of hits expressed in percentage of the activity of a normal zone in 17 circumferential profiles distributed in 4 zones, that is to say in 476 segments. A score allowed counting of viable and non-viable segments and evaluation of contractile function of the 17 segments with respect to wall motion and systolic thickening. Total concordance of global uptake of the two isotopes was observed in 430 of the 476 segments (90.3%) (r= 0.814, p0.0001), but the 99mTc-Sestamibi uptake was less than 201 Th (71 +/- 23% vs 73 +/- 21%, p= 0.0001). With respect to left ventricular wall motion, uptake of 99mTc-Sestamibi was greater than that of 201Tl in normal or hypokinetic segments but less in akinetic and dyskinetic segments. The difference between the two isotopes was most marked in segments with very severe contractile dysfunction. The authors conclude that the uptake of 99mTc-Sestamibi is correlated with that of late distribution of 201Tl when left ventricular contraction is not too poor and should no longer be considered as only a marker of perfusion but can also be useful in the investigation of myocardial viability.

Published
2005

49. [Revascularization of acute myocardial infarction. Doing better and doing more]

Author

Puel J, Maupas E, Meyer ELBAZ, Charpentier S, Roncalli J, Baixas C, Galinier M, and Carrié D

Subjects
Patient Care Team, Patient Selection, Practice Guidelines as Topic, Myocardial Infarction, Myocardial Revascularization, Humans, Exercise
Abstract

Effectiveness, safety, moderation, complementary, network, consensus, strategy and evaluation are the key words in the therapeutic management of acute myocardial infarction. They focus the development of pharmacological and interventional tools of recanalisation, and the decisions for those who use them. In order to cover a condition for which the patient and doctor alike choose neither time nor place, they lead to linking methods and disciplines together for a united approach. They take account of practice in order to adapt scientific data to the realities of exercise, to justify the given means, and to propose clear, realistic and useful management guidelines to first contact doctors. They deliver the best to the greatest number of patients.

Published
2002

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