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3 results on '"Ronald Nam"'

1. Population-Based Clinical Studies Using Routinely Collected Data in Hong Kong, China: A Systematic Review of Trends and Established Local Practices

Author

Derek Wu, Ronald Nam, Keith Sai Kit Leung, Hamza Waraich, Athaya Purnomo, Oscar Hou In Chou, Francesco Perone, Shubhadarshini Pawar, Fatima Faraz, Haipeng Liu, Jiandong Zhou, Tong Liu, Jeffrey Shi Kai Chan, and Gary Tse

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Routinely collected health data are increasingly used in clinical research. No study has systematically reviewed the temporal trends in the number of publications and analyzed different aspects of local research practices and their variations in Hong Kong, China, with a specific focus on research ethics governance and approval. Methods: PubMed was systematically searched from its inception to March 28, 2023, for studies using routinely collected healthcare data from Hong Kong. Results: A total of 454 studies were included. Between 2000 and 2009, 32 studies were identified. The number of publications increased from 5 to 120 between 2010 and 2022. Of the investigator-led studies using the Hospital Authority (HA)’s cross-cluster data (n = 393), 327 (83.2%) reported receiving ethics approval from a single cluster/university-based REC, whereas 50 studies (12.7%) did not report approval from a REC. For use of the HA Data Collaboration Lab, approval by a single hospital-based or University-based REC is accepted. Repeated submission of identical ethics applications to different RECs is estimated to cost HK$4.2 million yearly. Conclusions: Most studies reported gaining approval from a single cluster REC before retrieval of cross-cluster HA data. Substantial cost savings would result if repeated review of identical ethics applications were not required.

Published
2023
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2. Population-Based Clinical Studies Using Routinely Collected Data in Hong Kong: A Systematic Review of Established Local Practices and Counterfactual Analysis

Author

Derek Wu, Ronald Nam, Keith Sai Kit Leung, Hamza Waraich, Athaya Febriantyo Purnomo, Oscar Hou In Chou, Francesco Perone, Shubhadarshini Pawar, Fatima Faraz, Haipeng Liu, Jiandong Zhou, Tong Liu, Jeffrey Chan, and Gary Tse

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2023
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3. COVID-19 vaccination and carditis in children and adolescents: a systematic review and meta-analysis

Author

Oscar Hou In, Chou, Jonathan, Mui, Cheuk To, Chung, Danny, Radford, Simon, Ranjithkumar, Endurance, Evbayekha, Ronald, Nam, Levent, Pay, Danish Iltaf, Satti, Sebastian, Garcia-Zamora, George, Bazoukis, Göksel, Çinier, Sharen, Lee, Vassilios S, Vassiliou, Tong, Liu, Gary, Tse, and Ian Chi Kei, Wong

Subjects
Adult, Male, Vaccines, COVID-19 Vaccines, Adolescent, Vaccination, COVID-19, Contrast Media, Infant, Gadolinium, General Medicine, Myocarditis, Young Adult, Humans, Cardiology and Cardiovascular Medicine, Child
Abstract

Background Coronavirus Disease-2019 (COVID-19) vaccination has been associated with the development of carditis, especially in children and adolescent males. However, the rates of these events in the global setting have not been explored in a systematic manner. The aim of this systematic review and meta-analysis is to investigate the rates of carditis in children and adolescents receiving COVID-19 vaccines. Methods PubMed, Embase and several Latin American databases were searched for studies. The number of events, and where available, at-risk populations were extracted. Rate ratios were calculated and expressed as a rate per million doses received. Subgroup analysis based on the dose administered was performed. Subjects ≤ 19 years old who developed pericarditis or myocarditis following COVID-19 vaccination were included. Results A total of 369 entries were retrieved. After screening, 39 articles were included. Our meta-analysis found that 343 patients developed carditis after the administration of 12,602,625 COVID-19 vaccination doses (pooled rate per million: 37.76; 95% confidence interval [CI] 23.57, 59.19). The rate of carditis was higher amongst male patients (pooled rate ratio: 5.04; 95% CI 1.40, 18.19) and after the second vaccination dose (pooled rate ratio: 5.60; 95% CI 1.97, 15.89). In 301 cases of carditis (281 male; mean age: 15.90 (standard deviation [SD] 1.52) years old) reported amongst the case series/reports, 261 patients were reported to have received treatment. 97.34% of the patients presented with chest pain. The common findings include ST elevation and T wave abnormalities on electrocardiography. Oedema and late gadolinium enhancement in the myocardium were frequently observed in cardiac magnetic resonance imaging (CMR). The mean length of hospital stay was 3.91 days (SD 1.75). In 298 out of 299 patients (99.67%) the carditis resolved with or without treatment. Conclusions Carditis is a rare complication after COVID-19 vaccination across the globe, but the vast majority of episodes are self-limiting with rapid resolution of symptoms within days. Graphical abstract Central illustration. Balancing the benefits of vaccines on COVID-19-caused carditis and post-vaccination carditis.

Published
2022

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