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2. Reproductive Tourism

Author

Ron-El, Raphael, Schlegel, Peter N., editor, Fauser, Bart C., editor, Carrell, Douglas T., editor, and Racowsky, Catherine, editor

Published
2013
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5. Difficult ICSI Cases: An Israeli Survey

Author

Soffer, Yigal, Raziel, Arie, Friedler, Shevach, Strassburger, Deborah, Ron-El, Raphael, Hamamah, Samir, editor, Olivennes, François, editor, Mieusset, Roger, editor, and Frydman, René, editor

Published
1999
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6. Fertilizing Capability of Frozen-Thawed Immotile Sperm

Author

Ron-El, Raphael, Strassburger, Deborah, Soffer, Yigal, Friedler, Shevach, Komarovski, Daphna, Bern, Orna, Kasterstein, Esti, Schachter, Mory, Raziel, Arie, Hamamah, Samir, editor, Olivennes, François, editor, Mieusset, Roger, editor, and Frydman, René, editor

Published
1999
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27. Abstract PR05: Utilizing electronic fertility clinic records and registry linkage to establish a retrospective population-based cohort study to evaluate the association between in vitro fertilization (IVF) and subsequent cancer risk in women

Author

Trabert, Britton, primary, Hirsh-Yechezkel, Galit, additional, Farhi, Adel, additional, Zaslavsky, Inna, additional, Elizur, Shai E., additional, Kahana, Arik, additional, Orvieto, Raoul, additional, Holzer, Hananel, additional, Calderon, Ilan, additional, Friedler, Shevach, additional, Shalom-Paz, Einat, additional, Ron-El, Raphael, additional, Raziel, Arie, additional, Brinton, Louise A., additional, and Lerner-Geva, Liat, additional

Published
2020
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38. How Are They Doing? Neurodevelopmental Outcomes at School Age of Children Born Following Assisted Reproductive Treatments.

Author

Farhi, Adel, Glasser, Saralee, Gabis, Lidia V., Hirsh-Yechezkel, Galit, Frank, Shay, Brinton, Louise, Scoccia, Bert, Ron-El, Raphael, Orvieto, Raoul, and Lerner-Geva, Liat

Subjects
CHILDREN with autism spectrum disorders, SCHOOL children, APRAXIA, AUTISM spectrum disorders, TELEPHONE interviewing
Abstract

Objective: The purpose of this study was to assess major neurodevelopmental aspects of children conceived by assisted reproductive treatments compared to spontaneously conceived children during the early school years. Material & Methods: In this follow-up study, mothers of 358 children born following assisted reproductive treatments and 401 spontaneouslyconceived children were interviewed by telephone regarding their children's health and development, when the children were 7-8 years old. The main outcomes were maternal responses to 4 questionnaires: Developmental Coordination Disorder Questionnaire, Short Sensory Profile, Autism Spectrum Screening Questionnaire, and the Attention-deficit hyperactive disorder (ADHD) Child Symptom Inventory-4 subscale. Mothers reported diagnoses of ADHD and autism spectrum disorder. Results: No significant differences were found between the groups in Developmental Coordination Disorder Questionnaire or Short Sensory Profile scores upon univariate or multivariable analyses. There was a slightly higher but nonsignificant rate of diagnosed ADHD among children in the assisted reproductive treatment group (9.6% vs 5.5%; P < .18); on multivariable analysis, a nonsignificant increase in ADHD was also found for assisted reproductive treatment children (hazard ratio 1.45, 95% confidence interval 0.81-2.61). Regarding the Child Symptom Inventory-4 criteria for ADHD among the children who had never been diagnosed, there was also a slightly higher but nonsignificant rate among the assisted reproductive treatments compared to spontaneously-conceived children on univariate (2.4% vs 1.8%; P < .50) and multivariable analysis (odds ratio 0.88, 95% confidence interval 0.27-2.86). Autism spectrum disorder diagnosis or Autism Spectrum Screening Questionnaire scores were not significantly different; however, 5 of the 6 children with autism spectrum disorder diagnoses were in the assisted reproductive treatment group. Conclusions: Neurodevelopmental measures were similar in both groups, although nonconclusive regarding ADHD and autism spectrum disorder risk. These findings contribute to the knowledge regarding long-term assisted reproductive treatment outcomes. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Ovarian pregnancy: a report of twenty cases in one institution

Author

Raziel, Arieh, Golan, Abraham, Pansky, Mordechai, Ron-El, Raphael, Bukovsky, Ian, and Caspi, Eliahu

Subjects
Ovaries -- Physiological aspects, Pregnancy, Ectopic -- Case studies, Health
Abstract

In ectopic or extrauterine pregnancies, the fertilized egg implants in tissues other than the uterus. Implantation in the ovary is one of the rarest of ectopic pregnancies and is difficult to diagnose. The symptoms, diagnosis, and treatment of 20 cases of ovarian pregnancy are described in this article. The ovarian pregnancies represented 3.3 percent of all ectopic pregnancies at one institution during a 19-year period, a rate similar to that reported in the literature. However, the prevalence in this group increased during the later years. Eighteen of 20 patients used the intrauterine device (IUD) for contraception. Abdominal pain and menstrual irregularity were the most frequently reported symptoms. Ovarian pregnancy leads to increased growth of blood vessels in the ovary, with associated rupture in many cases. Circulatory collapse due to loss of blood occurred in six patients. Thirteen of the 20 cases were suspected of having ectopic pregnancy before surgery, while other ovarian or abdominal disorders were suspected in the rest. Among eight fertile patients who did not continue contraceptive use and who were available for follow-up study, seven had normal pregnancies and one had an ectopic pregnancy which occurred in the fallopian tubes. Ovarian pregnancies may be associated with IUD use because IUDs (untreated with copper or progesterone) may effectively prevent only uterine and tubal pregnancies. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

43. Possible risk for cancer among children born following assisted reproductive technology in Israel

Author

Lerner-Geva, Liat, primary, Boyko, Valentina, additional, Ehrlich, Shelley, additional, Mashiach, Shlomo, additional, Hourvitz, Ariel, additional, Haas, Jigal, additional, Margalioth, Ehud, additional, Levran, David, additional, Calderon, Ilan, additional, Orvieto, Raoul, additional, Ellenbogen, Adrian, additional, Meyerovitch, Joseph, additional, Ron-El, Raphael, additional, and Farhi, Adel, additional

Published
2016
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49. Pigment epithelium-derived factor regulation by human chorionic gonadotropin in granulosa cells.

Author

Bar-Joseph, Hadas, Ben-Ami, Ido, Ron-El, Raphael, Shalgi, Ruth, and Chuderland, Dana

Subjects
GONADOTROPIN, CELLS
Abstract

Human chorionic gonadotropin (hCG) is a known trigger of ovarian hyperstimulation syndrome (OHSS), a potentially life-threatening complication of assisted reproduction. Administration of hCG results in the release of vascular endothelial growth factor (VEGF) from the ovary. We have previously shown that expression of pigment epithelium-derived factor (PEDF) in granulosa cell line is regulated by hCG, reciprocally to VEGF, and that the PEDF-VEGF balance is impaired in OHSS. Our aim was to explore the signaling network by which hCG downregulates the expression of PEDF mRNA and protein in granulosa cells. We applied specific chemical inhibitors and stimuli to human primary granulosa cells and rat granulosa cell line. We found that PKA and protein kinase C, as well as EGFR, ERK1/2 and PI3K, participate in the signaling network. The finding that hCG-induced PEDF downregulation and VEGF upregulation are mediated by similar signaling cascades emphasizes the delicate regulation of ovarian angiogenesis. [ABSTRACT FROM AUTHOR]

Published
2016
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