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1. IRON: A retrospective international multicenter study on robotic versus laparoscopic versus open approach in gallbladder cancer

Author

Ielpo, Benedetto, Vittoria d’Addetta, Maria, Burdio, Fernando, Sanchez-Velazquez, Patricia, Vellalta, Gemma, Cremona, Simone, Villamonte, Maria, Morelli, Luca, Furbetta, Niccoló, Di Franco, Gregorio, Comandatore, Annalisa, Mastrangelo, Mattia, Mazzone, Chiara, Masetti, Michele, Offi, Maria Fortuna, Geraldi, Eleonora, Aldrighetti, Luca, Ingallinella, Sara, Ratti, Francesca, Rosso, Edoardo, De Blasi, Vito, Anselmo, Alessandro, Conte, Luigi Eduardo, Memeo, Riccardo, Delvecchio, Antonella, Sukandy, Iswanto, Moraldi, Luca, Grazi, Gian Luca, Spampinato, Marcello G., D'Ugo, Stefano, Heng Chiow, Adrian Kah, Yi Yee, Francis Zheng, Tan, Hiang Jin, Thiruchelvam, Nita, Lancellotti, Francesco, Satyadas, Thomas, Fedi, Massimo, De Vincenti, Rosita, Leo, Francesca, Pesi, Benedetta, Belli, Andrea, Izzo, Francesco, Cutolo, Carmen, Romano, Fabrizio, Scotti, Mauro Alessandro, Carissimi, Francesca, Garancini, Mattia, Ciulli, Cristina, Mazzola, Michele, Ferrari, Giovanni, Zironda, Andrea, Giani, Alessandro, Giuliani, Giuseppe, Federica Dorma, Maria Pia, Guerra, Francesco, Di Marino, Michele, Coratti, Andrea, Mina, Elisa, Romanzi, Andrea, Prieto, Mikel, Perfecto, Arkaitz, Ioannidis, Orestis, Lombardeas, Odysseas, Ardito, Francesco, Giuliante, Felice, Lopez-Lopez, Victor, Robles-Campos, Ricardo, Martinie, John, Mccarron, Frances, Romito, Raffaele, Nicolosi, Filadelfio Massimiliano, Ben Dhaou, Anis, Chamekh, Atef, Rezgui, Bochra, Pacilli, Mario, Pavone, Giovanna, Tartaglia, Nicola, Gupta, Rahul, Grego, Davide Giovanni, Ricci, Claudio, Pata, Francesco, Nardo, Bruno, Facundo, Helena, Guevara, Oscar, Lorenzin, Dario, Guglielmi, Alfredo, Ruzzenente, Andrea, Valle, Valentina, Alberto, Mangano, Giulianotti, PierCristoforo, Vicente, Emilio, Ferri, Valentina, Avella, Pasquale, Calise, Fulvio, Rocca, Aldo, Bianchi, Paolo, Rompianesi, Gianluca, Troisi, Roberto I., Donadon, Matteo, di Martino, Marcello, Podda, Mauro, Pisanu, Adolfo, Torzilli, Guido, Vittoria d'Addetta, Maria, Di Martino, Marcello, and Giulianotti, Pier Cristoforo

Published
2024
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2. REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer

Author

Boggi, Ugo, Kauffmann, Emanuele, Napoli, Niccolò, Barreto, S. George, Besselink, Marc G., Fusai, Giuseppe K., Hackert, Thilo, Abu Hilal, Mohammad, Marchegiani, Giovanni, Salvia, Roberto, Shrikhande, Shailesh V., Truty, Mark, Werner, Jens, Wolfgang, Christopher L., Bannone, Elisa, Capretti, Giovanni, Cattelani, Alice, Coppola, Alessandro, Cucchetti, Alessandro, De Sio, Davide, Di Dato, Armando, Di Meo, Giovanna, Fiorillo, Claudio, Gianfaldoni, Cesare, Ginesini, Michael, Hidalgo Salinas, Camila, Lai, Quirino, Miccoli, Mario, Montorsi, Roberto, Pagnanelli, Michele, Poli, Andrea, Ricci, Claudio, Sucameli, Francesco, Tamburrino, Domenico, Viti, Virginia, Addeo, Pietro F., Alfieri, Sergio, Bachellier, Philippe, Baiocchi, Gian Luca, Balzano, Gianpaolo, Barbarello, Linda, Brolese, Alberto, Busquets, Juli, Butturini, Giovanni, Caniglia, Fabio, Caputo, Damiano, Casadei, Riccardo, Chunhua, Xi, Colangelo, Ettore, Coratti, Andrea, Costa, Francesca, Crafa, Francesco, Dalla Valle, Raffaele, De Carlis, Luciano, de Wilde, Roeland F., Del Chiaro, Marco, Di Benedetto, Fabrizio, Di Sebastiano, Pierluigi, Dokmak, Safi, Hogg, Melissa, Egorov, Vyacheslav I., Ercolani, Giorgio, Ettorre, Giuseppe Maria, Falconi, Massimo, Ferrari, Giovanni, Ferrero, Alessandro, Filauro, Marco, Giardino, Alessandro, Grazi, Gian Luca, Gruttadauria, Salvatore, Izbicki, Jakob R, Jovine, Elio, Katz, Matthew, Keck, Tobias, Khatkov, Igor, Kiguchi, Gozo, Kooby, David, Lang, Hauke, Lombardo, Carlo, Malleo, Giuseppe, Massani, Marco, Mazzaferro, Vincenzo, Memeo, Riccardo, Miao, Yi, Mishima, Kohei, Molino, Carlo, Nagakawa, Yuichi, Nakamura, Masafumi, Nardo, Bruno, Panaro, Fabrizio, Pasquali, Claudio, Perrone, Vittorio, Rangelova, Elena, Liu, Rong, Romagnoli, Renato, Romito, Raffaele, Rosso, Edoardo, Schulick, Richard, Siriwardena, Ajith, Spampinato, Marcello Giuseppe, Strobel, Oliver, Testini, Mario, Troisi, Roberto Ivan, Uzunoglo, Faik G., Valente, Roberto, Veneroni, Luigi, Zerbi, Alessandro, Vicente, Emilio, Vistoli, Fabio, Vivarelli, Marco, Wakabayashi, Go, Zanus, Giacomo, Zureikat, Amer, Zyromski, Nicholas J., Coppola, Roberto, D’Andrea, Vito, Davide, José, Dervenis, Christos, Frigerio, Isabella, Konlon, Kevin C., Michelassi, Fabrizio, Montorsi, Marco, Nealon, William, Portolani, Nazario, Sousa Silva, Donzília, Bozzi, Giuseppe, Ferrari, Viviana, Trivella, Maria G., Cameron, John, Clavien, Pierre-Alain, Asbun, Horacio J., Boraschi, Piero, Campani, Daniela, Cappelli, Carla, Cioni, Roberto, Dominici, Massimo, Esposito, Irene, Gambacorta, Maria A, Marciano, Emanuele, Masi, Gianluca, Morganti, Alessio, Mutignani, Massimiliano, Neri, Emanuele, Paiar, Fabiola, Reni, Michele, Rotondo, Maria Isabella, Silvestris, Nicola, Tortora, Giampaolo, Vasile, Enrico, and Volterrani, Duccio

Published
2024
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4. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy

Author

de’Angelis, Nicola, Catena, Fausto, Memeo, Riccardo, Coccolini, Federico, Martínez-Pérez, Aleix, Romeo, Oreste M., De Simone, Belinda, Di Saverio, Salomone, Brustia, Raffaele, Rhaiem, Rami, Piardi, Tullio, Conticchio, Maria, Marchegiani, Francesco, Beghdadi, Nassiba, Abu-Zidan, Fikri M., Alikhanov, Ruslan, Allard, Marc-Antoine, Allievi, Niccolò, Amaddeo, Giuliana, Ansaloni, Luca, Andersson, Roland, Andolfi, Enrico, Azfar, Mohammad, Bala, Miklosh, Benkabbou, Amine, Ben-Ishay, Offir, Bianchi, Giorgio, Biffl, Walter L., Brunetti, Francesco, Carra, Maria Clotilde, Casanova, Daniel, Celentano, Valerio, Ceresoli, Marco, Chiara, Osvaldo, Cimbanassi, Stefania, Bini, Roberto, Coimbra, Raul, Luigi de’Angelis, Gian, Decembrino, Francesco, De Palma, Andrea, de Reuver, Philip R., Domingo, Carlos, Cotsoglou, Christian, Ferrero, Alessandro, Fraga, Gustavo P., Gaiani, Federica, Gheza, Federico, Gurrado, Angela, Harrison, Ewen, Henriquez, Angel, Hofmeyr, Stefan, Iadarola, Roberta, Kashuk, Jeffry L., Kianmanesh, Reza, Kirkpatrick, Andrew W., Kluger, Yoram, Landi, Filippo, Langella, Serena, Lapointe, Real, Le Roy, Bertrand, Luciani, Alain, Machado, Fernando, Maggi, Umberto, Maier, Ronald V., Mefire, Alain Chichom, Hiramatsu, Kazuhiro, Ordoñez, Carlos, Patrizi, Franca, Planells, Manuel, Peitzman, Andrew B., Pekolj, Juan, Perdigao, Fabiano, Pereira, Bruno M., Pessaux, Patrick, Pisano, Michele, Puyana, Juan Carlos, Rizoli, Sandro, Portigliotti, Luca, Romito, Raffaele, Sakakushev, Boris, Sanei, Behnam, Scatton, Olivier, Serradilla-Martin, Mario, Schneck, Anne-Sophie, Sissoko, Mohammed Lamine, Sobhani, Iradj, ten Broek, Richard P., Testini, Mario, Valinas, Roberto, Veloudis, Giorgos, Vitali, Giulio Cesare, Weber, Dieter, Zorcolo, Luigi, Giuliante, Felice, Gavriilidis, Paschalis, Fuks, David, and Sommacale, Daniele

Published
2021
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6. Computed Tomography Imaging Evaluation of Pancreatic Density andMuscularMass as Predictive Risk Factors for Pancreatic Fistula Formation after Duodenocephalopancreasectomy.

Author

Calabrò, Naomi, Borraccino, Chiara, Garlisi, Christian, Bongiovanni, Teresa, Basile, Paola, Abu-Omar, Ahmed, Scaglione, Mariano, Romito, Raffaele, and Carriero, Alessandro

Subjects
PANCREATIC fistula, DENSITY, ADENOCARCINOMA, DISEASE risk factors, COMPUTED tomography, PANCREATIC diseases
Abstract

The aim of this study was to investigate the predictive role of preoperative pancreatic density and muscular mass, assessed via CT imaging, in patients undergoing duodenocephalopancreasectomy, specifically in relation to the occurrence of postoperative pancreatic fistula (POPF). A retrospective analysis was conducted on a cohort of 57 consecutive patients who had been diagnosed with cephalo-pancreatic disease and had undergone duodenocephalopancreasectomy in the last five years. The most prevalent pathologies observed were ductal adenocarcinoma (29.2%), biliary adenocarcinoma (12.9%), and duodenal and papillary adenocarcinoma (13.9%). We collected information about age, sex, histopathological findings, type of surgery, presence or absence of pancreatic fistula, pancreatic density on preoperative CT images, and muscular area, calculated at the level of the L3 vertebra using "3D Slicer" software. Our data show that 28% of patients developed a pancreatic fistula, with an average attenuation of pancreatic density of 27 HU, which was lower than that observed in the non-fistula group (33.31 HU). However, statistical analysis did not reveal a significant association between low pancreatic density and fistula development. Therefore, our findings do not establish a significant association between pancreatic fistula and pancreatic density, aligning with the existing literature on the subject. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Exposure to Plasma From Non-alcoholic Fatty Liver Disease Patients Affects Hepatocyte Viability, Generates Mitochondrial Dysfunction, and Modulates Pathways Involved in Fat Accumulation and Inflammation

Author

Grossini, Elena, primary, Garhwal, Divya Praveen, additional, Calamita, Giuseppe, additional, Romito, Raffaele, additional, Rigamonti, Cristina, additional, Minisini, Rosalba, additional, Smirne, Carlo, additional, Surico, Daniela, additional, Bellan, Mattia, additional, and Pirisi, Mario, additional

Published
2021
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11. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy

Author

DeAngelis, Nicola, Catena, Fausto, Memeo, Riccardo, Coccolini, Federico, Martinez-Perez, Aleix, Romeo, Oreste M., De Simone, Belinda, Di Saverio, Salomone, Brustia, Raffaele, Rhaiem, Rami, Piardi, Tullio, Conticchio, Maria, Marchegiani, Francesco, Beghdadi, Nassiba, Abu-Zidan, Fikri M., Alikhanov, Ruslan, Allard, Marc-Antoine, Allievi, Niccolo, Amaddeo, Giuliana, Ansaloni, Luca, Andersson, Roland, Andolfi, Enrico, Azfar, Mohammad, Bala, Miklosh, Benkabbou, Amine, Ben-Ishay, Offir, Bianchi, Giorgio, Biffl, Walter L., Brunetti, Francesco, Carra, Maria Clotilde, Casanova, Daniel, Celentano, Valerio, Ceresoli, Marco, Chiara, Osvaldo, Cimbanassi, Stefania, Bini, Roberto, Coimbra, Raul, Luigi deAngelis, Gianm, Decembrino, Francesco, De Palma, Andrea, de Reuver, Philip R., Domingo, Carlos, Cotsoglou, Christian, Ferrero, Alessandro, Fraga, Gustavo P., Gaiani, Federica, Gheza, Federico, Gurrado, Angela, Harrison, Ewen, Henriquez, Angel, Hofmeyr, Stefan, Iadarola, Roberta, Kashuk, Jeffry L., Kianmanesh, Reza, Kirkpatrick, Andrew W., Kluger, Yoram, Landi, Filippo, Langella, Serena, Lapointe, Real, Le Roy, Bertrand, Luciani, Alain, Machado, Fernando, Maggi, Umberto, Maier, Ronald V., Mefire, Alain Chichom, Hiramatsu, Kazuhiro, Ordonez, Carlos, Patrizi, Franca, Planells, Manuel, Peitzman, Andrew B., Pekolj, Juan, Perdigao, Fabiano, Pereira, Bruno M., Pessaux, Patrick, Pisano, Michele, Puyana, Juan Carlos, Rizoli, Sandro, Portigliotti, Luca, Romito, Raffaele, Sakakushev, Boris, Sanei, Behnam, Scatton, Olivier, Serradilla-Martin, Mario, Schneck, Anne-Sophie, Sissoko, Mohammed Lamine, Sobhani, Iradj, ten Broek, Richard P., Testini, Mario, Valinas, Roberto, Veloudis, Giorgos, Vitali, Giulio Cesare, Weber, Dieter, Zorcolo, Luigi, Giuliante, Felice, Gavriilidis, Paschalis, Fuks, David, Sommacale, Daniele, DeAngelis, Nicola, Catena, Fausto, Memeo, Riccardo, Coccolini, Federico, Martinez-Perez, Aleix, Romeo, Oreste M., De Simone, Belinda, Di Saverio, Salomone, Brustia, Raffaele, Rhaiem, Rami, Piardi, Tullio, Conticchio, Maria, Marchegiani, Francesco, Beghdadi, Nassiba, Abu-Zidan, Fikri M., Alikhanov, Ruslan, Allard, Marc-Antoine, Allievi, Niccolo, Amaddeo, Giuliana, Ansaloni, Luca, Andersson, Roland, Andolfi, Enrico, Azfar, Mohammad, Bala, Miklosh, Benkabbou, Amine, Ben-Ishay, Offir, Bianchi, Giorgio, Biffl, Walter L., Brunetti, Francesco, Carra, Maria Clotilde, Casanova, Daniel, Celentano, Valerio, Ceresoli, Marco, Chiara, Osvaldo, Cimbanassi, Stefania, Bini, Roberto, Coimbra, Raul, Luigi deAngelis, Gianm, Decembrino, Francesco, De Palma, Andrea, de Reuver, Philip R., Domingo, Carlos, Cotsoglou, Christian, Ferrero, Alessandro, Fraga, Gustavo P., Gaiani, Federica, Gheza, Federico, Gurrado, Angela, Harrison, Ewen, Henriquez, Angel, Hofmeyr, Stefan, Iadarola, Roberta, Kashuk, Jeffry L., Kianmanesh, Reza, Kirkpatrick, Andrew W., Kluger, Yoram, Landi, Filippo, Langella, Serena, Lapointe, Real, Le Roy, Bertrand, Luciani, Alain, Machado, Fernando, Maggi, Umberto, Maier, Ronald V., Mefire, Alain Chichom, Hiramatsu, Kazuhiro, Ordonez, Carlos, Patrizi, Franca, Planells, Manuel, Peitzman, Andrew B., Pekolj, Juan, Perdigao, Fabiano, Pereira, Bruno M., Pessaux, Patrick, Pisano, Michele, Puyana, Juan Carlos, Rizoli, Sandro, Portigliotti, Luca, Romito, Raffaele, Sakakushev, Boris, Sanei, Behnam, Scatton, Olivier, Serradilla-Martin, Mario, Schneck, Anne-Sophie, Sissoko, Mohammed Lamine, Sobhani, Iradj, ten Broek, Richard P., Testini, Mario, Valinas, Roberto, Veloudis, Giorgos, Vitali, Giulio Cesare, Weber, Dieter, Zorcolo, Luigi, Giuliante, Felice, Gavriilidis, Paschalis, Fuks, David, and Sommacale, Daniele

Abstract

Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.

Published
2021
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13. Nonhepatic glucose production in humans

Author

Battezzati, Alberto, Caumo, Andrea, Martino, Francesca, Sereni, Lucia Piceni, Coppa, Jorgelina, Romito, Raffaele, Ammatuna, Mario, Regalia, Enrico, Matthews, Dwight E., Mazzaferro, Vincenzo, and Luzi, Livio

Subjects
Amino acids -- Research, Dextrose -- Research, Glucose -- Research, Biological sciences
Abstract

Extrahepatic glucose release was evaluated during the anhepatic phase of liver transplantation in 14 recipients for localized hepatocarcinoma with mild or absent cirrhosis, who received a bolus of [6,6-[sup.2][H.sub.2]]glueose and L-[3-[sup.3]C]alanine or L-[1,2-[sup.13][C.sub.2]]glutamine to measure glucose kinetics and to prove whether gluconeogenesis occurred from alanine and glutamine. Twelve were studied again 7 mo thereafter along with seven healthy subjects. At the beginning of the anhepatic phase, plasma glucose was increased and then declined by 15%/h. The right kidney released glucose, with an arteriovenous gradient of -3.7 mg/dl. Arterial and portal glucose concentrations were similar. The glucose clearance was 25% reduced, but glucose uptake was similar to that of the control groups. Glucose production was 9.5 [+ or -] 0.9 [micro]mol * [kg.sup.-1] * [min.sup.-1], 30% less than in controls. Glucose became enriched with [sup.13]C from alanine and especially glutamine, proving the extrahepatic gluconeogenesis. The gluconeogenic precursors alanine, glutamine, lactate, pyruvate, and glycerol, insulin, and the counterregulatory hormones epinephrine, cortisol, growth hormone, and glucagon were increased severalfold. Extrahepatic organs synthesize glucose at a rate similar to that of postabsorptive healthy subjects when hepatic production is absent, and gluconeogenic precursors and counterregulatory hormones are markedly increased. The kidney is the main, but possibly not the unique, source of extrahepatic glucose production. kidney; intestines; amino acids

Published
2004

18. Correction to: Diffusion, outcomes and implementation of minimally invasive liver surgery: a snapshot from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry (Updates in Surgery, (2017), 69, 3, (271-283), 10.1007/s13304-017-0489-x)

Author

Aldrighetti, Luca, Ratti, Francesca, Cillo, Umberto, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Guglielmi, Alfredo, Giuliante, Felice, Calise, Fulvio, Dalla Valle, Raffaele, Mazzaferro, Vincenzo, Jovine, Elio, De Carlis, Luciano Gregorio, Boggi, Ugo, Gruttadauria, Salvatore, Di Benedetto, Fabrizio, Reggiani, Paolo, Berti, Stefano, Ceccarelli, Graziano, Vincenti, Leonardo, Belli, Giulio, Torzilli, Guido, Zamboni, Fausto, Coratti, Andrea, Mezzatesta, Pietro, Santambrogio, Roberto, Navarra, Giuseppe, Giuliani, Antonio, Pinna, Antonio Daniele, Parisi, Amilcare, Colledan, Michele, Slim, Abdallah, Antonucci, Adelmo, Grazi, Gian Luca, Frena, Antonio, Sgroi, Giovanni, Brolese, Alberto, Morelli, Luca, Floridi, Antonio, Patriti, Alberto, Veneroni, Luigi, Ercolani, Giorgio, Boni, Luigi, Maida, Pietro, Griseri, Guido, Percivale, Andrea, Filauro, Marco, Guerriero, Silvio, Tisone, Giuseppe, Romito, Raffaele, Tedeschi, Umberto, Zimmitti, Giuseppe, Aldrighetti, L, Ratti, F, Cillo, U, Ferrero, A, Ettorre, G, Guglielmi, A, Giuliante, F, Calise, F, Dalla Valle, R, Mazzaferro, V, Jovine, E, De Carlis, L, Boggi, U, Gruttadauria, S, Di Benedetto, F, Reggiani, P, Berti, S, Ceccarelli, G, Vincenti, L, Belli, G, Torzilli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Ercolani, G, Boni, L, Maida, P, Griseri, G, Percivale, A, Filauro, M, Guerriero, S, Tisone, G, Romito, R, Tedeschi, U, and Zimmitti, G

Subjects
Surgery, Settore MED/18
Abstract

A technical error led to incorrect rendering of the author group in this article. The correct authorship is as follows: Luca Aldrighetti, Francesca Ratti, Umberto Cillo, Alessandro Ferrero, Giuseppe Maria Ettorre, Alfredo Guglielmi, Felice Giuliante, Fulvio Calise on behalf of the Italian Group of Minimally Invasive Liver Surgery (I GO MILS) The collaborators are: Raffaele Dalla Valle, AOU Parma, Parma; Vincenzo Mazzaferro, Istituto Nazionale Tumori, Milano; Elio Jovine, Ospedale Maggiore, Bologna; Luciano Gregorio De Carlis, Ospedale Niguarda Ca’ Granda, Milano; Ugo Boggi, AOU Pisana, Pisa; Salvatore Gruttadauria, ISMETT, Palermo; Fabrizio Di Benedetto, AOU Policlinico di Modena, Modena; Paolo Reggiani, Ospedale Maggiore Policlinico, Milano; Stefano Berti, Ospedale Civile S.Andrea, La Spezia; Graziano Ceccarelli, Ospedale San Donato, Arezzo; Leonardo Vincenti, AOU Consorziale Policlinico, Bari; Giulio Belli, Ospedale SM Loreto Nuovo, Napoli; Guido Torzilli, Istituto Clinico Humanitas, Rozzano; Fausto Zamboni, Ospedale Brotzu, Cagliari; Andrea Coratti, AOU Careggi, Firenze; Pietro Mezzatesta, Casa di Cura La Maddalena, Palermo; Roberto Santambrogio, AO San Paolo, Milano; Giuseppe Navarra, AOU Policlinico G. Martino, Messina; Antonio Giuliani, AO R.N. Cardarelli, Napoli; Antonio Daniele Pinna, Policlinico Sant’Orsola Malpighi, Bologna; Amilcare Parisi, AO Santa Maria di Terni, Terni; Michele Colledan, AO Papa Giovanni XXIII, Bergamo; Abdallah Slim, AO Desio e Vimercate, Vimercate; Adelmo Antonucci, Policlinico di Monza, Monza; Gian Luca Grazi, Istituto Nazionale Tumori Regina Elena, Roma; Antonio Frena, Ospedale Centrale, Bolzano; Giovanni Sgroi, AO Treviglio-Caravaggio, Treviglio; Alberto Brolese, Ospedale S.Chiara, Trento; Luca Morelli, AOU Pisana, Pisa; Antonio Floridi, AO Ospedale Maggiore, Crema; Alberto Patriti, Ospedale San Matteo degli Infermi, Spoleto; Luigi Veneroni, Ospedale Infermi AUSL Romagna, Rimini; Giorgio Ercolani, Ospedale Morgagni Pierantoni, Forlì; Luigi Boni, AOU Fondazione Macchi, Varese; Pietro Maida, Ospedale Villa Betania, Napoli; Guido Griseri, Ospedale San Paolo, Savona; Andrea Percivale, Ospedale Santa Corona, Pietraligure; Marco Filauro, AO Galliera, Genova; Silvio Guerriero, Ospedale San Martino, Belluno; Giuseppe Tisone, Policlinico Tor Vergata, Roma; Raffaele Romito, AOU Maggiore della Carità, Novara; Umberto Tedeschi, AOU Integrata Verona, Verona; Giuseppe Zimmitti, Fondazione Poliambulanza, Brescia.

Published
2018

20. Correction to: Diffusion, outcomes and implementation of minimally invasive liver surgery: a snapshot from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry (Updates in Surgery, (2017), 69, 3, (271-283), 10.1007/s13304-017-0489-x)

Author

Aldrighetti, L, Ratti, F, Cillo, U, Ferrero, A, Ettorre, G, Guglielmi, A, Giuliante, F, Calise, F, Dalla Valle, R, Mazzaferro, V, Jovine, E, De Carlis, L, Boggi, U, Gruttadauria, S, Di Benedetto, F, Reggiani, P, Berti, S, Ceccarelli, G, Vincenti, L, Belli, G, Torzilli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Ercolani, G, Boni, L, Maida, P, Griseri, G, Percivale, A, Filauro, M, Guerriero, S, Tisone, G, Romito, R, Tedeschi, U, Zimmitti, G, Aldrighetti, Luca, Ratti, Francesca, Cillo, Umberto, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Guglielmi, Alfredo, Giuliante, Felice, Calise, Fulvio, Dalla Valle, Raffaele, Mazzaferro, Vincenzo, Jovine, Elio, De Carlis, Luciano Gregorio, Boggi, Ugo, Gruttadauria, Salvatore, Di Benedetto, Fabrizio, Reggiani, Paolo, Berti, Stefano, Ceccarelli, Graziano, Vincenti, Leonardo, Belli, Giulio, Torzilli, Guido, Zamboni, Fausto, Coratti, Andrea, Mezzatesta, Pietro, Santambrogio, Roberto, Navarra, Giuseppe, Giuliani, Antonio, Pinna, Antonio Daniele, Parisi, Amilcare, Colledan, Michele, Slim, Abdallah, Antonucci, Adelmo, Grazi, Gian Luca, Frena, Antonio, Sgroi, Giovanni, Brolese, Alberto, Morelli, Luca, Floridi, Antonio, Patriti, Alberto, Veneroni, Luigi, Ercolani, Giorgio, Boni, Luigi, Maida, Pietro, Griseri, Guido, Percivale, Andrea, Filauro, Marco, Guerriero, Silvio, Tisone, Giuseppe, Romito, Raffaele, Tedeschi, Umberto, Zimmitti, Giuseppe, Aldrighetti, L, Ratti, F, Cillo, U, Ferrero, A, Ettorre, G, Guglielmi, A, Giuliante, F, Calise, F, Dalla Valle, R, Mazzaferro, V, Jovine, E, De Carlis, L, Boggi, U, Gruttadauria, S, Di Benedetto, F, Reggiani, P, Berti, S, Ceccarelli, G, Vincenti, L, Belli, G, Torzilli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Ercolani, G, Boni, L, Maida, P, Griseri, G, Percivale, A, Filauro, M, Guerriero, S, Tisone, G, Romito, R, Tedeschi, U, Zimmitti, G, Aldrighetti, Luca, Ratti, Francesca, Cillo, Umberto, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Guglielmi, Alfredo, Giuliante, Felice, Calise, Fulvio, Dalla Valle, Raffaele, Mazzaferro, Vincenzo, Jovine, Elio, De Carlis, Luciano Gregorio, Boggi, Ugo, Gruttadauria, Salvatore, Di Benedetto, Fabrizio, Reggiani, Paolo, Berti, Stefano, Ceccarelli, Graziano, Vincenti, Leonardo, Belli, Giulio, Torzilli, Guido, Zamboni, Fausto, Coratti, Andrea, Mezzatesta, Pietro, Santambrogio, Roberto, Navarra, Giuseppe, Giuliani, Antonio, Pinna, Antonio Daniele, Parisi, Amilcare, Colledan, Michele, Slim, Abdallah, Antonucci, Adelmo, Grazi, Gian Luca, Frena, Antonio, Sgroi, Giovanni, Brolese, Alberto, Morelli, Luca, Floridi, Antonio, Patriti, Alberto, Veneroni, Luigi, Ercolani, Giorgio, Boni, Luigi, Maida, Pietro, Griseri, Guido, Percivale, Andrea, Filauro, Marco, Guerriero, Silvio, Tisone, Giuseppe, Romito, Raffaele, Tedeschi, Umberto, and Zimmitti, Giuseppe

Abstract

A technical error led to incorrect rendering of the author group in this article. The correct authorship is as follows: Luca Aldrighetti, Francesca Ratti, Umberto Cillo, Alessandro Ferrero, Giuseppe Maria Ettorre, Alfredo Guglielmi, Felice Giuliante, Fulvio Calise on behalf of the Italian Group of Minimally Invasive Liver Surgery (I GO MILS) The collaborators are: Raffaele Dalla Valle, AOU Parma, Parma; Vincenzo Mazzaferro, Istituto Nazionale Tumori, Milano; Elio Jovine, Ospedale Maggiore, Bologna; Luciano Gregorio De Carlis, Ospedale Niguarda Ca’ Granda, Milano; Ugo Boggi, AOU Pisana, Pisa; Salvatore Gruttadauria, ISMETT, Palermo; Fabrizio Di Benedetto, AOU Policlinico di Modena, Modena; Paolo Reggiani, Ospedale Maggiore Policlinico, Milano; Stefano Berti, Ospedale Civile S.Andrea, La Spezia; Graziano Ceccarelli, Ospedale San Donato, Arezzo; Leonardo Vincenti, AOU Consorziale Policlinico, Bari; Giulio Belli, Ospedale SM Loreto Nuovo, Napoli; Guido Torzilli, Istituto Clinico Humanitas, Rozzano; Fausto Zamboni, Ospedale Brotzu, Cagliari; Andrea Coratti, AOU Careggi, Firenze; Pietro Mezzatesta, Casa di Cura La Maddalena, Palermo; Roberto Santambrogio, AO San Paolo, Milano; Giuseppe Navarra, AOU Policlinico G. Martino, Messina; Antonio Giuliani, AO R.N. Cardarelli, Napoli; Antonio Daniele Pinna, Policlinico Sant’Orsola Malpighi, Bologna; Amilcare Parisi, AO Santa Maria di Terni, Terni; Michele Colledan, AO Papa Giovanni XXIII, Bergamo; Abdallah Slim, AO Desio e Vimercate, Vimercate; Adelmo Antonucci, Policlinico di Monza, Monza; Gian Luca Grazi, Istituto Nazionale Tumori Regina Elena, Roma; Antonio Frena, Ospedale Centrale, Bolzano; Giovanni Sgroi, AO Treviglio-Caravaggio, Treviglio; Alberto Brolese, Ospedale S.Chiara, Trento; Luca Morelli, AOU Pisana, Pisa; Antonio Floridi, AO Ospedale Maggiore, Crema; Alberto Patriti, Ospedale San Matteo degli Infermi, Spoleto; Luigi Veneroni, Ospedale Infermi AUSL Romagna, Rimini; Giorgio Ercolani, Ospedale Morgagni Pierantoni, Forl

Published
2018

21. Development of a prognostic score to predict response to Yttrium-90 radioembolization for hepatocellular carcinoma with portal vein invasion

Author

Spreafico, Carlo, primary, Sposito, Carlo, additional, Vaiani, Marta, additional, Cascella, Tommaso, additional, Bhoori, Sherrie, additional, Morosi, Carlo, additional, Lanocita, Rodolfo, additional, Romito, Raffaele, additional, Chiesa, Carlo, additional, Maccauro, Marco, additional, Marchianò, Alfonso, additional, and Mazzaferro, Vincenzo, additional

Published
2018
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22. Glutamine and Alanine Kinetics in Humans: Role of the Liver

Author

BATTEZZATI, ALBERTO, FATTORINI, ANNALISA, CAUMO, ANDREA, REGALIA, ENRICO, ROMITO, RAFFAELE, COPPA, JORGELINA, MATTHEWS, DWIGHT E., MAZZAFERRO, VINCENZO, and LUZI, LIVIO

Subjects
Glutamine metabolism -- Physiological aspects, Liver -- Transplantation, Diabetes -- Research, Health
Abstract

The liver is considered the major site of glutamine and alanine (but not leucine) handling. To directly test this hypothesis in humans, we measured glutamine and alanine kinetics during the [...]

Published
2000

23. Non-Hepatic Glucose Production In Humans

Author

BATTEZZATI, ALBERTO, FATTORINI, ANNALISA, CAUMO, ANDREA, COPPA, JORGELINA, ROMITO, RAFFAELE, REGALIA, ENRICO, MATTHEWS, DWIGHT E, MAZZAFERRO, VINCENZO, and LUZI, LIVIO

Subjects
Diabetes -- Research, Health
Abstract

To assess whether humans can produce significant amounts of glucose independently from the liver, we measured the conversion of gluconeogenic substrates when the liver is physically absent, i.e. during the [...]

Published
1999

24. Intrahepatic Flow Redistribution in Patients Treated with Radioembolization

Author

Spreafico, Carlo, primary, Morosi, Carlo, additional, Maccauro, Marco, additional, Romito, Raffaele, additional, Lanocita, Rodolfo, additional, Civelli, Enrico M., additional, Sposito, Carlo, additional, Bhoori, Sherrie, additional, Chiesa, Carlo, additional, Frigerio, Laura F., additional, Lorenzoni, Alice, additional, Cascella, Tommaso, additional, Marchianò, Alfonso, additional, and Mazzaferro, Vincenzo, additional

Published
2014
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25. Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation

Author

Mazzaferro, Vincenzo, primary, Battiston, Carlo, additional, Perrone, Stefano, additional, Pulvirenti, Andrea, additional, Regalia, Enrico, additional, Romito, Raffaele, additional, Sarli, Dario, additional, Schiavo, Marcello, additional, Garbagnati, Francesco, additional, Marchianò, Alfonso, additional, Spreafico, Carlo, additional, Camerini, Tiziana, additional, Mariani, Luigi, additional, Miceli, Rosalba, additional, and Andreola, Salvatore, additional

Published
2004
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26. Assessment of insulin sensitivity based on a fasting blood sample in men with liver cirrhosis before and after liver transplantation1

Author

Perseghin, Gianluca, primary, Caumo, Andrea, additional, Mazzaferro, Vincenzo, additional, Pulvirenti, Andrea, additional, Piceni Sereni, Lucia, additional, Romito, Raffaele, additional, Lattuada, Guido, additional, Coppa, Jorgelina, additional, Costantino, Federica, additional, Regalia, Enrico, additional, and Luzi, Livio, additional

Published
2003
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27. Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: Effect of liver transplantation

Author

Perseghin, Gianluca, primary, Mazzaferro, Vincenzo, additional, Sereni, Lucia Piceni, additional, Regalia, Enrico, additional, Benedini, Stefano, additional, Bazzigaluppi, Elena, additional, Pulvirenti, Andrea, additional, Leão, Adriana Antonio Silva, additional, Calori, Giliola, additional, Romito, Raffaele, additional, Baratti, Dario, additional, and Luzi, Livio, additional

Published
2000
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28. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy.

Author

de'Angelis N, Catena F, Memeo R, Coccolini F, Martínez-Pérez A, Romeo OM, De Simone B, Di Saverio S, Brustia R, Rhaiem R, Piardi T, Conticchio M, Marchegiani F, Beghdadi N, Abu-Zidan FM, Alikhanov R, Allard MA, Allievi N, Amaddeo G, Ansaloni L, Andersson R, Andolfi E, Azfar M, Bala M, Benkabbou A, Ben-Ishay O, Bianchi G, Biffl WL, Brunetti F, Carra MC, Casanova D, Celentano V, Ceresoli M, Chiara O, Cimbanassi S, Bini R, Coimbra R, Luigi de'Angelis G, Decembrino F, De Palma A, de Reuver PR, Domingo C, Cotsoglou C, Ferrero A, Fraga GP, Gaiani F, Gheza F, Gurrado A, Harrison E, Henriquez A, Hofmeyr S, Iadarola R, Kashuk JL, Kianmanesh R, Kirkpatrick AW, Kluger Y, Landi F, Langella S, Lapointe R, Le Roy B, Luciani A, Machado F, Maggi U, Maier RV, Mefire AC, Hiramatsu K, Ordoñez C, Patrizi F, Planells M, Peitzman AB, Pekolj J, Perdigao F, Pereira BM, Pessaux P, Pisano M, Puyana JC, Rizoli S, Portigliotti L, Romito R, Sakakushev B, Sanei B, Scatton O, Serradilla-Martin M, Schneck AS, Sissoko ML, Sobhani I, Ten Broek RP, Testini M, Valinas R, Veloudis G, Vitali GC, Weber D, Zorcolo L, Giuliante F, Gavriilidis P, Fuks D, and Sommacale D

Subjects
Humans, Iatrogenic Disease, Intraoperative Period, Quality of Life, Bile Ducts injuries, Cholecystectomy adverse effects
Abstract

Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.

Published
2021
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29. Genistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation.

Author

Farruggio S, Cocomazzi G, Marotta P, Romito R, Surico D, Calamita G, Bellan M, Pirisi M, and Grossini E

Subjects
AMP-Activated Protein Kinase Kinases, Cell Line, Hepatocytes metabolism, Humans, Membrane Potential, Mitochondrial drug effects, Oxidative Stress drug effects, Phytoestrogens pharmacology, Protein Kinases metabolism, Proto-Oncogene Proteins c-akt metabolism, Reactive Oxygen Species metabolism, Receptors, Estrogen antagonists & inhibitors, Receptors, G-Protein-Coupled antagonists & inhibitors, Toll-Like Receptor 4 metabolism, Triglycerides metabolism, Cell Survival drug effects, Estradiol pharmacology, Genistein pharmacology, Hepatocytes drug effects, Inflammasomes metabolism, Mitochondria metabolism, Non-alcoholic Fatty Liver Disease metabolism
Abstract

Background/aims: Oxidative stress and mitochondria dysfunction could be involved in the onset of non-alcoholic fatty liver disease (NAFLD) and in its progression to non-alcoholic steatohepatitis (NASH). Estrogens/phytoestrogens could counteract liver fat deposition with beneficial effects against NAFLD by unclear mechanisms. We aimed to analyze the protective effects elicited by genistein/estradiol in hepatocytes cultured in NAFLD-like medium on cell viability, triglycerides accumulation, mitochondrial function and oxidative stress and the role of NLRP3 inflammasome, toll like receptors 4 (TLR4), Akt and 5' AMP-activated protein kinase (AMPK)α1/2., Methods: Human primary hepatocytes/hepatoma cell line (Huh7.5 cells) were incubated with a 2 mM mixture of oleate/palmitate in presence/absence of genistein/17β-estradiol. In some experiments, Huh7.5 cells were exposed to various inhibitors of the above pathways and estrogenic receptors (ERs) and G protein-coupled estrogen receptor (GPER) blockers, before genistein/17β-estradiol. Cell viability, mitochondrial membrane potential, reactive oxygen species and triglycerides content were examined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT), 5,51,6,61-tetrachloro-1,11,3,31 tetraethylbenzimidazolyl carbocyanine iodide (JC-1), 2,7-dichlorodihydrofluorescein diacetate (H2DCFDA) and the Triglyceride Colorimetric Assay. The expression/activation of kinases was analyzed by means of Western blot., Results: Genistein/17β-estradiol protected hepatocytes against NAFLD-like medium, by preventing the loss of cell viability and mitochondrial function, triglycerides accumulation and peroxidation. The blocking of kinases, ERs and GPER was able to reduce the above effects, which were potentiated by NLRP3 inflammasome., Conclusion: Our findings suggest novel mechanisms underlying the protective effects elicited by phytoestrogens/estrogens against NAFLD/NASH and open novel therapeutic perspectives in the management of NAFLD in postmenopausal women., Competing Interests: The authors have no conflicts of interest to declare., (© Copyright by the Author(s). Published by Cell Physiol Biochem Press.)

Published
2020
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30. Fibroblastic reticular cell tumor of the spleen: report of a case and review of the entity.

Author

Martel M, Sarli D, Colecchia M, Coppa J, Romito R, Schiavo M, Mazzaferro V, and Rosai J

Subjects
Female, Humans, Middle Aged, Sarcoma surgery, Spleen diagnostic imaging, Splenic Neoplasms surgery, Stromal Cells pathology, Tomography, X-Ray Computed, Fibroblasts pathology, Sarcoma secondary, Splenic Neoplasms pathology
Abstract

Fibroblastic reticulum cells (FBRCs) are stromal support cells located in the parafollicular area and deep cortex of lymph nodes and in the extrafollicular areas of the spleen and tonsils. We report a case of malignant FBRC tumor of the spleen occurring in a 61-year-old woman. Two years after splenectomy, multiple hepatic lesions were found, which were resected. Histologically, the tumor showed similar morphological features in the spleen as in the liver metastases. There was a whorled pattern of oval and spindle cells in a collagenized background admixed with an inflammatory cell infiltrate composed of lymphocytes and plasma cells. The tumor cells were positive for common muscle actin, smooth muscle actin, and focally for CD68. In situ hybridization for Epstein Barr virus was negative. To the best of our knowledge, this is the first report of malignant FBRC tumor arising in the spleen. The differential diagnosis of splenic tumors with inflammatory pseudotumor-like features is discussed.

Published
2003
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