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505 results on '"Romiti, Ricardo"'

1. Treatment of Psoriasis Patients with Latent Tuberculosis Using IL-17 and IL-23 Inhibitors: A Retrospective, Multinational, Multicentre Study

Author

Torres, Tiago, Chiricozzi, Andrea, Puig, Luis, Lé, Ana Maria, Marzano, Angelo Valerio, Dapavo, Paolo, Dauden, Esteban, Carrascosa, Jόse-Manuel, Lazaridou, Elizabeth, Duarte, Gleison, Carvalho, André V. E., Romiti, Ricardo, Rompoti, Natalia, Teixeira, Laetitia, Abreu, Miguel, Ippoliti, Elena, Maronese, Carlo Alberto, Llamas-Velasco, Mar, Vilarrasa, Eva, del Alcázar, Elena, Daponte, Athina-Ioanna, Papoutsaki, Marina, Carugno, Andrea, Bellinato, Francesco, and Gisondi, Paolo

Published
2024
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2. The Hair and Scalp in Systemic Infectious Disease

Author

Trüeb, Ralph M., Gavazzoni Dias, Maria Fernanda Reis, Dutra Rezende, Hudson, de la Cruz Vargas Vilte, Remberto Mauricio, Romiti, Ricardo, Trüeb, Ralph M., editor, Dutra Rezende, Hudson, editor, and Gavazzoni Dias, Maria Fernanda Reis, editor

Published
2023
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4. An update of a cost-effectiveness per response of adalimumab, etanercept, guselcumab, infliximab, ixekizumab, secukinumab and ustekinumab for treatment of moderate to severe plaque psoriasis from the perspective of the Brazilian Supplementary Health System /Atualizacao do custo-efetividade por resposta de adalimumabe, etanercepte, guselcumabe, infliximabe, ixequizumabe, secuquinumabe e ustequinumabe no tratamento de psoriase em placas moderada a grave sob a perspectiva do Sistema de Saude Suplementar brasileiro

Author

von Reininghaus, Alexander Bengt, Gomes, Rafael Tomaz, Pires, Bernardo Salustio, Bianco, Juares, Picoli, Renato, Santos, Henrique, Duarte, Gleison Vieira, Romiti, Ricardo, and de Carvalho, Andre Vicente Estede

Published
2022
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8. Factors associated with adverse COVID-19 outcomes in patients with psoriasis—insights from a global registry–based study

Author

Shah, Aadarsh, Barea, Alberto, Romero-Maté, Alberto, Singapore, Alekya, Paolino, Alexandra, Mwale, Alice, Morales Callaghan, Ana Maria, Martinez, Ana, DeCrescenzo, Andrew, Pink, Andrew E., Jones, Ann, Sergeant, Ann, Essex, Annette, Bewley, Anthony, Makrygeorgou, Areti, van Huizen, Astrid, Pérez-Suárez, Beatriz, Farida, Benhadou, Claréus, Birgitta Wilson, Prims, Carla Tubau, Davis, Carrie, Quinlan, Catherine, Maybury, Catriona, Cesar, Gonzalez A., Barclay, Charlotte, Greco, Claudio, Brassard, Danielle, Cummings, Deanna, Kolli, Deepti, Descamps, Vincent, Genao, Diana Ruiz, Carras, Efrossini, Hawryluk, Elena, Martínez-García, Eliseo, Klujszo, Elzbieta, Dwyer, Emily, Toni, Emmanuel, Sonkoly, Enikö, Loayza, Enrique, Daudén, Esteban, Valenzuela, Fernando, Popov, Georgi, King, Georgie, Celine, Girard, Aparicio, Gloria, Johnston, Graham A., Cardozo, Gustavo Anibal, Pearson, Ian, Yanguas, Ignacio, Weisman, Jamie, Carolan, Jennifer E., Hughes, Jenny, Ortiz-Salvador, Jose-Maria, Carrascosa, Jose-Manuel, Schwartz, Joseph J., Jackson, Karina, Kerisit, Kathryn G., Wu, Keith, Asfour, Leila, de Graaf, Leontien, Lesort, Cécile, Meuleman, Lieve, Eidsmo, Liv, Skov, Lone, Gribben, Lorraine, Rustin, Malcolm, Velasco, Manel, Panchal, Manisha, Lakhan, Manpreet, Franco, Manuel D., Svensson, Marie-Louise, Vandaele, Mark, Marovt, Maruska, Zargari, Omid, De Caso, Pablo, Varela, Paulo, Jenkin, Peter, Phan, Céline, Hampton, Philip, Goldsmith, Portia, Bak, Rachel, Speeckaert, Reinhart, Romiti, Ricardo, Woolf, Richard, Mercado-Seda, Rogelio, Khatun, Rohima, Ceovic, Romana, Taberner, Rosa, Cohen, Russell W., Stefanescu, Simina, Kirk, Sarah, Reeken, Saskia, Ayob, Shanti, Pérez-Barrio, Silvia, Piaserico, Stefano, Hoey, Susannah, Torres, Tiago, Talme, Toomas, Desai, Trupti V., van Geest, Adrienne J., King, Victoria, Di Lernia, Vito, Koreja, Zahira, Hasab, Vito Zeeshaan, Mahil, Satveer K., Dand, Nick, Mason, Kayleigh J., Yiu, Zenas Z.N., Tsakok, Teresa, Meynell, Freya, Coker, Bola, McAteer, Helen, Moorhead, Lucy, Mackenzie, Teena, Rossi, Maria Teresa, Rivera, Raquel, Mahe, Emmanuel, Carugno, Andrea, Magnano, Michela, Rech, Giulia, Balogh, Esther A., Feldman, Steven R., De La Cruz, Claudia, Choon, Siew Eng, Naldi, Luigi, Lambert, Jo, Spuls, Phyllis, Jullien, Denis, Bachelez, Hervé, McMahon, Devon E., Freeman, Esther E., Gisondi, Paolo, Puig, Luis, Warren, Richard B., Di Meglio, Paola, Langan, Sinéad M., Capon, Francesca, Griffiths, Christopher E.M., Barker, Jonathan N., and Smith, Catherine H.

Published
2021
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11. Global Comparison of COVID-19 Vaccination Rates among Psoriasis Patients.

Author

Korouri, Edwin, Jeong, Charlotte, Peterson, Hannah, Valenzuela, Fernando, Romiti, Ricardo, Didaskalu, Johannes A., Egeberg, Alexander, Oon, Hazel H., Maul, Lara Valeska, Kingston, Paige, Lee, Kathryn, Huang, Margaret Y., Yee, Danielle, Artiga, Kevin, Aguero, Rosario, Maul, Julia-Tatjana, and Armstrong, April W.

Subjects
COVID-19 vaccines, COVID-19 pandemic, PSORIASIS, COVID-19, CROSS-sectional method
Abstract

(1) Background: The purpose of this study is to compare the rate of COVID-19 vaccination among psoriasis patients internationally and to correlate it with their treatment regimens. (2) Methods: We conducted a cross-sectional study from January 2021 to October 2022 among adults in the United States (US), Chile, China, Switzerland, and Singapore using the Global Healthcare Study on Psoriasis survey. (3) Results: A total of 310 psoriasis patients in the US (98), Chile (32), China (80), Switzerland (39), and Singapore (61) were surveyed. Of these, 248 patients (80.0%) were vaccinated at least once for COVID-19 (Chile: 100%, Singapore: 100%, US: 93.9%, Switzerland: 69.2%, China: 45.0%). Compared with other countries, patients in China were 89% less likely to report at least one COVID-19 vaccination (1 − 0.11 = 0.89; OR 0.11; 95% CI: 0.03–0.48), and patients in Switzerland were 80% less likely (1 − 0.20 = 0.80; OR 0.20; 95% CI: 0.05–0.79). Compared with patients on biologics, patients on topicals were 10.9 (95% CI: 2.1–56.6) times more likely to report at least one COVID-19 vaccination, and patients on oral systemics were 7.2 times more likely (95% CI: 1.6–31.6). (4) Conclusions: Country of residence and treatment regimen are associated with different COVID-19 vaccination rates in psoriasis patients. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The epidemiology of atopic dermatitis and psoriasis in the indigenous people of Brazil.

Author

Andrade, Débora D. B. C., Nzundu, Reagan, Rodrigues, Rodolfo R. D., Romiti, Ricardo, Santana, Yago R. T., Kurizky, Patrícia S., de Lima, Ana P. R., Carvalho, André, Ashcroft, Darren M., Gomes, Ciro M., and Griffiths, Christopher E. M.

Subjects
INDIGENOUS peoples of South America, NOSOLOGY, CITY dwellers, SPECIAL districts, INFANT mortality
Abstract

This article discusses the prevalence of atopic dermatitis (AD) and psoriasis among indigenous people in Brazil. The researchers accessed a Brazilian national database to gather information on AD and psoriasis diagnoses between 2010 and 2022. They found varying rates of AD and psoriasis across different regions of Brazil. The study highlights the importance of understanding the epidemiology of these skin conditions in indigenous populations for effective healthcare planning and interventions. The study found that the prevalence of AD and psoriasis is lower among indigenous populations compared to urban populations, particularly in remote regions like the Yanomami territory. However, it is important to note that AD and psoriasis can still occur in indigenous communities, especially those located near or within urban areas. [Extracted from the article]

Published
2024
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13. Correlation between Dermatology Life Quality Index and Psoriasis Area and Severity Index in Patients with Psoriasis: A Cross-sectional Global Healthcare Study on Psoriasis

Author

Maul, Julia-Tatjana, primary, Maul, Lara W., additional, Didaskalu, Johannes A., additional, Valenzuela, Fernando, additional, Romiti, Ricardo, additional, Peterson, Hannah, additional, Korouri, Edwin, additional, Novoa, Farah, additional, Oon, Hazel H., additional, Zheng, Min, additional, Wu, Jashin J., additional, Thyssen, Jacob P., additional, Egeberg, Alexander, additional, Armstrong, April W., additional, and Nielsen, Mia-Louise, additional

Published
2024
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15. Infections in the era of immunobiologicals

Author

Romiti, Ricardo, primary, Hirayama, André Luís da Silva, additional, Porro, Adriana Maria, additional, Gonçalves, Heitor de Sá, additional, Miot, Luciane Donida Bartoli, additional, Durães, Sandra Maria Barbosa, additional, and Marques, Silvio Alencar, additional

Published
2024
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16. Psoriasis in Latin America

Author

Chouela, Edgardo, Amaya, Mario, Londoño, Angela, Romiti, Ricardo, Valenzuela, Fernando, Duarte, Artur A., Perez Alfonzo, Ricardo, and Borlenghi, Cecilia

Subjects
Psoriasis, epidemiology, adherence, survival, treatment, Latin America
Abstract

During the last few decades, management of psoriasis has changed worldwide, owing to a better understanding of its pathophysiology and the introduction of new treatments. As experts in the field of dermatology, specialists from Latin America collaborated to develop this review and further provide an update on the current state of psoriasis management in Latin America. With the goal of summarizing the latest information on psoriasis in most countries in Latin America, we conducted a literature search to obtain relevant articles published in the medical/scientific literature in Latin American countries over the last 10 years; in addition, we completed a questionnaire comprised of 20 questions on important issues related to psoriasis. The aim of this final document isto help improve understanding and management of the disease and to help patients gain better access to new approaches and medical solutions.

Published
2016

17. Correlation between Dermatology Life Quality Index and Psoriasis Area and Severity Index in Patients with Psoriasis:A Cross-sectional Global Healthcare Study on Psoriasis

Author

Maul, Julia-Tatjana, Maul, Lara V., Didaskalu, Johannes A., Valenzuela, Fernando, Romiti, Ricardo, Peterson, Hannah, Korouri, Edwin, Novoa, Farah, Oon, Hazel H., Zheng, Min, Wu, Jashin J., Thyssen, Jacob P., Egeberg, Alexander, Armstrong, April W., Nielsen, Mia-Louise, Maul, Julia-Tatjana, Maul, Lara V., Didaskalu, Johannes A., Valenzuela, Fernando, Romiti, Ricardo, Peterson, Hannah, Korouri, Edwin, Novoa, Farah, Oon, Hazel H., Zheng, Min, Wu, Jashin J., Thyssen, Jacob P., Egeberg, Alexander, Armstrong, April W., and Nielsen, Mia-Louise

Abstract

Quality of life impairment in dermatology patients and severity of psoriasis are quantified by the Dermatology Life Quality Index (DLQI) and the Psoriasis Area and Severity Index (PASI), respectively. The aim of this study is to compare the correlation between PASI and DLQI in patients from different geographical areas and to identify predictors of high DLQI across geographical regions. Correlations between PASI and DLQI were evaluated using Spearman’s rank correlation tests and quantile regression. The study included 1,158 patients with psoriasis, with a median (interquartile range) PASI and DLQI of 6.0 (3.0–12.0) and 8.0 (4.0–15.0), respectively. Correlations were demonstrated between PASI and DLQI, both overall and stratified by geographical region. Quantile (median) regression yielded coefficients of 0.75 (95% confidence interval (95% CI) 0.62, 0.88) for Switzerland, 0.50 (95% CI 0.42, 0.58) for Latin America, 0.34 (95% CI 0.16, 0.51) for Asia, and 0.31 (95% CI 0.08, 0.53) for the USA. Current age, age at diagnosis, sex, body mass index, and psoriasis arthritis affected DLQI in Latin America, while education had an impact among patients treated in Switzerland. Few countries were included within each continent; hence, more data from different countries are necessary for generalizability. The study showed correlations between PASI and DLQI among patients in all included geographical regions. The patients’ characteristics affecting DLQI vary worldwide.

Published
2024

18. Síndrome de Graham-Little-Piccardi-Lassueur: variante disseminada de líquen plano folicular

Author

Kakizaki, Priscila, Donati, Aline, Valente, Neusa Yuriko Sakai, and Romiti, Ricardo

Subjects
Alopecia, Hypotrichosis, Lichen planus
Abstract

Graham-Little-Piccardi-Lassueur syndrome is a rare lichenoid dermatosis. It is characterized by the triad of scarring alopecia of the scalp, alopecia of the axilla and or groin, and keratotic follicular papules of the body. The present paper reports on two cases affecting young women. Histopathological findings suggest the disorder represents a generalized form of lichen planus follicularis.

Published
2015

19. International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis From the International Psoriasis Council.

Author

Choon, Siew Eng, van de Kerkhof, Peter, Gudjonsson, Johann E., de la Cruz, Claudia, Barker, Jonathan, Morita, Akimichi, Romiti, Ricardo, Affandi, Azura Mohd, Asawanonda, Pravit, Burden, Arthur David, Gonzalez, César, Marrakchi, Slaheddine, Mowla, Mohammad Rafiqul, Okubo, Yukari, Oon, Hazel H., Terui, Tadashi, Tsai, Tsen-Fang, Callis-Duffin, Kristina, Fujita, Hideki, and Jo, Seong Jin

Published
2024
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30. Proceedings of the Ninth World Congress for Hair Research (2015)

Author

Barbosa, Victoria H., Bergfeld, Wilma F., Betz, Regina C., Blume-Peytavi, Ulrike, Botchkarev, Vladimir, Callender, Valerie D., Cappetta, María E., Christiano, Angela M., Cotsarelis, George, Dawson, Thomas L., Jr., Doche, Isabella, Dyer, Jolon, Farjo, Nilofer P., Fried, Richard G., Gilhar, Amos, Goldberg, Lynne J., Gray, John, Higgins, Claire A., Holland, Mark, Hordinsky, Maria K., Horsley, Valerie, Huh, Chang-Hun, King, Lloyd E., Mackay-Wiggan, Julian, McMichael, Amy, Mikkola, Marja L., Millar, Sarah E., Mirmirani, Paradi, Ohyama, Manabu, Olsen, Elise A., Paus, Ralf, Romiti, Ricardo, Rose, Paul T., Sim, Woo-Young, Sinclair, Rodney, Shapiro, Jerry, Tosti, Antonella, Tsuboi, Ryoji, Tsuji, Takashi, Vogt, Annika, Washenik, Ken, Westgate, Gillian E., and Zlotogorski, Abraham

Published
2017
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31. Correlation between DLQI and PASI in patients with psoriasis - a cross-sectional Global Healthcare Study on Psoriasis (GHSP)

Author

Nielsen, Mia-Louise, primary, Maul, Julia-Tatjana, primary, Valeska Maul-Duwendag, Lara, primary, Johannes, Didaskalu, primary, Valenzuela, Fernando, primary, Romiti, Ricardo, primary, Peterson, Hannah, primary, Korouri, Edwin, primary, novoa, farah, primary, H. Oon, Hazel, primary, Zheng, Min, primary, J. Wu, Jashin, primary, Pontoppidan Thyssen, Jacob, primary, Egeberg, Alexander, primary, and W. Armstrong, April, primary

Published
2023
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32. Psoriasis And Mental Health Comorbidities: A Multinational Analysis Using the Global Healthcare Study on Psoriasis (GHSP)

Author

Peterson, Hannah, primary, Korouri, Edwin, primary, Kingston, Paige, primary, kathryn.lee, kathryn.lee, primary, Y. Huang, Margaret, primary, Yee, Danielle, primary, Aguero, Rosario, primary, Artiga, Kevin, primary, Valenzuela, Fernando, primary, Romiti, Ricardo, primary, Johannes, Didaskalu, primary, Egeberg, Alexander, primary, H. Oon, Hazel, primary, Maul, Julia-Tatjana, primary, and W. Armstrong, April, primary

Published
2023
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34. Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study

Author

Verdier, Mônica, Anuardo, Pedro, Gormezano, Natali Weniger Spelling, Romiti, Ricardo, Campos, Lucia Maria Arruda, Aikawa, Nadia Emi, Pereira, Rosa Maria Rodrigues, Terreri, Maria Teresa, Magalhães, Claudia Saad, Ferreira, Juliana C. O. A., Silva, Marco Felipe Castro, Ferriani, Mariana, Sakamoto, Ana Paula, Ferriani, Virginia Paes Leme, Centeville, Maraísa, Sato, Juliana, Santos, Maria Carolina, Bonfá, Eloisa, and Silva, Clovis Artur

Published
2019
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37. Recommendations on the use of biosimilars by the Brazilian Society of Rheumatology, Brazilian Society of Dermatology, Brazilian Federation of Gastroenterology and Brazilian Study Group on Inflammatory Bowel Disease—Focus on clinical evaluation of monoclonal antibodies and fusion proteins used in the treatment of autoimmune diseases

Author

Azevedo, Valderílio Feijó, de Souza Meirelles, Eduardo, Kochen, Jussara de Almeida Lima, Medeiros, Ana Cristina, Miszputen, Sender J., Teixeira, Fábio Vieira, Damião, Adérson Osmar Mourão Cintra, Kotze, Paulo Gustavo, Romiti, Ricardo, Arnone, Marcelo, Ferreira Magalhães, Renata, Maia, Cláudia Pires Amaral, and de Carvalho, André Vicente E.

Published
2015
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38. Access to psoriasis treatment in Brazil and Chile: A cross-sectional multi-centre `Global Healthcare Study on Psoriasis

Author

Maul, Julia-Tatjana, primary, Fröhlich, Fabienne, additional, Maul, Lara Valeska, additional, Stunnenberg, Rieka, additional, Valenzuela, Fernando, additional, De La Cruz, Claudia, additional, Vera-Kellet, Cristián, additional, Armijo, Daniela, additional, Cesar, Wagner G, additional, Carvalho, Andre, additional, Didaskalu, Johannes Alexander, additional, Graf, Nicole, additional, Egeberg, Alexander, additional, Wu, Jashin J, additional, Thyssen, Jacob P, additional, Romiti, Ricardo, additional, and Griffiths, Christopher E M, additional

Published
2023
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39. Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis

Author

Valenzuela, Fernando, primary, De La Cruz, Claudia, additional, Lecaros, Cristóbal, additional, Fernández, Javier, additional, Hevia, Gonzalo, additional, Maul, Lara Valeska, additional, Thyssen, Jacob P., additional, Vera-Kellet, Cristián, additional, Egeberg, Alexander, additional, Armijo, Daniela, additional, Pizarro, Cristian, additional, Riveros, Tatiana, additional, Correa, Hernán, additional, Guglielmetti, Antonio, additional, Didaskalu, Johannes A., additional, Wu, Jashin J., additional, Griffiths, Christopher E. M., additional, Romiti, Ricardo, additional, and Maul, Julia-Tatjana, additional

Published
2022
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43. Diversity in the clinical presentation of generalized pustular psoriasis (GPP): A series of case vignettes from around the world.

Author

Choon, Siew Eng, Elewski, Boni E., Fujita, Hideki, Geng, Songmei, van de Kerkhof, Peter, Mburu, Sicily, Puig, Lluís, Romiti, Ricardo, and Venturini, Marina

Subjects
SYMPTOMS, PSORIASIS, VIGNETTES
Abstract

A key principle of clinical studies and case reports is that they should reflect the demographics and epidemiology of the patient population concerned. Here, we have compiled a diverse group of clinical cases of generalized pustular psoriasis (GPP) to showcase the differences in GPP presentation in patients worldwide. We attempt to capture the broad spectrum of clinical presentations of GPP and showcase the diversity of the patient population. The patients included in this series are diverse in age, genetic background, skin phototype and medical history. Moreover, they present with a variety of clinical courses of GPP and different degrees of systemic involvement, and experience flares triggered by different inciting factors. The key learnings from this case series may support physicians in identifying and managing patients with this rare and multifaceted disease that can affect patients both physically and psychologically. [ABSTRACT FROM AUTHOR]

Published
2023
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49. International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

Author

van Huizen, Astrid M., Menting, Stef P., Gyulai, Rolland, Iversen, Lars, van der Kraaij, Gayle E., Middelkamp-Hup, Maritza A., Warren, Richard B., Spuls, Phyllis I., Schejtman, Adrián A., Egeberg, Alexander, Firooz, Alireza, Kumar, Alur S., Oakley, Amanda, Foulkes, Amy, Ramos, Andrea Machado Coelho, Fougerousse, Anne-Claire, Čarija, Antoanela, Akman-Karakaş, Ayse, Horváth, Barbara, Fábos, Béata, Matlock, Benjamin Hidalgo, Claréus, Birgitta Wilson, Castro, Carla, Ferrándiz, Carlos, Correa, Carolina Cortés, Marchesi, Carolina, Goujon, Catherine, Gonzalez, Cesar, Maldonado-García, César, Hong, Chih-ho, Griffiths, Christopher E.M., Vestergaard, Christian, Echeverría, Christina Mariela, de la Cruz, Claudia, Conrad, Curdin, Törőcsik, Dániel, Drvar, Daniela Ledić, Balak, Deepak, Jullien, Denis, Appelen, Diebrecht, Kim, Dong Hyun, de Jong, Elke M.G.J., El Gamal, Emad, Laffitte, Emmanuel, Mahé, Emmanuel, Sonkoly, Enikö, Colombo, Erika Páez, Vilarrasa, Eva, Willaert, Fabienne, Novoa, Farah D., Handjani, Farhad, Valenzuela, Fernando, Vílchez-Márquez, Francisco, Gonzalez, Gabriela Otero, Krisztián, Gáspár, Damiani, Giovanni, Krnjević-Pezić, Gordana, Pellerano, Graciela, Carretero, Gregorio, Hunter, Hamish J. A., Riad, Hassan, Oon, Hazel H., Boonen, Hugo P.J., Moussa, Iftin Osman, García-Doval, Ignacio, Csányi, Ildíko, Brajac, Ines, Turchin, Irina, Grozdev, Ivan, Weinberg, Jeffrey M., Nicolopoulos, Jenny, Wells, Jillian, Lambert, Jo L.W., Ingram, John R., Prinz, Jörg Christoph, de Souza Sittart, José Alexandre, Sanchez, Jose Luis, Hsiao, Josephine Pa-Fan, Castro-Ayarza, Juan Raul, Maul, Julia-Tatjana, van den Reek, Juul M.P.A., Trčko, Katarina, Barber, Kirk, Reich, Kristian, Gebauer, Kurt Aaron, Khobzei, Kuzma, Maul, Lara V., Massari, Larisa Prpić, Fardet, Laurence, le Cleach, Laurence, Misery, Laurent, Chandrashekar, Laxmisha, Muresanu, Lidia Irinel, Lecluse, Lidian, Skov, Lone, Frez, Ma. Lorna, Babić, Lucija Tomić, Puig, Lluís, Gomez, Luis Castro, Ramam, M., Dutil, Maha, El-Sayed, Mahira Hamdy, Olszewska, Malgorzata, Schram, Mandy Elvira, Franco, Manuel Dario, Llamas-Velasco, Mar, Gonçalo, Margarida, Velásquez-Lopera, Margarita M., Abad, Maria Eugenia, de Oliveira, Maria de Fátima Santos Paim, Seyger, Marieke M. B., Kaštelan, Marija, Rademaker, Marius, Sikora, Mariusz, Lebwohl, Mark, Wiseman, Marni C., Ferran, Marta, van Doorn, Martijn, Danespazhooh, Maryam, Bylaitė-Bucinskiene, Matilda, Gooderham, Melinda J., Polić, Melita Vukšić, de Rie, Menno A., Zheng, Min, Gómez-Flores, Minerva, Salleras i Redonnet, Montse, Silverberg, Nanette B., Doss, Nejib, Yawalkar, Nikhil, Chosidow, Olivier, Zargari, Omid, de la Cueva, Pablo, Fernandez-Peñas, Pablo, Cárdenas Rojas, Paola J., Gisondi, Paolo, Grewal, Parbeer, Sator, Paul, Luna, Paula Carolina, Félix, Paulo Antonio Oldani, Varela, Paulo, Holló, Péter, Cetkovska, Petra, Calzavara-Pinton, Piergiacomo, Ghislain, Pierre-Dominique, Araujo, Raquel Ruiz, Romiti, Ricardo, Kui, Róbert, Čeović, Romana, Vender, Ronald, Lafuente-Urrez, Rosario Fátima, del-Río, Rubén, Gulin, Sandra J., Handa, Sanjeev, Mahil, Satveer K., Kolalapudi, Seetharam A., Marrón, Servando E., Azimi, Seyyede Zeinab, Janmohamed, Sherief R., da Cruz Costa, Sidney Augusto, Choon, Siew Eng, Urbancek, Slavomir, Ayanlowo, Olusola, Margasin, Susana M., Wong, Tak-Wah, Mälkönen, Tarja, Hurtová, Tatiana, Reciné, Tatiana Riveros, Huldt-Nystrøm, Theis, Torres, Tiago, Liu, Tong-Yun, Leonidze, Tsira, Sharma, Vinod Kumar, Weightman, Warren, Gulliver, Wayne, Veldkamp, Wendelien, Clinical sciences, Gerontology, Surgical clinical sciences, Dermatology, Skin function and permeability, AII - Inflammatory diseases, Graduate School, APH - Quality of Care, APH - Methodology, and APH - Personalized Medicine

Subjects
Adult, Consensus, International eDelphi Study, Patients, Methotrexate Dosing Regimen, Dermatology, THERAPY, Psoriasis/therapy, BRITISH-ASSOCIATION, DOUBLE-BLIND, Folic Acid, Surveys and Questionnaires, MANAGEMENT, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Dermatovenerologija, SYSTEMIC TREATMENT, Humans, Psoriasis, 610 Medicine & health, Child, Methotrexate, methotrexate in psoriasis, Other Research Radboud Institute for Health Sciences [Radboudumc 0], EFFICACY, RANDOMIZED-TRIAL, DERMATOLOGISTS GUIDELINES, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], CHRONIC PLAQUE PSORIASIS, MODERATE, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Dermatovenerology
Abstract

Contains fulltext : 251813.pdf (Publisher’s version ) (Closed access) IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.

Published
2022
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50. Comorbidities in Chilean patients with psoriasis:a Global Healthcare Study on Psoriasis

Author

Valenzuela, Fernando, De La Cruz, Claudia, Lecaros, Cristóbal, Fernández, Javier, Hevia, Gonzalo, Maul, Lara Valeska, Thyssen, Jacob P., Vera-Kellet, Cristián, Egeberg, Alexander, Armijo, Daniela, Pizarro, Cristian, Riveros, Tatiana, Correa, Hernán, Guglielmetti, Antonio, Didaskalu, Johannes A., Wu, Jashin J., Griffiths, Christopher E.M., Romiti, Ricardo, Maul, Julia Tatjana, Valenzuela, Fernando, De La Cruz, Claudia, Lecaros, Cristóbal, Fernández, Javier, Hevia, Gonzalo, Maul, Lara Valeska, Thyssen, Jacob P., Vera-Kellet, Cristián, Egeberg, Alexander, Armijo, Daniela, Pizarro, Cristian, Riveros, Tatiana, Correa, Hernán, Guglielmetti, Antonio, Didaskalu, Johannes A., Wu, Jashin J., Griffiths, Christopher E.M., Romiti, Ricardo, and Maul, Julia Tatjana

Abstract

Background: Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America. Aim: To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis. Methods: This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression. Results: In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis. Conclusions: We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.

Published
2022

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