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1. Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis

Author

Schoepfer, Alain M, Hirano, Ikuo, Coslovsky, Michael, Roumet, Marie C, Zwahlen, Marcel, Kuehni, Claudia E, Hafner, David, Alexander, Jeffrey A, Dellon, Evan S, Gonsalves, Nirmala, Leung, John, Bussmann, Christian, Collins, Margaret H, Newbury, Robert O, Smyrk, Thomas C, Woosley, John T, Yang, Guang-Yu, Romero, Yvonne, Katzka, David A, Furuta, Glenn T, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Spergel, Jonathan M, Falk, Gary W, Meltzer, Brian A, Comer, Gail M, Straumann, Alex, Safroneeva, Ekaterina, Group, International EEsAI Study, Achem, Sami R, Arora, Amindra S, Alpan, Oral, Armstrong, David, Attwood, Stephen E, Butterfield, Joseph H, Crowell, Michael D, DeVault, Kenneth R, Drouin, Eric, Enav, Benjamin, Enders, Felicity T, Fleischer, David E, Foxx-Orenstein, Amy, Francis, Dawn L, Guyatt, Gordon H, Harris, Lucinda A, Kagalwalla, Amir F, Kita, Hirohito, Krishna, Murli, Lee, James J, Lewis, John C, Lim, Kaiser, Locke, G Richard, Murray, Joseph A, Nguyen, Cuong C, Orbelo, Diana M, Pasha, Shabana F, Ramirez, Francisco C, Sheikh, Javed, Umar, Sarah B, Weiler, Catherine R, Wo, John M, Wu, Tsung-Teh, and Yost, Kathleen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Clinical Trials and Supportive Activities, Prevention, Adolescent, Adult, Aged, Anti-Inflammatory Agents, Dose-Response Relationship, Drug, Eosinophilic Esophagitis, Esophagoscopy, Esophagus, Female, Fluticasone, Humans, Male, Middle Aged, Prognosis, Severity of Illness Index, Young Adult, Index, Variability in Endoscopic Assessment, Instrument, International EEsAI Study Group, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsEosinophilic esophagitis (EoE) is assessed endoscopically (endoscopic activity), based on grades of edema, rings, exudates, furrows, and strictures (EREFS). We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of patients with EoE.MethodsFor the development set, 5 gastroenterologists reviewed EREFS findings from 266 adults with EoE and provided endoscopist global assessment scores (EndoGA, scale of 0 to 10); variation (ΔEndoGA) was assessed using linear regression. We evaluated simple scores (features given arbitrary values from 0 to 3) and developed 2 scoring systems (adjusted score range, 0-100). We then fitted our linear regression model with mean EndoGA to data from 146 adults recruited in centers in Switzerland and the United States between April 2011 and December 2012. For the validation set, we collected data from 120 separate adults (recruited in centers in Switzerland and the United States between May 2013 and July 2014), assessing regression coefficient-based scores using Bland-Altman method. We assessed the responsiveness of our scoring systems using data from a randomized trial of patients with EoE given fluticasone (n=16) or placebo (n=8).ResultsThe distribution of EndoGA values differed among endoscopists (mean ΔEndoGA, 2.6±1.8; range 0-6.6). We developed 2 regression-based scoring systems to assess overall and proximal and distal esophageal findings; variation in endoscopic features accounted for more than 90% of the mean EndoGA variation. In the validation group, differences between mean EndoGA and regression-based scores were small (ranging from -4.70 to 2.03), indicating good agreement. In analyses of data from the randomized trial, the baseline to end of study change in patients given fluticasone was a reduction of 24.3 in simple score (reduction of 4.6 in patients given placebo, P=.052); a reduction of 23.5 in regression-based overall score (reduction of 6.56 in patients given placebo, P=.12), and a reduction of 23.8 (reduction of 8.44 in patients given placebo, P=.11).ConclusionAssessments of endoscopic activity in patients with EoE vary among endoscopists. In an analysis of data from a randomized controlled trial, we found that newly developed scoring systems are no better than simple scoring system in detecting changes in endoscopic activity. These results support the use of a simple scoring system in evaluation of endoscopic activity in patients with EoE. clinicaltrials.gov no: NCT00939263 and NCT01386112.

Published
2019

2. Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis

Author

Safroneeva, Ekaterina, Straumann, Alex, Coslovsky, Michael, Zwahlen, Marcel, Kuehni, Claudia E, Panczak, Radoslaw, Haas, Nadine A, Alexander, Jeffrey A, Dellon, Evan S, Gonsalves, Nirmala, Hirano, Ikuo, Leung, John, Bussmann, Christian, Collins, Margaret H, Newbury, Robert O, De Petris, Giovanni, Smyrk, Thomas C, Woosley, John T, Yan, Pu, Yang, Guang-Yu, Romero, Yvonne, Katzka, David A, Furuta, Glenn T, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Spergel, Jonathan M, Schoepfer, Alain M, Group, International Eosinophilic Esophagitis Activity Index Study, Achem, Sami R, Arora, Amindra S, Alpan, Oral, Armstrong, David, Attwood, Stephen E, Butterfield, Joseph H, Crowell, Michael D, DeVault, Kenneth R, Drouin, Eric, Enav, Benjamin, Enders, Felicity T, Fleischer, David E, Foxx-Orenstein, Amy, Francis, Dawn L, Guyatt, Gordon H, Harris, Lucinda A, Kagalwalla, Amir F, Kita, Hirohito, Krishna, Murli, Lee, James J, Lewis, John C, Lim, Kaiser, Locke, G Richard, Murray, Joseph A, Nguyen, Cuong C, Orbelo, Diana M, Pasha, Shabana F, Ramirez, Francisco C, Sheikh, Javed, Umar, Sarah B, Weiler, Catherine R, Wo, John M, Wu, Tsung-Teh, and Yost, Kathleen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Cancer, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Adolescent, Adult, Aged, Aged, 80 and over, Area Under Curve, Biopsy, Eosinophilic Esophagitis, Eosinophils, Esophagoscopy, Female, Humans, Leukocyte Count, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, ROC Curve, Remission Induction, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires, Switzerland, Treatment Outcome, United States, Young Adult, EEsAI, Remission, Endoscopic Grading, Disease Monitoring, International Eosinophilic Esophagitis Activity Index Study Group, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsIt is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission.MethodsBetween April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score

Published
2016

3. Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis

Author

Achem, Sami R., Arora, Amindra S., Alpan, Oral, Armstrong, David, Attwood, Stephen E., Butterfield, Joseph H., Crowell, Michael D., DeVault, Kenneth R., Drouin, Eric, Enav, Benjamin, Enders, Felicity T., Fleischer, David E., Foxx-Orenstein, Amy, Francis, Dawn L., Guyatt, Gordon H., Harris, Lucinda A., Kagalwalla, Amir F., Kita, Hirohito, Krishna, Murli, Lee, James J., Lewis, John C., Lim, Kaiser, Locke, G. Richard, III, Murray, Joseph A., Nguyen, Cuong C., Orbelo, Diana M., Pasha, Shabana F., Ramirez, Francisco C., Sheikh, Javed, Umar, Sarah B., Weiler, Catherine R., Wo, John M., Wu, Tsung-Teh, Yost, Kathleen J., Schoepfer, Alain M., Hirano, Ikuo, Coslovsky, Michael, Roumet, Marie C., Zwahlen, Marcel, Kuehni, Claudia E., Hafner, David, Alexander, Jeffrey A., Dellon, Evan S., Gonsalves, Nirmala, Leung, John, Bussmann, Christian, Collins, Margaret H., Newbury, Robert O., Smyrk, Thomas C., Woosley, John T., Yang, Guang-Yu, Romero, Yvonne, Katzka, David A., Furuta, Glenn T., Gupta, Sandeep K., Aceves, Seema S., Chehade, Mirna, Spergel, Jonathan M., Falk, Gary W., Meltzer, Brian A., Comer, Gail M., Straumann, Alex, and Safroneeva, Ekaterina

Published
2019
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4. Development and Validation of a Symptom-Based Activity Index for Adults With Eosinophilic Esophagitis

Author

Schoepfer, Alain M, Straumann, Alex, Panczak, Radoslaw, Coslovsky, Michael, Kuehni, Claudia E, Maurer, Elisabeth, Haas, Nadine A, Romero, Yvonne, Hirano, Ikuo, Alexander, Jeffrey A, Gonsalves, Nirmala, Furuta, Glenn T, Dellon, Evan S, Leung, John, Collins, Margaret H, Bussmann, Christian, Netzer, Peter, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Moawad, Fouad J, Enders, Felicity T, Yost, Kathleen J, Taft, Tiffany H, Kern, Emily, Zwahlen, Marcel, Safroneeva, Ekaterina, and Group, International Eosinophilic Esophagitis Activity Index Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Food Allergies, Adaptation, Psychological, Adult, Deglutition Disorders, Endoscopy, Gastrointestinal, Eosinophilic Esophagitis, Feeding Behavior, Female, Humans, Linear Models, Male, Reproducibility of Results, Self Report, Severity of Illness Index, Surveys and Questionnaires, Switzerland, United States, Disease Activity Measurement, Esophagus, Patient-Reported Outcome, Marker, International Eosinophilic Esophagitis Activity Index Study Group, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsStandardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patient assessments of disease severity. We also evaluated relationships between patient assessment of disease severity and EoE-associated endoscopic, histologic, and laboratory findings.MethodsWe collected information from 186 patients with EoE in Switzerland and the United States (69.4% male; median age, 43 y) via surveys (n = 135), focus groups (n = 27), and semistructured interviews (n = 24). Items were generated for the instruments to assess biologic activity based on physician input. Linear regression was used to quantify the extent to which variations in patient-reported disease characteristics could account for variations in patient assessment of EoE severity. The PRO instrument was used prospectively in 153 adult patients with EoE (72.5% male; median age, 38 y), and validated in an independent group of 120 patients with EoE (60.8% male; median age, 40.5 y).ResultsSeven PRO factors that are used to assess characteristics of dysphagia, behavioral adaptations to living with dysphagia, and pain while swallowing accounted for 67% of the variation in patient assessment of disease severity. Based on statistical consideration and patient input, a 7-day recall period was selected. Highly active EoE, based on endoscopic and histologic findings, was associated with an increase in patient-assessed disease severity. In the validation study, the mean difference between patient assessment of EoE severity (range, 0-10) and PRO score (range, 0-8.52) was 0.15.ConclusionsWe developed and validated an EoE scoring system based on 7 PRO items that assess symptoms over a 7-day recall period. Clinicaltrials.gov number: NCT00939263.

Published
2014

5. Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis

Author

Achem, Sami R., Arora, Amindra S., Alpan, Oral, Armstrong, David, Attwood, Stephen E., Butterfield, Joseph H., Crowell, Michael D., DeVault, Kenneth R., Drouin, Eric, Enav, Benjamin, Enders, Felicity T., Fleischer, David E., Foxx-Orenstein, Amy, Francis, Dawn L., Guyatt, Gordon H., Harris, Lucinda A., Kagalwalla, Amir F., Kita, Hirohito, Krishna, Murli, Lee, James J., Lewis, John C., Lim, Kaiser, Locke, G. Richard, III, Murray, Joseph A., Nguyen, Cuong C., Orbelo, Diana M., Pasha, Shabana F., Ramirez, Francisco C., Sheikh, Javed, Umar, Sarah B., Weiler, Catherine R., Wo, John M., Wu, Tsung-Teh, Yost, Kathleen J., Safroneeva, Ekaterina, Straumann, Alex, Coslovsky, Michael, Zwahlen, Marcel, Kuehni, Claudia E., Panczak, Radoslaw, Haas, Nadine A., Alexander, Jeffrey A., Dellon, Evan S., Gonsalves, Nirmala, Hirano, Ikuo, Leung, John, Bussmann, Christian, Collins, Margaret H., Newbury, Robert O., De Petris, Giovanni, Smyrk, Thomas C., Woosley, John T., Yan, Pu, Yang, Guang-Yu, Romero, Yvonne, Katzka, David A., Furuta, Glenn T., Gupta, Sandeep K., Aceves, Seema S., Chehade, Mirna, Spergel, Jonathan M., and Schoepfer, Alain M.

Published
2016
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6. Supplementary Table 1 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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7. Supplementary Table 3 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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8. Supplementary Figure 2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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9. Supplementary Figure Legends 1-2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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10. Supplementary Table 2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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11. Data from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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12. Supplementary Figure 1 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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13. Supplementary Table 4 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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15. American Gastroenterological Association Institute Guideline on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions

Author

Adams, Megan A., Dorn, Spencer D., Dudley-Brown, Sharon L., Flamm, Steven L., Gellad, Ziad F., Gruss, Claudia B., Kosinski, Lawrence R., Lim, Joseph K., Romero, Yvonne, Rubenstein, Joel H., Smalley, Walter E., Sultan, Shahnaz, Weinberg, David S., Yang, Yu-Xiao, Brill, Joel, Krishnan, Prashant, and Leontiadis, Grigorios

Published
2015
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17. American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

Author

Adams, Megan A., Dorn, Spencer D., Dudley-Brown, Sharon L., Flamm, Steven L., Gellad, Ziad F., Gruss, Claudia B., Kosinski, Lawrence R., Lim, Joseph K., Romero, Yvonne, Rubenstein, Joel H., Smalley, Walter E., Sultan, Shahnaz, Weinberg, David S., Yang, Yu-Xiao, Vege, Santhi Swaroop, Ziring, Barry, Jain, Rajeev, and Moayyedi, Paul

Published
2015
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18. Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

Author

Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M., Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P., Kovac, Michal, Adams, Claire L., Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, deCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J., Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Bird, Nigel C., Hardie, Laura J., Reid, Brian J., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Casson, Alan G., Fitzgerald, Rebecca, Whiteman, David C., Risch, Harvey A., Levine, David M., Vaughan, Tom L., Verhaar, Auke P., van den Brande, Jan, Toxopeus, Eelke L., Spaander, Manon C., Wijnhoven, Bas P.L., van der Laan, Luc J.W., Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V., O’Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A., Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, and Jankowski, Janusz

Published
2015
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19. Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization

Author

Thrift, Aaron P., Risch, Harvey A., Onstad, Lynn, Shaheen, Nicholas J., Casson, Alan G., Bernstein, Leslie, Corley, Douglas A., Levine, David M., Chow, Wong–Ho, Reid, Brian J., Romero, Yvonne, Hardie, Laura J., Liu, Geoffrey, Wu, Anna H., Bird, Nigel C., Gammon, Marilie D., Ye, Weimin, Whiteman, David C., and Vaughan, Thomas L.

Published
2014
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20. A Combination of Esomeprazole and Aspirin Reduces Tissue Concentrations of Prostaglandin E2 in Patients With Barrett's Esophagus

Author

Falk, Gary W., Buttar, Navtej S., Foster, Nathan R., Ziegler, Katie L. Allen, DeMars, Catherine J., Romero, Yvonne, Marcon, Norman E., Schnell, Thomas, Corley, Douglas A., Sharma, Prateek, Cruz–Correa, Marcia R., Hur, Chin, Fleischer, David E., Chak, Amitabh, DeVault, Kenneth R., Weinberg, David S., Della'Zanna, Gary, Richmond, Ellen, Smyrk, Thomas C., Mandrekar, Sumithra J., and Limburg, Paul J.

Published
2012
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21. Once-Daily Omeprazole/Sodium Bicarbonate Heals Severe Refractory Reflux Esophagitis with Morning or Nighttime Dosing

Author

Orbelo, Diana M., Enders, Felicity T., Romero, Yvonne, Francis, Dawn L., Achem, Sami R., Dabade, Tushar S., Crowell, Michael D., Geno, Debra M., DeJesus, Ramona S., Namasivayam, Vikneswaran, Adamson, Steven C., Arora, Amindra S., Majka, Andrew J., Alexander, Jeffrey A., Murray, Joseph A., Lohse, Matthew, Diehl, Nancy N., Fredericksen, Mary, Jung, Kee Wook, Houston, Margaret S., O’Neil, Angela E., and Katzka, David A.

Published
2015
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22. Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process

Author

Bennett, Cathy, Vakil, Nimish, Bergman, Jacques, Harrison, Rebecca, Odze, Robert, Vieth, Michael, Sanders, Scott, Gay, Laura, Pech, Oliver, Longcroft–Wheaton, Gaius, Romero, Yvonne, Inadomi, John, Tack, Jan, Corley, Douglas A., Manner, Hendrik, Green, Susi, Al Dulaimi, David, Ali, Haythem, Allum, Bill, Anderson, Mark, Curtis, Howard, Falk, Gary, Fennerty, M. Brian, Fullarton, Grant, Krishnadath, Kausilia, Meltzer, Stephen J., Armstrong, David, Ganz, Robert, Cengia, Gianpaolo, Going, James J., Goldblum, John, Gordon, Charles, Grabsch, Heike, Haigh, Chris, Hongo, Michio, Johnston, David, Forbes–Young, Ricky, Kay, Elaine, Kaye, Philip, Lerut, Toni, Lovat, Laurence B., Lundell, Lars, Mairs, Philip, Shimoda, Tadakuza, Spechler, Stuart, Sontag, Stephen, Malfertheiner, Peter, Murray, Iain, Nanji, Manoj, Poller, David, Ragunath, Krish, Regula, Jaroslaw, Cestari, Renzo, Shepherd, Neil, Singh, Rajvinder, Stein, Hubert J., Talley, Nicholas J., Galmiche, Jean–Paul, Tham, Tony C.K., Watson, Peter, Yerian, Lisa, Rugge, Massimo, Rice, Thomas W., Hart, John, Gittens, Stuart, Hewin, David, Hochberger, Juergen, Kahrilas, Peter, Preston, Sean, Sampliner, Richard, Sharma, Prateek, Stuart, Robert, Wang, Kenneth, Waxman, Irving, Abley, Chris, Loft, Duncan, Penman, Ian, Shaheen, Nicholas J., Chak, Amitabh, Davies, Gareth, Dunn, Lorna, Falck–Ytter, Yngve, Decaestecker, John, Bhandari, Pradeep, Ell, Christian, Griffin, S. Michael, Attwood, Stephen, Barr, Hugh, Allen, John, Ferguson, Mark K., Moayyedi, Paul, and Jankowski, Janusz A.Z.

Published
2012
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25. Eosinophilic esophagitis: Updated consensus recommendations for children and adults

Author

Liacouras, Chris A., Furuta, Glenn T., Hirano, Ikuo, Atkins, Dan, Attwood, Stephen E., Bonis, Peter A., Burks, A. Wesley, Chehade, Mirna, Collins, Margaret H., Dellon, Evan S., Dohil, Ranjan, Falk, Gary W., Gonsalves, Nirmala, Gupta, Sandeep K., Katzka, David A., Lucendo, Alfredo J., Markowitz, Jonathan E., Noel, Richard J., Odze, Robert D., Putnam, Philip E., Richter, Joel E., Romero, Yvonne, Ruchelli, Eduardo, Sampson, Hugh A., Schoepfer, Alain, Shaheen, Nicholas J., Sicherer, Scott H., Spechler, Stuart, Spergel, Jonathan M., Straumann, Alex, Wershil, Barry K., Rothenberg, Marc E., and Aceves, Seema S.

Published
2011
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28. Polymorphisms in genes in the androgen pathway and risk of Barrettʼs esophagus and esophageal adenocarcinoma

Author

Ek, Weronica E., Lagergren, Katarina, Cook, Michael, Wu, Anna H., Abnet, Christian C., Levine, David, Chow, Wong-Ho, Bernstein, Leslie, Risch, Harvey A., Shaheen, Nicholas J., Bird, Nigel C., Corley, Douglas A., Hardie, Laura J., Fitzgerald, Rebecca C., Gammon, Marilie D., Romero, Yvonne, Liu, Geoffrey, Ye, Weimin, Vaughan, Thomas L., MacGregor, Stuart, Whiteman, David C., Westberg, Lars, and Lagergren, Jesper

Published
2016
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30. Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

Author

Thrift, Aaron P., Shaheen, Nicholas J., Gammon, Marilie D., Bernstein, Leslie, Reid, Brian J., Onstad, Lynn, Risch, Harvey A., Liu, Geoffrey, Bird, Nigel C., Wu, Anna H., Corley, Douglas A., Romero, Yvonne, Chanock, Stephen J., Chow, Wong-Ho, Casson, Alan G., Levine, David M., Zhang, Rui, Ek, Weronica E., MacGregor, Stuart, Ye, Weimin, Hardie, Laura J., Vaughan, Thomas L., and Whiteman, David C.

Published
2014
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33. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Author

Ong, Jue-Sheng, Dixon-Suen, Suzanne C., Han, Xikun, An, Jiyuan, Liyanage, Upekha, Dusingize, Jean-Cluade, Schumacher, Johannes, Gockel, Ines, Böhmer, Anne, Jankowski, Janusz, Palles, Claire, O’Mara, Tracy, Spurdle, Amanda, Law, Matthew H., Iles, Mark M., Pharoah, Paul, Berchuck, Andrew, Zheng, Wei, Thrift, Aaron P., Olsen, Catherine, Neale, Rachel E., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart, Fitzgerald, Rebecca, Buas, Matt, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Hardie, Laura J., Bird, Nigel C., Reid, Brian J., Chow, Wong-Ho, Risch, Harvey A., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Whiteman, David E., Vaughan, Thomas, Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Noblin, E. S., Northover, C. A. M., Pitts, S. J., Sathirapongsasuti, J. Fah, Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Ong, Jue-Sheng [0000-0002-6062-710X], Dixon-Suen, Suzanne C. [0000-0003-3714-8386], Han, Xikun [0000-0002-3823-7308], Gockel, Ines [0000-0001-7423-713X], Böhmer, Anne [0000-0002-5716-786X], O’Mara, Tracy [0000-0002-5436-3232], Spurdle, Amanda [0000-0003-1337-7897], Law, Matthew H. [0000-0002-4303-8821], Iles, Mark M. [0000-0002-2603-6509], Pharoah, Paul [0000-0001-8494-732X], Zheng, Wei [0000-0003-1226-070X], Thrift, Aaron P. [0000-0002-0084-5308], Olsen, Catherine [0000-0003-4483-1888], Gharahkhani, Puya [0000-0002-4203-5952], Webb, Penelope M. [0000-0003-0733-5930], MacGregor, Stuart [0000-0001-6731-8142], and Apollo - University of Cambridge Repository

Subjects
631/67/68, 45/43, article, 692/699/67/2195, 692/4028/67/2324
Abstract

Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.

Published
2021
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34. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Author

Ong, Jue Sheng, Dixon-Suen, Suzanne C., Han, Xikun, An, Jiyuan, Fitzgerald, Rebecca, Buas, Matt, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Hardie, Laura J., Bird, Nigel C., Reid, Brian J., Chow, Wong Ho, Risch, Harvey A., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Whiteman, David E., Vaughan, Thomas, Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Noblin, E. S., Northover, C. A.M., Pitts, S. J., Sathirapongsasuti, J. Fah, Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Liyanage, Upekha, Dusingize, Jean Cluade, Schumacher, Johannes, Gockel, Ines, Böhmer, Anne, Jankowski, Janusz, Palles, Claire, O’Mara, Tracy, Spurdle, Amanda, Law, Matthew H., Iles, Mark M., Pharoah, Paul, Berchuck, Andrew, Zheng, Wei, Thrift, Aaron P., Olsen, Catherine, Neale, Rachel E., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart, other, and, Ong, Jue Sheng, Dixon-Suen, Suzanne C., Han, Xikun, An, Jiyuan, Fitzgerald, Rebecca, Buas, Matt, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Hardie, Laura J., Bird, Nigel C., Reid, Brian J., Chow, Wong Ho, Risch, Harvey A., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Whiteman, David E., Vaughan, Thomas, Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Noblin, E. S., Northover, C. A.M., Pitts, S. J., Sathirapongsasuti, J. Fah, Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Liyanage, Upekha, Dusingize, Jean Cluade, Schumacher, Johannes, Gockel, Ines, Böhmer, Anne, Jankowski, Janusz, Palles, Claire, O’Mara, Tracy, Spurdle, Amanda, Law, Matthew H., Iles, Mark M., Pharoah, Paul, Berchuck, Andrew, Zheng, Wei, Thrift, Aaron P., Olsen, Catherine, Neale, Rachel E., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart, and other, and

Abstract

Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.

Published
2021

38. The Mayo Dysphagia Questionnaire-30: Documentation of Reliability and Validity of a Tool for Interventional Trials in Adults with Esophageal Disease

Author

McElhiney, Judith, Lohse, Matthew R., Arora, Amindra S., Peloquin, Joanna M., Geno, Debra M., Kuntz, Melissa M., Enders, Felicity B., Fredericksen, Mary, Abdalla, Adil A., Khan, Yulia, Talley, Nicholas J., Diehl, Nancy N., Beebe, Timothy J., Harris, Ann M., Farrugia, Gianrico, Graner, Darlene E., Murray, Joseph A., Locke, III, G. Richard, Grothe, Rayna M., Crowell, Michael D., Francis, Dawn L., Grudell, April M. B., Dabade, Tushar, Ramirez, Angelica, Alkhatib, MhdMaan, Alexander, Jeffrey A., Kimber, Jessica, Prasad, Ganapathy, Zinsmeister, Alan R., and Romero, Yvonne

Published
2010
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39. Integrative post-genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma

Author

Buas, Matthew F., Levine, David M., Makar, Karen W., Utsugi, Heidi, Onstad, Lynn, Li, Xiaohong, Galipeau, Patricia C., Shaheen, Nicholas J., Hardie, Laura J., Romero, Yvonne, Bernstein, Leslie, Gammon, Marilie D., Casson, Alan G., Bird, Nigel C., Risch, Harvey A., Ye, Weimin, Liu, Geoffrey, Corley, Douglas A., Blount, Patricia L., Fitzgerald, Rebecca C., Whiteman, David C., Wu, Anna H., Reid, Brian J., and Vaughan, Thomas L.

Published
2014
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41. Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett’s Esophagus, and Gastroesophageal Reflux

Author

Ek, Weronica E., Levine, David M., D’Amato, Mauro, Pedersen, Nancy L., Magnusson, Patrik K. E., Bresso, Francesca, Onstad, Lynn E., Schmidt, Peter T., Törnblom, Hans, Nordenstedt, Helena, Romero, Yvonne, Chow, Wong-Ho, Murray, Liam J., Gammon, Marilie D., Liu, Geoffrey, Bernstein, Leslie, Casson, Alan G., Risch, Harvey A., Shaheen, Nicholas J., Bird, Nigel C., Reid, Brian J., Corley, Douglas A., Hardie, Laura J., Ye, Weimin, Wu, Anna H., Zucchelli, Marco, Spector, Tim D., Hysi, Pirro, Vaughan, Thomas L., Whiteman, David C., and MacGregor, Stuart

Published
2013
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