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20 results on '"Romefort, Bénédicte"'

3. Incidence, risk factors, and mortality of neonatal and late-onset dilated cardiomyopathy associated with cardiac neonatal lupus

Author

Morel, Nathalie, Lévesque, Kateri, Maltret, Alice, Baron, Gabriel, Hamidou, Mohamed, Orquevaux, Pauline, Piette, Jean-Charles, Barriere, François, Le Bidois, Jérôme, Fermont, Laurent, Fain, Olivier, Theulin, Arnaud, Sassolas, François, Hauet, Quentin, Guettrot-Imbert, Gaëlle, Georgin-Lavialle, Sophie, Deligny, Christophe, Hachulla, Eric, Mouthon, Luc, Le Jeunne, Claire, Ravaud, Philippe, Le Mercier, Delphine, Romefort, Bénédicte, Villain, Elisabeth, Bonnet, Damien, and Costedoat-Chalumeau, Nathalie

Published
2017
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5. Familial Recurrence Patterns in Congenitally Corrected Transposition of the Great Arteries: An International Study

Author

Tortigue, Marine, primary, Nield, Lynne E., additional, Karakachoff, Matilde, additional, McLeod, Christopher J., additional, Belli, Emre, additional, Babu-Narayan, Sonya V., additional, Prigent, Solène, additional, Boet, Angèle, additional, Conway, Miriam, additional, Elder, Robert W., additional, Ladouceur, Magalie, additional, Khairy, Paul, additional, Kowalik, Ewa, additional, Kalfa, David M., additional, Barron, David J., additional, Mussa, Shafi, additional, Hiippala, Anita, additional, Temple, Joel, additional, Abadir, Sylvia, additional, Le Gloan, Laurianne, additional, Lachaud, Matthias, additional, Sanatani, Shubhayan, additional, Thambo, Jean-Benoit, additional, Gronier, Céline Grunenwald, additional, Amedro, Pascal, additional, Vaksmann, Guy, additional, Charbonneau, Anne, additional, Koutbi, Linda, additional, Ovaert, Caroline, additional, Houeijeh, Ali, additional, Combes, Nicolas, additional, Maury, Philippe, additional, Duthoit, Guillaume, additional, Hiel, Bérengère, additional, Erickson, Christopher C., additional, Bonnet, Caroline, additional, Van Hare, George F., additional, Dina, Christian, additional, Karsenty, Clément, additional, Fournier, Emmanuelle, additional, Le Bloa, Mathieu, additional, Pass, Robert H., additional, Liberman, Leonardo, additional, Happonen, Juha-Matti, additional, Perry, James C., additional, Romefort, Bénédicte, additional, Benbrik, Nadir, additional, Hauet, Quentin, additional, Fraisse, Alain, additional, Gatzoulis, Michael A., additional, Abrams, Dominic J., additional, Dubin, Anne M., additional, Ho, Siew Yen, additional, Redon, Richard, additional, Bacha, Emile A., additional, Schott, Jean-Jacques, additional, and Baruteau, Alban-Elouen, additional

Published
2022
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7. Health Outcomes of 215 Mothers of Children With Autoimmune Congenital Heart Block: Analysis of the French Neonatal Lupus Syndrome Registry.

Author

Miniaoui, Imene, Morel, Nathalie, Lévesque, Kateri, Maltret, Alice, Driessen, Marine, Masseau, Agathe, Orquevaux, Pauline, Piette, Jean-Charles, Barriere, Francois, Le Bidois, Jérome, Georgin-Lavialle, Sophie, Guettrot-Imbert, Gaëlle, Le Guern, Véronique, Mouthon, Luc, Jallouli, Moez, Deligny, Christophe, Hachulla, Eric, Romefort, Bénédicte, Bonnet, Damien, and Costedoat-Chalumeau, Nathalie

Published
2022
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9. Improved ventilation and hospital stay in premature babies after transcatheter closure of patent ductus arteriosus as compared to surgical ligation: A multi-center comparative study

Author

Baruteau, Alban-Elouen, primary, Regan, William, additional, Benbrik, Nadir, additional, Sharma, Shiv, additional, Auriau, Johanne, additional, Romefort, Bénédicte, additional, Prigent, Solène, additional, Le Gloan, Laurianne, additional, Bautista, Carles, additional, Sirico, Domenico, additional, Guérin, Patrice, additional, Rozé, Jean-Christophe, additional, di Salvo, Giovanni, additional, Foldvari, Sandrine, additional, and Fraisse, Alain, additional

Published
2019
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12. Neonatal Marfan Syndrome: Report of a Case with an Inherited Splicing Mutation outside the Neonatal Domain

Author

Le Gloan, Laurianne, primary, Hauet, Quentin, additional, David, Albert, additional, Hanna, Nadine, additional, Arfeuille, Chloé, additional, Arnaud, Pauline, additional, Boileau, Catherine, additional, Romefort, Bénédicte, additional, Benbrik, Nadir, additional, Gournay, Véronique, additional, Joram, Nicolas, additional, Baron, Olivier, additional, and Isidor, Bertrand, additional

Published
2015
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14. Developing cell therapy techniques for respiratory disease: intratracheal delivery of genetically engineered stem cells in a murine model of airway injury.: Stem cell therapy for respiratory disease

Author

Leblond, Anne-Laure, Naud, Patrice, Forest, Virginie, Gourden, Clothilde, Sagan, Christine, Romefort, Bénédicte, Mathieu, Eva, Delorme, Bruno, Collin, Christine, Pagès, Jean-Christophe, Sensebé, Luc, Pitard, Bruno, Lemarchand, Patricia, Lemarchand, Patricia, Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiopathies et mort subite [ERL 3147], Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), In-Cell-Art, Service d'Anatomo-Pathologie, Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biochimie et Biologie Moléculaire, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Virus, pseudo-virus: Morphogénèse et Antigénicité, Université de Tours (UT)-EA3856, Service recherche, EFS, and This work was supported in part by a grant from 'Vaincre la Mucoviscidose' (Paris, France).

Subjects
MESH: DNA Primers, MESH: Indoles, MESH: Bronchoalveolar Lavage, MESH: Transfection, MESH: Tissue Therapy, MESH: Enzyme-Linked Immunosorbent Assay, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, respiratory system, MESH: Male, respiratory tract diseases, MESH: beta-Galactosidase, MESH: Genetic Vectors, MESH: Analysis of Variance, MESH: Genetic Engineering, MESH: Animals, MESH: Mesenchymal Stem Cell Transplantation, MESH: Galactosides, MESH: Respiratory Tract Diseases, MESH: Embryonic Stem Cells, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, MESH: Mice, MESH: Trachea
Abstract

International audience; Interest has increased in the use of exogenous stem cells to optimize lung repair and serve as carriers of a therapeutic gene for genetic airway diseases such as cystic fibrosis. We investigated the survival and engraftment of exogenous stem cells after intratracheal injection, in a murine model of acute epithelial airway injury already used in gene therapy experiments on cystic fibrosis. Embryonic stem cells and mesenchymal stem cells were intratracheally injected 24 hr after 2% polidocanol administration, when epithelial airway injury was maximal. Stem cells were transfected with reporter genes immediately before administration. Reporter gene expression was analyzed in trachea-lungs and bronchoalveolar lavage, using nonfluorescence, quantitative, and sensitive methods. Enzyme-linked immunosorbent assay quantitative results showed that 0.4 to 5.5% of stem cells survived in the injured airway. Importantly, no stem cells survived in healthy airway or in the epithelial lining fluid. Using 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside staining, transduced mesenchymal stem cells were detected in injured trachea and bronchi lumen. When the epithelium was spontaneously regenerated, the in vivo amount of engrafted mesenchymal stem cells from cell lines decreased dramatically. No stem cells from primary culture were located within the lungs at 7 days. This study demonstrated the feasibility of intratracheal cell delivery for airway diseases with acute epithelial injury.

Published
2009

19. Late repair of tetralogy of Fallot during childhood in patients from developing countries.

Author

Benbrik, Nadir, Romefort, Bénédicte, Le Gloan, Laurianne, Warin, Karine, Hauet, Quentin, Guerin, Patrice, Baron, Olivier, and Gournay, Véronique

Subjects
*TETRALOGY of Fallot, *CARDIAC surgery, *POLYCYTHEMIA, *VENTRICULAR outflow obstruction, *PERICARDIAL effusion, *CHILDREN'S health, *CHILDREN, *THERAPEUTICS, DEVELOPING countries
Abstract

OBJECTIVES Although the current surgical approach of tetralogy of Fallot (TOF) is primary complete repair in infancy, late diagnosis and lack of surgical facilities in developing countries may delay surgical treatment. Some of these patients exposed to prolonged chronic hypoxaemia are transferred to more privileged countries to undergo surgical repair with the support of non-governmental organizations. The objective of this single-centre retrospective study was to compare the postoperative outcomes of these foreign patients undergoing delayed repair with those of patients born in France undergoing timely repair during the same time period. METHODS The computer database of our institution was searched for all cases of TOF in foreign patients younger than 15 years, supported by two non-profit organizations, who underwent complete repair between January 2007 and December 2013. The control population consisted of the patients with TOF born in France, who underwent timely complete repair during the same period. RESULTS The 47 foreign children were older (57.6 ± 38.4 vs 8.3 ± 9.1 months, P < 0.0001), more hypoxaemic (SaO2 79 ± 11 vs 91 ± 8%, P < 0.0001), more growth-retarded (body mass index Z-score −1.35 ± 1.5 vs −0.46 ± 1.3, P = 0.0034), and had higher haematocrit level (52.5 ± 11.7 vs 37.5 ± 6.1%, <0.0001) and worse left ventricular ejection fraction (LVEF 62 ± 8 vs 69 ± 3.8%, P < 0.0001) than the 90 French patients. Postoperative mortality and morbidity (sepsis, arrhythmia, bleeding and need for surgical revision) were similar in the two groups, except for a higher rate of pericardial and/or pleural effusion in foreign children (36 vs 17%, P = 0.02). Length of stay was shorter in foreign than in French patients (11 ± 6 vs 15 ± 15 days, P = 0.0012). CONCLUSIONS In our experience, despite the presence of several risk factors (growth retardation, chronic hypoxaemia, polycythaemia and left ventricular dysfunction), late repair of TOF was undertaken during childhood in patients from developing countries with no difference in postoperative morbidity and mortality compared with that of timely repair during infancy. These older patients can be discharged sooner. However, patients undergoing late surgery may be at higher risk of complications of right ventricular failure, such as pleural and/or pericardial effusion. [ABSTRACT FROM PUBLISHER]

Published
2015
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20. Developing cell therapy techniques for respiratory disease: intratracheal delivery of genetically engineered stem cells in a murine model of airway injury.

Author

Leblond AL, Naud P, Forest V, Gourden C, Sagan C, Romefort B, Mathieu E, Delorme B, Collin C, Pagès JC, Sensebé L, Pitard B, and Lemarchand P

Subjects
Analysis of Variance, Animals, Bronchoalveolar Lavage, DNA Primers genetics, Enzyme-Linked Immunosorbent Assay, Galactosides, Genetic Engineering methods, Genetic Vectors, Indoles, Male, Mice, Transfection, beta-Galactosidase, Cell- and Tissue-Based Therapy methods, Embryonic Stem Cells transplantation, Mesenchymal Stem Cell Transplantation methods, Respiratory Tract Diseases therapy, Trachea cytology
Abstract

Interest has increased in the use of exogenous stem cells to optimize lung repair and serve as carriers of a therapeutic gene for genetic airway diseases such as cystic fibrosis. We investigated the survival and engraftment of exogenous stem cells after intratracheal injection, in a murine model of acute epithelial airway injury already used in gene therapy experiments on cystic fibrosis. Embryonic stem cells and mesenchymal stem cells were intratracheally injected 24 hr after 2% polidocanol administration, when epithelial airway injury was maximal. Stem cells were transfected with reporter genes immediately before administration. Reporter gene expression was analyzed in trachea-lungs and bronchoalveolar lavage, using nonfluorescence, quantitative, and sensitive methods. Enzyme-linked immunosorbent assay quantitative results showed that 0.4 to 5.5% of stem cells survived in the injured airway. Importantly, no stem cells survived in healthy airway or in the epithelial lining fluid. Using 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside staining, transduced mesenchymal stem cells were detected in injured trachea and bronchi lumen. When the epithelium was spontaneously regenerated, the in vivo amount of engrafted mesenchymal stem cells from cell lines decreased dramatically. No stem cells from primary culture were located within the lungs at 7 days. This study demonstrated the feasibility of intratracheal cell delivery for airway diseases with acute epithelial injury.

Published
2009
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