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1. Interfering activity of epidemic, attenuated and recombinant strains of influenza A virus

Author

Romanova YuR, F I, Polezhaev, M A, Shneider, and G I, Aleksandrova

Subjects
Recombination, Genetic, Cytopathogenic Effect, Viral, Genes, Viral, Species Specificity, Influenza A virus, Mutation, Viral Interference, Temperature, Animals, Vaccinia virus, Chick Embryo, Cells, Cultured
Abstract

Interfering activity (IA) of the epidemic and attenuated influenza virus strains of different ts-phenotype was studied. IA was assessed by inhibition of vaccinia virus cytopathic effect in chick embryo chorioallantoic membrane (CAM) cells. Direct relationship was established between the temperature sensitivity (ts) index and IA of these viruses. The relationship between IA and multiplicity of infection was strain-specific.

Published
1986

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