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3. Continuity of Hausdorff Dimension Across Generic Dynamical Lagrange and Markov Spectra II

Author

Cerqueira, A., Moreira, C. G., and Romaña, S.

Subjects
Mathematics - Dynamical Systems, Mathematics - Differential Geometry
Abstract

Let $g_0$ be a smooth pinched negatively curved Riemannian metric on a complete surface $N$, and let $\Lambda_0$ be a basic hyperbolic set of the geodesic flow of $g_0$ with Hausdorff dimension strictly smaller than two. Given a small smooth perturbation $g$ of $g_0$ and a smooth real-valued function $f$ on the unit tangent bundle to $N$ with respect to $g$, let $L_{g,\Lambda,f}$, resp. $M_{g,\Lambda,f}$ be the Lagrange, resp. Markov spectrum of asymptotic highest, resp. highest values of $f$ along the geodesics in the hyperbolic continuation $\Lambda$ of $\Lambda_0$. We prove that, for generic choices of $g$ and $f$, the Hausdorff dimension of the sets $L_{g,\Lambda, f}\cap (-\infty, t)$ vary continuously with $t\in\mathbb{R}$ and, moreover, $M_{g,\Lambda, f}\cap (-\infty, t)$ has the same Hausdorff dimension of $L_{g,\Lambda, f}\cap (-\infty, t)$ for all $t\in\mathbb{R}$.

Published
2017

6. LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Author

Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., Sorensen, R., Forster, A., Fraser, P., Cohen, J. I., Alexander, I., Wintergerst, U., Frebourg, T., Aurias, A., Stoppa-Lyonnet, D., Romana, S., Radford-Weiss, I., Gross, F., Valensi, F., Delabesse, E., Macintyre, E., Sigaux, F., Soulier, J., Leiva, L. E., Wissler, M., Prinz, C., Rabbitts, T. H., Le Deist, F., Fischer, A., and Cavazzana-Calvo, M.

Published
2003

10. Sales of Innovation Products by Engineering Enterprises

Author

Kuzmin Oleh Ye. and Kostsyk Romana S.

Subjects
innovations, commercialisation, sales, innovation products, commercialisation forms, commercialisation methods, Business, HF5001-6182
Abstract

The goal of the article is formation of stages of sales of innovation products of engineering enterprises as a method of commercialisation of innovations. For this purpose the article conducts analysis of scientific literature that deals with forms and methods of commercialisation of innovation products. The article also considers views of scientists with respect to commercialisation of innovations by means of their use at own enterprise. In the course of analysis it was revealed that the use of innovation products at own enterprises, namely its sales, is the most rational method of commercialisation of innovations. This method is directed at gaining the maximum profit in the enterprise activity. The article offers stages of sales of innovation products by engineering enterprises. It also describes each stage of this process and its essence. Further studies will have to pay more attention to the study of each stage of sales of innovation products of engineering enterprises individually. It is also necessary to identify and create formulae for calculation of all quantitative indicators required for sales of innovations.

Published
2014

14. Genetic counselling difficulties and ethical implications of incidental findings from array-CGH: a 7-year national survey

Author

Lefebvre, M., Sanlaville, D., Marle, N., Thauvin-Robinet, C., Gautier, E., Chehadeh, S. E., Mosca-Boidron, A.-L., Thevenon, J., Edery, P., Alex-Cordier, M.-P., Till, M., Lyonnet, S., Cormier-Daire, V., Amiel, J., Philippe, A., Romana, S., Malan, V., Afenjar, A., Marlin, S., Chantot-Bastaraud, S., Bitoun, P., Heron, B., Piparas, E., Morice-Picard, F., Moutton, S., Chassaing, N., Vigouroux-Castera, A., Lespinasse, J., Manouvrier-Hanu, S., Boute-Benejean, O., Vincent-Delorme, C., Petit, F., Meur, N. L., Marti-Dramard, M., Guerrot, A.-M., Goldenberg, A., Redon, S., Ferrec, C., Odent, S., Caignec, C. L., Mercier, S., Gilbert-Dussardier, B., Toutain, A., Arpin, S., Blesson, S., Mortemousque, I., Schaefer, E., Martin, D., Philip, N., Sigaudy, S., Busa, T., Missirian, C., Giuliano, F., Benailly, H. K., Kien, P. K.V., Leheup, B., Benneteau, C., Lambert, L., Caumes, R., Kuentz, P., François, I., Heron, D., Keren, B., Cretin, E., Callier, P., Julia, S., and Faivre, L.

Published
2016
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17. Knowledge and skill

Author

Durrani, Romana S., primary, Usman, Ali, primary, Gardezi, Amina Batol, primary, and Abid, Maham, primary

Published
2021
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21. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique

Author

Romana, S P, Radford-Weiss, I, Ben Abdelali, R, Schluth, C, Petit, A, Dastugue, N, Talmant, P, Bilhou-Nabera, C, Mugneret, F, Lafage-Pochitaloff, M, Mozziconacci, M-J, Andrieu, J, Lai, J-L, Terre, C, Rack, K, Cornillet-Lefebvre, P, Luquet, I, Nadal, N, Nguyen-Khac, F, Perot, C, Van den Akker, J, Fert-Ferrer, S, Cabrol, C, Charrin, C, Tigaud, I, Poirel, H, Vekemans, M, Bernard, O A, and Berger, R

Published
2006
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22. AB0758 REAL-WORLD EFFICACY AND SAFETY OF APREMILAST IN BELGIAN PATIENTS WITH PSORIATIC ARTHRITIS: FINAL ANALYSIS OF THE MULTICENTRE, PROSPECTIVE APOLO STUDY

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, De Vlam, K., Nzeusseu Toukap, Adrien, Kaiser, M. J., Vanhoof, J., Remans, P., DI Romana, S., Van den Bosch, F., Vanhoof, V., Lories, R., UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, De Vlam, K., Nzeusseu Toukap, Adrien, Kaiser, M. J., Vanhoof, J., Remans, P., DI Romana, S., Van den Bosch, F., Vanhoof, V., and Lories, R.

Abstract

Background: Real-world evidence on the efficacy and safety for patients (pts) with psoriatic arthritis (PsA) treated with apremilast (APR) is lacking but required to understand the uptake and potential of the drug. Objectives: To assess the efficacy and safety of APR in pts with active PsA from routine clinical practice in Belgium. Methods: In this multicentre, prospective study, the primary endpoint was the PsA Response Criteria (PsARC) response 6 months after APR initiation, defined as improvement in ≥2 (at least 1 must be joint swelling or tenderness) and no worsening in any of 4 criteria: swollen joint count (SJC [0-66]), tender joint count (TJC [0-68]), Physician’s Global Assessment of Disease Activity and Pt’s Global Assessment of Disease Activity. Other endpoints included the 12-item PsA Impact of the Disease (PsAID12) questionnaire, Health Assessment Questionnaire-Disability Index (HAQ-DI), Physician’s and Pt’s Numerical Rating Scale assessing disease activity for the most affected joint, psoriasis-involved body surface area, enthesitis, dactylitis and pain. Results: In total, 107 pts were enrolled and included in the baseline (BL) demographics/disease characteristics and safety analyses. The efficacy population comprised 69 pts (pts who started APR ≤30 days before inclusion in the study and completed ≥150 days of treatment). Mean age was 53 years, mean body mass index was 29 kg/m2 and 56% were female. Mean duration of PsA was ≈8 years (87.1 months). One-third of pts presented with short disease duration (time since diagnosis of PsA: ≤2 years); 84% were biologic naive. The most frequently reported comorbidities were cardiovascular disease (30%) and hypercholesterolemia (24%). At BL, mean (SD) SJC was 8.0 (6.5); mean (SD) TJC was 14.2 (12.5). Pts from the efficacy population were representative of the overall population. Fifty-four pts (60%) continued APR treatment for 6 months; 38 (36%) had discontinued APR (insufficient efficacy: n=15; adverse events [AEs]

Published
2020

26. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Author

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M.P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C.S., Pawliuk, R., Morillon, E., Sorensen, R., Forster, A., Fraser, P., Cohen, J.I., de Saint Basile, G., Alexander, I., Wintergerst, U., Frebourg, T., Aurias, A., Stoppa-Lyonnet, D., Romana, S., Radford-Weiss, I., Gross, F., Valensi, F., Delabesse, E., Macintyre, E., Sigaux, F., Soulier, J., Leiva, L.E., Wissler, M., Prinz, C., Rabbitts, T.H., Le Deist, F., Fischer, A., and Cavazzana-Calvo, M.

Subjects
Physiological aspects, Complications and side effects, Research, Gene therapy -- Research -- Physiological aspects, Retroviruses -- Research -- Physiological aspects
Abstract

Ex vivo retrovirus-mediated gene transfer into hematopoietic progenitor cells has been shown to be an efficient strategy to correct inherited diseases of the lymphohematopoietic system, provided that a strong selective [...], We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as γ chain (γc) deficiency] in 9 out of 10 patients by retrovirus-mediated γc gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncontrolled exponential clonal proliferation of mature T cells (with γδ+ or αβ+ T cell receptors) has occurred in the two youngest patients. Both patients' clones showed retrovirus vector integration in proximity to the LMO2 proto-oncogene promoter, leading to aberrant transcription and expression of LMO2. Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.

Published
2003

44. Factors associated with older patients' misunderstandings of medication dosage regimen instructions after consultation in primary care in Brazil.

Author

Amorim, Welma W., Passos, Luiz C., Gama, Romana S., Souza, Renato M., and Oliveira, Marcio G.

Subjects
CONFIDENCE intervals, CROSS-sectional method, MULTIVARIATE analysis, PRIMARY health care, INFORMATION literacy, MEDICAL referrals, DRUGS, CHI-squared test, DESCRIPTIVE statistics, PATIENT compliance, DATA analysis software, ELDER care, OLD age
Abstract

Rationale, aims, and objectives: Misunderstanding medication dosage regimen instructions can lead to unintentional misuse of a prescribed medicine, non‐adherence to providers' instructions, and other treatment‐related issues. We aimed to evaluate the frequency of and factors associated with older patients' misunderstanding of medication dosage regimen instructions after consultation with a general practitioner. Method: This cross‐sectional study was conducted in 22 primary‐care facilities in Brazil. Data were collected from September 2016 to December 2017 using a multidimensional questionnaire. Patients who were 60 years old or older who visited primary care units were included in the study (n = 416). Results: Of the older patients interviewed, 38.2% had a misunderstanding of medication dosage regimen instructions; being female was a protective factor against the misunderstanding of medication dosage regimen instructions (prevalence ratio [PR] = 0.63; 95% confidence interval [CI] = 0.45‐0.89). In relation to other factors with an important association, misunderstanding medication dosage regimen instructions was 71% higher among illiterate participants (PR = 1.71; 95% CI = 1.25‐2.35), 39% higher among people who considered their memory to be poor (PR = 1.39; 95% CI = 1.01‐1.91), 49% higher in those who did not have a job at the time of the interview (PR = 1.49; 95% CI = 1.01‐2.19), and 50% higher in patients who had been prescribed five or more medications (PR = 1.50; 95% CI = 1.02‐2.20). Conclusions: The results showed that older people's misunderstandings of medication dosage regimen instructions after consultation with a general practitioner was greater than expected due to a range of factors, especially polypharmacy, poor literacy, poor memory, and having a job at the time of the interview. Health services and professionals should implement strategies to increase the quality of the guidance given to elderly individuals and to ensure their adherence to the regimen instructions of their medications. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries

Author

Mughal, Romana S, primary, Bridge, Katherine, additional, Buza, Irma, additional, Slaaby, Rita, additional, Worm, Jesper, additional, Klitgaard-Povlsen, Gro, additional, Hvid, Henning, additional, Schiødt, Marianne, additional, Cubbon, Richard, additional, Yuldasheva, Nadira, additional, Skromna, Anna, additional, Makava, Natallia, additional, Skytte-Olsen, Grith, additional, and Kearney, Mark T, additional

Published
2018
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48. Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice

Author

Sengupta, Anshuman, primary, Patel, Peysh A, additional, Yuldasheva, Nadira Y, additional, Mughal, Romana S, additional, Galloway, Stacey, additional, Viswambharan, Hema, additional, Walker, Andrew M N, additional, Aziz, Amir, additional, Smith, Jessica, additional, Ali, Noman, additional, Mercer, Ben N, additional, Imrie, Helen, additional, Sukumar, Piruthivi, additional, Wheatcroft, Stephen B, additional, Kearney, Mark T, additional, and Cubbon, Richard M, additional

Published
2018
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