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At the present time occur a lot of political, ideological, religion, economic crises and other conflicts that lead to global changes of social sphere. The frequent cases of local armed conflict, terrorism act takes a considerable mobilization of economic and human resources. As a rule, the professional members of a police task force occupation for maintain securities are with extreme environments. The occupational hazard effect may evident by overstrain and depletion of functional regulatory mechanisms that provide the adaptation. The law-enforcement officers of Ministry of Home Affairs, aged 23-35 years were investigated. In according to professional occupation this one was divided in three groups: combatants that send on a mission to Caucasus for maintenance of law order; law-enforcement school students; policemen that maintain law order in territory without war conflict and never take part in combat mission. The blood serum steroid hormones (cortisol, testosterone, progesterone and estradiol) were determined. It was provided comparative analysis of means between groups: combatants before – after mission; combatant – students – policemen. Analyses of our results are shown that hormonal levels at all persons were in normal physiological limits. Together with it, significant differences of steroid serum hormonal means between comparative groups as for dependent samples well as for independent samples were revealed. The differences of endocrine system index (hormonal levels of steroid hormones) at different law-enforcement officer groups with intensive professional stress are reactions for adaptation of organism to extreme factors, probably. They provide optimal adaptive changes to response on environment stress.