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Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease which involves multiple body systems (e.g., immune, nervous, digestive, circulatory) and research domains (e.g., immunology, metabolomics, the gut microbiome, genomics, neurology). Despite several decades of research, there are no established ME/CFS biomarkers available to diagnose and treat ME/CFS. Sharing data and integrating findings across these domains is essential to advance understanding of this complex disease by revealing diagnostic biomarkers and facilitating discovery of novel effective therapies. Methods The National Institutes of Health funded the development of a data sharing portal to support collaborative efforts among an initial group of three funded research centers. This was subsequently expanded to include the global ME/CFS research community. Using the open-source comprehensive knowledge archive network (CKAN) framework as the base, the ME/CFS Data Management and Coordinating Center developed an online portal with metadata collection, smart search capabilities, and domain-agnostic data integration to support data findability and reusability while reducing the barriers to sustainable data sharing. Results We designed the mapMECFS data portal to facilitate data sharing and integration by allowing ME/CFS researchers to browse, share, compare, and download molecular datasets from within one data repository. At the time of publication, mapMECFS contains data curated from public data repositories, peer-reviewed publications, and current ME/CFS Research Network members. Conclusions mapMECFS is a disease-specific data portal to improve data sharing and collaboration among ME/CFS researchers around the world. mapMECFS is accessible to the broader research community with registration. Further development is ongoing to include novel systems biology and data integration methods.

This study uses data from the Integrated Postsecondary Education Data System and Delta Cost Project to identify institutional predictors of bachelor’s degree completion rates for Pell Grant recipients and nonrecipients at public and private not-for-profit 4-year institutions. Descriptive analyses show that Pell recipients are relatively concentrated in institutions with demographic and structural characteristics associated with lower completion rates, including lower SAT scores, enrollment, and residential intensity. Multivariate analyses show that controlling for demographic and structural characteristics explains the observed negative relationship between an institution’s representation of Pell Grant recipients and its completion rates for Pell recipients. At public 4-year institutions, per full-time equivalent expenditures on instruction and institutional grants are positively related to Pell completion rates, while net price for low-income students is negatively related, after controlling for demographic and structural characteristics.

Este trabajo de investigación, considera como objetivo general: determinar la relación que existe entre el uso del software Adobe Illustrator CC 2017 y el rendimiento académico de los estudiantes de la asignatura Gráfica Vectorial Digital del Ciclo I, de la Carrera de Diseño Gráfico un Instituto privado, Lima Centro-2018. La tipología de investigación es básica, porque permitió conocer la relación entre las variables: el uso del software Adobe Illustrator y el rendimiento académico de los estudiantes. El diseño corresponde al no experimental, de alcance descriptivo correlacional. El escenario supuesto declara una arquitectura teórico lógica y constante para el efecto de análisis, ejecutándose la operacionalización de las variables, los aspectos conseguidos mediante la tenacidad de los instrumentos son corroborados que se muestran en tablas sistematizadas y en resultados estadísticos, como de sus correspondientes análisis de interpretación, permitiendo el logro de los objetivos, con los estadígrafos concernientes. Con respecto al objetivo general, se confirmó que existe relación significativa positiva muy fuerte entre el uso del software y el rendimiento académico de los estudiantes de la asignatura de Gráfica vectorial, obteniendo el coeficiente de correlación de Pearson con un valor de r = ,879. Con la seguridad que al presentar el trabajo de investigación, se esbozan algunas proyecciones al respecto, que ayudará como fundamento para los demás estudios postreros y se encuentra motivación por haber investigado el rendimiento académico de los estudiantes en la carrera de diseño. The present research work, considers as a general objective: To determine the relationship between the use of Adobe Illustrator CC 2017 software and the academic performance of the students of the Digital Vector Graphics subject of Cycle I, of the Graphic Design Career at Institute private, headquarters Lima Centro - 2018. The research typology is basic, because it allowed knowing the relationship between the variables: the use of Adobe Illustrator software and the academic performance of students. The design corresponded to the non-experimental, descriptive correlational. The supposed scenario declares a logical and constant theoretical architecture for the analysis effect, executing the operationalization of the variables and on this principle, the aspects achieved through the tenacity of the instruments are imputed that are shown in systematized tables and in statistical results, such as of their corresponding analysis of interpretation, allowing the achievement of the objectives, with the relevant statistics. Regarding the general objective, it was confirmed that there is a very strong positive significant relationship between the use of the software and the academic performance of the students of the Vector Graphics subject, obtaining the Pearson correlation coefficient with a value of r =, 879. With the certainty that when presenting the research work, some projections are outlined in this regard, which will help as a basis for the other later studies and we are motivated to have investigated one of the variables of the academic performance of the students. Escuela de Postgrado

This article reflects on the major themes that emerge in the studies presented in this volume, concentrating on implications for federal policy and future research. We emphasize that for future federal policy to be successful, it will need to be revamped in ways that are relatively nuanced, encouraging (among other things) enrollment and persistence to degree completion among students who might not otherwise take loans or go to college, protecting taxpayers and students against investments in low-performing colleges, making federal loan programs more understandable to students who need them, and reducing the risks of student loan nonrepayment. For future research we make numerous recommendations, including calls for attention to debt aversion, income-based loan repayment, and the effects of borrowing on a broad range of student outcomes.

Resumen en español: "La broca del café, Hypothenemus hampei (Ferrari), es la plaga más importante del café, Coffea spp., en el mundo. Este insecto ha sido motivo de numerosos estudios, sin embargo, muchos aspectos de su dispersión se desconocen o requieren ser determinados. La presente investigación tuvo el objetivo de estudiar los factores que influyen en la dispersión espacio-temporal de la broca del café. Dado que la dispersión es un proceso complejo, para ser estudiada se desarrollaron técnicas para la obtención del material biológico con condiciones adecuadas para el estudio, para facilitar el estudio de la morfología del complejo espermático de H. hampei y de marcaje-liberación-recaptura para estudiar la capacidad de vuelo y los factores que la afectan. Los resultados más sobresalientes indican que la espermateca de H. hampei está ubicada en la parte final del abdomen entre la glándula accesoria y el oviducto común y está compuesta por un ducto espermático, músculos espermáticos y una glándula espermática; además, posee músculos al final de su curvatura extrema y su cutícula está finamente reticulada. Los espermatozoides se observaron como filamentos minúsculos, endebles y homogéneos, congregados longitudinalmente dentro de la espermateca. La emergencia masiva de las CH se relacionó con las lluvias y se presentó entre febrero y junio, que corresponde al periodo intercosecha. Todas las CH examinadas tenían espermatozoides en la espermateca, lo que sugiere que se habían apareado antes de abandonar el fruto natal. La sobrevivencia de las hembras colonizadoras fue mayor en ambientes humedos y en sustratos diferentes a su hospedero. Durante el periodo de fructificación del café, las hembras se dispersaron mediante vuelo a los glomérulos de frutos adyacentes. Después de colonizar un fruto, la CH perdió su capacidad de vuelo de forma gradual en el transcurso de 5 a 6 días; durante este tiempo, las hembras evaluadas realizar más de un vuelo. Algunas CH marcadas y liberadas se recapturaron a 75 m de distancia del sitio de liberación a las 24 h después de haber sido liberadas. Finalmente, se discute la importancia de los hallazgos de la dispersión espacio-temporal de la broca del café, como información clave para mejorar la comprensión del complejo café-broca, y el manejo de la broca. "

PURPOSE: To evaluate the visual and refractive results of conventional (non-wavefront) laser in situ keratomileusis (LASIK) for treatment of myopia and myopic astigmatism using the Alcon LADARVision 4000 excimer laser system and nomogram adjustment techniques. METHODS: A retrospective analysis of 499 eyes that had LASIK for myopia and myopic astigmatism was performed. Preoperative manifest spherical equivalent refraction ranged from -0.43 to -6.00 D and preoperative astigmatism ranged from 0 to -4.75 D. Patients were evaluated during 3 months following surgery. RESULTS: One month after surgery, 72% of eyes examined (298/415 eyes) had uncorrected visual acuity (UCVA) of 20/20 or better. Three months after surgery, 83% of eyes examined (216/261 eyes) had UCVA of 20/20 or better. One and three months after surgery, 82% and 83% of eyes, respectively, were within ?0.50 D of attempted correction; 97% of eyes were within ?1.00 D at both 1 and 3 months. No eye lost more than 1 line of best spectacle-corrected visual acuity (BSCVA) at 3 months after surgery. At the 3 -month examination, 83% of eyes had UCVA better than or equal to preoperative BSCVA. CONCLUSIONS: Conventional LASIK to correct myopia and myopic astigmatism was safe and effective using the Alcon LADARVision 4000 excimer laser system. Outcomes were substantially improved throughout development of an accurate nomogram, derived from continually updated regression analysis of previous refractive results. [J Refract Surg 2004; 20:364-370]

Resumen en español: "El desarrollo del presente trabajo, es un estudio de comparación que tiene como objetivo estimar la seguridad alimentaria desde la perspectiva de disponibilidad, acceso y consumo de alimentos que requieren para su vida diaria, las familias de las tres microrregiones indígenas del municipio de Oxchuc (Pashtónticjá, El Tzay y Oxchuc, centro), Chiapas, México, mediante el enfoque de Modos de Vida Sustentable (MVS), ya que permite analizar mediante métodos cualitativos los recursos esenciales para satisfacer la seguridad alimentaria del hogar y permite identificar estrategias que modifican los modos de vida de los habitantes del municipio. El estudio se desarrolló en dos partes, en la primer parte, se identifica los modos de vida que tienen las familias a través de un análisis municipal con enfoque en MVS. En la segunda parte, se analizó la seguridad alimentaria, estrategias y vulnerabilidad de las familias a través de técnicas participativas en grupos focales; todo esto en función de los resultados obtenidos del diagnóstico rural rápido (análisis municipal). Los resultados obtenidos señalan, que las familias de la microrregión de Pashtonticjá tienen mayor seguridad alimentaria al satisfacer en más del 70% de sus requerimientos alimenticios por tener una producción de granos básicos para consumo, a diferencia de los dos microregiones restantes que satisfacen menos del 60% de sus requerimientos alimenticios por ser regiones dedicadas a la renta de mano de obra (Oxchuc) y producción de café comercial (El Tzay), a pesar de esto las tres microrregiones presentan un nivel de pobreza de muy pobres, en consecuencia, las familias presentan inseguridad alimentaria con ingresos inferiores a la línea de pobreza (FAO) y gastos fuertes en alimentos. Finalmente las familias presentan inseguridad alimentaria y generan estrategias para enfrentarlo (subsidios, migración, entre otras), esto les permiten adaptarse a los cambios en el entorno. "

PURPOSE: To compare outcomes after LASIK surgery using the conventional LADARVision4000 laser and the wavefront-guided LADARWave CustomCornea wavefront system. METHODS: A prospective study was performed involving 140 myopic eyes receiving conventional or CustomCornea LASIK between May and October 2003. The preoperative manifest spherical equivalent refraction was limited to myopia =s-7.00 diopters (D). The preoperative manifest cylinder was limited to ^s -2.50 D of astigmatism. Patients were evaluated for 3 months following surgery. Results evaluated were uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity, manifest refraction, dilated wavefront measurements, contrast sensitivity, and patient responses to subjective questionnaires. RESULTS: For the CustomCornea eyes at 3 months, 80% (70/87) had UCVA 2*20/20 and 95% (83/87) had UCVA > 20/25. For the conventional eyes at 3 months, 45% (9/20) had UCVA >20/20 and 80% (16/20) had UCVA >20/25. At the 3-month postoperative visit, 85% (74/87) of the CustomCornea eyes and 55% (11/20) of the conventional eyes were within ?0.50 D of their intended correction. At 1 and 3 months, the CustomCornea treated eyes had a statistically significant lower mean increase in higher order aberrations than conventionally treated eyes (P CONCLUSIONS: CustomCornea wavefront-guided LASIK surgery appears safe and effective and provides clinical benefits that appear to exceed those of conventional LADARVision surgery. [J Refract Surg. 2005;21:S786S791.]