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4. Chronic Microelectrode Investigations of Normal Human Brain Physiology Using a Hybrid Depth Electrode

Author

Roman Mirsky, P. Charles Garell, Igor O. Volkov, Mark A. Granner, M. Daniel Noh, and Matthew A. Howard

Subjects
Brain Mapping, Epilepsy, medicine.diagnostic_test, education, Action Potentials, Brain, Equipment Design, Human brain, Electroencephalography, EEG-fMRI, Electrodes, Implanted, Stereotaxic Techniques, Microelectrode, medicine.anatomical_structure, medicine, Humans, Surgery, Depth electrode, Neurology (clinical), Psychology, Microelectrodes, Clinical treatment, Neuroscience
Abstract

Neurosurgeons have unique access to in vivo human brain tissue, and in the course of clinical treatment important scientific advances have been made that further our understanding of normal brain physiology. In the modern era, microelectrode recordings have been used to systematically investigate the cellular properties of lateral temporal cerebral cortex. The current report describes a hybrid depth electrode (HDE) recording technique that was developed to enable neurosurgeons to simultaneously investigate normal cellular physiology during chronic intracranial EEG recordings. The HDE combines microelectrode and EEG recordings sites on a single shaft. Multiple microelectrode recordings are obtained from MRI defined brain sites and single-unit activity is discriminated from these data. To date, over 60 HDEs have been placed in 20 epilepsy surgery patients. Unique physiologic data have been gathered from neurons in numerous brain regions, including amygdala, hippocampus, frontal lobe, insula and Heschl's gyrus. Functional activation studies were carried out without risking patient safety or comfort.

Published
1997
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5. Stereotactic and Image-Guided Surgery: Abstracts

Author

Stefan Kunze, J.H. Song, Catherine Fischer, D. Hellwig, Andrey V. Oblyapin, H. Bertalanffy, Juriy Z. Polonskiy, M. Wallace, Dennis E. Bullard, In Ki Mun, Volker M. Tronnier, Grégoire Malandain, W.R. Niendorf, C. Vial, Matthew A. Howard, Mario M. Bonsanto, Franck Sturtz, Andrey D. Anichkov, François Mauguière, Friedrich K. Albert, Jacques Favre, J. Mukawa, Y. Muragaki, Igor O. Volkov, D.S. Casolino, R.R. Tasker, D. Heyman, E. Emery, Bernard Laurent, Jin Woo Chang, K. Yamashiro, Joseph A. Maldjian, B. Abdennebi, Peter McL. Black, R. Andrews, Audun Stubhaug, Michael L. Levy, E. Franchin, A. Perneczky, Jacques Feldmar, Thomas M. Moriarty, Luis Garcia-Larrea, K. Roessler, Roman Mirsky, A. Cavaggioni, C.W. Dempsey, Joon Hyong Cho, A. Ishida, J.R. Schvarcz, T. Taira, L. Benes, M. Iwahara, Wen-Ching Liu, Y. Yoshii, Frédéric Bonnefoi, T. Nedjahi, H.W.S. Schroeder, William T. O'Connor, M. Daniel Noh, Andreas Staubert, J.C. Acevedo, G. Antoniadis, Yong Gou Park, L. Mahfouf, Eben Alexander, M.R. Gaab, F. Lavenne, Märta Segerdahl, Arcady V. Korzenev, R. Papasin, Luc Picard, Vadim Yakhnitsa, Per Kristian Eide, Serge Bracard, Y. Masutani, Björn A. Meyerson, K. Ericson, N.L. Dorward, Y. Terada, Peter W. Carmel, C. Manelfe, Jeffrey Labuz, Ch. Matula, Nicholas Ayache, P. Shamsgovara, I. Berry, Ron Kikinis, D. Albe-Fessard, Kazuhiro Katada, T. Dohi, P. Charles Garell, N.D. Kitchen, A.T. Bergenheim, Kim J. Burchiel, Xiaozhuo Chen, Olof Flodmark, D.E. Richardson, Marshall Devor, Th. Czech, M. Aichholzer, N. Hopf, Vladimir B. Nizkovolos, Janine Shulok, Chul-Won Park, L. Casentini, Laurent Launay, J. Sabatier, Marc Sindou, G. Palù, Ruth Govrin-Lippmann, W. Wagner, Sang Sup Chung, Karen Waddell, P. Calvi, P. Grunert, Y. Lajat, Kirk Moffitt, Vladimir A. Shoustin, A. Galvagni, Ferenc M. Jolesz, Patrick Mertens, C.R. Wirtz, W.Th. Koos, H.-P. Richter, W. Dietrich, Michael Knauth, Yong Ko, Margareta B. Møller, P.-Å. Ridderheim, H. Ralph Snodgrass, Mark A. Granner, Bengt Linderoth, R. Deinsberger, J.F. Kahamba, Carl-Olav Stiller, Jamal M. Taha, N. Tomiyama, Joseph C.T. Chen, Kazuhiko Nonomura, Philip L. Gildenberg, K. Boulanouar, K. Ungersboeck, M. Tremoulet, S.A. Rath, G. Lanner, H. Goerzer, Blaine S. Nashold, R. Mah, Marie-Claude Gregoire, Krupa Shanker, Eric Maurincomme, Kyung Hoe Lee, J. Winters, Z. Harry Rappaport, F.E. Roux, E. Blondet, Michael Söderman, Doros Platika, M.C. Spendel, C. Giorgi, Michael Schulder, B.L. Bauer, T. Tanikawa, René Anxionnat, D.G.T. Thomas, M. Guerrero, M. Zanusso, K. Seitz, W. Tschiltschke, O. Alberti, Alf Sollevi, H. Iseki, F. Colombo, Erwan Kerrien, N. Soliman, K. Takakura, Jian-Guo Cui, Tetsuo Kanno, J.P. Ranjeva, Roland Peyron, and D. Menegalli-Boggelli

Subjects
medicine.medical_specialty, Image-guided surgery, business.industry, medicine, Surgery, Medical physics, Neurology (clinical), business
Published
1997
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6. An integrated multipurpose lesion-making electrode

Author

Igor O. Volkov, Lori K. Reed, Bruce A. Abkes, Roman Mirsky, and Matthew A. Howard

Subjects
medicine.medical_specialty, medicine.medical_treatment, Neurosurgery, Action Potentials, Brain tissue, Lesion, Stereotaxic Techniques, medicine, Animals, Pallidotomy, Electrodes, Medial geniculate nucleus, Brain Mapping, business.industry, Geniculate Bodies, Equipment Design, Surgery, Clinical Practice, Microelectrode, Electrode, Cats, Neurology (clinical), medicine.symptom, business, Microelectrodes, Lesion site, Biomedical engineering
Abstract

PURPOSE: Although excellent results are reported from centers using microelectrode mapping during stereotactic pallidotomy, the recording methods used are time-consuming and technically cumbersome. We sought to develop a new electrode concept that may, when eventually applied in clinical practice, improve the efficiency and safety of microelectrode-guided functional neurosurgical procedures. CONCEPT: The scout electrode uses a recently developed research technique for simultaneously obtaining multiple microelectrode recordings along the shaft of a macroelectrode. RATIONALE: By positioning recording sites on either side of a lesion-making contact, it is possible to functionally scout the brain tissue surrounding the proposed lesion site, thus eliminating the need for serial movements and electrode interchanges. DISCUSSION: The feasibility of the scout electrode concept was tested using prototypes placed into cat medial geniculate nucleus. High-quality unit recordings were simultaneously obtained from different regions within the medial geniculate nucleus. This ability to physiologically map sites above and below the lesion-making contact facilitated precise placement of radiofrequency lesions in the center of the medial geniculate nucleus. These results suggest that it may be possible to develop clinically useful devices based on this novel concept.

Published
1998

7. Pupillary Studies of The Retinal 'off' Response

Author

Randy H. Kardon and Roman Mirsky

Abstract

It has been known for many years that not all electrical discharges arising from the retina are due to a light stimulus. Some occur as a result of the light being turned off. The "off" response of the retina was recorded in early electroretinographic studies (1-3) when the light stimulus used was not of such short duration as used in present studies with the xenon flash. The "off response is also a well recognized spike discharge from a certain population of retinal ganglion cells that only seem to respond when a light stimulus is terminated (4,5). Similar recordings have been characterized from the lateral geniculate nucleus (6), the pretectal pupillocontrictor centers (7), and the ciliary nerves (8,9).

Published
1991
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8. Transplantation and Gene Therapy: Abstract

Author

Jacques Favre, D. Albe-Fessard, Frédéric Bonnefoi, T. Nedjahi, D.S. Casolino, Märta Segerdahl, Michael Schulder, Arcady V. Korzenev, R. Papasin, Dennis E. Bullard, E. Emery, William T. O'Connor, A. Galvagni, H. Goerzer, Th. Czech, Janine Shulok, K. Boulanouar, L. Mahfouf, Chul-Won Park, P. Grunert, Nicholas Ayache, P. Charles Garell, Ferenc M. Jolesz, F. Lavenne, F. Colombo, Erwan Kerrien, N. Hopf, J. Winters, Bernard Laurent, C.R. Wirtz, F.E. Roux, Yong Ko, Margareta B. Møller, Xiaozhuo Chen, Bengt Linderoth, N.D. Kitchen, A.T. Bergenheim, T. Dohi, D.E. Richardson, M. Aichholzer, H. Iseki, H. Ralph Snodgrass, Marshall Devor, W.R. Niendorf, M.C. Spendel, Marc Sindou, Y. Muragaki, N.L. Dorward, Y. Terada, N. Soliman, K. Takakura, Kyung Hoe Lee, Thomas M. Moriarty, Andrey D. Anichkov, Blaine S. Nashold, Roman Mirsky, Jeffrey Labuz, François Mauguière, H.-P. Richter, R.R. Tasker, D. Heyman, B.L. Bauer, T. Tanikawa, R. Mah, Z. Harry Rappaport, D.G.T. Thomas, Joseph C.T. Chen, Michael J. Levy, K. Ungersboeck, Andrey V. Oblyapin, Audun Stubhaug, L. Casentini, B. Abdennebi, Krupa Shanker, E. Franchin, Jacques Feldmar, René Anxionnat, Catherine Fischer, Kirk Moffitt, Wen-Ching Liu, M. Zanusso, In Ki Mun, Volker M. Tronnier, K. Roessler, K. Seitz, Luc Picard, Eric Maurincomme, Grégoire Malandain, Vadim Yakhnitsa, Andreas Staubert, Peter W. Carmel, C. Manelfe, E. Blondet, T. Taira, M. Guerrero, Mario M. Bonsanto, Kazuhiro Katada, Y. Masutani, Kim J. Burchiel, Tetsuo Kanno, G. Palù, Michael Söderman, J.C. Acevedo, Matthew A. Howard, Laurent Launay, G. Antoniadis, Karen Waddell, Y. Lajat, Patrick Mertens, Jin Woo Chang, Ch. Matula, Franck Sturtz, Luis Garcia-Larrea, K. Yamashiro, Igor O. Volkov, Carl-Olav Stiller, Y. Yoshii, D. Hellwig, Olof Flodmark, Jian-Guo Cui, Ruth Govrin-Lippmann, Mark A. Granner, Philip L. Gildenberg, W. Wagner, Joon Hyong Cho, G. Lanner, A. Cavaggioni, L. Benes, P. Calvi, I. Berry, A. Perneczky, R. Andrews, Michael Knauth, M.R. Gaab, H. Bertalanffy, M. Iwahara, J.R. Schvarcz, P. Shamsgovara, W.Th. Koos, W. Dietrich, Peter McL. Black, Juriy Z. Polonskiy, M. Wallace, C. Vial, Friedrich K. Albert, Serge Bracard, Björn A. Meyerson, Joseph A. Maldjian, Vladimir A. Shoustin, J.P. Ranjeva, P.-Å. Ridderheim, N. Tomiyama, M. Tremoulet, S.A. Rath, Roland Peyron, D. Menegalli-Boggelli, Sang Sup Chung, Jamal M. Taha, Kazuhiko Nonomura, C. Giorgi, Marie-Claude Gregoire, Stefan Kunze, Doros Platika, A. Ishida, M. Daniel Noh, Yong Gou Park, J.H. Song, Vladimir B. Nizkovolos, J. Mukawa, H.W.S. Schroeder, K. Ericson, J. Sabatier, J.F. Kahamba, W. Tschiltschke, O. Alberti, Alf Sollevi, Per Kristian Eide, C.W. Dempsey, Eben Alexander, Ron Kikinis, and R. Deinsberger

Subjects
Transplantation, Pathology, medicine.medical_specialty, business.industry, Genetic enhancement, Medicine, Surgery, Neurology (clinical), business, Bioinformatics
Published
1997
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9. Subject Index Vol. 68, 1997

Author

Nicholas Ayache, Thomas M. Moriarty, G. Antoniadis, Bengt Linderoth, F. Lavenne, Roman Mirsky, Jacques Feldmar, C. Giorgi, Y. Muragaki, Ch. Matula, Michael J. Levy, J.R. Schvarcz, H. Goerzer, T. Taira, K. Ungersboeck, Serge Bracard, Björn A. Meyerson, D.E. Richardson, P. Charles Garell, Marc Sindou, Andrey V. Oblyapin, Audun Stubhaug, N. Hopf, F.E. Roux, E. Blondet, K. Roessler, Sang Sup Chung, Jamal M. Taha, Kazuhiko Nonomura, Igor O. Volkov, C.W. Dempsey, L. Mahfouf, Olof Flodmark, In Ki Mun, Tetsuo Kanno, C.R. Wirtz, Volker M. Tronnier, N. Tomiyama, Grégoire Malandain, W. Tschiltschke, N.L. Dorward, Jin Woo Chang, O. Alberti, Y. Terada, Matthew A. Howard, A. Ishida, D. Hellwig, Alf Sollevi, Per Kristian Eide, Andrey D. Anichkov, François Mauguière, Karen Waddell, M. Tremoulet, R. Andrews, Jeffrey Labuz, N.D. Kitchen, Eben Alexander, N. Soliman, A.T. Bergenheim, K. Takakura, Kirk Moffitt, J.H. Song, L. Casentini, M. Daniel Noh, Yong Gou Park, Catherine Fischer, Jacques Favre, Xiaozhuo Chen, Juriy Z. Polonskiy, M. Wallace, C. Vial, Yong Ko, Marshall Devor, Margareta B. Møller, G. Lanner, Blaine S. Nashold, R. Mah, Joseph A. Maldjian, J. Mukawa, D. Albe-Fessard, Kyung Hoe Lee, B. Abdennebi, Ron Kikinis, D.S. Casolino, E. Emery, Peter W. Carmel, C. Manelfe, Ruth Govrin-Lippmann, W. Wagner, Z. Harry Rappaport, P. Calvi, Luis Garcia-Larrea, Krupa Shanker, Eric Maurincomme, H.W.S. Schroeder, A. Perneczky, Y. Yoshii, J. Winters, K. Ericson, Joseph C.T. Chen, Luc Picard, Vadim Yakhnitsa, Mario M. Bonsanto, Michael Söderman, Vladimir B. Nizkovolos, Bernard Laurent, Vladimir A. Shoustin, J. Sabatier, I. Berry, Michael Schulder, H. Iseki, P.-Å. Ridderheim, Andreas Staubert, J.F. Kahamba, M.C. Spendel, Wen-Ching Liu, Erwan Kerrien, F. Colombo, K. Yamashiro, S.A. Rath, H. Bertalanffy, D.G.T. Thomas, A. Cavaggioni, R. Deinsberger, W.Th. Koos, P. Shamsgovara, J.P. Ranjeva, K. Seitz, Michael Knauth, Y. Lajat, Franck Sturtz, M. Zanusso, W. Dietrich, Friedrich K. Albert, L. Benes, Marie-Claude Gregoire, Stefan Kunze, William T. O'Connor, Peter McL. Black, René Anxionnat, Roland Peyron, D. Menegalli-Boggelli, Kazuhiro Katada, Joon Hyong Cho, Märta Segerdahl, M. Iwahara, Arcady V. Korzenev, M. Guerrero, Dennis E. Bullard, Doros Platika, Ferenc M. Jolesz, Laurent Launay, Kim J. Burchiel, H.-P. Richter, Th. Czech, Janine Shulok, Chul-Won Park, P. Grunert, Y. Masutani, Carl-Olav Stiller, A. Galvagni, Philip L. Gildenberg, M.R. Gaab, Mark A. Granner, K. Boulanouar, T. Dohi, M. Aichholzer, B.L. Bauer, T. Tanikawa, Jian-Guo Cui, Frédéric Bonnefoi, T. Nedjahi, W.R. Niendorf, R.R. Tasker, D. Heyman, J.C. Acevedo, E. Franchin, G. Palù, H. Ralph Snodgrass, Patrick Mertens, and R. Papasin

Subjects
medicine.medical_specialty, Index (economics), business.industry, Medicine, Surgery, Subject (documents), Medical physics, Neurology (clinical), business
Published
1997
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