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457 results on '"Roman, MJ"'

1. Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in american indians: The strong heart family study

Author

Blackburn, Elizabeth, Chen, S, Lin, J, Matsuguchi, T, Yeh, F, Best, LG, Devereux, RB, Lee, ET, Howard, BV, and Roman, MJ

Abstract

Short leukocyte telomere length (LTL) has been associated with atherosclerosis in cross-sectional studies, but the prospective relationship between telomere shortening and risk of developing carotid atherosclerosis has not been wellestablished. This study

Published
2014

2. Paleoflora y Paleovegetación Ibérica III: Holoceno

Author

Carrión, José, Lopez-Saez, Ja, Casas-Gallego, M, Gonzalez-Samperiz, P, Badal, E, Perez-Diaz, S, Carrion-Marco, Y, Jimenez-Moreno, G, Lopez-Merino, L, Burjachs, F, Abel-Schaad, D, Fernandez, S, Morales-Molino, C, Alba Sanchez, F, Peña-Chocarro, L, Barron, E, Postigo-Mijarra, Jm, Gil-Garcia, Mj, Rubiales, Jm, Vidal-Matutano, P, Arambarri, J, Ramos-Roman, Mj, Camuera, J, Magri, D, Revelles, J, Altolaguirre, Y, Ruiz-Zapata, B, Luelmo, R, Uzquiano, P, Allue, E, Anderson, S, Dupre, M, Gil-Romera, G, Pique, R, Garcia-Anton, M, Amoros, G, Yll, R, Perez-Jorda, G, Scott, L, Figueiral, I, Rodriguez-Ariza, Mo, Morla-Jauristi, C, Garcia-Amorena, I, Montoya, E, Val Peon, C, Ejarque, A, Riera, S, Peñalba, C, Fierro, E, Exposito, I, Perez-Obiol, R, Vieira, M, Gomez-Manzaneque, F, Maldonado, J, Leunda, M, Franco, F, Albert, Rm, Diez, Mj, Marin-Arroyo, Ab, Manzano, S, Dirita, F, Andrade, A, Parra, I, Zapata, L, Perez, A, Grau, E, Alcolea, M, Mesa-Fernandez, Jm, Miras, Y, Ruiz-Alonso, M, Genova, M, Garcia-Alvarez, S, Moreno, E, Olmedo Cobo, Ja, Gomez Zotano, J, Pardo Martinez, R, Mas, B, Monteiro, P, Antolin, F, Obea, L, Martin-Seijo, M, Alonso, N, Amoros, A, Fernandez-Diaz, M, Reyes, Pp, Sanchez-Giner, V, Gomez-Rodriguez, M, Rull, V, Vegas-Villarrubia, T, Lopez-Bulto, O, Bianco, S, Trapote, Mc, Picornell-Gelabert, L, Sureda, P, BRISSET, Elodie, Servera Vives, G, Girona, A, Celant, A., Munuera, M, Ochando, J, Brisset, E, Universidad de Murcia, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), and Ministerio de Ciencia e Innovación y Fundación Séneca

Subjects
Holocene, [SDE]Environmental Sciences, Paleoflora, Holoceno, Iberia Peninsula
Abstract

International audience

Published
2022

9. Cardiovascular Phenotype in Sarcopenic Obesity

Author

DE SIMONE, GIOVANNI, PASANISI, FABRIZIO, FERRARA, LIBERATO ALDO, CONTALDO, FRANCO, Roman MJ, Lee ET, Howard BV, Devereux RB, DE SIMONE, Giovanni, Pasanisi, Fabrizio, Ferrara, LIBERATO ALDO, Roman, Mj, Lee, Et, Contaldo, Franco, Howard, Bv, and Devereux, Rb

Published
2010

17. Relation among lipoprotein subfractions and carotid atherosclerosis in Alaskan Eskimos (from the Gogadan Study)

Author

MASULLI, MARIA, PATTI, LIDIA, RICCARDI, GABRIELE, VACCARO, OLGA, ANNUZZI, GIOVANNI, RIVELLESE, ANGELA ALBAROSA, Ebbesson SO, Fabsitz RR, Howard WJ, Otvos JD, Roman MJ, Wang H, Weissman NJ, Howard BV, Masulli, Maria, Patti, Lidia, Riccardi, Gabriele, Vaccaro, Olga, Annuzzi, Giovanni, Ebbesson, So, Fabsitz, Rr, Howard, Wj, Otvos, Jd, Roman, Mj, Wang, H, Weissman, Nj, Howard, Bv, and Rivellese, ANGELA ALBAROSA

Subjects
Relation among lipoprotein
Published
2009

29. Impact of obesity on cardiac geometry and function in a population of adolescents: the Strong Heart Study

Author

CHINALI, MARCELLO, DE SIMONE, GIOVANNI, ROMAN MJ, LEE ET, BEST LG, HOWARD BV, DEVEREUX RB, Chinali, Marcello, DE SIMONE, Giovanni, Roman, Mj, Lee, Et, Best, Lg, Howard, Bv, and Devereux, Rb

Abstract

OBJECTIVES: The goal here was to examine left ventricular (LV) geometry and function in a large, unselected group of adolescents with different degrees of abnormal body build, and verify whether possibly higher LV mass is compensatory for increased cardiac workload. BACKGROUND: There is little information on how much the excess of body weight impacts LV geometry and function in populations of adolescents. METHODS: Anthropometric, laboratory, and Doppler echocardiographic parameters of cardiac geometry and function were obtained in 460 adolescent participants (age 14 to 20 years, 245 female participants, 27 hypertensive, 10 with diabetes) from the Strong Heart Study. Body build was classified based on 85th and 95th percentiles of body mass index (BMI)-for-age charts. RESULTS: Range of BMI was 16.3 to 56.5 kg/m2 (28.8 +/- 8.3 kg/m2); 114 participants (24.9%) fell within the 85th percentile of BMI distribution (normal weight [NW]), 113 (24.6%) fell between 85th and 95th percentile (overweight [OW]), and 223 (48.5%) fell above the 95th percentile (obese [OB]). Obese participants were older than OW and NW subjects (p < 0.01), without differences in heart rate. Both OW and OB had greater LV diameter and mass than NW (all p < 0.05). Left ventricular hypertrophy was more prevalent in the OB (33.5%) and OW (12.4%), as compared with NW participants (3.5%; p < 0.001), largely compensating increased cardiac workload. However, OB subjects had four-fold higher probability of carrying an LV mass exceeding values compensatory for their cardiac workload (p < 0.001), a feature associated with lower ejection fraction, myocardial contractility, and greater force developed by left atrium to complete LV filling (all p < 0.05). CONCLUSIONS: While in OW adolescents increased levels of LV mass are appropriate to compensate their higher hemodynamic load, in OB increase in LV mass exceeds this need and is associated with mildly reduced LV myocardial performance and increased left atrial force to contribute to LV filling.

Published
2006

39. Relation of Age to Left Ventricular Structure, Function, and Systemic Hemodynamics in Normotensive and Hypertensive Employed Adults

Author

Aldrich HA, Roman MJ, Alderman MH, Devereux RB, DE SIMONE, GIOVANNI, Aldrich, Ha, Roman, Mj, DE SIMONE, Giovanni, Alderman, Mh, and Devereux, Rb

Abstract

To determine the effect of age on left ventricular status and systemic hemodynamics, we evaluated by echocardiogram older (age at or above 60 years, n equals 148) and younger (age is less than 60 years, n equals 472) employed adults. Using World Health Organization criteria, the population was divided into the following blood pressure strata: normotensive (n equals 142), borderline hypertensive (n equals 194), and sustained hypertensive (n equals 284). Older subjects were compared to younger subjects in each blood pressure stratum. Older subjects with borderline hypertension and sustained hypertension had a higher systolic blood pressure and wider pulse pressure than younger individuals. Older subjects with borderline hypertension had higher left ventricular mass index (106.7Â+/-28.7 vs 93.9Â+/-22.4, P equals 0.03), and greater wall thicknesses and relative wall thicknesses than younger subjects. Older borderline hypertensive patients had greater left ventricular wall thicknesses and mass, but closely resembled both age groups of sustained hypertensive patients in this regard. Older and younger individuals with borderline hypertension had similar mean cardiac outputs, stroke volumes, and peripheral resistances. In contrast, older patients with sustained hypertension had a lower stroke volume, stroke volume index, cardiac output, cardiac index, and fractional shortening, and a higher total peripheral resistance than their younger counterparts. There were no significant relations between age and any echocardiographic measurement in normotensive subjects. Borderline hypertensive individuals exhibited weak relationships between age and left ventricular wall thicknesses (r equals 0.17; 23) and left ventricular internal dimensions (r equals -0.19 and -0.21). Very weak negative relationships were identified between age and cardiac output for both hypertensive groups. In conclusion, increasing age had relatively little effect on cardiac status in either normotensive or sustained hypertensive employed adults, but was associated with greater left ventricular hypertrophy among individuals with borderline hypertension according to the World Health Organization classification. These results are consistent with the independent value of age and left ventricular mass as predictors of hypertensive complications, but also suggest that under some circumstances, greater age or longer exposure to hypertension may magnify the target-organ effects at a given degree of blood pressure elevation.

Published
1992

40. Central blood pressure measurements and antihypertensive therapy a consensus document

Author

Agabiti Rosei, E, Mancia, G, O'Rourke, M, Roman, M, Safar, M, Smulyan, H, Wang, J, Wilkinson, I, Williams, B, Vlachopoulos, C, O'Rourke, MF, Roman, MJ, Safar, ME, Wang, JG, Wilkinson, IB, Vlachopoulos, C., MANCIA, GIUSEPPE, Agabiti Rosei, E, Mancia, G, O'Rourke, M, Roman, M, Safar, M, Smulyan, H, Wang, J, Wilkinson, I, Williams, B, Vlachopoulos, C, O'Rourke, MF, Roman, MJ, Safar, ME, Wang, JG, Wilkinson, IB, Vlachopoulos, C., and MANCIA, GIUSEPPE

Abstract

The 2003 European Society of Hypertension/European Society of Cardiology guidelines for the management of arterial hypertension1 included 2 important novel recommendations: assessment of the total cardiovascular risk should be taken into account in the management of the hypertensive patient, and quantification of risk should include subclinical target organ damage. These guidelines acknowledged that central (aortic) blood pressure (BP), which is the pressure exerted on the heart and brain, may be different from the pressure that is measured at the arm. They also recognized that central pressure may be predictive of outcome in specific populations2 and differently affected by antihypertensive drugs. However, although these guidelines accepted that central augmentation index and pulse wave velocity may be important as measures of subclinical organ damage, they also stressed the need for prospective trials to establish their predictive values given that such studies were lacking at that time (2003). After publication of these guidelines, additional data have strengthened the pathophysiological importance of central BP. Clinical studies have indicated that central BP may have predictive value independent of the corresponding peripheral (brachial) BP. More importantly, recent large-scale trials have shown that central hemodynamics may provide a worthwhile treatment target. In addition, central hemodynamics can now be reliably assessed noninvasively with a number of devices. Accordingly, because arterial stiffening and central hemodynamics are markers and manifestations of organ damage, the pertinent key question is whether the balance of evidence on their importance and issues related to clinical practice allows for implementation in patient management.

Published
2007

44. Vascular biomarkers in the prediction of clinical cardiovascular disease: the Strong Heart Study.

Author

Roman MJ, Kizer JR, Best LG, Lee ET, Howard BV, Shara NM, Devereux RB, Roman, Mary J, Kizer, Jorge R, Best, Lyle G, Lee, Elisa T, Howard, Barbara V, Shara, Nawar M, and Devereux, Richard B

Abstract

We compared the ability of separately measured intimal-medial thickness and atherosclerotic plaque to predict incident cardiovascular disease. American Indian men and women from the Strong Heart Study who were free of cardiovascular disease were evaluated with carotid ultrasound and cardiovascular disease risk factor assessment. End-diastolic intimal-medial thickness of the common carotid arteries was measured and averaged. Arterial mass (cross-sectional area) was calculated from intimal-medial thickness and end-diastolic diameter. Atherosclerosis was defined by focal plaque (discrete thickening >50% relative to the adjacent wall) and the number of carotid segments containing plaque (plaque score); 2441 participants (age 63±8 years) were followed-up for a mean of 7.7±2.8 years, during which time 495 experienced incident cardiovascular disease events. Time-to-event analyses were performed in groups stratified according to diabetes and hypertension status. Cardiovascular disease events were predicted by presence and extent of atherosclerosis in all groups; intima-medial thickness and arterial mass were only associated with outcomes when neither hypertension nor diabetes was present. Unequivocal evidence of atherosclerosis (plaque) and its extent (plaque score) are independently associated with incident cardiovascular disease events in individuals without preexisting cardiovascular disease regardless of diabetes and hypertension status. Hypertension-related increases in intima-media thickness and arterial mass appear to limit their use as measures of early or diffuse atherosclerosis and, hence, association with cardiovascular disease outcomes. These findings support the utility of separate assessment of focal atherosclerosis and intimal-medial thickness in epidemiological studies, trials, and risk stratification protocols. [ABSTRACT FROM AUTHOR]

Published
2012
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45. Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study.

Author

De Marco M, de Simone G, Roman MJ, Chinali M, Lee ET, Calhoun D, Howard BV, Devereux RB, De Marco, Marina, de Simone, Giovanni, Roman, Mary J, Chinali, Marcello, Lee, Elisa T, Calhoun, Darren, Howard, Barbara V, and Devereux, Richard B

Abstract

Objective: The aim of this study was to evaluate whether diabetes (DM) and impaired fasting glucose (IFG) were associated with early alterations in left ventricular geometry and function in a large population of adolescents and young adults independently of major confounders.Research Design and Methods: We analyzed echocardiographic data of 1,624 14- to 39-year-old participants (mean age 26.6 ± 7.7 years; 57% female) without prevalent cardiovascular disease from the fourth Strong Heart Study examination; 179 (11%) participants had DM and 299 (18%) had IFG.Results: Participants with DM and IFG were older and more often obese and hypertensive than participants with normal fasting glucose (NFG) (all P < 0.05). After adjustment for age, sex, systolic blood pressure, and body fat, diabetic and IFG participants had higher left ventricular mass index than those with NFG (41.5 ± 8.7 and 39.6 ± 9.2 vs. 35.6 ± 7.8 g/m(2.7)) and reduced stress-corrected midwall shortening (98 ± 8.6 and 99 ± 7.5 vs. 101 ± 8.5%; all P < 0.05). The prevalence of left ventricular hypertrophy was higher in DM (20%) and IFG (17%) than in NFG participants (12%; P < 0.05). Compared with the other groups, DM was also associated with higher prevalence of inappropriate left ventricular mass, concentric geometry, and more diastolic abnormalities independently of covariates (all P < 0.05).Conclusions: In a population of adolescents and young adults, DM is independently associated with early unfavorable cardiovascular phenotype characterized by increased left ventricular mass, concentric geometry, and early preclinical systolic and diastolic dysfunction; early cardiovascular alterations are also present in participants with prediabetes. [ABSTRACT FROM AUTHOR]

Published
2011
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48. High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart study.

Author

Roman MJ, Devereux RB, Kizer JR, Okin PM, Lee ET, Wang W, Umans JG, Calhoun D, Howard BV, Roman, Mary J, Devereux, Richard B, Kizer, Jorge R, Okin, Peter M, Lee, Elisa T, Wang, Wenyu, Umans, Jason G, Calhoun, Darren, and Howard, Barbara V

Abstract

Objectives: This study was designed to facilitate clinical use of central pulse pressure (PP). We sought to determine a value that might predict adverse outcome and thereby provide a target for assessment of intervention strategies.Background: We previously documented that central PP more strongly relates to carotid hypertrophy and extent of atherosclerosis and, more importantly, better predicts incident cardiovascular disease (CVD) than brachial PP.Methods: Radial applanation tonometry was performed in the third Strong Heart Study examination to determine central blood pressure. Cox regression analyses were performed using pre-specified covariates and quartiles of central and brachial PP.Results: Among 2,405 participants without prevalent CVD, 344 suffered CVD events during 5.6 +/- 1.7 years. Quartiles of central PP (p < 0.001) predicted outcome more strongly than quartiles of brachial PP (p = 0.052). With adjustment for covariates, only the event rate in the fourth quartile of central PP (> or =50 mm Hg) was significantly higher than that in the first quartile (hazard ratio [HR]: 1.69, 95% confidence interval [CI]: 1.20 to 2.39, p = 0.003). Central PP > or =50 mm Hg was related to outcome in both men (HR: 2.06, 95% CI: 1.39 to 3.04, p < 0.001) and women (HR: 2.03, 95% CI: 1.55 to 2.65, p < 0.001); in participants with (HR: 1.84, 95% CI: 1.41 to 2.39, p < 0.001) and without diabetes (HR: 1.91, 95% CI: 1.29 to 2.83, p = 0.001); and in individuals younger (HR: 2.51, 95% CI: 1.59 to 3.95, p < 0.001) and older (HR: 1.53, 95% CI: 1.19 to 1.97, p = 0.001) than the age of 60 years.Conclusions: Central PP > or =50 mm Hg predicts adverse CVD outcome and may serve as a target in intervention strategies if confirmed in other populations and in prospective studies. [ABSTRACT FROM AUTHOR]

Published
2009
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