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3. Machine Learning and Glioblastoma: Treatment Response Monitoring Biomarkers in 2021

Author

Booth, Thomas, Akpinar, Bernice, Roman, Andrei, Shuaib, Haris, Luis, Aysha, Chelliah, Alysha, Busaidi, Ayisha Al, Mirchandani, Ayesha, Alparslan, Burcu, Mansoor, Nina, Ashkan, Keyoumars, Ourselin, Sebastien, and Modat, Marc

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning
Abstract

The aim of the systematic review was to assess recently published studies on diagnostic test accuracy of glioblastoma treatment response monitoring biomarkers in adults, developed through machine learning (ML). Articles were searched for using MEDLINE, EMBASE, and the Cochrane Register. Included study participants were adult patients with high grade glioma who had undergone standard treatment (maximal resection, radiotherapy with concomitant and adjuvant temozolomide) and subsequently underwent follow-up imaging to determine treatment response status. Risk of bias and applicability was assessed with QUADAS 2 methodology. Contingency tables were created for hold-out test sets and recall, specificity, precision, F1-score, balanced accuracy calculated. Fifteen studies were included with 1038 patients in training sets and 233 in test sets. To determine whether there was progression or a mimic, the reference standard combination of follow-up imaging and histopathology at re-operation was applied in 67% of studies. The small numbers of patient included in studies, the high risk of bias and concerns of applicability in the study designs (particularly in relation to the reference standard and patient selection due to confounding), and the low level of evidence, suggest that limited conclusions can be drawn from the data. There is likely good diagnostic performance of machine learning models that use MRI features to distinguish between progression and mimics. The diagnostic performance of ML using implicit features did not appear to be superior to ML using explicit features. There are a range of ML-based solutions poised to become treatment response monitoring biomarkers for glioblastoma. To achieve this, the development and validation of ML models require large, well-annotated datasets where the potential for confounding in the study design has been carefully considered.

Published
2021
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5. Lung Cancer in Romania.

Author

Olteanu, Gheorghe-Emilian, Vigdorovits, Alon, Barna, Robert Alexandru, Mazilu, Laura, Manolache, Veronica, Preoteasa, Vladimir, Curcean, Sebastian, Roman, Andrei, Motas, Natalia, Dediu, Mircea, and Ionescu, Diana N.

Published
2024
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6. SERS-based DNA methylation profiling allows the differential diagnosis of malignant lymphadenopathy

Author

Stefancu, Andrei, Moisoiu, Vlad, Desmirean, Minodora, Iancu, Stefania D., Tigu, Adrian B., Petrushev, Bobe, Jurj, Ancuta, Cozan, Ramona G., Budisan, Liviuta, Fetica, Bogdan, Roman, Andrei, Dobie, Gina, Turcas, Cristina, Zdrenghea, Mihnea, Teodorescu, Patric, Pasca, Sergiu, Piciu, Doina, Dima, Delia, Bálint, Zoltán, Leopold, Nicolae, and Tomuleasa, Ciprian

Published
2022
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7. Machine Learning and Glioblastoma: Treatment Response Monitoring Biomarkers in 2021

Author

Booth, Thomas C., Akpinar, Bernice, Roman, Andrei, Shuaib, Haris, Luis, Aysha, Chelliah, Alysha, Al Busaidi, Ayisha, Mirchandani, Ayesha, Alparslan, Burcu, Mansoor, Nina, Ashkan, Keyoumars, Ourselin, Sebastien, Modat, Marc, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kia, Seyed Mostafa, editor, Mohy-ud-Din, Hassan, editor, Abdulkadir, Ahmed, editor, Bass, Cher, editor, Habes, Mohamad, editor, Rondina, Jane Maryam, editor, Tax, Chantal, editor, Wang, Hongzhi, editor, Wolfers, Thomas, editor, Rathore, Saima, editor, and Ingalhalikar, Madhura, editor

Published
2020
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8. CT Angiography-Guided Needle Insertion for Interstitial Brachytherapy in Locally Advanced Cervical Cancer.

Author

Kirsch-Mangu, Alexandra Timea, Pop, Diana Cristina, Tipcu, Alexandru, Andries, Alexandra Ioana, Pasca, Gina Iulia, Fekete, Zsolt, Roman, Andrei, Irimie, Alexandru, and Ordeanu, Claudia

Subjects
INTERSTITIAL brachytherapy, CERVICAL cancer, ARTERIAL puncture, NEEDLES & pins, ANGIOGRAPHY
Abstract

CT angiography might be a suitable procedure to avoid arterial puncture in combined intracavitary and interstitial brachytherapy for cervical cancer curatively treated with combined chemoradiation and brachytherapy boost. Data in the literature about this technique are scarce. We introduced this method and collected brachytherapy data from patients treated in our department between May 2021 and April 2024. We analyzed the applicator subtype, needle insertion (planned versus implanted), implanted depth and the role of CT angiography in selecting needle trajectories and insertion depths. None of the patients managed through this protocol experienced atrial puncture and consequent hemorrhage. Needle positions were accurately selected with the aid of CT angiography with proper coverage of brachytherapy targets and avoidance of organs at risk. CT angiography is a promising method for guiding needle insertion during interstitial brachytherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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12. #746 Molecular analysis of BRCA and hrd status from small biopsies in high grade serous carcinoma. a real-world comparative analysis

Author

Kubelac, Paul, primary, Avram, Anca, additional, Turcas, Adrian, additional, Roman, Andrei, additional, Piciu, Andra, additional, Pasca, Andrei, additional, Gata, Vlad, additional, Tripac, Irina, additional, Pop, Bogdan, additional, Balacescu, Ovidiu, additional, Vlad, Catalin, additional, and Achimas-Cadariu, Patriciu, additional

Published
2023
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13. Machine Learning and Glioblastoma: Treatment Response Monitoring Biomarkers in 2021

Author

Booth, Thomas C., primary, Akpinar, Bernice, additional, Roman, Andrei, additional, Shuaib, Haris, additional, Luis, Aysha, additional, Chelliah, Alysha, additional, Al Busaidi, Ayisha, additional, Mirchandani, Ayesha, additional, Alparslan, Burcu, additional, Mansoor, Nina, additional, Ashkan, Keyoumars, additional, Ourselin, Sebastien, additional, and Modat, Marc, additional

Published
2020
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14. Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase.

Author

Moretti, Ana Iochabel Soares, Baksheeva, Viktoria E., Roman, Andrei Yu., De Bessa, Tiphany Coralie, Devred, François, Kovacic, Hervé, and Tsvetkov, Philipp O.

Subjects
PROTEIN disulfide isomerase, ZINC ions, PROTEIN stability, ISOTHERMAL titration calorimetry, ISOMERASES, DIFFERENTIAL scanning calorimetry, ZINC-finger proteins
Abstract

The interplay between metal ion binding and the activity of thiol proteins, particularly within the protein disulfide isomerase family, remains an area of active investigation due to the critical role that these proteins play in many vital processes. This research investigates the interaction between recombinant human PDIA1 and zinc ions, focusing on the subsequent implications for PDIA1's conformational stability and enzymatic activity. Employing isothermal titration calorimetry and differential scanning calorimetry, we systematically compared the zinc binding capabilities of both oxidized and reduced forms of PDIA1 and assessed the structural consequences of this interaction. Our results demonstrate that PDIA1 can bind zinc both in reduced and oxidized states, but with significantly different stoichiometry and more pronounced conformational effects in the reduced form of PDIA1. Furthermore, zinc binding was observed to inhibit the catalytic activity of reduced-PDIA1, likely due to induced alterations in its conformation. These findings unveil a potential regulatory mechanism in PDIA1, wherein metal ion binding under reductive conditions modulates its activity. Our study highlights the potential role of zinc in regulating the catalytic function of PDIA1 through conformational modulation, suggesting a nuanced interplay between metal binding and protein stability in the broader context of cellular redox regulation. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Mammographic assessment of breast density as a tool for predicting the response to neoadjuvant therapy in breast cancer patients.

Author

Lisencu, Lorena Alexandra, Roman, Andrei, Pașca, Andrei, Irimie, Alexandru, Lisencu, Cosmin, Negrutiu, Mircea, Fetica, Bogdan, Cismaru, Andrei, Balacescu, Ovidiu, Tudoran, Oana, and Lisencu, Carmen

Subjects
*BREAST, *NEOADJUVANT chemotherapy, *CANCER patients, *BREAST cancer, *CANCER treatment, *PROGNOSIS
Abstract

Background and aims. Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide. For locally advanced diseases and high-risk tumors, neoadjuvant therapy (NAT) is the treatment of choice. Some studies show that mammographic density (MD) tumor margins and the presence of microcalcifications play a prognostic role in BC patients. Hence, the objective of this retrospective study was to assess if MD could predict the response to NAT among different molecular subtypes of BC patients undergoing NAT at The "Prof. Dr I. Chiricuta" Oncology Institute of Cluj-Napoca, Romania (IOCN). Furthermore, the association between MD, tumor margins and the presence of microcalcifications with clinico-pathological data was analyzed. Methods. Eighty-four breast cancer patients diagnosed and treated at IOCN were included in this study. The morphological characteristics of the tumors were framed according to the BIRADS lexicon. The presence or absence of microcalcifications was also assessed. First, the significance of associations between breast density, margins and microcalcifications and clinico-pathological parameters of the patients were tested with Fisher or Fisher-Freeman-Halton Exact Test. Next, using multinomial logistic regression, we modelled the associations between the pathological response measured by Miller Payne and Residual cancer burden (RCB) systems and the BIRADS. Variables having significant univariate tests were selected as candidates for the multivariable analysis (adjusted model). Results. Breast densities were significantly associated with the age of the patients (p=0.01), number of positive lymph nodes (p=0.037), margins (p=0.002) and combined categories of Miller-Payne (p=0.034) and RCB pathological response (p=0.021). Margins was significantly associated with ki67 proliferation index (p=0.029), estrogen receptor (ER) (p=0.007), progesterone receptor (PR) (p=0.019), molecular subtype (p<0.001) and the number of clinically observed positive lymph nodes at diagnosis (p=0.019). Conclusions. In our cohort, BC patients with lower MD had higher odds of achieving pCR following NAT, suggesting the role of MD as a clinical prognostic marker. Larger multicenter studies are warranted to validate the prognostic value of MD, which could aid in patients stratification based on their likelihood to respond to NAT. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Gamma-Synuclein Dysfunction Causes Autoantibody Formation in Glaucoma Patients and Dysregulation of Intraocular Pressure in Mice

Author

Pavlenko, Tatiana A., primary, Roman, Andrei Y., additional, Lytkina, Olga A., additional, Pukaeva, Nadezhda E., additional, Everett, Martha W., additional, Sukhanova, Iuliia S., additional, Soldatov, Vladislav O., additional, Davidova, Nina G., additional, Chesnokova, Natalia B., additional, Ovchinnikov, Ruslan K., additional, and Kukharsky, Michail S., additional

Published
2022
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22. Overcoming challenges of translating deep-learning models for glioblastoma:the ZGBM consortium

Author

Haris, Shuaib, Gareth J, Barker, Peter, Sasieni, Enrico, De Vita, Alysha, Chelliah, Roman, Andrei, Keyoumars, Ashkan, Erica, Beaumont, Lucy, Brazil, Chris, Rowland-Hill, Andrea, Lau, Aysha, Luis, James, Powell, Angela, Swampillai, Sean, Tenant, Stefanie C, Thust, Stephen, Wastling, Tom, Young, Thomas Calvert, Booth, Juliet, Brock, Stuart, Currie, Kavi, Fatani, Karen, Foweraker, Jennifer, Glendenning, Nigel, Hoggard, Avinash K, Kanodia, Anant, Krishnan, Mark Dv, Thurston, Joanne, Lewis, Christian, Linares, Ryan K, Mathew, Satheesh, Ramalingam, Vijay, Sawlani, Liam, Welsh, and Matt, Williams

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine
Abstract

Objective: To report imaging protocol and scheduling variance in routine care of glioblastoma patients in order to demonstrate challenges of integrating deep-learning models in glioblastoma care pathways. Additionally, to understand the most common imaging studies and image contrasts to inform the development of potentially robust deep-learning models. Methods: MR imaging data were analysed from a random sample of five patients from the prospective cohort across five participating sites of the ZGBM consortium. Reported clinical and treatment data alongside DICOM header information were analysed to understand treatment pathway imaging schedules. Results: All sites perform all structural imaging at every stage in the pathway except for the presurgical study, where in some sites only contrast-enhanced T1-weighted imaging is performed. Diffusion MRI is the most common non-structural imaging type, performed at every site. Conclusion: The imaging protocol and scheduling varies across the UK, making it challenging to develop machine-learning models that could perform robustly at other centres. Structural imaging is performed most consistently across all centres. Advances in knowledge: Successful translation of deep-learning models will likely be based on structural post-treatment imaging unless there is significant effort made to standardise non-structural or peri-operative imaging protocols and schedules.

Published
2023

27. The interrelation between otorhinolaryngology and orthodontics in solving malocclusion and facial dysmorphisms caused by chronic adenotonsillitis

Author

Cobzeanu, Bogdan Mihail, primary, Palade, Dragos Octavian, additional, Bandol, Gianina, additional, Rusu, Daniela, additional, Severin, Florentina, additional, Rosu, Andrei, additional, Roman, Andrei, additional, Vlad, Andreea, additional, Mocanu, Florin, additional, Cobzeanu, Mihail Dan, additional, Cobzeanu, Maria Luiza, additional, Zetu, Irina, additional, and Iacob, Mihnea, additional

Published
2022
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28. Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients

Author

Baldasici, Oana, primary, Balacescu, Loredana, additional, Cruceriu, Daniel, additional, Roman, Andrei, additional, Lisencu, Carmen, additional, Fetica, Bogdan, additional, Visan, Simona, additional, Cismaru, Andrei, additional, Jurj, Ancuta, additional, Barbu-Tudoran, Lucian, additional, Pileczki, Valentina, additional, Vlase, Laurian, additional, Tudoran, Oana, additional, and Balacescu, Ovidiu, additional

Published
2022
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29. The Role of miR-375-3p, miR-210-3p and Let-7e-5p in the Pathological Response of Breast Cancer Patients to Neoadjuvant Therapy

Author

Lisencu, Lorena Alexandra, primary, Roman, Andrei, additional, Visan, Simona, additional, Bonci, Eduard-Alexandru, additional, Pașca, Andrei, additional, Grigorescu, Emilia, additional, Mustea, Elena, additional, Cismaru, Andrei, additional, Irimie, Alexandru, additional, Lisencu, Cosmin, additional, Balacescu, Loredana, additional, Balacescu, Ovidiu, additional, and Tudoran, Oana, additional

Published
2022
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30. Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein

Author

Gibbs, Ebrima, primary, Zhao, Beibei, additional, Roman, Andrei, additional, Plotkin, Steven S., additional, Peng, Xubiao, additional, Hsueh, Shawn C. C., additional, Aina, Adekunle, additional, Wang, Jing, additional, Shyu, Clay, additional, Yip, Calvin K., additional, Nam, Sung-Eun, additional, Kaplan, Johanne M., additional, and Cashman, Neil R., additional

Published
2022
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34. Assessing the knowledge, attitudes and practices concerning hormonal emergency contraception among female university students from Cluj-Napoca

Author

Sevastre-Berghian, Alexandra, Hanganu, Daniela, Benedec, Daniela, Oniga, Ilioara, Vlase, Laurian, Baldea, Ioana, Olteanu, Diana, Clichici, Simona, Filip, Gabriela Adriana, Ciocan, Andra, Bolboacă, Sorana D., Ciocan, Răzvan A., Nadim, Al Hajjar, Urda-Cîmpean, Andrada Elena, Pop, Cristina, Horon, Bianca, Mogoşan, Emilia, Cazacu, Irina, Cristina, Anamaria, Voştinaru, Oliviu, Anca, Emilia, Lang, Camelia, Roşioru, Corina, Erhan, Sabina, Vlad, Cristina, Capraş, Roxana-Denisa, Cordoş, Ariana-Anamaria, Blebea, Cristina, Perde-Schrepler, Maria, Bindea, Mihaela, Tatomir, Corina, Ujvary, Peter, Maniu, Alma, Tudor, Diana Valentina, Bâldea, Ioana, Lupu, Mihai, Filip, Adriana Gabriela, Schiotis, Ruxandra Elena, Radu, Catalina, Goşa, Dana, Bocşan, Corina, Buzoianu, Anca Dana, Domşa, Elena-Maria, Mureşan, Adriana, David, Luminiţa, Moldovan, Bianca, Para, Ioana, Negrean, Vasile, Andreica, Vasile, Neag, Maria Adriana, Cătinean, Adrian, Muntean, Dana Maria, Pop, Maria Raluca, Bocşan, Ioana Corina, Boţan, Emil Claudiu, Todea, M., Pop-Mureşan, M., Vulpoi, A., Popa, C., Berce, P., Simon, S., Eniu, D., Pop, Raluca M., Sabin, Octavia, Chedea, Veronica S., Boca, Andreea N., Bocşan, Corina I., Buzoianu, Anca D., Lupean, Roxana-Adelina, Crişan, Maria, Şovrea, Alina Simona, Şuşman, Sergiu Valeriu, Boşca, Adina Bianca, Melincovici, Carmen Stanca, Mărginean, Mariana Viorica, Constantin, Anne-Marie, Jianu, Mihaela Elena, Coneac, Andrei, Mocan, Lavinia Patricia, Moldovan, Ioana-Maria, Sufleţel, Rada Teodora, Mihu, Carmen Mihaela, Sitar-Taut, Adela-Viviana, Cozma, Angela, Orasan, Olga, Fodor, Adriana, Coste, Sorina, Tarmure, Simina, Pop, Dana, Zdrenghea, Dumitru, Sampelean, Dorel, Grosu, Alin, Radulescu, Dan, Grosu, Laura, Buzdugan, Elena, Crisan, Sorin, Maierean, Anca Diana, Todea, Doina Adina, Budin, Corina Eugenia, Maierean, Anca, Alexescu, Teodora, Turcanu, Anca, Semenescu, Raluca, Farcas, Loredana, Rohozneanu, Emanuela, Rădulescu, Dan, Răchişan, Andreea Liana, Dubois, Valerie, Ranchin, Bruno, Leclerc, Anne Laure Sellier, Thomas, Aurelia Bertholet, Cochat, Pierre, Bacchetta, Justine, Sava, Bianca, Mocanu, Lorena, Cismaru, Gabriel, Comsa, Horatiu, Pepine, Diana, Boarescu, Paul, Wasmuth, Alexander, Rosu, Radu, Puiu, Mihai, Gusetu, Gabriel, Condor, Ariana, Crişan, Sorin, Chiorescu, R. M., Barta, A., Mocan, M., Stoia, M. A., Anton, F. P., Mocan-Hognogi, D. L., Goidescu, C. M., Farcaş, A. D., Lazea, Cecilia, Al-Khzouz, Camelia, Bucerzan, Simona, Asavoaie, Carmen, Nascu, Ioana, Grigorescu-Sido, Paula, Sirbe, Claudia, Grigore, Madalina, Negrea, Ana-Georgeta, Suroiu, Sabrina, Borodi, Mihaela, Benta, Gabriel, Delean, Dan, Pop, Tudor L., Grama, Alina, Jianu, Cristian, Itu-Muresan, Corina, Topan, Adriana, Filipescu, Irina, Jianu, Mihaela, Bolboaca, Sorana D., Radulescu, Maria L., Neamti, Lidia, Pop, V., Stoicescu, L., Grosu, A., Radulescu, D., Cîmpianu, Mircea, Blachon, Alexandre, Chiorescu, Roxana, Stoia, Mirela, McPherson, CA, Pop, Sorin, Ruskin, Jeremy, Blendea, Dan, Florian, Teodora-Larisa, Florian, Ioan-Alexandru, Frîngu, Florina, Iosip, Adriana, Tomoaia, Raluca, Gurzau, Diana, Comşa, Horatiu, Caloian, Bogdan, Guşetu, Gabriel, Benţa, Gabriel, Căinap, Simona, Sîrbe, Claudia, Miclea, Diana, Pîrvan, Alexandru, Platon, Monica, Pop, Tudor Lucian, Ciulei, George, Orăşan, Olga Hilda, Coste, Sorina-Cezara, Procopciuc, Lucia Maria, Burac, Lucia, Aldea, Cornel, Bizo, Aurel, Bulata, Bogdan, Fufezan, Otilia, Stefanescu, Horia, Hotea, Ioana, Crisan, Tania O., Pamfil, Cristina, Badii, Medeea, Gaal, Orsolya, Peca, Loredana, Mirea, Andreea, Popp, Radu, Rednic, Simona, Joosten, Leo AB, Gheorghiu, Cristina, Simu, Gelu, Haji-Hassan, Mariam, Perné, Mirela-Georgiana, Milaciu, Mircea Vasile, Sâmpelean, Dorel, Coman, Oana-Maria, Ciumărnean, Lorena, Hăşmăşanu, Monica, Matyas, Melinda, Blaga, Ligia, Bolboacă, Sorana, Zaharie, Gabriela, (Tamaş), Adela Pătcaş, Ciule, Dorina Larisa, Vele, Paulina, Silaghi, Ciprian N., Damian, Laura O., Simon, Siao-Pin, Craciun, Alexandra M., Slavescu, Kinga Cristina, Muresan, Rodica, Mititelu, Alexandra, Tomescu, Serban, Chis, Alexandra Micu, Rednic, Mihaela, Vulturar, Romana, Lazăr, Mădălina, Sas, Valentina, Chiş, Adina, Deleanu, Călin, Man, Sorin, Schnell, Cristina, Nicolescu, Alina, Vinţan, Maria, Poliac, Teodora, Damian, Laura, Romitan, M., Radulescu, Maria, Rădulescu, D., Bădărînză, Maria, Şerban, Oana, Maghea, Lavinia, Papp, Iulia, Guţiu, Roxana-Ioana, Fodor, Daniela, Pirvan, Alexandru, Andrei, Adina, Orasan, Remus Aurel, Orasan, Olga Hilda, Bocşan, Corina Delia, Micu, Mihaela Cosmina, Albu, Adriana, Slavescu, Radu Razvan, Stoicescu, Laurenţiu, Ştefan, Georgia, Bâlteanu, Valentin Adrian, Lauzier, Benjamin, Dhot, Justine, Morgovan, Claudiu, Mogoşan, Cristina, Ghibu, Steliana, Ţaranu, Ioana, Răcătăianu, Nicoleta, Vesa, Ştefan Cristian, Pop, Raluca Maria, Matei, Daniela Maria, Paşca, Sergiu, Buzoianu, Anca-Dana, Acalovschi, Monica, Borz, Mihnea Bogdan, Schitcu, Vlad Horia, Cojocaru, Ion, Marica, Nucu Alexandru, Popescu, Dan Sorin, Munteanu, Vlad Cristian, Borz, Paul Cristian, Rădeanu, D., Dragoş, D., Girbe, S., Gondor, G., Stan, C., Maniu, A., Florian, Ioan-Stefan, Olteanu, G., Radu, M., Tui, I., Andercou, O., Stancu, B., Gherman, Claudia, Constantinescu, Ioana, Mihaileanu, F., Pintea, Daniela, Muntean, V., Simon, Ioan, Capîlnean, Teodora-Valeria, Fabian, Ovidiu, RăzvanTogănel, Mureşan, Flaviu, Deceanu, Daniel, Măluţan, Andrei Mihai, Puşcaş, Mihaela, Ciortea, Răzvan, Mocan-Hognogi, Radu Florin, Bucuri, Carmen Elena, Rada, Maria, Dudea, Marina, Mihu, Dan, Rada, Maria Patricia, Fetica, Bogdan, Clim, Adelina, Roman, Andrei, Lupan-Mureşan, Eugenia-Maria, Voicescu, George Teo, Popa, Stefania-Anda, Golea, Adela, Nechita, Vlad I., Graur, Florin, Moiş, Emil, Hajjar, Nadim A., Suciu, Viorela-Elena, Ignat, Florin Laurenţiu, Boţan, Emil-Claudiu, Bucuri, Carmen, Lăcan, Sorin-Mihai, Ungur, Ovidiu-Mihai, Stan, Constantin, Rădeanu, Doinel, Ujvary, Laszlo Peter, Blebea, Cristina Maria, Bulac, Luiza, Birta, Daiana, Chirilă, Magdalena, Ciocan, Răzvan, Crişan, Doiniţa, Constantinescu, Dan, Muntean, Valentin, Cozma-Petruţ, Anamaria, Badiu-Tişa, Ioana, Filip, Lorena, Banc, Roxana, Stanciu, Oana, Gavrilaş, Laura, Ciobârcă, Daniela, Hegheş, Codruţa, Miere, Doina, Coman, Fana-Maria, Leonte, Denisa, Brém, Balázs, Tötös, Robert, Zaharia, Valentin, Toma, Alexandra, Casoni, Dorina, Gliga, Laura-Elena, Iacob, Bogdan-Cezar, Bodoki, Ede, Oprean, Radu, Hosu, Oana, Melinte, Gheorghe, Casian, Magdolna, Săndulescu, Robert, Cristea, Cecilia, Cernat, Andreea, Irimes, Maria-Bianca, Györfi, Szabolcs János, Tertiş, Mihaela, Suciu, Maria, Anicăi, Liana, Moldovan, Radu-Cristian, Petrache, Alina, Pralea, Ioana-Ecaterina, Cogălniceanu, Gina, Mitoi, Monica, Iuga, Cristina-Adela, Paşca, Denisia, Morariu, Daniel, Buse, Mihail, Ionescu, Corina, Iuga, Cristina Adela, Pricopie, Andreea-Iulia, Ionuţ, Ioana, Marc, Gabriel, Găină, Luiza Ioana, Vodnar, Dan C., Pîrnău, Adrian, Focşan, Monica, Oniga, Ovidiu, Rus, Iulia, Gug, Ioana, Paşcalău, Violeta, Melean, Bianca, Pall, Emoke, Moldovan, Cristian, Stoian, Adrian-Ioan, Dudaş, Cosmina, Moldovan, Rebeca, Toma, Valentin, Ştiufiuc, Rareş I., Stana, Anca, Moldovan, Cadmiel, Gavan, Alexandru, Dias, Maria Inês, Pereira, Carla, Barros, Lillian, Ferreira, Isabel C.F.R., Mocan, Andrei, Crişan, Gianina, Negoi, Oana-Iuliana, Ispas, Georgiana-Ileana, Muşat, Luiza-Georgiana, Muntean, Andrei-Cătălin, Casian, Tibor, Tomuţă, Ioan, Barbălată, Cristina, Porfire, Alina, Cherfan, Anca, Iurian, Sonia, Tomuta, Ioan, Crişan, Ofelia, Hegheş, Simona-Codruţa, Ardelean, Ana-Valentina, Moisescu, Cristina, Negut, Daniel, Ardelean, Ioan, Crişan, Andrea-Gabriela, Ilyés, Kinga, Rus, Lucia, Muntean, Dana-Maria, Kiss, Bela, Loghin, Felicia, Nicoară, Raul, Ilieş, Maria, Herda, Luciana Maria, Polo, Ester, Dawson, Kenneth A., Giudice, Maria Cristina Lo, (Savencu), Ioana Petruşan, Corzo, Carolina, Salar-Behzadi, Sharareh, Fizeşan, Ionel, Pop, Anca, Iacoviţă, Cristian, Topală, Tamara, Scoruş, Lavinia, Ştiufiuc, Rareş, Lucaciu, Constantin Mihai, Rus, Lucia Maria, Kacso, Irina, Pari, Sergiu, Valica, Vladimir, Uncu, Livia, Ştefan, Maria-Georgia, Kiss, Béla, Mogoşan, Cristina Ionela, Ghibu-Morgovan, Steliana Mihaela, Dinte, Elena, Muntean, Dana, Ilea, Aranka, Miclaus, Viorel, Boşca, Bianca, Rusu, Marius Emil, Fizesan, Ionel, Gheldiu, Ana-Maria, Stefan, Maria Georgia, Mates, Letitia, Georgiu, Carmen, Vostinaru, Oliviu, Popa, Daniela-Saveta, Oroian, Monica, Pop, Diana, Marcovici, Adriana, Bhardwaj, Sandeep, Chiş, Amalia-Andreea, Chiş, Mihaela, Picos, Andrei, Badea, Mîndra, Chifor, Ioana, Rotar, Alina, Picos, Alina Monica, Ciurea, Andreea, Roman, Alexandra, Soancă, Andrada, Condor, Daniela, Micu, Iulia Cristina, Kui, Andreea, Berar, Antonela, Negucioiu, Marius, Chisnoiu, Andrea, Ispas, Ana, Buduru, Smaranda, Băbţan, Anida-Maria, Vesa, Ştefan, Boşca, Bianca Adina, Petrescu, Nausica Bianca, Feurdean, Claudia Nicoleta, Uriciuc, Willi Andrei, Ionel, Anca, Buhăţel, Dan, Sava, Arin, Andrei, Vlad, Câmpian, Radu Septimiu, Breban, Ioana Georgiana, Merfea, Mihai, Delean, Ada Gabriela, Cimpean, Sanda Ileana, Tişler, Corina Elena, Picoş, Andrei, Duncea, Ioana, Picoş, Alina Monica, Festila, Dana, Lazar, Alexandra, Selegean, Oana, Ghergie, Mircea, Ostas, Daniel, Hedesiu, Mihaela, Stan, Horatiu, Florian, Alexandru, Florian, Stefan, Bran, Simion, Dinu, Cristian, Armencea, Gabriel, Manea, Avram, Onisor, Florin, Moldovan (Lazar), Madalina Anca, Vacaras, Sergiu, Muresan, Ovidiu, Roman, Rares Calin, Baciut, Mihaela, Baciut, Grigore, Rotar, Horatiu, Crasnean, Emil, Roman, Raluca, Coclici, Alina, Cristian, Dinu, Ţermure, Dragoş Alexandru, (Dascalu), Laura Rusu, Chifor, Radu, Badea, Iulia, Simu, Meda, Badea, Mindra, Lazar, Adela Cristina, Bel, Lucia, Sarpatoczi, Orsolya, Lacatus, Radu, Taulescu, Marian, Campian, Radu Septimiu, Rusnac, Mara Elena, Gasparik, Cristina, Varvara, Bianca Elena, Dudea, Diana, Aluaş, Maria, Lucaciu, Ondine, Bordea, Roxana, Meşter, Alexandru, Colceriu-Şimon, Ioana Maria, Băciuţ, Mihaela, Ştiufiuc, Rareş Ionuţ, Aghiorghiesei, Alexandra, Ţărmure, Viorica, Hedeşiu, Mihaela, Băciuţ, Grigore, Flueraşu, Mirela, Almăşan, Oana, Iacob, Simona, Zaharia, Alina, Balhuc, Silvia, Constantiniuc, Mariana, Mirica, Ioana-Codruta, Furtos, Gabriel, Fontaine, Veronique, Moldovan, Marioara, Campian, Radu-Septimiu, Cadar, Mihai, Fluerasu, Mirela, Almasan, Oana, Sbuciumelea, Ioana, Roman, Raluca A., Ioani, Cosmin-Adrian, Părăian, Alexandra-Mirela, Suciu, Raluca, Ban, Alina, Iozon, Sofia, Şoancă, Andrada, Stoia, Sebastian, Tamaş, Tiberiu, Mitre, Ileana, Rotaru, Horaţiu, Crişan, Liana, Crişan, Bogdan, Onişor, Florin, Roman, Rareş, Mureşan, Ovidiu, Moldovan, Mădălina, Ostaş, Daniel, Almăşan, Horea, Simu, Meda-Romana, Carlot, Clémentine, Ghiran, Raluca, Lupse, Irina, Cosma, Lavinia, and Muntean, Alexandrina

Subjects
physical streiss, Medical Sciences, subclinical atherosclerosis, composite materials, fetal outcome, Pharmacy, cortisol, mechanical properties, Rhodiola Rosea, Surgical Specialties, citrus, smoking, physical training, stress, Abstracts, carotid intima- media thickness, cycle ergometer, insulin resistance, salivary pH, heart rate, oxidative stress, music, shade system, Dental Medicine, flowable resin composites, hypoxia, visceral fat thickness, Basic Sciences, modulus of elasticity, indirect aesthetic reconstruction, PubMed filters, anxiety, inflammation, cocoa, Pharmaceutical Specialties, Medicine, neuroprotection, fatigue, memantine, non-alcoholic steatohepatitis, pregnancy, Fundamental Research, hypothermia, physical effort
Published
2019

36. Imaging Biomarkers of Glioblastoma Treatment Response: A Systematic Review and Meta-Analysis of Recent Machine Learning Studies

Author

Booth, Thomas C., primary, Grzeda, Mariusz, additional, Chelliah, Alysha, additional, Roman, Andrei, additional, Al Busaidi, Ayisha, additional, Dragos, Carmen, additional, Shuaib, Haris, additional, Luis, Aysha, additional, Mirchandani, Ayesha, additional, Alparslan, Burcu, additional, Mansoor, Nina, additional, Lavrador, Jose, additional, Vergani, Francesco, additional, Ashkan, Keyoumars, additional, Modat, Marc, additional, and Ourselin, Sebastien, additional

Published
2022
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37. Mechanism of Zn2+ and Ca2+ Binding to Human S100A1

Author

Baksheeva, Viktoriia E., primary, Roman, Andrei Yu., additional, Villard, Claude, additional, Devred, François, additional, Byrne, Deborah, additional, Yatoui, Dahbia, additional, Zalevsky, Arthur O., additional, Vologzhannikova, Alisa A., additional, Sokolov, Andrey S., additional, Permyakov, Sergei E., additional, Golovin, Andrey V., additional, Shaw, Gary S., additional, Tsvetkov, Philipp O., additional, and Zernii, Evgeni Yu., additional

Published
2021
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38. Gamma-Synuclein Dysfunction Causes Autoantibody Formation in Glaucoma Patients and Dysregulation of Intraocular Pressure in Mice.

Author

Pavlenko, Tatiana A., Roman, Andrei Y., Lytkina, Olga A., Pukaeva, Nadezhda E., Everett, Martha W., Sukhanova, Iuliia S., Soldatov, Vladislav O., Davidova, Nina G., Chesnokova, Natalia B., Ovchinnikov, Ruslan K., and Kukharsky, Michail S.

Subjects
INTRAOCULAR pressure, ALPHA-synuclein, OPEN-angle glaucoma, AUTOANTIBODIES, GLAUCOMA
Abstract

Dysregulation of intraocular pressure (IOP) is one of the main risk factors for glaucoma. γ-synuclein is a member of the synuclein family of widely expressed synaptic proteins within the central nervous system that are implicated in certain types of neurodegeneration. γ-synuclein expression and localization changes in the retina and optic nerve of patients with glaucoma. However, the mechanisms by which γ-synuclein could contribute to glaucoma are poorly understood. We assessed the presence of autoantibodies to γ-synuclein in the blood serum of patients with primary open-angle glaucoma (POAG) by immunoblotting. A positive reaction was detected for five out of 25 patients (20%) with POAG. Autoantibodies to γ-synuclein were not detected in a group of patients without glaucoma. We studied the dynamics of IOP in response to IOP regulators in knockout mice (γ-KO) to understand a possible link between γ-synuclein dysfunction and glaucoma-related pathophysiological changes. The most prominent decrease of IOP in γ-KO mice was observed after the instillation of 1% phenylephrine and 10% dopamine. The total protein concentration in tear fluid of γ-KO mice was approximately two times higher than that of wild-type mice, and the activity of neurodegeneration-linked protein α2-macroglobulin was reduced. Therefore, γ-synuclein dysfunction contributes to pathological processes in glaucoma, including dysregulation of IOP. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Ibrutinib Monotherapy as Bridge-to-Transplant for Relapsed/Refractory Primary Oculo-Cerebral Lymphoma

Author

Deak-Mihaly, Dalma, primary, Iluta, Sabina, additional, Pasca, Sergiu, additional, Jitaru, Ciprian, additional, Roman, Andrei, additional, Andries, Alexandra, additional, Padurariu-Covit, Monica, additional, Petrushev, Bobe, additional, Vasilache, Anca, additional, Bojan, Anca, additional, Zdrenghea, Mihnea, additional, Dascalescu, Angela, additional, Antohe, Ion, additional, Colita, Anca, additional, Colita, Andrei, additional, Dima, Delia, additional, Tanase, Alina, additional, and Tomuleasa, Ciprian, additional

Published
2021
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45. Zinc induces temperature-dependent reversible self-assembly of Tau

Author

Roman, Andrei, Devred, François, Byrne, Deborah, La Rocca, Romain, Ninkina, Natalia, Peyrot, Vincent, Tsvetkov, Philipp, Roman, Andrei Yu., Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Microbiologie de la Méditerranée (IMM), Institute of Physiologically Active Compounds, Russian Academy of Sciences - Chernogolovka, and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
Amyloid, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, chemistry.chemical_element, [SDV.CAN]Life Sciences [q-bio]/Cancer, tau Proteins, Zinc, Polymerization, 03 medical and health sciences, 0302 clinical medicine, Dynamic light scattering, Structural Biology, mental disorders, Humans, Chelation, Binding site, Molecular Biology, 030304 developmental biology, Neurons, 0303 health sciences, Binding Sites, Heparin, Chemistry, Temperature, Neurodegenerative Diseases, Isothermal titration calorimetry, In vitro, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Biophysics, Turbidimetry, Tau, Protein Processing, Post-Translational, Aggregation self - assembly, 030217 neurology & neurosurgery, Intracellular
Abstract

International audience; Tau is an intrinsically disordered microtubule associated protein that is implicated in several neurodegenerative disorders called Tau opathies. In these diseases, Tau is found in the form of intracellular inclusions that consist of aggregated paired helical filaments (PHFs) in neurons. Given the importance of this irreversible PHF formation in neurodegenerative disease, Tau aggregation has been extensively studied. Several different factors, such as mutations or post translational modifications, have been shown to influence the formation of late stage non-reversible Tau aggregates. It was recently shown that zinc ions accelerated heparin induced oligomerization of Tau constructs. Indeed, in vitro studies of PHFs have usually been performed in the presence of additional co-factors, such as heparin, in order to accelerate their formation. Using turbidimetry, we investigated the impact of zinc ions on Tau in the absence of heparin and found that zinc is able to induce a temperature dependent reversible oligomerization of Tau. The obtained oligomers were not amyloid like, and dissociated instantly following zinc chelation or a temperature decrease. Finally, a combination of isothermal titration calorimetry and dynamic light scattering experiments showed zinc binding to a high affinity binding site and three low affinity sites on Tau, accompanied by a change in Tau folding. Altogether, our findings stress the importance of zinc in Tau oligomerization. This newly identified Zn-induced oligomerization mechanism may be a part of a pathway different of and concurrent to Tau aggregation cascade leading to PHF formation.

Published
2019

47. Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding

Author

Tsvetkov, Philipp, Roman, Andrei, Baksheeva, Viktoriia, Nazipova, Aliya, Shevelyova, Marina, Vladimirov, Vasiliy, Buyanova, Michelle, Zinchenko, Dmitry, Zamyatnin, Andrey, Devred, François, Golovin, Andrey, Permyakov, Sergei, Zernii, Evgeni, Roman, Andrei Yu., Zernii, Evgeni Yu., Institut de neurophysiopathologie (INP), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lomonosov Moscow State University (MSU), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Dopamine receptor D2R, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Neuronal calcium sensor-1, Zinc, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, EF-hand motif, Magnesium, Calcium, GRK1, [SDV.CAN]Life Sciences [q-bio]/Cancer, Protein aggregation
Abstract

International audience; Neuronal calcium sensor-1 (NCS-1) protein is abundantly expressed in the central nervous system and retinal neurons, where it regulates many vital processes such as synaptic transmission. It coordinates three calcium ions by EF-hands 2-4, thereby transducing Ca 2+ signals to a wide range of protein targets, including G protein-coupled receptors and their kinases. Here, we demonstrate that NCS-1 also has Zn 2+-binding sites, which affect its structural and functional properties upon filling. Fluorescence and circular dichroism experiments reveal the impact of Zn 2+ binding on NCS-1 secondary and tertiary structure. According to atomic absorption spectroscopy and isothermal titration calorimetry studies, apo-NCS-1 has two high-affinity (4 × 10 6 M −1) and one low-affinity (2 × 10 5 M −1) Zn 2+-binding sites, whereas Mg 2+-loaded and Ca 2+-loaded forms (which dominate under physiological conditions) bind two zinc ions with submicromolar affinity. Metal competition analysis and circular dichroism studies suggest that Zn 2+-binding sites of apo-and Mg 2+-loaded NCS-1 overlap with functional EF-hands of the protein. Consistently, high Zn 2+ concentrations displace Mg 2+ from the EF-hands and decrease the stoichiometry of Ca 2+ binding. Meanwhile, one of the EF-hands of Zn 2+-saturated NCS-1 exhibits a 14-fold higher calcium affinity, which increases the overall calcium sensitivity of the protein. Based on QM/MM molecular dynamics simulations, Zn 2+ binding to Ca 2+-loaded NCS-1 could occur at EF-hands 2 and 4. The high-affinity zinc binding increases the thermal stability of Ca 2+-free NCS-1 and favours the interaction of its Ca 2+-loaded form with target proteins, such as dopamine receptor D2R and GRK1. In contrast, low-affinity zinc binding Frontiers in Molecular Neuroscience | www.frontiersin.org 1

Published
2018

48. The profile of urinary biomarkers in overactive bladder

Author

Rada, Maria Patricia Ciortea, Razvan Malutan, Andrei Mihai and Doumouchtsis, Stergios K. Bucuri, Carmen Elena Clim, Adelina and Roman, Andrei Mihu, Dan

Abstract

Aims In overactive bladder (OAB) research, different biomarkers have been proposed as diagnostic tools and may be used to create individual patient profiles. Assessing the diagnostic performance of biomarkers would better outline their utility. Therefore, our aim was to investigate the diagnostic value of four urinary biomarkers: human brain derived neurotrophic factor (hBDNF), malondialdehyde (MDA), h nerve growth factor (hNGF) and h 8-hydroxydeoxyguanosine in women with OAB. These are neurotrophins/oxidative stress markers that have been linked to lower urinary tract symptoms. Methods A total of 105 women were included in the study and distributed in two groups: a group with OAB (n = 53) and a control group (n = 50). The levels of the biomarkers were determined using enzyme-linked immunosorbent assay technique and they were compared between the groups. If the Mann-Whitney test demonstrated a statistically significant difference, receiver operating curves (ROC) analysis was undertaken. Results When normalized to urinary creatinine, hBDNF, MDA, and hNGF showed significantly increased values in women with OAB as compared to controls, whereas 8-OHdG showed no significant difference. The diagnostic performance of these biomarkers was analyzed based on the area under the ROC curve (AUC). MDA had the highest AUC (0.75), followed by hNGF (0.69) and hBDNF (0.67). Conclusions Our findings suggest that MDA, a relatively novel biomarker in OAB research, has a fair performance as a diagnostic tool for OAB. Moreover, urinary neurotrophins (NGF and BDNF) as biomarkers may have a role in the diagnostic pathways of women with OAB symptoms.

Published
2020

49. A narrative review of central nervous system involvement in acute leukemias

Author

Deak, Dalma, primary, Gorcea-Andronic, Nicolae, additional, Sas, Valentina, additional, Teodorescu, Patric, additional, Constantinescu, Catalin, additional, Iluta, Sabina, additional, Pasca, Sergiu, additional, Hotea, Ionut, additional, Turcas, Cristina, additional, Moisoiu, Vlad, additional, Zimta, Alina-Andreea, additional, Galdean, Simona, additional, Steinheber, Jakob, additional, Rus, Ioana, additional, Rauch, Sebastian, additional, Richlitzki, Cedric, additional, Munteanu, Raluca, additional, Jurj, Ancuta, additional, Petrushev, Bobe, additional, Selicean, Cristina, additional, Marian, Mirela, additional, Soritau, Olga, additional, Andries, Alexandra, additional, Roman, Andrei, additional, Dima, Delia, additional, Tanase, Alina, additional, Sigurjonsson, Olafur, additional, and Tomuleasa, Ciprian, additional

Published
2021
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