657 results on '"Romaguera, D."'
Search Results
2. Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial
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Shyam, Sangeetha, García-Gavilán, J. F., Paz-Graniel, I., Gaforio, J. J., Martínez-González, M. Á., Corella, D., Martínez, J. A., Alonso-Gómez, Á. M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F. J., Lapetra, J., Serra-Majem, J. L., Bueno-Cavanillas, A., Tur, J. A., Sánchez, V. Martín, Pintó, X., Matía-Martín, P., Vidal, J., del Mar Alcarria, M., Daimiel, L., Ros, E., Fernandez-Aranda, F., Nishi, S. K., García-Regata, Ó., Araluce, R. Perez, Asensio, E. M., Castañer, O., Garcia-Rios, A., Oncina-Cánovas, A., Bouzas, C., Zulet, M. A., Rayó, E., Casas, R., Martin-Pelaez, S., Tojal-Sierra, L., Bernal-López, M. R., Carlos, S., Sorlí, J. V., Goday, A., Peña-Orihuela, P. J., Pastor-Morel, A., Eguaras, S., Zomeño, M. D., Delgado-Rodríguez, M., Babio, N., Fitó, M., and Salas-Salvadó, Jordi
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- 2023
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3. Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis
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Álvarez-Álvarez, L., Vitelli-Storelli, F., Rubín-García, M., García, S., Bouzas, C., Ruíz-Canela, M., Corella, D., Salas-Salvadó, J., Fitó, M., Martínez, J.A., Tojal-Sierra, L., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F.J., Santos-Lozano, J.M., Serra-Majem, L., Bueno-Cavanillas, A., García-Fernández, C., Esteve-Luque, V., Delgado-Rodríguez, M., Torrego-Ellacuría, M., Vidal, J., Prieto, L., Daimiel, L., Casas, R., García Arellano, A., Shyam, S., González, J.I., Castañer, O., García-Rios, A., Ortiz Díaz, F., Fernández, A.C., Sánchez-Villegas, A., Morey, M., Cano-Ibañez, N., Sorto-Sánchez, C., Bernal-López, M.R., Bes-Rastrollo, M., Nishi, S.K., Coltell, O., Zomeño, M.D., Peña-Orihuela, P.J., Aparicio, D.V., Zulet, M.A., Vázquez, Z., Babio, N., Pérez, K.A., Tur, J.A., and Martín-Sánchez, V.
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- 2024
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4. Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A
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Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargemen
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- 2024
5. Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis
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Universitat Rovira i Virgili, Álvarez-Álvarez L; Vitelli-Storelli F; Rubín-García M; García S; Bouzas C; Ruíz-Canela M; Corella D; Salas-Salvadó J; Fitó M; Martínez JA; Tojal-Sierra L; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Santos-Lozano JM; Serra-Majem L; Bueno-Cavanillas A; García-Fernández C; Esteve-Luque V; Delgado-Rodríguez M; Torrego-Ellacuría M; Vidal J; Prieto L; Daimiel L; Casas R; García Arellano A; Shyam S; González JI; Castañer O; García-Rios A; Ortiz Díaz F; Fernández AC; Sánchez-Villegas A; Morey M; Cano-Ibañez N; Sorto-Sánchez C; Bernal-López MR; Bes-Rastrollo M; Nishi SK; Coltell O; Zomeño MD; Peña-Orihuela PJ; Aparicio DV; Zulet MA; Vázquez Z; Babio N; Pérez KA; Tur JA; Martín-Sánchez V, Universitat Rovira i Virgili, and Álvarez-Álvarez L; Vitelli-Storelli F; Rubín-García M; García S; Bouzas C; Ruíz-Canela M; Corella D; Salas-Salvadó J; Fitó M; Martínez JA; Tojal-Sierra L; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Santos-Lozano JM; Serra-Majem L; Bueno-Cavanillas A; García-Fernández C; Esteve-Luque V; Delgado-Rodríguez M; Torrego-Ellacuría M; Vidal J; Prieto L; Daimiel L; Casas R; García Arellano A; Shyam S; González JI; Castañer O; García-Rios A; Ortiz Díaz F; Fernández AC; Sánchez-Villegas A; Morey M; Cano-Ibañez N; Sorto-Sánchez C; Bernal-López MR; Bes-Rastrollo M; Nishi SK; Coltell O; Zomeño MD; Peña-Orihuela PJ; Aparicio DV; Zulet MA; Vázquez Z; Babio N; Pérez KA; Tur JA; Martín-Sánchez V
- Abstract
This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD).Baseline and 1-year follow-up data from 5800 participants in the PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative food frequency questionnaires, and the adherence to MD using the Dietary Score. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The association between MD adherence and its environmental impact was calculated using adjusted multivariate linear regression models.After one year of intervention, the kcal/day consumed was significantly reduced (-125,1 kcal/day), adherence to a MD pattern was improved (+0,9) and the environmental impact due to the diet was significantly reduced (GHG: -361 g/CO2-eq; Acidification:-11,5 g SO2-eq; Eutrophication:-4,7 g PO4-eq; Energy use:-842,7 kJ; and Land use:-2,2 m2). Higher adherence to MD (high vs. low) was significantly associated with lower environmental impact both at baseline and one year follow-up. Meat products had the greatest environmental impact in all the factors analysed, both at baseline and at one-year follow-up, in spite of the reduction observed in their consumption.A program promoting a MD, after one year of intervention, significantly reduced the environmental impact in all the factors analysed. Meat products had the greatest environmental impact in all the dimensions analysed.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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- 2024
6. Effect of an Intensive Lifestyle Intervention on Circulating Biomarkers of Atrial Fibrillation-Related Pathways among Adults with Metabolic Syndrome: Results from a Randomized Trial
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Li L; Alonso A; Romaguera D; Alonso-Gómez AM; Razquin C; Tojal-Sierra L; Fiol M; Martínez-González MA; Subramanya V; Salas-Salvadó J; Fito M; Toledo E, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and Li L; Alonso A; Romaguera D; Alonso-Gómez AM; Razquin C; Tojal-Sierra L; Fiol M; Martínez-González MA; Subramanya V; Salas-Salvadó J; Fito M; Toledo E
- Abstract
Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55-75 years) with metabolic syndrome and body mass index between 27-40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants' mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were -0.01 (PICP), 0.20 (hsTnT), -0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (-14%, 95% confidence interval (CI) -26%, 0%) or smaller increases in 3-NT (-16%, 95% CI -25%, -5%) and NT-proBNP (-12%, 95% CI -23%, 1%). The intervention had minimal impact on hsTnT (-3%, 95% CI -7%, 2%) or PICP concentrations (-2%, 95% CI -9%, 6%). The eff
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- 2024
7. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health
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Universitat Rovira i Virgili, Doímnguez-Lpóez, I; Galkina, P; Parilli-Moser, I; Arancibia-Riveros, C; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Malcampo, M; Martínez, JA; Tojal-Sierra, L; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Santos-Lozano, JM; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Rubín-García, M; Pintó, X; Fernández-Aranda, F; Delgado-Rodríguez, M; Barabash-Bustelo, A; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Toledo, E; Atzeni, A; Asensio, EM; Vera, N; Garcia-Rios, A; Torres-Collado, L; Pérez-Farinós, N; Zulet, M; Chaplin, A; Casas, R; Martín-Peláez, S; Vaquero-Luna, J; Gómez-Pérez, AM; Vázquez-Ruiz, Z; Shyam, S; Ortega-Azorín, C; Talens, N; Peña-Orihuela, PJ; Oncina-Canovas, A; Diez-Espino, J; Babio, N; Fitó, M; Lamuela-Raventós, RM, Universitat Rovira i Virgili, and Doímnguez-Lpóez, I; Galkina, P; Parilli-Moser, I; Arancibia-Riveros, C; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Malcampo, M; Martínez, JA; Tojal-Sierra, L; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Santos-Lozano, JM; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Rubín-García, M; Pintó, X; Fernández-Aranda, F; Delgado-Rodríguez, M; Barabash-Bustelo, A; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Toledo, E; Atzeni, A; Asensio, EM; Vera, N; Garcia-Rios, A; Torres-Collado, L; Pérez-Farinós, N; Zulet, M; Chaplin, A; Casas, R; Martín-Peláez, S; Vaquero-Luna, J; Gómez-Pérez, AM; Vázquez-Ruiz, Z; Shyam, S; Ortega-Azorín, C; Talens, N; Peña-Orihuela, PJ; Oncina-Canovas, A; Diez-Espino, J; Babio, N; Fitó, M; Lamuela-Raventós, RM
- Abstract
Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk.A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM. Mediterranean diet (MedDiet) adherence is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests. Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests. Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in an older population.© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
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- 2024
8. Health-related quality of life in individuals with metabolic syndrome: A cross-sectional study
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Marcos-Delgado, A., López-García, E., Martínez-González, M.A., Salas-Salvadó, J., Corella, D., Fitó, M., Romaguera, D., Vioque, J., Alonso-Gómez, A.M., Wärnberg, J., Martínez, J.A., Serra-Majem, L., Estruch, R., Fernández-García, J.C., Lapetra, J., Pintó, X., Tur, J.A., López-Miranda, J., Cano-Ibañez, N., Delgado-Rodríguez, M., Matía-Martín, P., Daimiel, L., Carriedo, E., Vidal, J., Vázquez, C., Ros, E., Lozano-Oloriz, E., Bulló, M., Sorlí, J.V., Zomeño, M.D., Fiol, M., González-Palacios, S., Sorto-Sánchez, C., Pérez-Farinós, N., Goñi-Ruiz, N., Sanchez-Villegas, A., Muñoz-Garach, A., Santos-Lozano, J.M., Galera, A., Bouzas, C., Toledo, E., Babio, N., González, J.I., del Val-García, J.L., Moñino, M., Martínez-Vergaran, M.C., Goicolea-Güemez, L., Galilea-Zabalza, I., Basora, J., Muñoz, M.A., Builf, P., and Fernández-Villa, T.
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- 2020
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9. A systematic review and meta-analysis of the 2007 WCRF/AICR score in relation to cancer-related health outcomes
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Solans, M., Chan, D.S.M., Mitrou, P., Norat, T., and Romaguera, D.
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- 2020
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10. Psychometric properties of the Weight Locus of Control Scale (MWLCS): study with Spanish individuals of different anthropometric nutritional status
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Cebolla, A., Botella, C., Galiana, L., Fernández-Aranda, F., Toledo, E., Corella, D., Salas-Salvadó, Jordi, Fitó, M., Romaguera, D., Wärnberg, J., Serra-Majem, L. L., Pintó, X., Buil-Cosiales, P., Sorlí, J. V., Díaz-López, A., De la Torre, R., de Mott, M. Fernández, Díaz González, B. V., Corbella, E., Yañez, A., and Baños, R.
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- 2020
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11. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study
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Serra-Mir, M., Pérez-Heras, A., Viñas, C., Casas, R., Medina-Renom, A., Baena, J.M., García, M., Oller, M., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Martín, M.T., Sánchez, M.S., Altirriba, J., Manzano, E., Altés, A., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Doménech, M., Bulló, M., Babio, N., Basora, J., González, R., Molina, C., Márquez, F., Martínez, P., Ibarrola, N., Sorlí, M., García Roselló, J., Castro, A., Martin, F., Tort, N., Isach, A., Guasch-Ferre, M., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Frigola, J., Costa-Vizcaino, J., Salas-Huetos, A., Boj, J., Montañes, D., Papandreou, Christopher, Fernández-Ballart, J., Carrasco, P., Ortega-Azorín, C., Asensio, E.M., Osma, R., Barragán, R., Francés, F., Guillén, M., González, J.I., Sáiz, C., Portolés, O., Giménez, F.J., Coltell, O., Fernández-Carrión, R., Guillem-Sáiz, P., González-Monje, I., Quiles, L., Pascual, V., Riera, C., Pages, M.A., Godoy, D., Carratalá-Calvo, A., Sánchez-Navarro, S., Valero-Barceló, C., Tello, S., Vila, J., de la Torre, R., Muñoz-Aguayo, D., Elosua, R., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Rovira, A., Castañer, O., Farré, M., Toledo, E., Ruiz-Canela, M., Sanjulián, B., Sánchez-Tainta, A., Eguaras, S., Martí, A., Buil-Cosiales, P., SerranoMartínez, M., Diez-Espino, J., García-Arellano, A., Martínez-Lapiscina, E.H., Goñi, E., Vázquez, Z., Berrade, N., Extremera-Urabayen, V., Arroyo-Azpa, C., García-Pérez, L., Villanueva-Telleria, J., Cortés-Ugalde, F., Sagredo-Arce, T., Vigata-López, M.D., Arceiz Campo, M.T., Urtasun-Samper, A., Gueto Rubio, M.V., Churio-Beraza, B., Arós, F., Salaverria, I., del Hierro, T., Algorta, J., Francisco, S., Alonso-Gómez, A., Sanz, E., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, E., Wärnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Martínez-González, J., Velasco García, V., de Diego Salas, J., Baca Osorio, A., Gil Zarzosa, J., Sánchez Luque, J.J., Vargas López, E., Ruiz-Gutiérrez, V., Sánchez Perona, J., Montero Romero, E., García-García, M., Jurado-Ruiz, E., Fiol, M., Romaguera, D., García-Valdueza, M., Moñino, M., Munuera, S., Vivó, M., Bestard, F., Munar, J.A., Coll, L., Proenza, A., Prieto, R., Frontera, G., Fiol, F., Ginard, M., Jover, A., García, J., Santos-Lozano, J.M., Ortega-Calvo, M., Mellado, L., García-Corte, F.J., Román, P., Iglesias, P., Corchado, Y., Miró-Moriano, L., Domínguez-Espinaco, C., Lozano-Rodriguez, J.M., Vaquero-Diaz, S., López- Sabater, M.C., Castellote-Bargalló, A.I., Quifer-Rada, P., Tresserra-Rimbau, A., Álvarez-Pérez, J., Díaz-Benítez, E.M., Sánchez-Villegas, A., Casañas-Quintana, L.T., Pérez-Cabrera, J., Ruano-Rodríguez, C., Bautista-Castaño, I., Sarmiento de la Fe, F., García Pastor, J.A., Díaz-González, B.V., Castillo Anzalas, J.M., Sosa-Also, R.E., Medina-Ponce, J., de la Cruz, E., Fanlo-Maresma, M., Galera, A., Trias, F., Sarasa, I., Corbella, E., Corbella, X., Cabezas, C., Vinyoles, E., Rovira, M.A., García, L., Flores, G., Verdú, J.M., Baby, P., Ramos, A., Mengual, L., Roura, P., Yuste, M.C., Guarner, A., Santamaría, M.I., Mata, M., de Juan, C., Brau, A., Tur, J.A., Portillo, M.P., Sáez, G., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Forga, L., Gállego, J., García-Layana, A., Larrauri, A., Portu-Zapirain, J., Timiraus-Fernández, J., Becerra-Tomás, Nerea, Díaz-López, Andrés, Rosique-Esteban, Núria, Ros, Emilio, Buil-Cosiales, Pilar, Corella, Dolores, Estruch, Ramon, Fitó, Montserrat, Serra-Majem, Lluís, Arós, Fernando, Lamuela-Raventós, Rosa Maria, Fiol, Miquel, Santos-Lozano, José Manuel, Díez-Espino, Javier, Portoles, Olga, and Salas-Salvadó, Jordi
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- 2018
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12. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
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Universitat Rovira i Virgili, Shyam, S; Garcia-Gavilan, JF; Paz-Graniel, I; Gaforio, JJ; Martinez-Gonzalez, MA; Corella, D; Martinez, JA; Alonso-Gomez, AM; Waernberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Matia-Martin, P; Vidal, J; Vazquez, C; Daimiel, L; Ros, E; Fernandez-Aranda, F; Nishi, SK; Garcia-Regata, O; Toledo, E; Asensio, EM; Castaner, O; Garcia-Rios, A; Torres-Collado, L; Gomez-Gracia, E; Zulet, MA; Ruiz, NG; Casas, R; Cano-Ibanez, N; Tojal-Sierra, L; Gomez-Perez, AM; Sorli, JV; Cinza-Sanjurjo, S; Martin-Pelaez, S; Pena-Orihuela, PJ; Oncina-Canovas, A; Perez-Araluce, R; Zomeno, MD; Chaplin, A; Delgado-Rodriguez, M; Babio, N; Fito, M; Salas-Salvado, J, Universitat Rovira i Virgili, and Shyam, S; Garcia-Gavilan, JF; Paz-Graniel, I; Gaforio, JJ; Martinez-Gonzalez, MA; Corella, D; Martinez, JA; Alonso-Gomez, AM; Waernberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Matia-Martin, P; Vidal, J; Vazquez, C; Daimiel, L; Ros, E; Fernandez-Aranda, F; Nishi, SK; Garcia-Regata, O; Toledo, E; Asensio, EM; Castaner, O; Garcia-Rios, A; Torres-Collado, L; Gomez-Gracia, E; Zulet, MA; Ruiz, NG; Casas, R; Cano-Ibanez, N; Tojal-Sierra, L; Gomez-Perez, AM; Sorli, JV; Cinza-Sanjurjo, S; Martin-Pelaez, S; Pena-Orihuela, PJ; Oncina-Canovas, A; Perez-Araluce, R; Zomeno, MD; Chaplin, A; Delgado-Rodriguez, M; Babio, N; Fito, M; Salas-Salvado, J
- Abstract
Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.
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- 2023
13. Metabolic syndrome criteria and severity and carbon dioxide (CO2) emissions in an adult population
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Universitat Rovira i Virgili, Garcia, S; Pastor, R; Monserrat-Mesquida, M; Alvarez-Alvarez, L; Rubín-García, M; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Goday, A; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Pintó, X; Gaforio, JJ; Matia, P; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Sayón-Orea, C; Guillem-Saiz, P; Valle-Hita, C; Cabanes, R; Abete, I; Goicolea-Güemez, L; Gómez-Gracia, E; Tercero-Maciá, C; Colom, A; García-Ríos, A; Castro-Barquero, S; Fernández-García, JC; Santos-Lozano, JM; Cenoz, JC; Barragán, R; Khoury, N; Castañer, O; Zulet, MA; Vaquero-Luna, J; Bes-Rastrollo, M; de las Heras-delgado, S; Ciurana, R; Martin-Sánchez, V; Tur, JA; Bouzas, C, Universitat Rovira i Virgili, and Garcia, S; Pastor, R; Monserrat-Mesquida, M; Alvarez-Alvarez, L; Rubín-García, M; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Goday, A; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Pintó, X; Gaforio, JJ; Matia, P; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Sayón-Orea, C; Guillem-Saiz, P; Valle-Hita, C; Cabanes, R; Abete, I; Goicolea-Güemez, L; Gómez-Gracia, E; Tercero-Maciá, C; Colom, A; García-Ríos, A; Castro-Barquero, S; Fernández-García, JC; Santos-Lozano, JM; Cenoz, JC; Barragán, R; Khoury, N; Castañer, O; Zulet, MA; Vaquero-Luna, J; Bes-Rastrollo, M; de las Heras-delgado, S; Ciurana, R; Martin-Sánchez, V; Tur, JA; Bouzas, C
- Abstract
Metabolic syndrome (MetS) has become a growing risk factor of some non-communicable diseases. Increase of greenhouse gas emissions affects the planet.To assess the association between MetS severity and amount of carbon dioxide (CO2) emitted in an adult population.Cross-sectional study (n = 6646; 55-76-year-old-men; 60-75-year-old-women with MetS).Dietary habits were assessed using a pre-validated semi quantitative 143-item food frequency questionnaire. The amount of CO2 emitted due to the production of food consumed by person and day was calculated using a European database, and the severity of the MetS was calculated with the MetS Severity Score.Higher glycaemia levels were found in people with higher CO2 emissions. The risk of having high severe MetS was related to high CO2 emissions.Low CO2 emissions diet would help to reduce MetS severity. Advantages for both health and the environment were found following a more sustainable diet.ISRCTN, ISRCTN89898870 . Registered 05 September 2013.© 2023. The Author(s).
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- 2023
14. Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites
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Universitat Rovira i Virgili, Bullón-Vela V; Xu Y; Razquin C; Abete I; Zulet MA; Martínez-González MA; Buil-Corsiales P; Vitelli-Storelli F; Martín Sánchez V; Vazquez-Ruíz Z; Sayón-Orea C; Domínguez-Fernández M; Cid C; Estruch R; Lamuela-Raventós RM; Fitó M; Blanchart G; Babio N; Salas-Salvadó J; Tinahones FJ; Tur JA; Romaguera D; Konieczna J; Pintó X; Daimiel L; Rodriguez-Mateos A; Martínez JA, Universitat Rovira i Virgili, and Bullón-Vela V; Xu Y; Razquin C; Abete I; Zulet MA; Martínez-González MA; Buil-Corsiales P; Vitelli-Storelli F; Martín Sánchez V; Vazquez-Ruíz Z; Sayón-Orea C; Domínguez-Fernández M; Cid C; Estruch R; Lamuela-Raventós RM; Fitó M; Blanchart G; Babio N; Salas-Salvadó J; Tinahones FJ; Tur JA; Romaguera D; Konieczna J; Pintó X; Daimiel L; Rodriguez-Mateos A; Martínez JA
- Abstract
Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanon
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- 2023
15. Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity
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Universitat Rovira i Virgili, Paz-Graniel, I; Fitó, M; Ros, E; Buil-Cosiales, P; Corella, D; Babio, N; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Martín-Sánchez, V; Pintó, X; Gaforio, JJ; Matía-Martín, P; Vidal, J; Vázquez, C; Daimiel, L; García-Gavilán, JF; Toledo, E; Nishi, SK; Sorli, JV; Castañer, O; García-Ríos, A; de la Hera, MG; Barón-López, FJ; Ruiz-Canela, M; Morey, M; Casas, R; Garrido-Garrido, EM; Tojal-Sierra, L; Fernández-García, JC; Vázquez-Ruiz, Z; Fernández-Carrión, R; Goday, A; Peña-Orihuela, PJ; Compañ-Gabucio, L; Schröder, H; Martínez-Gonzalez, MA; Salas-Salvadó, J, Universitat Rovira i Virgili, and Paz-Graniel, I; Fitó, M; Ros, E; Buil-Cosiales, P; Corella, D; Babio, N; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Martín-Sánchez, V; Pintó, X; Gaforio, JJ; Matía-Martín, P; Vidal, J; Vázquez, C; Daimiel, L; García-Gavilán, JF; Toledo, E; Nishi, SK; Sorli, JV; Castañer, O; García-Ríos, A; de la Hera, MG; Barón-López, FJ; Ruiz-Canela, M; Morey, M; Casas, R; Garrido-Garrido, EM; Tojal-Sierra, L; Fernández-García, JC; Vázquez-Ruiz, Z; Fernández-Carrión, R; Goday, A; Peña-Orihuela, PJ; Compañ-Gabucio, L; Schröder, H; Martínez-Gonzalez, MA; Salas-Salvadó, J
- Abstract
Background: The COVID-19 pandemic has affected the implementation of most ongoing clinical trials worldwide including the PREDIMED-Plus study. The PREDIMED-Plus is an ongoing, multicenter, controlled intervention trial, aimed at weight-loss and cardiovascular disease prevention, in which participants were randomized (1:1 ratio) to an intervention group (energy-reduced Mediterranean diet, promotion of physical activity, and behavioral support) or to a control group (Mediterranean diet with usual care advice). When the pandemic began, the trial was in the midst of the planned intervention. The objective of this report was to examine the effects of the pandemic on the delivery of the intervention and to describe the strategies established to mitigate the possible adverse effects of the pandemic lockdown on data collection and adiposity. Methods: We assessed the integrity of the PREDIMED-Plus trial during 5 identified periods of the COVID-19 pandemic determined according to restrictions dictated by the Spanish government authorities. A standardized questionnaire was delivered to each of the 23 PREDIMED-Plus recruiting centers to collected data regarding the trial integrity. The effect of the restrictions on intervention components (diet, physical activity) was evaluated with data obtained in the three identified lockdown phases: pre lockdown, lockdown proper, and post lockdown. Results: During the lockdown (March/2020-June/2021), 4,612 participants (48% women, mean age 65y) attended pre-specified yearly follow-up visits to receive lifestyle recommendations and obtain adiposity measures. The overall mean (SD) of the proportions reported by each center showed that 40.4% (25.4) participants had in-person visits, 39.8% (18.2) participants were contacted by telephone and 35% (26
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- 2023
16. Carbon dioxide (CO2) emissions and adherence to Mediterranean diet in an adult population: the Mediterranean diet index as a pollution level index
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Universitat Rovira i Virgili, García, S; Bouzas, C; Mateos, D; Pastor, R; Alvarez, L; Rubín, M; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Goday, A; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Pintó, X; Gaforio, JJ; Matía, P; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Bes-Rastrollo, M; Guillem-Saiz, P; Nishi, S; Cabanes, R; Abete, I; Goicolea-Güemez, L; Gómez-Gracia, E; Signes-Pastor, AJ; Colom, A; García-Ríos, A; Castro-Barquero, S; Fernández-García, JC; Santos-Lozano, JM; Vázquez, Z; Sorli, JV; Pascual, M; Castañer, O; Zulet, MA; Vaquero-Luna, J; Basterra-Gortari, FJ; Babio, N; Ciurana, R; Martín-Sánchez, V; Tur, JA, Universitat Rovira i Virgili, and García, S; Bouzas, C; Mateos, D; Pastor, R; Alvarez, L; Rubín, M; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Goday, A; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Pintó, X; Gaforio, JJ; Matía, P; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Bes-Rastrollo, M; Guillem-Saiz, P; Nishi, S; Cabanes, R; Abete, I; Goicolea-Güemez, L; Gómez-Gracia, E; Signes-Pastor, AJ; Colom, A; García-Ríos, A; Castro-Barquero, S; Fernández-García, JC; Santos-Lozano, JM; Vázquez, Z; Sorli, JV; Pascual, M; Castañer, O; Zulet, MA; Vaquero-Luna, J; Basterra-Gortari, FJ; Babio, N; Ciurana, R; Martín-Sánchez, V; Tur, JA
- Abstract
Research related to sustainable diets is is highly relevant to provide better understanding of the impact of dietary intake on the health and the environment.To assess the association between the adherence to an energy-restricted Mediterranean diet and the amount of CO2 emitted in an older adult population.Using a cross-sectional design, the association between the adherence to an energy-reduced Mediterranean Diet (erMedDiet) score and dietary CO2 emissions in 6646 participants was assessed.Food intake and adherence to the erMedDiet was assessed using validated food frequency questionnaire and 17-item Mediterranean questionnaire. Sociodemographic characteristics were documented. Environmental impact was calculated through greenhouse gas emissions estimations, specifically CO2 emissions of each participant diet per day, using a European database. Participants were distributed in quartiles according to their estimated CO2 emissions expressed in kg/day: Q1 (≤2.01 kg CO2), Q2 (2.02-2.34 kg CO2), Q3 (2.35-2.79 kg CO2) and Q4 (≥2.80 kg CO2).More men than women induced higher dietary levels of CO2 emissions. Participants reporting higher consumption of vegetables, fruits, legumes, nuts, whole cereals, preferring white meat, and having less consumption of red meat were mostly emitting less kg of CO2 through diet. Participants with higher adherence to the Mediterranean Diet showed lower odds for dietary CO2 emissions: Q2 (OR 0.87; 95%CI: 0.76-1.00), Q3 (OR 0.69; 95%CI: 0.69-0.79) and Q4 (OR 0.48; 95%CI: 0.42-0.55) vs Q1 (reference).The Mediterranean diet can be environmentally protective since the higher the adherence to the Mediterranean diet, the lower total dietary CO2 emissions. Mediterranean Diet index may be used as a pollution level index.© 2023. The Author(s).
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- 2023
17. Red blood cell omega-3 fatty acids and attention scores in healthy adolescents
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Universitat Rovira i Virgili, Pinar-Martí A; Fernández-Barrés S; Gignac F; Persavento C; Delgado A; Romaguera D; Lázaro I; Ros E; López-Vicente M; Salas-Salvadó J; Sala-Vila A; Júlvez J, Universitat Rovira i Virgili, and Pinar-Martí A; Fernández-Barrés S; Gignac F; Persavento C; Delgado A; Romaguera D; Lázaro I; Ros E; López-Vicente M; Salas-Salvadó J; Sala-Vila A; Júlvez J
- Abstract
Omega-3 fatty acids are critical for brain function. Adolescence is increasingly believed to entail brain vulnerability to dietary intake. In contrast to the abundant research on the omega-3 docosahexaenoic acid (DHA) in cognition, research on DHA and attention in healthy adolescents is scarce. In addition, the role of alpha-linolenic acid (ALA), the vegetable omega-3 fatty acid, is unexplored. We examined associations between DHA and ALA and attention function among a healthy young population. In this cross-sectional study conducted in 372 adolescents (13.8 ± 0.9 years-old), we determined the red blood cell proportions of DHA and ALA by gas chromatography (objective biomarkers of their long-term dietary intake) and measured attention scores through the Attention Network Test. We constructed multivariable linear regression models to analyze associations, controlling for known confounders. Compared to participants at the lowest DHA tertile (reference), those at the highest DHA tertile showed significantly lower hit reaction time-standard error (higher attentiveness) (28.13 ms, 95% confidence interval [CI] = – 52.30; – 3.97), lower hit reaction time (– 38.30 ms, 95% CI = – 73.28; – 3.33) and lower executive conflict response (– 5.77 ms, 95% CI = – 11.44; – 0.09). In contrast, higher values were observed in those at the top tertile of ALA in hit reaction time compared to the lowest one (46.14 ms, 95% CI = 9.90; 82.34). However, a beneficial association was observed for ALA, with decreasing impulsivity index across tertiles. Overall, our results suggest that DHA (reflecting its dietary intake) is associated with attention performance in typically developing adolescents. The role of dietary ALA in attention is less clear, although higher blood levels of ALA appear to result
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- 2023
18. Effect of walnut consumption on neuropsychological development in healthy adolescents: a multi-school randomised controlled trial
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Universitat Rovira i Virgili, Pinar-Martí, A; Gignac, F; Fernández-Barrés, S; Romaguera, D; Sala-Vila, A; Lázaro, I; Ranzani, OT; Persavento, C; Delgado, A; Carol, A; Torrent, J; Gonzalez, J; Roso, E; Barrera-Gómez, J; López-Vicente, M; Boucher, O; Nieuwenhuijsen, M; Turner, MC; Burgaleta, M; Canals, J; Arija, V; Basagaña, X; Ros, E; Salas-Salvadó, J; Sunyer, J; Julvez, J, Universitat Rovira i Virgili, and Pinar-Martí, A; Gignac, F; Fernández-Barrés, S; Romaguera, D; Sala-Vila, A; Lázaro, I; Ranzani, OT; Persavento, C; Delgado, A; Carol, A; Torrent, J; Gonzalez, J; Roso, E; Barrera-Gómez, J; López-Vicente, M; Boucher, O; Nieuwenhuijsen, M; Turner, MC; Burgaleta, M; Canals, J; Arija, V; Basagaña, X; Ros, E; Salas-Salvadó, J; Sunyer, J; Julvez, J
- Abstract
Background: Omega-3 fatty acids are critical for neuropsychological functioning. Adolescence is increasingly believed to entail brain vulnerability to dietary intake. The potential benefit on adolescent neurodevelopment of consuming walnuts, a source of omega-3 alpha-linolenic acid (ALA), remains unclear. Methods: We conducted a 6-month multi-school-based randomised controlled nutrition intervention trial to assess whether walnut consumption has beneficial effects on the neuropsychological and behavioural development of adolescents. The study took place between 04/01/2016 and 06/30/2017 in twelve different high schools in Barcelona, Spain (ClinicalTrials.gov Identifier: NCT02590848). A total of 771 healthy teenagers aged 11–16 years were randomised into two equal groups (intervention or control). The intervention group received 30 g/day of raw walnut kernels to be incorporated into their diet for 6 months. Multiple primary endpoints concerning neuropsychological (working memory, attention, fluid intelligence, and executive function) and behavioural (socio-emotional and attention deficit hyperactivity disorder [ADHD] symptoms) development were assessed at baseline and after intervention. Red blood cell (RBC) ALA status was determined at baseline and 6 months as a measure of compliance. Main analyses were based on intention-to-treat using a linear mixed-effects model. A per-protocol effect of the intervention was analysed using inverse-probability weighting to account for post-randomisation prognostic factors (including adherence) using generalised estimating equations. Findings: In intention-to-treat analyses, at 6 months there were no statistically significant changes between the intervention and control groups for all primary endpoints. RBC ALA (%) significantly increa
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- 2023
19. An Energy-Reduced Mediterranean Diet, Physical Activity, and Body Composition: An Interim Subgroup Analysis of the PREDIMED-Plus Randomized Clinical Trial
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Universitat Rovira i Virgili, Konieczna, J; Ruiz-Canela, M; Galmes-Panades, AM; Abete, I; Babio, N; Fiol, M; Martín-Sánchez, V; Estruch, R; Vidal, J; Buil-Cosiales, P; García-Gavilán, JF; Moñino, M; Marcos-Delgado, A; Casas, R; Olbeyra, R; Fitó, M; Hu, FB; Martínez-Gonzalez, MA; Martínez, JA; Romaguera, D; Salas-Salvadó, J, Universitat Rovira i Virgili, and Konieczna, J; Ruiz-Canela, M; Galmes-Panades, AM; Abete, I; Babio, N; Fiol, M; Martín-Sánchez, V; Estruch, R; Vidal, J; Buil-Cosiales, P; García-Gavilán, JF; Moñino, M; Marcos-Delgado, A; Casas, R; Olbeyra, R; Fitó, M; Hu, FB; Martínez-Gonzalez, MA; Martínez, JA; Romaguera, D; Salas-Salvadó, J
- Abstract
Importance: Strategies targeting body composition may help prevent chronic diseases in persons with excess weight, but randomized clinical trials evaluating lifestyle interventions have rarely reported effects on directly quantified body composition. Objective: To evaluate the effects of a lifestyle weight-loss intervention on changes in overall and regional body composition. Design, Setting, and Participants: The ongoing Prevención con Dieta Mediterránea-Plus (PREDIMED-Plus) randomized clinical trial is designed to test the effect of the intervention on cardiovascular disease prevention after 8 years of follow-up. The trial is being conducted in 23 Spanish research centers and includes men and women (age 55-75 years) with body mass index between 27 and 40 and metabolic syndrome. The trial reported herein is an interim subgroup analysis of the intermediate outcome body composition after 3-year follow-up, and data analysis was conducted from February 1 to November 30, 2022. Of 6874 total PREDIMED-Plus participants, a subsample of 1521 individuals, coming from centers with access to a dual energy x-ray absorptiometry device, underwent body composition measurements at 3 time points. Intervention: Participants were randomly allocated to a multifactorial intervention based on an energy-reduced Mediterranean diet (MedDiet) and increased physical activity (PA) or to a control group based on usual care, with advice to follow an ad libitum MedDiet, but no physical activity promotion. Main Outcomes and Measures: The outcomes (continuous) were 3-year changes in total fat and lean mass (expressed as percentages of body mass) and visceral fat (in grams), tested using multivariable linear mixed-effects models. Clinical relevance of changes in body components (dichotomous) was assesse
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- 2023
20. Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk
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Universitat Rovira i Virgili, Donat-Vargas, C; Mico, V; San-Cristobal, R; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Fitó, M; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Damas-Fuentes, M; Lapetra, J; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Cinza-Sanjurjo, S; Pintó, X; Delgado-Rodríguez, M; Matía-Martín, P; Vidal, J; Causso, C; Ros, E; Toledo, E; Manzanares, JM; Ortega-Azorín, C; Castañer, O; Peña-Orihuela, PJ; Zazo, JM; Muñoz Bravo, C; Martinez-Urbistondo, D; Chaplin, A; Casas, R; Cano Ibáñez, N; Tojal-Sierra, L; Gómez-Perez, AM; Pascual Roquet-Jalmar, E; Mestre, C; Barragán, R; Schröder, H; Garcia-Rios, A; Candela García, I; Ruiz-Canela, M; Babio, N; Malcampo, M; Daimiel, L; Martinez, A, Universitat Rovira i Virgili, and Donat-Vargas, C; Mico, V; San-Cristobal, R; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Fitó, M; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Damas-Fuentes, M; Lapetra, J; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Cinza-Sanjurjo, S; Pintó, X; Delgado-Rodríguez, M; Matía-Martín, P; Vidal, J; Causso, C; Ros, E; Toledo, E; Manzanares, JM; Ortega-Azorín, C; Castañer, O; Peña-Orihuela, PJ; Zazo, JM; Muñoz Bravo, C; Martinez-Urbistondo, D; Chaplin, A; Casas, R; Cano Ibáñez, N; Tojal-Sierra, L; Gómez-Perez, AM; Pascual Roquet-Jalmar, E; Mestre, C; Barragán, R; Schröder, H; Garcia-Rios, A; Candela García, I; Ruiz-Canela, M; Babio, N; Malcampo, M; Daimiel, L; Martinez, A
- Abstract
Anemia causes hypo-oxygenation in the brain, which could lead to cognitive disorders. We examined dietary iron intake as well as anemia markers (i.e., hemoglobin, hematocrit, mean corpuscular volume) and diabetes coexistence in relation to neuropsychological function and quality of life. In this study, 6117 community-dwelling adults aged 55-75 years (men) and 60-75 years (women) with overweight/obesity and metabolic syndrome were involved. We performed the Mini-Mental State Examination (MMSE), the Trail Making Test parts A and B (TMT-A/B), Semantic Verbal Fluency of animals (VFT-a), Phonological Verbal Fluency of letter P (VFT-p), Digit Span Test (DST), the Clock Drawing Test (CDT), and the Short Form-36 Health Survey (SF36-HRQL test). Dietary iron intake did not influence neuropsychological function or quality of life. However, anemia and lower levels of anemia markers were associated with worse scores in all neurophysiological and SF36-HRQL tests overall, but were especially clear in the MMSE, TMT-B (cognitive flexibility), and the physical component of the SF36-HRQL test. The relationships between anemia and diminished performance in the TMT-A/B and VFT tasks were notably pronounced and statistically significant solely among participants with diabetes. In brief, anemia and reduced levels of anemia markers were linked to inferior cognitive function, worse scores in different domains of executive function, as well as a poorer physical, but not mental, component of quality of life. It was also suggested that the coexistence of diabetes in anemic patients may exacerbate this negative impact on cognition. Nevertheless, dietary iron intake showed no correlation with any of the outcomes. To make conclusive recommendations for clinical practice, our findings need to be thoro
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- 2023
21. Association of monetary diet cost of foods and diet quality in Spanish older adults
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Universitat Rovira i Virgili, Bouzas, C; Pastor, R; Garcia, S; Monserrat-Mesquida, M; Martinez-Gonzalez, MA; Salas-Salvado, J; Corella, D; Schröder, H; Martinez, JA; Alonso-Gomez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Romero-Secin, A; Pinto, X; Gaforio, JJ; Matia, P; Vidal, J; Zapatero, M; Daimiel, L; Ros, E; Garcia-Arellano, A; Babio, N; Gonzalez-Monje, I; Castañer, O; Abete, I; Tojal-Sierra, L; Benavente-Marin, JC; Signes-Pastor, A; Konieczna, J; Garcia-Rios, A; Castro-Barquero, S; Fernandez-Garcia, JC; Santos-Lozano, JM; Bes-Rastrollo, M; Mestres, C; Guillem-Saiz, P; Goday, A; Goicolea-Güemez, L; Puig-Aguilo, E; Ruiz-Canela, M; Palau-Galindo, A; Fito, M; Tur, JA, Universitat Rovira i Virgili, and Bouzas, C; Pastor, R; Garcia, S; Monserrat-Mesquida, M; Martinez-Gonzalez, MA; Salas-Salvado, J; Corella, D; Schröder, H; Martinez, JA; Alonso-Gomez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Romero-Secin, A; Pinto, X; Gaforio, JJ; Matia, P; Vidal, J; Zapatero, M; Daimiel, L; Ros, E; Garcia-Arellano, A; Babio, N; Gonzalez-Monje, I; Castañer, O; Abete, I; Tojal-Sierra, L; Benavente-Marin, JC; Signes-Pastor, A; Konieczna, J; Garcia-Rios, A; Castro-Barquero, S; Fernandez-Garcia, JC; Santos-Lozano, JM; Bes-Rastrollo, M; Mestres, C; Guillem-Saiz, P; Goday, A; Goicolea-Güemez, L; Puig-Aguilo, E; Ruiz-Canela, M; Palau-Galindo, A; Fito, M; Tur, JA
- Abstract
Background: A major barrier to a healthy diet may be the higher price of healthy foods compared to low-quality foods. Objectives: This study aimed to assess the association between the monetary cost of food and diet quality in Spanish older adults at high risk of cardiovascular disease. Methods: Cross-sectional analysis was carried out in Spanish older adults (n = 6,838; 48.6% female). A validated food frequency questionnaire was used to assess dietary intake. Metabolic syndrome severity, adherence to the Mediterranean diet (MedDiet), adherence to a provegetarian dietary pattern, and dietary inflammatory index were assessed. The economic cost of the foods was obtained from the Spanish Ministry of Agriculture Fisheries and Food database (2015–2017, the period of time when the participants were recruited). The total cost of diet adjusted per 1,000 kcal was computed. Results: The healthier dietary pattern was associated with a higher cost of the diet. Higher adherence to the MedDiet, anti-inflammatory diet, and the healthy version of the provegetarian dietary pattern were related to higher costs of the diet. Conclusion: Higher diet quality was associated with a higher dietary cost of the diet per 1,000 kcal/day. Food prices can be an important component of interventions and policies aimed at improving people's diets and preventing diet-related chronic diseases. Clinical trial registry number: The trial was registered in 2014 at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870) with the number 89898870.
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- 2023
22. How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?
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Universitat Rovira i Virgili, Paz-Graniel, I; Babio, N; Nishi, SK; Martinez-Gonzalez, MA; Corella, D; Fito, M; Martinez, A; Alonso-Gomez, AM; Warnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Santos-Lozano, JM; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Delgado-Rodriguez, M; Matia-Martin, P; Vidal, J; Calderon-Sanchez, C; Daimiel, L; Ros, E; Fernandez-Aranda, F; Toledo, E; Valle-Hita, C; Sorli, JV; Lassale, C; Garcia-Rios, A; Oncina-Canovas, A; Baron-Lopez, FJ; Zulet, MA; Rayo, E; Casas, R; Thomas-Carazo, E; Tojal-Sierra, L; Damas-Fuentes, M; Ruiz-Canela, M; de las Heras-delgado, S; Fernandez-Carrion, R; Castaner, O; Pena-Orihuela, PJ; Gonzalez-Palacios, S; Buil-Cosiales, P; Goday, A; Salas-Salvado, J, Universitat Rovira i Virgili, and Paz-Graniel, I; Babio, N; Nishi, SK; Martinez-Gonzalez, MA; Corella, D; Fito, M; Martinez, A; Alonso-Gomez, AM; Warnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Santos-Lozano, JM; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Delgado-Rodriguez, M; Matia-Martin, P; Vidal, J; Calderon-Sanchez, C; Daimiel, L; Ros, E; Fernandez-Aranda, F; Toledo, E; Valle-Hita, C; Sorli, JV; Lassale, C; Garcia-Rios, A; Oncina-Canovas, A; Baron-Lopez, FJ; Zulet, MA; Rayo, E; Casas, R; Thomas-Carazo, E; Tojal-Sierra, L; Damas-Fuentes, M; Ruiz-Canela, M; de las Heras-delgado, S; Fernandez-Carrion, R; Castaner, O; Pena-Orihuela, PJ; Gonzalez-Palacios, S; Buil-Cosiales, P; Goday, A; Salas-Salvado, J
- Abstract
Background and Aims. To control the COVID-19 spread, in March 2020, a forced home lockdown was established in Spain. In the present study, we aimed to assess the effect of mobility and social COVID-19-established restrictions on depressive symptomatology in older adults with metabolic syndrome. We hypothesize that severe restrictions might have resulted in detrimental changes in depressive symptomatology. Methods. 2,312 PREDIMED-Plus study participants ( men = 53.9 %; mean age = 64.9 ± 4.8 years) who completed a COVID-19 lockdown questionnaire to assess the severity of restrictions/lockdown and the validated Spanish version of the Beck Depression Inventory-II (BDI-II) during the three established phases concerning the COVID-19 lockdown in Spain (prelockdown, lockdown, and postlockdown) were included in this longitudinal analysis. Participants were categorized according to high or low lockdown severity. Analyses of covariance were performed to assess changes in depressive symptomatology across lockdown phases. Results. No significant differences in participant depression symptomatology changes were observed between lockdown severity categories (low/high) at the studied phases. During the lockdown phase, participants showed a decrease in BDI-II score compared to the prelockdown phase (mean (95% CI), -0.48 (-0.24, -0.72), P < 0.001 ); a nonsignificantly larger decrease was observed in participants allocated in the low-lockdown category (low: -0.59 (-0.95, -0.23), high: -0.43 (-0.67, -0.19)). Similar decreases in depression symptomatology were found for the physical environment dimension. The post- and prelockdown phase BDI-II scores were roughly similar. Conclusions. The COVID-19 pandemic lockdown was associated with a decrease in depressive symptomatology that returned to
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- 2023
23. Lifestyles, Left Atrial Structure and Function, and Cognitive Decline in Adults with Metabolic Syndrome
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Universitat Rovira i Virgili, Casanova, IG; Alonso-Gómez, AM; Romaguera, D; Toledo, E; Li, LZ; Fortuny, E; López, L; Ramallal, R; Salas-Salvadó, J; Tojal-Sierra, L; Castañer, O; Alonso, A, Universitat Rovira i Virgili, and Casanova, IG; Alonso-Gómez, AM; Romaguera, D; Toledo, E; Li, LZ; Fortuny, E; López, L; Ramallal, R; Salas-Salvadó, J; Tojal-Sierra, L; Castañer, O; Alonso, A
- Abstract
Evidence supports associations of lifestyle (including diet and physical activity) and weight with cognitive functioning, but the pathways responsible for these associations have not been fully elucidated. Because healthier lifestyles have been associated with better left atrial structure and function, which in turn is associated with better cognitive functioning, we tested the hypothesis that left atrial structure and function is a potential mediator of the association between lifestyle and cognition. We included 476 participants classed as overweight or obese with metabolic syndrome from three centers in Spain. These participants underwent lifestyle assessments and transthoracic echocardiography at baseline and repeated measurements of the Trail Making A test, a measure of executive function, taken at baseline and at the two-year follow-up. We conducted mediation analyses to test if measures of left atrial structure and function mediated associations between adherence to the Mediterranean diet scores, physical activity, and weight at baseline, as well as a two-year change in Trail Making A scores. The analysis did not find an association between these factors and Trail Making A scores, and no indirect effects appeared to be mediated by echocardiographic measurements. The modest sample size in this analysis is a limitation, and larger studies should be conducted to determine potential cardiovascular factors mediating the association between lifestyle and cognition.
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- 2023
24. Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants
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Danaei, G, Fahimi, S, Lu, Y, Zhou, B, Hajifathalian, K, Di Cesare, M, Lo, WC, Reis-Santos, B, Cowan, MJ, Shaw, JE, Bentham, J, Lin, JK, Bixby, H, Magliano, D, Bovet, P, Miranda, JJ, Khang, YH, Stevens, GA, Riley, LM, Ali, MK, Ezzati, M, Abdeen, ZA, Kadir, KA, Abu-Rmeileh, M, Acosta-Cazares, B, Aekplakorn, W, Aguilar-Salinas, CA, Ahmadvand, A, Al Nsour, M, Alkerwi, A, Amouyel, P, Andersen, LB, Anderssen, SA, Andrade, DS, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, A, Batieha, AM, Baur, LA, Ben Romdhane, H, Bernabe-Ortiz, A, Bhargava, SK, Bi, Y, Bjerregaard, P, Björkelund, C, Blake, M, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Brajkovich, I, Breckenkamp, J, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, Cabrera de León, A, Can, G, Cândido, AP, Capuano, V, Carvalho, MJ, Casanueva, FF, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, CJ, Chen, F, Chen, S, Cheng, CY, Chetrit, A, Chiou, ST, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D'Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Egbagbe, EE, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-de la Peña, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Finn, JD, Föger, B, Foo, LH, Fouad, HM, Francis, DK, Franco Mdo, C, Frontera, G, Furusawa, T, Gaciong, Z, Galbarczyk, A, Garnett, SP, Gaspoz, JM, Gasull, M, Gates, L, Geleijnse, JM, Ghasemain, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Gonzalez Gross, M, González Rivas, JP, Gorbea, MB, Gottrand, F, Grant, JF, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hardy, R, Hari Kumar, R, Heidemann, C, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Horimoto, AR, Hormiga, CM, Horta, BL, Houti, L, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, MA, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Kiechl, S, Kim, J, Kiyohara, Y, Kolsteren, P, Korrovits, P, Koskinen, S, Kratzer, W, Kromhout, D, Kula, K, Kurjata, P, Kyobutungi, C, Lachat, C, Laid, Y, Lam, TH, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Muñoz, LM, Li, Y, Lim, WY, Lima-Costa, MF, Lin, HH, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Lundqvist, A, Lytsy, P, Ma, G, Machado-Coelho, GL, Machi, S, Maggi, S, Makdisse, M, Mallikharjuna v, K, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Matsha, TE, Mbanya, JC, McFarlane, SR, McGarvey, ST, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AM, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohan, V, Mohd Yusoff, MF, Møller, NC, Molnar, D, Mondo, CK, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Námešná, J, Nang, EE, Nangia, VB, Navarrete-Muñoz, EM, Ndiaye, NC, Nervi, F, Nguyen, ND, Nieto-Martínez, RE, Alvarado, L, Ning, G, Ninomiya, T, Noale, M, Noto, D, Ochoa-Avilés, M, Oh, K, Onat, A, Osmond, C, Otero, JA, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Pereira, AC, Peters, A, Peykari, N, Pilav, A, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, ML, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Raitakari, O, Ramachandra Rao, S, Ramachandran, A, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PF, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez, LA, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rojas-Martinez, R, Romaguera, D, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Santos, RN, Santos, R, Sardinha, LB, Scazufca, M, Schargrodsky, H, Scheidt-Nave, C, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, AM, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, MB, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Steene-Johannessen, J, Stehle, P, Stein, AD, Stessman, J, Stöckl, D, Stokwiszewski, J, Strufaldi, MW, Sun, CA, Sundström, J, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tarawneh, M, Tarqui-Mamani, CB, Thijs, L, Tolstrup, JS, Topbas, M, Torrent, M, Traissac, P, Trinh, OT, Tulloch-Reid, MK, Tuomainen, TP, Turley, ML, Tzourio, C, Ueda, P, Ukoli, FM, Ulmer, H, Valdivia, G, van Valkengoed, IG, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, M, Vioque, J, Virtanen, J, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Wade, AN, Wagner, A, Walton, J, Mohamud, WN, Wang, MD, Wang, YX, Wannamethee, SG, Weerasekera, D, Whincup, PH, Widhalm, K, Wiecek, A, Wilks, RJ, Willeit, J, Wojtyniak, B, Wong, TY, Woo, J, Woodward, M, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yang, X, Ye, X, Yoshihara, A, Younger-Coleman, NO, Zambon, S, Zargar, AH, Zdrojewski, T, Zhao, W, and Zheng, Y
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- 2015
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25. One-year longitudinal association between changes in dietary choline or betaine intake association with cardiometabolic variables in the PREDIMED-Plus trial
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Díez-Ricote L, San-Cristobal R, Concejo MJ, Martínez-González MÁ, Corella D, Salas-Salvadó J, Goday A, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Sánchez VM, Pintó X, Gaforio JJ, Matía-Martín P, Vidal J, Fontao SM, Ros E, Vázquez-Ruiz Z, Ortega-Azorín C, García-Gavilán JF, Malcampo M, Martínez-Urbistondo D, Tojal-Sierra L, Rodríguez AG, Gómez-Bellvert N, Chaplin A, García-Ríos A, Bernal-López RM, Santos-Lozano JM, Basterra-Gortari J, Sorlí JV, Murphy M, Gasulla G, Micó V, Salaverria-Lete I, Ochandorena EG, Babio N, Herraiz X, Ordovás JM, and Daimiel L
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cardiovascular risk ,choline ,Mediterranean diet ,renal variables ,betaine ,cardiometabolic parameters - Abstract
BACKGROUND: Choline and betaine intake have been related to cardiovascular health. OBJECTIVE: We aimed to explore the relationship between 1-year changes in dietary intake of choline or betaine and 1-year changes in cardiometabolic and renal function traits within the frame of the PREDIMED-Plus trial. DESIGN: We used baseline and 1 year follow-up data from 5,613 participants (48.2% female and 51.8% male, mean age 65.01 ± 4.91) to assess cardiometabolic traits, and 3,367 participants to assess renal function, of the Spanish PREDIMED-Plus ("PREvention with MEDiterranean DIet") trial. Participants met at least three criteria of metabolic syndrome (MetS) and had overweight or obesity (BMI =27 and =40kg/m2). These criteria were similar to those of the PREDIMED parent study. Dietary intake of choline and betaine was estimated from the Food Frequency Questionnaire (FFQ). RESULTS: The greatest one-year increase in dietary choline or betaine intake (Q4) was associated with improved serum glucose (-3.39 and -2.72 mg/dL for choline or betaine, respectively) and glycated hemoglobin levels (-0.10% for Q4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were: reduced body weight (-2.93 and -2.78 Kg, respectively), BMI (-1.05 and -0.99 Kg/m2, respectively), waist circumference (-3.37 and -3.26 cm, respectively), total cholesterol (-4.74 and -4.52 mg/dL, respectively) and LDL cholesterol (-4.30 and -4.16 mg/dL, respectively). Urine creatinine was reduced in Q4 of one-year increase in choline or betaine intake (-5.42 and -5.74 mg/dL, respectively). CONCLUSIONS: Increase in dietary choline or betaine intake were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they required further investigation.
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- 2022
26. Circadian nutritional behaviours and risk of cardiovascular disease in NutriNet-Santé
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Srour, B, primary, Palomar-Cros, A, additional, Andreeva, VA, additional, Fezeu, LK, additional, Julia, C, additional, Bellicha, A, additional, Kesse-Guyot, E, additional, Romaguera, D, additional, Kogevinas, M, additional, and Touvier, M, additional
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- 2022
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27. Circadian nutritional behaviours and risk of type 2 diabetes in NutriNet-Santé
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Srour, B, primary, Palomar-Cros, A, additional, Andreeva, VA, additional, Fezeu, LK, additional, Julia, C, additional, Bellicha, A, additional, Kesse-Guyot, E, additional, Romaguera, D, additional, Kogevinas, M, additional, and Touvier, M, additional
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- 2022
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28. Adherence to the mediterranean lifestyle and desired body weight loss in a mediterranean adult population with overweight: A predimed‐plus study
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Universitat Rovira i Virgili, Bouzas C., Bibiloni M.D.M., Julibert A., Ruiz?canela M., Salas?salvadó J., Corella D., Zomeño M.D., Romaguera D., Vioque J., Alonso?gómez Á.M., Wärnberg J., Alfredo Martínez J., Serra?majem L., Estruch R., Tinahones F.J., Lapetra J., Pintó X., Ríos A.G., Bueno?cavanillas A., Gaforio J.J., Matía?martín P., Daimiel L., Martín?sánchez V., Vidal J., Vázquez C., Ros E., Fernandez?lázaro C.I., Becerra?tomás N., Gimenez?alba I.M., Muñoz J., Morey M., Oncina?canovas A., Tojal?sierra L., Pérez?lópez J., Abete I., Casañas?quintana T., Castro?barquero S., Rosa Bernal?López M., Santos?lozano J.M., Galera A., Bouzas C., Bibiloni M.D.M., Julibert A., Ruiz?canela M., Salas?salvadó J., Corella D., Zomeño M.D., Romaguera D., Vioque J., Alonso?gómez Á.M., Wärnberg J., Alfredo Martínez J., Universitat Rovira i Virgili, and Bouzas C., Bibiloni M.D.M., Julibert A., Ruiz?canela M., Salas?salvadó J., Corella D., Zomeño M.D., Romaguera D., Vioque J., Alonso?gómez Á.M., Wärnberg J., Alfredo Martínez J., Serra?majem L., Estruch R., Tinahones F.J., Lapetra J., Pintó X., Ríos A.G., Bueno?cavanillas A., Gaforio J.J., Matía?martín P., Daimiel L., Martín?sánchez V., Vidal J., Vázquez C., Ros E., Fernandez?lázaro C.I., Becerra?tomás N., Gimenez?alba I.M., Muñoz J., Morey M., Oncina?canovas A., Tojal?sierra L., Pérez?lópez J., Abete I., Casañas?quintana T., Castro?barquero S., Rosa Bernal?López M., Santos?lozano J.M., Galera A., Bouzas C., Bibiloni M.D.M., Julibert A., Ruiz?canela M., Salas?salvadó J., Corella D., Zomeño M.D., Romaguera D., Vioque J., Alonso?gómez Á.M., Wärnberg J., Alfredo Martínez J.
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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross‐sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED‐Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut‐offs of this percentage (Q1: <10%, n = 1495; Q2: 10–15%, n = 1804; Q3: <15–20%, n = 1470; Q4: ≥20%, n = 1589). Diet was assessed using a validated food frequency questionnaire and a 17‐item Mediterranean diet questionnaire. Physical activity was assessed by the validated Minnesota‐REGICOR and the validated Spanish version of the Nurses’ Health Study questionnaire. Results. Participants reporting higher percentages of desired weight loss (Q3 and Q4) were younger, had higher real and perceived BMI and were more likely to have abdominal obesity. Desired weight loss correlated inversely to physical activity (Q1: 2106 MET min/week; Q4: 1585 MET min/week. p < 0.001) and adherence to Mediterranean diet (Q1: 8.7; Q4: 8.3. p < 0.001). Conclusions. In older Mediterranean individuals with weight excess, desired weight loss was inversely associated with Mediterranean lifestyle adherence. Deeply rooted aspects of the MedDiet remained similar across groups. Longitudinal research is advised to be able to establish causality.
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- 2020
29. Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study
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Universitat Rovira i Virgili, Gallardo-Alfaro L; Del Mar Bibiloni M; Mascaró CM; Montemayor S; Ruiz-Canela M; Salas-Salvadó J; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Fernández-García JC; Lapetra J; Pintó X; Ríos AG; Bueno-Cavanillas A; Gaforio JJ; Matía-Martín P; Daimiel L; Micó-Pérez RM; Vidal J; Vázquez C; Ros E; Fernandez-Lázaro CI; Becerra-Tom N; Gimenez-Alba IM; Zomeño MD; Konieczna J; Compañ-Gabucio L; Tojal-Sierra L; Pérez-López J; Zulet MÁ; Casañas-Quintana T; Castro-Barquero S; Gómez-Pérez AM; Santos-Lozano JM; Gallardo-Alfaro L; Del Mar Bibiloni M; Mascaró CM; Montemayor S; Ruiz-Canela M; Salas-Salvad J; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J, Universitat Rovira i Virgili, and Gallardo-Alfaro L; Del Mar Bibiloni M; Mascaró CM; Montemayor S; Ruiz-Canela M; Salas-Salvadó J; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Fernández-García JC; Lapetra J; Pintó X; Ríos AG; Bueno-Cavanillas A; Gaforio JJ; Matía-Martín P; Daimiel L; Micó-Pérez RM; Vidal J; Vázquez C; Ros E; Fernandez-Lázaro CI; Becerra-Tom N; Gimenez-Alba IM; Zomeño MD; Konieczna J; Compañ-Gabucio L; Tojal-Sierra L; Pérez-López J; Zulet MÁ; Casañas-Quintana T; Castro-Barquero S; Gómez-Pérez AM; Santos-Lozano JM; Gallardo-Alfaro L; Del Mar Bibiloni M; Mascaró CM; Montemayor S; Ruiz-Canela M; Salas-Salvad J; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J
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Healthy lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease the likelihood of developing metabolic syndrome (MetS). The aim of this study was to report main lifestyle components and related factors according to the MetS severity. Cross-sectional analysis was done of baseline lifestyle factors from 5739 participants with overweight/obesity and MetS features (aged 55-75 years) included in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. Participants were categorized in tertiles according to a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, dietary nutrient intake, biochemical marker levels, as well as a Dietary Inflammatory Index and depression symptoms (Beck Depression Inventory-II) were measured. Diet quality was assessed using a 17-item energy-restricted MD questionnaire. Duration and intensity of PA was self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire. Sedentary behaviours were measured using the Spanish version of the Nurses' Health Study questionnaire. The 30 s chair stand test was also assessed. Participants with highest MetSSS showed higher values of cardiovascular risk factors (except for total cholesterol and LDL cholesterol), depression risk, sedentary and TV viewing time, and lower moderate and vigorous leisure-time physical activity (LTPA). Highest MetSSS participants tended to a pro-inflammatory dietary pattern and tended to lower MD adherence. In addition, they showed lower carbohydrate and nut intake and higher intake of protein, saturated and trans fatty acids, cholesterol, iodine, sodium, red and processed meat products, other oils different from olive oil and spirit alcoholic drinks. The highest MetS severity score was associated wi
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- 2020
30. O5-5 Neighbourhood Walkability and Physical Activity: Moderating Role of a Physical Activity Interventions in Overweight and Obese Older Adults with Metabolic Syndrome
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Colom, A, Mavoa, S, Ruiz, M, Wärnberg, J, Muncunill, J, Konieczna, J, Barón-López, FJ, Vich, G, Fitó, M, Salas-Salvadó, J, Romaguera, D, Colom, A, Mavoa, S, Ruiz, M, Wärnberg, J, Muncunill, J, Konieczna, J, Barón-López, FJ, Vich, G, Fitó, M, Salas-Salvadó, J, and Romaguera, D
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Background While urban built environments might promote active ageing, an infrequently studied question is how the neighbourhood walkability modulates physical activity changes during a physical activity intervention program in older adults. We assessed the influence of objectively assessed neighbourhood walkability on the change in physical activity during the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial. PREDIMED-Plus is a parallel-group, randomized trial which tested the effect of an intensive lifestyle intervention on cardiovascular disease prevention, in overweight and obese participants with the metabolic syndrome. Method The present study involved 228 PREDIMED-Plus senior participants aged between 55 to 75, recruited in Palma de Mallorca (Spain). Overweight/obese older adults with metabolic syndrome were randomized to an intensive weight-loss lifestyle intervention or a control group (106 intervention group and 122 control group). A home neighborhood environment walkability index (residential density, land use mix, intersections density) was calculated using geographic information systems (1km sausage-network buffer). Physical activity was assessed using accelerometer for seven days, and a REGICOR validated physical activity questionnaire, at baseline and 2 follow-up visits (six-months and one-year later). Generalized Additive Mixed Models (GAMMs) were fitted to estimate the association between the neighbourhood walkability index and changes in physical activity during follow-up. Results Higher neighbourhood walkability (1 z-score increment) was associated with moderate-to-vigorous accelerometer assessed physical activity duration, (ß = 3,44; 95% CI = 0.52;6.36 minutes per day). When analyses were stratified by intervention arm, the association was only observed in the intervention group (ß = 6.357; 95% CI = 2.07;10.64 minutes per day) (p for interaction = 0.055). There were no statistically signifi
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- 2022
31. Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF)
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Universitat Rovira i Virgili, Martinez-Perez C; Daimiel L; Climent-Mainar C; Martínez-González MÁ; Salas-Salvadó J; Corella D; Schröder H; Martinez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Bueno-Cavanillas A; Tur JA; Sánchez VM; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Ros E; Basterra J; Babio N; Guillem-Saiz P; Zomeño MD; Abete I; Vaquero-Luna J; Barón-López FJ; Gonzalez-Palacios S; Konieczna J; Garcia-Rios A; Bernal-López MR; Santos-Lozano JM; Bes-Rastrollo M; Khoury N; Saiz C; Pérez-Vega KA; Zulet MA; Tojal-Sierra L; Ruiz ZV; Martinez MA; Malcampo M; Ordovás JM; San-Cristobal R, Universitat Rovira i Virgili, and Martinez-Perez C; Daimiel L; Climent-Mainar C; Martínez-González MÁ; Salas-Salvadó J; Corella D; Schröder H; Martinez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Bueno-Cavanillas A; Tur JA; Sánchez VM; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Ros E; Basterra J; Babio N; Guillem-Saiz P; Zomeño MD; Abete I; Vaquero-Luna J; Barón-López FJ; Gonzalez-Palacios S; Konieczna J; Garcia-Rios A; Bernal-López MR; Santos-Lozano JM; Bes-Rastrollo M; Khoury N; Saiz C; Pérez-Vega KA; Zulet MA; Tojal-Sierra L; Ruiz ZV; Martinez MA; Malcampo M; Ordovás JM; San-Cristobal R
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Recent lifestyle changes include increased consumption of highly processed foods (HPF), which has been associated with an increased risk of non-communicable diseases (NCDs). However, nutritional information relies on the estimation of HPF consumption from food-frequency questionnaires (FFQ) that are not explicitly developed for this purpose. We aimed to develop a short screening questionnaire of HPF consumption (sQ-HPF) that integrates criteria from the existing food classification systems.Data from 4400 participants (48.1% female and 51.9% male, 64.9 ± 4.9 years) of the Spanish PREDIMED-Plus ("PREvention with MEDiterranean DIet") trial were used for this analysis. Items from the FFQ were classified according to four main food processing-based classification systems (NOVA, IARC, IFIC and UNC). Participants were classified into tertiles of HPF consumption according to each system. Using binomial logistic regression, food groups associated with agreement in the highest tertile for at least two classification systems were chosen as items for the questionnaire. ROC analysis was used to determine cut-off points for the frequency of consumption of each item, from which a score was calculated. Internal consistency of the questionnaire was assessed through exploratory factor analysis (EFA) and Cronbach's analysis, and agreement with the four classifications was assessed with weighted kappa coefficients.Regression analysis identified 14 food groups (items) associated with high HPF consumption for at least two classification systems. EFA showed that items were representative contributors of a single underlying factor, the "HPF dietary pattern" (factor loadings around 0.2). We constructed a questionnaire asking about the frequency of consumption of those items. The threshold frequ
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- 2022
32. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
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Universitat Rovira i Virgili, Martín-Peláez S; Serra-Majem L; Cano-Ibáñez N; Martínez-González MÁ; Salas-Salvadó J; Corella D; Lassale C; Martínez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Fernández-Aranda F; Bueno-Cavanillas A; Tur JA; Martín V; Pintó X; Delgado-Rodríguez M; Matía P; Vidal J; Vázquez C; Daimiel L; Ros E; Toledo E; Nishi SK; Sorli JV; Malcampo M; Zulet MÁ; Moreno-Rodríguez A; Cueto-Galán R; Vivancos-Aparicio D; Colom A; García-Ríos A; Casas R; Bernal-López MR; Santos-Lozano JM; Vázquez Z; Gómez-Martínez C; Ortega-Azorín C; del Val JL; Abete I; Goikoetxea-Bahon A; Pascual E; Becerra-Tomás N; Chillarón JJ; Sánchez-Villegas A, Universitat Rovira i Virgili, and Martín-Peláez S; Serra-Majem L; Cano-Ibáñez N; Martínez-González MÁ; Salas-Salvadó J; Corella D; Lassale C; Martínez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Fernández-Aranda F; Bueno-Cavanillas A; Tur JA; Martín V; Pintó X; Delgado-Rodríguez M; Matía P; Vidal J; Vázquez C; Daimiel L; Ros E; Toledo E; Nishi SK; Sorli JV; Malcampo M; Zulet MÁ; Moreno-Rodríguez A; Cueto-Galán R; Vivancos-Aparicio D; Colom A; García-Ríos A; Casas R; Bernal-López MR; Santos-Lozano JM; Vázquez Z; Gómez-Martínez C; Ortega-Azorín C; del Val JL; Abete I; Goikoetxea-Bahon A; Pascual E; Becerra-Tomás N; Chillarón JJ; Sánchez-Villegas A
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Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55–75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240–279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may pla
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- 2022
33. Dairy Product Consumption and Changes in Cognitive Performance: Two-Year Analysis of the PREDIMED-Plus Cohort
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Universitat Rovira i Virgili, Ni, JQ; Nishi, SK; Babio, N; Martínez-González, MA; Corella, D; Castañer, O; Martínez, JA; Alonso-Gómez, AM; Gómez-Gracia, E; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Martín-Sánchez, V; Pintó, X; Gaforio, JJ; Bustelo, AB; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Toledo, E; Coltell, O; Gómez-Martínez, C; Zomeño, MD; Donat-Vargas, C; Goicolea-Güemez, L; Bouzas, C; Garcia-de-la-Hera, M; Chaplin, A; Garcia-Rios, A; Casas, R; Cornejo-Pareja, I; Santos-Lozano, JM; Rognoni, T; Saiz, C; Paz-Ganiel, I; Malcampo, M; Sánchez-Villegas, A; Salaverria-Lete, I; García-Arellano, A; Schröder, H; Salas-Salvadó, J, Universitat Rovira i Virgili, and Ni, JQ; Nishi, SK; Babio, N; Martínez-González, MA; Corella, D; Castañer, O; Martínez, JA; Alonso-Gómez, AM; Gómez-Gracia, E; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Martín-Sánchez, V; Pintó, X; Gaforio, JJ; Bustelo, AB; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Toledo, E; Coltell, O; Gómez-Martínez, C; Zomeño, MD; Donat-Vargas, C; Goicolea-Güemez, L; Bouzas, C; Garcia-de-la-Hera, M; Chaplin, A; Garcia-Rios, A; Casas, R; Cornejo-Pareja, I; Santos-Lozano, JM; Rognoni, T; Saiz, C; Paz-Ganiel, I; Malcampo, M; Sánchez-Villegas, A; Salaverria-Lete, I; García-Arellano, A; Schröder, H; Salas-Salvadó, J
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Scope Dairy consumption has been suggested to impact cognition; however, evidence is limited and inconsistent. This study aims to longitudinally assess the association between dairy consumption with cognitive changes in an older Spanish population at high cardiovascular disease risk. Methods and results Four thousand six hundred sixty eight participants aged 55-75 years, completed a validated food frequency questionnaire at baseline and a neuropsychological battery of tests at baseline and 2-year follow-up. Multivariable linear regression models are used, scaled by 100 (i.e., the units of beta correspond to 1 SD/100), to assess associations between baseline tertile daily consumption and 2-year changes in cognitive performance. Participants in the highest tertile of total milk and whole-fat milk consumption have a greater decline in global cognitive function (beta: -4.71, 95% CI: -8.74 to -0.69, p-trend = 0.020 and beta: -6.64, 95% CI: -10.81 to -2.47, p-trend = 0.002, respectively) compared to those in the lowest tertile. No associations are observed between low fat milk, yogurt, cheese or fermented dairy consumption, and changes in cognitive performance. Conclusion Results suggest there are no clear prospective associations between consumption of most commonly consumed dairy products and cognition, although there may be an association with a greater rate of cognitive decline over a 2-year period in older adults at high cardiovascular disease risk for whole-fat milk.
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- 2022
34. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
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Universitat Rovira i Virgili, Marhuenda-Muñoz M; Domínguez-López I; Langohr K; Tresserra-Rimbau A; Martínez González MÁ; Salas-Salvadó J; Corella D; Zomeño MD; Martínez JA; Alonso-Gómez AM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Bueno-Cavanillas A; Tur JA; Martín-Sánchez V; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Daimiel L; Ros E; Toledo E; Fernández de la Puente Cervera M; Barragán R; Fitó M; Tojal-Sierra L; Gómez-Gracia E; Zazo JM; Morey M; García-Ríos A; Casas R; Gómez-Pérez AM; Santos-Lozano JM; Vázquez-Ruiz Z; Atzeni A; Asensio EM; Gili-Riu MM; Bullon V; Moreno-Rodriguez A; Lecea O; Babio N; Peñas Lopez F; Gómez Melis G; Lamuela-Raventós RM, Universitat Rovira i Virgili, and Marhuenda-Muñoz M; Domínguez-López I; Langohr K; Tresserra-Rimbau A; Martínez González MÁ; Salas-Salvadó J; Corella D; Zomeño MD; Martínez JA; Alonso-Gómez AM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Bueno-Cavanillas A; Tur JA; Martín-Sánchez V; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Daimiel L; Ros E; Toledo E; Fernández de la Puente Cervera M; Barragán R; Fitó M; Tojal-Sierra L; Gómez-Gracia E; Zazo JM; Morey M; García-Ríos A; Casas R; Gómez-Pérez AM; Santos-Lozano JM; Vázquez-Ruiz Z; Atzeni A; Asensio EM; Gili-Riu MM; Bullon V; Moreno-Rodriguez A; Lecea O; Babio N; Peñas Lopez F; Gómez Melis G; Lamuela-Raventós RM
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Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].
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- 2022
35. Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial
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Universitat Rovira i Virgili, Tresserra-Rimbau A; Castro-Barquero S; Becerra-Tomás N; Babio N; Martínez-González MÁ; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gomez AM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Cano-Ibáñez N; Delgado-Rodríguez M; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; Vázquez C; Ros E; Basterra FJ; de la Puente MF; Asensio EM; Castañer O; Bullón-Vela V; Tojal-Sierra L; Gómez-Gracia E; Cases-Pérez E; Konieczna J; García-Ríos A; Casañas-Quintana T; Bernal-Lopez MR; Santos-Lozano JM; Esteve-Luque V; Bouzas C; Vázquez-Ruiz Z; Palau-Galindo A; Barragan R; Grau ML; Razquín C; Goicolea-Güemez L; Toledo E; Vergaz MV; Lamuela-Raventós RM; Salas-Salvadó J, Universitat Rovira i Virgili, and Tresserra-Rimbau A; Castro-Barquero S; Becerra-Tomás N; Babio N; Martínez-González MÁ; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gomez AM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Cano-Ibáñez N; Delgado-Rodríguez M; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; Vázquez C; Ros E; Basterra FJ; de la Puente MF; Asensio EM; Castañer O; Bullón-Vela V; Tojal-Sierra L; Gómez-Gracia E; Cases-Pérez E; Konieczna J; García-Ríos A; Casañas-Quintana T; Bernal-Lopez MR; Santos-Lozano JM; Esteve-Luque V; Bouzas C; Vázquez-Ruiz Z; Palau-Galindo A; Barragan R; Grau ML; Razquín C; Goicolea-Güemez L; Toledo E; Vergaz MV; Lamuela-Raventós RM; Salas-Salvadó J
- Abstract
Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a vali-dated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
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- 2022
36. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A ulti-Centre Population-Based Birth Cohort Study in Spain
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Universitat Rovira i Virgili, Tahaei H; Gignac F; Pinar A; Fernandez-Barrés S; Romaguera D; Vioque J; Santa-Marina L; Subiza-Pérez M; Llop S; Soler-Blasco R; Arija V; Salas-Salvadó J; Tardón A; Riaño-Galán I; Sunyer J; Guxens M; Julvez J, Universitat Rovira i Virgili, and Tahaei H; Gignac F; Pinar A; Fernandez-Barrés S; Romaguera D; Vioque J; Santa-Marina L; Subiza-Pérez M; Llop S; Soler-Blasco R; Arija V; Salas-Salvadó J; Tardón A; Riaño-Galán I; Sunyer J; Guxens M; Julvez J
- Abstract
Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child’s neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children’s Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/week) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/week) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI:-22.95,-0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and
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- 2022
37. Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis
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Universitat Rovira i Virgili, Micó V; San-Cristobal R; Martín R; Martínez-González MÁ; Salas-Salvadó J; Corella D; Fitó M; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem JL; Bueno-Cavanillas A; Tur JA; Martín Sánchez V; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; García-Arellano A; Pertusa-Martinez S; Chaplin A; Garcia-Rios A; Muñoz Bravo C; Schröder H; Babio N; Sorli JV; Gonzalez JI; Martinez-Urbistondo D; Toledo E; Bullón V; Ruiz-Canela M; Portillo MP; Macías-González M; Perez-Diaz-del-Campo N; García-Gavilán J; Daimiel L; Martínez JA, Universitat Rovira i Virgili, and Micó V; San-Cristobal R; Martín R; Martínez-González MÁ; Salas-Salvadó J; Corella D; Fitó M; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem JL; Bueno-Cavanillas A; Tur JA; Martín Sánchez V; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; García-Arellano A; Pertusa-Martinez S; Chaplin A; Garcia-Rios A; Muñoz Bravo C; Schröder H; Babio N; Sorli JV; Gonzalez JI; Martinez-Urbistondo D; Toledo E; Bullón V; Ruiz-Canela M; Portillo MP; Macías-González M; Perez-Diaz-del-Campo N; García-Gavilán J; Daimiel L; Martínez JA
- Abstract
Metabolic syndrome (MetS) is one of the most important medical problems around the world. Identification of patient´s singular characteristic could help to reduce the clinical impact and facilitate individualized management. This study aimed to categorize MetS patients using phenotypical and clinical variables habitually collected during health check-ups of individuals considered to have high cardiovascular risk. The selected markers to categorize MetS participants included anthropometric variables as well as clinical data, biochemical parameters and prescribed pharmacological treatment. An exploratory factor analysis was carried out with a subsequent hierarchical cluster analysis using the z-scores from factor analysis. The first step identified three different factors. The first was determined by hypercholesterolemia and associated treatments, the second factor exhibited glycemic disorders and accompanying treatments and the third factor was characterized by hepatic enzymes. Subsequently four clusters of patients were identified, where cluster 1 was characterized by glucose disorders and treatments, cluster 2 presented mild MetS, cluster 3 presented exacerbated levels of hepatic enzymes and cluster 4 highlighted cholesterol and its associated treatments Interestingly, the liver status related cluster was characterized by higher protein consumption and cluster 4 with low polyunsaturated fatty acid intake. This research emphasized the potential clinical relevance of hepatic impairments in addition to MetS traditional characterization for precision and personalized management of MetS patients.
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- 2022
38. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up
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Universitat Rovira i Virgili, Bouzas C; Bibiloni MdM; Garcia S; Mateos D; Martínez-González MÁ; Salas-Salvadó J; Corella D; Goday A; Martínez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; Lopez-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Riquelme-Gallego B; Martín-Sánchez V; Pintó X; Gaforio JJ; Matía P; Vidal J; Vázquez C; Daimiel L; Ros E; Pascual-Roquet-Jalmar E; Babio N; Gonzalez-Monge I; Castañer O; Abete I; Sorto-Sánchez C; Carlos Benavente-Marín J; Torres-Collado L; Martin M; García-Ríos A; Castro-Barquero S; Fernández-García JC; Santos-Lozano JM; Fernandez-Lazaro CI; Salas-Huetos A; Guillem-Saiz P; Zomeño MD; Ángeles Zulet M; Goikoetxea-Bahon A; Gea A; Nishi SK; Schröder H; Tur JA, Universitat Rovira i Virgili, and Bouzas C; Bibiloni MdM; Garcia S; Mateos D; Martínez-González MÁ; Salas-Salvadó J; Corella D; Goday A; Martínez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; Lopez-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Riquelme-Gallego B; Martín-Sánchez V; Pintó X; Gaforio JJ; Matía P; Vidal J; Vázquez C; Daimiel L; Ros E; Pascual-Roquet-Jalmar E; Babio N; Gonzalez-Monge I; Castañer O; Abete I; Sorto-Sánchez C; Carlos Benavente-Marín J; Torres-Collado L; Martin M; García-Ríos A; Castro-Barquero S; Fernández-García JC; Santos-Lozano JM; Fernandez-Lazaro CI; Salas-Huetos A; Guillem-Saiz P; Zomeño MD; Ángeles Zulet M; Goikoetxea-Bahon A; Gea A; Nishi SK; Schröder H; Tur JA
- Abstract
Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55–75 years old) with overweight or obesity at baseline. Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: ≥0.0 kg (T1, n = 1,638); 0.0 to −4.0 kg (T2, n = 1,903); ≤−4.0 kg (T3, n = 1,958). A food frequency questionnaire assessed diet and the Minnesota-REGICOR questionnaire assessed physical activity. The Framingham equation assessed cardiovascular risks. The changes in the severity of MetS were also assessed. The Beck Depression Inventory assessed depressive symptoms and the SF-36 assessed health-related quality of life. Data were analyzed using general linear models. Results: BMI decreased at T2 and T3 (T1: 0.3, T2: −0.7, T3: −1.9). The most significant improvement in diet quality was observed at T3. Cardiovascular risk decreased at T2 and T3. Mean reductions in MetS severity score were: −0.02 at T1, −0.39 at T2 and −0.78 at T3. The perception of physical health increases in successive tertiles. Conclusions: In older adults with MetS, more ambitious desired weight loss goals were associated with improvements in diet, cardiovascular health and perceived physic
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- 2022
39. Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study
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Universitat Rovira i Virgili, Garcia-Gavilan, JF; Paz-Graniel, I; Babio, N; Romaguera, D; Martinez, JA; Martin, V; Martinez, MA; Konieczna, J; Ruiz-Canela, M; Fernandez, JAD; Goday, A; Martinez-Gonzalez, MA; Bullo, M; Salas-Salvado, J, Universitat Rovira i Virgili, and Garcia-Gavilan, JF; Paz-Graniel, I; Babio, N; Romaguera, D; Martinez, JA; Martin, V; Martinez, MA; Konieczna, J; Ruiz-Canela, M; Fernandez, JAD; Goday, A; Martinez-Gonzalez, MA; Bullo, M; Salas-Salvado, J
- Abstract
Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55–75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: Participants in the top tertile of the M-DIS had a lower BMD at total femur [? (95% CI) ? 0.02 (? 0.04, ? 0.01)], trochanter areas [? (95% CI) ? 0.03 (? 0.05, ? 0.01)] and lumbar spine area [? (95% CI) ? 0.03 (? 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean popula
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- 2022
40. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
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Tahaei H, Gignac F, Pinar A, Fernandez-Barrés S, Romaguera D, Vioque J, Santa-Marina L, Subiza-Pérez M, Llop S, Soler-Blasco R, Arija V, Salas-Salvadó J, Tardón A, Riaño-Galán I, Sunyer J, Guxens M, and Julvez J
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children ,neurodevelopment ,omega-3 fatty acids ,maternal diet ,population-based cohort - Abstract
BACKGROUND: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. METHODS: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. RESULTS: Compared to participants in the lowest quartile (1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: -22.95, -0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. CONCLUSIONS: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.
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- 2022
41. Dietary inflammatory index and prostate cancer risk: MCC-Spain study
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Lozano-Lorca M, Salcedo-Bellido I, Olmedo-Requena R, Castaño-Vinyals G, Amiano P, Shivappa N, Hébert JR, Pérez-Gómez B, Gracia-Lavedan E, Gómez-Acebo I, Molina-Barceló A, Barrios-Rodríguez R, Alguacil J, Fernández-Tardón G, Aragonés N, Dierssen-Sotos T, Romaguera D, Pollán M, Kogevinas M, and Jiménez-Moleón JJ
- Abstract
BACKGROUND: The etiology of prostate cancer (PCa) is not well-known, and the role of diet is not well established. We aimed to evaluate the role of the inflammatory power of the diet, measured by the Dietary Inflammatory Index (DII (R)), on the risk of PCa. METHODOLOGY: A population-based multicase-control (MCC-Spain) study was conducted. Information was collected on sociodemographic characteristics, personal and family antecedents, and lifestyles, including diet from a Food Frequency Questionnaire. The inflammatory potential of the diet was assessed using the energy-adjusted Dietary Inflammatory Index (E-DII) based on 30 parameters (a higher score indicates a higher inflammatory capacity of the diet). Tertiles of E-DII were created using the cut-off points from the control group. The International Society of Urology Pathology (ISUP) was grouped as ISUP 1, ISUP 2, or ISUP 3-5. Unconditional logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between E-DII score and PCa risk. RESULTS: A total of 928 PCa cases and 1278 population controls were included. Among PCa cases, the mean value of the E-DII score was 0.18 (SD: 1.9) vs. 0.07 (SD: 1.9) in the control group (p = 0.162). Cases with a more pro-inflammatory diet (3rd tertile) had the highest risk of PCa, aOR(T3vsT1) = 1.30 (95% CI 1.03-1.65) (p-trend = 0.026). When stratifying by ISUP, this risk association was observed only for ISUP 2 and ISUP 3-5, aOR(T3vsT1) = 1.46 (95% CI 1.02-2.10) and 1.60 (95% CI 1.10-2.34), respectively. CONCLUSION: A positive association was observed between consuming a pro-inflammatory diet and PCa in the MCC-Spain population, specifically for an ISUP grade greater or equal than 2.
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- 2022
42. The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study
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Puig-Vallverdú J, Romaguera D, Fernández-Barrés S, Gignac F, Ibarluzea J, Santa-Maria L, Llop S, Gonzalez S, Vioque J, Riaño-Galán I, Fernández-Tardón G, Pinar A, Turner MC, Arija V, Salas-Savadó J, Vrijheid M, and Julvez J
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Industrialized foods ,Pregnancy ,Neurodevelopment ,Neuropsychological development ,Birth cohort ,Ultra-processed food - Abstract
Background & aims: Maternal ultra-processed food (UPF) consumption during pregnancy may adversely affect child development. Pregnancy sugar-sweetened beverage consumption (as a part of UPF) has been associated with child cognitive dysfunction in the general population, but the role of total UPF con-sumption during pregnancy in later child neuropsychological development has not been studied. We aimed to analyse the association between maternal pregnancy UPF consumption and child neurodevelopment.Methods: This study involved 2377 pairs of pregnant women and their offspring from a Spanish birth cohort (recruitment period: 2004e20 08, INMA project). Dietary intake was estimated using a 101-item food frequency questionnaire in the third trimester of pregnancy. The NOVA classification was used to identify UPFs, and their consumption was calculated as the daily percentage of total food consumption and categorized into tertiles. Child neuropsychological development was assessed with the Bayley Scales of Infant and Toddler Development (1-year-old, n = 1929) and the McCarthy Scales of Children's Abilities (4-5 years-old, n = 1679). Potential associations were analysed using multivariate linear regression models adjusted for a range of family and child characteristics.Results: UPF consumption among pregnant women represented an average of 17% of the total diet, with sugar-sweetened beverages being the most commonly consumed type of UPF (40%). Children born to mothers in the highest tertile of UPF consumption (28.9% or more of the total diet) vs the lowest tertile (7.2% or less), showed a lower score (B =-2.29 [95% Confidence Interval (CI),-4.13;-0.46]) in the Verbal Scale of the McCarthy Scales (p-for-trend = 0.02). No associations were observed with the McCarthy Scales assessing other cognitive domains or with the Bayley Scales.Conclusion: Of the seven cognitive domains studied, we observed an adverse association between maternal consumption of UPF during pregnancy and verbal functioning in early childhood, which is an important cognitive domain of neurodevelopment.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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- 2022
43. Nutritional Assessment of Patients Affected by Porphyria Variegata
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Romaguera, D., Puigros, M.A., Palacin, C., Pons, A., and Tur, J.A.
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- 2006
44. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence among Patients with Metabolic Syndrome: Interim Analysis of the PREDIMED-Plus Randomized Clinical Trial
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Sayón-Orea C; Razquin C; Bulló M; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Bueno-Cavanillas A; Delgado-Rodríguez M; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; Vázquez C; Ros E; Ruiz-Canela M; Sorlí JV; Castañer O; Fiol M; Navarrete-Muñoz EM; Arós F; Gómez-Gracia E; Zulet MA; Sánchez-Villegas A; Casas R; Bernal-López R; Santos-Lozano JM; Corbella E; Bouzas C; García-Arellano A; Sayón-Orea C; Razquin C; Bulló M; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and Sayón-Orea C; Razquin C; Bulló M; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Bueno-Cavanillas A; Delgado-Rodríguez M; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; Vázquez C; Ros E; Ruiz-Canela M; Sorlí JV; Castañer O; Fiol M; Navarrete-Muñoz EM; Arós F; Gómez-Gracia E; Zulet MA; Sánchez-Villegas A; Casas R; Bernal-López R; Santos-Lozano JM; Corbella E; Bouzas C; García-Arellano A; Sayón-Orea C; Razquin C; Bulló M; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L
- Abstract
© 2019 American Medical Association. All rights reserved. Importance: High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes. Objective: To assess the effect of a nutritional and physical activity education program on dietary quality. Design, Setting, and Participants: Preliminary exploratory interim analysis of an ongoing randomized trial. In 23 research centers in Spain, 6874 men and women aged 55 to 75 years with metabolic syndrome and no cardiovascular disease were enrolled in the trial between September 2013 and December 2016, with final data collection in March 2019. Interventions: Participants were randomized to an intervention group that encouraged an energy-reduced Mediterranean diet, promoted physical activity, and provided behavioral support (n = 3406) or to a control group that encouraged an energy-unrestricted Mediterranean diet (n = 3468). All participants received allotments of extra-virgin olive oil (1 L/mo) and nuts (125 g/mo) for free. Main Outcomes and Measures: The primary outcome was 12-month change in adherence based on the energy-reduced Mediterranean diet (er-MedDiet) score (range, 0-17; higher scores indicate greater adherence; minimal clinically important difference, 1 point). Results: Among 6874 randomized participants (mean [SD] age, 65.0 [4.9] years; 3406 [52%] men), 6583 (96%) completed the 12-month follow-up and were included in the main analysis. The mean (SD) er-MedDiet score was 8.5 (2.6) at baseline and 13.2 (2.7) at 12 months in the intervention group (increase, 4.7 [95% CI, 4.6-4.8]) and 8.6 (2.7) at baseline and 11.1 (2.8) at 12 months in the control group (increase, 2.5 [95% CI, 2.3-2.6]) (between
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- 2019
45. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study
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Ferrari, P, McKay, J D, Jenab, M, Brennan, P, Canzian, F, Vogel, U, Tjønneland, A, Overvad, K, Tolstrup, J S, Boutron-Ruault, M-C, Clavel-Chapelon, F, Morois, S, Kaaks, R, Boeing, H, Bergmann, M, Trichopoulou, A, Katsoulis, M, Trichopoulos, D, Krogh, V, Panico, S, Sacerdote, C, Palli, D, Tumino, R, Peeters, P H, van Gils, C H, Bueno-de-Mesquita, B, Vrieling, A, Lund, E, Hjartåker, A, Agudo, A, Suarez, L R, Arriola, L, Chirlaque, M-D, Ardanaz, E, Sánchez, M-J, Manjer, J, Lindkvist, B, Hallmans, G, Palmqvist, R, Allen, N, Key, T, Khaw, K-T, Slimani, N, Rinaldi, S, Romieu, I, Boffetta, P, Romaguera, D, Norat, T, and Riboli, E
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- 2012
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46. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study (Aug, 10.1007/s00394-020-02364-4, 2020)
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Navarrete-Munoz E, Vioque J, Toledo E, Oncina-Canovas A, Martinez-Gonzalez M, Salas-Salvado J, Corella D, Fito M, Romaguera D, Alonso-Gomez A, Warnberg J, Martinez J, Serra-Majem L, Estruch R, Tinahones F, Lapetra J, Pinto X, Tur J, Lopez-Miranda J, Bueno-Cavanillas A, Matia-Martin P, Daimiel L, Sanchez V, Vidal J, Blanco A, Ros E, Diez-Espino J, Babio N, Fernandez-Carrion R, Castaner O, Colom A, Compan-Gabucio L, Lete I, Crespo-Oliva E, Abete I, Tomaino L, Casas R, Fernandez-Garcia J, Santos-Lozano J, Sarasa I, Gamez J, Garcia-Rios J, Martin-Pelaez S, Ruiz-Canela M, Diaz-Lopez A, Martinez-Lacruz R, Zomeno M, Rayo E, Selles C, Canudas S, Goday A, and Garcia-de-la-Hera M
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- 2021
47. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population
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Paz-Graniel, I, Babio, N, Becerra-Tomas, N, Toledo, E, Camacho-Barcia, L, Corella, D, Castaner-Nino, O, Romaguera, D, Vioque, J, Alonso-Gomez, AM, Warnberg, J, Martinez, JA, Serra-Majem, L, Estruch, R, Tinahones, FJ, Fernandez-Aranda, F, Lapetra, J, Pinto, X, Tur, JA, Garcia-Rios, A, Bueno-Cavanillas, A, Gaforio, JJ, Matia-Martin, P, Daimiel, L, Sanchez, VM, Vidal, J, Prieto-Sanchez, L, Ros, E, Razquin, C, Mestres, C, Sorli, JV, Cuenca-Royo, AM, Rios, A, Torres-Collado, L, Vaquero-Luna, J, Perez-Farinos, N, Zulet, MA, Sanchez-Villegas, A, Casas, R, Bernal-Lopez, MR, Santos-Lozano, JM, Corbella, X, Mateos, D, Buil-Cosiales, P, Jimenez-Murcia, S, Fernandez-Carrion, R, Forcano-Gamazo, L, Lopez, M, Sempere-Pascual, MA, Moreno-Rodriguez, A, Gea, A, De la Torre-Fornell, R, Salas-Salvado, J, Perez, A, and Lozano Madrid, Maria
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Cognitive impairment ,Caffeine ,Mini-Mental State Examination ,PREDIMED-plus ,Coffee - Abstract
Purpose Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS). Methods PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n = 6427; mean age = 65 +/- 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment. Results Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A). Conclusions Coffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS.
- Published
- 2021
48. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
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Zhou, B, Carrillo-Larco, Rm, Danaei, G, Riley, Lm, Paciorek, Cj, Stevens, Ga, Gregg, Ew, Bennett, Je, Solomon, B, Singleton, Rk, Sophiea, Mk, Iurilli, Mlc, Lhoste, Vpf, Cowan, Mj, Savin, S, Woodward, M, Balanova, Y, Cifkova, R, Damasceno, A, Elliott, P, Farzadfar, F, He, J, Ikeda, N, Kengne, Ap, Khang, Yh, Kim, Hc, Laxmaiah, A, Lin, Hh, Maira, Pm, Miranda, Jj, Neuhauser, H, Sundstrom, J, Varghese, C, Widyahening, Is, Zdrojewski, T, Ezzati, M, Abarca-Gomez, L, Abdeen, Za, Rahim, Hfa, Abu-Rmeileh, Nm, Acosta-Cazares, B, Adams, Rj, Aekplakorn, W, Afsana, K, Afzal, S, Agdeppa, Ia, Aghazadeh-Attari, J, Aguilar-Salinas, Ca, Agyemang, C, Ahmad, Na, Ahmadi, A, Ahmadi, N, Ahmadizar, F, Ahmed, Sh, Ahrens, W, Ajlouni, K, Al-Raddadi, R, Alarouj, M, Albuhairan, F, Aldhukair, S, Ali, Mm, Alkandari, A, Alkerwi, A, Allin, K, Aly, E, Amarapurkar, Dn, Amougou, N, Amouyel, P, Andersen, Lb, Anderssen, Sa, Anjana, Rm, Ansari-Moghaddam, A, Ansong, D, Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, Re, Arlappa, N, Aryal, Kk, Aspelund, T, Assah, Fk, Assuncao, Mcf, Auvinen, J, Avdicova, M, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, Bv, Bahijri, S, Balakrishna, N, Bamoshmoosh, M, Banach, M, Banadinovic, M, Bandosz, P, Banegas, Jr, Baran, J, Barbagallo, Cm, Barcelo, A, Barkat, A, Barreto, M, Barros, Ajd, Barros, Mvg, Bartosiewicz, A, Basit, A, Bastos, Jld, Bata, I, Batieha, Am, Batyrbek, A, Baur, La, Beaglehole, R, Belavendra, A, Ben Romdhane, H, Benet, M, Benson, Ls, Berkinbayev, S, Bernabe-Ortiz, A, Bettiol, H, Bezerra, J, Bhagyalaxmi, A, Bhargava, Sk, Bia, D, Biasch, K, Lele, Ecb, Bikbov, Mm, Bista, B, Bjerregaard, P, Bjertness, E, Bjertness, Mb, Bjorkelund, C, Bloch, Kv, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, Jg, Boissonnet, Cp, Bojesen, Se, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boyer, Cb, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, Lm, Briceno, Y, Brito, M, Bruno, G, Bueno-de-Mesquita, Hb, Bueno, G, Bugge, A, Burns, C, Bursztyn, M, de Leon, Ac, Cacciottolo, J, Cameron, C, Can, G, Candido, Apc, Capanzana, Mv, Capkova, N, Capuano, E, Capuano, V, Cardoso, Vc, Carlsson, Ac, Carvalho, J, Casanueva, Ff, Censi, L, Cervantes-Loaiza, M, Chadjigeorgiou, Ca, Chamukuttan, S, Chan, Aw, Chan, Q, Chaturvedi, Hk, Chaturvedi, N, Chee, Ml, Chen, Cj, Chen, Ff, Chen, Hs, Chen, Sh, Chen, Zm, Cheng, Cy, Cheraghian, B, Dekkaki, Ic, Chetrit, A, Chien, Kl, Chiolero, A, Chiou, St, Chirita-Emandi, A, Chirlaque, Md, Cho, B, Christensen, K, Christofaro, Dg, Chudek, J, Cinteza, E, Claessens, F, Clarke, J, Clays, E, Cohen, E, Concin, H, Cooper, C, Coppinger, Tc, Costanzo, S, Cottel, D, Cowell, C, Craig, Cl, Crampin, Ac, Crujeiras, Ab, Cruz, Jj, Csilla, S, Cui, Lf, Cureau, Fv, Cuschieri, S, D'Arrigo, G, D'Orsi, E, Dallongeville, J, Dankner, R, Dantoft, Tm, Dauchet, L, Davletov, K, De Backer, G, De Bacquer, D, De Curtis, A, de Gaetano, G, De Henauw, S, de Oliveira, Pd, De Ridder, D, De Smedt, D, Deepa, M, Deev, Ad, Degennaro, V, Delisle, H, Demarest, S, Dennison, E, Deschamps, V, Dhimal, M, Di Castelnuovo, Af, Dias-da-Costa, Js, Diaz, A, Dickerson, Tt, Dika, Z, Djalalinia, S, Htp, Do, Dobson, Aj, Donfrancesco, C, Donoso, Sp, Doring, A, Dorobantu, M, Dorr, M, Doua, K, Dragano, N, Drygas, W, Duante, Ca, Duboz, P, Duda, Rb, Dulskiene, V, Dushpanova, A, Dzakula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eddie, R, Eftekhar, E, Eggertsen, R, Eghtesad, S, Eiben, G, Ekelund, U, El-Khateeb, M, El Ati, J, Eldemire-Shearer, D, Eliasen, M, Elosua, R, Erasmus, Rt, Erbel, R, Erem, C, Eriksen, L, Eriksson, Jg, Escobedo-de la Pena, J, Eslami, S, Esmaeili, A, Evans, A, Faeh, D, Fakhretdinova, Aa, Fall, Ch, Faramarzi, E, Farjam, M, Fattahi, Mr, Fawwad, A, Felix-Redondo, Fj, Felix, Sb, Ferguson, Ts, Fernandes, Ra, Fernandez-Berges, D, Ferrante, D, Ferrao, T, Ferrari, M, Ferrario, Mm, Ferreccio, C, Ferreira, Hs, Ferrer, E, Ferrieres, J, Figueiro, Th, Fink, G, Fischer, K, Foo, Lh, Forsner, M, Fouad, Hm, Francis, Dk, Grego, Franco, Frikke-Schmidt, R, Frontera, G, Fuchs, Fd, Fuchs, Sc, Fujita, Y, Fumihiko, M, Furdela, V, Furer, A, Furusawa, T, Gaciong, Z, Galbarczyk, A, Galenkamp, H, Galvano, F, Gao, Jl, Gao, P, Garcia-de-la-Hera, M, Garcia, P, Gareta, D, Garnett, Sp, Gaspoz, Jm, Gasull, M, Gazzinelli, A, Gehring, U, Geleijnse, Jm, George, R, Ghanbari, A, Ghasemi, E, Gheorghe-Fronea, Of, Ghimire, A, Gialluisi, A, Giampaoli, S, Gieger, C, Gill, Tk, Giovannelli, J, Gironella, G, Giwercman, A, Gkiouras, K, Goldberg, M, Goldsmith, Ra, Gomez, Lf, Gomula, A, da Silva, Bgc, Goncalves, H, Goncalves, M, Gonzalez-Chica, Da, Gonzalez-Gross, M, Gonzalez-Rivas, Jp, Gonzalez-Villalpando, C, Gonzalez-Villalpando, Me, Gonzalez, Ar, Gorbea, Mb, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Grammatikopoulou, Mg, Gregor, Rd, Grodzicki, T, Grosso, G, Gruden, G, Df, Gu, Guan, Op, Gudmundsson, Ef, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, Al, Gulliford, Mc, Gunnlaugsdottir, J, Gunter, Mj, Gupta, Pc, Gupta, R, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Ha, S, Hadaegh, F, Haghshenas, R, Hakimi, H, Halkjaer, J, Hambleton, Ir, Hamzeh, B, Hange, D, Hanif, Aam, Hantunen, S, Hao, J, Hardman, Cm, Kumar, Rh, Hashemi-Shahri, Sm, Hata, J, Haugsgjerd, T, Hayes, Aj, Yn, He, Heier, M, Hendriks, Me, Henrique, Rd, Henriques, A, Cadena, Lh, Herrala, S, Heshmat, R, Hill, Ag, Sy, Ho, Sc, Ho, Hobbs, M, Holdsworth, M, Homayounfar, R, Dinc, Gh, Horimoto, Arvr, Hormiga, Cm, Horta, Bl, Houti, L, Howitt, C, Htay, Tt, Htet, As, Htike, Mmt, Yh, Hu, Huerta, Jm, Huhtaniemi, It, Huiart, L, Huisman, M, Husseini, As, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, Ag, Ibrahim, Mm, Wong, Ni, Ikram, Ma, Iotova, V, Irazola, Ve, Ishida, T, Isiguzo, Gc, Islam, M, Islam, Sms, Iwasaki, M, Jackson, Rt, Jacobs, Jm, Jaddou, Hy, Jafar, T, James, K, Jamrozik, K, Janszky, I, Janus, E, Jarvelin, Mr, Jasienska, G, Jelakovic, A, Jelakovic, B, Jennings, G, Jha, Ak, Jiang, Cq, Jimenez, Ro, Jockel, Kh, Joffres, M, Johansson, M, Jokelainen, Jj, Jonas, Jb, Jorgensen, T, Joshi, P, Joukar, F, Jozwiak, J, Juolevi, A, Jurak, G, Juresa, V, Kaaks, R, Kafatos, A, Kajantie, Eo, Kalmatayeva, Z, Kalpourtzi, N, Kalter-Leibovici, O, Kampmann, Fb, Kannan, S, Karaglani, E, Karhus, Ll, Karki, Kb, Katibeh, M, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, Gm, Keil, U, Boker, Lk, Keinanen-Kiukaanniemi, S, Kelishadi, R, Kemper, Hcg, Keramati, M, Kerimkulova, A, Kersting, M, Key, T, Khader, Ys, Khalili, D, Khaw, Kt, Kheiri, B, Kheradmand, M, Khosravi, A, Kiechl-Kohlendorfer, U, Kiechl, S, Killewo, J, Kim, Dw, Kim, J, Klakk, H, Klimek, M, Klumbiene, J, Knoflach, M, Kolle, E, Kolsteren, P, Kontto, Jp, Korpelainen, R, Korrovits, P, Kos, J, Koskinen, S, Kouda, K, Kowlessur, S, Koziel, S, Kratenova, J, Kriaucioniene, V, Kristensen, Pl, Krokstad, S, Kromhout, D, Kruger, Hs, Kubinova, R, Kuciene, R, Kujala, Um, Kulaga, Z, Kumar, Rk, Kurjata, P, Kusuma, Ys, Kutsenko, V, Kuulasmaa, K, Kyobutungi, C, Laatikainen, T, Lachat, C, Laid, Y, Lam, Th, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Latt, Ts, Le Coroller, G, Bao, Kln, Le, THUY DUNG, Lee, J, Lehmann, N, Lehtimaki, T, Lemogoum, D, Levitt, Ns, Yp, Li, Lilly, Cl, Lim, Wy, Lima-Costa, Mf, Lin, X, Lin, Yt, Lind, L, Lingam, V, Linneberg, A, Lissner, L, Litwin, M, Wc, Lo, Loit, Hm, Lopez-Garcia, E, Lopez, T, Lotufo, Pa, Lozano, Je, Lovrencic, Il, Lukrafka, Jl, Luksiene, D, Lundqvist, A, Lundqvist, R, Lunet, N, Lustigova, M, Luszczki, E, Gs, Ma, Ma, J, Machado-Coelho, Gll, Machado-Rodrigues, Am, Macia, E, Macieira, Lm, Madar, Aa, Maggi, S, Magliano, Dj, Magriplis, E, Mahasampath, G, Maire, B, Majer, M, Makdisse, M, Malekzadeh, F, Malekzadeh, R, Malhotra, R, Mallikharjuna, K, Malyutina, Sk, Maniego, Lv, Manios, Y, Mann, Ji, Mansour-Ghanaei, F, Manzato, E, Marcil, A, Margozzini, P, Marild, Sb, Glavic, Mm, Marques-Vidal, P, Marques, Lp, Marrugat, J, Martorell, R, Mascarenhas, Lp, Matasin, M, Mathiesen, Eb, Mathur, P, Matijasevich, A, Matlosz, P, Matsha, Te, Mavrogianni, C, Mbanya, Jcn, Posso, Ajm, Mcfarlane, Sr, Mcgarvey, St, Mclachlan, S, Mclean, Rm, Mclean, Sb, Mcnulty, Ba, Benchekor, Sm, Medzioniene, J, Mehdipour, P, Mehlig, K, Mehrparvar, Ah, Meirhaeghe, A, Meisinger, C, Montano, Cm, Menezes, Amb, Menon, Gr, Mereke, A, Meshram, Ii, Metspalu, A, Meyer, He, Mi, J, Michels, N, Mikkel, K, Milkowska, K, Miller, Jc, Minderico, Cs, Mini, Gk, Mirjalili, Mr, Mirrakhimov, E, Misigoj-Durakovic, M, Modesti, Pa, Moghaddam, Ss, Mohajer, B, Mohamed, Mk, Mohamed, Sf, Mohammad, K, Mohammadi, Mr, Mohammadi, Z, Mohammadifard, N, Mohammadpourhodki, R, Mohan, V, Mohanna, S, Yusoff, Mfm, Mohebbi, I, Mohebi, F, Moitry, M, Mollehave, Lt, Molnar, D, Momenan, A, Mondo, Ck, Monterrubio-Flores, E, Monyeki, Kdk, Moon, Js, Moosazadeh, M, Moreira, Lb, Morejon, A, Moreno, La, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mostafavi, Sa, Mota, J, Motlagh, Me, Motta, J, Moura-dos-Santos, Ma, Mridha, Mk, Msyamboza, Kp, Tt, Mu, Muhihi, Aj, Muiesan, Ml, Muller-Nurasyid, M, Murphy, N, Mursu, J, Musa, Ki, Milanovic, Sm, Musil, V, Mustafa, N, Nabipour, I, Naderimagham, S, Nagel, G, Naidu, Bm, Najafi, F, Nakamura, H, Namesna, J, Nang, Eek, Nangia, Vb, Narake, S, Ndiaye, Nc, Neal, Wa, Nejatizadeh, A, Nenko, I, Neovius, M, Neuhauser, Hk, Nguyen, Ct, Nguyen, Nd, Nguyen, Qv, Nguyen, Qn, Nieto-Martinez, Re, Niiranen, Tj, Nikitin, Yp, Ninomiya, T, Nishtar, S, Njelekela, Ma, Noale, M, Noboa, Oa, Noorbala, Aa, Norat, T, Nordendahl, M, Nordestgaard, Bg, Noto, D, Nowak-Szczepanska, N, Al Nsour, M, Nunes, B, O'Neill, Tw, O'Reilly, D, Ochimana, C, Oda, E, Odili, An, Oh, K, Ohara, K, Ohtsuka, R, Olie, V, Olinto, Mta, Oliveira, Io, Omar, Ma, Onat, A, Ong, Sk, Ono, Lm, Ordunez, P, Ornelas, R, Ortiz, Pj, Osmond, C, Ostojic, Sm, Ostovar, A, Otero, Ja, Overvad, K, Owusu-Dabo, E, Paccaud, Fm, Padez, C, Pahomova, E, de Paiva, Km, Pajak, A, Palli, D, Palmieri, L, Pan, Wh, Panda-Jonas, S, Panza, F, Paoli, M, Papandreou, D, Park, Sw, Park, S, Parnell, Wr, Parsaeian, M, Pasquet, P, Patel, Nd, Pavlyshyn, H, Pecin, I, Pednekar, Ms, Pedro, Jm, Peer, N, Peixoto, Sv, Peltonen, M, Pereira, Ac, Peres, Kgda, Peres, Ma, Peters, A, Petkeviciene, J, Peykari, N, Pham, St, Pichardo, Rn, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Piwonska, A, Pizarro, An, Plans-Rubio, P, Polasek, O, Porta, M, Poudyal, A, Pourfarzi, F, Pourshams, A, Poustchi, H, Pradeepa, R, Price, Aj, Price, Jf, Providencia, R, Puhakka, Se, Puiu, M, Punab, M, Qasrawi, Rf, Qorbani, M, Queiroz, D, Bao, Tq, Radic, I, Radisauskas, R, Rahimikazerooni, S, Rahman, M, Raitakari, O, Raj, M, Rakhimova, Em, Rao, Sr, Ramachandran, A, Ramos, E, Rampal, L, Rampal, S, Reina, Dar, Rarra, V, Rech, Cr, Redon, J, Reganit, Pfm, Regecova, V, Revilla, L, Rezaianzadeh, A, Ribeiro, R, Riboli, E, Richter, A, Rigo, F, de Wit, Tfr, Ritti-Dias, Rm, Robitaille, C, Rodriguez-Artalejo, F, Rodriguez-Perez, Md, Rodriguez-Villamizar, La, Roggenbuck, U, Rojas-Martinez, R, Romaguera, D, Romeo, El, Rosengren, A, Roy, Jgr, Rubinstein, A, Ruidavets, Jb, Ruiz-Betancourt, Bs, Ruiz-Castell, M, Rusakova, Ia, Russo, P, Rutkowski, M, Sabanayagam, C, Sabbaghi, H, Sachdev, Hs, Sadjadi, A, Safarpour, Ar, Safi, S, Safiri, S, Saidi, O, Sakarya, S, Saki, N, Salanave, B, Martinez, Es, Salmeron, D, Salomaa, V, Salonen, Jt, Salvetti, M, Sanchez-Abanto, J, Sans, S, Santos, Da, Santos, Is, Santos, Lc, Santos, Mp, Santos, R, Saramies, Jl, Sardinha, Lb, Sarganas, G, Sarrafzadegan, N, Sathish, T, Saum, Ku, Savva, S, Sawada, N, Sbaraini, M, Scazufca, M, Schaan, Bd, Schargrodsky, H, Schipf, S, Schmidt, Co, Schnohr, P, Schottker, B, Schramm, S, Schultsz, C, Schutte, Ae, Sebert, S, Sein, Aa, Sen, A, Senbanjo, Io, Sepanlou, Sg, Servais, J, Shalnova, Sa, Shamah-Levy, T, Shamshirgaran, M, Shanthirani, Cs, Sharafkhah, M, Sharma, Sk, Shaw, Je, Shayanrad, A, Shayesteh, Aa, Shi, Zm, Shibuya, K, Shimizu-Furusawa, H, Shin, Dw, Shirani, M, Shiri, R, Shrestha, N, Si-Ramlee, K, Siani, A, Siantar, R, Sibai, Am, Silva, Crd, Silva, Das, Simon, M, Simons, J, Simons, La, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Hk, So, Soares, Fc, Sobngwi, E, Soderberg, S, Soemantri, A, Sofat, R, Solfrizzi, V, Somi, Mh, Sonestedt, E, Song, Y, Sorensen, Tia, Sorgjerd, Ep, Soric, M, Jerome, Cs, Soumare, A, Sparboe-Nilsen, B, Sparrenberger, K, Staessen, Ja, Starc, G, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, Ad, Stergiou, Gs, Stessman, J, Stieber, J, Stockl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, Mw, Suka, M, Sun, Ca, Sung, Yt, Suriyawongpaisal, P, Rg, Sy, Syddall, He, Sylva, Rc, Szklo, M, Tai, Es, Tammesoo, Ml, Tamosiunas, A, Tan, Ej, Tang, X, Tanser, F, Tao, Y, Tarawneh, Mr, Tarqui-Mamani, Cb, Taylor, A, Taylor, J, Tebar, Wr, Tell, Gs, Tello, T, Tham, Yc, Thankappan, Kr, Theobald, H, Theodoridis, X, Thijs, L, Thinggaard, M, Thomas, N, Thorand, B, Thuesen, Bh, Timmermans, Ej, Tjandrarini, Dh, Tjonneland, A, Toft, U, Tolonen, Hk, Tolstrup, Js, Topbas, M, Topor-Madry, R, Tormo, Mj, Tornaritis, Mj, Torrent, M, Torres-Collado, L, Touloumi, G, Traissac, P, Triantafyllou, A, Trichopoulos, D, Trichopoulou, A, Trinh, Oth, Trivedi, A, Tshepo, L, Tsugane, S, Tuliakova, Am, Tulloch-Reid, Mk, Tullu, F, Tuomainen, Tp, Tuomilehto, J, Turley, Ml, Twig, G, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, Hmt, Valdivia, G, Valvi, D, van Dam, Rm, van den Born, Bj, Van der Heyden, J, van der Schouw, Yt, Van Herck, K, Minh, Hv, Van Schoor, Nm, van Valkengoed, Igm, van Zutphen, Em, Vanderschueren, D, Vanuzzo, D, Varbo, A, Vasan, Sk, Vega, T, Veidebaum, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, Wmm, Verstraeten, R, Victora, Cg, Viet, L, Villalpando, S, Vineis, P, Vioque, J, Virtanen, Jk, Visvikis-Siest, S, Viswanathan, B, Vlasoff, T, Vollenweider, P, Voutilainen, A, Wade, An, Walton, J, Wambiya, Eoa, Bebakar, Wmw, Mohamud, Wnw, Wanderley, Rd, Wang, Md, Wang, Nl, Wang, Q, Wang, Xj, Wang, Yx, Wang, Yw, Wannamethee, Sg, Wareham, N, Wei, Wb, Weres, A, Werner, B, Whincup, Ph, Widhalm, K, Wiecek, A, Wilks, Rj, Willeit, J, Willeit, P, Williams, Ea, Wilsgaard, T, Wojtyniak, B, Wong-McClure, Ra, Wong, A, Wong, Ty, Woo, J, Fc, Wu, Sl, Wu, Wyszynska, J, Hq, Xu, Xu, L, Yaacob, Na, Yan, Wl, Yang, L, Yang, Xg, Yang, Y, Yasuharu, T, Xw, Ye, Yiallouros, Pk, Yoosefi, M, Yoshihara, A, You, Sl, Younger-Coleman, No, Yusoff, Af, Zainuddin, Aa, Zakavi, Sr, Zamani, F, Zambon, S, Zampelas, A, Zapata, Me, Zaw, Kk, Zejglicova, K, Vrkic, Tz, Zeng, Y, Zhang, Lx, Zhang, Zy, Zhao, D, Zhao, Mh, Zhen, Sq, Zheng, Yf, Zholdin, B, Zhu, D, Zins, M, Zitt, E, Zocalo, Y, Zoghlami, N, Cisneros, Jz, Borghs, Herman, Claessens, Frank, Staessen, Jan, Thijs, Lutgarde, Vanderschueren, Dirk, Zhang, Zhen-Yu, Imperial Coll London, Harvard TH Chan Sch Publ Hlth, WHO, Univ Calif Berkeley, Univ New South Wales, Natl Med Res Ctr Therapy & Prevent Med, Charles Univ Prague, Thomayer Hosp, Eduardo Mondlane Univ, Noncommunicable Dis Res Ctr, Tulane Univ, Natl Inst Biomed 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Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc J Gunter, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Seongjun Ha, Farzad Hadaegh, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R Hambleton, Behrooz Hamzeh, Dominique Hange, Abu Am Hanif, Sari Hantunen, Jie Hao, Carla Menêses Hardman, Rachakulla Hari Kumar, Seyed Mohammad Hashemi-Shahri, Jun Hata, Teresa Haugsgjerd, Alison J Hayes, Yuna He, Margit Heier, Marleen Elisabeth Hendriks, Rafael Dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Herqutanto, Sauli Herrala, Ramin Heshmat, Allan G Hill, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Michelle Holdsworth, Reza Homayounfar, Gonul Horasan Dinc, Andrea Rvr Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Martijn Huisman, Abdullatif S Husseini, Inge 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Mansour-Ghanaei, Enzo Manzato, Anie Marcil, Staffan B Mårild, Mihalea Marinović Glavić, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Luis P Mascarenhas, Marija Matasin, Ellisiv B Mathiesen, Prashant Mathur, Alicia Matijasevich, Piotr Matlosz, Tandi E Matsha, Christina Mavrogianni, Jean Claude N Mbanya, Anselmo J Mc Donald Posso, Shelly R McFarlane, Stephen T McGarvey, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Christa Meisinger, Carlos Mendoza Montano, Ana Maria B Menezes, Geetha R Menon, Alibek Mereke, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C Miller, Cláudia S Minderico, G K Mini, Mohammad Reza Mirjalili, Erkin Mirrakhimov, Marjeta Mišigoj-Duraković, Pietro A Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K 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D. A., Peres, Marco A., Peters, Annette, Petkeviciene, Janina, Peykari, Niloofar, Son Thai Pham, Pichardo, Rafael N., Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia N., Plans-Rubio, Pedro, Polasek, Ozren, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J., Price, Jacqueline F., Providencia, Rui, Puhakka, Soile E., Puiu, Maria, Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Queiroz, Daniel, Tran Quoc Bao, Radic, Ivana, Radisauskas, Ricardas, Rahimikazerooni, Salar, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Rakhimova, Ellina M., Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Lekhraj, Rampal, Sanjay, Rangel Reina, Daniel A., Rarra, Vayia, Rech, Cassiano Ricardo, Redon, Josep, Reganit, Paul Ferdinand M., Regecova, Valeria, Revilla, Luis, Rezaianzadeh, Abbas, Ribeiro, Robespierre, Riboli, Elio, Richter, Adrian, Rigo, Fernando, de Wit, Tobias F. 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Goya, Wareham, Nicholas, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H., Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Willeit, Peter, Williams, Emmanuel A., Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A., Wong, Andrew, Wong, Tien Yin, Woo, Jean, Wu, Frederick C., Wu, Shouling, Wyszynska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K., Yoosefi, Moein, Yoshihara, Akihiro, You, San-Lin, Younger-Coleman, Novie O., Yusoff, Ahmad Faudzi, Zainuddin, Ahmad A., Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Elisa Zapata, Maria, Zaw, Ko Ko, Zejglicova, Kristyna, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhao, Dong, Zhao, Ming-Hui, Zhen, Shiqi, Zheng, Yingfeng, Zholdin, Bekbolat, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuniga Cisneros, Julio., School of Medicine, ACS - Diabetes & metabolism, APH - Global Health, Pulmonology, Medical Informatics, Adult Psychiatry, Global Health, APH - Quality of Care, APH - Methodology, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Anesthesiology, Graduate School, and ACS - Heart failure & arrhythmias
- Subjects
Male ,Latin Americans ,Nutrition and Disease ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Medizin ,BLOOD-PRESSURE ,030204 cardiovascular system & hematology ,Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants ,Hypertension ,Prevalence ,Control ,Tretament ,GUIDELINES ,Global Health ,Worldwide trends ,0302 clinical medicine ,Hypertension prevalence ,Voeding en Ziekte ,Medicine and Health Sciences ,kohonnut verenpaine ,Medicine ,030212 general & internal medicine ,Prevention and Control ,11 Medical and Health Sciences ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,food and beverages ,Public Health, Global Health, Social Medicine and Epidemiology ,General Medicine ,Noncommunicable diseases ,Period prevalence ,Middle Aged ,kansainvälinen vertailu ,3142 Public health care science, environmental and occupational health ,3. Good health ,MIDDLE-INCOME ,Pooled analysis ,SYSTEMATIC ANALYSIS ,INCOME COUNTRIES ,ADULTS ,PREVENTION ,MANAGEMENT ,ADHERENCE ,DIAGNOSIS ,Western europe ,[SDE]Environmental Sciences ,Hypertension/diagnosis ,NCD Risk Factor Collaboration (NCD-RisC) ,Female ,B990 Subjects Allied to Medicine not elsewhere classified ,Life Sciences & Biomedicine ,Adult ,health-care ,esiintyvyys ,Central asia ,Population ,Nursing ,3121 Internal medicine ,03 medical and health sciences ,Medicine, General & Internal ,Drug Therapy ,General & Internal Medicine ,Life Science ,Humans ,ddc:610 ,education ,Antihypertensive Agents ,VLAG ,Aged ,Science & Technology ,Antihypertensive Agents/therapeutic use ,business.industry ,Omvårdnad ,fungi ,General and internal medicine ,Estados de Saúde e de Doença ,Taking medication ,Treatment ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Blood pressure ,Faculdade de Ciências Sociais ,3121 General medicine, internal medicine and other clinical medicine ,lääkehoito ,1182 Biochemistry, cell and molecular biology ,business ,Demography - Abstract
Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings: the number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings., British Heart Foundation Centre of Research Excellence Grant; World Health Organization (WHO); Abdul Latif Jameel Institute for Disease and Emergency Analytics Fellowship
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- 2021
49. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
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Iurilli, M.L.C. Zhou, B. Bennett, J.E. Carrillo-Larco, R.M. Sophiea, M.K. Rodriguez-Martinez, A. Bixby, H. Solomon, B.D. Taddei, C. Danaei, G. Di Cesare, M. Stevens, G.A. Riley, L.M. Savin, S. Cowan, M.J. Bovet, P. Damasceno, A. Chirita-Emandi, A. Hayes, A.J. Ikeda, N. Jackson, R.T. Khang, Y.-H. Laxmaiah, A. Liu, J. Miranda, J.J. Saidi, O. Sebert, S. Sorić, M. Starc, G. Gregg, E.W. Abarca-Gómez, L. Abdeen, Z.A. Abdrakhmanova, S. Ghaffar, S.A. Rahim, H.F.A. Abu-Rmeileh, N.M. Garba, J.A. Acosta-Cazares, B. Adams, R.J. Aekplakorn, W. Afsana, K. Afzal, S. Agdeppa, I.A. Aghazadeh-Attari, J. Aguilar-Salinas, C.A. Agyemang, C. Ahmad, M.H. Ahmad, N.A. Ahmadi, A. Ahmadi, N. Ahmed, S.H. Ahrens, W. Aitmurzaeva, G. Ajlouni, K. Al-Hazzaa, H.M. Al-Lahou, B. Al-Raddadi, R. Alarouj, M. AlBuhairan, F. AlDhukair, S. Ali, M.M. Alkandari, A. Alkerwi, A. Allin, K. Alvarez-Pedrerol, M. Aly, E. Amarapurkar, D.N. Amiri, P. Amougou, N. Amouyel, P. Andersen, L.B. Anderssen, S.A. Ängquist, L. Anjana, R.M. Ansari-Moghaddam, A. Aounallah-Skhiri, H. Araújo, J. Ariansen, I. Aris, T. Arku, R.E. Arlappa, N. Aryal, K.K. Aspelund, T. Assah, F.K. Assunção, M.C.F. Aung, M.S. Auvinen, J. Mária Avdicová Avi, S. Azevedo, A. Azimi-Nezhad, M. Azizi, F. Azmin, M. Babu, B.V. Bæksgaard Jørgensen, M. Baharudin, A. Bahijri, S. Baker, J.L. Balakrishna, N. Bamoshmoosh, M. Banach, M. Bandosz, P. Banegas, J.R. Baran, J. Barbagallo, C.M. Barceló, A. Barkat, A. Barros, A.J.D. Barros, M.V.G. Basit, A. Bastos, J.L.D. Bata, I. Batieha, A.M. Batista, R.L. Battakova, Z. Batyrbek, A. Baur, L.A. Beaglehole, R. Bel-Serrat, S. Belavendra, A. Romdhane, H.B. Benedics, J. Benet, M. Bergh, I.H. Berkinbayev, S. Bernabe-Ortiz, A. Bernotiene, G. Bettiol, H. Bezerra, J. Bhagyalaxmi, A. Bharadwaj, S. Bhargava, S.K. Bhutta, Z.A. Bi, H. Bi, Y. Bia, D. Lele, E.C.B. Bikbov, M.M. Bista, B. Bjelica, D.J. Bjerregaard, P. Bjertness, E. Bjertness, M.B. Björkelund, C. Bloch, K.V. Blokstra, A. Bo, S. Bobak, M. Boddy, L.M. Boehm, B.O. Boeing, H. Boggia, J.G. Bogova, E. Boissonnet, C.P. Bojesen, S.E. Bonaccio, M. Bongard, V. Bonilla-Vargas, A. Bopp, M. Borghs, H. Braeckevelt, L. Braeckman, L. Bragt, M.C.E. Brajkovich, I. Branca, F. Breckenkamp, J. Breda, J. Brenner, H. Brewster, L.M. Brian, G.R. Brinduse, L. Brophy, S. Bruno, G. Bueno-de-Mesquita, H.B. Bugge, A. Buoncristiano, M. Burazeri, G. Burns, C. de León, A.C. Cacciottolo, J. Cai, H. Cama, T. Cameron, C. Camolas, J. Can, G. Candido, A.P.C. Cañete, F. Capanzana, M.V. Capková, N. Capuano, E. Capuano, V. Cardol, M. Cardoso, V.C. Carlsson, A.C. Carmuega, E. Carvalho, J. Casajús, J.A. Casanueva, F.F. Celikcan, E. Censi, L. Cervantes-Loaiza, M. Cesar, J.A. Chamukuttan, S. Chan, A.W. Chan, Q. Chaturvedi, H.K. Chaturvedi, N. Rahim, N.C.A. Chee, M.L. Chen, C.-J. Chen, F. Chen, H. Chen, S. Chen, Z. Cheng, C.-Y. Cheraghian, B. Chetrit, A. Chikova-Iscener, E. Chiolero, A. Chiou, S.-T. Chirlaque, M.-D. Cho, B. Christensen, K. Christofaro, D.G. Chudek, J. Cifkova, R. Cilia, M. Cinteza, E. Claessens, F. Clarke, J. Clays, E. Cohen, E. Concin, H. Confortin, S.C. Cooper, C. Coppinger, T.C. Corpeleijn, E. Costanzo, S. Cottel, D. Cowell, C. Craig, C.L. Crampin, A.C. Crujeiras, A.B. Csilla, S. Cucu, A.M. Cui, L. Cureau, F.V. Czenczek-Lewandowska, E. D’Arrigo, G. d’Orsi, E. Dacica, L. Dal Re Saavedra, M.A. Dallongeville, J. Damsgaard, C.T. Dankner, R. Dantoft, T.M. Dasgupta, P. Dastgiri, S. Dauchet, L. Davletov, K. De Backer, G. De Bacquer, D. de Gaetano, G. De Henauw, S. de Oliveira, P.D. De Ridder, D. De Ridder, K. de Rooij, S.R. De Smedt, D. Deepa, M. Deev, A.D. DeGennaro, V., Jr Dehghan, A. Delisle, H. Delpeuch, F. Demarest, S. Dennison, E. Dereń, K. Deschamps, V. Dhimal, M. Di Castelnuovo, A.F. Dias-da-Costa, J.S. Díaz-Sánchez, M.E. Diaz, A. Dika, Z. Djalalinia, S. Djordjic, V. Do, H.T.P. Dobson, A.J. Donati, M.B. Donfrancesco, C. Donoso, S.P. Döring, A. Dorobantu, M. Dorosty, A.R. Doua, K. Dragano, N. Drygas, W. Duan, J.L. Duante, C.A. Duboz, P. Duda, R.B. Duleva, V. Dulskiene, V. Dumith, S.C. Dushpanova, A. Dzerve, V. Dziankowska-Zaborszczyk, E. Eddie, R. Eftekhar, E. Egbagbe, E.E. Eggertsen, R. Eghtesad, S. Eiben, G. Ekelund, U. El-Khateeb, M. Ati, J.E. Eldemire-Shearer, D. Eliasen, M. Elliott, P. Engle-Stone, R. Enguerran, M. Erasmus, R.T. Erbel, R. Erem, C. Eriksen, L. Eriksson, J.G. Escobedo-de la Peña, J. Eslami, S. Esmaeili, A. Evans, A. Faeh, D. Fakhretdinova, A.A. Fall, C.H. Faramarzi, E. Farjam, M. Sant’Angelo, V.F. Farzadfar, F. Fattahi, M.R. Fawwad, A. Felix-Redondo, F.J. Ferguson, T.S. Fernandes, R.A. Fernández-Bergés, D. Ferrante, D. Ferrao, T. Ferrari, M. Ferrario, M.M. Ferreccio, C. Ferrer, E. Ferrieres, J. Figueiró, T.H. Fijalkowska, A. Fink, G. Fischer, K. Foo, L.H. Forsner, M. Fouad, H.M. Francis, D.K. Maria do Carmo Franco Frikke-Schmidt, R. Frontera, G. Fuchs, F.D. Fuchs, S.C. Fujiati, I.I. Fujita, Y. Fumihiko, M. Furusawa, T. Gaciong, Z. Gafencu, M. Galbarczyk, A. Galenkamp, H. Galeone, D. Galfo, M. Galvano, F. Gao, J. Garcia-de-la-Hera, M. García-Solano, M. Gareta, D. Garnett, S.P. Gaspoz, J.-M. Gasull, M. Gaya, A.C.A. Gaya, A.R. Gazzinelli, A. Gehring, U. Geiger, H. Geleijnse, J.M. Ghanbari, A. Ghasemi, E. Gheorghe-Fronea, O.-F. Giampaoli, S. Gianfagna, F. Gill, T.K. Giovannelli, J. Gironella, G. Giwercman, A. Gkiouras, K. Godos, J. Gogen, S. Goldberg, M. Goldsmith, R.A. Goltzman, D. Gómez, S.F. Gomula, A. da Silva, B.G.C. Gonçalves, H. Gonzalez-Chica, D.A. Gonzalez-Gross, M. González-Leon, M. González-Rivas, J.P. González-Villalpando, C. González-Villalpando, M.-E. Gonzalez, A.R. Gottrand, F. Graça, A.P. Graff-Iversen, S. Grafnetter, D. Grajda, A. Grammatikopoulou, M.G. Gregor, R.D. Grodzicki, T. Grøholt, E.K. Grøntved, A. Grosso, G. Gruden, G. Gu, D. Gualdi-Russo, E. Guallar-Castillón, P. Gualtieri, A. Gudmundsson, E.F. Gudnason, V. Guerrero, R. Guessous, I. Guimaraes, A.L. Gulliford, M.C. Gunnlaugsdottir, J. Gunter, M.J. Guo, X.-H. Guo, Y. Gupta, P.C. Gupta, R. Gureje, O. Gurzkowska, B. Gutiérrez-González, E. Gutierrez, L. Gutzwiller, F. Ha, S. Hadaegh, F. Hadjigeorgiou, C.A. Haghshenas, R. Hakimi, H. Halkjær, J. Hambleton, I.R. Hamzeh, B. Hange, D. Hanif, A.A.M. Hantunen, S. Hao, J. Kumar, R.H. Hashemi-Shahri, S.M. Hassapidou, M. Hata, J. Haugsgjerd, T. He, J. He, Y. He, Y. Heidinger-Felso, R. Heinen, M. Hejgaard, T. Hendriks, M.E. dos Santos Henrique, R. Henriques, A. Cadena, L.H. Herrala, S. Herrera, V.M. Herter-Aeberli, I. Heshmat, R. Hill, A.G. Ho, S.Y. Ho, S.C. Hobbs, M. Holdsworth, M. Homayounfar, R. Homs, C. Hopman, W.M. Horimoto, A.R.V.R. Hormiga, C.M. Horta, B.L. Houti, L. Howitt, C. Htay, T.T. Htet, A.S. Htike, M.M.T. Hu, Y. Huerta, J.M. Huhtaniemi, I.T. Huiart, L. Petrescu, C.H. Huisman, M. Husseini, A. Huu, C.N. Huybrechts, I. Hwalla, N. Hyska, J. Iacoviello, L. Ibarluzea, J.M. Ibrahim, M.M. Wong, N.I. Ikram, M.A. Iotova, V. Irazola, V.E. Ishida, T. Islam, M. Islam, S.M.S. Iwasaki, M. Jacobs, J.M. Jaddou, H.Y. Jafar, T. James, K. Jamil, K.M. Jamrozik, K. Janszky, I. Janus, E. Jarani, J. Jarvelin, M.-R. Jasienska, G. Jelakovic, A. Jelakovic, B. Jennings, G. Jha, A.K. Jiang, C.Q. Jimenez, R.O. Jöckel, K.-H. Joffres, M. Johansson, M. Jokelainen, J.J. Jonas, J.B. Jonnagaddala, J. Jørgensen, T. Joshi, P. Joukar, F. Jovic, D.P. Jóźwiak, J.J. Juolevi, A. Jurak, G. Simina, I.J. Juresa, V. Kaaks, R. Kaducu, F.O. Kafatos, A. Kajantie, E.O. Kalmatayeva, Z. Kalter-Leibovici, O. Kameli, Y. Kampmann, F.B. Kanala, K.R. Kannan, S. Kapantais, E. Karakosta, A. Kårhus, L.L. Karki, K.B. Katibeh, M. Katz, J. Katzmarzyk, P.T. Kauhanen, J. Kaur, P. Kavousi, M. Kazakbaeva, G.M. Keil, U. Boker, L.K. Keinänen-Kiukaanniemi, S. Kelishadi, R. Kelleher, C. Kemper, H.C.G. Kengne, A.P. Keramati, M. Kerimkulova, A. Kersting, M. Key, T. Khader, Y.S. Khalili, D. Khaw, K.-T. Kheiri, B. Kheradmand, M. Khosravi, A. Khouw, I.M.S.L. Kiechl-Kohlendorfer, U. Kiechl, S. Killewo, J. Kim, D.W. Kim, H.C. Kim, J. Kindblom, J.M. Klakk, H. Klimek, M. Klimont, J. Klumbiene, J. Knoflach, M. Koirala, B. Kolle, E. Kolsteren, P. König, J. Korpelainen, R. Korrovits, P. Korzycka, M. Kos, J. Koskinen, S. Kouda, K. Kovacs, V.A. Kowlessur, S. Koziel, S. Kratenova, J. Kratzer, W. Kriemler, S. Kristensen, P.L. Krokstad, S. Kromhout, D. Kruger, H.S. Kubinova, R. Kuciene, R. Kujala, U.M. Kujundzic, E. Kulaga, Z. Kumar, R.K. Kunešová, M. Kurjata, P. Kusuma, Y.S. Kuulasmaa, K. Kyobutungi, C. La, Q.N. Laamiri, F.Z. Laatikainen, T. Lachat, C. Laid, Y. Lam, T.H. Lambrinou, C.-P. Landais, E. Lanska, V. Lappas, G. Larijani, B. Latt, T.S. Lauria, L. Lazo-Porras, M. Le Coroller, G. Bao, K.L.N. Le Port, A. Le, T.D. Lee, J. Lee, J. Lee, P.H. Lehmann, N. Lehtimäki, T. Lemogoum, D. Levitt, N.S. Li, Y. Liivak, M. Lilly, C.L. Lim, W.-Y. Lima-Costa, M.F. Lin, H.-H. Lin, X. Lin, Y.-T. Lind, L. Linneberg, A. Lissner, L. Litwin, M. Liu, L. Lo, W.-C. Loit, H.-M. Long, K.Q. Lopes, L. Lopes, O. Lopez-Garcia, E. Lopez, T. Lotufo, P.A. Lozano, J.E. Lukrafka, J.L. Luksiene, D. Lundqvist, A. Lundqvist, R. Lunet, N. Lunogelo, C. Lustigová, M. Łuszczki, E. Ma, G. Ma, J. Ma, X. Machado-Coelho, G.L.L. Machado-Rodrigues, A.M. Macieira, L.M. Madar, A.A. Maggi, S. Magliano, D.J. Magnacca, S. Magriplis, E. Mahasampath, G. Maire, B. Majer, M. Makdisse, M. Mäki, P. Malekzadeh, F. Malekzadeh, R. Malhotra, R. Rao, K.M. Malyutina, S.K. Maniego, L.V. Manios, Y. Mann, J.I. Mansour-Ghanaei, F. Manzato, E. Margozzini, P. Markaki, A. Markey, O. Ioannidou, E.M. Marques-Vidal, P. Marques, L.P. Marrugat, J. Martin-Prevel, Y. Martin, R. Martorell, R. Martos, E. Maruszczak, K. Marventano, S. Mascarenhas, L.P. Masoodi, S.R. Mathiesen, E.B. Mathur, P. Matijasevich, A. Matsha, T.E. Mavrogianni, C. Mazur, A. Mbanya, J.C.N. McFarlane, S.R. McGarvey, S.T. McKee, M. McLachlan, S. McLean, R.M. McLean, S.B. McNulty, B.A. Benchekor, S.M. Medzioniene, J. Mehdipour, P. Mehlig, K. Mehrparvar, A.H. Meirhaeghe, A. Meisfjord, J. Meisinger, C. Menezes, A.M.B. Menon, G.R. Mensink, G.B.M. Menzano, M.T. Mereke, A. Meshram, I.I. Metspalu, A. Meyer, H.E. Mi, J. Michaelsen, K.F. Michels, N. Mikkel, K. Milkowska, K. Miller, J.C. Minderico, C.S. Mini, G.K. Miquel, J.F. Mirjalili, M.R. Mirkopoulou, D. Mirrakhimov, E. Mišigoj-Durakovic, M. Mistretta, A. Mocanu, V. Modesti, P.A. Moghaddam, S.S. Mohajer, B. Mohamed, M.K. Mohamed, S.F. Mohammad, K. Mohammadi, Z. Mohammadifard, N. Mohammadpourhodki, R. Mohan, V. Mohanna, S. Yusoff, M.F.M. Mohebbi, I. Mohebi, F. Moitry, M. Molbo, D. Møllehave, L.T. Møller, N.C. Molnár, D. Momenan, A. Mondo, C.K. Monroy-Valle, M. Monterrubio-Flores, E. Monyeki, K.D.K. Moon, J.S. Moosazadeh, M. Moreira, L.B. Morejon, A. Moreno, L.A. Morgan, K. Morin, S.N. Mortensen, E.L. Moschonis, G. Mossakowska, M. Mostafa, A. Mota-Pinto, A. Mota, J. Motlagh, M.E. Motta, J. Moura-dos-Santos, M.A. Mridha, M.K. Msyamboza, K.P. Mu, T.T. Muc, M. Mugoša, B. Muiesan, M.L. Mukhtorova, P. Müller-Nurasyid, M. Murphy, N. Mursu, J. Murtagh, E.M. Musa, K.I. Milanovic, S.M. Musil, V. Mustafa, N. Nabipour, I. Naderimagham, S. Nagel, G. Naidu, B.M. Najafi, F. Nakamura, H. Námešná, J. Nang, E.E.K. Nangia, V.B. Nankap, M. Narake, S. Nardone, P. Nauck, M. Neal, W.A. Nejatizadeh, A. Nekkantti, C. Nelis, K. Nelis, L. Nenko, I. Neovius, M. Nervi, F. Nguyen, C.T. Nguyen, N.D. Nguyen, Q.N. Nieto-Martínez, R.E. Nikitin, Y.P. Ning, G. Ninomiya, T. Nishtar, S. Noale, M. Noboa, O.A. Nogueira, H. Norat, T. Nordendahl, M. Nordestgaard, B.G. Noto, D. Nowak-Szczepanska, N. Al Nsour, M. Nuhoglu, I. Nurk, E. O’Neill, T.W. O’Reilly, D. Obreja, G. Ochimana, C. Ochoa-Avilés, A.M. Oda, E. Oh, K. Ohara, K. Ohlsson, C. Ohtsuka, R. Olafsson, O. Olinto, M.T.A. Oliveira, I.O. Omar, M.A. Onat, A. Ong, S.K. Ono, L.M. Ordunez, P. Ornelas, R. Ortiz, A.P. Ortiz, P.J. Osler, M. Osmond, C. Ostojic, S.M. Ostovar, A. Otero, J.A. Overvad, K. Owusu-Dabo, E. Paccaud, F.M. Padez, C. Pagkalos, I. Pahomova, E. de Paiva, K.M. Pajak, A. Palli, D. Palloni, A. Palmieri, L. Pan, W.-H. Panda-Jonas, S. Pandey, A. Panza, F. Papandreou, D. Park, S.-W. Park, S. Parnell, W.R. Parsaeian, M. Pascanu, I.M. Pasquet, P. Patel, N.D. Pecin, I. Pednekar, M.S. Peer, N. Pei, G. Peixoto, S.V. Peltonen, M. Pereira, A.C. Peres, M.A. Pérez-Farinós, N. Pérez, C.M. Peterkova, V. Peters, A. Petersmann, A. Petkeviciene, J. Petrauskiene, A. Pettenuzzo, E. Peykari, N. Pham, S.T. Pichardo, R.N. Pierannunzio, D. Pigeot, I. Pikhart, H. Pilav, A. Pilotto, L. Pistelli, F. Pitakaka, F. Piwonska, A. Pizarro, A.N. Plans-Rubió, P. Poh, B.K. Pohlabeln, H. Pop, R.M. Popovic, S.R. Porta, M. Posch, G. Poudyal, A. Poulimeneas, D. Pouraram, H. Pourfarzi, F. Pourshams, A. Poustchi, H. Pradeepa, R. Price, A.J. Price, J.F. Providencia, R. Puder, J.J. Pudule, I. Puhakka, S.E. Puiu, M. Punab, M. Qasrawi, R.F. Qorbani, M. Bao, T.Q. Radic, I. Radisauskas, R. Rahimikazerooni, S. Rahman, M. Rahman, M. Raitakari, O. Raj, M. Rakhimova, E. Rakhmatulloev, S. Rakovac, I. Rao, S.R. Ramachandran, A. Ramke, J. Ramos, E. Ramos, R. Rampal, L. Rampal, S. Rarra, V. Rascon-Pacheco, R.A. Rasmussen, M. Rech, C.R. Redon, J. Reganit, P.F.M. Regecová, V. Revilla, L. Rezaianzadeh, A. Ribas-Barba, L. Ribeiro, R. Riboli, E. Richter, A. Rigo, F. Rinaldo, N. de Wit, T.F.R. Rito, A. Ritti-Dias, R.M. Rivera, J.A. Robitaille, C. Roccaldo, R. Rodrigues, D. Rodríguez-Artalejo, F. del Cristo Rodriguez-Perez, M. Rodríguez-Villamizar, L.A. Roggenbuck, U. Rojas-Martinez, R. Rojroongwasinkul, N. Romaguera, D. Romeo, E.L. Rosario, R.V. Rosengren, A. Rouse, I. Roy, J.G.R. Rubinstein, A. Rühli, F.J. Ruidavets, J.-B. Ruiz-Betancourt, B.S. Ruiz-Castell, M. Moreno, E.R. Rusakova, I.A. Jonsson, K.R. Russo, P. Rust, P. Rutkowski, M. Sabanayagam, C. Sacchini, E. Sachdev, H.S. Sadjadi, A. Safarpour, A.R. Safiri, S. Saki, N. Salanave, B. Martinez, E.S. Salmerón, D. Salomaa, V. Salonen, J.T. Salvetti, M. Samoutian, M. Sánchez-Abanto, J. Sans, S. Marina, L.S. Santos, D.A. Santos, I.S. Santos, L.C. Santos, M.P. Santos, O. Santos, R. Sanz, S.S. Saramies, J.L. Sardinha, L.B. Sarrafzadegan, N. Sathish, T. Saum, K.-U. Savva, S. Savy, M. Sawada, N. Sbaraini, M. Scazufca, M. Schaan, B.D. Rosario, A.S. Schargrodsky, H. Schienkiewitz, A. Schipf, S. Schmidt, C.O. Schmidt, I.M. Schnohr, P. Schöttker, B. Schramm, S. Schramm, S. Schröder, H. Schultsz, C. Schutte, A.E. Sein, A.A. Selamat, R. Sember, V. Sen, A. Senbanjo, I.O. Sepanlou, S.G. Sequera, V. Serra-Majem, L. Servais, J. Ševcíková, L. Shalnova, S.A. Shamah-Levy, T. Shamshirgaran, M. Shanthirani, C.S. Sharafkhah, M. Sharma, S.K. Shaw, J.E. Shayanrad, A. Shayesteh, A.A. Shengelia, L. Shi, Z. Shibuya, K. Shimizu-Furusawa, H. Shin, D.W. Shirani, M. Shiri, R. Shrestha, N. Si-Ramlee, K. Siani, A. Siantar, R. Sibai, A.M. Silva, A.M. Silva, D.A.S. Simon, M. Simons, J. Simons, L.A. Sjöberg, A. Sjöström, M. Skodje, G. Slowikowska-Hilczer, J. Slusarczyk, P. Smeeth, L. So, H.-K. Soares, F.C. Sobek, G. Sobngwi, E. Sodemann, M. Söderberg, S. Soekatri, M.Y.E. Soemantri, A. Sofat, R. Solfrizzi, V. Somi, M.H. Sonestedt, E. Song, Y. Sørensen, T.I.A. Sørgjerd, E.P. Jérome, C.S. Soto-Rojas, V.E. Soumaré, A. Sovic, S. Sparboe-Nilsen, B. Sparrenberger, K. Spinelli, A. Spiroski, I. Staessen, J.A. Stamm, H. Stathopoulou, M.G. Staub, K. Stavreski, B. Steene-Johannessen, J. Stehle, P. Stein, A.D. Stergiou, G.S. Stessman, J. Stevanovic, R. Stieber, J. Stöckl, D. Stocks, T. Stokwiszewski, J. Stoyanova, E. Stratton, G. Stronks, K. Strufaldi, M.W. Sturua, L. Suárez-Medina, S. Suka, M. Sun, C.-A. Sundström, J. Sung, Y.-T. Sunyer, J. Suriyawongpaisal, P. Swinburn, B.A. Sy, R.G. Syddall, H.E. Sylva, R.C. Szklo, M. Szponar, L. Tai, E.S. Tammesoo, M.-L. Tamosiunas, A. Tan, E.J. Tang, X. Tanrygulyyeva, M. Tanser, F. Tao, Y. Tarawneh, M.R. Tarp, J. Tarqui-Mamani, C.B. Braunerová, R.T. Taylor, A. Taylor, J. Tchibindat, F. Tebar, W.R. Tell, G.S. Tello, T. Tham, Y.C. Thankappan, K.R. Theobald, H. Theodoridis, X. Thijs, L. Thomas, N. Thuesen, B.H. Tichá, L. Timmermans, E.J. Tjonneland, A. Tolonen, H.K. Tolstrup, J.S. Topbas, M. Topór-Madry, R. Torheim, L.E. Tormo, M.J. Tornaritis, M.J. Torrent, M. Torres-Collado, L. Toselli, S. Touloumi, G. Traissac, P. Tran, T.T.-H. Trichopoulos, D. Trichopoulou, A. Trinh, D.T.H. Trivedi, A. Tshepo, L. Tsigga, M. Tsugane, S. Tuliakova, A.M. Tulloch-Reid, M.K. Tullu, F. Tuomainen, T.-P. Tuomilehto, J. Turley, M.L. Twig, G. Tynelius, P. Tzotzas, T. Tzourio, C. Ueda, P. Ugel, E. Ukoli, F.A.M. Ulmer, H. Unal, B. Usupova, Z. Uusitalo, H.M.T. Uysal, N. Vaitkeviciute, J. Valdivia, G. Vale, S. Valvi, D. van Dam, R.M. Van der Heyden, J. van der Schouw, Y.T. Van Herck, K. Van Minh, H. Van Schoor, N.M. van Valkengoed, I.G.M. Vanderschueren, D. Vanuzzo, D. Varbo, A. Varela-Moreiras, G. Varona-Pérez, P. Vasan, S.K. Vega, T. Veidebaum, T. Velasquez-Melendez, G. Velika, B. Veronesi, G. Verschuren, W.M.M. Victora, C.G. Viegi, G. Viet, L. Villalpando, S. Vineis, P. Vioque, J. Virtanen, J.K. Visser, M. Visvikis-Siest, S. Viswanathan, B. Vladulescu, M. Vlasoff, T. Vocanec, D. Vollenweider, P. Völzke, H. Voutilainen, A. Voutilainen, S. Vrijheid, M. Vrijkotte, T.G.M. Wade, A.N. Wagner, A. Waldhör, T. Walton, J. Wambiya, E.O.A. Bebakar, A.M.W. Mohamud, W.N.W. de Souza Wanderley Júnior, R. Wang, M.-D. Wang, N. Wang, Q. Wang, X. Wang, Y.X. Wang, Y.-W. Wannamethee, S.G. Wareham, N. Weber, A. Wedderkopp, N. Weerasekera, D. Weghuber, D. Wei, W. Weres, A. Werner, B. Whincup, P.H. Widhalm, K. Widyahening, I.S. Wiecek, A. Wilks, R.J. Willeit, J. Willeit, P. Williams, J. Wilsgaard, T. Wojtyniak, B. Wong-McClure, R.A. Wong, A. Wong, J.E. Wong, T.Y. Woo, J. Woodward, M. Wu, F.C. Wu, J. Wu, L.J. Wu, S. Xu, H. Xu, L. Yaacob, N.A. Yamborisut, U. Yan, W. Yang, L. Yang, X. Yang, Y. Yardim, N. Yaseri, M. Yasuharu, T. Ye, X. Yiallouros, P.K. Yoosefi, M. Yoshihara, A. You, Q.S. You, S.-L. Younger-Coleman, N.O. Yusof, S.M. Yusoff, A.F. Zaccagni, L. Zafiropulos, V. Zainuddin, A.A. Zakavi, S.R. Zamani, F. Zambon, S. Zampelas, A. Zamrazilová, H. Zapata, M.E. Zargar, A.H. Zaw, K.K. Zdrojewski, T. Zejglicova, K. Vrkic, T.Z. Zeng, Y. Zhang, L. Zhang, Z.-Y. Zhao, D. Zhao, M.-H. Zhao, W. Zhen, S. Zheng, W. Zheng, Y. Zholdin, B. Zhou, M. Zhu, D. Zins, M. Zitt, E. Zocalo, Y. Cisneros, J.Z. Zuziak, M. Ezzati, M. Filippi, S. NCD Risk Factor Collaboration (NCD-RisC)
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nutritional and metabolic diseases ,sense organs ,skin and connective tissue diseases - Abstract
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. © Copyright.
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- 2021
50. Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial
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Garach AM, Cornejo-Pareja I, Martínez-González MÁ, Bulló M, Corella D, Castañer O, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Bernal-López MR, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, Prieto L, Ros E, Fernández-Aranda F, Camacho-Barcia L, Ortega-Azorin C, Soria M, Fiol M, Compañ-Gabucio L, Goicolea-Güemez L, Pérez-López J, Goñi N, Pérez-Cabrera J, Sacanella E, Fernández-García JC, Miró-Moriano L, Gimenez-Gracia M, Razquin C, Paz-Graniel I, Guillem P, Zomeño MD, Moñino M, Oncina-Canovas A, Salaverria-Lete I, Toledo E, Salas-Salvadó J, Schröder H, Tinahones FJ, and Predimed-Plus Investigators
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cognition ,milk ,consumption ,dairy products ,cognitive decline - Abstract
Scope To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk. Methods and results Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE). A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 +/- 12.21 g, while patients with better MMSE score (27-30) consumed a mean of 341.23 +/- 2.73 g (p < 0.05). Those subjects with the lower milk consumption (
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- 2021
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