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Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose rates, short duration and broad energy spectrum. Typical temporal modality of laser-driven irradiation, the so-called fast-fractionation, results from the composition of multiple, temporally separated, ultra-short dose fractions. In this paper we present the use of a high-energy laser system for delivering the target dose in a single nanosecond pulse, for ultra-fast irradiation of biological samples. A transport line composed by two permanent magnet quadrupoles and a scattering system is used to improve the dose profile and to control the delivered dose-per-pulse. A single-shot dosimetry protocol for the broad-spectrum proton source using Monte Carlo simulations was developed. Doses as high as 20Gy could be delivered in a single shot, lasting less than 10ns over a 1.0cm diameter sample holder, at a dose-rate exceeding 10^9 Gy/s. Exploratory application of extreme laser-driven irradiation conditions, falling within the FLASH irradiation protocol, are presented for in vitro and in vivo irradiation. A reduction of radiation-induced oxidative stress in-vitro and radiation-induced developmental damage in vivo were observed, whereas anti-tumoral efficacy was confirmed by cell survival assay., Comment: 13 pages, 15 figures

We report on the first experimental characterisation of a gamma-ray spectrometer designed to spectrally resolve high-flux photon beams with energies in the GeV range. The spectrometer has been experimentally characterised using a bremsstrahlung source obtained at the Apollon laser facility during the interaction of laser-wakefield accelerated electron beams (maximum energy of 1.7 GeV and overall charge of 207$\pm$62 pC) with a 1 mm thick tantalum target. Experimental data confirms the possibility of performing single-shot measurements, without the need for accumulation, with a high signal to noise ratio. Scaling the results to photons in the multi-GeV range suggests the possibility of achieving percent-level energy resolution, as required, for instance, by the next generation of experiments in strong-field quantum electrodynamics., Comment: 20 pages, 7 figures; changes - expanded explanations, results and conclusions unchanged

The generation of thin and high density plasma slabs at high repetition rate is a key issue for ultra-high intensity laser applications. We present a scheme to create such plasma slabs, based on the propagation and collision in a gas jet of two counter-propagating blast waves (BW). Each BW is launched by a sudden and local heating induced by a nanosecond laser beam that propagates along the side of the jet. The resulting cylindrical BW expands perpendicular to the beam. The shock front, bent by the gas jet density gradient, pushes and compresses the plasma toward the jet center. By using two parallel ns laser beams, this scheme enables to tailor independently two opposite sides of the jet, while avoiding the damage risks associated with counterpropagating laser beams. A parametric study is performed using two and three dimensional hydrodynamic, as well as kinetic simulations. The BWs bending combined with the collision in a stagnation regime increases the density by more than 10 times and generates a very thin (down to few microns), near to over-critical plasma slab with a high density contrast (> 100), and a lifetime of a few hundred picoseconds. Two dimensional particle-in-cell simulations are used to study the influence of plasma tailoring on proton acceleration by a high-intensity sub-picosecond laser pulse. Tailoring the plasma not only at the entrance but also the exit side of the ps-pulse enhances the proton beam collimation, increases significantly the number of high energy protons, as well as their maximum energy.

The Time-of-Flight (ToF) technique coupled with semiconductor-like detectors, as silicon carbide and diamond, is one of the most promising diagnostic methods for high-energy, high repetition rate, laser-accelerated ions allowing a full on-line beam spectral characterization. A new analysis method for reconstructing the energy spectrum of high-energy laser-driven ion beams from TOF signals is hereby presented and discussed. The proposed method takes into account the detector's working principle, through the accurate calculation of the energy loss in the detector active layer, using Monte Carlo simulations. The analysis method was validated against well-established diagnostics, such as the Thomson Parabola Spectrometer, during an experimental campaign carried out at the Rutherford Appleton Laboratory (RAL, UK) with the high-energy laser-driven protons accelerated by the VULCAN Petawatt laser.

The expansion of a thermal pressure-driven radial blast shell into a dilute ambient plasma is examined with two-dimensional PIC simulations. The purpose is to determine if laminar shocks form in a collisionless plasma that resemble their magnetohydrodynamic counterparts. The ambient plasma is composed of electrons with the temperature 2 keV and cool fully ionized nitrogen ions. It is permeated by a spatially uniform magnetic field. A forward shock forms between the shocked ambient medium and the pristine ambient medium, which changes from an ion acoustic one through a slow magnetosonic one to a fast magnetosonic shock with increasing shock propagation angles relative to the magnetic field. The slow magnetosonic shock that propagates obliquely to the magnetic field changes into a tangential discontinuity for a perpendicular propagation direction, which is in line with the magnetohydrodynamic model. The expulsion of the magnetic field by the expanding blast shell triggers an electron-cyclotron drift instability., Comment: 10 pages and 11 figures. Accepted for publication in the Physics of Plasmas

The experimental study of the dynamics of neutral electron-positron beams is an emerging area of research, enabled by the recent results on the generation of this exotic state of matter in the laboratory. Electron-positron beams and plasmas are believed to play a major role in the dynamics of extreme astrophysical objects such as supermassive black holes and pulsars. For instance, they are believed to be the main constituents of a large number of astrophysical jets, and they have been proposed to significantly contribute to the emission of gamma-ray bursts and their afterglow. However, despite extensive numerical modelling and indirect astrophysical observations, a detailed experimental characterisation of the dynamics of these objects is still at its infancy. Here, we will report on some of the general features of experiments studying the dynamics of electron-positron beams in a fully laser-driven setup.

The expansion of a dense plasma into a dilute plasma across an initially uniform perpendicular magnetic field is followed with a one-dimensional particle-in-cell (PIC) simulation over MHD time scales. The dense plasma expands in the form of a fast rarefaction wave. The accelerated dilute plasma becomes separated from the dense plasma by a tangential discontinuity at its back. A fast magnetosonic shock with the Mach number 1.5 forms at its front. Our simulation demonstrates how wave dispersion widens the shock transition layer into a train of nonlinear fast magnetosonic waves., Comment: 5 pages, 4 figures, accepted for publication in Physics of Plasmas

The expansion of a radial blast shell into an ambient plasma is modeled with a particle-in-cell (PIC) simulation. The unmagnetized plasma consists of electrons and protons. The formation and evolution of an electrostatic shock is observed, which is trailed by ion-acoustic solitary waves that grow on the beam of the blast shell ions in the post-shock plasma. In spite of the initially radially symmetric outflow, the solitary waves become twisted and entangled and, hence, they break the radial symmetry of the flow. The waves and their interaction with the shocked ambient ions slows down the blast shell protons and brings the post-shock plasma closer to an equilibrium., Comment: 5 pages, 4 figures, accepted by Physics of Plasmas

A new type of proton acceleration stemming from large-scale gradients, low-density targets, irradiated by an intense near-infrared laser is observed. The produced protons are characterized by high-energies (with a broad spectrum), are emitted in a very directional manner, and the process is associated to relaxed laser (no need for high-contrast) and target (no need for ultra-thin or expensive targets) constraints. As such, this process appears quite effective compared to the standard and commonly used Target Normal Sheath Acceleration technique (TNSA), or more exploratory mechanisms like Radiation Pressure Acceleration (RPA). The data are underpinned by 3D numerical simulations which suggest that in these conditions Low Density Collisionless Shock Acceleration (LDCSA) is at play, which combines an initial Collisionless Shock Acceleration (CSA) to a boost procured by a TNSA-like sheath field in the downward density ramp of the target, which leads to an overall broad spectrum. Experiments performed at 10^20 W/cm^2 laser intensity show that LDCSA can accelerate, from ~1% critical density, mm-scale targets, up to 5x10^9 protons/MeV/sr/J with energies up to 45(+/- 5) MeV in a collimated (~6$^\circ$ half-angle) manner.

We report on the first experimental observation of a current-driven instability developing in a quasi-neutral matter-antimatter beam. Strong magnetic fields ($\geq$ 1 T) are measured, via means of a proton radiography technique, after the propagation of a neutral electron-positron beam through a background electron-ion plasma.The experimentally determined equipartition parameter of $\epsilon_B \approx 10^{-3}$, is typical of values inferred from models of astrophysical gamma-ray bursts, in which the relativistic flows are also expected to be pair dominated. The data, supported by Particle-In-Cell simulations and simple analytical estimates, indicate that these magnetic fields persist in the background plasma for thousands of inverse plasma frequencies. The existence of such long-lived magnetic fields can be related to analog astrophysical systems, such as those prevalent in lepton-dominated jets.

Direct investigation of ion-induced dynamics in matter on picosecond (ps, 10-12 s) timescales has been precluded to date by the relatively long nanosecond (ns, 10-9 s) scale ion pulses typically provided by radiofrequency accelerators1. By contrast, laser-driven ion accelerators provide bursts of ps duration2, but have yet to be applied to the study of ultrafast ion-induced transients in matter. We report on the evolution of an electron-hole plasma excited in borosilicate glass by such bursts. This is observed as an onset of opacity to synchronised optical probe radiation and is characterised by the 3.0 +/- 0.8 ps ion pump rise-time . The observed decay-time of 35 +/- 3 ps i.e. is in excellent agreement with modelling and reveals the rapidly evolving electron temperature (>10 3 K) and carrier number density (>10 17cm-3). This result demonstrates that ps laser accelerated ion bursts are directly applicable to investigating the ultrafast response of matter to ion interactions and, in particular, to ultrafast pulsed ion radiolysis of water3-5, the radiolytic decompositions of which underpin biological cell damage and hadrontherapy for cancer treatment6., Comment: 11 pages

Nonrelativistic electrostatic unmagnetized shocks are frequently observed in laboratory plasmas and they are likely to exist in astrophysical plasmas. Their maximum speed, expressed in units of the ion acoustic speed far upstream of the shock, depends only on the electron-to-ion temperature ratio if binary collisions are absent. The formation and evolution of such shocks is examined here for a wide range of shock speeds with particle-in-cell (PIC) simulations. The initial temperatures of the electrons and the 400 times heavier ions are equal. Shocks form on electron time scales at Mach numbers between 1.7 and 2.2. Shocks with Mach numbers up to 2.5 form after tens of inverse ion plasma frequencies. The density of the shock-reflected ion beam increases and the number of ions crossing the shock thus decreases with an increasing Mach number, causing a slower expansion of the downstream region in its rest frame. The interval occupied by this ion beam is on a positive potential relative to the far upstream. This potential pre-heats the electrons ahead of the shock even in the absence of beam instabilities and decouples the electron temperature in the foreshock ahead of the shock from the one in the far upstream plasma. The effective Mach number of the shock is reduced by this electron heating. This effect can potentially stabilize nonrelativistic electrostatic shocks moving as fast as supernova remnant (SNR) shocks., Comment: 11 pages, 12 figures, accepted for publication in Physics of Plasmas

We report on the temporally and spatially resolved detection of the precursory stages that lead to the formation of an unmagnetized, supercritical collision-less shock in a laser-driven laboratory experiment. The measured evolution of the electrostatic potential associated with the shock unveils the transition from a current free double layer into a symmetric shock structure, stabilized by ion reflection at the shock front. Supported by a matching Particle-In-Cell simulation and theoretical considerations, we suggest that this process is analogeous to ion reflection at supercritical collisionless shocks in supernova remnants., Comment: 5 pages, 4 figures, accepted for publication in Physical Review Letters

The dynamics of magnetic fields with amplitude of several tens of Megagauss, generated at both sides of a solid target irradiated with a high intensity (? 1019W/cm2) picosecond laser pulse, has been spatially and temporally resolved using a proton imaging technique. The amplitude of the magnetic fields is sufficiently large to have a constraining effect on the radial expansion of the plasma sheath at the target surfaces. These results, supported by numerical simulations and simple analytical modeling, may have implications for ion acceleration driven by the plasma sheath at the rear side of the target as well as for the laboratory study of self-collimated high-energy plasma jets., Comment: Accepted for publication in Physical Review Letters

The expansion of an initially unmagnetized planar rarefaction wave has recently been shown to trigger a thermal anisotropy-driven Weibel instability (TAWI), which can generate magnetic fields from noise levels. It is examined here if the TAWI can also grow in a curved rarefaction wave. The expansion of an initially unmagnetized circular plasma cloud, which consists of protons and hot electrons, into a vacuum is modelled for this purpose with a two-dimensional particle-in-cell (PIC) simulation. It is shown that the momentum transfer from the electrons to the radially accelerating protons can indeed trigger a TAWI. Radial current channels form and the aperiodic growth of a magnetowave is observed, which has a magnetic field that is oriented orthogonal to the simulation plane. The induced electric field implies that the electron density gradient is no longer parallel to the electric field. Evidence is presented here for that this electric field modification triggers a second magnetic instability, which results in a rotational low-frequency magnetowave. The relevance of the TAWI is discussed for the growth of small-scale magnetic fields in astrophysical environments, which are needed to explain the electromagnetic emissions by astrophysical jets. It is outlined how this instability could be examined experimentally.

Electrostatic (E) fields associated with the interaction of a well-controlled, high-power, nanosecond laser pulse with an underdense plasma are diagnosed by proton radiography. Using a current 3D wave propagation code equipped with nonlinear and nonlocal hydrodynamics, we can model the measured E-fields that are driven by the laser ponderomotive force in the region where the laser undergoes filamentation. However, strong fields of up to 110 MV/m measured in the first millimeter of propagation cannot be reproduced in the simulations. This could point to the presence of unexpected strong thermal electron pressure gradients possibly linked to ion acoustic turbulence, thus emphasizing the need for the development of full kinetic collisional simulations in order to properly model laser-plasma interaction in these strongly nonlinear conditions., Comment: 12 pages, 4 figures, submitted to Physics of Plasmas

The localized deposition of the energy of a laser pulse, as it ablates a solid target, introduces high thermal pressure gradients in the plasma. The thermal expansion of this laser-heated plasma into the ambient medium (ionized residual gas) triggers the formation of non-linear structures in the collision-less plasma. Here an electron-proton plasma is modelled with a particle-in-cell (PIC) simulation to reproduce aspects of this plasma expansion. A jump is introduced in the thermal pressure of the plasma, across which the otherwise spatially uniform temperature and density change by the factor 100. The electrons from the hot plasma expand into the cool one and the charge imbalance drags a beam of cool electrons into the hot plasma. This double layer reduces the electron temperature gradient. The presence of the low-pressure plasma modifies the proton dynamics compared to the plasma expansion into a vacuum. The jump in the thermal pressure develops into a primary shock. The fast protons, which move from the hot into the cold plasma in form of a beam, give rise to the formation of phase space holes in the electron and proton distributions. The proton phase space holes develop into a secondary shock that thermalizes the beam., Comment: 17 pages, 9 Figures, accepted for publication in plasma physics and controlled fusion

In recent experiments of laser pulse interaction at relativistic intensities with a low density plasma, the proton radiography technique showed evidence of long--lived field structures generated after the self-channeling of the laser pulse. We present 2D particle-in-cell simulations of this interaction regime, where the dynamics of similar structures has been resolved with high temporal and spatial resolution. An axially symmetrical field pattern, resembling both soliton-like and vortex structures, has been observed. A study of the physics of such structures and a comparison with experimental data is in progress., Comment: To appear in the Proceedings of the International Workshop "Collective phenomena in macroscopic systems", Villa Olmo, Como, Italy, December 4-6, 2006; 9 pages, 8 figures submitted in GIF format

The dynamics of transient electric fields generated by the interaction of high intensity laser pulses with underdense plasmas has been studied experimentally with the proton projection imaging technique. The formation of a charged channel, the propagation of its front edge and the late electric field evolution have been characterised with high temporal and spatial resolution. Particle-in-cell simulations and an electrostatic, ponderomotive model reproduce the experimental features and trace them back to the ponderomotive expulsion of electrons and the subsequent ion acceleration., Comment: 5 figures, accepted for publication in New Journal of Physics