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372 results on '"Roma, Guglielmo"'

2. The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice

Author

Tuominen, Iina, Fuqua, Brie K, Pan, Calvin, Renaud, Nicole, Wroblewski, Kevin, Civelek, Mete, Clerkin, Kara, Asaryan, Ashot, Haroutunian, Sara G, Loureiro, Joseph, Borawski, Jason, Roma, Guglielmo, Knehr, Judith, Carbone, Walter, French, Samuel, Parks, Brian W, Hui, Simon T, Mehrabian, Margarete, Magyar, Clara, Cantor, Rita M, Ukomadu, Chinweike, Lusis, Aldons J, and Beaven, Simon W

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Digestive Diseases, Chronic Liver Disease and Cirrhosis, Liver Disease, Biotechnology, Human Genome, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Animals, Carbon Tetrachloride, Disease Models, Animal, Gene Regulatory Networks, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Injections, Intraperitoneal, Liver, Liver Cirrhosis, Male, Mice, Quantitative Trait Loci, CCl4, Systems Genetics, Liver Toxicity and Injury, CCl(4), Biochemistry and cell biology, Clinical sciences
Abstract

Background & aimsLiver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl4)-induced liver fibrosis using the Hybrid Mouse Diversity Panel, a panel of more than 100 genetically distinct mouse strains optimized for genome-wide association studies and systems genetics.MethodsChronic liver injury was induced by CCl4 injections twice weekly for 6 weeks. Four hundred thirty-seven mice received CCl4 and 256 received vehicle, after which animals were euthanized for liver histology and gene expression. Using automated digital image analysis, we quantified fibrosis as the collagen proportionate area of the whole section, excluding normal collagen.ResultsWe discovered broad variation in fibrosis among the Hybrid Mouse Diversity Panel strains, demonstrating a significant genetic influence. Genome-wide association analyses revealed significant and suggestive loci underlying susceptibility to fibrosis, some of which overlapped with loci identified in mouse crosses and human population studies. Liver global gene expression was assessed by RNA sequencing across the strains, and candidate genes were identified using differential expression and expression quantitative trait locus analyses. Gene set enrichment analyses identified the underlying pathways, of which stellate cell involvement was prominent, and coexpression network modeling identified modules associated with fibrosis.ConclusionsOur results provide a rich resource for the design of experiments to understand mechanisms underlying fibrosis and for rational strain selection when testing antifibrotic drugs.

Published
2021

4. An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

Author

Keller, Caroline Gubser, Shin, Youngah, Monteys, Alex Mas, Renaud, Nicole, Beibel, Martin, Teider, Natalia, Peters, Thomas, Faller, Thomas, St-Cyr, Sophie, Knehr, Judith, Roma, Guglielmo, Reyes, Alejandro, Hild, Marc, Lukashev, Dmitriy, Theil, Diethilde, Dales, Natalie, Cha, Jang-Ho, Borowsky, Beth, Dolmetsch, Ricardo, Davidson, Beverly L., and Sivasankaran, Rajeev

Published
2022
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6. Loss of Hepatic Lgr4 and Lgr5 Promotes Nonalcoholic Fatty Liver Disease

Author

Saponara, Enrica, Penno, Carlos, Orsini, Vanessa, Wang, Zhong-Yi, Fischer, Audrey, Aebi, Alexandra, Matadamas-Guzman, Meztli L., Brun, Virginie, Fischer, Benoit, Brousseau, Margaret, O’Donnell, Peter, Turner, Jonathan, Meyer, Alexandra Graff, Bollepalli, Laura, d’Ario, Giovanni, Roma, Guglielmo, Carbone, Walter, Annunziato, Stefano, Obrecht, Michael, Beckmann, Nicolau, Saravanan, Chandra, Osmont, Arnaud, Tropberger, Philipp, Richards, Shola M., Genoud, Christel, Ley, Svenja, Ksiazek, Iwona, Nigsch, Florian, Terracciano, Luigi, Schadt, Heiko S., Bouwmeester, Tewis, Tchorz, Jan S., and Ruffner, Heinz

Published
2022
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7. STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

Author

Morozzi, Giulio, Rothen, Julian, Toussaint, Gauthier, De Lange, Katrina, Westritschnig, Katrin, Doelemeyer, Arno, Ueberschlag, Vanessa Pitiot, Kahle, Peter, Lambert, Christian, Obrecht, Michael, Beckmann, Nicolau, Ritter, Veronique, Panesar, Moh, Stauffer, Daniela, Garnier, Isabelle, Mueller, Matthias, Guerini, Danilo, Keller, Caroline Gubser, Knehr, Judith, Roma, Guglielmo, Bidinosti, Michael, Brachat, Sophie, Morvan, Frederic, and Fornaro, Mara

Published
2021
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8. CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

Author

Cho, Hyelim, Shen, Qiong, Zhang, Lydia H., Okumura, Mikiko, Kawakami, Akinori, Ambrose, Jessi, Sigoillot, Frederic, Miller, Howard R., Gleim, Scott, Cobos-Correa, Amanda, Wang, Ying, Piechon, Philippe, Roma, Guglielmo, Eggimann, Fabian, Moore, Charles, Aspesi, Peter, Jr., Mapa, Felipa A., Burks, Heather, Ross, Nathan T., Krastel, Philipp, Hild, Marc, Maimone, Thomas J., Fisher, David E., Nomura, Daniel K., Tallarico, John A., Canham, Stephen M., Jenkins, Jeremy L., and Forrester, William C.

Published
2021
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9. BET bromodomain inhibitors regulate keratinocyte plasticity

Author

Schutzius, Gabi, Kolter, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola M., Louis, Malvina, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Chris, Thomas, Jason R., Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul W., Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Keller, Caroline Gubser, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori L., Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Tewis, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix, and Kirkland, Susan

Published
2021
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10. Molecular characterization of chronic cutaneous wounds reveals subregion‐ and wound type‐specific differential gene expression

Author

Richards, Shola Michelle, primary, Gubser Keller, Caroline, additional, Kreutzer, Robert, additional, Greiner, Géraldine, additional, Ley, Svenja, additional, Doelemeyer, Arno, additional, Dubost, Valerie, additional, Flandre, Thierry, additional, Kirkland, Susan, additional, Carbone, Walter, additional, Pandya, Rishika, additional, Knehr, Judith, additional, Roma, Guglielmo, additional, Schuierer, Sven, additional, Bouchez, Laure, additional, Seuwen, Klaus, additional, Aebi, Alexandra, additional, Westhead, David, additional, Hintzen, Gabriele, additional, Jurisic, Giorgia, additional, Hossain, Imtiaz, additional, Neri, Marilisa, additional, Manevski, Nenad, additional, Balavenkatraman, Kamal Kumar, additional, Moulin, Pierre, additional, Begrich, Annette, additional, Bertschi, Barbara, additional, Huber, Roland, additional, Bouwmeester, Tewis, additional, Driver, Vickie R., additional, von Schwabedissen, Moritz, additional, Schaefer, Dirk, additional, Wettstein, Barbara, additional, Wettstein, Reto, additional, and Ruffner, Heinz, additional

Published
2023
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12. PAX8 and MECOM are interaction partners driving ovarian cancer

Author

Bleu, Melusine, Mermet-Meillon, Fanny, Apfel, Verena, Barys, Louise, Holzer, Laura, Bachmann Salvy, Marianne, Lopes, Rui, Amorim Monteiro Barbosa, Inês, Delmas, Cecile, Hinniger, Alexandra, Chau, Suzanne, Kaufmann, Markus, Haenni, Simon, Berneiser, Karolin, Wahle, Maria, Moravec, Ivana, Vissières, Alexandra, Poetsch, Tania, Ahrné, Erik, Carte, Nathalie, Voshol, Johannes, Bechter, Elisabeth, Hamon, Jacques, Meyerhofer, Marco, Erdmann, Dirk, Fischer, Matteo, Stachyra, Therese, Freuler, Felix, Gutmann, Sascha, Fernández, César, Schmelzle, Tobias, Naumann, Ulrike, Roma, Guglielmo, Lawrenson, Kate, Nieto-Oberhuber, Cristina, Cobos-Correa, Amanda, Ferretti, Stephane, Schübeler, Dirk, and Galli, Giorgio Giacomo

Published
2021
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13. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Author

Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., and Beckwith, Rohan E. J.

Published
2020
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14. Molecular characterization of chronic cutaneous wounds reveals subregion‐ and wound type‐specific differential gene expression.

Author

Richards, Shola Michelle, Gubser Keller, Caroline, Kreutzer, Robert, Greiner, Géraldine, Ley, Svenja, Doelemeyer, Arno, Dubost, Valerie, Flandre, Thierry, Kirkland, Susan, Carbone, Walter, Pandya, Rishika, Knehr, Judith, Roma, Guglielmo, Schuierer, Sven, Bouchez, Laure, Seuwen, Klaus, Aebi, Alexandra, Westhead, David, Hintzen, Gabriele, and Jurisic, Giorgia

Subjects
TRAUMA surgery, RNA analysis, EPITHELIAL cells, LEG ulcers, LIGANDS (Chemistry), RESEARCH funding, CLINICAL trials, BLOOD vessels, STENOSIS, FOOT ulcers, DECISION making in clinical medicine, GENE expression, IMMUNOHISTOCHEMISTRY, GENES, METABOLISM, PROTEOLYTIC enzymes, GENE expression profiling, MOLECULAR biology, PATHOLOGIC neovascularization, SURGICAL site, CHRONIC wounds & injuries, DRUG discovery, HISTOLOGY, SEQUENCE analysis, PRESSURE ulcers, BIOMARKERS
Abstract

A limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various common chronic ulcer types to facilitate drug discovery strategies. We conducted a comprehensive analysis of leg ulcers (LUs), encompassing venous and arterial ulcers, foot ulcers (FUs), pressure ulcers (PUs), and compared them with surgical wound healing complications (WHCs). To explore the pathophysiological mechanisms and identify similarities or differences within wounds, we dissected wounds into distinct subregions, including the wound bed, border, and peri‐wound areas, and compared them against intact skin. By correlating histopathology, RNA sequencing (RNA‐Seq), and immunohistochemistry (IHC), we identified unique genes, pathways, and cell type abundance patterns in each wound type and subregion. These correlations aim to aid clinicians in selecting targeted treatment options and informing the design of future preclinical and clinical studies in wound healing. Notably, specific genes, such as PITX1 and UPP1, exhibited exclusive upregulation in LUs and FUs, potentially offering significant benefits to specialists in limb preservation and clinical treatment decisions. In contrast, comparisons between different wound subregions, regardless of wound type, revealed distinct expression profiles. The pleiotropic chemokine‐like ligand GPR15L (C10orf99) and transmembrane serine proteases TMPRSS11A/D were significantly upregulated in wound border subregions. Interestingly, WHCs exhibited a nearly identical transcriptome to PUs, indicating clinical relevance. Histological examination revealed blood vessel occlusions with impaired angiogenesis in chronic wounds, alongside elevated expression of genes and immunoreactive markers related to blood vessel and lymphatic epithelial cells in wound bed subregions. Additionally, inflammatory and epithelial markers indicated heightened inflammatory responses in wound bed and border subregions and reduced wound bed epithelialization. In summary, chronic wounds from diverse anatomical sites share common aspects of wound pathophysiology but also exhibit distinct molecular differences. These unique molecular characteristics present promising opportunities for drug discovery and treatment, particularly for patients suffering from chronic wounds. The identified diagnostic markers hold the potential to enhance preclinical and clinical trials in the field of wound healing. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Supplemental Figure 6: Analysis of spleens from APCMin mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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21. Supplemental Figure 3: High MS-444 concentrations impede intestinal epithelial re-epithelialization and induce HuR nucleocytoplasmic shuttling in an acute colitis model. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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22. Supplemental Figure 4: CRISPR/Cas9 HuR ko in RAW 264.7 macrophage cells. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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23. Supplemental Figure 2: Small intestinal crypt-villus length and HuR subcellular distribution in tumors. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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24. Supplemental Figure 1: Weight curves, DSS water consumption, colonoscopy and tumor localization in APCMin mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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25. Supplemental Figure 7: Chao1 and Shannon richness estimates and indicator OTUs for AOM/DSS mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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26. Supplemental Figure 5: Immune cell infiltration in intestinal tumors and cytokine expression in small intestinal organoids upon MS-444. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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27. Supplemental methods and references from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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28. Supplemental tables 1-3 from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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29. Supplemental Figure 8: Chao1 and Shannon richness estimates and indicator OTUs for AOM/DSS mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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30. Data from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

Author

Lang, Michaela, primary, Berry, David, primary, Passecker, Katharina, primary, Mesteri, Ildiko, primary, Bhuju, Sabin, primary, Ebner, Florian, primary, Sedlyarov, Vitaly, primary, Evstatiev, Rayko, primary, Dammann, Kyle, primary, Loy, Alexander, primary, Kuzyk, Orest, primary, Kovarik, Pavel, primary, Khare, Vineeta, primary, Beibel, Martin, primary, Roma, Guglielmo, primary, Meisner-Kober, Nicole, primary, and Gasche, Christoph, primary

Published
2023
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31. Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease

Author

Saponara, Enrica, primary, Penno, Carlos, additional, Orsini, Vanessa, additional, Wang, Zhong-Yi, additional, Fischer, Audrey, additional, Aebi, Alexandra, additional, Matadamas-Guzman, Meztli L., additional, Brun, Virginie, additional, Fischer, Benoit, additional, Brousseau, Margaret, additional, O'Donnell, Peter, additional, Turner, Jonathan, additional, Graff Meyer, Alexandra, additional, Bollepalli, Laura, additional, d’Ario, Giovanni, additional, Roma, Guglielmo, additional, Carbone, Walter, additional, Annunziato, Stefano, additional, Obrecht, Michael, additional, Beckmann, Nicolau, additional, Saravanan, Chandra, additional, Osmont, Arnaud, additional, Tropberger, Philipp, additional, Richards, Shola M., additional, Genoud, Christel, additional, Ley, Svenja, additional, Ksiazek, Iwona, additional, Nigsch, Florian, additional, Terracciano, Luigi M., additional, Schadt, Heiko S., additional, Bouwmeester, Tewis, additional, Tchorz, Jan S., additional, and Ruffner, Heinz, additional

Published
2023
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32. CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Author

Bidinosti, Michael, Botta, Paolo, Krüttner, Sebastian, Proenca, Catia C., Stoehr, Natacha, Bernhard, Mario, Fruh, Isabelle, Mueller, Matthias, Bonenfant, Debora, Voshol, Hans, Carbone, Walter, Neal, Sarah J., McTighe, Stephanie M., Roma, Guglielmo, Dolmetsch, Ricardo E., Porter, Jeffrey A., Caroni, Pico, Bouwmeester, Tewis, Lüthi, Andreas, and Galimberti, Ivan

Published
2016

33. IRF2 is a master regulator of human keratinocyte stem cell fate

Author

Mercado, Nicolas, Schutzius, Gabi, Kolter, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, John, Alford, John, Russ, Carsten, Knehr, Judith, Hoepfner, Dominic, Aebi, Alexandra, Ruffner, Heinz, Beck, Tanner C., Jagannathan, Sajjeev, Olson, Calla M., Sheppard, Hadley E., Elsarrag, Selma Z., Bouwmeester, Tewis, Frederiksen, Mathias, Lohmann, Felix, Lin, Charles Y., and Kirkland, Susan

Published
2019
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36. Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Author

Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., and Beckwith, Rohan E. J.

Published
2020
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37. Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi

Author

Mitchell, Gabriel, primary, Roma, Guglielmo, additional, Voorberg-van der Wel, Annemarie, additional, Beibel, Martin, additional, Zeeman, Anne-Marie, additional, Schuierer, Sven, additional, Torres, Laura, additional, Flannery, Erika L, additional, Kocken, Clemens HM, additional, Mikolajczak, Sebastian A., additional, and Diagana, Thierry T., additional

Published
2022
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38. Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

Author

Dhandapani, Rahul, primary, Neri, Marilisa, additional, Bernhard, Mario, additional, Brzak, Irena, additional, Schweizer, Tatjana, additional, Rudin, Stefan, additional, Joller, Stefanie, additional, Berth, Ramon, additional, Kernen, Jasmin, additional, Neuhaus, Anna, additional, Waldt, Annick, additional, Cuttat, Rachel, additional, Naumann, Ulrike, additional, Keller, Caroline Gubser, additional, Roma, Guglielmo, additional, Feuerbach, Dominik, additional, Shimshek, Derya R., additional, Neumann, Ulf, additional, Gasparini, Fabrizio, additional, and Galimberti, Ivan, additional

Published
2022
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39. The genome of melon (Cucumis melo L.)

Author

Garcia-Mas, Jordi, Benjak, Andrej, Sanseverino, Walter, Bourgeois, Michael, Mir, Gisela, González, Víctor M., Hénaff, Elizabeth, Câmara, Francisco, Cozzuto, Luca, Lowy, Ernesto, Alioto, Tyler, Capella-Gutiérrez, Salvador, Blanca, Jose, Cañizares, Joaquín, Ziarsolo, Pello, Gonzalez-Ibeas, Daniel, Rodríguez-Moreno, Luis, Droege, Marcus, Du, Lei, Alvarez-Tejado, Miguel, Lorente-Galdos, Belen, Melé, Marta, Yang, Luming, Weng, Yiqun, Navarro, Arcadi, Marques-Bonet, Tomas, Aranda, Miguel A., Nuez, Fernando, Picó, Belén, Gabaldón, Toni, Roma, Guglielmo, Guigó, Roderic, Casacuberta, Josep M., Arús, Pere, and Puigdomènech, Pere

Published
2012

41. Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis

Author

Ungricht, Rosemarie, primary, Guibbal, Laure, additional, Lasbennes, Marie-Christine, additional, Orsini, Vanessa, additional, Beibel, Martin, additional, Waldt, Annick, additional, Cuttat, Rachel, additional, Carbone, Walter, additional, Basler, Anne, additional, Roma, Guglielmo, additional, Nigsch, Florian, additional, Tchorz, Jan S., additional, Hoepfner, Dominic, additional, and Hoppe, Philipp S., additional

Published
2022
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42. Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease

Author

Saponara, Enrica, primary, Penno, Carlos, additional, Matadamas Guzmán, Meztli L., additional, Brun, Virginie, additional, Fischer, Benoit, additional, Brousseau, Margaret, additional, Wang, Zhong-Yi, additional, ODonnell, Peter, additional, Turner, Jonathan, additional, Meyer, Alexandra Graff, additional, Bollepalli, Laura, additional, d’Ario, Giovanni, additional, Roma, Guglielmo, additional, Carbone, Walter, additional, Orsini, Vanessa, additional, Annunziato, Stefano, additional, Obrecht, Michael, additional, Beckmann, Nicolau, additional, Saravanan, Chandra, additional, Osmont, Arnaud, additional, Tropberger, Philipp, additional, Richards, Shola, additional, Genoud, Christel, additional, Aebi, Alexandra, additional, Ley, Svenja, additional, Ksiazek, Iwona, additional, Nigsch, Florian, additional, Terraciano, Luigi, additional, Bouwmeester, Tewis, additional, Tchorz, Jan, additional, and Ruffner, Heinz, additional

Published
2021
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43. Persistence of Plasmodium cynomolgi hypnozoites in cynomolgus monkey iPS-derived hepatocytes

Author

Pellisson, Melanie, primary, Zeeman, Anne-Marie, additional, Doll, Thierry, additional, Kirchhofer-Allan, Lucy, additional, Schuierer, Sven, additional, Roma, Guglielmo, additional, Flannery, Erika L., additional, Mikolajczak, Sebastian A., additional, Kocken, Clemens H.M., additional, Maeser, Pascal, additional, Rottmann, Matthias, additional, and Mueller, Matthias, additional

Published
2021
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44. NEURODEVELOPMENT: CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Author

Bidinosti, Michael, Botta, Paolo, Kriittner, Sebastian, Proenca, Catia C., Stoehr, Natacha, Bernhard, Mario, Fruh, Isabelle, Mueller, Matthias, Bonenfant, Debora, Voshol, Hans, Carbone, Walter, Neal, Sarah J., McTighe, Stephanie M., Roma, Guglielmo, Dolmetsch, Ricardo E., Porter, Jeffrey A., Caroni, Pico, Bouwmeester, Tewis, Lüthi, Andreas, and Galimberti, Ivan

Published
2016
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45. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Author

Sun, Tianliang, primary, Annunziato, Stefano, additional, Bergling, Sebastian, additional, Sheng, Caibin, additional, Orsini, Vanessa, additional, Forcella, Pascal, additional, Pikiolek, Monika, additional, Kancherla, Venkatesh, additional, Holwerda, Sjoerd, additional, Imanci, Dilek, additional, Wu, Fabian, additional, Meylan, Ludivine Challet, additional, Puehringer, Lea F., additional, Waldt, Annick, additional, Oertli, Mevion, additional, Schuierer, Sven, additional, Terracciano, Luigi M., additional, Reinker, Stefan, additional, Ruffner, Heinz, additional, Bouwmeester, Tewis, additional, Sailer, Andreas W., additional, George, Elizabeth, additional, Roma, Guglielmo, additional, de Weck, Antoine, additional, Piscuoglio, Salvatore, additional, Lohmann, Felix, additional, Naumann, Ulrike, additional, Liberali, Prisca, additional, Cong, Feng, additional, and Tchorz, Jan S., additional

Published
2021
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48. Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens

Author

Montazeri, Hesam, primary, Coto-Llerena, Mairene, additional, Bianco, Gaia, additional, Zangene, Ehsan, additional, Taha-Mehlitz, Stephanie, additional, Paradiso, Viola, additional, Srivatsa, Sumana, additional, de Weck, Antoine, additional, Roma, Guglielmo, additional, Lanzafame, Manuela, additional, Bolli, Martin, additional, Beerenwinkel, Niko, additional, von Flüe, Markus, additional, Terracciano, Luigi M, additional, Piscuoglio, Salvatore, additional, and Ng, Charlotte K Y, additional

Published
2021
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49. Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens

Author

Lopes, Rui, primary, Sprouffske, Kathleen, additional, Sheng, Caibin, additional, Uijttewaal, Esther C. H., additional, Wesdorp, Adriana Emma, additional, Dahinden, Jan, additional, Wengert, Simon, additional, Diaz-Miyar, Juan, additional, Yildiz, Umut, additional, Bleu, Melusine, additional, Apfel, Verena, additional, Mermet-Meillon, Fanny, additional, Krese, Rok, additional, Eder, Mathias, additional, Olsen, André Vidas, additional, Hoppe, Philipp, additional, Knehr, Judith, additional, Carbone, Walter, additional, Cuttat, Rachel, additional, Waldt, Annick, additional, Altorfer, Marc, additional, Naumann, Ulrike, additional, Weischenfeldt, Joachim, additional, deWeck, Antoine, additional, Kauffmann, Audrey, additional, Roma, Guglielmo, additional, Schübeler, Dirk, additional, and Galli, Giorgio G., additional

Published
2021
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50. Abstract 2025: Characterization of cancer cell lines made senescent by exposure to ribociclib, doxorubicin, or TGFβ1, and identification of genes required for entry into senescence and senescent cell survival

Author

Rao, Pasupuleti, primary, Tullai, Jennifer, additional, Aspesi, Peter, additional, Mapa, Felipa, additional, Cochran, Nadire, additional, Sigoillot, Frederic, additional, Roma, Guglielmo, additional, Gleim, Scott, additional, Jacob, Jaison, additional, Marchese, Jason, additional, and Solomon, Jonathan, additional

Published
2021
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