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3 results on '"Román E.M."'

1. Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

Author

Stephens, Camilla, primary, Robles-Diaz, Mercedes, additional, Medina-Caliz, Inmaculada, additional, Garcia-Cortes, Miren, additional, Ortega-Alonso, Aida, additional, Sanabria-Cabrera, Judith, additional, Gonzalez-Jimenez, Andres, additional, Alvarez-Alvarez, Ismael, additional, Slim, Mahmoud, additional, Jimenez-Perez, Miguel, additional, Gonzalez-Grande, Rocio, additional, Fernández, M. Carmen, additional, Casado, Marta, additional, Soriano, German, additional, Román, Eva, additional, Hallal, Hacibe, additional, Romero-Gomez, Manuel, additional, Castiella, Agustin, additional, Conde, Isabel, additional, Prieto, Martin, additional, Moreno-Planas, Jose Maria, additional, Giraldez, Alvaro, additional, Moreno-Sanfiel, J. Miguel, additional, Kaplowitz, Neil, additional, Lucena, M. Isabel, additional, Andrade, Raúl J., additional, Andrade, R.J., additional, Lucena, M.I., additional, Stephens, C., additional, Cortés, M. García, additional, Robles-Díaz, M., additional, Ortega-Alonso, A., additional, Pinazo, J., additional, Muñoz, B. García, additional, Alcántara, R., additional, Hernández, A., additional, Escaño, M.D. García, additional, del Campo, E., additional, Medina-Cáliz, I., additional, Sanabria-Cabrera, J., additional, González-Jiménez, A., additional, Sanjuán-Jiménez, R., additional, Cueto, A., additional, Álvarez-Álvarez, I., additional, Bonilla, E., additional, Di Zeo, D., additional, Niu, H., additional, Villanueva, M., additional, Papineau, A., additional, Pérez, M. Jiménez, additional, Grande, R. González, additional, Ortega, S. López, additional, Santaella, I., additional, Ocaña, A., additional, Palomino, P., additional, Fernández, M.C., additional, Peláez, G., additional, Porcel, A., additional, Casado, M., additional, Sánchez, M. González, additional, Romero-Gómez, M., additional, Millán-Domínguez, R., additional, Fombuena, B., additional, Gallego, R., additional, Ampuero, J., additional, Campo, J.A. del, additional, Calle-Sanz, R., additional, Rojas, L., additional, Rojas, A., additional, Gómez, A. Gil, additional, Vilar, E., additional, Soriano, G., additional, Guarner, C., additional, Román, E.M., additional, Manuitt, M.A. Quijada, additional, Arbos, R.M. Antonijoan, additional, Delgado, J. Sánchez, additional, Gómez, M. Vergara, additional, Hallal, H., additional, Oltra, E. García, additional, Arcos, J.C. Titos, additional, Martínez, A. Pérez, additional, Cobarro, C. Sánchez, additional, Caparrós, J.M. Egea, additional, Castiella, A., additional, Zapata, E., additional, Arenas, J., additional, García, A. Gómez, additional, Esandi, F.J., additional, Blanco, S., additional, Odriozola, P. Martínez, additional, Crespo, J., additional, Iruzubieta, P., additional, Cabezas, J., additional, Gallego, A. Giráldez, additional, Rodríguez Seguel, E. del P., additional, Cuaresma, M., additional, Gallego, J. González, additional, Jorquera, F., additional, Campos, S. Sánchez, additional, Otazua, P., additional, de Juan Gómez, A., additional, Salmerón, J., additional, Gila, A., additional, Quiles, R., additional, González, J.M., additional, Lorenzo, S., additional, Prieto, M., additional, Amiel, I. Conde, additional, Berenguer, M., additional, García-Eliz, M., additional, Primo, J., additional, Molés, J.R., additional, Garayoa, A., additional, Carrascosa, M., additional, Domínguez, E. Gómez, additional, Cuevas, L., additional, Farré, M., additional, Montané, E., additional, Barriocanal, A.M., additional, Arellano, A.L., additional, Sanz, Y., additional, Morillas, R.M., additional, Sala, M., additional, Ridaura, H. Masnou, additional, Bruguera, M., additional, Gines, P., additional, Lens, S., additional, García, J.C., additional, Mariño, Z., additional, Guerra, M. Hernández, additional, Sanfiel, J.M. Moreno, additional, Fernández del Campo, C. Boada, additional, Tejedor, M., additional, Ferrer, R. González, additional, Fernández, C., additional, Gil, M. Fernández, additional, Montero, J.L., additional, Mata, M. de la, additional, Olmo, J. Fuentes, additional, Bonilla, E.M. Fernández, additional, Moreno, J.M., additional, Martínez-Rodenas, P., additional, Garrido, M., additional, Oliva, C., additional, Rendón, P., additional, Samaniego, J. García, additional, Madejón, A., additional, Calleja, J.L., additional, Porras, J.L. Martínez, additional, Cabriada, J.L., additional, Pérez-Moreno, J.M., additional, and Lara, C., additional

Published
2021
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2. Clinical Characteristics and Outcome of Drug‐Induced Liver Injury in the Older Patients: From the Young‐Old to the Oldest‐Old

Author

Weersink, Rianne A., primary, Alvarez‐Alvarez, Ismael, additional, Medina‐Cáliz, Inmaculada, additional, Sanabria‐Cabrera, Judith, additional, Robles‐Díaz, Mercedes, additional, Ortega‐Alonso, Aida, additional, García‐Cortés, Miren, additional, Bonilla, Elvira, additional, Niu, Hao, additional, Soriano, German, additional, Jimenez‐Perez, Miguel, additional, Hallal, Hacibe, additional, Blanco, Sonia, additional, Kaplowitz, Neil, additional, Lucena, M. Isabel, additional, Andrade, Raúl J., additional, Andrade, R.J., additional, Lucena, M.I., additional, Stephens, C., additional, García Cortés, M., additional, Robles Díaz, M., additional, Ortega Alonso, A., additional, Pinazo, J., additional, García Muñoz, B., additional, Alcántara, R., additional, Hernández, A., additional, García‐Escaño, M.D., additional, Medina‐Cáliz, I., additional, Sanabria‐Cabrera, J., additional, Alvarez‐Alvarez, I., additional, Bonilla, E., additional, Niu, H., additional, Di‐Zeo, D., additional, Del Campo, E., additional, Jiménez Pérez, M., additional, González Grande, R., additional, López Ortega, S., additional, Santaella, I., additional, Ocaña, A., additional, Palomino, P., additional, Fernández, M.C., additional, Porcel, A., additional, Casado, M., additional, González Sánchez, M., additional, Romero‐Gómez, M., additional, Millán‐Domínguez, R., additional, Fombuena, B., additional, Gallego, R., additional, Ampuero, J., additional, del Campo, J.A., additional, Calle‐Sanz, R., additional, Rojas, L., additional, Rojas, A., additional, Gil Gómez, A., additional, Vilar, E., additional, Soriano, G., additional, Guarner, C., additional, Román, E.M., additional, Quijada Manuitt, M.A., additional, Antonijoan Arbos, R.M., additional, Farré, M., additional, Montané, E., additional, Arellano, A.L., additional, Barriocanal, A.M., additional, Sanz, Y., additional, Morillas, R.M., additional, Sala, M., additional, Masnou Ridaura, H., additional, Sánchez Delgado, J., additional, Vergara Gómez, M., additional, Hallal, H., additional, García Oltra, E., additional, Titos Arcos, J.C., additional, Pérez Martínez, A., additional, Sánchez Cobarro, C., additional, Egea Caparrós, J.M., additional, Castiella, A., additional, Arenas, J., additional, Gomez Osua, M.I., additional, Gómez García, A., additional, Esandi, F.J., additional, Blanco, S., additional, Martínez Odriozola, P., additional, Crespo, J., additional, Iruzubieta, P., additional, Cabezas, J., additional, Giráldez Gallego, A., additional, Rodríguez Seguel, E. del P., additional, Cuaresma, M., additional, Prieto, M., additional, Conde Amiel, I., additional, Berenguer, M., additional, García‐Eliz, M., additional, Moreno, J.M., additional, Martínez‐Rodenas, P., additional, Garrido, M., additional, Oliva, C., additional, Gómez Domínguez, E., additional, Cabrera, L., additional, Cuevas, L., additional, Bruguera, M., additional, Gines, P., additional, Lens, S., additional, García, J.C., additional, Mariño, Z., additional, Hernández Guerra, M., additional, Moreno San Fiel, M., additional, Boada Fernández del Campo, C., additional, Fuentes Olmo, J., additional, Fernández Bonilla, E.M., additional, Jorquera, F., additional, and González Gallego, J., additional

Published
2020
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3. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs

Author

Urban, TJ, Shen, YF, Stolz, A, Chalasani, N, Fontana, RJ, Rochon, J, Ge, DL, Shianna, KV, Daly, AK, Lucena, MI, Nelson, MR, Molokhia, M, Aithal, GP, Floratos, A, Pe'er, I, Serrano, J, Bonkovsky, H, Davern, TJ, Lee, WM, Navarro, VJ, Talwalkar, JA, Goldstein, DB, Watkins, PB, Guarner C., Soriano G., Román E.M., and Drug-Induced Liver Injury Network

Subjects
genome-wide association study, drug-induced liver injury, pharmacogenetics
Abstract

Background and aims Drug-induced liver injury (DILI) is a serious adverse drug event that is suspected to have a heritable component. We carried out a genome-wide association study of 783 individuals of European ancestry who experienced DILI due to more than 200 implicated drugs. Methods DILI patients from the US-based Drug-Induced Liver Injury Network (n=401) and three international registries (n=382) were genotyped with the Illumina 1Mduo BeadChip and compared with population controls (n=3001). Potential associations were tested in 307 independent Drug-Induced Liver Injury Network cases. Results After accounting for known major histocompatibility complex risk alleles for flucloxacillin-DILI and amoxicillin/clavulanate-DILI, there were no genome-wide significant associations, including in the major histocompatibility complex region. Stratification of DILI cases according to clinical phenotypes (injury type, latency, age of onset) also did not show significant associations. An analysis of hepatocellular DILI (n=285) restricted to 193 single-nucleotide polymorphisms previously associated with autoimmune disease showed a trend association for rs7574865, in the vicinity of signal transducer and activator of transcription 4 (STAT4) (P=4.5 x 10(-4)). This association was replicated in an independent cohort of 168 hepatocellular DILI cases (P=0.011 and 1.5 x 10(-5) for combined cohorts). No significant associations were found with stratification by other clinical or demographic variables. Conclusion Although not significant at the genome-wide level, the association between hepatocellular DILI and STAT4 is consistent with the emerging role of the immune system in DILI. However, the lack of genome-wide association study findings supports the idea that strong genetic determinants of DILI may be largely drug-specific or may reflect rare genetic variations, which were not assessed in our study. Pharmacogenetics and Genomics 22:784-795 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Published
2012

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