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5 results on '"Román Alonso, Macarena"'

1. Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors

Author

Román Alonso, Macarena, Grinyó-Escuer, Ariadna, Duro-Sánchez, Santiago, Rius-Ruiz, Irene, Bort-Brusca, Marta, Escorihuela, Marta, Maqueda-Marcos, Susana, Pérez-Ramos, Sandra, Gago, Judit, Nogales, Vanesa, Espinosa-Bravo, Martín, Peg, Vicente, Escrivá-de-Romaní, Santiago, Foradada, Laia, Soucek, Laura, Braña, Irene, Galvao, Vladimir, Martín-Lluesma, Silvia, Moessner, Ekkehard, Klein, Christian, Garralda, Elena, Saura, Cristina, and Arribas, Joaquín

Published
2024
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5. Three-dimensional cell culture of chimeric antigen receptor T cells originated from peripheral blood mononuclear cells towards cellular therapies

Author

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Max Planck Society, European Commission, Rius, Irene [0000-0002-6097-7572], Castellote Borrell, Miquel [0000-0001-7703-2228], Guasch, Judith [0000-0002-3571-4711], Pérez del Río, Eduardo, Román Alonso, Macarena, Rius, Irene, Santos, Fabiao, Castellote Borrell, Miquel, Veciana, Jaume, Ratera, Imma, Arribas, Joaquín, Guasch, Judith, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Max Planck Society, European Commission, Rius, Irene [0000-0002-6097-7572], Castellote Borrell, Miquel [0000-0001-7703-2228], Guasch, Judith [0000-0002-3571-4711], Pérez del Río, Eduardo, Román Alonso, Macarena, Rius, Irene, Santos, Fabiao, Castellote Borrell, Miquel, Veciana, Jaume, Ratera, Imma, Arribas, Joaquín, and Guasch, Judith

Abstract

Background aims: With the objective of improving the ex vivo production of therapeutic chimeric antigen receptor (CAR) T cells, we explored the addition of three-dimensional (3D) polystyrene scaffolds to standard suspension cell cultures.Methods: We aimed to mimic the structural support given by the lymph nodes during in vivo lymphocyte expansion.Results: We observed an increase in cell proliferation compared with standard suspension systems as well as an enhanced cytotoxicity toward cancer cells. Moreover, we directly obtained the CART cells from peripheral blood mononuclear cells, thus minimizing the ex vivo manipulation of the therapeutic cells and opening the way to synergies among different cell populations.Conclusions: We propose the use of commercially available 3D polystyrene systems to improve the current immune cell cultures and resulting cell products for emerging cellular (immuno)therapies.(c) 2023 International Society for Cell & Gene Therapy.

Published
2023

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