157 results on '"Román, Paula"'
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2. The effects of silica aerogel on the rheological behaviour and polymer matrix structure of Rigid Polyurethane foams
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Cimavilla-Román, Paula, Perez-Tamarit, Saul, Vananroye, Anja, Moldenaers, Paula, and Ángel Rodriguez-Pérez, Miguel
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- 2022
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3. Dynamic Mechanical Analysis during polyurethane foaming: Relationship between modulus build-up and reaction kinetics
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Cimavilla-Román, Paula, Santiago-Calvo, Mercedes, and Rodríguez-Pérez, Miguel Ángel
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- 2021
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4. Influence of silica aerogel particles on the foaming process and cellular structure of rigid polyurethane foams
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Cimavilla-Román, Paula, Pérez-Tamarit, Saul, Santiago-Calvo, Mercedes, and Rodríguez-Pérez, Miguel Ángel
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- 2020
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5. Synthesis and properties of open- and closed-porous foamed glass with a low density
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König, Jakob, Lopez-Gil, Alberto, Cimavilla-Roman, Paula, Rodriguez-Perez, Miguel A., Petersen, Rasmus R., Østergaard, Martin B., Iversen, Niels, Yue, Yuanzheng, and Spreitzer, Matjaž
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- 2020
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6. X-ray radioscopy validation of a polyol functionalized with graphene oxide for producing rigid polyurethane foams with improved cellular structures
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Santiago-Calvo, Mercedes, Pérez-Tamarit, Saúl, Cimavilla-Román, Paula, Blasco, Victoria, Ruiz, Carolina, París, Rodrigo, Villafañe, Fernando, and Rodríguez-Pérez, Miguel Ángel
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- 2019
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7. Technological proximity and the intensity of collaboration along the innovation funnel: direct and joint effects on innovative performance
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Anzola-Román, Paula, Bayona-Sáez, Cristina, García-Marco, Teresa, and Lazzarotti, Valentina
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- 2019
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8. Unveiling the Inner Structure of Micrometric Hollow Polymeric Fibers Using Synchrotron X-Ray Nanotomography.
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Torre, Jorge, Cimavilla-Román, Paula, Cuadra-Rodríguez, Daniel, Rodríguez-Pérez, Miguel Ángel, Guttmann, Peter, Werner, Stephan, Pinto, Javier, and Barroso-Solares, Suset
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- 2024
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9. APLICACIÓN DE LA ROBÓTICA EN EDUCACIÓN
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Román, Paula González, primary, Adamuz, Laura López, additional, Avilés, Noelia López, additional, and Fernández, María José López, additional
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- 2019
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10. Un papel manchado con rouge. 'Amorales suburbanos' en el discurso periodístico durante el primer peronismo. La Plata, 1948/A napkin stained with rouge. 'Suburban amorales' in the journalistic discourse during the first peronism. La Plata, 1948
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Román, Paula E.
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- 2022
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11. Organizational innovation, internal R&D and externally sourced innovation practices: Effects on technological innovation outcomes
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Anzola-Román, Paula, Bayona-Sáez, Cristina, and García-Marco, Teresa
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- 2018
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12. Epidemic history and baseline resistance to NS5A-specific direct acting drugs of hepatitis C virus in Spain
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Palladino, Claudia, Ezeonwumelu, Ifeanyi Jude, Mate-Cano, Irene, Borrego, Pedro, Martínez-Román, Paula, Arca-Lafuente, Sonia, Resino, Salvador, Taveira, Nuno, and Briz, Verónica
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- 2020
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13. Estudio de derivaciones de Atención Primaria a centros de Salud Mental en pacientes adultos en la Comunidad de Madrid
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Díaz, Juan, Díaz-de-Neira, Mónica, Jarabo, Andrea, Roig, Pilar, and Román, Paula
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- 2017
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14. Comparison of methods and characterization of small RNAs from plasma extracellular vesicles of HIV/HCV coinfected patients
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Martínez-González, Elena, Brochado-Kith, Óscar, Gómez-Sanz, Alicia, Martín-Carbonero, Luz, Jimenez-Sousa, Ma Ángeles, Martínez-Román, Paula, Resino, Salvador, Briz, Verónica, and Fernández-Rodríguez, Amanda
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- 2020
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15. COMPONENTE DE PRODUCCIÓN
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Jaramillo, Elizabeth Aponte, primary, Román, Paula A.Garizado, additional, and Heredia, Javier Andrés Castro, additional
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- 2019
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16. Bjerg María, Lazos rotos. La inmigración, el matrimonio y las emociones en la Argentina entre los siglos XIX y XX
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Román, Paula E.
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- 2021
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17. The Influence of CSR Orientation on Innovative Performance: Is the Effect Conditioned to the Implementation of Organizational Practices?
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Anzola-Román, Paula, primary, Garcia-Marco, Teresa, additional, and Zouaghi, Ferdaous, additional
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- 2023
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18. HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study
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López-Huertas, Maria Rosa, Palladino, Claudia, Garrido-Arquero, Marta, Esteban-Cartelle, Beatriz, Sánchez-Carrillo, Marta, Martínez-Román, Paula, Martín-Carbonero, Luz, Ryan, Pablo, Domínguez-Domínguez, Lourdes, Santos, Ignacio De Los, Moral, Sara De La Fuente, Benito, José Miguel, Rallón, Norma, Alcamí, José, Resino, Salvador, Fernández-Rodríguez, Amanda, Coiras, Mayte, Briz, Verónica, and on behalf of the Multidisciplinary Group of viral coinfection HIV/Hepatitis (COVIHEP)
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- 2019
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19. The effects of silica aerogel on the rheological behaviour and polymer matrix structure of Rigid Polyurethane foams
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Cimavilla Román, Paula and Cimavilla Román, Paula
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Producción Científica, The incorporation of silica aerogel particles into the isocyanate used to prepare Rigid Polyurethane composite foams drastically modifies its rheological behaviour. The isocyanate changes from being a Newtonian fluid of constant viscosity (0.3 Pa s at 25 °C) to a non-linear power-law material with complex viscosity decreasing from 104 to 101 Pa s with a slope −1 versus frequency. The change in response is caused by the formation of a percolated network of particles at contents above 2.5 wt% of aerogel. Moreover, the addition of aerogel significantly slows down the modulus-build up kinetics and vitrification of the matrix by approximately 4.5 min with every 1 wt% of aerogel added. For the foam with 3.0 wt% of aerogel, the combination of high viscosity at early reaction times coupled with the slow modulus build-up impedes the drainage which leads to a decrease in the fraction of material in the struts of the matrix., Junta de Castilla y Leon (project VA202P20), Ministerio de Ciencia, Innovación y Universidades (projects RTI2018-098749-B-I00 and RTI2018 - 097367-A-I00)
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- 2022
20. Dynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance
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Instituto de Salud Carlos III, European Commission, National Institutes of Health (US), Fundação para a Ciência e a Tecnologia (Portugal), Lara-Aguilar, Violeta [0000-0003-0015-5961], Martín-Carbonero, Luz [0000-0001-8102-4079], Ryan, Pablo [0000-0002-4212-7419], De Los Santos, Ignacio [0000-0001-7073-5211], Fernández-Rodríguez, Amanda [0000-0002-5110-2213], Briz, Verónica [0000-0003-2297-5098], Martínez-Román, Paula, Crespo-Bermejo, Celia, Valle-Millares, Daniel, Lara-Aguilar, Violeta, Arca-Lafuente, Sonia, Martín-Carbonero, Luz, Ryan, Pablo, De Los Santos, Ignacio, López-Huertas, María Rosa, Palladino, Claudia, Muñoz Muñoz, María, Fernández-Rodríguez, Amanda, Coiras, Mayte, Briz, Verónica, Instituto de Salud Carlos III, European Commission, National Institutes of Health (US), Fundação para a Ciência e a Tecnologia (Portugal), Lara-Aguilar, Violeta [0000-0003-0015-5961], Martín-Carbonero, Luz [0000-0001-8102-4079], Ryan, Pablo [0000-0002-4212-7419], De Los Santos, Ignacio [0000-0001-7073-5211], Fernández-Rodríguez, Amanda [0000-0002-5110-2213], Briz, Verónica [0000-0003-2297-5098], Martínez-Román, Paula, Crespo-Bermejo, Celia, Valle-Millares, Daniel, Lara-Aguilar, Violeta, Arca-Lafuente, Sonia, Martín-Carbonero, Luz, Ryan, Pablo, De Los Santos, Ignacio, López-Huertas, María Rosa, Palladino, Claudia, Muñoz Muñoz, María, Fernández-Rodríguez, Amanda, Coiras, Mayte, and Briz, Verónica
- Abstract
Background: Although human immunodeficiency virus type 1 (HIV-1) reservoir size is very stable under antiretroviral therapy (ART), individuals exposed to the Hepatitis C virus (HCV) (chronically coinfected and spontaneous clarifiers) show an increase in HIV reservoir size and in spliced viral RNA, which could indicate that the viral protein regulator Tat is being more actively synthesized and, thus, could lead to a higher yield of new HIV. However, it is still unknown whether the effect of HCV elimination with direct-acting antivirals (DAAs) could modify the HIV reservoir and splicing. Methods: This longitudinal study (48 weeks’ follow-up after sustained virological response) involves 22 HIV+-monoinfected individuals, 17 HIV+/HCV- spontaneous clarifiers, and 24 HIV+/HCV+ chronically infected subjects who eliminated HCV with DAAs (all of them aviremic, viral load < 50). Viral-spliced RNA transcripts and proviral DNA copies were quantified by qPCR. Paired samples were analyzed using a mixed generalized linear model. Results: A decrease in HIV proviral DNA was observed in HIV+/HCV- subjects, but no significant differences were found for the other study groups. An increased production of multiple spliced transcripts was found in HIV+ and HIV+/HCV+ individuals. Conclusions: We conclude that elimination of HCV by DAAs was unable to revert the consequences derived from chronic HCV infection for the reservoir size and viral splicing, which could indicate an increased risk of rapid HIV-reservoir reactivation. Moreover, spontaneous clarifiers showed a significant decrease in the HIV reservoir, likely due to an enhanced immune response in these individuals.
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- 2022
21. T cell maturation and senescence after HCV cure in HIV-HCV coinfected patients: a prospective study
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Martínez-Román, Paula, primary, Cortegano, Isabel, additional, Millares, Daniel Valle, additional, Crespo-Bermejo, Celia, additional, Rallón, Norma, additional, Benito, José Miguel, additional, Lara-Aguilar, Violeta, additional, Arca-Lafuente, Sonia, additional, Martín-Carbonero, Luz, additional, Domínguez-Domínguez, Lourdes, additional, Ryan, Pablo, additional, Santos, Ignacio de los, additional, Coiras, Mayte, additional, Palladino, Claudia, additional, Gaspar, María Luisa, additional, Fernández-Rodríguez, Amanda, additional, and Briz, Verónica, additional
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- 2022
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22. Sub-pixel Tomographic Methods for Characterizing the Solid Architecture of Foams
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Cimavilla-Román, Paula, primary, Pérez-Tamarit, Saúl, additional, Barroso-Solares, Suset, additional, Pinto, Javier, additional, and Rodríguez-Pérez, Miguel Ángel, additional
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- 2022
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23. Different HCV exposure drives specific miRNA profile in PBMCS of HIV patients
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Valle-Millares, Daniel, Brochado-Kith, Óscar, Martín-Carbonero, Luz, Domínguez-Domínguez, Lourdes, Ryan, Pablo, De los Santos, Ignacio, De la Fuente, Sara, Castro, Juan M., Lagarde, María, Cuevas, Guillermo, Mayoral-Muñoz, Mario, Matarranz, Mariano, Díez, Victorino, Gómez-Sanz, Alicia, Martínez-Román, Paula, Crespo-Bermejo, Celia, Palladino, Claudia, Muñoz-Muñoz, María, Jiménez-Sousa, María A., Resino, Salvador, Briz, Verónica, Fernández-Rodríguez, Amanda, Multidisciplinary Group of Viral Coinfection HIV/Hepatitis, UAM. Departamento de Medicina, Instituto de Salud Carlos III, Fundación Universidad Alfonso X el Sabio, Fundación Banco Santander, Red de Investigación Cooperativa en Investigación en Sida, Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), Repositório da Universidade de Lisboa, Universidad Alfonso X El Sabio, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Valle-Millares, Daniel, Brochado-Kith, Óscar, Martín-Carbonero, Luz, Domínguez-Domínguez, Lourdes, Ryan, Pablo, De Los Santos, Ignacio, Lagarde, María, Cuevas, Guillermo, Matarranz, Mariano, Díez, Victorino, Gómez-Sanz, Alicia, Crespo-Bermejo, Celia, Palladino, Claudia, Muñoz-Muñoz, María, Jiménez-Sousa, María A, Resino, Salvador, Briz, Verónica, and Fernández-Rodríguez, Amanda
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QH301-705.5 ,Medicina ,Human immunodeficiency virus (HIV) ,Medicine (miscellaneous) ,Acute infection ,medicine.disease_cause ,PI3K signaling ,Peripheral blood mononuclear cell ,General Biochemistry, Genetics and Molecular Biology ,Article ,chemistry.chemical_compound ,Spontaneous viral clearance ,microRNA ,medicine ,Biology (General) ,Gene ,business.industry ,virus diseases ,HIV ,Virology ,digestive system diseases ,MicroRNAs ,chemistry ,High throughput sequence ,Antifolate ,HCV ,Hiv patients ,business - Abstract
18 Pág. Departamento de Mejora Genética Animal, Micro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs and interact with the miRNA-mediated host response. We aim to analyze the miRNA profile of HIV patients with different exposure to HCV to explore specific signatures in the miRNA profile of PBMCs for each type of infection. We massively sequenced small RNAs of PBMCs from 117 HIV+ infected patients: 45 HIV+ patients chronically infected with HCV (HIV/HCV+), 36 HIV+ that spontaneously clarified HCV after acute infection (HIV/HCV-) and 36 HIV+ patients without previous HCV infection (HIV). Thirty-two healthy patients were used as healthy controls (HC). Differential expression analysis showed significantly differentially expressed (SDE) miRNAs in HIV/HCV+ (n = 153), HIV/HCV- (n = 169) and HIV (n = 153) patients. We found putative dysregulated pathways, such as infectious-related and PI3K signaling pathways, common in all contrasts. Specifically, putatively targeted genes involved in antifolate resistance (HIV/HV+), cancer-related pathways (HIV/HCV-) and HIF-signaling (HIV) were identified, among others. Our findings revealed that HCV strongly influences the expression profile of PBMCs from HIV patients through the disruption of its miRNome. Thus, different HCV exposure can be identified by specific miRNA signatures in PBMCs., This work has been supported by grants from Institute of Health Carlos III, [PI15CIII/00031 and PI18CIII/00020/ to AFR and VB] and the Foundation Universidad Alfonso X el Sabio-Santander [grant number 1.010.932 to AFR] and the Spanish AIDS Research Network (RD16CIII/0002/0002), and Centro de Investigación Biomédica en Red (CIBER) en Enfermedades Infecciosas (CB21/13/00044). AFR is supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) [CP14/CIII/00010 and CPII20CIII/0001]
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- 2021
24. HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization
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Valle-Millares, Daniel, primary, Brochado-Kith, Óscar, additional, Gómez-Sanz, Alicia, additional, Martín-Carbonero, Luz, additional, Ryan, Pablo, additional, De los Santos, Ignacio, additional, Castro, Juan M., additional, Troya, Jesús, additional, Mayoral-Muñoz, Mario, additional, Cuevas, Guillermo, additional, Martínez-Román, Paula, additional, Sanz-Sanz, Jesús, additional, Muñoz-Muñoz, María, additional, Jiménez-Sousa, María Á, additional, Resino, Salvador, additional, Briz, Verónica, additional, and Fernández-Rodríguez, Amanda, additional
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- 2022
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25. Cold neutron transmission for the in-situ analysis of the gas diffusion in polymers
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Martín-de León, Judith, primary, Cimavilla-Román, Paula, additional, Bernardo, Victoria, additional, Solórzano, Eusebio, additional, Kardjilov, Nikolai, additional, and Rodríguez-Pérez, Miguel A., additional
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- 2021
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26. Bjerg, María, Lazos rotos. La inmigración, el matrimonio y las emociones en la Argentina entre los siglos XIX y XX : Bernal, Universidad Nacional de Quilmes Editorial, 2019, 128 páginas
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Román, Paula Emilia
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Reseñas de Libros ,Historia - Abstract
Estudiar procesos migratorios implica centrarse en un objeto de por sí esquivo. Las fuentes que registran a las poblaciones migrantes tienden a hacerlo con propósitos cuantitativos: censos, registros parroquiales y civiles conforman sus rastros más evidentes. Por esta razón, la propuesta de un abordaje cualitativo implica construir una mirada original que alumbre aquellas trayectorias con nuevas preguntas. Lazos rotos. La inmigración, el matrimonio y las emociones en la Argentina entre los siglos XIX y XX, de María Bjerg, logra este propósito articulando al menos tres dimensiones. Por un lado, se vale de los aportes conceptuales de la historia de las emociones, un campo de estudios que, aunque ha crecido de manera sostenida en los últimos años, registra un desarrollo aún incipiente en Argentina. Por otro, recurre a un fondo documental escasamente trabajado para el tema, las fuentes judiciales. Finalmente, articula en su mirada una perspectiva de género que le permite mostrar el carácter desigual en el tratamiento de los sujetos frente a la justicia, así como los matices de sus repertorios afectivos., Facultad de Humanidades y Ciencias de la Educación
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- 2021
27. Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy
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Vigón, Lorena, primary, Martínez-Román, Paula, additional, Rodríguez-Mora, Sara, additional, Torres, Montserrat, additional, Puertas, María C., additional, Mateos, Elena, additional, Salgado, María, additional, Navarro, Antonio, additional, Sánchez-Conde, Matilde, additional, Ambrosioni, Juan, additional, Cervero, Miguel, additional, Wyen, Christoph, additional, Hoffmann, Christian, additional, Miró, José M, additional, Alcamí, José, additional, Podzamczer, Daniel, additional, García-Gutiérrez, Valentín, additional, Martínez-Picado, Javier, additional, Briz, Verónica, additional, Rosa López-Huertas, María, additional, Planelles, Vicente, additional, Coiras, Mayte, additional, Corona, Magdalena, additional, del Mar Díaz-Goizueta, María, additional, Knops, Elena, additional, Luna de Abia, Alejandro, additional, Martín-Carbonero, Luz, additional, Ryan, Pablo, additional, and Spivak, Adam, additional
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- 2021
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28. Evaluación perceptual de la insuficiencia velofaríngea en personas con fisura del paladar: una revisión integradora de literatura
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Inostroza-Allende, Felipe, primary, Baeza-Pavez, Gustavo, primary, Del-Valle-Román, Paula, primary, Fernández-Antifil, Jason, primary, Yáñez-Pavez, Constanza, primary, and Pino-Castillo, Josué, primary
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- 2021
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29. Estudio inmuno-virológico del reservorio del Virus de la Inmunodeficiencia Humana tipo 1 en individuos coinfectados por el virus de la hepatitis C. Impacto de la curación del Virus de la Hepatitis C
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Martínez Román, Paula, Briz Sebastián, Verónica, Universidad de Alcalá. Departamento de Biología de Sistemas, and Universidad de Alcalá. Programa de Doctorado en Ciencias de la Salud
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Microbiología Clínica ,Biología Molecular de Microorganismos ,Virología (VIH/VHC) ,Microbiología (VIH/VHC) ,Biology ,Biología y Biomedicina - Abstract
Actualmente existen 2,75 millones de personas coinfectadas con el virus de la inmunodeficiencia humana (VIH) y el virus de la hepatitis C (VHC) en el mundo. Estudios previos han mostrado que la coinfección altera la historia natural de ambas enfermedades, empeorando el pronóstico de los pacientes. Aunque hoy en día es posible eliminar la infección por VHC gracias a los nuevos antivirales de acción directa (AADs), todavía no existe una cura para la infección por VIH debido a la persistencia del virus en reservorios latentes inaccesibles al tratamiento antirretorival. Aumentar el conocimiento sobre las consecuencias de la exposición al VHC y la eliminación del mismo en el contexto de la infección por el VIH-1 es crucial a la hora de desarrollar estrategias para el buen manejo de este tipo de pacientes. El presente trabajo identificó un mayor tamaño del reservorio del VIH-1 en individuos coinfectados con infección crónica, así como en individuos aclaradores espontáneos de la infección por el VHC comparados con sujetos monoinfectados VIH+. Respecto a la actividad transcripcional viral, se observó una mayor expresión de transcritos de ARN mensajero viral single y multiple spliced en pacientes coinfectados con infección crónica dada la activación persistente de su sistema inmunitario. Sin embargo, no se encontraron correlaciones evidentes entre el tamaño del reservorio y el splicing viral del VIH-1 para ninguno de los grupos de estudio, probablemente como consecuencia de la integración de provirus en zonas con baja actividad transcripcional y de la acumulación de provirus defectuosos. De igual modo, se observó que la eliminación del VHC con AADs no logra resolver el impacto que la infección crónica por VHC tiene en el reservorio viral del VIH. La estabilización del reservorio viral en estos pacientes se ve reforzada por el éxito del tratamiento antirretroviral y el incremento en la expresión de transcritos virales multiple spliced en células no quiescentes, lo que podría conducir a un desarrollo temprano de SIDA si la terapia fuese discontinuada. Sin embargo, con el tiempo, los pacientes aclaradores espontáneos del VHC son capaces de disminuir el tamaño del reservorio viral, posiblemente debido a la presencia de una respuesta antiviral potente en su organismo, así como a un sistema inmunitario robusto. Por último, el análisis de la evolución de las poblaciones celulares T de memoria muestra un descenso generalizado de la inmunosenescencia gracias a la disminución de la estimulación antigénica de células específicas frente al VIH-1 y al VHC. Además, el descenso en la proporción de células con fenotipo TH1 en individuos aclaradores espontáneos podría relacionarse con el declive en el tamaño del reservorio de los mismos, probablemente debido a su compartimentalización en células T cooperadoras foliculares con este fenotipo y a la normalización de la respuesta inmune inflamatoria.
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- 2021
30. Persistencia de brechas en la región Pacífico de Colombia: Consideraciones para un modelo de subregionalización
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Vivas Pacheco, Harvy, Arroyo Mina, Santiago, Garizado Román, Paula, Galeano Loaiza, Juber, Rodriguez Caporalli, Enrique, Cortes Landázury, Raúl, and Álvarez Correa, Juan Fernando
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Brechas ,Pacífico (Región, Colombia) ,Economic development ,Asociatividad territorial ,Descentralización ,Desarrollo económico ,Factores endógenos - Abstract
Los esquemas de asociatividad territorial, que tienen una relación clave con las formas de subregionalización, representan la apuesta estratégica que permite acelerar el desarrollo económico con enfoque de equidad. En la región Pacífico de Colombia (RPC) se presentan grandes diferencias al interior de sus subregiones, siendo necesaria una gestión integral del territorio que permita una mejor aplicación de la política pública, logrando disminuir las disparidades y potencializando el desarrollo endógeno de su crecimiento. Mediante el contraste de indicadores subregionales, a través del análisis exploratorio de datos espaciales, se validó el esquema asociativo territorial propuesto por el Plan Estratégico Regional (PER) en la conformación de la región Administrativa y de Planificación del Pacífico (RAP Pacífico). Los resultados confirman la presencia de un modelo de desarrollo monocéntrico, acentuado en el corazón del Pacífico Andino, así como disparidades subregionales que se incrementan con la distancia a este foco de desarrollo. Como recomendación principal, se sugiere la creación de un Observatorio de Estudios Regionales del Pacífico que, a partir de la producción, recopilación, análisis y evaluación de información estadística territorial para las variables asociadas a las dimensiones del desarrollo, contribuya a la orientación y la toma de mejores decisiones de política pública, además que realice seguimiento y evaluación de impacto para las mismas en toda la región
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- 2021
31. University spin-offs: a case study on their characterization, challenges and entrepreneurship ecosystem
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Anzola Román, Paula, Bayona Sáez, Cristina, Universidad Pública de Navarra. Departamento de Gestión de Empresas, and Nafarroako Unibertsitate Publikoa. Enpresen Kudeaketa Saila
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Case study ,Entrepreneurship ,Ambidexteriry ,Technology-based companies ,Entrepreneurial ecosystem ,University spin-offs - Abstract
University has moved away from the ‘ivory tower’ conceptualization that characterized it as an isolated and inexpugnable knowledge fortress. On the contrary, universities fully participate today of a system, acting the main agent for the dissemination of knowledge and technological change, but permeating its borders to be in full contact with its context. Academic literature, noting these transformations, has coined the term ‘entrepreneurial university’, to refer to this institution that interacts with private companies and other economic agents, exploiting entrepreneurship opportunities, and thus contributing to economic and social development. Within the context of the ‘entrepreneurial university’, this work focuses on business initiatives arising from academic R&D activities. For this purpose, the research provides a comparative study and a multiple case study based on in-depth interviews with the founding leaders of six firms constituted as spin-offs from the Public University of Navarra (henceforward, UPNA) and other agents related. The objective is to determine a characterization for these types of firms, with the aim of contributing to the literature regarding the phenomenon of university spin-offs and its idiosyncrasy. In turn, this work intends also to identify the main challenges faced by these firms, and to carry out an exploratory study on how the entrepreneurship ecosystem –promoted by the University- helps in overcoming these challenges. In this sense, the results of the analysis highlight the difficulties regarding the need to combine practices to explore disruptive technologies with the need to guarantee a sustainable model for the exploitation of the products developed by these spin-offs. Therefore, this study concludes that the main challenge for university spin-offs is ambidexterity. In addition, it elaborates on the relevance of the support instruments provided by the ecosystem, which intend to complement the initial deficiencies of university spin-offs in matters of management and commercial strategy. This insight is undoubtedly useful for practitioners, researches and policy makers alike.
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- 2021
32. Design and validation of experimental methods for probing foam formation dynamics and cellular structure
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Cimavilla Román, Paula, Rodríguez Pérez, Miguel Ángel, and Universidad de Valladolid. Escuela de Doctorado
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2210.90 Química-Física de Polímeros ,Polímeros ,Polimeros y polimerización ,Cellular Materials ,Polymers ,Foams ,Espumas ,Materiales Celulares - Abstract
The present thesis focuses on the development of new experimental techniques to study the process-structure-properties relationship in polymeric foams. To achieve this objective rigid polyurethane (RPU) foams were studied. Methodologies have been developed to investigate the synthesis of RPU foams from complementary rheological, physicochemical and structural points of view. To validate the potential of the methods, the effect of different catalyst and blowing agent concentrations on the synthesis of these foams has been systematically studied. As a result of this research, new methods of characterisation of the synthesis process have been obtained at laboratory level, these are based on Dynamic Mechanical Analysis (DMA), Shear Rheology, as well as X-ray tomography and X-ray radioscopy. Furthermore, the development and application of these techniques has allowed to understand the effect of micrometric Silica Aerogel particles on the synthesis, cellular structure and thermal insulation properties of RPU foams reinforced with these particles. The joint evaluation of the reaction kinetics, polymer matrix development and cell structure of RPU foams has identified new ways for the future improvement and optimisation of RPU-Aerogel composite materials with great potential to replace traditional thermal insulators. The present thesis is part of the research activities carried out in the CellMat Laboratory of the Department of Condensed Matter Physics of the University of Valladolid and has been supervised by Prof. Dr. Miguel Ángel Rodríguez-Pérez, director of this laboratory and professor at the University of Valladolid. This thesis has been written as a compendium of eight publications, five of which have already been published in international journals. In addition, this thesis meets the requirements to be accredited with an International Mention., La presente tesis se centra en el desarrollo de nuevas técnicas experimentales para estudiar la relación proceso-estructura-propiedades en las espumas poliméricas. Para alcanzar este objetivo se estudiaron principalmente espumas de poliuretano rígido (RPU). Se han desarrollado metodologías que permiten investigar la síntesis de las espumas de RPU desde puntos de vista complementarios, reológico, fisicoquímicos y estructural. Para validar el potencial de los métodos se ha estudiado de forma sistemática el efecto de distintas concentraciones de catalizador y agente espumante en la síntesis de estas espumas. Como resultado de esta investigación se han podido obtener nuevos métodos de caracterización a nivel de laboratorio del proceso de síntesis, basados en Análisis Mecánico Dinámico (DMA), Reología de Cizalla, así como tomografía y radioscopía de rayos X. Además, el desarrollo y aplicación de estas técnicas ha permitido comprender el efecto de partículas micrométricas de Aerogel de Silice en la síntesis, estructura celular y propiedades de aislamiento térmico de espumas de RPU reforzadas con dichas partículas. La evaluación conjunta de las cinética de reacción, desarrollo de la matriz polimérica y de la estructura celular de las espumas de RPU ha permitido identificar vías para la mejora y optimización futura de materiales compuestos de RPU-Aerogel con gran potencial para sustituir a los aislantes térmicos tradicionales. La presente tesis es parte de las actividades de investigación desarrolladas en el Laboratorio CellMat del Departamento de Física de la Materia Condensada de la Universidad de Valladolid y ha sido supervisada por el Prof. Dr. Miguel Ángel Rodríguez-Pérez, director de este laboratorio y catedrático de la Universidad de Valladolid. Esta tesis se ha escrito como compendio de ocho publicaciones, cinco de las cuales ya han sido publicadas en revistas internacionales. Además, esta tesis reúne los requerimientos para ser acreditada con Mención Internacional., Escuela de Doctorado, Doctorado en Física
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- 2021
33. La Caldera. No. 24
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Afanador Díaz, Gisela, Gélvez, Leydi Johanna, Navas Cadena, María Carolina, Mora Moreno, Sandro, Rodríguez Sarmiento, Samir, Rocío Silva, Pilar, Hassen, Clara María, Ayala, Laura Melissa, Brijaldo, Elena Mireya, Cárdenas, Yadira Vanessa, Vásquez Gómez, Valeria, Diaz Hernández, Leyla, Leal Vargas, Juan David, Acevedo Palacios, Mía Gabriela, Villabona Afanador, Andrea, Carvajal Amaya, Karol Sofía, Bonilla Román, Paula, Camacho Maldonado, Anna Lucía, Zarate Melo, Bianca Emiliana, Sarabia Roa, María Camila, Narváez Solano, María Constanza, Quiroga Ramírez, Harvey, Gómez Lizarazo, Diego Fernando, Herrera Gamboa, Laura Camila, Camargo Sanguino, Samuel, Mantilla Durán, Sarah Sophie, Duarte Solano, Silvia Daniela, Zea Arenas, Yatana, Salazar Jaimes, Claudia Lucía, Afanador Díaz, Gisela, and Afanador Díaz, Gisela [0000085586]
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Caldist masters ,Culture diffusion ,Reading aloud contest ,Intercollegiate departmental speech contest ,Preescolar ,Concurso de lectura en voz alta ,School press ,Preschool ,Augusto Monterroso ,Prensa escolar ,Experiencias internacionales ,Solar watch ,Cradle of Excelsior ,Reloj solar ,Cuna de Excélsior ,Alfonso Gómez Gómez ,Caldist expressions ,Noticias escolares ,Homenaje ,Difusión de la cultura ,Actividades culturales ,Concurso intercolegiado departamental de oratoria ,International experiences ,Cultural activities ,Maestros caldistas ,Expresiones caldistas ,Tribute ,School news - Abstract
El poder extraordinario que tiene la literatura, en la vida de un ser humano, es incalculable; no sólo es abrir un libro y pasar los ojos por las páginas; ¡No! Es dejarse atrapar, dejarse llevar por mundos y contextos distintos, diversos, pletóricos de vivencias humanas que nos hacen únicos e irrepetibles. Cada vez que abrimos un libro y nos damos el permiso de leerlo, nos volvemos mejores seres humanos, porque comprendemos más al otro, o por lo menos, tratamos de reconocer cómo vivían, cómo pensaban, cómo actuaban, en otras épocas, incluyendo la nuestra. Con la lectura, podemos entender por qué los seres humanos son como son, potenciamos la empatía y fortalecemos la conciencia moral, entre algunas ventajas que tiene este proceso que nos acompaña a lo largo de toda la vida. Este año, en la mejor Feria del Libro del Oriente Colombiano, ULIBRO 2021, que se realiza del 30 de agosto, al 4 de septiembre, estamos invitados a participar en conversatorios, talleres, encuentros con autores, entre otras actividades propuestas, de manera presencial y virtual, para seguir fortaleciendo nuestro proyecto de vida; también, estamos invitados a dejarnos contagiar de la lectura, de la escritura, de la oralidad, a partir de “Las historias asombrosas”, que se van a tomar los diferentes espacios propuestos. 1. Experiencias Internacionales…5 2. Homenaje al Dr. Alfonso Gómez Gómez; Por Samir Rodríguez Sarmiento…12 3. Nuestro Preescolar; Por Pilar Rocío Silva, Clara María Hassen y Laura Melissa Ayala…16 4. Maestros Caldistas; Por Gisela Afanador Díaz y Elena Mireya Brijaldo…20 5. Reloj Solar…24 6. La Cuna de Excélsior. VIII Concurso de Lectura en Voz Alta…29 7. VIII Concurso Intercolegiado Departamental de Oratoria...35 8. Homenaje a Augusto Monterroso; Por comunidad caldista...49 9. Expresiones Caldistas…52 10. Galería de Imágenes…86 11. Nuestros Maestros…92 The extraordinary power that literature has, in the life of a human being, is incalculable; It is not just opening a book and running your eyes through the pages; No! It is to let yourself be trapped, to let yourself be carried away by different, diverse worlds and contexts, full of human experiences that make us unique and unrepeatable. Every time we open a book and give ourselves permission to read it, we become better human beings, because we understand others more, or at least, we try to recognize how they lived, how they thought, how they acted, in other times, including ours. . With reading, we can understand why human beings are the way they are, we enhance empathy and strengthen moral conscience, among some advantages that this process has that accompanies us throughout our lives. This year, in the best Book Fair of the Colombian East, ULIBRO 2021, which takes place from August 30 to September 4, we are invited to participate in talks, workshops, meetings with authors, among other proposed activities, in person and virtual, to continue strengthening our life project; Also, we are invited to let ourselves be infected with reading, writing, orality, starting from "The amazing stories", which are going to take the different spaces proposed.
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- 2021
34. Dynamic Mechanical Analysis during polyurethane foaming: Relationship between modulus build-up and reaction kinetics
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Cimavilla Román, Paula and Cimavilla Román, Paula
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Producción Científica, The modulus build-up and relative density evolution during the reactive foaming of four standard polyurethane formulations was monitored in-situ by Dynamic Mechanical Analysis (DMA) with a customised set-up in parallel plate geometry. The modulus increased from 0.01 MPa in the first minutes to over 1.2 MPa within 20 min. The set-up also enabled the recording of vitrification followed by curing times. These typically occur within 3 min of each other. The results of DMA are corroborated by measurements of the reaction kinetics with Infrared Spectroscopy. This goes to show that the modulus remains nearly unchanged during the stage of swiftest isocyanate conversion, while the point of gel conversion is accompanied by their increase., Junta de Castilla y León (grant VA202P20), Ministerio de Ciencia, Innovación y Universidades (grant RTI2018-098749-B-I00)
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- 2021
35. HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization
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Instituto de Salud Carlos III, Fundación Universidad Alfonso X el Sabio, Valle-Millares, Daniel [0000-0002-5205-855X], Muñoz Muñoz, María [0000-0003-3805-2108], Jiménez-Sousa, María Angeles [0000-0002-1945-6169], Valle-Millares, Daniel, Brochado-Kith, Óscar, Gómez-Sanz, Alicia, Martín-Carbonero, Luz, Ryan, Pablo, De Los Santos, Ignacio, Castro, Juan M., Troya, Jesús, Mayoral-Muñoz, Mario, Cuevas, G., Martínez-Román, Paula, Sanz-Sanz, Jesús, Muñoz Muñoz, María, Jiménez-Sousa, María Angeles, Resino, Salvador, Briz, Verónica, Fernández-Rodríguez, Amanda, Instituto de Salud Carlos III, Fundación Universidad Alfonso X el Sabio, Valle-Millares, Daniel [0000-0002-5205-855X], Muñoz Muñoz, María [0000-0003-3805-2108], Jiménez-Sousa, María Angeles [0000-0002-1945-6169], Valle-Millares, Daniel, Brochado-Kith, Óscar, Gómez-Sanz, Alicia, Martín-Carbonero, Luz, Ryan, Pablo, De Los Santos, Ignacio, Castro, Juan M., Troya, Jesús, Mayoral-Muñoz, Mario, Cuevas, G., Martínez-Román, Paula, Sanz-Sanz, Jesús, Muñoz Muñoz, María, Jiménez-Sousa, María Angeles, Resino, Salvador, Briz, Verónica, and Fernández-Rodríguez, Amanda
- Abstract
Gender-specific consequences after HCV eradication are unexplored. MicroRNAs (miRNAs) play a crucial role in the immune response against viral infections. However, few have highlighted miRNA role in sex-biased disease or therapy response. We aim to assess gender differences reflected in the miRNA expression of HIV/HCV-coinfected patients who achieve sustained virological response (SVR) with direct acting antivirals (DAAs). We conducted a prospective study of miRNA expression in PBMCs from 28 chronic HIV/HCV-coinfected patients (HIV/HCV) at baseline and after achieving SVR with DAAs. Sixteen HIV-monoinfected patients (HIV) and 36 healthy controls (HC) were used as controls. Identification of significant differentially expressed (SDE) miRNAs was performed with generalized linear model and mixed GLMs. We also explored putative dysregulated biological pathways. At baseline, the HIV/HCV patients showed differences in the miRNA profile concerning the HIV group (165 and 102 SDE miRNAs for males and females, respectively). Gender-stratified analysis of HIV/HCV group at baseline versus at SVR achievement showed higher differences in males (80 SDE miRNAs) than in females (55 SDE miRNAs). After SVR, HIV/HCV group showed similar values to HIV individuals, especially in females (1 SDE miRNA). However, ten miRNAs in males remained dysregulated, which were mainly involved in cancer, fatty acid, and inflammatory pathways. Taken together, our results show gender-biased dysregulation in the miRNA expression profile of PBMCs after HCV eradication with DAAs. These differences were normalized in females, while miRNA profile and their target-related pathways in males lack of normalization, which may be related to a high-risk of developing liver-related complications.
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- 2021
36. Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients
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Instituto de Salud Carlos III, Universidad Alfonso X El Sabio, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Valle-Millares, Daniel [0000-0002-5205-855X], Brochado-Kith, Óscar [0000-0001-8372-2604], Martín-Carbonero, Luz [0000-0001-8102-4079], Domínguez-Domínguez, Lourdes [0000-0001-6018-9026], Ryan, Pablo [0000-0002-4212-7419], De Los Santos, Ignacio [0000-0001-7073-5211], Lagarde, María [0000-0002-7712-6977], Cuevas, G. [0000-0001-7875-6359], Matarranz, Mariano [0000-0002-6120-7545], Díez, Victorino [0000-0003-1679-133X], Gómez-Sanz, Alicia [0000-0003-4674-3005], Crespo-Bermejo, Celia [0000-0002-2813-2481], Palladino, Claudia [0000-0002-8148-0928], Muñoz Muñoz, María [0000-0001-7875-6359], Jiménez-Sousa, María Angeles [0000-0002-1945-6169], Resino, Salvador [0000-0001-8783-0450], Briz, Verónica [0000-0003-2297-5098], Fernández-Rodríguez, Amanda [0000-0002-5110-2213], Valle-Millares, Daniel, Brochado-Kith, Óscar, Martín-Carbonero, Luz, Domínguez-Domínguez, Lourdes, Ryan, Pablo, De Los Santos, Ignacio, De la Fuente, Sara, Castro, Juan M., Lagarde, María, Cuevas, G., Mayoral-Muñoz, Mario, Matarranz, Mariano, Díez, Victorino, Gómez-Sanz, Alicia, Martínez-Román, Paula, Crespo-Bermejo, Celia, Palladino, Claudia, Muñoz Muñoz, María, Jiménez-Sousa, María Angeles, Resino, Salvador, Briz, Verónica, Fernández-Rodríguez, Amanda, Instituto de Salud Carlos III, Universidad Alfonso X El Sabio, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Valle-Millares, Daniel [0000-0002-5205-855X], Brochado-Kith, Óscar [0000-0001-8372-2604], Martín-Carbonero, Luz [0000-0001-8102-4079], Domínguez-Domínguez, Lourdes [0000-0001-6018-9026], Ryan, Pablo [0000-0002-4212-7419], De Los Santos, Ignacio [0000-0001-7073-5211], Lagarde, María [0000-0002-7712-6977], Cuevas, G. [0000-0001-7875-6359], Matarranz, Mariano [0000-0002-6120-7545], Díez, Victorino [0000-0003-1679-133X], Gómez-Sanz, Alicia [0000-0003-4674-3005], Crespo-Bermejo, Celia [0000-0002-2813-2481], Palladino, Claudia [0000-0002-8148-0928], Muñoz Muñoz, María [0000-0001-7875-6359], Jiménez-Sousa, María Angeles [0000-0002-1945-6169], Resino, Salvador [0000-0001-8783-0450], Briz, Verónica [0000-0003-2297-5098], Fernández-Rodríguez, Amanda [0000-0002-5110-2213], Valle-Millares, Daniel, Brochado-Kith, Óscar, Martín-Carbonero, Luz, Domínguez-Domínguez, Lourdes, Ryan, Pablo, De Los Santos, Ignacio, De la Fuente, Sara, Castro, Juan M., Lagarde, María, Cuevas, G., Mayoral-Muñoz, Mario, Matarranz, Mariano, Díez, Victorino, Gómez-Sanz, Alicia, Martínez-Román, Paula, Crespo-Bermejo, Celia, Palladino, Claudia, Muñoz Muñoz, María, Jiménez-Sousa, María Angeles, Resino, Salvador, Briz, Verónica, and Fernández-Rodríguez, Amanda
- Abstract
Micro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs and interact with the miRNA-mediated host response. We aim to analyze the miRNA profile of HIV patients with different exposure to HCV to explore specific signatures in the miRNA profile of PBMCs for each type of infection. We massively sequenced small RNAs of PBMCs from 117 HIV+ infected patients: 45 HIV+ patients chronically infected with HCV (HIV/HCV+), 36 HIV+ that spontaneously clarified HCV after acute infection (HIV/HCV-) and 36 HIV+ patients without previous HCV infection (HIV). Thirty-two healthy patients were used as healthy controls (HC). Differential expression analysis showed significantly differentially expressed (SDE) miRNAs in HIV/HCV+ (n = 153), HIV/HCV- (n = 169) and HIV (n = 153) patients. We found putative dysregulated pathways, such as infectious-related and PI3K signaling pathways, common in all contrasts. Specifically, putatively targeted genes involved in antifolate resistance (HIV/HV+), cancer-related pathways (HIV/HCV-) and HIF-signaling (HIV) were identified, among others. Our findings revealed that HCV strongly influences the expression profile of PBMCs from HIV patients through the disruption of its miRNome. Thus, different HCV exposure can be identified by specific miRNA signatures in PBMCs.
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- 2021
37. Dynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance.
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Martínez-Román, Paula, Crespo-Bermejo, Celia, Valle-Millares, Daniel, Lara-Aguilar, Violeta, Arca-Lafuente, Sonia, Martín-Carbonero, Luz, Ryan, Pablo, de los Santos, Ignacio, López-Huertas, María Rosa, Palladino, Claudia, Muñoz-Muñoz, María, Fernández-Rodríguez, Amanda, Coiras, Mayte, and Briz, Verónica
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HIV , *VIRAL load , *HEPATITIS C virus , *TAT protein , *VIRAL proteins - Abstract
Background: Although human immunodeficiency virus type 1 (HIV-1) reservoir size is very stable under antiretroviral therapy (ART), individuals exposed to the Hepatitis C virus (HCV) (chronically coinfected and spontaneous clarifiers) show an increase in HIV reservoir size and in spliced viral RNA, which could indicate that the viral protein regulator Tat is being more actively synthesized and, thus, could lead to a higher yield of new HIV. However, it is still unknown whether the effect of HCV elimination with direct-acting antivirals (DAAs) could modify the HIV reservoir and splicing. Methods: This longitudinal study (48 weeks' follow-up after sustained virological response) involves 22 HIV+-monoinfected individuals, 17 HIV+/HCV- spontaneous clarifiers, and 24 HIV+/HCV+ chronically infected subjects who eliminated HCV with DAAs (all of them aviremic, viral load < 50). Viral-spliced RNA transcripts and proviral DNA copies were quantified by qPCR. Paired samples were analyzed using a mixed generalized linear model. Results: A decrease in HIV proviral DNA was observed in HIV+/HCV- subjects, but no significant differences were found for the other study groups. An increased production of multiple spliced transcripts was found in HIV+ and HIV+/HCV+ individuals. Conclusions: We conclude that elimination of HCV by DAAs was unable to revert the consequences derived from chronic HCV infection for the reservoir size and viral splicing, which could indicate an increased risk of rapid HIV-reservoir reactivation. Moreover, spontaneous clarifiers showed a significant decrease in the HIV reservoir, likely due to an enhanced immune response in these individuals. [ABSTRACT FROM AUTHOR]
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- 2022
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38. Modelling of the mechanisms of heat transfer in recycled glass foams
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Cimavilla-Román, Paula, primary, Villafañe-Calvo, Juan, additional, López-Gil, Alberto, additional, König, Jakob, additional, and Rodríguez-Perez, Miguel Ángel, additional
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- 2021
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39. Influence of silica aerogel particles on the foaming process and cellular structure of rigid polyurethane foams
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Cimavilla Román, Paula and Cimavilla Román, Paula
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Producción Científica, Water blown rigid polyurethane (RPU) composite foams were produced using different concentrations of nanoporous silica aerogel micrometric powder (0.5, 1 and 3 wt%). The effect of these particles on the foaming kinetics was analysed from a physical and chemical viewpoint. On the physical side, the foaming process was studied by in-situ X-ray radioscopy. The inclusion of aerogel particles in the system delays the foam expansion and enhances the nucleation of cells. However, high amounts of these particles (3 wt%) lead to intense cell coalesce during foam evolution. On the chemical side, the reaction kinetics was investigated by in-situ FTIR spectroscopy and reaction temperature measurements. The addition of low contents of aerogel (below 3 wt%) reduces the conversion of isocyanate while favouring the generation of urethane groups, which explains the higher density of the foams with low aerogel contents. However, the foam with high contents of aerogel (3 wt%) does not change the reaction balance in comparison to the reference. Therefore, this foam presents similar expansion and density to those of the unfilled foam (Reference). Furthermore, higher reaction temperatures were reached by the reference foam during the foaming process, and higher dissipation speeds of these temperatures were detected for the foams containing aerogel with respect to those of the reference foam., Junta de Castilla y León (project VA275P18), Ministerio de Ciencia, Innovación y Universidades (project RTI2018-098749-B-I00)
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- 2020
40. University Spin-Offs: A Case Study on Their Characterization, Challenges and Entrepreneurship Ecosystem.
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Anzola-Román, Paula and Bayona-Sáez, Cristina
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ENTREPRENEURSHIP education ,ENTREPRENEURSHIP ,PUBLIC universities & colleges ,DISRUPTIVE innovations ,SOCIAL development ,ECOSYSTEMS - Abstract
University has moved away from the ‘ivory tower’ conceptualization that characterized it as an isolated and inexpugnable knowledge fortress. On the contrary, universities fully participate today of a system, acting the main agent for the dissemination of knowledge and technological change, but permeating its borders to be in full contact with its context. Academic literature, noting these transformations, has coined the term ‘entrepreneurial university’, to refer to this institution that interacts with private companies and other economic agents, exploiting entrepreneurship opportunities, and thus contributing to economic and social development. Within the context of the ‘entrepreneurial university’, this work focuses on business initiatives arising from academic R&D activities. For this purpose, the research provides a comparative study and a multiple case study based on in-depth interviews with the founding leaders of six firms constituted as spin-offs from the Public University of Navarra (henceforward, UPNA) and other agents related. The objective is to determine a characterization for these types of firms, with the aim of contributing to the literature regarding the phenomenon of university spin-offs and its idiosyncrasy. In turn, this work intends also to identify the main challenges faced by these firms, and to carry out an exploratory study on how the entrepreneurship ecosystem –promoted by the University- helps in overcoming these challenges. In this sense, the results of the analysis highlight the difficulties regarding the need to combine practices to explore disruptive technologies with the need to guarantee a sustainable model for the exploitation of the products developed by these spin-offs. Therefore, this study concludes that the main challenge for university spin-offs is ambidexterity. In addition, it elaborates on the relevance of the support instruments provided by the ecosystem, which intend to complement the initial deficiencies of university spin-offs in matters of management and commercial strategy. This insight is undoubtedly useful for practitioners, researches and policy makers alike. [ABSTRACT FROM AUTHOR]
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- 2021
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41. Hepatitis C Virus Influences HIV-1 Viral Splicing in Coinfected Patients
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Martínez-Román, Paula, primary, López-Huertas, María Rosa, additional, Crespo-Bermejo, Celia, additional, Arca-Lafuente, Sonia, additional, Cortegano, Isabel, additional, Valle-Millares, Daniel, additional, Gaspar, María Luisa, additional, Martín-Carbonero, Luz, additional, Domínguez-Domínguez, Lourdes, additional, Ryan, Pablo, additional, de los Santos, Ignacio, additional, de la Fuente-Moral, Sara, additional, Fernández-Rodríguez, Amanda, additional, Coiras, Mayte, additional, and Briz, Verónica, additional
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- 2020
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42. Nanotechnology: A reality for diagnosis of HCV infectious disease
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Arca-Lafuente, Sonia, primary, Martínez-Román, Paula, additional, Mate-Cano, Irene, additional, Madrid, Ricardo, additional, and Briz, Verónica, additional
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- 2020
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43. Study of primary care referrals to Mental Health centers in adult patients in Madrid Region
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Díaz, Juan, Díaz-de-Neira, Mónica, Jarabo, Andrea, Roig, Pilar, and Román, Paula
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Estudio de partes de interconsulta ,lcsh:Psychology ,Derivación de pacientes ,lcsh:BF1-990 ,Mental health ,Consultation reports study ,Atención primaria ,Primary care ,Salud Mental ,Referral of patients - Abstract
Resumen En el presente trabajo se estudian y analizan variables sociodemográficas, clínicas y asistenciales incluidas en los partes de interconsulta (PIC) que traen los pacientes adultos durante un periodo de 15 días recogidos de forma consecutiva en los meses de marzo a junio del 2015 en tres centros de Salud Mental de Madrid (CSM Colmenar Viejo, CSM Vallecas Villa y CSM Villaverde). El estudio estadístico mediante el análisis de variables descriptivas y variables dicotómicas muestra los siguientes resultados: dos tercios de las derivaciones a salud mental son a psiquiatría y un tercio están destinadas a psicología clínica; el tiempo medio de espera para la primera consulta en psicología es de 74 días frente a 38 días en psiquiatría; el 31% de las derivaciones son con carácter preferente con un tiempo medio de demora de 28 días y la mayor parte de las mismas se dirigen a la especialidad de psiquiatría; las principales patologías derivadas son trastornos de ansiedad, cuadros adaptativos y depresivos; el 46.7% de los pacientes derivados a salud mental toman ya algún psicofármaco; las derivaciones a psicología clínica se realizan con pacientes más jóvenes y menos medicados, con menor carácter de urgencia y con menos especificaciones sobre información diagnóstica y farmacológica en los PIC que las derivaciones a psiquiatría. Estos resultados son en su mayoría coherentes con los encontrados en estudios previos, aunque faltan investigaciones que incluyan varios CSM o analicen la información cualitativa de los PIC de derivación. Abstract In this paper, we analyze the sociodemographic, clinical, and health care variables included in the interconsultation reports (PIC) that bring adult patients over a period of 15 days, collected consecutively in the months of March through June 2015 from three mental health centers in Madrid (Colmenar Viejo CSM, Villaverde CSM, and Vallecas Villa CSM). The statistical analysis of data, including analysis of descriptive variables and dichotomous variables, shows the following results: two thirds of referrals are transfers to psychiatry and one third are transfers to clinical psychology; mean time in the waiting list is 74 days for clinical psychology consultation and 38 days for psychiatry consultation; preferential referrals are 31%, with 28 days of mean time in waiting list, being mostly intended for psychiatry; main referred pathologies are anxiety and adaptive and depressive disorders; 46.7% of patients transferred to mental health were already taking some psychiatric medication; clinical psychology referrals involve significantly younger and less medicated patients, significantly less preferential, and with fewer diagnostic and pharmacologic specifications in the PIC than psychiatry referrals. These results are consistent with previous studies, although we have not found other studies that include more than one mental health center, or analyze qualitative information contained in the inter-consultation reports.
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- 2017
44. Modelización de la conductividad térmica en materiales celulares basados en el vidrio
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Villafañe Calvo, Juan, Rodríguez Pérez, Miguel Ángel, Cimavilla Román, Paula, Villafañe Calvo, Juan, Rodríguez Pérez, Miguel Ángel, and Cimavilla Román, Paula
- Abstract
El objetivo principal de este trabajo de fin de grado es el estudio y la modelización de la conductividad térmica de materiales celulares (también denominados espumas) basados en vidrio. Este material es bastante novedoso, y su principal aplicación es el aislamiento de edificios, debido a su baja conductividad térmica y su alta rigidez específica. En primer lugar, se ha desarrollado un modelo teórico de la conductividad de estas espumas, empleando ecuaciones e información existente en la literatura sobre materiales celulares. A este modelo se han incorporado parámetros descriptores de las fases sólida y gaseosa que forman una serie de espumas de vidrio con diferentes densidades. Estos parámetros son el porcentaje de celda abierta, el tamaño medio de celda, el coeficiente de anisotropía de las celdas y la fracción de masa en las aristas. Posteriormente se ha medido experimentalmente la conductividad térmica de dichas muestras, así como los parámetros que definen su estructura, con el objetivo de validar el modelo teórico. En esta comparación, el modelo ha sido capaz de predecir la conductividad de las muestras con un error del 13%., Grado en Física
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- 2019
45. Enriquecimiento curricular en la Alta Capacidad: el juego como motivación hacia el aprendizaje lógico-matemático
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Marín San Román, Paula
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- 2018
46. Diseño e implementación de una aplicación móvil para turistas que visitan la ciudad de Cádiz en crucero
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Ruiz Román, Paula, Panizo, Laura, Merino-Gomez, Pedro, and Lenguajes y Ciencias de la Computación
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Cádiz - Guías ,Android ,Turismo - Innovaciones tecnológicas ,Cruceros ,Apps ,Aplicaciones informáticas ,Turismo - Trabajos fin de máster - Abstract
El Puerto de la Bahía de Cádiz espera batir su récord de buques de crucero en 2018, con un incremento del 8,69% en relación al año anterior. Además, se ha determinado la posibilidad de convertirse en puerto base de cruceros y la creación de la marca “Cruise Cádiz” con el propósito de impulsar el turismo de cruceros en la localidad. Estas previsiones favorables motivan el trabajo desarrollado en este proyecto, en el que se pretende ofrecer una guía de turismo de la ciudad de Cádiz fácil e interactiva con una aplicación móvil adaptada a las necesidades del usuario que viaja en crucero. Para ello, se realiza el diseño e implementación de un prototipo para dispositivos móviles Android utilizando la herramienta App Inventor 2. De esta manera, se incluye información sobre la ciudad e itinerarios turísticos propuestos, así como distintas funcionalidades y diseño de rutas personalizadas
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- 2018
47. Profiting from collaborative and organizational innovation practices: a research through case studies and quantitative analysis
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Anzola Román, Paula, Bayona Sáez, Cristina, García Marco, María Teresa, Universidad Pública de Navarra. Departamento de Gestión de Empresas, and Nafarroako Unibertsitate Publikoa. Enpresen Kudeaketa Saila
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I+D+i ,Innovación ,R+D+i ,Innovation - Abstract
Esta investigación abarca una amplia variedad de prácticas de innovación, y pretende avanzar en la comprensión sobre el aprovechamiento de las mismas, teniendo en cuenta factores contextuales y los potenciales efectos de su adopción conjunta. En concreto, los estudios que conforman esta tesis profundizan en la implementación y los efectos de prácticas internas de I+D+i, actividades de I+D+i desarrolladas en colaboración con agentes externos y prácticas de innovación organizativa. A tal efecto, la tesis adopta una perspectiva holística que abarca la complejidad de estos procesos de innovación y la naturaleza diversa de las contingencias que pueden afectarlos. De esta forma, la investigación se ha desarrollado a través de métodos cualitativos y cuantitativos. Así, el estudio de casos llevado a cabo en una primera etapa contribuye a la formulación de las preguntas de investigación de la segunda fase, cuyo análisis se desarrolla a través de la estimación de modelos causales y basa la interpretación de los resultados en el cálculo de efectos marginales. Las conclusiones del primer estudio cualitativo subrayan la importancia de la innovación organizativa para la generación de valor en las empresas, y sugieren que ésta favorece la explotación de los resultados de las prácticas de innovación tecnológica. El tercer estudio testea estas conclusiones a través de un análisis cuantitativo, y presenta evidencia de la existencia de efectos complementarios entre la adopción de prácticas de innovación tecnológica (tanto internas como en colaboración) y de innovación organizativa con respecto a la generación de innovaciones complejas (de producto y proceso conjuntamente). El estudio múltiple de casos presentado en el capítulo dos concluye con la propuesta de un marco teórico sobre el efecto de factores contextuales organizativos en el aprovechamiento de prácticas de innovación en colaboración a lo largo del proceso innovador. Con similares objetivos de avanzar en la comprensión del aprovechamiento de este tipo de prácticas, teniendo en cuenta la influencia de decisiones estratégicas y de contingencias internas, el último estudio presenta un análisis cuantitativo sobre los efectos causales en el desempeño innovador de la proximidad tecnológica y de la intensidad de la colaboración en las distintas etapas del proceso. La evidencia hallada sugiere que las empresas deberían intentar colaborar intensamente con socios tecnológicamente próximos, y prestar atención a los mecanismos de protección, especialmente cuando se colabora en las fases tardías del proceso innovador. This research covers a wide range of innovation practices, and intends to advance the understanding of how to better profit from their implementation, taking into account contextual factors and the potential effects of their joint adoption. In particular, the studies presented here delve into the implementation and effects of in-house R&D&I practices, collaborative R&D&I activities developed with the participation of external agents, and organizational innovation practices. In order to do so, the thesis adopts a comprehensive approach that encompasses the complexity of these innovative processes and the diverse range of contingencies affecting them. Therefore, the research is conducted through both qualitative and quantitative methods. Indeed, the case study methodology applied in the first stage of the investigation helps to define and formulate the research questions for the second stage, whose analysis is conducted through the estimation of causal models, and implies an interpretation of the results by means of calculating average marginal effects. The conclusions from the first qualitative study highlight the relevance of the implementation of organizational innovation practices for value generation in firms, suggesting that organizational innovations allow for better exploitation of the results of technological innovation practices. The third study tests these conclusions through a quantitative analysis, providing evidence of the complementary effect of technological (be it internal or collaborative) and organizational innovation practices when pursuing the generation of complex technological innovations (both product and process innovations). The multiple case study presented in chapter two results in the proposal of a theoretical framework on how organizational context factors influence the profiting of collaborative innovation practices along the stages of the process. Also with purposes of better understanding how firms may profit from collaborative innovation practices, taking into account the potential influence of strategic decisions and internal context contingencies, the study described in chapter four presents a quantitative analysis on the causal effects on innovative performance of technological proximity and the intensity of collaboration in different stages of the process. The evidence found here suggests that firms should try to collaborate intensely with technologically proximate partners, and pay attention to proper protection mechanisms, especially when collaborating in the later stages of the innovation process. Programa de Doctorado en Economía, Empresa y Derecho (RD 99/2011) Ekonomiako, Enpresako eta Zuzenbideko Doktoretza Programa (ED 99/2011)
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- 2018
48. Overcoming the Challenge of Producing Large and Flat Nanocellular Polymers: A Study with PMMA
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Martín‐de León, Judith, primary, Bernardo, Victoria, additional, Cimavilla‐Román, Paula, additional, Pérez‐Tamarit, Saúl, additional, and Rodríguez‐Pérez, Miguel Ángel, additional
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- 2019
- Full Text
- View/download PDF
49. Epidemiological trend of hospitalized acute and recurrent hepatitis C in Spain
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Maté-Cano, Irene, primary, Alvaro-Meca, Alejandro, additional, Ryan, Pablo, additional, Diaz, Asuncion, additional, Martínez-Román, Paula, additional, Sánchez-Carrillo, Marta, additional, Resino, Salvador, additional, and Briz, Verónica, additional
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- 2019
- Full Text
- View/download PDF
50. Investimento e financiamento em empresas inovadoras do setor de serviços na Colômbia
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Barona-Zuluaga, Bernardo, Rivera-Godoy, Jorge Alberto, and Garizado-Román, Paula Andrea
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finanças empreendedoras ,finanzas corporativas ,innovación ,financiamento de ativos intangíveis ,P&D+i ,R&D+i ,capital de riesgo ,finanças corporativas ,financiamento combinado ,mezcla de financiación ,innovation ,intangible asset finance ,inovação ,financiación de activos intangibles ,entrepreneurial finance ,corporate finance ,I&D+i ,blended finance ,venture capital ,capital de risco ,finanzas emprendedoras - Abstract
RESUMEN Este artículo busca conocer acerca de las actividades de inversión en I&D+i y su financiación en empresas innovadoras del sector servicios en Colombia; para esto, se realiza un análisis estadístico y econométrico de la información contenida en la Encuesta de Desarrollo e Innovación Tecnológica del Sector Servicios (EDITS III), elaborada por el Departamento Administrativo Nacional de Estadística (DANE). Los resultados muestran que las empresas invierten más en activos tangibles que en intangibles, y se financian en mayor proporción con recursos propios (65%) que con banca privada (18,5%). Además, se halla una asociación negativa significativa entre la inversión en maquinaria y equipo y la financiación con recursos propios. ABSTRACT This article seeks to examine investment activities in R&D+i and their financing in innovative companies of the services sector in Colombia; to this effect, it presents a statistical and econometric analysis of the information contained in the Survey of Development and Technological Innovation in the Services Sector (EDITS III), prepared by the National Administrative Department of Statistics (DANE). The results show that companies invest more in tangible assets than in assets of intangible nature, and are financed in a greater proportion with own resources (65%) than with private banking (18.5%). In addition, there is a significant negative association between investment in machinery and equipment and financing with own resources. RESUMO Este artigo busca conhecer as atividades de investimento em P&D+i e o seu financiamento em empresas inovadoras do setor de serviços na Colômbia; para isso, é realizada uma análise estatística e econométrica da informação contida na Enquete de Desenvolvimento e Inovação Tecnológica do Setor de Serviços (EDITS III), elaborada pelo Departamento Administrativo Nacional de Estatística (Dane). Os resultados mostram que as empresas investem mais em ativos tangíveis que em intangíveis, e são financiadas em maior proporção com recursos próprios (65%) que com banca privada (18,5%). Além disso, foi encontrada uma associação negativa significativa entre o investimento em maquinaria e equipamento e o financiamento com recursos próprios.
- Published
- 2017
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