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1. Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial

Author

Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Dölle-Bierke, Sabine, Roll, Stephanie, Tissen-Diabaté, Tatjana, Lau, Susanne, Forslund, Sofia, Marenholz, Ingo, Lee, Young-Ae, Thiel, Andreas, Babina, Magda, Scheffel, Jörg, Worm, Margitta, and Beyer, Kirsten

Published
2024
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5. Satisfaction with a new patient education program for children, adolescents, and young adults with differences of sex development (DSD) and their parents.

Author

Wiegmann, Sabine, Schilling, Ralph, Winter, Mirja, Ernst, Martina, Wechsung, Katja, Kalender, Ute, Stöckigt, Barbara, Richter-Unruh, Annette, Hiort, Olaf, Döhnert, Ulla, Marshall, Louise, Rohayem, Julia, Liesenkötter, Klaus-Peter, Wabitsch, Martin, Herrmann, Gloria, Ernst, Gundula, Roll, Stephanie, Keil, Thomas, and Neumann, Uta

Published
2024
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8. The KORE-INNOVATION trial, a prospective controlled multi-site clinical study to implement and assess the effects of an innovative peri-operative care pathway for patients with ovarian cancer: rationale, methods and trial design

Author

Inci, Melisa Guelhan, Sehouli, Jalid, Schnura, Eva, Lee, Marlene, Roll, Stephanie, Reinhold, Thomas, Klews, Julia, Kaufner, Lutz, Niggemann, Phil, Groeben, Harald, Toelkes, Julia, Reisshauer, Anett, Liebl, Max, Daehnert, Enrico, Zimmermann, Manuela, Knappe-Drzikova, Barbora, Rolker, Susanne, Nunier, Björn, Algharably, Engi, Pirmorady Sehouli, Adak, Zwantleitner, Lena, Krull, Andrea, Heitz, Florian, Ataseven, Beyhan, Chekerov, Radoslav, Harter, Philipp, and Schneider, Stephanie

Published
2023
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13. Statistical Analysis in the German National Cohort (NAKO) – Specific Aspects and General Recommendations

Author

Kuss, Oliver, Becher, Heiko, Wienke, Andreas, Ittermann, Till, Ostrzinski, Stefan, Schipf, Sabine, Schmidt, Carsten O, Leitzmann, Michael, Pischon, Tobias, Krist, Lilian, Roll, Stephanie, Sand, Matthias, Pohlabeln, Hermann, Rach, Stefan, Jöckel, Karl-Heinz, Stang, Andreas, Mueller, Ulrich A, Werdecker, Andrea, Westerman, Ronny, Greiser, Karin H, and Michels, Karin B

Published
2022
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15. Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Published
2022
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16. Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial

Author

Kalb, Birgit, Meixner, Lara, Trendelenburg, Valérie, Unterleider, Nathalie, Dobbertin-Welsch, Josefine, Heller, Stephanie, Dölle-Bierke, Sabine, Roll, Stephanie, Lau, Susanne, Lee, Young-Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Worm, Margitta, and Beyer, Kirsten

Published
2022
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18. Development and evaluation of a patient education programme for children, adolescents, and young adults with differences of sex development (DSD) and their parents: study protocol of Empower-DSD

Author

Wiegmann, Sabine, Ernst, Martina, Ihme, Loretta, Wechsung, Katja, Kalender, Ute, Stöckigt, Barbara, Richter-Unruh, Annette, Vögler, Sander, Hiort, Olaf, Jürgensen, Martina, Marshall, Louise, Menrath, Ingo, Schneidewind, Julia, Wagner, Isabel, Rohayem, Julia, Liesenkötter, Klaus-Peter, Wabitsch, Martin, Fuchs, Malaika, Herrmann, Gloria, Lutter, Henriette, Ernst, Gundula, Lehmann, Christine, Haase, Martina, Roll, Stephanie, Schilling, Ralph, Keil, Thomas, and Neumann, Uta

Published
2022
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21. Assessment of Psychosocial Stress and Mental Health Disorders in Parents and Their Children in Early Childhood: Cross-Sectional Results from the SKKIPPI Cohort Study.

Author

Fricke, Julia, Bolster, Marie, Icke, Katja, Lisewski, Natalja, Kuchinke, Lars, Ludwig-Körner, Christiane, Schlensog-Schuster, Franziska, Reinhold, Thomas, Berghöfer, Anne, Roll, Stephanie, and Keil, Thomas

Subjects
CROSS-sectional method, RESEARCH funding, MENTAL illness, PARENT-child relationships, STATISTICAL sampling, ANXIETY, DESCRIPTIVE statistics, LONGITUDINAL method, OBSESSIVE-compulsive disorder, PSYCHOLOGICAL stress, CHILD development, PSYCHOLOGY of parents, SOCIAL support, DATA analysis software, ADVERSE childhood experiences, MENTAL depression
Abstract

Background/Objectives: Early childhood can be a stressful period for families with a significant impact on parents' mental health, the child's healthy development, and the development of a secure mother–child attachment. The goal of the cross-sectional study part of SKKIPPI was to assess the occurrence of psychosocial stress and mental health disorders in parents as well as in their offspring in early childhood in three German regions. Methods: Based on random samples from three residents' registration offices, parents with infants aged up to 12 months were invited to participate. An online screening questionnaire was developed in four languages to assess common psychosocial stressors and mental health problems of parents with small children. Results: The study enrolled 4984 mothers and 962 fathers. The most common potential psychosocial stressors were professional problems (mothers 22%, fathers 33%), lack of social support (20%, 14%), and severe, negative experiences in childhood (22%, 16%). Obsessive–compulsive thoughts (21%, 16%) and depressive (9%, 9%) and anxiety symptoms (11%, 7%) were the most frequently reported mental health problems by both parents. Regulatory problems of the child were reported by between 1.5% and 5.1% of parents. Conclusions: The study showed that a substantial proportion of parents are burdened by psychosocial problems and suffer from mental health problems in the first years after the birth of their children. Early preventive and low-threshold support measures should be available in the health and social care system. Low-threshold questionnaires, which cover a wide range of possible stress factors, should be further developed for the practical healthcare of this group of people. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Efficacy of parent-infant psychotherapy compared to care as usual in children with regulatory disorders in clinical and outpatient settings: study protocol of a randomised controlled trial as part of the SKKIPPI project

Author

Sprengeler, Mona Katharina, Mattheß, Janna, Eckert, Melanie, Richter, Katharina, Koch, Gabriele, Reinhold, Thomas, Vienhues, Petra, Berghöfer, Anne, Fricke, Julia, Roll, Stephanie, Keil, Thomas, Ludwig-Körner, Christiane, Kuchinke, Lars, von Klitzing, Kai, and Schlensog-Schuster, Franziska

Published
2021
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27. Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial

Author

Hoerder, Sebastian, primary, Habermann, Isabel Valentina, additional, Hahn, Katrin, additional, Meyer-Hamme, Gesa, additional, Ortiz, Miriam, additional, Grabowska, Weronika, additional, Roll, Stephanie, additional, Willich, Stefan N., additional, Schroeder, Sven, additional, Brinkhaus, Benno, additional, and Dietzel, Joanna, additional

Published
2023
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28. The effectiveness of acupuncture and mindfulness-based stress reduction (MBSR) for patients with multiple sclerosis associated fatigue – A study protocol and its rationale for a randomized controlled trial

Author

Bellmann-Strobl, Judith, Pach, Daniel, Chang, Yinghui, Pasura, Laura, Liu, Bin, Jäger, Sven Florian, Loerch, Ronny, Jin, Li, Blödt, Susanne, Brinkhaus, Benno, Ortiz, Miriam, Reinhold, Thomas, Roll, Stephanie, Binting, Sylvia, Paul, Friedemann, Witt, Claudia M., and Shi, Xuemin

Published
2018
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30. Past attachment experiences, the potential link of mentalization and the transmission of behavior to the child by mothers with mental health problems: cross-sectional analysis of a clinical sample

Author

Mattheß, Janna, primary, Koch, Gabriele, additional, Keil, Thomas, additional, Roll, Stephanie, additional, Berghöfer, Anne, additional, Ludwig-Körner, Christiane, additional, Schlensog-Schuster, Franziska, additional, Sprengeler, Mona Katharina, additional, von Klitzing, Kai, additional, and Kuchinke, Lars, additional

Published
2023
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31. #965 First impressions of patients‘ perspectives of prehabilitation as part of the kore-innovation trial: the first prospective clinical trial to assess a perioperative pathway to reduce postoperative complications in ovarian cancer

Author

Lee, Marlene Misu, primary, Sehouli, Jalid, additional, Inci-Turan, Melisa Guelhan, additional, Schnura, Eva, additional, Harter, Philipp, additional, Chekerov, Radoslav, additional, Klews, Julia, additional, Roll, Stephanie, additional, Willich, Stefan, additional, Brinkmann, Marlen, additional, Niggemann, Phil, additional, Meinert, Fabian Maximilian, additional, Pirmorady-Sehouli, Adak, additional, Reinhold, Thomas, additional, Zimmermann, Manuela, additional, Thorau, Henriette, additional, Runge, Aleksander, additional, Zwanzleitner, Lena, additional, Krull, Andrea, additional, and Schneider, Stephanie, additional

Published
2023
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34. Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Author

Radauer-Plank, Anne-Catherine, Diesch-Furlanetto, Tamara, Schneider, Monika, Sommerhäuser, Greta, Friedrich, Lucía Alácan, Salow, Vivienne, Dülberg, Jill, Diepold, Miriam, Rovó, Alicia, Njue, Linet Muthoni, Drexler, Beatrice, Infanti, Laura, Kroiss, Sabine, Merki, Ramona, Scheinemann, Katrin, Eisenreich, Bernhard, Hegemann, Inga, Mandic, Ljubica, Kager, Leo, Borgmann-Staudt, Anja, Schilling, Ralph, Roll, Stephanie, and Balcerek, Magdalena

Subjects
Oncology, Pediatrics, Perinatology and Child Health, 610 Medicine & health, Hematology
Abstract

BACKGROUND Both diagnosis and treatment of hemoglobinopathies have been associated with an increased risk of fertility impairment. German guidelines recommend annual monitoring of fertility parameters to enable early detection of fertility impairment and/or to offer fertility preservation (FP) when indicated. We explored the general desire for parenthood, the frequency of recalling fertility counseling and testing, and the utilization of FP in adolescents and adults with hemoglobinopathies. PROCEDURE In a cross-sectional study, patients aged 12-50 years, treated in Germany, Austria, or Switzerland, were surveyed on fertility-related aspects. Medical data, including fertility testing results, were collected from patient records. RESULTS Overall, 116/121 eligible patients, diagnosed with sickle cell disease (70.7%), thalassemia (27.6%), or other hemoglobinopathy (1.7%), participated in our study (57.8% female, median age 17.0 years, range 12-50 years). All participants required treatment of the underlying hemoglobinopathy: 68.1% received hydroxyurea, 25.9% required regular blood transfusions, and 6.0% underwent hematopoietic stem cell transplantation (HSCT). Most patients (82/108, 75.9%) stated a considerable to strong desire for (future) parenthood, independent of sex, education, diagnosis, or subjective health status. Fertility counseling was only recalled by 32/111 patients (28.8%) and least frequently by younger patients (12-16 years) or those treated with regular blood transfusions or hydroxyurea. While fertility testing was documented for 59.5% (69/116) in medical records, only 11.6% (13/112) recalled previous assessments. FP was only used by 5.4% (6/111) of patients. CONCLUSION Most patients with hemoglobinopathies wish to have biological children, yet only few recalled fertility counseling and testing. Adequate patient counseling should be offered to all patients at risk for infertility.

Published
2023
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38. Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Author

Radauer-Plank, Anne-Catherine; https://orcid.org/0009-0003-1535-4709, Diesch-Furlanetto, Tamara, Schneider, Monika, Sommerhäuser, Greta, Friedrich, Lucía Alácan, Salow, Vivienne, Dülberg, Jill, Diepold, Miriam, Rovó, Alicia, Njue, Linet Muthoni, Drexler, Beatrice, Infanti, Laura, Kroiss, Sabine, Merki, Ramona, Scheinemann, Katrin; https://orcid.org/0000-0002-3578-7152, Eisenreich, Bernhard, Hegemann, Inga, Mandic, Ljubica, Kager, Leo, Borgmann-Staudt, Anja, Schilling, Ralph, Roll, Stephanie; https://orcid.org/0000-0003-1191-3289, Balcerek, Magdalena, Radauer-Plank, Anne-Catherine; https://orcid.org/0009-0003-1535-4709, Diesch-Furlanetto, Tamara, Schneider, Monika, Sommerhäuser, Greta, Friedrich, Lucía Alácan, Salow, Vivienne, Dülberg, Jill, Diepold, Miriam, Rovó, Alicia, Njue, Linet Muthoni, Drexler, Beatrice, Infanti, Laura, Kroiss, Sabine, Merki, Ramona, Scheinemann, Katrin; https://orcid.org/0000-0002-3578-7152, Eisenreich, Bernhard, Hegemann, Inga, Mandic, Ljubica, Kager, Leo, Borgmann-Staudt, Anja, Schilling, Ralph, Roll, Stephanie; https://orcid.org/0000-0003-1191-3289, and Balcerek, Magdalena

Abstract

BACKGROUND Both diagnosis and treatment of hemoglobinopathies have been associated with an increased risk of fertility impairment. German guidelines recommend annual monitoring of fertility parameters to enable early detection of fertility impairment and/or to offer fertility preservation (FP) when indicated. We explored the general desire for parenthood, the frequency of recalling fertility counseling and testing, and the utilization of FP in adolescents and adults with hemoglobinopathies. PROCEDURE In a cross-sectional study, patients aged 12-50 years, treated in Germany, Austria, or Switzerland, were surveyed on fertility-related aspects. Medical data, including fertility testing results, were collected from patient records. RESULTS Overall, 116/121 eligible patients, diagnosed with sickle cell disease (70.7%), thalassemia (27.6%), or other hemoglobinopathy (1.7%), participated in our study (57.8% female, median age 17.0 years, range 12-50 years). All participants required treatment of the underlying hemoglobinopathy: 68.1% received hydroxyurea, 25.9% required regular blood transfusions, and 6.0% underwent hematopoietic stem cell transplantation (HSCT). Most patients (82/108, 75.9%) stated a considerable to strong desire for (future) parenthood, independent of sex, education, diagnosis, or subjective health status. Fertility counseling was only recalled by 32/111 patients (28.8%) and least frequently by younger patients (12-16 years) or those treated with regular blood transfusions or hydroxyurea. While fertility testing was documented for 59.5% (69/116) in medical records, only 11.6% (13/112) recalled previous assessments. FP was only used by 5.4% (6/111) of patients. CONCLUSION Most patients with hemoglobinopathies wish to have biological children, yet only few recalled fertility counseling and testing. Adequate patient counseling should be offered to all patients at risk for infertility.

Published
2023

39. Acupuncture in chemotherapy-induced dysgeusia (AcuDysg): study protocol of a randomised controlled trial

Author

Huber, Christine; https://orcid.org/0000-0002-0009-9296, Zhang, Linxin; https://orcid.org/0000-0003-4612-460X, Schlaeppi, Marc, Müller, Twyla; https://orcid.org/0000-0003-1037-5714, Roll, Stephanie; https://orcid.org/0000-0003-1191-3289, Voiss, Petra; https://orcid.org/0000-0002-9005-0479, Barth, Jürgen; https://orcid.org/0000-0001-7096-7178, Driessen, Christoph, Witt, Claudia M; https://orcid.org/0000-0002-5440-7805, Huber, Christine; https://orcid.org/0000-0002-0009-9296, Zhang, Linxin; https://orcid.org/0000-0003-4612-460X, Schlaeppi, Marc, Müller, Twyla; https://orcid.org/0000-0003-1037-5714, Roll, Stephanie; https://orcid.org/0000-0003-1191-3289, Voiss, Petra; https://orcid.org/0000-0002-9005-0479, Barth, Jürgen; https://orcid.org/0000-0001-7096-7178, Driessen, Christoph, and Witt, Claudia M; https://orcid.org/0000-0002-5440-7805

Abstract

Introduction: Dysgeusia is a common side effect of chemotherapy in patients with cancer, but to date, there is no effective treatment. Many patients with cancer request complementary medicine treatment in addition to their cancer treatments, and acupuncture is highly accepted for patients with cancer; however, evidence regarding the effectiveness of acupuncture for dysgeusia is scarce.The study investigates the effectiveness of an additional dysgeusia-specific acupuncture plus self-acupressure intervention compared with supportive acupuncture plus self-acupressure intervention alone for chemotherapy-induced dysgeusia in patients with cancer. Methods and analysis: This is a multicentre, randomised, controlled and two-armed parallel-group, single-blind trial involving 130 patients. Both groups will receive eight sessions of acupuncture treatment over a period of 8 weeks and will be trained to perform self-acupressure (eLearning combined with therapist instruction) at predefined acupressure points once a day during the whole treatment period. Patients in the control group will receive supportive routine care acupuncture and self-acupressure treatment only; in addition to this treatment, the intervention group will receive the dysgeusia-specific acupuncture and acupressure within the same treatment session. The primary outcome is the perceived dysgeusia over 8 weeks, measured weekly after the acupuncture treatment. Secondary outcomes include the indices from the objective taste and smell test, weight loss, perceived dysgeusia, fatigue, distress, nausea and vomiting, odynophagia, xerostomia and polyneuropathy, as well as quality of life at the different time points. Ethics and dissemination: The study has been approved by the Cantonal Ethics Committee (CEC) (Kanton Zürich Kantonale Ethikkommission) (approval no. KEK-ZH-Nr. 2020-01900). The results will be submitted to a peer-reviewed journal for publication.

Published
2023

40. Being an Infant in a Pandemic: Influences of the COVID-19 Pandemic on Infants, Toddlers and Their Mothers in a Clinical Population.

Author

Sprengeler, Mona Katharina, Mattheß, Janna, Galeris, Mirijam-Griseldis, Eckert, Melanie, Koch, Gabriele, Reinhold, Thomas, Berghöfer, Anne, Fricke, Julia, Roll, Stephanie, Keil, Thomas, Ludwig-Körner, Christiane, Kuchinke, Lars, von Klitzing, Kai, White, Lars Otto, and Schlensog-Schuster, Franziska

Subjects
MENTAL health, T-test (Statistics), RESEARCH funding, INTERVIEWING, DESCRIPTIVE statistics, CHI-squared test, ANXIETY, PSYCHOLOGY of mothers, RESEARCH methodology, STATISTICS, PANIC disorders, MOTHER-child relationship, DATA analysis software, COMPARATIVE studies, COVID-19 pandemic, CHILDREN
Abstract

The COVID-19 pandemic and the ongoing lockdowns might have had a strong impact on mental health of mothers and their infants/toddlers. For example, families had to deal with health issues and social isolation, which might have affected mental health and parent-child interactions. The aim of this study is to evaluate differences in (1) infantile regulatory disorders, (2) maternal mental health, (3) the impact of maternal mental health on infantile regulatory disorders, and (4) alterations in the mother-child interaction for participants recruited before versus after the onset of the first German lockdown. For this reason, mother-child dyads have been divided into two groups and were compared by analyzing clinical interviews on psychopathology of mother and child (M.I.N.I. & DC:05) and mother-child-interactions (Emotional Availability Scales). Results showed that (1) differences in infantile sleeping disorders emerged (phi = 0.243; p = 0.016) compared to the pre-lockdown group, while (2) the occurrence of maternal panic and anxiety increased in the post-lockdown group (phi = 0.229; p = 0.022). Moreover, there was (3) an association for maternal panic and child's sleep disorder, and (4) specific associations with maternal non-hostility in the mother-child-interaction. In conclusion, the present study highlights the differences of maternal mental health occurrences and infants' regulatory problems, as well as the possible effects of the COVID-19 pandemic for infants. In the pre-lockdown group, maternal non-hostility might have acted as a promotive factor against regulatory disorders, while this mechanism was mitigated in the post-lockdown group. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Author

Radauer‐Plank, Anne‐Catherine, primary, Diesch‐Furlanetto, Tamara, additional, Schneider, Monika, additional, Sommerhäuser, Greta, additional, Friedrich, Lucía Alácan, additional, Salow, Vivienne, additional, Dülberg, Jill, additional, Diepold, Miriam, additional, Rovó, Alicia, additional, Njue, Linet Muthoni, additional, Drexler, Beatrice, additional, Infanti, Laura, additional, Kroiss, Sabine, additional, Merki, Ramona, additional, Scheinemann, Katrin, additional, Eisenreich, Bernhard, additional, Hegemann, Inga, additional, Mandic, Ljubica, additional, Kager, Leo, additional, Borgmann‐Staudt, Anja, additional, Schilling, Ralph, additional, Roll, Stephanie, additional, and Balcerek, Magdalena, additional

Published
2023
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42. Acupuncture in Patients with Diabetic Peripheral Neuropathy-Related Complaints: A Randomized Controlled Clinical Trial

Author

Dietzel, Joanna, primary, Habermann, Isabel V., additional, Hörder, Sebastian, additional, Hahn, Katrin, additional, Meyer-Hamme, Gesa, additional, Ortiz, Miriam, additional, Hua, Kevin, additional, Stöckigt, Barbara, additional, Bolster, Marie, additional, Grabowska, Weronika, additional, Roll, Stephanie, additional, Binting, Sylvia, additional, Willich, Stefan N., additional, Schröder, Sven, additional, and Brinkhaus, Benno, additional

Published
2023
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45. Acupuncture and osteopathic medicine for atopic dermatitis: a three-armed, randomized controlled explorative clinical trial

Author

Rotter, Gabriele, primary, Ahnert, Moritz W., additional, Geue, Anne V., additional, Icke, Katja, additional, Binting, Sylvia, additional, Tissen-Diabaté, Tatjana, additional, Roll, Stephanie, additional, Ortiz, Miriam, additional, Reinhold, Thomas, additional, Kass, Benjamin, additional, Staab, Doris, additional, Pfab, Florian, additional, Willich, Stefan N., additional, and Brinkhaus, Benno, additional

Published
2022
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46. Hypnotherapy, Intermittent Fasting, and Exercise Group Programs in Atopic Dermatitis: A Randomized Controlled Explorative Clinical Trial During the COVID-19 Pandemic

Author

Rotter, Gabriele, primary, Teut, Michael, additional, Schleicher, Romy, additional, Dell'Oro, Melanie, additional, Ortiz, Miriam, additional, Binting, Sylvia, additional, Tissen-Diabaté, Tatjana, additional, Roll, Stephanie, additional, Michalsen, Andreas, additional, Staab, Doris, additional, Wolfarth, Bernd, additional, and Brinkhaus, Benno, additional

Published
2022
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48. An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

Author

Worm, Margitta M., Alexiou, Aikaterina, Höfer, Veronika, Birkner, Till, Jeanrenaud, Alexander C.S.N., Fauchère, Florent, Pažur, Kristijan, Steinert, Carolin, Arnau-Soler, Aleix, Banerjee, Priyanka, Diefenbach, Andreas, Dobbertin-Welsch, Josefine, Dölle-Bierke, Sabine, Francuzik, W., Ghauri, Ahla, Heller, Stephanie, Kalb, Birgit, Löber, Ulrike, Marenholz, Ingo, Markó, Lajos, Scheffel, Jörg, Potapenko, Olena, Roll, Stephanie, Lau, Susanne, Lee, Young-ae, Braun, Julian, Thiel, Andreas, Babina, Magda, Altrichter, Sabine, Forslund, Sofia Kirke, Beyer, Kirsten, and Publica

Subjects
food allergy, epigenetics, Cardiovascular and Metabolic Diseases, biomarker, microbiome, peanut allergy
Abstract

Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. Methods: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.

Published
2022

49. Determinanten und Kosten der Inanspruchnahme von Gesundheitsleistungen bei psychosozial belasteten Müttern in der Postpartalphase - erste gesundheitsökonomische Ergebnisse aus der Kohortenstudie des SKKIPPI-Projekts

Author

Kaß, Benjamin, Heinrich-Rohr, Michaela, Lisewski, Natalja, Icke, Katja, Roll, Stephanie, Fricke, Julia, Bolster, Marie, Keil, Thomas, Ludwig-Körner, Christiane, Schlensog-Schuster, Franziska, Kuchinke, Lars, Berghöfer, Anne, and Reinhold, Thomas

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund und Stand (inter)nationaler Forschung: Der Zeitraum nach der Geburt birgt für Mütter und Säuglinge besondere psychosoziale Belastungen. In Deutschland liegen nur begrenzte Erkenntnisse zur Inanspruchnahme von Gesundheitsleistungen und deren Determinanten für diese Lebensphase [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022

50. Controlled non‐randomised before–after study evaluating the impact of a focused recommendation card on vaccination rates of oncological patients—The Easy Vaccination in Oncology (EVO) strategy

Author

Kiderlen, Til R., primary, Trostdorf, Katrin, additional, Delmastro, Nicola, additional, Salomon, Arne, additional, Scholz, Christian W., additional, Späth‐Schwalbe, Ernst, additional, Mansmann, Veit, additional, Roll, Stephanie, additional, Reinwald, Mark, additional, and de Wit, Maike, additional

Published
2022
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