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3. Multimodal workflows optimally predict response to repetitive transcranial magnetic stimulation in patients with schizophrenia: a multisite machine learning analysis

Author

Dong, Mark Sen, Rokicki, Jaroslav, Dwyer, Dominic, Papiol, Sergi, Streit, Fabian, Rietschel, Marcella, Wobrock, Thomas, Müller-Myhsok, Bertram, Falkai, Peter, Westlye, Lars Tjelta, Andreassen, Ole A., Palaniyappan, Lena, Schneider-Axmann, Thomas, Hasan, Alkomiet, Schwarz, Emanuel, and Koutsouleris, Nikolaos

Published
2024
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4. An evolutionary timeline of the oxytocin signaling pathway

Author

Sartorius, Alina M., Rokicki, Jaroslav, Birkeland, Siri, Bettella, Francesco, Barth, Claudia, de Lange, Ann-Marie G., Haram, Marit, Shadrin, Alexey, Winterton, Adriano, Steen, Nils Eiel, Schwarz, Emanuel, Stein, Dan J., Andreassen, Ole A., van der Meer, Dennis, Westlye, Lars T., Theofanopoulou, Constantina, and Quintana, Daniel S.

Published
2024
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6. Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy

Author

Hjell, Gabriela, Rokicki, Jaroslav, Szabo, Attila, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Djurovic, Srdjan, Ueland, Thor, Andreassen, Ole Andreas, Melle, Ingrid, Lagerberg, Trine Vik, Mørch-Johnsen, Lynn, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2023
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8. The genetic architecture of human cortical folding

Author

van der Meer, Dennis, Kaufmann, Tobias, Shadrin, Alexey A, Makowski, Carolina, Frei, Oleksandr, Roelfs, Daniel, Monereo-Sánchez, Jennifer, Linden, David EJ, Rokicki, Jaroslav, Alnæs, Dag, de Leeuw, Christiaan, Thompson, Wesley K, Loughnan, Robert, Fan, Chun Chieh, Westlye, Lars T, Andreassen, Ole A, and Dale, Anders M

Subjects
Genetics, Brain Disorders, Human Genome, Neurosciences
Abstract

The folding of the human cerebral cortex is a highly genetically regulated process that allows for a much larger surface area to fit into the cranial vault and optimizes functional organization. Sulcal depth is a robust yet understudied measure of localized folding, previously associated with multiple neurodevelopmental disorders. Here, we report the first genome-wide association study of sulcal depth. Through the multivariate omnibus statistical test (MOSTest) applied to vertex-wise measures from 33,748 U.K. Biobank participants (mean age, 64.3 years; 52.0% female), we identified 856 genome-wide significant loci (P < 5 × 10−8). Comparisons with cortical thickness and surface area indicated that sulcal depth has higher locus yield, heritability, and effective sample size. There was a large amount of genetic overlap between these traits, with gene-based analyses indicating strong associations with neurodevelopmental processes. Our findings demonstrate sulcal depth is a promising neuroimaging phenotype that may enhance our understanding of cortical morphology.

Published
2021

11. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M, Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K, Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L, Buitelaar, Jan, Celius, Elisabeth G, Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M, de Quervain, Dominique JF, Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S, Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K, Harbo, Hanne F, Hartman, Catharina A, Heslenfeld, Dirk, Hoekstra, Pieter J, Høgestøl, Einar A, Jernigan, Terry L, Jonassen, Rune, Jönsson, Erik G, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J, Maglanoc, Luigi A, Malt, Ulrik F, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B, Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbæk, Geir, Shadrin, Alexey A, Smeland, Olav B, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M, Tsolaki, Magda, Ulrichsen, Kristine M, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C, Zink, Mathias, Andreassen, Ole A, and Westlye, Lars T

Subjects
Biological Psychology, Psychology, Rare Diseases, Mental Health, Neurosciences, Brain Disorders, Biomedical Imaging, Aging, Aetiology, 2.3 Psychological, social and economic factors, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Neurological, Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Brain, Brain Diseases, Child, Child, Preschool, Female, Genome-Wide Association Study, Humans, Infant, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuropsychological Tests, Schizophrenia, Sex Characteristics, Young Adult, Karolinska Schizophrenia Project, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Published
2019

16. Genetic control of variability in subcortical and intracranial volumes

Author

Córdova-Palomera, Aldo, van der Meer, Dennis, Kaufmann, Tobias, Bettella, Francesco, Wang, Yunpeng, Alnæs, Dag, Doan, Nhat Trung, Agartz, Ingrid, Bertolino, Alessandro, Buitelaar, Jan K., Coynel, David, Djurovic, Srdjan, Dørum, Erlend S., Espeseth, Thomas, Fazio, Leonardo, Franke, Barbara, Frei, Oleksandr, Håberg, Asta, Le Hellard, Stephanie, Jönsson, Erik G., Kolskår, Knut K., Lund, Martina J., Moberget, Torgeir, Nordvik, Jan E., Nyberg, Lars, Papassotiropoulos, Andreas, Pergola, Giulio, de Quervain, Dominique, Rampino, Antonio, Richard, Genevieve, Rokicki, Jaroslav, Sanders, Anne-Marthe, Schwarz, Emanuel, Smeland, Olav B., Steen, Vidar M., Starrfelt, Jostein, Sønderby, Ida E., Ulrichsen, Kristine M., Andreassen, Ole A., and Westlye, Lars T.

Published
2021
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18. Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study

Author

Farde, L., Flyckt, L., Engberg, G., Erhardt, S., Fatouros-Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Agartz, I., Collste, K., Victorsson, P., Malmqvist, A., Hedberg, M., Orhan, F., Sellgren, C., Tønnesen, Siren, Kaufmann, Tobias, de Lange, Ann-Marie G., Richard, Geneviève, Doan, Nhat Trung, Alnæs, Dag, van der Meer, Dennis, Rokicki, Jaroslav, Moberget, Torgeir, Maximov, Ivan I., Agartz, Ingrid, Aminoff, Sofie R., Beck, Dani, Barch, Deanna M., Beresniewicz, Justyna, Cervenka, Simon, Fatouros-Bergman, Helena, Craven, Alexander R., Flyckt, Lena, Gurholt, Tiril P., Haukvik, Unn K., Hugdahl, Kenneth, Johnsen, Erik, Jönsson, Erik G., Kolskår, Knut K., Kroken, Rune Andreas, Lagerberg, Trine V., Løberg, Else-Marie, Nordvik, Jan Egil, Sanders, Anne-Marthe, Ulrichsen, Kristine, Andreassen, Ole A., and Westlye, Lars T.

Published
2020
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19. Parental education and income are linked to offspring cortical brain structure and psychopathology at 9–11 years

Author

Norbom, Linn B., primary, Rokicki, Jaroslav, additional, Eilertsen, Espen M., additional, Wiker, Thea, additional, Hanson, Jamie, additional, Dahl, Andreas, additional, Alnæs, Dag, additional, Fernández‐Cabello, Sara, additional, Beck, Dani, additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, and Tamnes, Christian K., additional

Published
2024
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20. Regional Genetic Architecture of the Corpus Callosum and its Overlap with Psychiatric and Substance Use Phenotypes

Author

Campbell, Megan L, primary, Shadrin, Alexey, additional, van der Meer, Dennisa, additional, Tesfaye, Markos, additional, Smeland, Olav Bjerkehagen, additional, O'Connell, Kevin S, additional, Parker, Nadine, additional, Frei, Oleksandr, additional, Andreassen, Ole, additional, Stein, Dan, additional, Dalvie, Shareefa, additional, and Rokicki, Jaroslav, additional

Published
2023
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24. Violent Offending in Males With or Without Schizophrenia: A Role for Social Cognition?

Author

Vaskinn, Anja, Rokicki, Jaroslav, Bell, Christina, Tesli, Natalia, Bang, Nina, Hjell, Gabriela, Fischer-Vieler, Thomas, Haukvik, Unn K, and Friestad, Christine

Subjects
CRIME statistics, VIOLENCE, RESEARCH funding, CRIMINALS, KRUSKAL-Wallis Test, SCHIZOPHRENIA, SOCIAL perception, AFFECTIVE disorders, DESCRIPTIVE statistics, AGGRESSION (Psychology), COGNITION disorders, STATISTICS, ANALYSIS of variance, THOUGHT & thinking
Abstract

Background and Hypothesis Reduced social cognition has been reported in individuals who have committed interpersonal violence. It is unclear if individuals with schizophrenia and a history of violence have larger impairments than violent individuals without psychosis and non-violent individuals with schizophrenia. We examined social cognition in two groups with violent offenses, comparing their performance to non-violent individuals with schizophrenia and healthy controls. Study Design Two social cognitive domains were assessed in four groups: men with a schizophrenia spectrum disorder with (SSD-V, n  = 27) or without (SSD-NV, n  = 42) a history of violence, incarcerated men serving preventive detention sentences (V, n  = 22), and healthy male controls (HC, n  = 76). Theory of mind (ToM) was measured with the Movie for the Assessment of Social Cognition (MASC), body emotion perception with Emotion in Biological Motion (EmoBio) test. Study Results Kruskal–Wallis H -tests revealed overall group differences for social cognition. SSD-V had a global and clinically significant social cognitive impairment. V had a specific impairment, for ToM. Binary logistic regressions predicting violence category membership from social cognition and psychosis (SSD status) were conducted. The model with best fit, explaining 18%–25% of the variance, had ToM as the only predictor. Conclusions Social cognitive impairment was present in individuals with a history of violence, with larger and more widespread impairment seen in schizophrenia. ToM predicted violence category membership, psychosis did not. The results suggest a role for social cognition in understanding interpersonal violence. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation.

Author

van der Meer, Dennis, Cheng, Weiqiu, Rokicki, Jaroslav, Fernandez-Cabello, Sara, Shadrin, Alexey, Smeland, Olav B, Ehrhart, Friederike, Gülöksüz, Sinan, Pries, Lotta-Katrin, Lin, Bochao, Rutten, Bart P F, Os, Jim van, O'Donovan, Michael, Richards, Alexander L, Steen, Nils Eiel, Djurovic, Srdjan, Westlye, Lars T, Andreassen, Ole A, Kaufmann, Tobias, and (GROUP), Genetic Risk and Outcome of Psychosis investigators

Subjects
GENETICS of schizophrenia, RISK assessment, CLUSTER analysis (Statistics), RESEARCH funding, FUNCTIONAL assessment, NEURAL development, BRAIN, TRANSCRIPTION factors, CELL cycle, IMMUNE system, GENE expression
Abstract

Background Schizophrenia is a highly heritable brain disorder with a typical symptom onset in early adulthood. The 2-hit hypothesis posits that schizophrenia results from differential early neurodevelopment, predisposing an individual, followed by a disruption of later brain maturational processes that trigger the onset of symptoms. Study design We applied hierarchical clustering to transcription levels of 345 genes previously linked to schizophrenia, derived from cortical tissue samples from 56 donors across the lifespan. We subsequently calculated clustered-specific polygenic risk scores for 743 individuals with schizophrenia and 743 sex- and age-matched healthy controls. Study results Clustering revealed a set of 183 genes that was significantly upregulated prenatally and downregulated postnatally and 162 genes that showed the opposite pattern. The prenatally upregulated set of genes was functionally annotated to fundamental cell cycle processes, while the postnatally upregulated set was associated with the immune system and neuronal communication. We found an interaction between the 2 scores; higher prenatal polygenic risk showed a stronger association with schizophrenia diagnosis at higher levels of postnatal polygenic risk. Importantly, this finding was replicated in an independent clinical cohort of 3233 individuals. Conclusions We provide genetics-based evidence that schizophrenia is shaped by disruptions of separable biological processes acting at distinct phases of neurodevelopment. The modeling of genetic risk factors that moderate each other's effect, informed by the timing of their expression, will aid in a better understanding of the development of schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Conduct disorder - a comprehensive exploration of comorbidity patterns, genetic and environmental risk factors

Author

Tesli, Natalia, primary, Jaholkowski, Piotr, additional, Haukvik, Unn K, additional, Jangmo, Andreas, additional, Haram, Marit, additional, Rokicki, Jaroslav, additional, Friestad, Christine, additional, Tielbeek, Jorim J, additional, Næss, Øyvind, additional, Skardhamar, Torbjørn, additional, Gustavson, Kristin, additional, Ask, Helga, additional, Fazel, Seena, additional, Tesli, Martin, additional, and Andreassen, Ole A, additional

Published
2023
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27. Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy

Author

Haukvik, Unn K, primary, Wolfers, Thomas, additional, Tesli, Natalia, additional, Bell, Christina, additional, Hjell, Gabriela, additional, Fischer-Vieler, Thomas, additional, Bang, Nina, additional, Melle, Ingrid, additional, Andreassen, Ole A, additional, Rasmussen, Kirsten, additional, Agartz, Ingrid, additional, Westlye, Lars T, additional, Friestad, Christine, additional, and Rokicki, Jaroslav, additional

Published
2023
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30. Psychopathy subdomains in violent offenders with and without a psychotic disorder

Author

Bell, Christina, Tesli, Natalia, Gurholt, Tiril Pedersen, Rokicki, Jaroslav, Hjell, Gabriela, Fischer-Vieler, Thomas, Melle, Ingrid, Agartz, Ingrid, Andreassen, Ole, Ringen, Petter Andreas, Rasmussen, Kirsten, Dahl, Hilde, Friestad, Christine, and Haukvik, Unn Kristin Hansen

Subjects
Genetics & Heredity, Science & Technology, NECROSIS-FACTOR-ALPHA, VARIANTS, AMYLOID-BETA, RISK LOCI, Psychiatry and Mental health, PREDICTION MODELS, IMPUTATION, GENOME-WIDE ASSOCIATION, Life Sciences & Biomedicine, METAANALYSIS, GENERATION, RESPONSES
Abstract

Background Violence in psychosis has been linked to antisocial behavior and psychopathy traits. Psychopathy comprises aspects of interpersonal, affective, lifestyle, and antisocial traits which may be differently involved in violent offending by persons with psychotic disorders. We explored psychopathy subdomains among violent offenders with and without a psychotic disorder. Methods 46 males, with a history of severe violence, with (n = 26; age 35.85 ± 10.34 years) or without (n = 20; age 39.10 ± 11.63 years) a diagnosis of a psychotic disorder, were assessed with the Psychopathy Checklist-Revised (PCL-R). PCL-R was split into subdomains following the four-facet model. Group differences in total and subdomain scores were analyzed with a general linear model with covariates. Results Total PCL-R scores did not differ between the groups (p = 0.61, Cohen’s d = 0.17). The violent offenders without psychotic disorders had higher facet 2 scores than the patient group with psychotic disorders (p = 0.029, Cohen’s d = 0.77). Facet 1, 3, or 4 scores did not differ between the groups. Controlling for age did not alter the results. Conclusion Patients with a psychotic disorder and a history of severe violence have lower affective psychopathy scores than violent offenders without psychotic disorders. This observation may point toward distinct underlying mechanisms for violence and may provide a target for focused treatment and prevention.

Published
2022

33. 244. Interindividual Brain Morphology Deviations From Normative Trajectories in Psychopathy, Psychosis, and Violence

Author

Rokicki, Jaroslav, primary, Wolfers, Thomas, additional, Tesli, Natalia, additional, Bell, Christina, additional, Hjell, Gabriela, additional, Fisher-Vieler, Thomas, additional, Melle, Ingrid, additional, Andreassen, Ole, additional, Rasmussen, Kirsten, additional, Agartz, Ingrid, additional, Westlye, Lars T., additional, Friestad, Christine, additional, and Haukvik, Unn, additional

Published
2023
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34. 30. Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation

Author

van der Meer, Dennis, primary, Cheng, Weiqiu, additional, Rokicki, Jaroslav, additional, Rodriguez-Cabello, Sara F., additional, Shadrin, Alexey, additional, Smeland, Olav, additional, Ehrhart, Friederike, additional, Guloksuz, Sinan, additional, Pries, Lotta-Katrin, additional, Lin, Bochao, additional, Rutten, Bart, additional, van Os, Jim, additional, Steen, Nils Eiel, additional, Djurovic, Srdjan, additional, Westlye, Lars, additional, Andreassen, Ole, additional, and Kaufmann, Tobias, additional

Published
2023
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35. Associations between everyday activities and arterial spin labeling‐derived cerebral blood flow: A longitudinal study in community‐dwelling elderly volunteers

Author

Sanders, Anne‐Marthe, primary, Richard, Geneviève, additional, Kolskår, Knut, additional, Ulrichsen, Kristine M., additional, Alnæs, Dag, additional, Beck, Dani, additional, Dørum, Erlend S., additional, Engvig, Andreas, additional, Lund, Martina Jonette, additional, Nordhøy, Wibeke, additional, Pedersen, Mads L., additional, Rokicki, Jaroslav, additional, Nordvik, Jan Egil, additional, and Westlye, Lars T., additional

Published
2023
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37. Parental education and income are linked to offspring cortical brain structure and psychopathology at 9-11 years

Author

Norbom, Linn B., primary, Rokicki, Jaroslav, additional, Eilertsen, Espen M., additional, Wiker, Thea, additional, Hanson, Jamie, additional, Dahl, Andreas, additional, Alnæs, Dag, additional, Fernández-Cabello, Sara, additional, Beck, Dani, additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, and Tamnes, Christian K., additional

Published
2023
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40. An evolutionary timeline of the oxytocin signaling pathway

Author

Sartorius, Alina M., primary, Rokicki, Jaroslav, additional, Bettella, Francesco, additional, barth, claudia, additional, de Lange, Ann-Marie G, additional, Haram, Marit, additional, Shadrin, Alexey, additional, Winterton, Adriano, additional, Steen, Nils Eiel, additional, Emanuel, Schwarz, additional, Stein, Dan J., additional, Andreassen, Ole A., additional, van der Meer, Dennis, additional, Westlye, Lars T., additional, Theofanopoulou, Constantina, additional, and Quintana, Daniel S, additional

Published
2022
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43. Associations between everyday activities and arterial spin labelling-derived cerebral blood flow: A longitudinal study in community-dwelling elderly volunteers

Author

Sanders, Anne-Marthe, primary, Richard, Geneviève, additional, Kolskår, Knut, additional, Ulrichsen, Kristine M., additional, Alnæs, Dag, additional, Beck, Dani, additional, Dørum, Erlend S., additional, Engvig, Andreas, additional, Lund, Martina Jonette, additional, Nordhøy, Wibeke, additional, Pedersen, Mads L., additional, Rokicki, Jaroslav, additional, Nordvik, Jan Egil, additional, and Westlye, Lars T., additional

Published
2022
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49. Clustering schizophrenia genes by their temporal expression patterns aids functional interpretation genetics-based evidence in favor of the two-hit hypothesis

Author

van der Meer, Dennis, primary, Cheng, Weiqiu, additional, Rokicki, Jaroslav, additional, Fernandez-Cabello, Sara, additional, Shadrin, Alexey, additional, Smeland, Olav B., additional, Ehrhart, Friederike, additional, Gülöksüz, Sinan, additional, Steen, Nils Eiel, additional, Djurovic, Srdjan, additional, Westlye, Lars T., additional, Andreassen, Ole A., additional, and Kaufmann, Tobias, additional

Published
2022
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50. Structural disconnectome mapping of cognitive function in poststroke patients

Author

Kolskår, Knut K., primary, Ulrichsen, Kristine M., additional, Richard, Genevieve, additional, Dørum, Erlend S., additional, de Schotten, Michel Thiebaut, additional, Rokicki, Jaroslav, additional, Monereo‐Sánchez, Jennifer, additional, Engvig, Andreas, additional, Hansen, Hege Ihle, additional, Nordvik, Jan Egil, additional, Westlye, Lars T., additional, and Alnæs, Dag, additional

Published
2022
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