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1. Transplantation of hematopoietic progenitors in myelofibrosis.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, Luis López-Arroyo J, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

The objective of this work is to generate recommendations on the management of allogeneic stem cell transplantation (allo-SCT) in primary myelofibrosis (PMF). A comprehensive systematic review of articles published between 1999 and 2015 (January) was used as a source of scientific evidence. The recommendations were produced through a Delphi process involving a panel of 23 experts appointed by the European LeukemiaNet and the European Blood and Marrow Transplantation Group. Key questions included patient selection, donor selection, pre-transplant management, conditioning regimen, post-transplant management, prevention, and management of post-transplant relapse. Patients with intermediate-2 or high-risk disease and age < 70 years should be considered candidates for allo-SCT. Patients with intermediate-risk 1 disease and age < 65 years should be considered candidates if they have refractory transfusion-dependent anemia, or a peripheral blood (PB) blast percentage > 2%, or adverse cytogenetics. Splenectomy before transplantation must be decided on a case-by-case basis. Patients with intermediate-2 or high-risk disease who lack a human leukocyte antigen (HLA)-matched sibling or unrelated donor should be enrolled in a protocol that uses HLA non-identical donors. PB was considered the most appropriate source of hematopoietic stem cells for transplants from HLA-matched unrelated donors and siblings. The optimal intensity of the conditioning regimen has yet to be defined. Strategies such as discontinuation of immunosuppressive drugs, infusion of donor lymphocytes, or both were considered adequate to prevent clinical relapse. In conclusion, we provide consensus-based recommendations aimed at optimizing allo-SCT in PMF. Unmet clinical needs were highlighted., (Copyright: © 2022 Permanyer.)

Published
2022
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2. Consensus in acute myeloid leukemia in Mexico.

Author

Arana-Luna LL, Alvarado-Ibarra M, Silva-Michel LG, Morales-Maravilla A, González-Rubio MDC, Chávez-Aguilar LA, Tena-Iturralde MF, Mojica-Balceras L, Zapata-Canto N, Galindo-Delgado P, Miranda-Madrazo MR, Morales-Hernández AE, Silva-Vera K, Grimaldo-Gómez FA, Hernández-Caballero Á, Bates-Martin RA, Álvarez-Vera JL, Tepepa-Flores F, Teomitzi-Sánchez Ó, Fermín-Caminero DJ, Peña-Celaya JA, Salazar-Ramírez Ó, Flores-Villegas LV, Guerra-Alarcón LV, Leyto-Cruz F, Inclán-Alarcón SI, Milán-Salvatierra AI, Ventura-Enríquez Y, Pérez-Lozano U, Báez-Islas PE, Tapia-Enríquez AL, Palma-Moreno OG, Aguilar-Luévano J, Espinosa-Partida A, Pérez-Jacobo LF, Rojas-Castillejos F, Ruiz-Contreras JI, Loera-Fragoso SJ, Medina-Coral JE, Acosta-Maldonado BL, Soriano-Mercedes EJ, Saucedo-Montes EE, Valero-Saldana LM, González-Prieto SG, Nava-Villegas L, Hernández-Colin AK, Hernández-Alcántara AE, Zárate-Rodríguez PA, Ignacio-Ibarra G, Meillón-García LA, Espinosa-Bautista KA, Cruz CL, Barbosa-Loría DM, García-Castillo C, Balderas-Delgado C, Cabrera-García Á, Pérez-Zúñiga JM, Hernández-Ruiz E, Villela-Peña A, Cortés SCG, Romero-Rodelo H, Garzón-Velásquez KB, Serrano-Hernández C, Martínez-Ríos A, Pedraza-Solís ML, Martínez-Coronel JA, Narváez-Davalos IM, García-Camacho AS, Merino-Pasaye LE, Aguilar-Andrade C, Aguirre-Domínguez JA, Guzmán-Mera PG, Rosa ED, López PEF, González-Aguirre LL, Ramírez-Alfaro EM, Vera-Calderón H, Meza-Dávalos ML, Murillo-Cruz J, Pichardo-Cepín YM, and Ramírez-Romero EF

Subjects
Cell Differentiation, Consensus, Humans, Mexico, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute therapy
Abstract

Acute myeloid leukemia (AML) comprises a heterogeneous group of hematopoietic cell neoplasms of myeloid lineage that arise from the clonal expansion of their precursors in the bone marrow, interfering with cell differentiation, leading to a syndrome of bone marrow failure. AML is a consequence of genetic and epigenetic changes (point mutations, gene rearrangements, deletions, amplifications, and arrangements in epigenetic changes that influence gene expression) in hematopoietic precursor cells, which create a clone of abnormal cells that are capable of proliferating but cannot differentiate into mature hematopoietic cells or undergo programmed cell death. The diagnosis requires more than 20% myeloid blasts in the bone marrow and certain cytogenic abnormalities. Treatment will depend on age, comorbidities, and cytogenetic risk among the most frequent., (Copyright: © 2022 Permanyer.)

Published
2022
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3. Pregnancy in myeloproliferative neoplasms.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Myeloproliferative neoplasms (MPN) are associated with a significant risk of thrombosis and the hypercoagulable environment of pregnancy increases this risk. The most frequent gestational complications consist of spontaneous abortion, thrombosis, bleeding, and hypertensive disease of pregnancy. Treatment depends on thrombotic risk, gestational trimester, and myeloproliferative neoplasm., (Copyright: © 2022 Permanyer.)

Published
2022
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4. Polycythemia vera.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Gissell Aguirre-Reyes O, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Alberto Bates-Martín R, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Ángeles Rosales-López ML, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Polycythemia vera (PV) is mainly characterized by erythrocytosis, thrombotic and hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic progression and/or leukemic evolution over time. The diagnosis is made based on the 2016 WHO criteria. The treatment of PV focuses on rapidly reducing the erythrocyte mass, either by means of phlebotomies or with cytoreductive treatment, and the reduction of thrombotic risk by correcting cardiovascular risk factors and the use of platelet antiaggregants., (Copyright: © 2022 Permanyer.)

Published
2022
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5. Abo Blood Group, Atherothrombotic Comorbidities, and COVID-19: A Case-Control Study of their Association in the Mexican Population.

Author

Gamboa-Aguilar J, Zamorano-Montaño ÁC, Enríquez-Osorio A, Torres-Cubillas W, López-Arroyo JL, Chapol JAM, Zurita-Martínez H, Pascual JR, Saldaña-Campos E, Rojas-Castillejos F, Madera-Maldonado CE, Peñafiel COR, Maldonado EB, Rascón RG, Hernández-Juárez J, Silos-Briones G, Domínguez SM, Pérez-Ramírez ÓJ, Sosa-Camas RE, Romero-López C, Guzmán-Chores L, Amador-Sánchez R, Ledesma-de la Cruz C, Campos-Cabrera G, Ramírez-Chávez LL, Esparza-García JC, Vela-Ojeda J, García-Chávez J, González-Trejo JJ, Rodríguez-Mejorada SM, Rosado-Castro RA, de Arredondo RAS, Pérez-Hernández VH, Majluf-Cruz K, Domínguez-Reyes V, Arreola-Diaz R, Alvarado-Moreno JA, and Majluf-Cruz A

Subjects
Adult, Case-Control Studies, Female, Humans, Male, Prospective Studies, Retrospective Studies, SARS-CoV-2, ABO Blood-Group System, COVID-19
Abstract

Background: COVID-19 has been associated with negative results in patients with A blood group and with a better evolution in O blood group individuals., Aim: Because the evidence regarding ABO blood groups and COVID was empirically not that clear in our country, we tested the association regarding COVID-19 and blood groups., Material and Methods: Adult patients were enrolled in this prospective, case-control, observational multicenter study. Patients with a confirmed diagnosis of COVID-19 were assigned to one of three groups based on the clinical presentation of the infection. Age, gender, ABO and Rh blood groups, body mass index, history of diabetes mellitus or high blood pressure, and smoking were recorded directly or from their clinical charts. ABO blood group was obtained from 5,000 blood donors (50% each gender). Atherothrombotic variables were compared with a nation-wide data collection., Results: A total of 2,416 patients with COVID-19 were included (women:39.6%; men:60.4%). There were no significant differences between cases and controls in terms of age. O blood group was the most frequently found in healthy donors and COVID-19 patients, but this blood group was significantly higher in COVID-19 patients vs. healthy donors. ABO blood group was not associated with the final health status in COVID-19 patients. Obesity, diabetes mellitus, hypertension and smoking were significantly more frequent among COVID-19 patients., Conclusion: The proposed protective effect of the O blood group in COVID-19 patients could not be reproduced in the Mexican population while some atherothrombotic risk factors had a significant effect on the clinical evolution., Competing Interests: Conflict of Interests None declared., (Copyright © 2021. Published by Elsevier Inc.)

Published
2022
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6. Risks in invasive procedures.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Luis Álvarez-Vera J, Rojas-Castillejos F, Peñaloza-Ramírez R, Alejandro Carballo-Zarate A, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Patients with myeloproliferative neoplasms have an increased risk of thrombosis and bleeding. This risk must be identified, as well as individualizing the therapeutic strategy before invasive procedures; adequate cytoreduction reduces the risk of complications., (Copyright: © 2022 Permanyer.)

Published
2022
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7. Thrombotic events.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Major thrombotic complications in myeloproliferative neoplasms (MPNs) represent an important clinical problem due to their high morbidity, the complexity of their management, and their associated mortality. The appearance of a thrombosis implies a high thrombotic risk stratification of the MPN and determines the initiation or optimization of cytoreductive treatment and the use of antiplatelet or anticoagulant therapy as secondary prophylaxis. The incidence of thrombosis at the time of diagnosis is higher than during the course of the disease, being located in the arterial territory in 60-70% of cases. Once thrombosis has occurred, up to 20-33% of patients experience thrombotic recurrence in the same initial vascular territory., (Copyright: © 2022 Permanyer.)

Published
2022
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8. Symptom control.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

In addition to symptoms secondary to splenomegaly, microvascular abnormalities, and thrombohemorrhagic complications, patients with MPN may experience a significant symptom burden attributed to an increase in circulating inflammatory cytokines. These symptoms can be severe and limit quality of life. Therefore, in addition to the prevention of complications, one of the objectives of the treatment of MPN is the control of symptoms., (Copyright: © 2022 Permanyer.)

Published
2022
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9. Essential thrombocythaemia.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Ángeles Rosales-López ML, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Essential thrombocythemia (ET) is a chronic Philadelphia-negative myeloproliferative neoplasm that has its main involvement in the megakaryopoietic lineage, generating sustained thrombocytosis in peripheral blood and an increase in the number of mature megakaryocytes in the bone marrow. In addition to marked thrombocytosis, it is characterized by increased thrombotic or hemorrhagic risk and the presence of constitutional symptoms. Patients with ET have a low but known risk of disease progression to myelofibrosis and/or acute leukemia. The diagnosis is made based on the 2016 WHO criteria. At present, available treatments for patients with ET are mainly aimed at minimizing the risk of thrombosis and/or bleeding., (Copyright: © 2022 Permanyer.)

Published
2022
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10. First inter-institutional consensus on Chronic Myeloproliferative Neoplasms.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Luis Álvarez-Vera J, Rojas-Castillejos F, Peñaloza-Ramírez R, Alejandro Carballo-Zarate A, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Edna Moralws-Hernández A, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Alejandro Jiménez-Ochoa M, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

The objective of the consensus is to make available to the professionals of the different public health institutions in our country, who are in charge of these diseases, the most relevant and up-to-date information about their diagnosis and treatment in clinical practice. With this inter-institutional consensus we hope to contribute to improving the quality of care for patients with chronic myeloproliferative neoplasms throughout the Mexican Republic, to unify criteria in both diagnosis and treatment of the different myeloproliferative diseases., (Copyright: © 2022 Permanyer.)

Published
2022
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11. Myelofibrosis: diagnosis and treatment.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Conventional treatment has limited impact on the patients' survival; it includes a wait-and-see approach for asymptomatic patients, erythropoiesis-stimulating agents, androgens, or immunomodulatory agents for anemia, cytoreductive drugs such as hydroxyurea for the splenomegaly and constitutional symptoms, and splenectomy or radiotherapy in selected patients. The discovery of the Janus kinase (JAK) 2 mutation triggered the development of molecular targeted therapy of MF. The JAK inhibitors are effective in both JAK2-positive and JAK2-negative MF; one of them, ruxolitinib, is the current best available therapy for MF splenomegaly and constitutional symptoms. Although ruxolitinib has changed the therapeutic scenario of MF, there is no clear indication of a disease-modifying effect. Allogeneic stem cell transplantation remains the only curative therapy of MF, but due to its associated morbidity and mortality, it is usually restricted to eligible high- and intermediate-2-risk MF patients. To improve current therapeutic results, the combination of JAK inhibitors with other agents is currently being tested, and newer drugs are being investigated., (Copyright: © 2022 Permanyer.)

Published
2022
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12. Consensus on hemophilia in Mexico

Author

López-Arroyo JL, Pérez-Zúñiga JM, Merino-Pasaye LE, Saavedra-González A, Alcivar-Cedeño LM, Álvarez-Vera JL, Anaya-Cuellar I, Arana-Luna LL, Ávila-Castro D, Bates-Martín RA, Cesarman-Maus G, Chávez-Aguilar LA, de la Peña-Celaya JA, Espitia-Ríos ME, Estrada-Domínguez P, Fermín-Caminero D, Flores-Patricio W, Chávez JG, García-Lee MT, González-Pérez MDC, González-Rubio MDC, González-Villareal MG, Ramírez-Moreno F, Hernández-Colin AK, Hernández-Ruiz E, Herrera-Olivares W, Leyto-Cruz F, Loera-Fragoso S, Martínez-Ríos A, Miranda-Madrazo MR, Morales-Hernández A, Nava-Villegas L, Orellana-Garibay JJ, Palma-Moreno OG, Paredes-Lozano EP, Peña-Alcántara P, Pérez-Lozano U, Pichardo-Cepín YM, Reynoso-Pérez AC, Rodríguez-Serna M, Rojas-Castillejos F, Romero-Rodelo H, Ruíz-Contreras JI, Segura-García A, Silva-Vera K, Soto-Cisneros PM, Tapia-Enríquez AL, Tavera-Rodríguez MG, Teomitzi-Sánchez Ó, Tepepa-Flores F, Valencia-Rivas MD, Valle-Cárdenas T, Varela-Constantino A, Javier-Morales A, Martínez-Ramírez MA, Tena-Cano S, Terrazas-Marín R, Vilchis-González SP, Villela-Peña A, Mena-Zepeda V, and Ibarra MA

Subjects
Blood Coagulation Factors adverse effects, Blood Coagulation Factors therapeutic use, Diagnosis, Differential, Factor IX analysis, Factor IX immunology, Factor VIII analysis, Factor VIII immunology, Female, Genetic Testing, Hemarthrosis diagnosis, Hemarthrosis etiology, Hemarthrosis therapy, Hemostasis genetics, Humans, Isoantibodies analysis, Life Style, Male, Mexico, Preoperative Care methods, Consensus, Hemophilia A complications, Hemophilia A diagnosis, Hemophilia A genetics, Hemophilia A therapy, Hemophilia B complications, Hemophilia B diagnosis, Hemophilia B genetics, Hemophilia B therapy
Published
2021
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13. Mexican consensus on Hodgkin's lymphoma.

Author

Álvarez-Vera JL, Aguilar-Luevano J, Alcívar-Cedeño LM, Arana-Luna LL, Arteaga-Ortiz L, Báez-Islas PE, Carolina-Reynoso A, Cesarman-Maus G, Peña-Celaya JA, Espitia-Ríos ME, Fermín-Caminero DJ, Flores-Patricio W, García-Camacho AS, Guzmán-Mora PG, Hernández-Colín AK, Hernández-Ruiz E, Herrera-Olivares W, Jacobo-Medrano E, Loera-Fragoso SJ, Macías-Flores JP, Martínez-Ramírez MA, Medina-Guzmán L, Milán-Salvatierra AI, Montoya-Jiménez L, Morales-Adrián JJ, Mujica-Martínez A, Nava-Villegas L, Orellana-Garibay JJ, Palma-Moreno OG, Pérez-Zúñiga JM, Pérez-Gómez KD, Pichardo-Cepín YM, Rojas-Castillejos F, Romero-Martínez E, Romero-Rodelo H, Segura-García A, Silva-Vera K, Tapía-Enríquez AL, Teomitzi-Sánchez Ó, Tepepa-Flores F, Vilchis-González SP, Villela-Peña A, Guerra-Alarcón LV, Reséndiz-Olea R, Banda-García L, Paredes-Lozano EP, and Alvarado-Ibarra M

Subjects
Age Factors, Algorithms, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cell Transformation, Neoplastic pathology, Humans, Immunotherapy methods, Lymphoma, AIDS-Related etiology, Mexico, Neoplasm Staging, Positron Emission Tomography Computed Tomography, Prognosis, Reed-Sternberg Cells pathology, Consensus, Hodgkin Disease genetics, Hodgkin Disease pathology, Hodgkin Disease therapy
Abstract

El linfoma de Hodgkin (LH) se debe a la transformación clonal de células originadas en los linfocitos B, lo que genera las células binucleadas patognomónicas de Reed-Sternberg. El LH es una enfermedad de células B con una distribución bimodal, con mayor incidencia en la adolescencia y la tercera década de la vida y un segundo pico en personas mayores de 55 años. Las células del LH clásico habitualmente sufren una reprogramación de la expresión génica, ya que pierden la expresión de la mayoría de los genes típicos de las células B y han adquirido la expresión de múltiples genes que son típicos de otros tipos de células del sistema inmunitario. El algoritmo de tratamiento dependerá si se trata de LH clásico o de predominio linfocítico, si es un estadio temprano con marcadores de pronóstico desfavorables o no, el esquema inicial de manejo y si existe enfermedad voluminosa, entre las variables más relevantes., Hodgkin’s lymphoma (HL) is due to the clonal transformation of cells originating from B lymphocytes, generating the pathognomonic binucleate Reed-Sternberg cells. HL is a B cell disease with a bimodal distribution, with higher incidence in adolescence and the third decade of life, showing a second peak in people over 55 years of age. Classic Hodgkin lymphoma cells routinely undergo gene expression reprogramming, as they lose the expression of most of the typical B-cell genes and acquire the expression of multiple genes that are typical of other types of cells in the immune system. The treatment algorithm will depend on whether it is classic or predominantly lymphocytic HL, if it is early stage with unfavorable prognostic markers or not, the initial management regimen, and whether there is bulky disease, among the most relevant variables., (Copyright: © 2021 Permanyer.)

Published
2021
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14. Consensus on hemophilia in Mexico.

Author

López-Arroyo JL, Pérez-Zúñiga JM, Merino-Pasaye LE, Saavedra-González A, Alcivar-Cedeño LM, Álvarez-Vera JL, Anaya-Cuellar I, Arana-Luna LL, Ávila-Castro D, Bates-Martín RA, Cesarman-Maus G, Chávez-Aguilar LA, Peña-Celaya JA, Espitia-Ríos ME, Estrada-Domínguez P, Fermín-Caminero D, Flores-Patricio W, Chávez JG, García-Lee MT, González-Pérez MDC, González-Rubio MDC, González-Villareal MG, Ramírez-Moreno F, Hernández-Colin AK, Hernández-Ruiz E, Herrera-Olivares W, Leyto-Cruz F, Loera-Fragoso S, Martínez-Ríos A, Miranda-Madrazo MR, Morales-Hernández A, Nava-Villegas L, Orellana-Garibay JJ, Palma-Moreno OG, Paredes-Lozano EP, Peña-Alcántara P, Pérez-Lozano U, Pichardo-Cepín YM, Reynoso-Pérez AC, Rodríguez-Serna M, Rojas-Castillejos F, Romero-Rodelo H, Ruíz-Contreras JI, Segura-García A, Silva-Vera K, Soto-Cisneros PM, Tapia-Enríquez AL, Tavera-Rodríguez MG, Teomitzi-Sánchez Ó, Tepepa-Flores F, Valencia-Rivas MD, Valle-Cárdenas T, Varela-Constantino A, Javier-Morales A, Martínez-Ramírez MA, Tena-Cano S, Terrazas-Marín R, Vilchis-González SP, Villela-Peña A, Mena-Zepeda V, and Ibarra MA

Subjects
Algorithms, Mexico, Hemophilia A diagnosis, Hemophilia A etiology, Hemophilia A therapy
Abstract

Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles, and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion-transmitted infections), or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology characterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia., (Copyright: © 2020 Permanyer.)

Published
2021
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15. Mexican Consensus on Hodgkin's Lymphoma.

Author

Álvarez-Vera JL, Aguilar-Luevano J, Alcívar-Cedeño LM, Arana-Luna LL, Arteaga-Ortiz L, Báez-Islas PE, Carolina-Reynoso A, Cesarman-Maus G, Peña-Celaya JA, Espitia-Ríos ME, Fermín-Caminero DJ, Flores-Patricio W, García-Camacho AS, Guzmán-Mora PG, Hernández-Colín AK, Hernández-Ruiz E, Herrera-Olivares W, Jacobo-Medrano E, Loera-Fragoso SJ, Macías-Flores JP, Martínez-Ramírez MA, Medina-Guzmán L, Milán-Salvatierra AI, Montoya-Jiménez L, Morales-Adrián JJ, Mujica-Martínez A, Nava-Villegas L, Orellana-Garibay JJ, Palma-Moreno OG, Pérez-Zúñiga JM, Pérez-Gómez KD, Pichardo-Cepín YM, Rojas-Castillejos F, Romero-Martínez E, Romero-Rodelo H, Segura-García A, Silva-Vera K, Tapía-Enríquez AL, Teomitzi-Sánchez Ó, Tepepa-Flores F, Vilchis-González SP, Villela-Peña A, Guerra-Alarcón LV, Reséndiz-Olea R, Banda-García L, Paredes-Lozano EP, and Alvarado-Ibarra M

Subjects
Age Distribution, Algorithms, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Gene Expression, Humans, Mexico, Neoplasm Staging, Positron Emission Tomography Computed Tomography, Consensus, Hodgkin Disease drug therapy, Hodgkin Disease epidemiology, Hodgkin Disease genetics, Hodgkin Disease pathology, Reed-Sternberg Cells pathology
Abstract

Hodgkin's lymphoma is due to the clonal transformation of cells originating from B lymphocytes, generating the pathognomonic binucleate Reed-Sternberg cells. Hodgkin's lymphoma is a B cell disease with a bimodal distribution, with higher incidence in adolescence and the third decade of life, showing a second peak in people over 55 years of age. Classic Hodgkin lymphoma cells routinely undergo gene expression reprogramming, as they lose the expression of most of the typical B-cell genes and acquire the expression of multiple genes that are typical of other types of cells in the immune system. The treatment algorithm will depend on whether it is classic or predominantly lymphocytic HL, if it is early stage with unfavorable prognostic markers or not, the initial management regimen, and whether there is bulky disease, among the most relevant variables., (Copyright: © 2021 Permanyer.)

Published
2021
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16. Mexican Concensus of Multiple Myeloma.

Author

de la Peña-Celaya JA, Aguilar-Luevano J, Alcivar-Cedeño LM, Álvarez-Vera JL, Anaya-Cuellar I, Añorve-Hernández E, Arana-Luna LL, Arteaga-Ortíz L, Báez-Islas PE, Banda-García LI, Bates-Martín RA, Campa-Monroy DI, Cardiel-Silva M, Castillo-Salas ÁJ, Cota-Rangel X, Díaz-Vargas G, Espitia-Ríos ME, Estrada-Domínguez P, Fermín-Caminero D, García-Camacho A, García-Castillo C, Garzón-Velásquez KB, Gil-Rondero C, Guerra-Alarcón LV, Hernández-Colín AK, Hernández-Ruiz E, Hernández-Alcántara AE, Hernández-Cervantes SA, Herrera-Olivares W, Ignacio-Ibarra G, Inclán-Alarcón SI, Leyto-Cruz F, Macías-Flores JP, Vega AM, Martínez-Ramírez MA, Martínez-Coronel J, Medina-Coral JE, Meza-Dávalos L, Montoya-Jiménez L, Morales-Hernández A, Morales-López E, Morales-Adrián JJ, Azcué MM, Mújica-Martínez A, Murillo-Cruz JL, Nájera-Martínez J, Narváez-Sarmiento IM, Nava-Villegas L, Nava-Alpide MA, Orellana Garibay JJ, Palafox-Zaldívar MT, Palma-Moreno OG, Paredes-Lozano EP, Pedraza-Colín ML, Pérez-Zúñiga JM, Pérez-Lizardi AB, Rojas-Castillejos F, Romero-Martínez E, Romero-Rodelo H, Ruiz-Contreras J, Saavedra-González A, Saucedo-Montes E, Silva-Michel LG, Silva-Vera K, Teomitzi-Sánchez Ó, Tepepa-Flores F, Ventura-Enríquez Y, Villela-Peña A, Vilchis-González SP, Zapata-Canto N, Zárate-Rodríguez PA, and Alvarado-Ibarra M

Subjects
Algorithms, Humans, Mexico, Multiple Myeloma complications, Multiple Myeloma diagnosis, Multiple Myeloma therapy
Abstract

To identify this increasingly common pathology, known as multiple myeloma (MM), it is necessary to refer to the specific factors that characterize it; to this end, the classic criteria known as CRAB (hyperkalemia, renal failure, anemia, and lytic lesions) are available, in which renal failure is one of the most frequent complications. Recently, three indisputable biomarkers have been described for the diagnostic support for MM, which are: more than 10% of clonal plasma cells in bone marrow or, a biopsy that corroborates the presence of a plasmacytoma, light chain ratio ≥ 100 mg/dL and more than one focal lesion on magnetic resonance imaging. A differential diagnosis for plasma cell leukemia, solitary bone plasmacytoma, and extramedullary plasmacytoma should always be considered. Being this an incurable disease, a lot of research has been done regarding its therapeutic management, whose main objective is the disappearance of plasma cells and the patient clinical improvement. Melphalan was the first drug that showed a benefit in 1958 and afterward, with the addition of a steroid as a second drug, it was possible to improve response rates. Subsequently, different molecules were studied, forming multiple combinations, and achieving better rates of overall survival and progression-free survival. Years later, with the arrival of proteasome inhibitors such as bortezomib, and immunomodulators such as thalidomide and lenalidomide, an important turnaround in the disease has been seen, as deeper responses, more prolonged remissions, and improvement in the quality of life of patients have been achieved. This consensus has the purpose of integrating a group of Mexican specialists and promoting the updating of this pathology., (Copyright: © 2020 Permanyer.)

Published
2020
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