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Objective: In Peru, there have been more than 2 million international migrants from 1990 to 2021, including 12.6 % of healthcare professionals. This migration has resulted in a lack of human resources and work overload. Consequently, at the national level, there is a need to identify the factors associated with the intention to migrate among professionals in healthcare facilities. At the international level, it has been found that one of the main motivations is job dissatisfaction. Therefore, the main objective of this study is to estimate the association between job satisfaction and the intention to migrate among Peruvian physicians and nurses. Materials and methods: An observational analytical study of secondary databases using responses from physicians and nurses from the 2016 Encuesta Nacional de Satisfacción de Usuarios en Salud (Ensusalud - National Survey of User Satisfaction in Health). The independent variable was job satisfaction among healthcare personnel, while the dependent variable was their intention to migrate. A comparison of weighted rates of the intention to migrate between job satisfaction categories and other covariates was performed using the chi-square test with second-order Rao-Scott correction. Subsequently, log-binomial models were used to estimate adjusted prevalence ratios (aPR). Results: The sample included 5,098 professionals. Among them, 25 % had the intention to migrate. However, such intention was not associated with job satisfaction (aPR: 1.10; 95 % CI: 0.72-1.68). Furthermore, we found that participants aged between 20 and 40 years, those who did not have a professional specialty, had an intermediate command of other languages and perceived a decline in their health due to work had an increase in the intention to migrate of 250 %, 27 %, 34 % and 61 %, respectively. Conclusion: We did not find an association between job satisfaction and the intention to migrate among Peruvian physicians and nurses. [ABSTRACT FROM AUTHOR]