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2. Deep Deltoid Ligament Reconstruction Utilizing Suture Augmentation via an Arthroscopically- Assisted Approach: A Novel Technique and Case Series

Author

Frederic J. Washburn DO, Conner S. Roggy DO, Britni Tran BS, Casey W. Pyle DO, and Thomas G. Harris MD

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Trauma; Arthroscopy Introduction/Purpose: Deltoid ligament rupture is a common occurrence in the setting of acute ankle fractures. The indications for surgical restoration of the deltoid ligament complex vary considerably throughout the literature. If medial ankle instability exists after ankle fracture fixation, repair or reconstruction of the deltoid ligament complex may be performed, which is traditionally done via an open approach. While the superficial deltoid is easily accessed with an open approach, the deep deltoid ligament is extremely difficult to visualize. We present a novel technique for reconstruction of the deep deltoid ligament complex utilizing suture augmentation via an arthroscopically-assisted approach and present our outcomes. With this method, the deep deltoid ligament disruption is easily visualized and reconstructed in a minimally invasive manner through an accessory anteromedial arthroscopy portal. Methods: This is a technique guide and retrospective case series. Data was obtained via chart review including pre-operative, intraoperative, and post-operative follow ups. Variables such as age, weight, body mass index (BMI), sex, side, history of previous ankle surgery, preoperative ambulatory status, length of hospital stay, as well as disposition were documented. Radiographs were reviewed for evidence of restoration of the medial clear space as well as hardware position and bony union. In addition, a technique guide was developed using expert surgeon experience and opinion while using this novel technique. Results: 7 patients who underwent this novel technique were reviewed with an average follow up time of six months (3-8 months). All patients suffered bimalleolar or trimalleolar equivalent fractures. Patients were indicated for deep deltoid ligament reconstruction if medial ankle instability existed intraoperatively with valgus stress testing under fluoroscopy. Medial clear space decreased from a mean 11mm preoperatively to 3.3mm postoperatively. 6 patients returned to ambulation without brace by three months postoperatively. One patient demonstrated increased medial clear space measured at 6.6mm postoperatively and residual pain on follow up, but was treated conservatively and able to progress to weight bearing as tolerated by 6 months. One patient developed a keloid scar that required a steroid injection. No postoperative infections occurred. Conclusion: Deep deltoid ligament reconstruction utilizing suture augmentation via an arthroscopically-assisted approach should be considered in patients who have residual medial ankle instability after ankle fracture fixation. This novel technique allows visualization of the deep deltoid ligament complex and reconstruction in a minimally invasive manner via an accessory anteromedial arthroscopy portal. Our short term outcomes demonstrate success in restoring ankle function and radiographic parameters of the medial clear space. Further studies are needed to evaluate long term postoperative functional outcomes, stability, and development of post-traumatic arthritis.

Published
2023
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4. Mobilization With Femoral Catheters in the Burn ICU: A Retrospective Review Following Change in Practice Guidelines.

Author

O'Neil, Audrey M, Boyd, Allison, Rush, Cassandra, Roggy, David, Walroth, Todd, and Hartman, Brett

Subjects
DIALYSIS catheters, JUDGMENT (Psychology), CATHETERS, ERGOMETRY, RETROSPECTIVE studies, EARLY ambulation (Rehabilitation)
Abstract

Femoral catheters are commonly viewed as a barrier to Burn ICU mobility progression due to anatomical location and potential risk of complications. The purpose of this review was to examine outcomes and complication rates following implementation of femoral catheter mobilization guidelines, as well as determine safety and feasibility of mobilization with femoral catheters in place within the burn population. A retrospective review was completed on 17 patients prior to and following the implementation of new femoral catheter mobility guidelines, 34 patients total. Burn therapy notes were reviewed for burn admissions with at least 1 femoral catheter in place, including arterial, central, and dialysis catheters. Demographic data, admission statistics, line placement timelines, and active mobility achieved during therapy sessions were recorded for both the nonmobilization group (NMG) and mobilization group (MG). The 34 patients reviewed had 99 total lines placed (30 NMG, 69 MG). Change in mobility protocols for the MG resulted in more therapy sessions (n = 516 vs 281) and a significant increase in active mobility sessions (n = 83 vs 5, P <.001), including 146 total mobility activities such as transitions to chairs, tilt table, sitting edge of bed, standing, active chair transfers, ambulation, and cycle ergometry. No catheter-associated adverse events occurred during active mobility sessions and no complications were associated with participation in mobility. This review supports that the presence of femoral catheters alone should not limit the progression of mobility interventions with the use of clinical judgment in specialty-trained burn therapists. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis

Author

Renosi, Florian, Roggy, Anne, Giguelay, Ambre, Soret, Lou, Viailly, Pierre-Julien, Cheok, Meyling, Biichle, Sabeha, Angelot-Delettre, Fanny, Asnafi, Vahid, Macintyre, Elizabeth, Geffroy, Sandrine, Callanan, Mary, Petrella, Tony, Deconinck, Eric, Daguindau, Etienne, Harrivel, Véronique, Bouyer, Sabrina, Salaun, Véronique, Saussoy, Pascale, Feuillard, Jean, Fuseau, Pascal, Saas, Philippe, Adotévi, Olivier, Jardin, Fabrice, Ferrand, Christophe, Preudhomme, Claude, Colinge, Jacques, Roumier, Christophe, and Garnache-Ottou, Francine

Published
2021
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8. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Author

Bond, Jonathan, Krzywon, Aleksandra, Lhermitte, Ludovic, Roumier, Christophe, Roggy, Anne, Belhocine, Mohamed, Kheirallah, Alexander Abdulkader, Villarese, Patrick, Hypolite, Guillaume, Garnache-Ottou, Francine, Castaigne, Sylvie, Boissel, Nicolas, Asnafi, Vahid, Preudhomme, Claude, Dombret, Hervé, Laurenti, Elisa, and Macintyre, Elizabeth

Published
2021
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10. How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Author

Garnache-Ottou, Francine, Vidal, Chrystelle, Biichlé, Sabeha, Renosi, Florian, Poret, Eve, Pagadoy, Maïder, Desmarets, Maxime, Roggy, Anne, Seilles, Estelle, Soret, Lou, Schillinger, Françoise, Puyraimond, Sandrine, Petrella, Tony, Preudhomme, Claude, Roumier, Christophe, MacIntyre, Elisabeth A., Harrivel, Véronique, Desbrosses, Yohan, Gruson, Bérengère, Geneviève, Franck, Thepot, Sylvain, Drebit, Yuriy, Leguay, Thibaut, Gros, François-Xavier, Lechevalier, Nicolas, Saussoy, Pascale, Salaun, Véronique, Cornet, Edouard, Benseddik, Zehaira, Veyrat-Masson, Richard, Wagner-Ballon, Orianne, Salanoubat, Célia, Maynadié, Marc, Guy, Julien, Caillot, Denis, Jacob, Marie-Christine, Cahn, Jean-Yves, Gressin, Rémy, Rose, Johann, Quesnel, Bruno, Guerin, Estelle, Trimoreau, Franck, Feuillard, Jean, Gourin, Marie-Pierre, Plesa, Adriana, Baseggio, Lucile, Arnoux, Isabelle, Vey, Norbert, Blaise, Didier, Lacroix, Romaric, Arnoulet, Christine, Benet, Blandine, Dorvaux, Véronique, Bret, Caroline, Drenou, Bernard, Debliquis, Agathe, Latger-Cannard, Véronique, Bonmati, Caroline, Bene, Marie-Christine, Peterlin, Pierre, Ticchioni, Michel, Rohrlich, Pierre-Simon, Arnaud, Anne, Wickenhauser, Stefan, Bardet, Valérie, Brechignac, Sabine, Papoular, Benjamin, Raggueneau, Victoria, Vargaftig, Jacques, Letestu, Rémi, Lusina, Daniel, Braun, Thorsten, Foissaud, Vincent, Tamburini, Jérôme, Bennani, Hind, Freynet, Nicolas, Cordonnier, Catherine, Le Garff-Tavernier, Magali, Jacques, Nathalie, Maloum, Karim, Roos-Weil, Damien, Bouscary, Didier, Asnafi, Vahid, Lhermitte, Ludovic, Suarez, Felipe, Lengline, Etienne, Féger, Frédéric, Battipaglia, Giorgia, Mohty, Mohamad, Bouyer, Sabrina, Ghoual, Ouda, Dindinaud, Elodie, Basle, Caroline, Puyade, Mathieu, Lafon, Carinne, Fest, Thierry, Roussel, Mikael, Cahu, Xavier, Bera, Elsa, Daliphard, Sylvie, Jardin, Fabrice, Campos, Lydia, Solly, Françoise, Guyotat, Denis, Galoisy, Anne-Cécile, Eischen, Alice, Mayeur-Rousse, Caroline, Guffroy, Blandine, Recher, Christian, Loosveld, Marie, Garnier, Alice, Barlogis, Vincent, Rosenthal, Maria Alessandra, Brun, Sophie, Contentin, Nathalie, Maury, Sébastien, Callanan, Mary, Lefebvre, Christine, Maillard, Natacha, Okamba, Patricia, Ferrand, Christophe, Adotevi, Olivier, Saas, Philippe, Angelot-Delettre, Fanny, Binda, Delphine, and Deconinck, Eric

Published
2019
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11. How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Author

Francine Garnache-Ottou, Chrystelle Vidal, Sabeha Biichlé, Florian Renosi, Eve Poret, Maïder Pagadoy, Maxime Desmarets, Anne Roggy, Estelle Seilles, Lou Soret, Françoise Schillinger, Sandrine Puyraimond, Tony Petrella, Claude Preudhomme, Christophe Roumier, Elisabeth A. MacIntyre, Véronique Harrivel, Yohan Desbrosses, Bérengère Gruson, Franck Geneviève, Sylvain Thepot, Yuriy Drebit, Thibaut Leguay, François-Xavier Gros, Nicolas Lechevalier, Pascale Saussoy, Véronique Salaun, Edouard Cornet, Zehaira Benseddik, Richard Veyrat-Masson, Orianne Wagner-Ballon, Célia Salanoubat, Marc Maynadié, Julien Guy, Denis Caillot, Marie-Christine Jacob, Jean-Yves Cahn, Rémy Gressin, Johann Rose, Bruno Quesnel, Estelle Guerin, Franck Trimoreau, Jean Feuillard, Marie-Pierre Gourin, Adriana Plesa, Lucile Baseggio, Isabelle Arnoux, Norbert Vey, Didier Blaise, Romaric Lacroix, Christine Arnoulet, Blandine Benet, Véronique Dorvaux, Caroline Bret, Bernard Drenou, Agathe Debliquis, Véronique Latger-Cannard, Caroline Bonmati, Marie-Christine Bene, Pierre Peterlin, Michel Ticchioni, Pierre-Simon Rohrlich, Anne Arnaud, Stefan Wickenhauser, Valérie Bardet, Sabine Brechignac, Benjamin Papoular, Victoria Raggueneau, Jacques Vargaftig, Rémi Letestu, Daniel Lusina, Thorsten Braun, Vincent Foissaud, Jérôme Tamburini, Hind Bennani, Nicolas Freynet, Catherine Cordonnier, Magali Le Garff-Tavernier, Nathalie Jacques, Karim Maloum, Damien Roos-Weil, Didier Bouscary, Vahid Asnafi, Ludovic Lhermitte, Felipe Suarez, Etienne Lengline, Frédéric Féger, Giorgia Battipaglia, Mohamad Mohty, Sabrina Bouyer, Ouda Ghoual, Elodie Dindinaud, Caroline Basle, Mathieu Puyade, Carinne Lafon, Thierry Fest, Mikael Roussel, Xavier Cahu, Elsa Bera, Sylvie Daliphard, Fabrice Jardin, Lydia Campos, Françoise Solly, Denis Guyotat, Anne-Cécile Galoisy, Alice Eischen, Caroline Mayeur-Rousse, Blandine Guffroy, Christian Recher, Marie Loosveld, Alice Garnier, Vincent Barlogis, Maria Alessandra Rosenthal, Sophie Brun, Nathalie Contentin, Sébastien Maury, Mary Callanan, Christine Lefebvre, Natacha Maillard, Patricia Okamba, Christophe Ferrand, Olivier Adotevi, Philippe Saas, Fanny Angelot-Delettre, Delphine Binda, and Eric Deconinck

Subjects
Specialties of internal medicine, RC581-951
Abstract

Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed a nationwide network to collect data from new cases diagnosed in France. In a retrospective, observational study of 86 patients (2000-2013), we described clinical and biological data focusing on morphologies and immunophenotype. We found expression of markers associated with plasmacytoid dendritic cell origin (HLA-DRhigh, CD303+, CD304+, and cTCL1+) plus CD4 and CD56 and frequent expression of isolated markers from the myeloid, B-, and T-lymphoid lineages, whereas specific markers (myeloperoxidase, CD14, cCD3, CD19, and cCD22) were not expressed. Fifty-one percent of cytogenetic abnormalities impact chromosomes 13, 12, 9, and 15. Myelemia was associated with an adverse prognosis. We categorized chemotherapeutic regimens into 5 groups: acute myeloid leukemia (AML)–like, acute lymphoid leukemia (ALL)–like, lymphoma (cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP])–like, high-dose methotrexate with asparaginase (Aspa-MTX) chemotherapies, and not otherwise specified (NOS) treatments. Thirty patients received allogeneic hematopoietic cell transplantation (allo-HCT), and 4 patients received autologous hematopoietic cell transplantation. There was no difference in survival between patients receiving AML-like, ALL-like, or Aspa-MTX regimens; survival was longer in patients who received AML-like, ALL-like, or Aspa-MTX regimens than in those who received CHOP-like regimens or NOS. Eleven patients are in persistent complete remission after allo-HCT with a median survival of 49 months vs 8 for other patients. Our series confirms a high response rate with a lower toxicity profile with the Aspa-MTX regimen, offering the best chance of access to hematopoietic cell transplantation and a possible cure.

Published
2019
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12. Case Report: Evolution of a Severe Vascular Refractory Form of ECD Requiring Liver Transplantation Correlated With the Change in the Monocyte Subset Analysis

Author

Jérôme Razanamahery, Anne Roggy, Jean-François Emile, Alexandre Malakhia, Zaher Lakkis, Francine Garnache-Ottou, Thibaud Soumagne, Fleur Cohen-Aubart, Julien Haroche, and Bernard Bonnotte

Subjects
monocyte, histiocytosis, Erdheim–Chester disease, transplantation, vascular diagnosis, Immunologic diseases. Allergy, RC581-607
Abstract

Erdheim–Chester disease is a rare histiocytosis characterized by iconic features associated with compatible histology. Most patients have somatic mutations in the MAP-kinase pathway gene, and the mutations occur in CD14+ monocytes. Differentiation of the myeloid lineage plays a central role in the pathogenesis of histiocytosis. Monocytes are myeloid-derived white blood cells, divided into three subsets, but only the CD14++CD16− “classical monocyte” can differentiate into dendritic cells and tissue macrophages. Since most mutations occur in CD14+ cells and since ECD patients have a particular monocytic phenotype resembling CMML, we studied the correlation between disease activity and monocytic subset distribution during the course of a severe vascular form of ECD requiring liver transplantation. During early follow-up, increased CD14++CD16− “classical monocyte” associated with decreased CD14lowCD16++ “non-classical monocyte” correlated with disease activity. Further studies are needed to confirm the use of monocyte as a marker of disease activity in patients with ECD.

Published
2021
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15. Potential Therapeutic Targets for Combination Antibody Therapy against Pseudomonas aeruginosa Infections

Author

Luke L. Proctor, Whitney L. Ward, Conner S. Roggy, Alexandra G. Koontz, Katie M. Clark, Alyssa P. Quinn, Meredith Schroeder, Amanda E. Brooks, James M. Small, Francina D. Towne, and Benjamin D. Brooks

Subjects
polyclonal antibodies, antibiotic resistance, antibiotics, combination therapies, Pseudomonas aeruginosa, immunotherapies, Therapeutics. Pharmacology, RM1-950
Abstract

Despite advances in antimicrobial therapy and even the advent of some effective vaccines, Pseudomonas aeruginosa (P. aeruginosa) remains a significant cause of infectious disease, primarily due to antibiotic resistance. Although P. aeruginosa is commonly treatable with readily available therapeutics, these therapies are not always efficacious, particularly for certain classes of patients (e.g., cystic fibrosis (CF)) and for drug-resistant strains. Multi-drug resistant P. aeruginosa infections are listed on both the CDC’s and WHO’s list of serious worldwide threats. This increasing emergence of drug resistance and prevalence of P. aeruginosa highlights the need to identify new therapeutic strategies. Combinations of monoclonal antibodies against different targets and epitopes have demonstrated synergistic efficacy with each other as well as in combination with antimicrobial agents typically used to treat these infections. Such a strategy has reduced the ability of infectious agents to develop resistance. This manuscript details the development of potential therapeutic targets for polyclonal antibody therapies to combat the emergence of multidrug-resistant P. aeruginosa infections. In particular, potential drug targets for combinational immunotherapy against P. aeruginosa are identified to combat current and future drug resistance.

Published
2021
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21. Isotopic evidence for oligotrophication of terrestrial ecosystems

Author

Craine, Joseph M., Elmore, Andrew J., Wang, Lixin, Aranibar, Julieta, Bauters, Marijn, Boeckx, Pascal, Crowley, Brooke E., Dawes, Melissa A., Delzon, Sylvain, Fajardo, Alex, Fang, Yunting, Fujiyoshi, Lei, Gray, Alan, Guerrieri, Rossella, Gundale, Michael J., Hawke, David J., Hietz, Peter, Jonard, Mathieu, Kearsley, Elizabeth, Kenzo, Tanaka, Makarov, Mikhail, Marañón-Jiménez, Sara, McGlynn, Terrence P., McNeil, Brenden E., Mosher, Stella G., Nelson, David M., Peri, Pablo L., Roggy, Jean Christophe, Sanders-DeMott, Rebecca, Song, Minghua, Szpak, Paul, Templer, Pamela H., Van der Colff, Dewidine, Werner, Christiane, Xu, Xingliang, Yang, Yang, Yu, Guirui, and Zmudczyńska-Skarbek, Katarzyna

Published
2018
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24. Soil carbon storage in croplands, grasslands, forests and wetlands of French overseas territories. State of knowledge and levers for action. Summary for Policymakers March 2023

Author

Fujisaki, Kenji, Teste, Adrien, Thongo Mbou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Richard, Antoine, Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Heurtaux, Anne, Jannoyer, Magalie, Demenois, Julien, Daguet, Ellie, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, Roggy, Jean-Christophe, Fujisaki, Kenji, Teste, Adrien, Thongo Mbou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Richard, Antoine, Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Heurtaux, Anne, Jannoyer, Magalie, Demenois, Julien, Daguet, Ellie, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, and Roggy, Jean-Christophe

Published
2023

25. Stocker du carbone dans les sols agricoles et forestiers ultramarins. Synthèse biophysique sur le stockage de carbone dans les sols à La Réunion

Author

Avadi Tapia, Angel Daniel, Teste, Adrien, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Fujisaki, Kenji, Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean Marc, Avadi Tapia, Angel Daniel, Teste, Adrien, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Fujisaki, Kenji, Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, and Blazy, Jean Marc

Published
2023

26. Synthèse biophysique sur le stockage de carbone dans les sols en Guyane - version finale - mars 2023 - dans ' 4 pour 1 000 ' Outre-mer : Stocker du carbone dans les sols agricoles et forestiers ultramarins : état des connaissances et synergies avec la Trajectoire 5.0 en Guadeloupe, en Martinique, en Guyane, à La Réunion, à Mayotte, à Saint-Martin et à Saint-Barthélemy

Author

Demenois, Julien (ed.), Albrecht, Alain (ed.), Blanfort, Vincent (ed.), Blazy, Jean Marc (ed.), Fujisaki, Kenji, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Demenois, Julien (ed.), Albrecht, Alain (ed.), Blanfort, Vincent (ed.), Blazy, Jean Marc (ed.), Fujisaki, Kenji, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, and Vigne, Mathieu

Published
2023

27. Synthèse biophysique sur le stockage de carbone dans les sols en Guadeloupe

Author

Fujisaki, Kenji, Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean Marc, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Fujisaki, Kenji, Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean Marc, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, and Vigne, Mathieu

Published
2023

28. Synthèse biophysique sur le stockage de carbone dans les sols en Martinique

Author

Fujisaki, Kenji, Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean Marc, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Fujisaki, Kenji, Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean Marc, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, and Vigne, Mathieu

Published
2023

29. Synthèse biophysique sur le stockage de carbone dans la biomasse aérienne en Guyane - version finale - mars 2023 – dans ' 4 pour 1 000 ' Outre-mer : Stocker du carbone dans les sols agricoles et forestiers ultramarins : état des connaissances et synergies avec la Trajectoire 5.0 en Guadeloupe, en Martinique, en Guyane, à La Réunion, à Mayotte, à Saint-Martin et à Saint-Barthélemy

Author

Demenois, Julien (ed.), Albrecht, Alain (ed.), Blanfort, Vincent (ed.), Blazy, Jean Marc (ed.), Fujisaki, Kenji, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Herault, Bruno, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Demenois, Julien (ed.), Albrecht, Alain (ed.), Blanfort, Vincent (ed.), Blazy, Jean Marc (ed.), Fujisaki, Kenji, Teste, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoit, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Herault, Bruno, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, and Vigne, Mathieu

Published
2023

30. Etude ' 4 pour 1 000 ' Outre-mer - Stocker du carbone dans les sols agricoles et forestiers ultramarins - Etat des connaissances et leviers d'actions dans les départements et régions d'Outre-mer - Rapport final

Author

Fujisaki, Kenji, Teste, Adrien, Thongo M'Bou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Ozier-Lafontaine, Harry, Richard, A., Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Demenois, Julien, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, Roggy, Jean-Christophe, Fujisaki, Kenji, Teste, Adrien, Thongo M'Bou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Ozier-Lafontaine, Harry, Richard, A., Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Demenois, Julien, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, and Roggy, Jean-Christophe

Abstract

Coordonnée par le Cirad en partenariat avec INRAE et l'IRD, l'étude ≪ 4 pour 1000 ≫ Outre-mer dresse un bilan inédit des stocks de carbone du sol des territoires ultramarins. Les auteurs formulent des recommandations opérationnelles et de recherche pour preserver ces stocks élevés et répondre aux grands enjeux actuels de l'agriculture face au changement climatique au niveau national et territorial. Si le potentiel des sols métropolitains a fait l'objet d'une evaluation en 2019, celui des territoires ultramarins était jusqu'ici méconnu. Dans le cadre de la présente étude, les auteurs dressent pour la premiere fois un état des lieux des connaissances pour la Guadeloupe, la Martinique, la Guyane, La Reunion, Mayotte, Saint-Martin et Saint-Barthélemy.

Published
2023

31. Stocker du carbone dans les sols agricoles et forestiers ultramarins - Résumé pour décideurs - Etat des connaissances et leviers d'actions dans les départements et régions d'Outre-mer

Author

Fujisaki, Kenji, Teste, Adrien, Thongo Mbou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Richard, Antoine, Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Heurtaux, Anne, Jannoyer, Magalie, Demenois, Julien, Daguet, Ellie, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, Roggy, Jean-Christophe, Fujisaki, Kenji, Teste, Adrien, Thongo Mbou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Richard, Antoine, Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Heurtaux, Anne, Jannoyer, Magalie, Demenois, Julien, Daguet, Ellie, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, and Roggy, Jean-Christophe

Published
2023

32. Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

Author

Emadali, Anouk, Hoghoughi, Neda, Duley, Samuel, Hajmirza, Azadeh, Verhoeyen, Els, Cosset, Francois-Loic, Bertrand, Philippe, Roumier, Christophe, Roggy, Anne, Suchaud-Martin, Céline, Chauvet, Martine, Bertrand, Sarah, Hamaidia, Sieme, Rousseaux, Sophie, Josserand, Véronique, Charles, Julie, Templier, Isabelle, Maeda, Takahiro, Bruder-Costa, Juliana, Chaperot, Laurence, Plumas, Joel, Jacob, Marie-Christine, Bonnefoix, Thierry, Park, Sophie, Gressin, Remy, Tensen, Cornelis P., Mecucci, Cristina, Macintyre, Elizabeth, Leroux, Dominique, Brambilla, Elisabeth, Nguyen-Khac, Florence, Luquet, Isabelle, Penther, Dominique, Bastard, Christian, Jardin, Fabrice, Lefebvre, Christine, Garnache, Francine, and Callanan, Mary B.

Published
2016
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33. Synthèse biophysique sur le stockage de carbone dans les sols en Guyane: 4 pour 1 000 » Outre-mer : Stocker du carbone dans les sols agricoles et forestiers ultramarins : état des connaissances et synergies avec la Trajectoire 5.0 en Guadeloupe, en Martinique, en Guyane, à La Réunion, à Mayotte, à Saint-Martin et à Saint-Barthélemy

Author

Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean- Marc, Fujisaki, Kenji, Testé, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoît, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut de Recherche pour le Développement (IRD [Réunion]), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agrosystèmes tropicaux (ASTRO), ADEME, CIRAD, INRAE, and IRD

Subjects
systèmes de culture, forêt, [SDE]Environmental Sciences, 4 p 1000, Guyane, pédoclimat
Abstract

Le présent rapport fait état des connaissances acquises à ce jour par la communauté scientifique sur les stocks de COS du territoire. Il présente ensuite les principaux déterminants à leur variabilité spatiale et temporelle. Il expose pour finir l’effet du changement d’usage des sols, des pratiques agricoles et de gestion forestière.

Published
2023

34. 4 pour 1 000 » Outre-mer : Stocker du carbone dans les sols agricoles et forestiers ultramarins : état des connaissances et synergies avec la Trajectoire 5.0 en Guadeloupe, en Martinique, en Guyane, à La Réunion, à Mayotte, à Saint-Martin et à Saint-Barthélemy

Author

Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean- Marc, Fujisaki, Kenji, Testé, Adrien, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoît, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Hérault, Bruno, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Margot, Moniot, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut de Recherche pour le Développement (IRD [Réunion]), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agrosystèmes tropicaux (ASTRO), ADEME, CIRAD, INRAE, and IRD

Subjects
changement climatique, forêt, [SDE]Environmental Sciences, texture du sol, deforestation, changement d'usage, Guyane
Abstract

Avec 95 % de sa surface recouverte de forêt et une démographie croissante entraînant uneaugmentation des besoins en surfaces exploitables, la Guyane présente également de fortsenjeux liés au carbone contenu dans la biomasse forestière. A la demande de l’Ademe, lecarbone aérien (CA) a également été étudié et est présenté dans le présent rapport.

Published
2023

35. Synthèse biophysique sur le stockage de carbone dans les sols en Martinique: 4 pour 1 000 » Outre-mer : Stocker du carbone dans les sols agricoles et forestiers ultramarins : état des connaissances et synergies avec la Trajectoire 5.0 en Guadeloupe, en Martinique, en Guyane, à La Réunion, à Mayotte, à Saint-Martin et à Saint-Barthélemy

Author

Demenois, Julien, Albrecht, Alain, Blanfort, Vincent, Blazy, Jean- Marc, Fujisaki, Kenji, Avadi, Angel, Bréchet, Laëtitia, Brossard, Michel, Burban, Benoît, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Freycon, Vincent, Richard, Antoine, Roggy, Jean-Christophe, Sierra, Jorge, Stahl, Clément, Tillard, Emmanuel, Thuriès, Laurent, Todoroff, Pierre, Vayssières, Jonathan, Versini, Antoine, Vigne, Mathieu, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut de Recherche pour le Développement (IRD [Réunion]), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agrosystèmes tropicaux (ASTRO), ADEME, and CIRAD, IRD, INRAE

Subjects
Martinique -- France, [SDE]Environmental Sciences, pratiques, 4 p 1000, système de culture, pédoclimat
Abstract

L’objectif de cette synthèse est de fournir un état des lieux des travaux réalisés sur le stockage decarbone organique des sols (COS) en Martinique. Compte tenu des données disponibles, lesthématiques suivantes sont développées dans ce document, après avoir une présentation du contextebiophysique du territoire :- Déterminants des stocks de COS et spatialisation des stocks de COS ;- Effet des changements d’usage des sols sur les stocks de COS ;- Effet des changements de pratiques de gestion des sols sur les stocks de COS.

Published
2023

36. AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network

Author

Adriana Plesa, Florent Dumezy, Stéphanie Mathis, Anne-Catherine Lhoumeau, Valerie Bardet, Véronique Saada, Isabelle Arnoux, Bouchra Badaoui, Edouard Cornet, Jennifer Osman, Estelle Guerin, Nicolas Chapuis, Franck Genevieve, Rémi Letestu, Delphine Manzoni, Anne Roggy, Mikael Roussel, Véronique Harrivel, Elsa Bera, Caroline Mayeur-Rousse, Hélène Lapillonne, Richard Veyrat-Masson, Lydia Campos, Magali Le Garff-Tavernier, Tatiana Raskovalova, Francois Vergez, Julien Guy, Agnes Charpentier, Claire Hemar, Valerie Goncalves Monteiro, Frederic Fegier, Karine Celli-Lebras, Raphael Itzykson, Herve Dombret, Claude Preudhomme, and Christophe Roumier

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

37. Five-Year Retrospective Analysis of a Vented Mobility Algorithm in the Burn ICU

Author

Audrey M, O'Neil, Cassandra, Rush, Laura, Griffard, David, Roggy, Allison, Boyd, and Brett C, Hartman

Subjects
Burn Units, Rehabilitation, Emergency Medicine, Humans, Surgery, Length of Stay, Burns, Respiration, Artificial, Algorithms, Early Ambulation, Retrospective Studies
Abstract

Early mobilization with mechanically ventilated patients has received significant attention within recent literature; however, limited research has focused specifically on the burn population. The purpose of this single-center, retrospective analysis was to review the use of a burn critical care mobility algorithm, to determine the safety and feasibility of a burn vented mobility program, share limitations preventing mobility progression at our facility, and discuss unique challenges to vented mobility with intubated burn patients. A retrospective review was completed for all intubated burn center admissions between January 2015 and December 2019. Burn therapy notes were then reviewed for data collection, during the intubation period, using stages of the mobility algorithm. In the 5-year period following initial implementation, the vented mobility algorithm was utilized on 127 patients with an average TBSA of 22.8%. No adverse events occurred. Stage 1 (range of motion) was completed with 100% of patients (n = 127). Chair mode of bed, stage 2a, was utilized in 39.4% (n = 50) of patients, while 15.8% (n = 20) of patients were dependently transferred to the cardiac chair in stage 2b. Stage 3 (sitting on the edge of the bed) was completed with 25% (n = 32) of patients, with 11% (n = 14) progressing to stage 5 (standing), and 3.9% (n = 5) actively transferring to a chair. In the 5 years, only 4.7% (n = 6) reached stage 6 (ambulation). The most common treatment limitations were medical complications (33%) and line placement (21%). Early mobilization during mechanical ventilation is safe and feasible within the burn population, despite challenges, including airway stability, sedation, and line limitations.

Published
2022

38. Stocker du carbone dans les sols agricoles et forestiers ultramarins - Résumé pour décideurs - Etat des connaissances et leviers d'actions dans les départements et régions d'Outre-mer

Author

Demenois, Julien, Daguet, Ellie, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, Roggy, Jean-Christophe, Fujisaki, Kenji, Teste, Adrien, Thongo Mbou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Richard, Antoine, Stahl, Clément, Todoroff, Pierre, Vayssières, Jonathan, Heurtaux, Anne, and Jannoyer, Magalie

Published
2023

39. Etude ' 4 pour 1 000 ' Outre-mer - Stocker du carbone dans les sols agricoles et forestiers ultramarins - Etat des connaissances et leviers d'actions dans les départements et régions d'Outre-mer - Rapport final

Author

Demenois, Julien, Blazy, Jean Marc, Albrecht, Alain, Blanfort, Vincent, Freycon, Vincent, Versini, Antoine, Sierra, Jorge, Roggy, Jean-Christophe, Fujisaki, Kenji, Teste, Adrien, Thongo M'Bou, Armel, Gavazzi, Alma, Ponton, Clara, Moniot, Margot, Acosta-Alba, Ivonne, Montouroy, Yves, Avadi, Angel, Benoist, Anthony, Bréchet, Laëtitia, Chevallier, Tiphaine, Chotte, Jean-Luc, Derroire, Géraldine, Dorel, Marc, Feder, Frédéric, Fernandes, Paula, Ozier-Lafontaine, Harry, Richard, A., Stahl, Clément, Todoroff, Pierre, and Vayssières, Jonathan

Abstract

Coordonnée par le Cirad en partenariat avec INRAE et l'IRD, l'étude ≪ 4 pour 1000 ≫ Outre-mer dresse un bilan inédit des stocks de carbone du sol des territoires ultramarins. Les auteurs formulent des recommandations opérationnelles et de recherche pour preserver ces stocks élevés et répondre aux grands enjeux actuels de l'agriculture face au changement climatique au niveau national et territorial. Si le potentiel des sols métropolitains a fait l'objet d'une evaluation en 2019, celui des territoires ultramarins était jusqu'ici méconnu. Dans le cadre de la présente étude, les auteurs dressent pour la premiere fois un état des lieux des connaissances pour la Guadeloupe, la Martinique, la Guyane, La Reunion, Mayotte, Saint-Martin et Saint-Barthélemy.

Published
2023

40. AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network

Author

Plesa, Adriana, primary, Dumezy, Florent, additional, Mathis, Stéphanie, additional, Lhoumeau, Anne-Catherine, additional, Bardet, Valerie, additional, Saada, Véronique, additional, Arnoux, Isabelle, additional, Badaoui, Bouchra, additional, Cornet, Edouard, additional, Osman, Jennifer, additional, Guerin, Estelle, additional, Chapuis, Nicolas, additional, Genevieve, Franck, additional, Letestu, Rémi, additional, Manzoni, Delphine, additional, Roggy, Anne, additional, Roussel, Mikael, additional, Harrivel, Véronique, additional, Bera, Elsa, additional, Mayeur-Rousse, Caroline, additional, Lapillonne, Hélène, additional, Veyrat-Masson, Richard, additional, Campos, Lydia, additional, Le Garff-Tavernier, Magali, additional, Raskovalova, Tatiana, additional, Vergez, Francois, additional, Guy, Julien, additional, Charpentier, Agnes, additional, Hemar, Claire, additional, Goncalves Monteiro, Valerie, additional, Fegier, Frederic, additional, Celli-Lebras, Karine, additional, Itzykson, Raphael, additional, Dombret, Herve, additional, Preudhomme, Claude, additional, and Roumier, Christophe, additional

Published
2022
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41. Rôle du cytologiste pour orienter le diagnostic d’un syndrome VEXAS

Author

Roggy, Anne, primary, Humbert, Sébastien, additional, Mathieu, Valérie, additional, Puyraimond, Sandrine, additional, Lejarre, Fabien, additional, Renosi, Florian, additional, Duroyon, Eugénie, additional, Golden, Cécile, additional, Magy-Bertrand, Nadine, additional, Deconinck, Eric, additional, and Garnache Ottou, Francine, additional

Published
2022
Full Text
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42. How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Author

Xavier Cahu, Maxime Desmarets, Thibaut Leguay, Philippe Saas, Victoria Raggueneau, Delphine Binda, Maria Alessandra Rosenthal, Chrystelle Vidal, Olivier Adotevi, Fanny Angelot-Delettre, Françoise Solly, Anne-Cécile Galoisy, Alice Garnier, Sylvie Daliphard, Estelle Guérin, Marie-Pierre Gourin, Karim Maloum, Véronique Harrivel, Edouard Cornet, Felipe Suarez, Jacques Vargaftig, Fabrice Jardin, Caroline Mayeur-Rousse, Sylvain Thepot, Maïder Pagadoy, Thorsten Braun, Bernard Drenou, Yuriy Drebit, Marc Maynadié, Caroline Basle, Zehaira Benseddik, Frédéric Féger, Jean Feuillard, Christian Recher, Etienne Lengliné, Catherine Cordonnier, Rémi Letestu, Mathieu Puyade, Isabelle Arnoux, Remy Gressin, Nathalie Contentin, Jerome Tamburini, Pascale Saussoy, Mary Callanan, Elodie Dindinaud, Pierre-Simon Rohrlich, Julien Guy, Hind Bennani, Tony Petrella, Vincent Foissaud, Johann Rose, Natacha Maillard, Lucile Baseggio, Magali Le Garff-Tavernier, Vincent Barlogis, Denis Guyotat, Yohan Desbrosses, Caroline Bonmati, Damien Roos-Weil, Michel Ticchioni, Sandrine Puyraimond, Norbert Vey, Adriana Plesa, Blandine Guffroy, Daniel Lusina, Bérengère Gruson, Anne Roggy, Véronique Salaun, Eric Deconinck, Jean-Yves Cahn, Nathalie Jacques, Caroline Bret, Florian Renosi, Marie-Christine Béné, Alice Eischen, Stefan Wickenhauser, Benjamin Papoular, Francine Garnache-Ottou, François-Xavier Gros, Vahid Asnafi, Celia Salanoubat, Blandine Bénet, Elisabeth Macintyre, Lou Soret, Orianne Wagner-Ballon, Mohamad Mohty, Elsa Bera, Nicolas Freynet, Ludovic Lhermitte, Franck Trimoreau, Claude Preudhomme, Christophe Roumier, Sébastien Maury, Sabrina Bouyer, Eve Poret, Mikael Roussel, Romaric Lacroix, Christine Arnoulet, Françoise Schillinger, Patricia Okamba, Christine Lefebvre, Didier Blaise, Nicolas Lechevalier, Sabine Brechignac, Christophe Ferrand, Estelle Seilles, Richard Veyrat-Masson, Giorgia Battipaglia, Denis Caillot, Véronique Latger-Cannard, Bruno Quesnel, Didier Bouscary, Sophie Brun, Agathe Debliquis, Marie Loosveld, Franck Geneviève, Carinne Lafon, Lydia Campos, Thierry Fest, Ouda Ghoual, Marie-Christine Jacob, Pierre Peterlin, Valérie Bardet, Anne Arnaud, Véronique Dorvaux, Sabeha Biichle, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), ANR-11-LABX-0024,ParaFrap,Alliance française contre les maladies parasitaires(2011), European Project: IC18CT980373, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biologie hématologique, Garnache-Ottou, F., Vidal, C., Biichle, S., Renosi, F., Poret, E., Pagadoy, M., Desmarets, M., Roggy, A., Seilles, E., Soret, L., Schillinger, F., Puyraimond, S., Petrella, T., Preudhomme, C., Roumier, C., Macintyre, E. A., Harrivel, V., Desbrosses, Y., Gruson, B., Genevieve, F., Thepot, S., Drebit, Y., Leguay, T., Gros, F. -X., Lechevalier, N., Saussoy, P., Salaun, V., Cornet, E., Benseddik, Z., Veyrat-Masson, R., Wagner-Ballon, O., Salanoubat, C., Maynadie, M., Guy, J., Caillot, D., Jacob, M. -C., Cahn, J. -Y., Gressin, R., Rose, J., Quesnel, B., Guerin, E., Trimoreau, F., Feuillard, J., Gourin, M. -P., Plesa, A., Baseggio, L., Arnoux, I., Vey, N., Blaise, D., Lacroix, R., Arnoulet, C., Benet, B., Dorvaux, V., Bret, C., Drenou, B., Debliquis, A., Latger-Cannard, V., Bonmati, C., Bene, M. -C., Peterlin, P., Ticchioni, M., Rohrlich, P. -S., Arnaud, A., Wickenhauser, S., Bardet, V., Brechignac, S., Papoular, B., Raggueneau, V., Vargaftig, J., Letestu, R., Lusina, D., Braun, T., Foissaud, V., Tamburini, J., Bennani, H., Freynet, N., Cordonnier, C., Le Garff-Tavernier, M., Jacques, N., Maloum, K., Roos-Weil, D., Bouscary, D., Asnafi, V., Lhermitte, L., Suarez, F., Lengline, E., Feger, F., Battipaglia, G., Mohty, M., Bouyer, S., Ghoual, O., Dindinaud, E., Basle, C., Puyade, M., Lafon, C., Fest, T., Roussel, M., Cahu, X., Bera, E., Daliphard, S., Jardin, F., Campos, L., Solly, F., Guyotat, D., Galoisy, A. -C., Eischen, A., Mayeur-Rousse, C., Guffroy, B., Recher, C., Loosveld, M., Garnier, A., Barlogis, V., Rosenthal, M. A., Brun, S., Contentin, N., Maury, S., Callanan, M., Lefebvre, C., Maillard, N., Okamba, P., Ferrand, C., Adotevi, O., Saas, P., Angelot-Delettre, F., Binda, D., and Deconinck, E.

Subjects
Oncology, Vincristine, medicine.medical_specialty, Myeloid, Cyclophosphamide, Clinical Trials and Observations, medicine.medical_treatment, [SDV.CAN]Life Sciences [q-bio]/Cancer, Hematopoietic stem cell transplantation, Plasmacytoid dendritic cell, Immunophenotyping, Clonal Evolution, 03 medical and health sciences, 0302 clinical medicine, Bone Marrow, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Neoplasm Metastasis, Neoplasm Staging, 030304 developmental biology, Chromosome Aberrations, 0303 health sciences, Leukemia, business.industry, Hematopoietic Stem Cell Transplantation, Disease Management, Myeloid leukemia, Dendritic Cells, Hematology, Prognosis, medicine.disease, Blood Cell Count, 3. Good health, Transplantation, Treatment Outcome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Acute Disease, business, Biomarkers, medicine.drug
Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed a nationwide network to collect data from new cases diagnosed in France. In a retrospective, observational study of 86 patients (2000-2013), we described clinical and biological data focusing on morphologies and immunophenotype. We found expression of markers associated with plasmacytoid dendritic cell origin (HLA-DRhigh, CD303+, CD304+, and cTCL1+) plus CD4 and CD56 and frequent expression of isolated markers from the myeloid, B-, and T-lymphoid lineages, whereas specific markers (myeloperoxidase, CD14, cCD3, CD19, and cCD22) were not expressed. Fifty-one percent of cytogenetic abnormalities impact chromosomes 13, 12, 9, and 15. Myelemia was associated with an adverse prognosis. We categorized chemotherapeutic regimens into 5 groups: acute myeloid leukemia (AML)–like, acute lymphoid leukemia (ALL)–like, lymphoma (cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP])–like, high-dose methotrexate with asparaginase (Aspa-MTX) chemotherapies, and not otherwise specified (NOS) treatments. Thirty patients received allogeneic hematopoietic cell transplantation (allo-HCT), and 4 patients received autologous hematopoietic cell transplantation. There was no difference in survival between patients receiving AML-like, ALL-like, or Aspa-MTX regimens; survival was longer in patients who received AML-like, ALL-like, or Aspa-MTX regimens than in those who received CHOP-like regimens or NOS. Eleven patients are in persistent complete remission after allo-HCT with a median survival of 49 months vs 8 for other patients. Our series confirms a high response rate with a lower toxicity profile with the Aspa-MTX regimen, offering the best chance of access to hematopoietic cell transplantation and a possible cure.

Published
2019

43. Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis

Author

Christophe Ferrand, Philippe Saas, Etienne Daguindau, Anne Roggy, Sandrine Geffroy, Sabrina Bouyer, Pierre-Julien Viailly, Olivier Adotevi, Mary Callanan, Sabeha Biichle, Elizabeth Macintyre, Francine Garnache-Ottou, Tony Petrella, Jacques Colinge, Christophe Roumier, Florian Renosi, Véronique Harrivel, Véronique Salaun, Pascale Saussoy, Eric Deconinck, Ambre Giguelay, Fanny Angelot-Delettre, Jean Feuillard, Vahid Asnafi, Claude Preudhomme, Fabrice Jardin, Meyling Cheok, Pascal Fuseau, Lou Soret, UCL - (SLuc) Service de biologie hématologique, and UCL - SSS/IREC/SLUC - Pôle St.-Luc

Subjects
Myeloid, Carcinogenesis, Plasmacytoid dendritic cell, Biology, medicine.disease_cause, SOXC Transcription Factors, Immunophenotyping, CDKN2A, medicine, Humans, Lectins, C-Type, Receptors, Immunologic, Acute leukemia, Myeloid Neoplasia, Membrane Glycoproteins, Myeloproliferative Disorders, Dendritic Cells, Genomics, Hematology, ETV6, medicine.anatomical_structure, Cancer research, Transcriptome, SNP array
Abstract

Oncogenesis and ontogeny of blastic plasmacytoid dendritic cell neoplasm (BPDCN) remain uncertain, between canonical plasmacytoid dendritic cells (pDCs) and AXL+ SIGLEC6+ DCs (AS-DCs). We compared 12 BPDCN to 164 acute leukemia by Affymetrix HG-U133 Plus 2.0 arrays: BPDCN were closer to B-cell acute lymphoblastic leukemia (ALL), with enrichment in pDC, B-cell signatures, vesicular transport, deubiquitination pathways, and AS-DC signatures, but only in some cases. Importantly, 1 T-cell ALL clustered with BPDCN, with compatible morphology, immunophenotype (cCD3+ sCD3− CD123+ cTCL1+ CD304+), and genetics. Many oncogenetic pathways are deregulated in BPDCN compared with normal pDC, such as cell-cycle kinases, and importantly, the transcription factor SOX4, involved in B ontogeny, pDC ontogeny, and cancer cell invasion. High-throughput sequencing (HaloPlex) showed myeloid mutations (TET2, 62%; ASXL1, 46%; ZRSR2, 31%) associated with lymphoid mutations (IKZF1), whereas single-nucleotide polymorphism (SNP) array (Affymetrix SNP array 6.0) revealed frequent losses (mean: 9 per patient) involving key hematological oncogenes (RB1, IKZF1/2/3, ETV6, NR3C1, CDKN2A/B, TP53) and immune response genes (IFNGR, TGFB, CLEC4C, IFNA cluster). Various markers suggest an AS-DC origin, but not in all patients, and some of these abnormalities are related to the leukemogenesis process, such as the 9p deletion, leading to decreased expression of genes encoding type I interferons. In addition, the AS-DC profile is only found in a subgroup of patients. Overall, the cellular ontogenic origin of BPDCN remains to be characterized, and these results highlight the heterogeneity of BPDCN, with a risk of a diagnostic trap.

Published
2021

45. 562 Therapy Resources for Management of Large TBSA Burns: A Case Study

Author

Audrey O'Neil, Cassandra Rush, David Roggy, and Brett Hartman

Subjects
Rehabilitation, Emergency Medicine, Surgery
Abstract

Introduction Therapy studies involving large percent TBSA burns ( >50% TBSA) are not well described. Studies show the highest predictor of preventing burn scar contracture is the amount of burn rehabilitation time received per cutaneous functional units involved, but what does “more therapy time” mean for larger burns in terms of therapy resources for burn centers? Methods A case study was completed on a 20-year-old male admitted after sustaining 85% TBSA full thickness flame burns to his face, neck, arms, legs, and trunk, along with an inhalation injury. He was admitted to the inpatient burn ICU for 113 days, undergoing 16 surgeries to achieve skin coverage prior to discharge to acute rehab. Therapy was initiated < 24 hours after admission to the Burn ICU. Direct therapy contact minutes were tracked during all session and divided into therapy treatment domains. (resource). If co-treating occurred, a single unit of time was used for the time of the session to avoid doubling the units provided. Results Therapy occurred on 106/113 days of admission, receiving 238 therapy sessions (113 PT, 125 OT). He received 21,027 minutes of direct therapy, averaging 196.5 min/rehab days. The highest number of therapy minutes were spent on ROM (9,032 min). Other domains of care included Mobilization (3,171 min), Positioning (2,298 min), Orthotic management (1,326 min), etc. (Table 1). Despite focus on ROM and positioning, he discharged with 7 moderate (left wrist extension, bilateral hip abduction, bilateral ankle dorsiflexion, left neck rotation, and left forearm supination) and 4 severe contractures (right wrist extension, bilateral hip extension, neck extension). He was able to transfer with moderate assistance and walk 150 ft with a platform walker at discharge. Conclusions Therapy interventions in the literature are often described in isolated “domains” of practice, however guidelines on a global approach to management of those with catastrophic injuries does not exist. Prioritization between domains with limited therapy resources when facing patients with extensive deficits is challenging. A dedicated burn therapy staff with availability to secure additional resources was required to ensure optimal outcomes in the management of this patient Applicability of Research to Practice This case study demonstrates the comprehensive burden of care and need for additional therapy resources in the management large TBSA burns.

Published
2023

46. 511 Mobilization with Femoral Catheters in the Burn Intensive Care Unit: A Case Series

Author

Audrey O'Neil, Cassandra Rush, David Roggy, and Brett Hartman

Subjects
Rehabilitation, Emergency Medicine, Surgery
Abstract

Introduction Femoral catheters are a known barrier for ICU therapy sessions and mobility progression due to the anatomical location and potential risk of complications. Safety and feasibility of mobilization has been studied in ICU populations but has not been explored specifically within the burn population. Burn survivors in the ICU have challenges in terms of line access and are at high risk of complications concerning thrombosis A previous retrospective study found that 21% of mobility sessions within the burn ICU on vented patients were limited due to line limitations. This case review was completed following implementation of new mobility guidelines allowing the mobilization of patients with femoral catheters within the burn ICU. Methods This retrospective case series was completed in the first year following implementation of new femoral catheter mobility guidelines within a 15-bed adult burn unit. Burn therapy notes were reviewed for burn admissions with at least one femoral catheter in place, including arterial and central lines. Mobility was recorded based on achieved activity levels achieved during each session. Passive interventions (stretching, ROM, and positioning) were excluded. Results 13 patients were admitted with a total of 55 femoral catheters (8 arterial, 46 central venous) treated. Patients were seen by PT and OT for a combined 417 sessions with lines in place. A total of 65 active therapy sessions occurred with 112 mobility activities including bed exercises/cycle ergometry (11), chair mode (13), cardiac chair transfer (28), tilt table (1), sitting on the side of the bed (32), standing (15), active chair transfers (8), and ambulation (4). No catheter related complications including catheter malfunctions, removal, bleeding, or thrombosis occurred during any therapy sessions. Conclusions Active therapy sessions including out of bed activities are safe and feasible in burn ICU patients with femoral catheters. Early mobilization within ICU settings is necessary in preventing complications, combating muscle wasting, and improving long term outcomes for survivors. This study supports that the presence of femoral catheters alone should not limit the progression of mobility interventions. Applicability of Research to Practice Using clinical judgement and specialty training, burn therapists can safely mobilize burn ICU patients with femoral catheters in place.

Published
2023

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