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2. Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis

Author

Renosi, Florian, Roggy, Anne, Giguelay, Ambre, Soret, Lou, Viailly, Pierre-Julien, Cheok, Meyling, Biichle, Sabeha, Angelot-Delettre, Fanny, Asnafi, Vahid, Macintyre, Elizabeth, Geffroy, Sandrine, Callanan, Mary, Petrella, Tony, Deconinck, Eric, Daguindau, Etienne, Harrivel, Véronique, Bouyer, Sabrina, Salaun, Véronique, Saussoy, Pascale, Feuillard, Jean, Fuseau, Pascal, Saas, Philippe, Adotévi, Olivier, Jardin, Fabrice, Ferrand, Christophe, Preudhomme, Claude, Colinge, Jacques, Roumier, Christophe, and Garnache-Ottou, Francine

Published
2021
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3. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Author

Bond, Jonathan, Krzywon, Aleksandra, Lhermitte, Ludovic, Roumier, Christophe, Roggy, Anne, Belhocine, Mohamed, Kheirallah, Alexander Abdulkader, Villarese, Patrick, Hypolite, Guillaume, Garnache-Ottou, Francine, Castaigne, Sylvie, Boissel, Nicolas, Asnafi, Vahid, Preudhomme, Claude, Dombret, Hervé, Laurenti, Elisa, and Macintyre, Elizabeth

Published
2021
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4. How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Author

Garnache-Ottou, Francine, Vidal, Chrystelle, Biichlé, Sabeha, Renosi, Florian, Poret, Eve, Pagadoy, Maïder, Desmarets, Maxime, Roggy, Anne, Seilles, Estelle, Soret, Lou, Schillinger, Françoise, Puyraimond, Sandrine, Petrella, Tony, Preudhomme, Claude, Roumier, Christophe, MacIntyre, Elisabeth A., Harrivel, Véronique, Desbrosses, Yohan, Gruson, Bérengère, Geneviève, Franck, Thepot, Sylvain, Drebit, Yuriy, Leguay, Thibaut, Gros, François-Xavier, Lechevalier, Nicolas, Saussoy, Pascale, Salaun, Véronique, Cornet, Edouard, Benseddik, Zehaira, Veyrat-Masson, Richard, Wagner-Ballon, Orianne, Salanoubat, Célia, Maynadié, Marc, Guy, Julien, Caillot, Denis, Jacob, Marie-Christine, Cahn, Jean-Yves, Gressin, Rémy, Rose, Johann, Quesnel, Bruno, Guerin, Estelle, Trimoreau, Franck, Feuillard, Jean, Gourin, Marie-Pierre, Plesa, Adriana, Baseggio, Lucile, Arnoux, Isabelle, Vey, Norbert, Blaise, Didier, Lacroix, Romaric, Arnoulet, Christine, Benet, Blandine, Dorvaux, Véronique, Bret, Caroline, Drenou, Bernard, Debliquis, Agathe, Latger-Cannard, Véronique, Bonmati, Caroline, Bene, Marie-Christine, Peterlin, Pierre, Ticchioni, Michel, Rohrlich, Pierre-Simon, Arnaud, Anne, Wickenhauser, Stefan, Bardet, Valérie, Brechignac, Sabine, Papoular, Benjamin, Raggueneau, Victoria, Vargaftig, Jacques, Letestu, Rémi, Lusina, Daniel, Braun, Thorsten, Foissaud, Vincent, Tamburini, Jérôme, Bennani, Hind, Freynet, Nicolas, Cordonnier, Catherine, Le Garff-Tavernier, Magali, Jacques, Nathalie, Maloum, Karim, Roos-Weil, Damien, Bouscary, Didier, Asnafi, Vahid, Lhermitte, Ludovic, Suarez, Felipe, Lengline, Etienne, Féger, Frédéric, Battipaglia, Giorgia, Mohty, Mohamad, Bouyer, Sabrina, Ghoual, Ouda, Dindinaud, Elodie, Basle, Caroline, Puyade, Mathieu, Lafon, Carinne, Fest, Thierry, Roussel, Mikael, Cahu, Xavier, Bera, Elsa, Daliphard, Sylvie, Jardin, Fabrice, Campos, Lydia, Solly, Françoise, Guyotat, Denis, Galoisy, Anne-Cécile, Eischen, Alice, Mayeur-Rousse, Caroline, Guffroy, Blandine, Recher, Christian, Loosveld, Marie, Garnier, Alice, Barlogis, Vincent, Rosenthal, Maria Alessandra, Brun, Sophie, Contentin, Nathalie, Maury, Sébastien, Callanan, Mary, Lefebvre, Christine, Maillard, Natacha, Okamba, Patricia, Ferrand, Christophe, Adotevi, Olivier, Saas, Philippe, Angelot-Delettre, Fanny, Binda, Delphine, and Deconinck, Eric

Published
2019
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6. Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

Author

Emadali, Anouk, Hoghoughi, Neda, Duley, Samuel, Hajmirza, Azadeh, Verhoeyen, Els, Cosset, Francois-Loic, Bertrand, Philippe, Roumier, Christophe, Roggy, Anne, Suchaud-Martin, Céline, Chauvet, Martine, Bertrand, Sarah, Hamaidia, Sieme, Rousseaux, Sophie, Josserand, Véronique, Charles, Julie, Templier, Isabelle, Maeda, Takahiro, Bruder-Costa, Juliana, Chaperot, Laurence, Plumas, Joel, Jacob, Marie-Christine, Bonnefoix, Thierry, Park, Sophie, Gressin, Remy, Tensen, Cornelis P., Mecucci, Cristina, Macintyre, Elizabeth, Leroux, Dominique, Brambilla, Elisabeth, Nguyen-Khac, Florence, Luquet, Isabelle, Penther, Dominique, Bastard, Christian, Jardin, Fabrice, Lefebvre, Christine, Garnache, Francine, and Callanan, Mary B.

Published
2016
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7. AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network

Author

Plesa, Adriana, primary, Dumezy, Florent, additional, Mathis, Stéphanie, additional, Lhoumeau, Anne-Catherine, additional, Bardet, Valerie, additional, Saada, Véronique, additional, Arnoux, Isabelle, additional, Badaoui, Bouchra, additional, Cornet, Edouard, additional, Osman, Jennifer, additional, Guerin, Estelle, additional, Chapuis, Nicolas, additional, Genevieve, Franck, additional, Letestu, Rémi, additional, Manzoni, Delphine, additional, Roggy, Anne, additional, Roussel, Mikael, additional, Harrivel, Véronique, additional, Bera, Elsa, additional, Mayeur-Rousse, Caroline, additional, Lapillonne, Hélène, additional, Veyrat-Masson, Richard, additional, Campos, Lydia, additional, Le Garff-Tavernier, Magali, additional, Raskovalova, Tatiana, additional, Vergez, Francois, additional, Guy, Julien, additional, Charpentier, Agnes, additional, Hemar, Claire, additional, Goncalves Monteiro, Valerie, additional, Fegier, Frederic, additional, Celli-Lebras, Karine, additional, Itzykson, Raphael, additional, Dombret, Herve, additional, Preudhomme, Claude, additional, and Roumier, Christophe, additional

Published
2022
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8. Rôle du cytologiste pour orienter le diagnostic d’un syndrome VEXAS

Author

Roggy, Anne, primary, Humbert, Sébastien, additional, Mathieu, Valérie, additional, Puyraimond, Sandrine, additional, Lejarre, Fabien, additional, Renosi, Florian, additional, Duroyon, Eugénie, additional, Golden, Cécile, additional, Magy-Bertrand, Nadine, additional, Deconinck, Eric, additional, and Garnache Ottou, Francine, additional

Published
2022
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9. Case Report: Evolution of a Severe Vascular Refractory Form of ECD Requiring Liver Transplantation Correlated With the Change in the Monocyte Subset Analysis

Author

Razanamahery, Jérôme, primary, Roggy, Anne, additional, Emile, Jean-François, additional, Malakhia, Alexandre, additional, Lakkis, Zaher, additional, Garnache-Ottou, Francine, additional, Soumagne, Thibaud, additional, Cohen-Aubart, Fleur, additional, Haroche, Julien, additional, and Bonnotte, Bernard, additional

Published
2021
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10. Lymphoblastic T Cells and Mature NK Cells With the Same TCRγ Rearrangement: A Common Origin?

Author

Roggy, Anne, primary, Biichle, Sabeha, additional, Ferrand, Christophe, additional, Renosi, Florian, additional, Larosa, Fabrice, additional, Deconinck, Eric, additional, Daguindeau, Etienne, additional, Collonge Rame, Marie-Agnes, additional, Schillinger, Françoise, additional, Seilles, Estelle, additional, and Garnache-Ottou, Francine, additional

Published
2021
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11. Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis.

Author

UCL - (SLuc) Service de biologie hématologique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Renosi, Florian, Roggy, Anne, Giguelay, Ambre, Soret, Lou, Viailly, Pierre-Julien, Cheok, Meyling, Biichle, Sabeha, Angelot-Delettre, Fanny, Asnafi, Vahid, Macintyre, Elizabeth, Geffroy, Sandrine, Callanan, Mary, Petrella, Tony, Deconinck, Eric, Daguindau, Etienne, Harrivel, Véronique, Bouyer, Sabrina, Salaun, Véronique, Saussoy, Pascale, Feuillard, Jean, Fuseau, Pascal, Saas, Philippe, Adotévi, Olivier, Jardin, Fabrice, Ferrand, Christophe, Preudhomme, Claude, Colinge, Jacques, Roumier, Christophe, Garnache-Ottou, Francine, UCL - (SLuc) Service de biologie hématologique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Renosi, Florian, Roggy, Anne, Giguelay, Ambre, Soret, Lou, Viailly, Pierre-Julien, Cheok, Meyling, Biichle, Sabeha, Angelot-Delettre, Fanny, Asnafi, Vahid, Macintyre, Elizabeth, Geffroy, Sandrine, Callanan, Mary, Petrella, Tony, Deconinck, Eric, Daguindau, Etienne, Harrivel, Véronique, Bouyer, Sabrina, Salaun, Véronique, Saussoy, Pascale, Feuillard, Jean, Fuseau, Pascal, Saas, Philippe, Adotévi, Olivier, Jardin, Fabrice, Ferrand, Christophe, Preudhomme, Claude, Colinge, Jacques, Roumier, Christophe, and Garnache-Ottou, Francine

Abstract

Oncogenesis and ontogeny of blastic plasmacytoid dendritic cell neoplasm (BPDCN) remain uncertain, between canonical plasmacytoid dendritic cells (pDCs) and AXL+ SIGLEC6+ DCs (AS-DCs). We compared 12 BPDCN to 164 acute leukemia by Affymetrix HG-U133 Plus 2.0 arrays: BPDCN were closer to B-cell acute lymphoblastic leukemia (ALL), with enrichment in pDC, B-cell signatures, vesicular transport, deubiquitination pathways, and AS-DC signatures, but only in some cases. Importantly, 1 T-cell ALL clustered with BPDCN, with compatible morphology, immunophenotype (cCD3+ sCD3- CD123+ cTCL1+ CD304+), and genetics. Many oncogenetic pathways are deregulated in BPDCN compared with normal pDC, such as cell-cycle kinases, and importantly, the transcription factor SOX4, involved in B ontogeny, pDC ontogeny, and cancer cell invasion. High-throughput sequencing (HaloPlex) showed myeloid mutations (TET2, 62%; ASXL1, 46%; ZRSR2, 31%) associated with lymphoid mutations (IKZF1), whereas single-nucleotide polymorphism (SNP) array (Affymetrix SNP array 6.0) revealed frequent losses (mean: 9 per patient) involving key hematological oncogenes (RB1, IKZF1/2/3, ETV6, NR3C1, CDKN2A/B, TP53) and immune response genes (IFNGR, TGFB, CLEC4C, IFNA cluster). Various markers suggest an AS-DC origin, but not in all patients, and some of these abnormalities are related to the leukemogenesis process, such as the 9p deletion, leading to decreased expression of genes encoding type I interferons. In addition, the AS-DC profile is only found in a subgroup of patients. Overall, the cellular ontogenic origin of BPDCN remains to be characterized, and these results highlight the heterogeneity of BPDCN, with a risk of a diagnostic trap.

Published
2021

12. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Author

Bond, Jonathan, primary, Krzywon, Aleksandra, additional, Lhermitte, Ludovic, additional, Roumier, Christophe, additional, Roggy, Anne, additional, Belhocine, Mohamed, additional, Kheirallah, Alexander Abdulkader, additional, Villarese, Patrick, additional, Hypolite, Guillaume, additional, Garnache-Ottou, Francine, additional, Castaigne, Sylvie, additional, Boissel, Nicolas, additional, Asnafi, Vahid, additional, Preudhomme, Claude, additional, Dombret, Hervé, additional, Laurenti, Elisa, additional, and Macintyre, Elizabeth, additional

Published
2020
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13. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Author

Bond, Jonathan, primary, Krzywon, Aleksandra, additional, Lhermitte, Ludovic, additional, Roumier, Christophe, additional, Roggy, Anne, additional, Belhocine, Mohamed, additional, Kheirallah, Alexander Kaden, additional, Villarese, Patrick, additional, Hypolite, Guillaume, additional, Garnache-Ottou, Francine, additional, Castaigne, Sylvie, additional, Boissel, Nicolas, additional, Asnafi, Vahid, additional, Preudhomme, Claude, additional, Dombret, Hervé, additional, Laurenti, Elisa, additional, and Macintyre, Elizabeth, additional

Published
2019
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14. A Transcriptomic Continuum of Differentiation Arrest in Acute Leukemia

Author

Bond, Jonathan, primary, Krzywon, Aleksandra, additional, Lhermitte, Ludovic, additional, Roumier, Christophe, additional, Roggy, Anne, additional, Belhocine, Mohamed, additional, Kheirallah, Alexander, additional, Villarese, Patrick, additional, Hypolite, Guillaume, additional, Garnache-Ottou, Francine, additional, Dombret, Herve, additional, Boissel, Nicolas, additional, Preudhomme, Claude, additional, Asnafi, Vahid, additional, Laurenti, Elisa, additional, and Macintyre, Elizabeth, additional

Published
2019
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15. Standardization of Flow Cytometric Immunophenotyping for Hematological Malignancies: The FranceFlow Group Experience.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Département de pharmacie, Solly, Françoise, Angelot-Delettre, Fanny, Ticchioni, Michel, Geneviève, Franck, Rambaud, Hubert, Baseggio, Lucile, Plesa, Adriana, Debliquis, Agathe, Garnache-Ottou, Francine, Roggy, Anne, Campos, Lydia, Aanei, Carmen, Rosenthal-Allieri, Alessandra, Georget, Marie-Thérèse, Lachot, Sébastien, Jacob, Marie-Christine, Robillard, Nelly, Wuilleme, Soraya, Andre-Kerneis, Elisabeth, Cornet, Edouard, Salaun, Véronique, Bennami, Hind, Lhoumeau, Anne-Catherine, Arnoulet, Christine, JACQMIN, Hugues, NEYMAN, Nicolas, Latger-Cannard, Véronique, Massin, Fredéric, Lainey, Elodie, Le Garff-Tavernier, Magali, Costopoulos, Myrto, Roussel, Mickael, Mayeur-Rousse, Caroline, Eischen, Alice, Raggeneau, Victoria, Derrieux, Coralie, Maurer, Maxime, Asnafi, Vahid, Trinquand, Amélie, Brouzes, Chantal, Lhermitte, Ludovic, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Département de pharmacie, Solly, Françoise, Angelot-Delettre, Fanny, Ticchioni, Michel, Geneviève, Franck, Rambaud, Hubert, Baseggio, Lucile, Plesa, Adriana, Debliquis, Agathe, Garnache-Ottou, Francine, Roggy, Anne, Campos, Lydia, Aanei, Carmen, Rosenthal-Allieri, Alessandra, Georget, Marie-Thérèse, Lachot, Sébastien, Jacob, Marie-Christine, Robillard, Nelly, Wuilleme, Soraya, Andre-Kerneis, Elisabeth, Cornet, Edouard, Salaun, Véronique, Bennami, Hind, Lhoumeau, Anne-Catherine, Arnoulet, Christine, JACQMIN, Hugues, NEYMAN, Nicolas, Latger-Cannard, Véronique, Massin, Fredéric, Lainey, Elodie, Le Garff-Tavernier, Magali, Costopoulos, Myrto, Roussel, Mickael, Mayeur-Rousse, Caroline, Eischen, Alice, Raggeneau, Victoria, Derrieux, Coralie, Maurer, Maxime, Asnafi, Vahid, Trinquand, Amélie, Brouzes, Chantal, and Lhermitte, Ludovic

Abstract

Flow cytometry is broadly used for the identification, characterization, and monitoring of hematological malignancies. However, the use of clinical flow cytometry is restricted by its lack of reproducibility across multiple centers. Since 2006, the EuroFlow consortium has been developing a standardized procedure detailing the whole process from instrument settings to data analysis. The FranceFlow group was created in 2010 with the intention to educate participating centers in France about the standardized instrument setting protocol (SOP) developed by the EuroFlow consortium and to organise several rounds of quality controls (QCs) in order to evaluate the feasibility of its application and its results. Here, we report the 5 year experience of the FranceFlow group and the results of the seven QCs of 23 instruments, involving up to 19 centers, in France and in Belgium. The FranceFlow group demonstrates that both the distribution and applicability of the SOP have been successful. Intercenter reproducibility was evaluated using both normal and pathological blood samples. Coefficients of variation (CVs) across the centers were <7% for the percentages of cell subsets and <30% for the median fluorescence intensities (MFIs) of the markers tested. Intracenter reproducibility provided similar results with CVs of <3% for the percentages of the majority of cell subsets, and CVs of <20% for the MFI values for the majority of markers. Altogether, the FranceFlow group show that the 19 participating labs might be considered as one unique laboratory with 23 identical flow cytometers able to reproduce identical results. Therefore, SOP significantly improves reproducibility of clinical flow in hematology and opens new avenues by providing a robust companion diagnostic tool for clinical trials in hematology. © 2019 International Society for Advancement of Cytometry.

Published
2019

16. Standardization of Flow Cytometric Immunophenotyping for Hematological Malignancies: The FranceFlow Group Experience

Author

Solly, Françoise, primary, Angelot‐Delettre, Fanny, additional, Ticchioni, Michel, additional, Geneviève, Franck, additional, Rambaud, Hubert, additional, Baseggio, Lucile, additional, Plesa, Adriana, additional, Debliquis, Agathe, additional, Garnache‐Ottou, Francine, additional, Roggy, Anne, additional, Campos, Lydia, additional, Aanei, Carmen, additional, Rosenthal‐Allieri, Alessandra, additional, Georget, Marie‐Thérèse, additional, Lachot, Sébastien, additional, Jacob, Marie‐Christine, additional, Robillard, Nelly, additional, Wuilleme, Soraya, additional, Andre‐Kerneis, Elisabeth, additional, Cornet, Edouard, additional, Salaun, Véronique, additional, Bennami, Hind, additional, Lhoumeau, Anne‐Catherine, additional, Arnoulet, Christine, additional, Jacqmin, Hugues, additional, Neyman, Nicolas, additional, Latger‐Cannard, Véronique, additional, Massin, Fredéric, additional, Lainey, Elodie, additional, Le Garff‐Tavernier, Magali, additional, Costopoulos, Myrto, additional, Roussel, Mickael, additional, Mayeur‐Rousse, Caroline, additional, Eischen, Alice, additional, Raggeneau, Victoria, additional, Derrieux, Coralie, additional, Maurer, Maxime, additional, Asnafi, Vahid, additional, Trinquand, Amélie, additional, Brouzes, Chantal, additional, and Lhermitte, Ludovic, additional

Published
2019
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17. Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening

Author

Daix, Thomas, primary, Guerin, Estelle, additional, Tavernier, Elsa, additional, Mercier, Emmanuelle, additional, Gissot, Valérie, additional, Hérault, Olivier, additional, Mira, Jean-Paul, additional, Dumas, Florence, additional, Chapuis, Nicolas, additional, Guitton, Christophe, additional, Béné, Marie C., additional, Quenot, Jean-Pierre, additional, Tissier, Cindy, additional, Guy, Julien, additional, Piton, Gaël, additional, Roggy, Anne, additional, Muller, Grégoire, additional, Legac, Éric, additional, de Prost, Nicolas, additional, Khellaf, Mehdi, additional, Wagner-Ballon, Orianne, additional, Coudroy, Rémi, additional, Dindinaud, Elodie, additional, Uhel, Fabrice, additional, Roussel, Mikaël, additional, Lafon, Thomas, additional, Jeannet, Robin, additional, Vargas, Frédéric, additional, Fleureau, Catherine, additional, Roux, Mickaël, additional, Allou, Kaoutar, additional, Vignon, Philippe, additional, Feuillard, Jean, additional, François, Bruno, additional, Di Vittorio, Adollës, additional, Lachot, Sébastien, additional, Georget, Marie-Thérèse, additional, Hanna, Joelle, additional, Bretonnière, Cédric, additional, Zambon, Olivier, additional, Nicolet, Laurent, additional, Brule, Noëlle, additional, Debord, Camille, additional, Le Bris, Yannick, additional, Robillard, Nelly, additional, Dargent, Auguste, additional, Bretagnol, Anne, additional, Mathonnet, Armelle, additional, Boulain, Thierry, additional, Barbier, François, additional, Benzekri, Dalila, additional, Runge, Isabelle, additional, Kamel, Toufik, additional, Cecchini, Jérôme, additional, Bouyer, Sabrina, additional, Robert, René, additional, and Ouattara, Alexandre, additional

Published
2018
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19. Combination Chemotherapy in Patients with Newly Diagnosed Blastic Plasmacytoid Dendritic Cell Neoplasms (BPDCN): First Results of a Prospective French Trial (LpDessai)

Author

Deconinck, Eric, Gruson, Berengere, Biichle, Sabeha, Roggy, Anne, Renosi, Florian, Fournet, Thomas, Desmarets, Maxime, Tio, Gregory, Marchand, Tony, Roussel, Mikael, Leguay, Thibaut, Vial, Jean-Philippe, Huguet, Francoise, Vergez, Francois, Chalayer, Emilie, Mahfoudi, Khaoula, Honeyman, Fressia, Maury, Sebastien, Freynet, Nicolas, Bonmati, Caroline, Latger-Cannard, Veronique, Gehlkopf, Eve, Bret, Caroline, Roos Weil, Damien, Le Garff-Tavernier, Magali, Rigaudeau, Sophie, Damaj, Gandhi Laurent, Cornet, Edouard, Gressin, Remy, Jacob, Marie-Christine, Martineau, Delphine, Mimoun, Aguirre, Garnier, Alice, Eveillard, Marion, Villate, Alban, Rault, Emmanuelle, Delettre, Fanny, and Garnache Ottou, Francine

Abstract

Introduction

Published
2023
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20. Liver X Receptor Agonists: A Potential Treatment for Blastic Plasmacytoid Dendritic Cell Neoplasm

Author

Ceroi, Adam, primary, Garnache-ottou, Francine, additional, Roggy, Anne, additional, Angelot-Delettre, Fanny, additional, Philippe, Laure, additional, Asgarova, Afag, additional, Bonnefoy, Francis, additional, Chagué, Cécile, additional, Biichle, Sabeha, additional, Remy-Martin, Jean-Paul, additional, Preudhomme, Claude, additional, Roumier, Christophe, additional, Macintyre, Elizabeth, additional, Lagrost, Laurent, additional, Masson, David, additional, and Saas, Philippe, additional

Published
2015
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21. How to Treat Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Patients : Results on 86 Patients of the French BPDCN Network

Author

Poret, Eve, primary, Vidal, Chrystelle, additional, Desbrosses, Yohan, additional, Angelot Delettre, Fanny, additional, Pagadoy, Maider, additional, Pugin, Aurore, additional, Benazet, Louis, additional, Leroux, Franck, additional, Robert, Elise, additional, Binda, Delphine, additional, Biichle, Sabeha, additional, Roggy, Anne, additional, Philippe, Laure, additional, Gruson, Berengere, additional, Gac, Anne-Claire, additional, Maigre, Michel, additional, Caillot, Denis, additional, Gressin, Remy, additional, Turlure, Pascal, additional, Michallet, Anne-Sophie, additional, Gilis, Lila, additional, Dorvaux, Veronique, additional, Arkam, Yazid, additional, Bonmati, Caroline, additional, Péterlin, Pierre, additional, Rohrlich, Pierre-Simon, additional, Braun, Thorsten, additional, Malfuson, jean-Valere, additional, Bouscary, Didier, additional, Pujade-Lauraine, Eric, additional, Suarez, Felipe, additional, Soussain, Carole, additional, Lengliné, Etienne, additional, Puyade, Mathieu, additional, Marchand, Tony, additional, Guyotat, Denis, additional, Lioure, Bruno, additional, Recher, Christian, additional, Roos-Weil, Damien, additional, Jardin, Fabrice, additional, Marolleau, Jean-Pierre, additional, Drenou, Bernard, additional, Bonnotte, Bernard, additional, Dalac, Sophie, additional, Saas, Philippe, additional, Garnache Ottou, Francine, additional, and Deconinck, Eric, additional

Published
2015
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22. SET-NUP214 is a recurrent γδ lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALL.

Author

Abdelali, Raouf Ben, Roggy, Anne, Leguay, Thibaut, Cieslak, Agata, Renneville, Aline, Touzart, Aurore, Banos, Anne, Randriamalala, Edouard, Caillot, Denis, Lioure, Bruno, Devidas, Alain, Mossafa, Hossein, Preudhomme, Claude, Ifrah, Norbert, Dombret, Hervé, Macintyre, Elizabeth, and Asnafi, Vahid

Subjects
*LYMPHOCYTIC leukemia, *BINDING sites, *LEUCOCYTOSIS, *CELL membranes, *DRUG therapy
Abstract

The SET-NUP214 (TAF1/CAN) fusion gene is a rare genetic event in T-cell acute lymphoblastic leukemia (T-ALL). Eleven (6%) of 196 T-ALL patients enrolled in the French Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) 2003 and 2005 trials harbored a SET-NUP214 transcript. SET-NUP214-positive patients were predominantly (10 [91%] of 11) T-cell receptor (TCR)-negative and strikingly associated with TCRγδ lineage T-ALLs, as defined by expression of TCRγδ, TCRδ and/or TCRγ rearrangements but no complete TCRβ variable diversity joining rearrangement in surface CD3/TCR-negative cases. When compared with SET-NUP214-negative patients, SET-NUP214-positive patients showed a significantly higher rate of corticosteroid resistance (91% vs 44%; P = .003) and chemotherapy resistance (100% vs 44%; P= .0001). All SET-NUP214-positive patients but one achieved complete remission, and 9 were allografted. Despite the poor early-treatment sensitivity, the outcome of SET-NUP214-positive patients was similar to that of SET-NUP214-negative patients. [ABSTRACT FROM AUTHOR]

Published
2014
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23. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Author

Bond, Jonathan, Krzywon, Aleksandra, Lhermitte, Ludovic, Roumier, Christophe, Roggy, Anne, Belhocine, Mohamed, Kheirallah, Alexander Abdulkader, Villarese, Patrick, Hypolite, Guillaume, Garnache-Ottou, Francine, Castaigne, Sylvie, Boissel, Nicolas, Asnafi, Vahid, Preudhomme, Claude, Dombret, Hervé, Laurenti, Elisa, and Macintyre, Elizabeth

Subjects
Survival Rate, Leukemia, Myeloid, Acute, hemic and lymphatic diseases, Biomarkers, Tumor, Computational Biology, Humans, Cell Differentiation, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Transcriptome, 3. Good health, Leukemia, Biphenotypic, Acute
Abstract

Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors. This framework can provide diagnostic challenges for immunophenotypically heterogeneous immature leukemias, and ignores recent advances in understanding of developmental multipotency of diverse normal hematopoietic progenitor populations that are identified by transcriptional signatures. We performed transcriptional analyses of a large series of acute myeloid and lymphoid leukemias and detected significant overlap in gene expression between cases in different diagnostic categories. Bioinformatic classification of leukemias along a continuum of hematopoietic differentiation identified leukemias at the myeloid/T-lymphoid interface, which shared gene expression programs with a series of multi or oligopotent hematopoietic progenitor populations, including the most immature CD34+CD1a-CD7- subset of early thymic precursors. Within these interface acute leukemias (IALs), transcriptional resemblance to early lymphoid progenitor populations and biphenotypic leukemias was more evident in cases originally diagnosed as AML, rather than T-ALL. Further prognostic analyses revealed that expression of IAL transcriptional programs significantly correlated with poor outcome in independent AML patient cohorts. Our results suggest that traditional binary approaches to acute leukemia categorization are reductive, and that identification of IALs could allow better treatment allocation and evaluation of therapeutic options.

24. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Author

Bond, Jonathan, Krzywon, Aleksandra, Lhermitte, Ludovic, Roumier, Christophe, Roggy, Anne, Belhocine, Mohamed, Kheirallah, Alexander Abdulkader, Villarese, Patrick, Hypolite, Guillaume, Garnache-Ottou, Francine, Castaigne, Sylvie, Boissel, Nicolas, Asnafi, Vahid, Preudhomme, Claude, Dombret, Hervé, Laurenti, Elisa, and Macintyre, Elizabeth

Subjects
45, hemic and lymphatic diseases, 631/67/1990/283/1897, 38/23, article, 631/67/1990/283/2125, 38/61, 3. Good health, 38
Abstract

Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors. This framework can provide diagnostic challenges for immunophenotypically heterogeneous immature leukemias, and ignores recent advances in understanding of developmental multipotency of diverse normal hematopoietic progenitor populations that are identified by transcriptional signatures. We performed transcriptional analyses of a large series of acute myeloid and lymphoid leukemias and detected significant overlap in gene expression between cases in different diagnostic categories. Bioinformatic classification of leukemias along a continuum of hematopoietic differentiation identified leukemias at the myeloid/T-lymphoid interface, which shared gene expression programs with a series of multi or oligopotent hematopoietic progenitor populations, including the most immature CD34+CD1a−CD7− subset of early thymic precursors. Within these interface acute leukemias (IALs), transcriptional resemblance to early lymphoid progenitor populations and biphenotypic leukemias was more evident in cases originally diagnosed as AML, rather than T-ALL. Further prognostic analyses revealed that expression of IAL transcriptional programs significantly correlated with poor outcome in independent AML patient cohorts. Our results suggest that traditional binary approaches to acute leukemia categorization are reductive, and that identification of IALs could allow better treatment allocation and evaluation of therapeutic options.

25. In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent.

Author

Angelot-Delettre F, Roggy A, Frankel AE, Lamarthee B, Seilles E, Biichle S, Royer B, Deconinck E, Rowinsky EK, Brooks C, Bardet V, Benet B, Bennani H, Benseddik Z, Debliquis A, Lusina D, Roussel M, Solly F, Ticchioni M, Saas P, and Garnache-Ottou F

Subjects
Adult, Aged, Aged, 80 and over, Animals, Apoptosis, Biomarkers, Tumor genetics, Blotting, Western, Cell Proliferation, Dendritic Cells metabolism, Female, Flow Cytometry, Hematologic Neoplasms metabolism, Hematologic Neoplasms therapy, Humans, In Vitro Techniques, Interleukin-3 Receptor alpha Subunit genetics, Interleukin-3 Receptor alpha Subunit metabolism, Male, Mice, Mice, Inbred NOD, Mice, SCID, Middle Aged, Myeloproliferative Disorders metabolism, Myeloproliferative Disorders therapy, Plasmacytoma metabolism, Plasmacytoma therapy, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Biomarkers, Tumor metabolism, Dendritic Cells pathology, Hematologic Neoplasms pathology, Interleukin-3 Receptor alpha Subunit antagonists & inhibitors, Myeloproliferative Disorders pathology, Plasmacytoma pathology, Recombinant Fusion Proteins therapeutic use
Abstract

Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from plasmacytoid dendritic cells. There is currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively evaluated. Since blastic plasmacytoid dendritic cell neoplasm cells express high levels of interleukin-3 receptor α chain (IL3-Rα or CD123), antitumor effects of the interleukin-3 receptor-targeted drug SL-401 against blastic plasmacytoid dendritic cell neoplasm were evaluated in vitro and in vivo. The cytotoxicity of SL-401 was assessed in patient-derived blastic plasmacytoid dendritic cell neoplasm cell lines (CAL-1 and GEN2.2) and in primary blastic plasmacytoid dendritic cell neoplasm cells isolated from 12 patients using flow cytometry and an in vitro cytotoxicity assay. The cytotoxic effects of SL-401 were compared to those of several relevant cytotoxic agents. SL-401 exhibited a robust cytotoxicity against blastic plasmacytoid dendritic cell neoplasm cells in a dose-dependent manner. Additionally, the cytotoxic effects of SL-401 were observed at substantially lower concentrations than those achieved in clinical trials to date. Survival of mice inoculated with a blastic plasmacytoid dendritic cell neoplasm cell line and treated with a single cycle of SL-401 was significantly longer than that of untreated controls (median survival, 58 versus 17 days, P<0.001). These findings indicate that blastic plasmacytoid dendritic cell neoplasm cells are highly sensitive to SL-401, and support further evaluation of SL-401 in patients suffering from blastic plasmacytoid dendritic cell neoplasm., (Copyright© Ferrata Storti Foundation.)

Published
2015
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