15,201 results on '"Roesch A"'
Search Results
2. Context-Aware Full Body Anonymization using Text-to-Image Diffusion Models
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Zwick, Pascal, Roesch, Kevin, Klemp, Marvin, and Bringmann, Oliver
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,I.4.0 ,I.2.0 - Abstract
Anonymization plays a key role in protecting sensible information of individuals in real world datasets. Self-driving cars for example need high resolution facial features to track people and their viewing direction to predict future behaviour and react accordingly. In order to protect people's privacy whilst keeping important features in the dataset, it is important to replace the full body of a person with a highly detailed anonymized one. In contrast to doing face anonymization, full body replacement decreases the ability of recognizing people by their hairstyle or clothes. In this paper, we propose a workflow for full body person anonymization utilizing Stable Diffusion as a generative backend. Text-to-image diffusion models, like Stable Diffusion, OpenAI's DALL-E or Midjourney, have become very popular in recent time, being able to create photorealistic images from a single text prompt. We show that our method outperforms state-of-the art anonymization pipelines with respect to image quality, resolution, Inception Score (IS) and Frechet Inception Distance (FID). Additionally, our method is invariant with respect to the image generator and thus able to be used with the latest models available.
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- 2024
3. Laser-FLASH: radiobiology at high dose, ultra-high dose-rate, single pulse laser-driven proton source
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Flacco, A., Bayart, E., Giaccaglia, C., Monzac, J., Romagnani, L., Cavallone, M., Patriarca, A., DeMarzi, L., Fouillade, C., Heinrich, S., Lamarre-Jouenne, I., Parodi, K., Rösch, T., Schreiber, J., and Tischendorf, L.
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Physics - Medical Physics ,Physics - Applied Physics ,Physics - Plasma Physics - Abstract
Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose rates, short duration and broad energy spectrum. Typical temporal modality of laser-driven irradiation, the so-called fast-fractionation, results from the composition of multiple, temporally separated, ultra-short dose fractions. In this paper we present the use of a high-energy laser system for delivering the target dose in a single nanosecond pulse, for ultra-fast irradiation of biological samples. A transport line composed by two permanent magnet quadrupoles and a scattering system is used to improve the dose profile and to control the delivered dose-per-pulse. A single-shot dosimetry protocol for the broad-spectrum proton source using Monte Carlo simulations was developed. Doses as high as 20Gy could be delivered in a single shot, lasting less than 10ns over a 1.0cm diameter sample holder, at a dose-rate exceeding 10^9 Gy/s. Exploratory application of extreme laser-driven irradiation conditions, falling within the FLASH irradiation protocol, are presented for in vitro and in vivo irradiation. A reduction of radiation-induced oxidative stress in-vitro and radiation-induced developmental damage in vivo were observed, whereas anti-tumoral efficacy was confirmed by cell survival assay., Comment: 13 pages, 15 figures
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- 2024
4. Validating a Pragmatic Measure of Evidence-Based Practice (EBP) Delivery: Therapist Reports of EBP Strategy Delivery and Associations with Child Outcome Trajectories
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Anna S. Lau, Teresa Lind, Julia Cox, Mojdeh Motamedi, Joyce H. L. Lui, Colby Chlebowski, Ashley Flores, Devynne Diaz, Scott Roesch, and Lauren Brookman-Frazee
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Pragmatic measures of evidence-based practice (EBP) implementation can support and evaluate implementation efforts. We examined the predictive validity of therapist reports of EBP strategy delivery for children's mental health outcomes. Data were obtained from 1,380 sessions with 248 children delivered by 76 therapists in two county systems. Children (M[subscript age]=11.8 years, SD = 3.7) presented with internalizing (52%), externalizing (27%), trauma (16%), and other (5%) concerns. Therapists reported their delivery of EBP strategies on a revised version of the EBP Concordant Care Assessment (ECCA; Brookman-Frazee, et al., "Administration and Policy in Mental Health and Mental Health Services Research," 48, 155-170, 2021) that included 25 content (e.g., parenting, cognitive behavioral) and 12 technique strategies (e.g., modeling, practice/role-play). On average, 5.6 ECCA session reports (SD = 2.3) were obtained for each client, and caregivers reported symptoms on the Brief Problem Checklist (Chorpita, et al., "Journal of Consulting and Clinical Psychology," 78(4), 526-536, 2010) at baseline, weekly over two months, and again at four months. Multilevel models examined whether the mean extensiveness of each EBP strategy predicted trajectories of child outcomes. More individual technique (6 of 12) than content strategies (1 of 25) were associated with outcome trajectories. For techniques, more extensive use of Performance Feedback and Live Coaching and less extensive use of Addressing Barriers were associated with greater declines in total symptoms, and more extensive use of Establishing/Reviewing Goals, Tracking/Reviewing Progress, and Assigning/Reviewing Homework was associated with declines in externalizing symptoms. For content, more extensive use of Cognitive Restructuring was associated with declines in total symptoms. In addition, higher average extensiveness ratings of the top content strategy across sessions was associated with greater declines in total and externalizing symptoms. Therapist-reported delivery of some EBP strategies showed evidence of predictive validity and may hold utility in indexing quality of care.
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- 2024
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5. A pragmatic randomized trial of mailed fecal immunochemical testing to increase colorectal cancer screening among low‐income and minoritized populations
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Martínez, María Elena, Roesch, Scott, Largaespada, Valesca, Castañeda, Sheila F, Nodora, Jesse N, Rabin, Borsika A, Covin, Jennifer, Ortwine, Kristine, Preciado‐Hidalgo, Yesenia, Howard, Nicole, Schultz, James, Stamm, Nannette, Ramirez, Daniel, Halpern, Michael T, and Gupta, Samir
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Biomedical and Clinical Sciences ,Health Services and Systems ,Public Health ,Health Sciences ,Clinical Sciences ,Emerging Infectious Diseases ,Colo-Rectal Cancer ,Social Determinants of Health ,Minority Health ,Cancer ,Aging ,Health Disparities ,Comparative Effectiveness Research ,Clinical Trials and Supportive Activities ,Infectious Diseases ,Clinical Research ,Prevention ,Women's Health ,Digestive Diseases ,Health Services ,4.4 Population screening ,Good Health and Well Being ,Aged ,Female ,Humans ,Male ,Middle Aged ,Colorectal Neoplasms ,COVID-19 ,Early Detection of Cancer ,Feces ,Hispanic or Latino ,Occult Blood ,Poverty ,Health Services Accessibility ,Healthcare Disparities ,colorectal cancer screening ,community health centers ,disparities ,fecal immunochemical test ,minoritized populations ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
BackgroundColorectal cancer (CRC) screening is underused, particularly among low-income and minoritized populations, for whom the coronavirus disease 2019 (COVID-19) pandemic has challenged progress in achieving equity.MethodsA hub-and-spoke model was used. The hub was a nonacademic organization and the spokes were three community health center (CHC) systems overseeing numerous clinic sites. Via a cluster-randomized trial design, nine clinic sites were randomized to intervention and 16 clinic sites were randomized to usual care. Patient-level interventions included invitation letters, mailed fecal immunochemical tests (FITs), and call/text-based reminders. Year 1 intervention impact, which took place during the COVID-19 pandemic, was assessed as the proportion completing screening among individuals not up to date at baseline, which compared intervention and nonintervention clinics accounting for intraclinic cluster variation; confidence intervals (CIs) around differences not including 0 were interpreted as statistically significant.ResultsAmong 26,736 patients who met eligibility criteria, approximately 58% were female, 55% were Hispanic individuals, and 44% were Spanish speaking. The proportion completing screening was 11.5 percentage points (ppts) (95% CI, 6.1-16.9 ppts) higher in intervention versus usual care clinics. Variation in differences between intervention and usual care clinics was observed by sex (12.6 ppts [95% CI, 7.2-18.0 ppts] for females; 8.8 ppts [95% CI, 4.7-13.9 ppts] for males) and by racial and ethnic group (13.8 ppts [95% CI, 7.0-20.6 ppts] for Hispanic individuals; 13.0 ppts [95% CI, 3.6-22.4 ppts] for Asian individuals; 11.3 ppts [95% CI, 5.8-16.8 ppts] for non-Hispanic White individuals; 6.1 ppts [95% CI, 0.8-10.4 ppts] for Black individuals).ConclusionsA regional mailed FIT intervention was effective for increasing CRC screening rates across CHC systems serving diverse, low-income populations.
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- 2024
6. BlessemFlood21: Advancing Flood Analysis with a High-Resolution Georeferenced Dataset for Humanitarian Aid Support
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Polushko, Vladyslav, Jenal, Alexander, Bongartz, Jens, Weber, Immanuel, Hatic, Damjan, Rösch, Ronald, März, Thomas, Rauhut, Markus, and Weinmann, Andreas
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Floods are an increasingly common global threat, causing emergencies and severe damage to infrastructure. During crises, organisations such as the World Food Programme use remotely sensed imagery, typically obtained through drones, for rapid situational analysis to plan life-saving actions. Computer Vision tools are needed to support task force experts on-site in the evaluation of the imagery to improve their efficiency and to allocate resources strategically. We introduce the BlessemFlood21 dataset to stimulate research on efficient flood detection tools. The imagery was acquired during the 2021 Erftstadt-Blessem flooding event and consists of high-resolution and georeferenced RGB-NIR images. In the resulting RGB dataset, the images are supplemented with detailed water masks, obtained via a semi-supervised human-in-the-loop technique, where in particular the NIR information is leveraged to classify pixels as either water or non-water. We evaluate our dataset by training and testing established Deep Learning models for semantic segmentation. With BlessemFlood21 we provide labeled high-resolution RGB data and a baseline for further development of algorithmic solutions tailored to flood detection in RGB imagery.
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- 2024
7. A gamma-ray flare from TXS 1508+572: characterizing the jet of a $z=4.31$ blazar in the early Universe
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Gokus, Andrea, Böttcher, Markus, Errando, Manel, Kreter, Michael, Heßdörfer, Jonas, Eppel, Florian, Kadler, Matthias, Smith, Paul S., Benke, Petra, Gurvits, Leonid I., Kraus, Alex, Lisakov, Mikhail, McBride, Felicia, Ros, Eduardo, Rösch, Florian, and Wilms, Jörn
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Blazars can be detected from very large distances due to their high luminosity. However, the detection of $\gamma$-ray emission of blazars beyond $z=3$ has only been confirmed for a small number of sources. Such observations probe the growth of supermassive black holes close to the peak of star formation in the history of galaxy evolution. As a result from a continuous monitoring of a sample of 80 $z>3$ blazars with Fermi-LAT, we present the first detection of a $\gamma$-ray flare from the $z=4.31$ blazar TXS 1508+572. This source showed high $\gamma$-ray activity from February to August 2022, reaching a peak luminosity comparable to the most luminous flares ever detected with Fermi -LAT. We conducted a multiwavelength observing campaign involving XMM-Newton, Swift, the Effelsberg 100-m radio telescope and the Very Long Baseline Array. In addition, we make use of the monitoring programs by the Zwicky Transient Facility and NEOWISE at optical and infrared wavelengths, respectively. We find that the source is particularly variable in the infrared band on daily time scales. The spectral energy distribution collected during our campaign is well described by a one-zone leptonic model, with the $\gamma$-ray flare originating from an increase of external Compton emission as a result of a fresh injection of accelerated electrons., Comment: 19 pages, 8 figures; accepted by ApJ on July 30 - Initial version on arXiv is the submitted one
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- 2024
8. Very-long-baseline interferometry study of the flaring blazar TXS 1508+572 in the early Universe
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Benke, P., Gokus, A., Lisakov, M., Gurvits, L. I., Eppel, F., Heßdörfer, J., Kadler, M., Kovalev, Y. Y., Ros, E., and Rösch, F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
High-redshift blazars provide valuable input to studies of the evolution of active galactic nuclei (AGN) jets and provide constraints on cosmological models. Detections at high energies ($0.1<\mathrm{E}<100$ GeV) of these distant sources are rare, but when they exhibit bright gamma-ray flares, we are able to study them. However, contemporaneous multi-wavelength observations of high-redshift objects ($z>4$) during their different periods of activity have not been carried out so far. An excellent opportunity for such a study arose when the blazar TXS 1508+572 ($z=4.31$) exhibited a $\gamma$-ray flare in 2022 February in the $0.1-300$ GeV range with a flux 25 times brighter than the one reported in the in the fourth catalog of the \textit{Fermi} Large Area Telescope. Our goal is to monitor the morphological changes, spectral index and opacity variations that could be associated with the preceding $\gamma$-ray flare in TXS 1508+572 to find the origin of the high-energy emission in this source. We also plan to compare the source characteristics in the radio band to the blazars in the local Universe ($z<0.1$). In addition, we aim to collect quasi-simultaneous data to our multi-wavelength observations of the object, making TXS 1508+572 the first blazar in the early Universe ($z>4$) with contemporaneous multi-frequency data available in its high state. In order to study the parsec-scale structure of the source, we performed three epochs of very-long-baseline interferometry (VLBI) follow-up observations with the Very Long Baseline Array (VLBA) supplemented with the Effelsberg 100-m Telescope at 15, 22, and 43 GHz, which corresponds to 80, 117, and 228 GHz in the rest frame of TXS 1508+572. In addition, one 86 GHz (456 GHz) measurement was performed by the VLBA and the Green Bank Telescope during the first epoch.
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- 2024
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9. First VLBI detection of Fornax A
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Paraschos, G. F., Wielgus, M., Benke, P., Mpisketzis, V., Rösch, F., Dasyra, K., Ros, E., Kadler, M., Ojha, R., Edwards, P. G., Hyland, L., Quick, J. F. H., and Weston, S.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Radio galaxies harbouring jetted active galactic nuclei are a frequent target of very-long-baseline interferometry (VLBI) because they play an essential role in exploring how jets form and propagate. Hence, only few have not been detected with VLBI yet; Fornax A is one of the most famous examples. Here we present the first detection of the compact core region of Fornax A with VLBI. At 8.4 GHz the faint core is consistent with an unresolved point source. We constrained its flux density to be $S_0 = 47.5-62.3\,\textrm{mJy}$ and its diameter to be $D^\textrm{min}_0 \leq 70\,\mu\textrm{as}$. The high values of the measured brightness temperature ($T_\textrm{B} \gtrsim 10^{11}\,\textrm{K}$) imply that the observed radiation is of non-thermal origin, likely associated with the synchrotron emission from the active galactic nucleus. We also investigated the possibility of a second radio source being present within the field of view. Adding a second Gaussian component to the geometrical model-fit does not significantly improve the quality of the fit and we, therefore, conclude that our detection corresponds to the compact core of Fornax A. Analysis of the non-trivial closure phases provides evidence for the detection of more extended flux density, on the angular scale of $\sim4000\,\mu\textrm{as}$. Finally, the fractional circular polarisation of the core is consistent with zero, with a conservative upper limit being $m_\textrm{circ} \leq 4\%$., Comment: 4 pages, 2 figures, accepted for publication in A&A
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- 2024
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10. Psychometric Properties of the Weight Loss Readiness Test in Active Duty Military Personnel Enrolled in a Weight Management Trial
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Tynan, Mara, Afari, Niloofar, Roesch, Scott, and Herbert, Matthew S
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Behavioral and Social Science ,Clinical Research ,Nutrition ,Obesity ,Humans ,Military Personnel ,Psychometrics ,Male ,Adult ,Female ,Reproducibility of Results ,Surveys and Questionnaires ,Weight Loss ,Motivation ,Weight Reduction Programs ,Body Mass Index ,Factor Analysis ,Statistical ,Human Movement and Sports Sciences ,Public Health and Health Services ,Strategic ,Defence & Security Studies ,Clinical sciences ,Health services and systems - Abstract
IntroductionThe Weight Loss Readiness Test (WLRT) was developed to encourage consideration of factors influencing readiness to engage in weight loss. The WLRT is used clinically, most notably to assess motivation before initiating Navy weight management programs, yet little is known about its psychometric properties.Materials and methodsThis study examined the reliability, convergent and predictive validity, and factor structure of the WLRT in a sample of active duty service members enrolling in a Navy-based weight management program (N = 178, identified as female = 61%, mean age = 29.7 years, mean baseline body mass index = 33.1 kg/m2). All procedures were approved by the respective Institutional Review Boards and research committees.ResultsExploratory factor analysis revealed a 5-factor structure explaining 52% of the variance that best fit the data with low to moderate correlations between factors: (1) Motivation, (2) Exercise-Related Confidence, (3) Non-Exercise Confidence, (4) Cues, and (5) Anticipated Satisfaction. Internal reliability of subscales was acceptable to good (α = 0.755-0.903). Generally, convergent validity was found between the identified subscales and other measures of motivation, confidence, and disinhibited eating in expected directions. No relationships were found between the subscales and predictive validity outcomes (weight change, program attendance).ConclusionsResults indicate adequate structural and convergent validity in the WLRT, but that weight loss readiness, as measured by the WLRT, does not provide predictive validity regarding weight loss or attendance outcomes in this sample. Nonetheless, this measure offers clinical utility in fostering thoughtful conversations about weight loss. The WLRT uniquely focuses on long-term maintenance of behavior change and differentiates between exercise-related and non-exercise confidence. Future studies should further probe the utility of this measure in other populations and the contexts in which it is being used.
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- 2024
11. Non-coercive Neumann boundary control problems
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Apel, Thomas, Mateos, Mariano, and Rösch, Arnd
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Mathematics - Optimization and Control ,49M41, 35B65, 65N30 - Abstract
The article examines a linear-quadratic Neumann control problem that is governed by a non-coercive elliptic equation. Due to the non-self-adjoint nature of the linear control-to-state operator, it is necessary to independently study both the state and adjoint state equations. The article establishes the existence and uniqueness of solutions for both equations, with minimal assumptions made about the problem's data. Next, the regularity of these solutions is studied in three frameworks: Hilbert-Sobolev spaces, Sobolev-Slobodecki\u\i{} spaces, and weighted Sobolev spaces. These regularity results enable a numerical analysis of the finite element approximation of both the state and adjoint state equations. The results cover both convex and non-convex domains and quasi-uniform and graded meshes. Finally, the optimal control problem is analyzed and discretized. Existence and uniqueness of the solution, first-order optimality conditions, and error estimates for the finite element approximation of the control are obtained. Numerical experiments confirming these results are included. A significant highlight is that the discretization error estimates known from the literature, are improved even for the coercive case.
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- 2024
12. PITA: Physics-Informed Trajectory Autoencoder
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Fischer, Johannes, Rösch, Kevin, Lauer, Martin, and Stiller, Christoph
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Computer Science - Machine Learning ,Computer Science - Robotics - Abstract
Validating robotic systems in safety-critical appli-cations requires testing in many scenarios including rare edgecases that are unlikely to occur, requiring to complement real-world testing with testing in simulation. Generative models canbe used to augment real-world datasets with generated data toproduce edge case scenarios by sampling in a learned latentspace. Autoencoders can learn said latent representation for aspecific domain by learning to reconstruct the input data froma lower-dimensional intermediate representation. However, theresulting trajectories are not necessarily physically plausible, butinstead typically contain noise that is not present in the inputtrajectory. To resolve this issue, we propose the novel Physics-Informed Trajectory Autoencoder (PITA) architecture, whichincorporates a physical dynamics model into the loss functionof the autoencoder. This results in smooth trajectories that notonly reconstruct the input trajectory but also adhere to thephysical model. We evaluate PITA on a real-world dataset ofvehicle trajectories and compare its performance to a normalautoencoder and a state-of-the-art action-space autoencoder.
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- 2024
13. Enhancing Conceptual Understanding in Multimodal Contrastive Learning through Hard Negative Samples
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Rösch, Philipp J., Oswald, Norbert, Geierhos, Michaela, and Libovický, Jindřich
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Computation and Language ,Computer Science - Information Retrieval ,I.4 ,I.7 - Abstract
Current multimodal models leveraging contrastive learning often face limitations in developing fine-grained conceptual understanding. This is due to random negative samples during pretraining, causing almost exclusively very dissimilar concepts to be compared in the loss function. Consequently, the models struggle with fine-grained semantic differences. To address this problem, we introduce a novel pretraining method incorporating synthetic hard negative text examples. The hard negatives permute terms corresponding to visual concepts, leading to a more fine-grained visual and textual concept alignment. Further, we introduce InpaintCOCO, a new challenging dataset for assessing the fine-grained alignment of colors, objects, and sizes in vision-language models. We created the dataset using generative inpainting from COCO images by changing the visual concepts so that the images no longer match their original captions. Our results show significant improvements in fine-grained concept understanding across a wide range of vision-language datasets, including our InpaintCOCO dataset.
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- 2024
14. Validating a Pragmatic Measure of Evidence-Based Practice (EBP) Delivery: Therapist Reports of EBP Strategy Delivery and Associations with Child Outcome Trajectories
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Lau, Anna S., Lind, Teresa, Cox, Julia, Motamedi, Mojdeh, Lui, Joyce H. L., Chlebowski, Colby, Flores, Ashley, Diaz, Devynne, Roesch, Scott, and Brookman-Frazee, Lauren
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- 2024
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15. Continuous Blood Pressure Indices During the First 72 Hours and Functional Outcome in Patients with Spontaneous Intracerebral Hemorrhage
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Mengel, Annerose, Siokas, Vasileios, Buesink, Rebecca, Roesch, Sara, Laichinger, Kornelia, Ferizi, Redina, Dardiotis, Efthimios, Sartor-Pfeiffer, Jennifer, Single, Constanze, Hauser, Till-Karsten, Krumbholz, Markus, Ziemann, Ulf, and Feil, Katharina
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- 2024
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16. Real-World Outcomes with the KEYNOTE-522 Regimen in Early-Stage Triple-Negative Breast Cancer
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Connors, Casey, Valente, Stephanie A., ElSherif, Ayat, Escobar, Paula, Chichura, Anna, Kopicky, Lauren, Roesch, Erin, Ritner, Julie, McIntire, Patrick, Wu, Yueqi, Tu, Chao, and Lang, Julie E.
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- 2024
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17. Diagnosis of periprosthetic loosening of total hip and knee arthroplasty using 68Gallium-Zoledronate PET/CT
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Touet, A., Koob, S., Kürpig, S., Roos, J., Roesch, F., Wirtz, DC., Essler, M., and Gaertner, FC.
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- 2024
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18. Neighborhood environments and psychological distress 6-years later: results from the San Diego HCHS/SOL community and surrounding areas study
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Gallo, Linda C., Roesch, Scott C., Rosas, Carlos E., Mendez-Rodriguez, Heidy, Talavera, Gregory A., Allison, Matthew A., Sotres-Alvarez, Daniela, Sallis, James F., Jankowska, Marta M., Savin, Kimberly L., Perreira, Krista M., Chambers, Earle C., Daviglus, Martha L., and Carlson, Jordan A.
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- 2024
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19. New second order sufficient optimality conditions for state constrained parabolic control problems
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Casas, Eduardo, Mateos, Mariano, and Rösch, Arnd
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Mathematics - Optimization and Control ,35K58, 35R06, 49K20 - Abstract
We study a control problem governed by a semilinear parabolic equation with pointwise control and state constraints imposed at every point of the space-time cylinder. We obtain second order sufficient optimality conditions for local optimality in the sense of $L^2(Q)$. Our results are valid for spatial domains of dimension less than or equal to three.
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- 2024
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20. Connected McMullen-like Julia sets in a Chebyshev-Halley Family
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Canela, Jordi, Garijo, Antonio, and Roesch, Pascale
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Mathematics - Dynamical Systems ,37F10, 37F31, 37F44 - Abstract
In this paper we study a one parameter family of rational maps obtained by applying the Chebyshev-Halley root finding algorithms. We show that the dynamics near parameters where the family presents some degeneracy might be understood from the point of view of singular perturbations. More precisely, we relate the dynamics of those maps with the one of the McMullen family $M_{\lambda}(z)=z^4 + \lambda /z^2$, using quasi-conformal surgery.
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- 2024
21. TELAMON: Effelsberg monitoring of AGN jets with very-high-energy astroparticle emission -- I. Program description and sample characterization
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Eppel, F., Kadler, M., Heßdörfer, J., Benke, P., Debbrecht, L., Eich, J., Gokus, A., Hämmerich, S., Kirchner, D., Paraschos, G. F., Rösch, F., Schulga, W., Sinapius, J., Weber, P., Bach, U., Dorner, D., Edwards, P. G., Giroletti, M., Kraus, A., Hervet, O., Koyama, S., Krichbaum, T. P., Mannheim, K., Ros, E., Zacharias, M., and Zensus, J. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Aims. We introduce the TELAMON program which is using the Effelsberg 100-m telescope to monitor the radio spectra of active galactic nuclei (AGN) under scrutiny in astroparticle physics, specifically TeV blazars and candidate neutrino-associated AGN. Here, we present and characterize our main sample of TeV-detected blazars. Methods. We analyze the data sample from the first ~2.5 years of observations between August 2020 and February 2023 in the range from 14 GHz to 45 GHz. During this pilot phase, we have observed all 59 TeV-detected blazars in the Northern Hemisphere (i.e., Dec. >0{\deg}) known at the time of observation. We discuss the basic data reduction and calibration procedures used for all TELAMON data and introduce a sub-band averaging method used to calculate average light curves for the sources in our sample. Results. The TeV-selected sources in our sample exhibit a median flux density of 0.12 Jy at 20 mm, 0.20 Jy at 14 mm and 0.60 Jy at 7 mm. The spectrum for most of the sources is consistent with a flat radio spectrum and we find a median spectral index ($S(\nu)\propto\nu^\alpha$) of $\alpha=-0.11$. Our results on flux density and spectral index are consistent with previous studies of TeV-selected blazars. Compared to the GeV-selected F-GAMMA sample, TELAMON sources are significantly fainter in the radio band. This is consistent with the double-humped spectrum of blazars being shifted towards higher frequencies for TeV-emitters (in particular for high-synchrotron peaked BL Lac type objects), which results in a lower radio flux density. The spectral index distribution of our TeV-selected blazar sample is not significantly different from the GeV-selected F-GAMMA sample. Moreover, we present a strategy to track the light curve evolution of sources in our sample for future variability and correlation analysis., Comment: 16 pages, 11 figures, 4 tables, accepted for publication in A&A
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- 2024
22. A Report on Physician Wellness during the Transition from Community EM Physicians to Faculty in a New Residency Training Program
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Hoelle, Robyn, Mishkin, Hannah, Bentley, Thomas, DiFebo, John, and Roesch, Joseph
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- 2024
23. Targeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer
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Bao, Guangfa, Wang, Ziqiang, Liu, Luoxia, Zhang, Buchuan, Song, Shuang, Wang, Dongdong, Cheng, Siyuan, Moon, Eu-Song, Roesch, Frank, Zhao, Jun, Yu, Bo, and Zhu, Xiaohua
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- 2024
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24. Mutational spectrum in patients with dominant non-syndromic hearing loss in Austria
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Frohne, Alexandra, Vrabel, Sybille, Laccone, Franco, Neesen, Juergen, Roesch, Sebastian, Dossena, Silvia, Schoefer, Christian, Frei, Klemens, and Parzefall, Thomas
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- 2024
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25. Moderators of Loneliness Trajectories in People with Systemic Sclerosis During the COVID-19 Pandemic: A SPIN COVID-19 Cohort Longitudinal Study
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Rapoport, Chelsea S., Choi, Alyssa K., Kwakkenbos, Linda, Carrier, Marie-Eve, Henry, Richard S., Levis, Brooke, Bartlett, Susan J., Gietzen, Amy, Gottesman, Karen, Guillot, Geneviève, Lawrie-Jones, Amanda, Mayes, Maureen D., Mouthon, Luc, Richard, Michelle, Worron-Sauvé, Maureen, Benedetti, Andrea, Roesch, Scott C., Thombs, Brett D., and Malcarne, Vanessa L.
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- 2024
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26. Relax: Composable Abstractions for End-to-End Dynamic Machine Learning
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Lai, Ruihang, Shao, Junru, Feng, Siyuan, Lyubomirsky, Steven S., Hou, Bohan, Lin, Wuwei, Ye, Zihao, Jin, Hongyi, Jin, Yuchen, Liu, Jiawei, Jin, Lesheng, Cai, Yaxing, Jiang, Ziheng, Wu, Yong, Park, Sunghyun, Srivastava, Prakalp, Roesch, Jared G., Mowry, Todd C., and Chen, Tianqi
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Programming Languages - Abstract
Dynamic shape computations have become critical in modern machine learning workloads, especially in emerging large language models. The success of these models has driven demand for deploying them to a diverse set of backend environments. In this paper, we present Relax, a compiler abstraction for optimizing end-to-end dynamic machine learning workloads. Relax introduces first-class symbolic shape annotations to track dynamic shape computations globally across the program. It also introduces a cross-level abstraction that encapsulates computational graphs, loop-level tensor programs, and library calls in a single representation to enable cross-level optimizations. We build an end-to-end compilation framework using the proposed approach to optimize dynamic shape models. Experimental results on large language models show that Relax delivers performance competitive with state-of-the-art hand-optimized systems across platforms and enables deployment of emerging dynamic models to a broader set of environments, including mobile phones, embedded devices, and web browsers.
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- 2023
27. TANAMI: Tracking Active Galactic Nuclei with Austral Milliarcsecond Interferometry. III. First-epoch S band images
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Benke, Petra, Rösch, Florian, Ros, Eduardo, Kadler, Matthias, Ojha, Roopesh, Edwards, Philip G., Horiuchi, Shinji, Hyland, Lucas J., Phillips, Chris, Quick, Jonathan F. H., Stevens, Jamie, Tzioumis, Anastasios K., and Weston, Stuart
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
With the emergence of very high energy astronomy (VHE; E>100 GeV), new open questions were presented to astronomers studying the multi-wavelength emission from blazars. Answers to these open questions, such as the Doppler crisis, and finding the location of the high-energy activity have eluded us thus far. Recently, quasi-simultaneous multi-wavelength monitoring programs have shown considerable success in investigating blazar activity. After the launch of the Fermi Gamma-ray Space Telescope in 2008, such quasi-simultaneous observations across the electromagnetic spectrum became possible. In addition, with very long baseline interferometry (VLBI) observations we can resolve the central parsec region of active galactic nuclei (AGN) and compare morphological changes to the gamma-ray activity to study high-energy emitting blazars. To achieve our goals, we need sensitive, long-term VLBI monitoring of a complete sample of VHE detected AGN. We performed VLBI observations of TeV-detected AGN and high likelihood neutrino associations as of December of 2021 with the Long Baseline Array (LBA) and other southern hemisphere radio telescopes at 2.3 GHz. In this paper we present first light TANAMI S-band images, focusing on the TeV-detected sub-sample of the full TANAMI sample. Apart from these very high energy-detected sources, we also show images of the two flux density calibrators and two additional sources included in the observations. We study the redshift, 0.1-100 GeV photon flux and S-band core brightness temperature distributions of the TeV-detected objects, and find that flat spectrum radio quasars and low synchrotron peaked sources on average show higher brightness temperatures than high-synchrotron-peaked BL Lacs. Sources with bright GeV gamma-ray emission also show higher brightness temperature values than gamma-low sources.
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- 2023
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28. The Impact of Southern-Hemisphere Radio Blazar Observations on Neutrino Astronomy
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Rösch, F., Benke, P., Kadler, M., Ros, E., Ojha, R., Edwards, P. G., Eppel, F., Heßdörfer, J., and Stevens, J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The origin of high-energy cosmic neutrinos detected by the IceCube observatory is a hotly debated topic in astroparticle physics. There is growing evidence that some of these neutrinos can be associated with active galactic nuclei (AGN) and especially with blazars. Several recent studies have revealed a statistical correlation between radio-bright AGN samples and IceCube neutrino event catalogs. In addition, a growing number of individual high-energy neutrinos have been found to coincide with individual radio-flaring blazars. These observational results strongly call for high-quality, high angular-resolution radio observations of such neutrino-associated blazars to study their parsec-scale jet structures. TANAMI is the only large and long-term VLBI monitoring program focused on the Southern sky. Within TANAMI, we put an emphasis on Southern IceCube neutrino candidate blazars at 2.3 GHz and 8.4 GHz. Here we present first results of the first high-quality, high angular-resolution VLBI observations of nine Southern-Hemisphere blazars that were associated to IceCube neutrino hotspots in the Southern sky. In the near future, the rapidly growing KM3NeT will complement IceCube by being sensitive to high-energy neutrinos mainly from the Southern Hemisphere. This will increase the importance of Southern-Hemisphere radio monitoring programs of neutrino-associated blazars, like TANAMI., Comment: 8 pages, 2 figures, 1 table, Proceedings of the 38th International Cosmic Ray Conference (ICRC2023)
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- 2023
29. TELAMON: Effelsberg Monitoring of AGN Jets with Very-High-Energy Astroparticle Emissions -- Polarization properties
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Heßdörfer, J., Kadler, M., Benke, P., Debbrecht, L., Eich, J., Eppel, F., Gokus, A., Hämmerich, S., Kirchner, D., Paraschos, G. F., Rösch, F., Schulga, W., Sinapius, J., Weber, P., Bach, U., Berge, D., Buson, S., Dorner, D., Edwards, P. G., Fromm, C. M., Giroletti, M., Hervet, O., Kappes, A., Koyama, S., Kraus, A., Krichbaum, T. P., Lindfors, E., Mannheim, K., Ojha, R., Pueschel, E., Ros, E., Schleicher, B., Sitarek, J., Wilms, J., Zacharias, M., and Zensus, J. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present recent results of the TELAMON program, which is using the Effelsberg 100-m telescope to monitor the radio spectra of active galactic nuclei (AGN) under scrutiny in astroparticle physics, namely TeV blazars and neutrino-associated AGN. Our sample includes all known Northern TeV-emitting blazars as well as blazars positionally coincident with IceCube neutrino alerts. Polarization can give additional insight into the source properties, as the polarized emission is often found to vary on different timescales and amplitudes than the total intensity emission. Here, we present an overview of the polarization properties of the TeV-emitting TELAMON sources at four frequencies in the 20 mm and 7 mm bands. While at 7 mm roughly $82\,\%$ of all observed sources are found to be significantly polarized, for 20 mm the percentage is $\sim58\,\%$. We find that most of the sources exhibit mean fractional polarizations of $<5\%$, matching the expectations of rather low polarization levels in these sources from previous studies at lower radio frequencies. Nevertheless, we demonstrate examples of how the polarized emission can provide additional information over the total intensity., Comment: 9 pages, 2 figures, Proceedings of the 38th International Cosmic Ray Conference (ICRC2023)
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- 2023
30. dacl1k: Real-World Bridge Damage Dataset Putting Open-Source Data to the Test
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Flotzinger, Johannes, Rösch, Philipp J., Oswald, Norbert, and Braml, Thomas
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Recognising reinforced concrete defects (RCDs) is a crucial element for determining the structural integrity, traffic safety and durability of bridges. However, most of the existing datasets in the RCD domain are derived from a small number of bridges acquired in specific camera poses, lighting conditions and with fixed hardware. These limitations question the usability of models trained on such open-source data in real-world scenarios. We address this problem by testing such models on our "dacl1k" dataset, a highly diverse RCD dataset for multi-label classification based on building inspections including 1,474 images. Thereby, we trained the models on different combinations of open-source data (meta datasets) which were subsequently evaluated both extrinsically and intrinsically. During extrinsic evaluation, we report metrics on dacl1k and the meta datasets. The performance analysis on dacl1k shows practical usability of the meta data, where the best model shows an Exact Match Ratio of 32%. Additionally, we conduct an intrinsic evaluation by clustering the bottleneck features of the best model derived from the extrinsic evaluation in order to find out, if the model has learned distinguishing datasets or the classes (RCDs) which is the aspired goal. The dacl1k dataset and our trained models will be made publicly available, enabling researchers and practitioners to put their models to the real-world test.
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- 2023
31. dacl10k: Benchmark for Semantic Bridge Damage Segmentation
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Flotzinger, Johannes, Rösch, Philipp J., and Braml, Thomas
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Reliably identifying reinforced concrete defects (RCDs)plays a crucial role in assessing the structural integrity, traffic safety, and long-term durability of concrete bridges, which represent the most common bridge type worldwide. Nevertheless, available datasets for the recognition of RCDs are small in terms of size and class variety, which questions their usability in real-world scenarios and their role as a benchmark. Our contribution to this problem is "dacl10k", an exceptionally diverse RCD dataset for multi-label semantic segmentation comprising 9,920 images deriving from real-world bridge inspections. dacl10k distinguishes 12 damage classes as well as 6 bridge components that play a key role in the building assessment and recommending actions, such as restoration works, traffic load limitations or bridge closures. In addition, we examine baseline models for dacl10k which are subsequently evaluated. The best model achieves a mean intersection-over-union of 0.42 on the test set. dacl10k, along with our baselines, will be openly accessible to researchers and practitioners, representing the currently biggest dataset regarding number of images and class diversity for semantic segmentation in the bridge inspection domain., Comment: 23 pages, 6 figures
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- 2023
32. Social and built neighborhood environments and sleep health: The Hispanic Community Health Study/Study of Latinos Community and Surrounding Areas and Sueño Ancillary Studies.
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Savin, Kimberly, Carlson, Jordan, Patel, Sanjay, Jankowska, Marta, Allison, Matthew, Sotres-Alvarez, Daniela, Sallis, James, Talavera, Gregory, Roesch, Scott, Malcarne, Vanessa, Larsen, Britta, Rutledge, Thomas, and Gallo, Linda
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residential segregation ,sleep initiation and maintenance disorders ,social determinants of health ,socioeconomic factors ,traffic-related pollution ,walking ,Humans ,Hispanic or Latino ,Neighborhood Characteristics ,Residence Characteristics ,Self Report ,Sleep ,Sleep Initiation and Maintenance Disorders ,Social Determinants of Health - Abstract
STUDY OBJECTIVES: To test associations between neighborhood social, built, and ambient environment characteristics and multidimensional sleep health in Hispanic/Latino adults. METHODS: Data were from San Diego-based Hispanic/Latino adults mostly of Mexican heritage enrolled in the Hispanic Community Health Study/Study of Latinos (N = 342). Home addresses were geocoded to ascertain neighborhood characteristics of greenness, walkability (density of intersections, retail spaces, and residences), socioeconomic deprivation (e.g. lower income, lower education), social disorder (e.g. vacant buildings, crime), traffic density, and air pollution (PM 2.5) in the Study of Latinos Communities and Surrounding Areas Study. Sleep dimensions of regularity, satisfaction, alertness, timing, efficiency, and duration were measured by self-report or actigraphy approximately 2 years later. Multivariable regression models accounting for study design (stratification and clustering) were used to examine associations of neighborhood variables with individual sleep dimensions and a multidimensional sleep health composite score. RESULTS: Neighborhood characteristics were not significantly associated with the multidimensional sleep health composite, and there were few significant associations with individual sleep dimensions. Greater levels of air pollution (B = 9.03, 95% CI: 1.16, 16.91) were associated with later sleep midpoint, while greater social disorder (B = -6.90, 95% CI: -13.12, -0.67) was associated with earlier sleep midpoint. Lower walkability was associated with more wake after sleep onset (B = -3.58, 95% CI: -7.07, -0.09). CONCLUSIONS: Living in neighborhoods with lower walkability and greater air pollution was associated with worse sleep health, but otherwise findings were largely null. Future research should test these hypotheses in settings with greater variability and investigate mechanisms of these associations.
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- 2024
33. Greater subjective cognitive decline severity is associated with worse memory performance and lower entorhinal cerebral blood flow in healthy older adults
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Nakhla, Marina Z, Bangen, Katherine J, Schiehser, Dawn M, Roesch, Scott, and Zlatar, Zvinka Z
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Biological Psychology ,Health Services and Systems ,Health Sciences ,Psychology ,Neurodegenerative ,Mental Health ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Stroke ,Aging ,Prevention ,Alzheimer's Disease ,Dementia ,Neurosciences ,Brain Disorders ,Acquired Cognitive Impairment ,Behavioral and Social Science ,Clinical Research ,Neurological ,Mental health ,Humans ,Aged ,Cognition ,Cognitive Dysfunction ,Alzheimer Disease ,Neuropsychological Tests ,Cerebrovascular Circulation ,Cardiovascular Diseases ,cognitive complaints ,memory complaints ,arterial spin labeling MRI ,neuropsychology ,memory ,cognitive aging ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Experimental Psychology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveSubjective cognitive decline (SCD) is a potential early risk marker for Alzheimer's disease (AD), but its utility may vary across individuals. We investigated the relationship of SCD severity with memory function and cerebral blood flow (CBF) in areas of the middle temporal lobe (MTL) in a cognitively normal and overall healthy sample of older adults. Exploratory analyses examined if the association of SCD severity with memory and MTL CBF was different in those with lower and higher cardiovascular disease (CVD) risk status.MethodsFifty-two community-dwelling older adults underwent magnetic resonance imaging, neuropsychological testing, and were administered the Everyday Cognition Scale (ECog) to measure SCD. Regression models investigated whether ECog scores were associated with memory performance and MTL CBF, followed by similar exploratory regressions stratified by CVD risk status (i.e., lower vs higher stroke risk).ResultsHigher ECog scores were associated with lower objective memory performance and lower entorhinal cortex CBF after adjusting for demographics and mood. In exploratory stratified analyses, these associations remained significant in the higher stroke risk group only.ConclusionsOur preliminary findings suggest that SCD severity is associated with cognition and brain markers of preclinical AD in otherwise healthy older adults with overall low CVD burden and that this relationship may be stronger for individuals with higher stroke risk, although larger studies with more diverse samples are needed to confirm these findings. Our results shed light on individual characteristics that may increase the utility of SCD as an early risk marker of cognitive decline.
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- 2024
34. 13 December 19–25, 1754
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Frey, Heinrich, primary and Roesch, Gottlieb, additional
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- 2024
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35. Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics
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Bruce R. Stevens and Luiz F. W. Roesch
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Medicine ,Science - Abstract
Abstract The human armpit microbiome is metabolically entangled with skin cell physiology. This “meta-organism” symbiotic mutualism results in sweat either with or without odor (osmidrosis), depending on host ABCC11 gene haplotypes. Apocrine metabolism produces odorless S-glutathione conjugate that is transferred by ABCC11 transporters into secretory vesicles, deglutamylated to S-Cys-Gly-3M3SH thiol, and exuded to skin surface. An anthropogenic clade of skin bacteria then takes up the thiol and bioconverts it to malodorous 3-methyl-3-sulfanylhexan-1-ol (3M3SH). We hypothesized a familial meta-organism association of human ABCC11 gene non-synonymous SNP rs17822931 interplaying with skin microbiome 3M3SH biosynthesis. Subjects were genotyped for ABCC11 SNPs, and their haplotypes were correlated with axilla microbiome DNA sequencing profiles and predicted metagenome functions. A multigeneration family pedigree revealed a Mendelian autosomal recessive pattern: the C allele of ABCC11 correlated with bacterial Cys-S-conjugate β-lyase (PatB) gene known for Staphylococcus hominis biosynthesis of 3M3SH from human precursor; PatB was rescinded in hosts with homozygous TT alleles encoding ABCC11 loss-of-function mutation. We posit that a C allele encoding functional ABCC11 is key to delivering host conjugate precursors that shape heritable skin niche conditions favorable to harboring Staphylococcus having genomics of odor thiol production. This provides existential insights into human evolution and global regional population ancestries.
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- 2024
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36. Harmonizing data across the accelerating colorectal cancer screening and follow-up through implementation science (ACCSIS) program to enhance data quality and promote data sharing
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Sujha Subramanian, Sarah Kobrin, Sonja Hoover, Sylvia Tan, Alison T. Brenner, Janis E. Campbell, Jennifer Hatcher, Bin Huang, Madeleine Jones, Erin S. Kenzie, Helen Lam, David Liebovitz, Shiraz I. Mishra, Meghan C. O’Leary, Kristine N. Ortwine, V. Shane Pankratz, Electra D. Paskett, Michael Pennell, Amanda F. Petrik, and Scott Roesch
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Common data elements ,Harmonization ,Colorectal cancer screening ,Data coordination ,Mixed methods ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The purpose of the Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) Program, a Cancer Moonshot℠ Initiative, is to support research to build the evidence base on multilevel interventions that increase rates of colorectal cancer screening, follow-up, and referral to care to address disparities in colorectal cancer screening. The National Cancer Institute funded eight Research Projects to implement multilevel interventions to improve colorectal cancer screening among communities who traditionally have been medically underserved. To analyze the impact of ACCSIS across Research Projects, the consortium developed a set of common data elements. The purpose of this paper is to describe the process of developing the common data elements to facilitate analysis of ACCSIS data as well as support and inform implementation science research studies. Methods The ACCSIS Data, Design, and Analysis Work Group was tasked with designing common data elements through a review of existing data collection instruments, examination of data elements proposed by the ACCSIS Research Projects, and deliberations on the data required to compare across the Research Projects. ACCSIS Consortium members drafted, revised, and finalized a common data elements document consisting of variables to collect and surveys to administer to evaluate ACCSIS implementation activities and outcomes in a standardized manner across the Research Projects. Results The ACCSIS Consortium decided to collect the following categories of common data elements: characteristics across multiple levels of the multicomponent interventions, implementation climate, and determinants; interventions and strategies; implementation outcome constructs and definitions; colorectal cancer screening episodes (screening, diagnostic testing follow-up, cancer detection, and cancer treatment); and cost measures. To assess implementation climate, the consortium prioritized constructs from five domains of the Consolidated Framework for Implementation Research. Conclusions The ACCSIS common data elements offer a set of harmonization data for future implementation efforts. The consortium is conducting a systematic assessment using both quantitative and qualitative approaches to assess data quality and approaches to improve and sustain data collection. Lessons learned from these ongoing activities will offer additional insights to tailor the ACCSIS common data elements and support efforts to increase colorectal cancer screening for populations experiencing disparities.
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- 2024
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37. Continuous arterial blood pressure indices and early hematoma expansion in patients with spontaneous intracerebral hemorrhage
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Annerose Mengel, Vasileios Siokas, Rebecca Buesink, Sara Roesch, Kornelia Laichinger, Redina Ferizi, Efthimios Dardiotis, Patricia Schwarz, Jennifer Sartor-Pfeiffer, Constanze Single, Antje Giede-Jeppe, Till-Karsten Hauser, Sven Poli, Markus Krumbholz, Ulf Ziemann, and Katharina Feil
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Intracerebral hemorrhage ,Blood pressure variability ,Hematoma expansion ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Objective: Blood pressure variability (BPV) and its potential association with early hematoma expansion (HE) in intracerebral hemorrhage (ICH) remains to be fully elucidated. Our study explores the potential link between BPV within the first 24 h after admission and HE in ICH. Methods: In a prospective cohort single-center study, we analyzed consecutive patients with spontaneous ICH. Continuous BP data via an arterial line extracted from the Intellispace Critical Care and Anesthesia information system (Philips Healthcare) were analyzed over 0–2, 0–8, 0–12, and 0–24 h intervals post-admission. BPV was assessed through successive variability (SV), standard deviation (SD), and coefficient of variation (CV) using all available BP measurements. Early HE was defined as an absolute [≥ 6 ml] or relative [≥ 33 %] increase in ICH volume on 24-hours follow-up brain imaging. Secondary endpoints were the influence of BP on admission and other potential risk factors for HE. Results: Among 305 ICH-patients (mean age ± SD 70.1 ± 14.9 years, 47.9 % female, median NIHSS 6 (3, 13), median ICH score 1 (1, 2)), 41 (13.4 %) experienced HE. HE-patients had higher NIHSS (p = 0.015), ICH-score (p = 0.005), ICH volume (p 30 cm3) experienced lower absolute BP and BPV indices and worse clinical outcomes. These findings suggest a nuanced relationship between BP dynamics and ICH severity, underscoring the need for individualized BP management in acute ICH care. Further research is necessary to explore these relationships and optimize treatment strategies.
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- 2024
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38. The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken
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Vincent Saint-Martin, Vanaique Guillory, Mélanie Chollot, Isabelle Fleurot, Emmanuel Kut, Ferdinand Roesch, Ignacio Caballero, Emmanuelle Helloin, Emilie Chambellon, Brian Ferguson, Philippe Velge, Florent Kempf, Sascha Trapp, and Rodrigo Guabiraba
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Biology (General) ,QH301-705.5 - Abstract
Abstract The gut microbiota exerts profound influence on poultry immunity and metabolism through mechanisms that yet need to be elucidated. Here we used conventional and germ-free chickens to explore the influence of the gut microbiota on transcriptomic and metabolic signatures along the gut-lung axis in poultry. Our results demonstrated a differential regulation of certain metabolites and genes associated with innate immunity and metabolism in peripheral tissues of germ-free birds. Furthermore, we evidenced the gut microbiota’s capacity to regulate mucosal immunity in the chicken lung during avian influenza virus infection. Finally, by fine-analysing the antiviral pathways triggered by the short-chain fatty acid (SCFA) butyrate in chicken respiratory epithelial cells, we found that it regulates interferon-stimulated genes (ISGs), notably OASL, via the transcription factor Sp1. These findings emphasize the pivotal role of the gut microbiota and its metabolites in shaping homeostasis and immunity in poultry, offering crucial insights into the mechanisms governing the communication between the gut and lungs in birds.
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- 2024
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39. The Development, Validity, and Reliability of a Brief Self-Report Measure of Family Resilience in Military Families
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Travis N. Ray, Alejandro P. Esquivel, Valerie A. Stander, Hope S. McMaster, Scott C. Roesch, and Froma Walsh
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Objective: This study aimed to develop a brief and valid measure of family resilience for use in research with military families. Method: A population-based sample of military spouses (N = 16,379) completed assessments of family resilience and validation constructs. Participants were randomized into two subsamples. Subsample 1 was used in a factor analysis to reduce the number of items, whereas subsample 2 was used in a series of models to confirm the initial model and evaluate dimensionality, reliability, and validity. Results: Nine items were retained and demonstrated strong factor loadings (> 0.80) in the initial and confirmatory models. A bifactor model provided some evidence of multidimensionality, but not enough to dismiss the unidimensional construct. Brief measures of family resilience and its subconstructs demonstrated strong reliability and construct validity. Conclusions: The 9-item instrument is a reliable and valid tool that can be used to assess military family resilience in future research.
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- 2024
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40. VLBI Probes of Jet Physics in Neutrino-Candidate Blazars
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Eppel, F., Kadler, M., Ros, E., Benke, P., Giroletti, M., Hessdoerfer, J., McBride, F., and Roesch, F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
In recent years, evidence has accumulated that some high-energy cosmic neutrinos can be associated with blazars. The strongest evidence for an individual association was found in the case of the blazar TXS 0506+056 in 2017. In July 2019, another track-like neutrino event (IC190730A) was found spatially coincident with the well-known bright flat-spectrum radio quasar PKS 1502+106. PKS 1502+106 was not found to be in a particularly elevated gamma-ray state, but exhibited a remarkably bright radio outburst at the time of the neutrino detection, similar to TXS 0506+056. We have performed a multi-frequency VLBI study from 15 GHz up to 86 GHz on TXS 0506+056, PKS 1502+106 and one additional neutrino-candidate blazar (PKS 0215+015) to study the radio structure of neutrino candidate blazars in response to their neutrino association. We have obtained target of opportunity observations with the VLBA for all three sources within $\sim$1 month from their associated neutrino events and are performing multi-epoch studies of the jet kinematics at 15 GHz as part of the MOJAVE program. Here, we present first results on TXS 0506+056 at 86 GHz and one additional 43 GHz image obtained 27 days after IC170922A, closer in time to the neutrino event than previously published images. We also give an overview about our recent work on PKS 1502+106 and PKS 0215+015., Comment: 8 pages, 1 figure, 1 table, Proceedings of 38th International Cosmic Ray Conference (ICRC2023)
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- 2023
41. Hub-and-Spoke centralized intervention to optimize colorectal cancer screening and follow-up: A pragmatic, cluster-randomized controlled trial protocol
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Castañeda, Sheila F, Gupta, Samir, Nodora, Jesse N, Largaespada, Valesca, Roesch, Scott C, Rabin, Borsika A, Covin, Jennifer, Ortwine, Kristine, Preciado-Hidalgo, Yesenia, Howard, Nicole, Halpern, Michael T, and Martinez, Maria Elena
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Biomedical and Clinical Sciences ,Health Services and Systems ,Public Health ,Health Sciences ,Clinical Sciences ,Minority Health ,Colo-Rectal Cancer ,Comparative Effectiveness Research ,Aging ,Prevention ,Health Services ,Dissemination and Implementation Research ,Clinical Research ,Health Disparities ,Digestive Diseases ,Social Determinants of Health ,Cancer ,Clinical Trials and Supportive Activities ,Women's Health ,Behavioral and Social Science ,4.4 Population screening ,Humans ,Early Detection of Cancer ,Mass Screening ,Colorectal Neoplasms ,Ambulatory Care Facilities ,Community Health Centers ,Occult Blood ,Randomized Controlled Trials as Topic ,Community health centers ,Colorectal cancer screening ,Abnormal fecal immunochemical test follow-up ,Cancer disparities ,Medical and Health Sciences ,General Clinical Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundGuidelines recommend screening for colorectal cancer (CRC), but participation and abnormal test follow up rates are suboptimal, with disparities by demography. Evidence-based interventions exist to promote screening, but community adoption and implementation are limited.MethodsThe San Diego Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) program is an academic-community partnership testing regional implementation of a Hub-and-Spoke model for increasing CRC screening and follow-up. The "hub" is a non-academic, non-profit organization that includes 17 community health center (CHC) systems, serving over 190 rural and urban clinic sites. The "spokes" are 3 CHC systems that oversee 11-28 clinics each, totaling over 60 clinics. Using a cluster-randomized trial design, 9 clinics were randomized to intervention and 16 to usual care. Within intervention clinics, approximately 5000 eligible patients not up-to-date with CRC screening per year were identified for intervention. Interventions include an invitation primer, a mailed fecal immunochemical test with completion instructions, and phone and text-based reminders (hub) and patient navigation protocol to promote colonoscopy completion after abnormal FIT (spoke). Outcomes include: 1) proportion of patients up-to-date with screening after three years in intervention versus non-intervention clinics; 2) proportion of patients with abnormal FIT completing colonoscopy within six months of the abnormal result. Implementation science measures are collected to assess acceptability, intervention and usual care adaptations, and sustainability of the intervention strategies.ConclusionThis large-scale, regional cluster randomized trial among CHCs serving diverse populations is anticipated to accelerate progress in CRC prevention in underserved populations.Trial registrationNCT04941300.
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- 2023
42. Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics
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Stevens, Bruce R. and Roesch, Luiz F. W.
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- 2024
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43. Harmonizing data across the accelerating colorectal cancer screening and follow-up through implementation science (ACCSIS) program to enhance data quality and promote data sharing
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Subramanian, Sujha, Kobrin, Sarah, Hoover, Sonja, Tan, Sylvia, Brenner, Alison T., Campbell, Janis E., Hatcher, Jennifer, Huang, Bin, Jones, Madeleine, Kenzie, Erin S., Lam, Helen, Liebovitz, David, Mishra, Shiraz I., O’Leary, Meghan C., Ortwine, Kristine N., Pankratz, V. Shane, Paskett, Electra D., Pennell, Michael, Petrik, Amanda F., and Roesch, Scott
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- 2024
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44. The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken
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Saint-Martin, Vincent, Guillory, Vanaique, Chollot, Mélanie, Fleurot, Isabelle, Kut, Emmanuel, Roesch, Ferdinand, Caballero, Ignacio, Helloin, Emmanuelle, Chambellon, Emilie, Ferguson, Brian, Velge, Philippe, Kempf, Florent, Trapp, Sascha, and Guabiraba, Rodrigo
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- 2024
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45. Proteomic analysis of the urothelial cancer landscape
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Dressler, Franz F., Diedrichs, Falk, Sabtan, Deema, Hinrichs, Sofie, Krisp, Christoph, Gemoll, Timo, Hennig, Martin, Mackedanz, Paulina, Schlotfeldt, Mareile, Voß, Hannah, Offermann, Anne, Kirfel, Jutta, Roesch, Marie C., Struck, Julian P., Kramer, Mario W., Merseburger, Axel S., Gratzke, Christian, Schoeb, Dominik S., Miernik, Arkadiusz, Schlüter, Hartmut, Wetterauer, Ulrich, Zubarev, Roman, Perner, Sven, Wolf, Philipp, and Végvári, Ákos
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- 2024
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46. Longitudinal association between fitness and metabolic syndrome: a population-based study over 29 years follow-up
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Wiemann, Johannes, Krell-Roesch, Janina, Woll, Alexander, and Boes, Klaus
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- 2024
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47. Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection
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Lucot-Royer, Louise, Nallet, Camille, Vouga, Manon, Puyraveau, Marc, Mauny, Frederic, Marty-Quinternet, Solène, Bertholdt, Charline, Bory, Jean-Paul, Devalland, Christine, Canaguier, Margaux, Copolla, Camille, Eszto, Marie-Laure, Montoya, Yohny, Roesch, Marion, Reviron, Sandrine, Riethmuller, Didier, Rufenacht, Emma, Simon, Emmanuel, and Mottet, Nicolas
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- 2024
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48. Randomized Feasibility Pilot of an Executive Functioning Intervention Adapted for Children’s Mental Health Settings
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Dickson, Kelsey S., Galligan, Megan, Holt, Tana, Kenworthy, Lauren, Anthony, Laura, Roesch, Scott, and Brookman-Frazee, Lauren
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- 2024
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49. Rigidity of non-renormalizable Newton maps
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Roesch, Pascale, Yin, Yongcheng, and Zeng, Jinsong
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- 2024
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50. TREM2 protects from atherosclerosis by limiting necrotic core formation
- Author
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Piollet, Marie, Porsch, Florentina, Rizzo, Giuseppe, Kapser, Frederieke, Schulz, Dirk J. J., Kiss, Máté G., Schlepckow, Kai, Morenas-Rodriguez, Estrella, Sen, Mustafa Orkun, Gropper, Julius, Bandi, Sourish Reddy, Schäfer, Sarah, Krammer, Tobias, Leipold, Alexander M., Hoke, Matthias, Ozsvár-Kozma, Mária, Beneš, Hannah, Schillinger, Martin, Minar, Erich, Roesch, Melanie, Göderle, Laura, Hladik, Anastasiya, Knapp, Sylvia, Colonna, Marco, Martini, Rudolf, Saliba, Antoine-Emmanuel, Haass, Christian, Zernecke, Alma, Binder, Christoph J., and Cochain, Clément
- Published
- 2024
- Full Text
- View/download PDF
Catalog
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