33 results on '"Rodriguez-Valero, N"'
Search Results
2. Corrigendum to “Host biomarkers for early identification of severe imported Plasmodium falciparum malaria” [Trav. Med. Infect. Dis. 54 (2023) 102608]
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Balerdi-Sarasola, L., Parolo, C., Fleitas, P., Cruz, A., Subirà, C., Rodríguez-Valero, N., Almuedo-Riera, A., Letona, L., Álvarez-Martínez, M.J., Valls, M Eugenia, Vera, I., Mayor, A., Muñoz, J., and Camprubí-Ferrer, D.
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- 2024
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3. Telemedicine for international travelers through a Smartphone-based monitoring platform (Trip Doctor®)
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Rodriguez-Valero, N., primary, Carbayo, MJ Ledesma, additional, Camprubí-Ferrer, D., additional, Martí-Soler, H., additional, Sanchez, D. Cuadrado, additional, Vladimirov, A., additional, Pinazo, M.J., additional, Almuedo-Riera, A., additional, Roman, A., additional, Vera, I., additional, Roldan, M., additional, de Alba, T., additional, Jimenez, A., additional, Gómez-Valverde, Juan J., additional, Oroz, M Luengo, additional, and Muñoz, J., additional
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- 2022
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4. Causes of fever in returning travelers: a European multicenter prospective cohort study
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Camprubi-Ferrer D, Cobuccio L, Van den Broucke S, Genton B, Bottieau E, D'Acremont V, Rodriguez-Valero N, Almuedo-Riera A, Balerdi-Sarasola L, Subira C, Fernandez-Pardos M, Martinez M, Navero-Castillejos J, Vera I, Llenas-Garcia J, Rothe C, Cadar D, Van Esbroeck M, Foque N, and Munoz J
- Abstract
Background Etiological diagnosis of febrile illnesses in returning travelers is a great challenge, particularly when presenting with no focal symptoms [acute undifferentiated febrile illnesses (AUFI)], but is crucial to guide clinical decisions and public health policies. In this study, we describe the frequencies and predictors of the main causes of fever in travelers. Methods Prospective European multicenter cohort study of febrile international travelers (November 2017-November 2019). A predefined diagnostic algorithm was used ensuring a systematic evaluation of all participants. After ruling out malaria, PCRs and serologies for dengue, chikungunya and Zika viruses were performed in all patients presenting with AUFI
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- 2022
5. 316 - Consejos médicos para viajeros
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Muñoz Gutiérrez, J., Vilella I Morató, A., and Rodríguez Valero, N.
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- 2020
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6. Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections
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Rojo-Marcos, G., Rubio-Munoz, J. M., Angheben, A., Jaureguiberry, S., Garcia-Bujalance, S., Tomasoni, L. R., Rodriguez-Valero, N., Ruiz-Giardin, J. M., Salas-Coronas, J., Cuadros-Gonzalez, J., Garcia-Rodriguez, M., Molina-Romero, I., Lopez-Velez, R., Gobbi, F., Calderon-Moreno, M., Martin-Echevarria, E., Elia-Lopez, M., Llovo-Taboada, J., Lago-Nunez, M., Castelli, F., Jaquetti, J., Alonso, C., Camprubi, D., Gorgolas-Hernandez-Mora, M., Cuevas-Tascon, G., Perez-Ayala, A., Guzman-Garciamonge, M. T., Ribell-Bachs, M., Serre-Delcor, N., Martin-Martin, Y., Ramirez-Olivencia, G., Cogollos-Agruna, R., Merino-Fernandez, F. J., Garcia-Castro, A., Cantudo-Munoz, P., Belhassen-Garcia, M., Martin-Rabadan, P., Rubio-Cuevas, P., Trigo-Esteban, E., and Arevalo-Serrano, J.
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0301 basic medicine ,Male ,Plasmodium ovale ,Plasmodium ovale curtisi ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Diabetes mellitus ,Communicable Diseases, Imported ,Epidemiology ,Prevalence ,Prospective Studies ,Antimalarials ,Comparative study ,INR ,Plasmodium ovale wallikeri ,Thrombocytopenia ,Adult ,Africa ,Europe ,Female ,Genotype ,Humans ,Incidence ,Malaria ,Middle Aged ,Sex Factors ,Species Specificity ,Young Adult ,Rapid diagnostic test ,biology ,digestive, oral, and skin physiology ,Infectious Diseases ,Chemoprophylaxis ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,030231 tropical medicine ,Communicable Diseases ,digestive system ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,stomatognathic system ,Internal medicine ,parasitic diseases ,medicine ,lcsh:RC109-216 ,Risk factor ,business.industry ,Research ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,Imported ,chemistry ,Parasitology ,Artesunate ,business - Abstract
BACKGROUND: Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences. METHODS: Patients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods. RESULTS: A total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi. CONCLUSIONS: Imported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection. This study has been funded with a grant FIB-PI14-04 from the Foundation for Biomedical Research of the Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain. Sí
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- 2018
7. Mirroring the Zika epidemics in Cuba: The view from a European imported diseases clinic
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Almuedo-Riera, A., primary, Rodriguez-Valero, N., additional, Camprubí, D., additional, Losada Galván, I., additional, Zamora-Martinez, C., additional, Pousibet-Puerto, J., additional, Subirà, C., additional, Martinez, M.J., additional, Pinazo, M.J., additional, and Muñoz, J., additional
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- 2019
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8. TRIP (Travel Remote Infomation Platform) - a platform for monitoring traveler's health
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Rodriguez-Valero, N., María J. Ledesma-Carbayo, Cuadrado Sanchez, D., Vladimorov, A., Vera, I., Roldan, M., Alba, T., Sanz, S., Luengo Oroz, M., and Munoz, J.
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Telecomunicaciones ,Medicina ,Electrónica ,human activities - Abstract
Most of the studies reporting symptoms during the travel are done retrospectively (1),(2), increasing the odds of recall bias. Moreover, there is no information about the percentage of travelers that suffer mild or no symptoms during their trips because they never attend to a clinic afterwards. A IM The main aim of the study is to detect incidence of symptoms real-time amongst travelers visiting tropical and subtropical countries. Also, comparing symptoms between travelers taking or not malaria chemoprophylaxis and other demographic variables.
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- 2017
9. Real-time incidence of travel-related symptoms through a smartphone-based app remote monitoring system: a pilot study
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Rodriguez-Valero, N, primary, Carbayo, M J Ledesma, additional, Sanchez, D Cuadrado, additional, Vladimirov, A, additional, Espriu, M, additional, Vera, I, additional, Roldan, M, additional, de Alba, T, additional, Sanz, S, additional, Moreno, J L Gonzalez, additional, Oroz, M Luengo, additional, and Muñoz, J, additional
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- 2018
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10. Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate
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Rodriguez-Valero, N, primary, Castro, P, additional, Martinez, G, additional, Marco Hernandez, J, additional, Fernandez, S, additional, Gascon, J, additional, and Nicolas, J M, additional
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- 2017
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11. Brote de carbunco en una zona rural de Etiopía
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Rodríguez-Valero, N., Esquivias, M., Plans, E., Tesfamariam, A., Reyes-Rabell, F., and Ramos-Rincón, J.M.
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- 2012
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12. Mirroring the Zika epidemics in Cuba: The view from a European imported diseases clinic.
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Rodriguez-Valero, N., Camprubí, D., Losada Galván, I., Zamora-Martinez, C., Pousibet-Puerto, J., Subirà, C., Martinez, M.J., Pinazo, M.J., Muñoz, J., and Almuedo-Riera, A.
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- 2019
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13. Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate.
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Rodriguez-Valero, N, Castro, P, Martinez, G, Hernandez, J Marco, Fernandez, S, Gascon, J, Nicolas, J M, and Marco Hernandez, J
- Abstract
Blackwater fever was typically reported after quinine administration, although it is poor recognized in patients receiving artesunate. This case describes a blackwater fever in a non-immune patient after artesunate for severe malaria. It highlights the importance of monitoring haemolytic parameters in severe malaria to avoid renal impairment or severe anaemia. [ABSTRACT FROM AUTHOR]
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- 2018
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14. Paederus dermatitis after travelling: a case of misdiagnosis and clinical resolution.
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Calderón CF, Rodriguez-Valero N, and Vera I
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- 2024
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15. Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions?
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Balerdi-Sarasola L, Muñoz J, Fleitas P, Rodriguez-Valero N, Almuedo-Riera A, Antequera A, Subirà C, Grafia-Perez I, Ortiz-Fernández M, de Alba T, Álvarez-Martínez MJ, Valls ME, Parolo C, Castro P, and Camprubí-Ferrer D
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- Humans, Male, Female, Adult, Middle Aged, Cohort Studies, Adolescent, Child, Preschool, Child, Parasitemia epidemiology, Young Adult, Coinfection epidemiology, Aged, Infant, Malaria epidemiology, Malaria diagnosis, Malaria complications, Severity of Illness Index
- Abstract
Background: The current definition of severe malaria in non-endemic areas follows WHO criteria, which mainly target children in malaria-endemic areas, potentially misclassifying cases in non-endemic regions. We assessed the performance of a modified severe malaria classification criteria within our patient cohort., Methods: A cohort study of patients managed for malaria in a non-endemic setting (2005-2023) was analyzed. We classified patients into severe malaria (SM) using WHO 2013 criteria except for hyperparasitemia, where 2 % threshold was applied. Patients with SM were distinguished as very severe malaria (VSM) when presenting at least one of the following conditions: parasitemia >10 %, pulmonary edema, impaired consciousness, seizures, renal failure, metabolic acidosis or hyperlactatemia, shock or hypoglycemia. In patients with SM and no criteria for VSM, less severe malaria (LSM) was defined by: 2-10 % parasitemia, hyperbilirubinemia, prostration, anemia or minor bleeding. The primary composite outcome was death or the need for a life-saving intervention, as analyzed in the three comparative groups. Secondary outcome was the prevalence of co-infections., Results: Among 506 patients with malaria, 176 (34.8 %) presented with SM. A total of 37 (7.3 %) patients developed a life-threatening condition, namely death (n = 4) and/or the need for life-saving interventions (n = 34). All fatalities and 33 out of the 34 life-saving interventions occurred in the VSM group. Patients in LSM group did not develop any life-threatening conditions. As to co-infections, 28 (5.5 %) patients had a community-acquired co-infection, with no differences between groups (p = 0.763)., Conclusions: Severity criteria definitions would benefit from a review when assessing patients with malaria in non-endemic areas. Within the spectrum of SM, patients reclassified as LSM have a low risk of developing a life-threatening condition and present low co-infection incidence and could benefit from management out of intensive care units and a restrictive use of empirical antibiotics., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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16. A Smartphone App for Real-Time Assessment of Malaria Prophylaxis Adverse Events.
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Rodriguez-Valero N, Ledesma-Carbayo MJ, Martí-Soler H, Cuadrado Sanchez D, Vladimirov A, Camprubí-Ferrer D, Pinazo MJ, Losada I, Almuedo-Riera A, Romero L, Roman A, Vera I, Roldan-Torralvo M, Ferrer E, de Alba T, Jimenez A, Gómez-Valverde JJ, Muñoz J, and Luengo Oroz M
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- Humans, Female, Male, Adult, Middle Aged, Spain, Travel, Medication Adherence statistics & numerical data, Young Adult, Malaria prevention & control, Smartphone, Mobile Applications, Antimalarials adverse effects, Antimalarials administration & dosage, Antimalarials therapeutic use
- Abstract
Background: n Growth of international travel to malarial areas over the last decades has contributed to more travelers taking malaria prophylaxis. Travel-related symptoms may be wrongly attributed to malaria prophylaxis and hinder compliance. Here, we aimed to assess the frequency of real-time reporting of symptoms by travelers following malaria prophylaxis using a smartphone app. Method: Adult international travelers included in this single-center study (Barcelona, Spain) used the smartphone Trip Doctor
® app developed by our group for real-time tracking of symptoms and adherence to prophylaxis. Results: Six hundred four ( n = 604) international travelers were included in the study; 74.3% (449) used the app daily, and for one-quarter of travelers, malaria prophylaxis was prescribed. Participants from the prophylaxis group traveled more to Africa (86.7% vs. 4.3%; p < 0.01) and to high travel medical risk countries (60.8% vs. 18%; p < 0.01) and reported more immunosuppression (30.8% vs. 23.1% p < 0.01). Regarding symptoms, no significant intergroup differences were observed, and no relationship was found between the total number of malarial pills taken and reported symptoms. Conclusions: In our cohort, the number of symptoms due to malaria prophylaxis was not significantly higher than in participants for whom prophylaxis was not prescribed, and the overall proportion of symptoms is higher compared with other studies.- Published
- 2024
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17. A skin comet sign after a trip to the Gambia.
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Rodriguez-Valero N, Sarasola Balerdi L, Vera I, de Alba T, Saloni M, and Camprubí-Ferrer D
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- Humans, Gambia, Skin, Travel
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- 2024
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18. Scalp myiasis presenting as forehead edema in a returning traveller from Belize: A diagnostic challenge.
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Martínez-Lacalzada M, Vera I, Álvarez-Martínez MJ, Aylagas C, and Rodriguez-Valero N
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- Animals, Humans, Belize, Scalp, Forehead, Edema, Larva, Travel, Myiasis diagnosis, Diptera
- Abstract
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
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- 2024
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19. Characterization of Latin American migrants at risk for Trypanosoma cruzi infection in a non-endemic setting. Insights into initial evaluation of cardiac and digestive involvement.
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Laynez-Roldán P, Losada-Galván I, Posada E, de la Torre Ávila L, Casellas A, Sanz S, Subirà C, Rodriguez-Valero N, Camprubí-Ferrer D, Vera I, Roldán M, Aldasoro E, Oliveira-Souto I, Calvo-Cano A, Valls ME, Álvarez-Martínez MJ, Gállego M, Abras A, Ballart C, Muñoz J, Gascón J, and Pinazo MJ
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- Humans, Female, Male, Latin America epidemiology, Heart, Transients and Migrants, Chagas Disease diagnosis, Trypanosoma cruzi
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Background: Trypanosoma cruzi causes Chagas disease (CD), a potentially fatal disease characterized by cardiac disorders and digestive, neurological or mixed alterations. T. cruzi is transmitted to humans by the bite of triatomine vectors; both the parasite and disease are endemic in Latin America and the United States. In the last decades, population migration has changed the classic epidemiology of T. cruzi, contributing to its global spread to traditionally non-endemic countries. Screening is recommended for Latin American populations residing in non-endemic countries., Methods: The present study analyzes the epidemiological characteristics of 2,820 Latin American individuals who attended the International Health Service (IHS) of the Hospital Clinic de Barcelona between 2002 and 2019. The initial assessment of organ damage among positive cases of T. cruzi infection was analyzed, including the results of electrocardiogram (ECG), echocardiogram, barium enema and esophagogram., Results: Among all the screened individuals attending the clinic, 2,441 (86.6%) were born in Bolivia and 1,993 (70.7%) were female. Of individuals, 1,517 (81.5%) reported previous exposure to the vector, which is a strong risk factor associated with T. cruzi infection; 1,382 individuals were positive for T. cruzi infection. The first evaluation of individuals with confirmed T. cruzi infection, showed 148 (17.1%) individuals with Chagasic cardiomyopathy, the main diagnostic method being an ECG and the right bundle branch block (RBBB) for the most frequent disorder; 16 (10.8%) individuals had a normal ECG and were diagnosed of Chagasic cardiomyopathy by echocardiogram., Conclusions: We still observe many Latin American individuals who were at risk of T. cruzi infection in highly endemic areas in their countries of origin, and who have not been previously tested for T. cruzi infection. In fact, even in Spain, a country with one of the highest proportion of diagnosis of Latin American populations, T. cruzi infection remains underdiagnosed. The screening of Latin American populations presenting with a similar profile as reported here should be promoted. ECG is considered necessary to assess Chagasic cardiomyopathy in positive individuals, but echocardiograms should also be considered as a diagnostic approach given that it can detect cardiac abnormalities when the ECG is normal., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Laynez-Roldán et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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20. Clinical evaluation of BioFire® multiplex-PCR panel for acute undifferentiated febrile illnesses in travellers: a prospective multicentre study.
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Camprubí-Ferrer D, Cobuccio L, Van Den Broucke S, Balerdi-Sarasola L, Genton B, Bottieau E, Navero-Castillejos J, Martinez MJ, Jay C, Grange A, Borland S, Vaughn M, Rodriguez-Valero N, Almuedo-Riera A, D'Acremont V, Subirà C, de Alba T, Cruz A, Van Esbroeck M, Smith C, Hillman A, Hanberg B, Trauscht R, Spampanato N, and Muñoz J
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- Adult, Humans, Travel, Prospective Studies, Travel-Related Illness, Fever etiology, Multiplex Polymerase Chain Reaction, Chikungunya Fever diagnosis, Malaria diagnosis, Malaria complications, Rickettsia, Dengue diagnosis, Dengue complications, Zika Virus, Zika Virus Infection
- Abstract
Background: Identifying the causes of Acute Undifferentiated Febrile Illness (AUFI) is key to improve the management of returning travellers with fever. We evaluated a BioFire®FilmArray® prototype panel of multiplex nucleic acid amplification tests (NAAT) targeting different relevant pathogens in travellers returning with fever., Methods: Prospective, multicentre study to evaluate a prototype panel in whole blood samples of adult international travellers presenting with AUFI in three European travel Clinics/Hospitals (November 2017-November 2019). We evaluated 15 target analytes: Plasmodium spp., Plasmodium falciparum, Plasmodium knowlesi, Plasmodium malariae, Plasmodium ovale, Plasmodium vivax, chikungunya virus, dengue virus, Zika virus, Anaplasma phagocytophilum, Borrelia spp., Leptospira spp., Orientia tsutsugamushi, Rickettsia spp. and Salmonella spp. Results were compared with composite reference standards (CRSs) for each target infection, including direct methods [smear microscopy, rapid diagnostic test (RDT), reference NAAT and blood cultures] and indirect methods (paired serology)., Findings: Among 455 travellers with AUFI, 229 target infections were diagnosed; the prototype panel detected 143 (overall sensitivity and specificity of 62.5 and 99.8%, respectively). The panel identified all Plasmodium infections (n = 82). Sensitivity for dengue (n = 71) was 92.9, 80.8 and 68.5% compared with RDT, NAAT and CRS, respectively. Compared with direct methods and CRS, respectively, the prototype panel detected 4/4 and 4/6 chikungunya, 2/2 and 4/29 Leptospira spp., 1/1 and 1/6 O. tsutsugamushi and 2/2 and 2/55 Rickettsia spp., but 0/2 and 0/10 Zika, 0/1 and 0/11 A. phagocytophylum and 0/3 Borrelia spp. diagnosed by serology and only 1/7 Salmonella spp. diagnosed by blood cultures. 77/86 (89.5%) infections not detected by the panel were diagnosed by serology., Interpretation: The prototype panel allowed rapid and reliable diagnosis for malaria, dengue and chikungunya. Further improvements are needed to improve its sensitivity for Zika and important travel-related bacterial infections., (© International Society of Travel Medicine 2023. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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21. Doxycycline responding illnesses in returning travellers with undifferentiated non-malaria fever: a European multicentre prospective cohort study.
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Camprubí-Ferrer D, Oteo JA, Bottieau E, Genton B, Balerdi-Sarasola L, Portillo A, Cobuccio L, Van Den Broucke S, Santibáñez S, Cadar D, Rodriguez-Valero N, Almuedo-Riera A, Subirà C, d'Acremont V, Martinez MJ, Roldán M, Navero-Castillejos J, Van Esbroeck M, and Muñoz J
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- Humans, Doxycycline, Prospective Studies, Cohort Studies, Fever etiology, Rickettsia, Malaria complications, Dengue complications
- Abstract
Background: Diagnosis of undifferentiated non-malaria fevers (NMF) in returning travellers is a great challenge. Currently, there is no consensus about the use of empirical antibiotics in returning travellers with undifferentiated NMF. Although studies in endemic areas showed that a wide range of pathogens implicated in undifferentiated NMF are treatable with doxycycline, the role of doxycycline in returning travellers with fever still has to be explored., Methods: Prospective European multicentre cohort study of febrile international travellers (November 2017-November 2019). Immunological and molecular diagnostic techniques for doxycycline responding illnesses (DRI) agents such as Anaplasma phagocytophilum, spotted fever group Rickettsia spp., typhus group Rickettsia spp., Coxiella burnetii, Bartonella spp., Orientia tsutsugamushi, Borrelia miyamotoi, Borrelia recurrentis and Leptospira spp. were systematically performed in all patients with undifferentiated NMF. We estimated the prevalence and predictive factors of DRI in returning travellers with undifferentiated NMF., Results: Among 347 travellers with undifferentiated NMF, 106 (30·5%) were finally diagnosed with DRI. Only 57 (53·8%) of the 106 DRI infections were diagnosed by the standard of care. The main causes of DRI were: 55 (51·9%) Rickettsia spp., 16 (15·1%) C. burnetii; 15 (14·2%) Bartonella spp.; 13 (12·3%) Leptospira spp. and 10 (9·5%) A. phagocytophilum. The only predictive factor associated with DRI was presenting an eschar (aOR 39·52, 95%CI 4·85-322·18). Features of dengue such as retro-orbital pain (aOR 0·40, 95%CI 0·21-0·76) and neutropenia (aOR 0·41, 95%CI 0·21-0·79) were negatively associated with DRI., Conclusions: Although DRI are responsible for 30% of undifferentiated NMF cases in travellers, those are seldom recognized during the first clinical encounter. Empirical treatment with doxycycline should be considered in returning travellers with undifferentiated fever and negative tests for malaria and dengue, particularly when presenting severe illness, predictive factors for rickettsiosis or no features of dengue., (© The Author(s) 2022. Published by Oxford University Press on behalf of International Society of Travel Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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22. Improving the diagnosis and management of acute schistosomiasis with antibody, antigen and molecular techniques: lessons from a cluster of six travellers.
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Camprubí-Ferrer D, Romero L, Van Esbroeck M, Wammes LJ, Almuedo-Riera A, Rodriguez-Valero N, Balerdi-Sarasola L, Hoekstra PT, Subirà C, Valls ME, Micalessi I, Corstjens P, Cortes-Serra N, Huyse T, Benegas M, Álvarez-Martínez MJ, Muñoz J, and van Lieshout L
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- Animals, Antigens, Helminth, Enzyme-Linked Immunosorbent Assay, Humans, Schistosoma mansoni, Schistosomiasis diagnosis, Schistosomiasis therapy, Schistosomiasis mansoni
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- 2021
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23. Blister beetle dermatitis with mirror lesions in a cluster of travellers from Kenya.
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Camprubí-Ferrer D, Rodriguez-Valero N, Muelas M, Almuedo-Riera A, Romero L, and Muñoz J
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- Animals, Humans, Kenya, Coleoptera, Dermatitis
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- 2021
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24. Incidence of human granulocytic anaplasmosis in returning travellers with fever.
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Camprubí-Ferrer D, Portillo A, Santibáñez S, Almuedo-Riera A, Rodriguez-Valero N, Subirà C, Martinez MJ, Navero-Castillejos J, Fernandez-Pardos M, Genton B, Cobuccio L, Van Den Broucke S, Bottieau E, Muñoz J, and Oteo JA
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- Animals, Doxycycline therapeutic use, Humans, Incidence, Prospective Studies, Anaplasma phagocytophilum, Anaplasmosis diagnosis, Anaplasmosis drug therapy, Anaplasmosis epidemiology
- Abstract
Background: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown., Methods: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever., Results: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA., Conclusions: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever., (© International Society of Travel Medicine 2021. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
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- 2021
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25. Malaria prophylaxis approach during COVID-19 pandemic.
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Rodriguez-Valero N, Vera I, Torralvo MR, De Alba T, Ferrer E, Camprubi D, Almuedo Riera A, Gallego RS, Muelas M, Pinazo MJ, and Muñoz J
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- COVID-19 prevention & control, Chloroquine therapeutic use, Drug Resistance, Humans, Hydroxychloroquine therapeutic use, Malaria drug therapy, Pre-Exposure Prophylaxis, COVID-19 epidemiology, Malaria prevention & control, SARS-CoV-2
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- 2020
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26. Post-splenectomy acute glomerulonephritis due to a chronic infection with Plasmodium falciparum and malariae.
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Camprubí D, Balerdi L, Quintana LF, Almuedo-Riera A, Valls ME, García-Herrera A, Rodriguez-Valero N, Alvarez-Martínez MJ, and Muñoz J
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- Adult, Humans, Male, Plasmodium falciparum, Plasmodium malariae, Glomerulonephritis parasitology, Glomerulonephritis pathology, Malaria complications, Splenectomy
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- 2019
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27. Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence?
- Author
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Camprubí D, Pereira A, Rodriguez-Valero N, Almuedo A, Varo R, Casals-Pascual C, Bassat Q, Malvy D, and Muñoz J
- Subjects
- Administration, Intravenous adverse effects, Adolescent, Adult, Anemia, Hemolytic chemically induced, Coombs Test statistics & numerical data, Female, Humans, Male, Middle Aged, Retrospective Studies, Spain, Anemia, Hemolytic drug therapy, Antimalarials administration & dosage, Artesunate administration & dosage, Hemolysis drug effects, Malaria drug therapy
- Abstract
Background: Delayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing once-infected "pitted" erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. However, an increasing number of cases with positive direct antiglobulin test (DAT) haemolysis after AS have been reported., Methods: All malaria cases seen at Hospital Clinic of Barcelona between 2015 and 2017 were retrospectively reviewed. Clinical, parasitological and laboratory data from patients treated with intravenous artesunate-specifically looking for delayed haemolysis and DAT-was collected., Results: Among the 36 severe malaria patients treated with artesunate at the hospital, 10 (27.8%) developed post-artesunate delayed haemolysis. Out of these, DAT was performed in six, being positive in four of them (at least 40%). DAT was positive only for complement-without IgG-suggesting drug-dependent immune-haemolytic anaemia of the immune-complex type. Three of the four patients were treated with corticosteroids and two also received blood transfusion, with a complete recovery., Conclusions: Drug-induced auto-immune phenomena in post-artesunate delayed haemolysis may be underreported and must be considered. The role of corticosteroids should be reassessed.
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- 2019
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28. Two cases of subcutaneous dirofilariasis in Barcelona, Spain.
- Author
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Laynez-Roldán P, Martínez-de la Puente J, Montalvo T, Mas J, Muñoz J, Figuerola J, and Rodriguez-Valero N
- Subjects
- Adult, Aedes parasitology, Animals, Antiparasitic Agents therapeutic use, Culex parasitology, Disease Transmission, Infectious, Europe, Female, Humans, Ivermectin therapeutic use, Mosquito Vectors parasitology, Spain, Dirofilaria repens isolation & purification, Dirofilariasis diagnosis, Dirofilariasis drug therapy, Dirofilariasis transmission
- Abstract
In recent years, the number of reported cases of human dirofilariasis in Europe has increased and the circulation of Dirofilaria spp. in mosquitoes in several European countries has been proven. We report here two likely autochthonous cases of subcutaneous human dirofilariasis from Barcelona, Spain, caused by Dirofilaria repens. The potential for an increase in human infection is high given the number of cases published recently and the ability of vectors to spread through the Mediterranean basin.
- Published
- 2018
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29. Mobile based surveillance platform for detecting Zika virus among Spanish Delegates attending the Rio de Janeiro Olympic Games.
- Author
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Rodriguez-Valero N, Luengo Oroz M, Cuadrado Sanchez D, Vladimirov A, Espriu M, Vera I, Sanz S, Gonzalez Moreno JL, Muñoz J, and Ledesma Carbayo MJ
- Subjects
- Brazil, Female, Humans, Incidence, Internet, Male, Population Surveillance, Spain, Tropical Medicine, Disease Outbreaks, Travel, Travel-Related Illness, Zika Virus, Zika Virus Infection epidemiology, Zika Virus Infection virology
- Abstract
Background: Zika virus has created a major epidemic in Central and South America, especially in Brazil, during 2015-16. The infection is strongly associated with fetal malformations, mainly microcephaly, and neurological symptoms in adults. During the preparation of the Rio de Janeiro Olympic Games in 2016, members of Olympic Delegations worldwide expressed their concern about the health consequences of being infected with Zika virus. A major risk highlighted by the scientific community was the impact on the spreading of the virus into new territories immediately after the Games., Objectives: To detect real-time incidence of symptoms compatible with arboviral diseases and other tropical imported diseases among the Spanish Olympic Delegation (SOD) attending the Rio Olympic Games in 2016., Methods: We developed a surveillance platform based on a mobile application installed in participant's smartphones that monitored the health status of the SOD through a daily interactive check of the user health status including geo-localization data. The results were evaluated by a study physician on-call through a web-based platform monitoring system. Participants presenting severe symptoms or those compatible with Zika infection prompted an alarm in the system triggering specialized medical assistance and allowing early detection and control of the introduction of arboviral diseases in Spain., Summary of the Results: The system was downloaded by 189 participants and used by 143 of them (76%). Median age was 38 years (IQR 16), and 134 (71%) were male. Mean duration of travel was 19 days (+/-9SD). During the Games the highest accumulated incidence observed was for headache: 6.06% cough: 5.30% and conjunctivitis: 3.03%. The incidence rate of cough during the Olympic Games was 1.1% per day per person, followed by headache 0.8% and 0.4% conjunctivitis or diarrhea. In our cohort we observed that non-athletes experienced more incidence of symptoms, except for incidence of cough which was the same in the two groups (1.1%). No participants reported symptoms fulfilling Zika definition case., Conclusion: Our system did not find cases fulfilling Zika definition amongst participants of the SOD during the Games, consistent with limited cases of Zika in Rio during the Games. The app showed good usability and the web based monitoring platform allowed to manage infectious cases in real-time. The overall system has proven to serve as a real-time surveillance platform for detecting symptoms that could be present in tropical imported diseases, especially arboviral diseases, contributing to the preparedness for the introduction of vector borne-diseases in non-endemic countries., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2018
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30. Imported eosinophilic fever with myositis: A diagnostic challenge.
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Camprubí D, Rodriguez-Valero N, Losada I, Grau-Junyent JM, and Muñoz J
- Subjects
- Adult, Albendazole administration & dosage, Albendazole therapeutic use, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents therapeutic use, Antiprotozoal Agents administration & dosage, Antiprotozoal Agents therapeutic use, Biopsy, Communicable Diseases, Imported epidemiology, Communicable Diseases, Imported parasitology, Diagnosis, Differential, Drinking Water parasitology, Eosinophilia parasitology, Fever parasitology, Humans, L-Lactate Dehydrogenase blood, Malaysia epidemiology, Male, Muscles parasitology, Muscles pathology, Myositis parasitology, Prednisone administration & dosage, Prednisone therapeutic use, Sarcocystosis drug therapy, Sarcocystosis epidemiology, Sarcocystosis parasitology, Spain epidemiology, Splenomegaly, Transaminases blood, Communicable Diseases, Imported diagnosis, Eosinophilia diagnosis, Fever etiology, Myositis diagnosis, Sarcocystosis diagnosis, Travel-Related Illness
- Published
- 2018
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31. Leptospirosis in Spanish travelers returning from Chiang Mai: A case series.
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Rodriguez-Valero N, Moriñigo HM, Martínez MJ, Peiró A, Oliveira I, Bodro M, Gómez-Junyent J, Gascon J, and Muñoz J
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- Adult, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Ceftriaxone administration & dosage, Ceftriaxone therapeutic use, Doxycycline administration & dosage, Doxycycline therapeutic use, Female, Humans, Male, Risk Factors, Thailand epidemiology, Young Adult, Leptospirosis epidemiology, Travel
- Abstract
Background: Leptospirosis is an important zoonosis worldwide, nevertheless is often poor recognized in non tropical settings. In Thailand is becoming an emerging disease and Chiang Mai could become a popular spot to acquire the disease amongst travelers., Methods: We describe three cases of imported leptospirosis undifferentiated fever after travelling to Thailand during the summer of 2015 diagnosed at two Spanish hospitals., Results: Our three patients probably acquired leptospirosis while swimming in freshwater around Chiang Mai, a Thailand's northern region with moderate incidence of leptopirosis. Travelers had normal white blood cell counts and low platelets, suggesting leptospirosis after ruling out other imported diseases such as malaria, dengue or typhoid., Conclusion: As recent findings point out, low platelets and normal white blood cell counts are clinical features that could help the clinician to suspect Leptospirosis infection. It should be always considered as a cause of fever, particularly if travelers come from a tropical country and have had contact with water or flooding, especially during rainy season., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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32. Definitive diagnosis in suspected Middle East Respiratory Syndrome Coronavirus cases.
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Rubio E, Martínez MJ, Gonzalo V, Barrachina J, Torner N, Martínez AI, Jané M, Vilella A, Del Rio A, Rodriguez-Valero N, Pinazo MJ, Muñoz J, Soriano A, Trilla A, Vila J, and Marcos MÁ
- Subjects
- Adult, Aged, Coronavirus Infections diagnosis, Coronavirus Infections diet therapy, Coronavirus Infections virology, Female, Humans, Male, Middle Aged, Middle East ethnology, Middle East Respiratory Syndrome Coronavirus genetics, Polymerase Chain Reaction, Prospective Studies, Spain epidemiology, Young Adult, Coronavirus Infections epidemiology, Middle East Respiratory Syndrome Coronavirus isolation & purification, Travel
- Abstract
We evaluated the microbiological diagnosis in 14 patients with epidemiological and clinical suspicion of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) attended in a non-endemic area between June 2015 and January 2017. While no MERS-CoV was detected, other respiratory viruses were identified in 12 cases and Mycoplasma pneumoniae in 1 case., (© International Society of Travel Medicine, 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2018
- Full Text
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33. Zika Virus Screening among Spanish Team Members After 2016 Rio de Janeiro, Brazil, Olympic Games.
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Rodriguez-Valero N, Borobia AM, Lago M, Sánchez-Seco MP, de Ory F, Vázquez A, Pérez-Arellano JL, Rodríguez CC, Martínez MJ, Capón A, Cañas E, Salas-Coronas J, Galparsoro AA, and Muñoz J
- Subjects
- Anniversaries and Special Events, Athletes, Brazil, Disease Outbreaks prevention & control, Global Health, Humans, Risk Assessment, Spain, Sports, Travel, Zika Virus, Zika Virus Infection epidemiology, Zika Virus Infection virology
- Abstract
We evaluated the risk for the Spanish Olympic Team acquiring Zika virus in Rio de Janeiro, Brazil, during 2016. We recruited 117 team members, and all tested negative for Zika virus. Lack of cases in this cohort supports the minimum risk estimates made before the Games.
- Published
- 2017
- Full Text
- View/download PDF
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