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1. Socioeconomic factors and COVID-19 mortality in immune-mediated rheumatic diseases patients: regional analysis from Argentina, Mexico and Brazil

Author

Martinez-Martinez, Marco Ulises, Isnardi, Carolina Ayelen, Alpizar-Rodriguez, Deshiré, Pons-Estel, Guillermo Javier, Virasoro, Belén María, Alfaro, María Agustina, Petkovic, Ingrid, Quintana, Rosana, Berbotto, Guillermo, Salinas, María Jezabel Haye, Ornella, Sofía, Pera, Mariana, Colunga-Pedraza, Iris Jazmín, Irazoque-Palazuelos, Fedra, Reyes-Cordero, Greta, Rodriguez-Reyna, Tatiana S, Veloz-Aranda, Jose Antonio, Skinner-Taylor, Cassandra Michele, Juárez-Mora, Ingrid Maribel, Silveira, Luis H., Marques, Claudia Diniz Lopes, Xavier, Ricardo Machado, Kakehasi, Adriana Maria, Gomides, Ana Paula, dos Reis-Neto, Edgard Torres, Pileggi, Gecilmara Salviato, Ferreira, Gilda Aparecida, da Mota, Licia Maria Henrique, Pinheiro, Marcelo Medeiros, and Calderaro, Débora Cerqueira

Published
2024
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3. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Castro Coello, Vanessa V, Haye Salinas, María J, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria S, Medina, María A, Savio, Veronica, Rojas Tessel, Romina, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Maria A, Rodriguez Gil, Gustavo F, Risueño, Fabian, Quaglia, Maria I, Scafati, Julia, Cuchiaro, Natalia L, Rebak, Jonathan E, Pineda, Susana I, Calvo, María E, Picco, Eugenia, Yanzi, Josefina G, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta S, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José L, Kisluk, Boris, Castaños Menescardi, Maria S, Gallo, Rosana, Martire, María V, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina S, Aeschlimann, Carolina, Subils, Gisela, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra L, Pinheiro, Marcelo, Ibáñez, Sebastián, Chassin Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešić, Marko, Anić, Branimir, Ćulo, Melanie-Ivana, Pavelić, Tea A, Stranski, Kristina K, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela M, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zazueta Montiel, Beatriz E, Castillo Ortiz, Angel A, Zamora Tehozol, Erick, Vega Morales, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez Reyna, Tatiana S, Rull Gabayet, Marina, Alpízar Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte Gil, Manuel, Nowakowski, Jarosław, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria M, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Mičeková, Dagmar, Capova, Lubica, Macejova, Zelmira, Šteňová, Emőke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Senčarová, Marieta, Žlnayová, Soňa, Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre Rubio, Natalia, Alegre Sancho, Juan J, Corteguera Coro, Montserrat, Cobeta Garcia, Juan C, Torres Martin, Maria C, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd K, Akar, Servet, Icacan, Ozan C, ÇELİK, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline M, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, Todd, Derrick, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio, Karen, Webb Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Ezzati, Fatemeh, Parks, Deborah, Karp, David, Quiceno, Guillermo, Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Lopes Marques, Claudia D, Pileggi, Gecilmara C S, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, and Yazdany, Jinoos

Published
2022
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6. Estrogen‐dependent gene regulation: Molecular basis of TIMP‐1 as a sex‐specific biomarker for acute lung injury.

Author

Almuntashiri, Sultan, Dutta, Saugata, Zhu, Yin, Gamare, Siddhika, Ramírez, Gustavo, Irineo‐Moreno, Valeria, Camarena, Angel, Regino, Nora, Campero, Paloma, Hernández‐Cardenas, Carmen M., Rodriguez‐ Reyna, Tatiana S., Zuñiga, Joaquin, Owen, Caroline A., Wang, Xiaoyun, and Zhang, Duo

Subjects
GENETIC regulation, LENGTH of stay in hospitals, INFLUENZA A virus, H1N1 subtype, INFLUENZA A virus, ESTROGEN receptors, ESTROGEN
Abstract

Increased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of TIMP‐1 and the underlying molecular mechanisms have not been well elucidated. In this study, we found that plasma TIMP‐1 levels were significantly higher in COVID‐19 and H1N1 patients compared with those in healthy subjects (n = 25). TIMP‐1 concentrations were significantly different between males and females in each disease group. Among female but not male patients, TIMP‐1 levels significantly correlated with the PaO2/FiO2 ratio and hospital length of stay. Using the mouse model of ALI induced by the H1N1 virus, we found that TIMP‐1 is strikingly induced in PDGFRα‐positive cells in the murine lungs. Moreover, female mice showed a higher Timp‐1 expression in the lungs on day 3 postinfection. Mechanistically, we observed that estrogen can upregulate TIMP‐1 expression in lung fibroblasts, not epithelial cells. In addition, overexpression of estrogen receptor α (ERα) increased the TIMP‐1 promoter activity. In summary, TIMP‐1 is an estrogen‐responsive gene, and its promoter activity is regulated by ERα. Circulating TIMP‐1 may serve as a sex‐specific marker, reflecting the severity and worst outcomes in female patients with SARS‐CoV2‐ and IAV‐related ALI. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Club Cell Secretory Protein-16 (CC16) as a Prognostic Biomarker for COVID-19 and H1N1 Viral Infections.

Author

Moore, Shane, Gopichandran, Keerthana, Sevier, Elizabeth, Gamare, Siddhika, Almuntashiri, Sultan, Ramírez, Gustavo, Regino, Nora, Jiménez-Alvarez, Luis, Cruz-Lagunas, Alfredo, Rodriguez-Reyna, Tatiana S., Zuñiga, Joaquin, Owen, Caroline A., Wang, Xiaoyun, and Zhang, Duo

Subjects
SARS-CoV-2, APACHE (Disease classification system), ADULT respiratory distress syndrome, VIRUS diseases, LENGTH of stay in hospitals
Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and H1N1 viruses are inflammatory lung pathogens that can lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). ALI/ARDS are still life-threatening diseases in critically ill patients with 30–40% mortality in the last decade. Currently, there are no laboratory tests for the early diagnosis or prognosis of ALI/ARDS. Club cell secretory protein (CC16) has been investigated as a potential biomarker of lung epithelial damage in various lung diseases. In this study, we evaluated whether plasma CC16 reflects the severity of COVID-19 and H1N1 infections. The plasma CC16 levels showed no significant differences between H1N1 and COVID-19 groups (p = 0.09). Among all subjects, CC16 levels were significantly higher in non-survivors than in survivors (p = 0.001). Upon the area under the receiver operating characteristic (AUROC) analysis, CC16 had an acceptable value to distinguish survivors and non-survivors (p = 0.002). In the COVID-19 group, plasma CC16 levels moderately correlated with the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (r = 0.374, p = 0.003) and Sequential Organ Failure Assessment (SOFA) score (r = 0.474, p < 0.001). In the H1N1 group, a positive correlation was observed between the CC16 levels and hospital length of stay (r = 0.311, p = 0.022). Among all the patients, weak correlations between plasma CC16 levels with the SOFA score (r = 0.328, p < 0.001) and hospital length of stay (r = 0.310, p < 0.001) were observed. Thus, circulating CC16 might reflect the severity of COVID-19 and H1N1 infections. [ABSTRACT FROM AUTHOR]

Published
2024
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8. High Mortality of COVID-19 in Young Mexican Patients With Rheumatic Diseases: Comparative Analysis Versus the General Population.

Author

Martínez-Martínez, Marco Ulises, Colunga-Pedraza, Iris Jazmín, Irazoque-Palazuelos, Fedra, Reyes-Cordero, Greta, Rodriguez-Reyna, Tatiana S., Veloz-Aranda, Jose Antonio, Skinner-Taylor, Cassandra Michel, Juárez-Mora, Ingrid Maribel, Silveira, Luis H., Zazueta-Montiel, Beatriz Elena, Castillo-Ortiz, Angel Alejandro, Martínez, Atzintli, Zamora-Tehozol, Erick, Maya-Piña, Lucia Verónica, Perez-Barbosa, Lorena, Galarza-Delgado, Dionicio Angel, Hernandez, Maria Del Carmen, Marquez-Miranda, Oscar, Andrade-Ortega, Lilia, and Fuentes-Hernandez, Mónica N.

Published
2024
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11. Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America

Author

Isnardi, Carolina Ayelen, primary, Alpizar-Rodriguez, Deshire, additional, Calderaro, Débora Cerqueira, additional, Marques, Claudia Diniz Lopes, additional, Pons-Estel, Guillermo Javier, additional, Xavier, Ricardo Machado, additional, Saurit, Verónica, additional, Pisoni, Cecilia Nora, additional, Tissera, Yohana Soledad, additional, D'Angelo Exeni, Maria Eugenia, additional, Alba, Paula, additional, Pereira, Dora, additional, Gobbi, Carla Andrea, additional, Gamba, Maria Julieta, additional, Alfaro, María Agustina, additional, Virasoro, Belén María, additional, Colunga-Pedraza, Iris Jazmín, additional, Irazoque-Palazuelos, Fedra, additional, Reyes-Cordero, Greta, additional, Rodriguez-Reyna, Tatiana S., additional, Veloz-Aranda, Jose Antonio, additional, Skinner-Taylor, Cassandra Michele, additional, Juárez-Mora, Ingrid Maribel, additional, Silveira, Luis H., additional, Pacheco Tena, Cesar Francisco, additional, Xibille-Friedmann, Daniel Xavier, additional, Ferreira, Gilda Aparecida, additional, Kakehasi, Adriana Maria, additional, Pinheiro, Marcelo Medeiros, additional, Gomides, Ana Paula Monteiro, additional, Pileggi, Gecilmara Cristina Salviato, additional, da Mota, Licia Maria Henrique, additional, dos Reis-Neto, Edgard Torres, additional, Ribeiro, Sandra Lúcia Euzébio, additional, de Azevedo Valadares, Lilian David, additional, and Martínez-Martínez, Marco Ulises, additional

Published
2023
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12. Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America.

Author

Ayelen Isnardi, Carolina, Alpizar-Rodriguez, Deshire, Cerqueira Calderaro, Débora, Lopes Marques, Claudia Diniz, Javier Pons-Estel, Guillermo, Machado Xavier, Ricardo, Saurit, Verónica, Nora Pisoni, Cecilia, Soledad Tissera, Yohana, D'Angelo Exeni, Maria Eugenia, Alba, Paula, Pereira, Dora, Andrea Gobbi, Carla, Gamba, Maria Julieta, Alfaro, María Agustina, María Virasoro, Belén, Jazmín Colunga-Pedraza, Iris, Irazoque-Palazuelos, Fedra, Reyes-Cordero, Greta, and Rodriguez-Reyna, Tatiana S.

Published
2024
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14. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Izadi, Zara, primary, Gianfrancesco, Milena A, additional, Schmajuk, Gabriela, additional, Jacobsohn, Lindsay, additional, Katz, Patricia, additional, Rush, Stephanie, additional, Ja, Clairissa, additional, Taylor, Tiffany, additional, Shidara, Kie, additional, Danila, Maria I, additional, Wysham, Katherine D, additional, Strangfeld, Anja, additional, Mateus, Elsa F, additional, Hyrich, Kimme L, additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson-Tovey, Saskia, additional, Kearsley-Fleet, Lianne, additional, Schaefer, Martin, additional, Al-Emadi, Samar, additional, Sparks, Jeffrey A, additional, Hsu, Tiffany Y-T, additional, Patel, Naomi J, additional, Wise, Leanna, additional, Gilbert, Emily, additional, Duarte-García, Alí, additional, Valenzuela-Almada, Maria O, additional, Ugarte-Gil, Manuel F, additional, Ljung, Lotta, additional, Scirè, Carlo A, additional, Carrara, Greta, additional, Hachulla, Eric, additional, Richez, Christophe, additional, Cacoub, Patrice, additional, Thomas, Thierry, additional, Santos, Maria J, additional, Bernardes, Miguel, additional, Hasseli, Rebecca, additional, Regierer, Anne, additional, Schulze-Koops, Hendrik, additional, Müller-Ladner, Ulf, additional, Pons-Estel, Guillermo, additional, Tanten, Romina, additional, Nieto, Romina E, additional, Pisoni, Cecilia N, additional, Tissera, Yohana S, additional, Xavier, Ricardo, additional, Lopes Marques, Claudia D, additional, Pileggi, Gecilmara C S, additional, Robinson, Philip C, additional, Machado, Pedro M, additional, Sirotich, Emily, additional, Liew, Jean W, additional, Hausmann, Jonathan S, additional, Sufka, Paul, additional, Grainger, Rebecca, additional, Bhana, Suleman, additional, Gore-Massy, Monique, additional, Wallace, Zachary S, additional, Yazdany, Jinoos, additional, Dahou, Brahim, additional, Gómez, Gimena, additional, Roberts, Karen, additional, Baez, Roberto M, additional, Castro Coello, Vanessa V, additional, Haye Salinas, María J, additional, Maldonado, Federico N, additional, Reyes, Alvaro A, additional, Alle, Gelsomina, additional, Maldonado Ficco, Hernán, additional, Nieto, Romina, additional, Gobbi, Carla, additional, Tissera, Yohana, additional, Pisoni, Cecilia, additional, Paula, Alba, additional, Albiero, Juan A, additional, Schmid, Maria M, additional, Cosatti, Micaela, additional, Gamba, Maria J, additional, Leandro, Carlevaris, additional, Cusa, María A, additional, German, Noelia, additional, Bellomio, Veronica, additional, Takashima, Lorena, additional, Pera, Mariana, additional, Cogo, Karina, additional, Gálvez Elkin, Maria S, additional, Medina, María A, additional, Savio, Veronica, additional, Rojas Tessel, Romina, additional, Alamino, Rodolfo P, additional, Werner, Marina L, additional, Ornella, Sofía, additional, Casalla, Luciana, additional, de la Vega, Maria, additional, Severina, María, additional, García, Mercedes, additional, Gonzalez Lucero, Luciana, additional, Romeo, Cecilia, additional, Moyano, Sebastián, additional, Barbich, Tatiana, additional, Bertoli, Ana, additional, Baños, Andrea, additional, Petruzzelli, Sandra, additional, Matellan, Carla, additional, Conti, Silvana, additional, Lazaro, Maria A, additional, Rodriguez Gil, Gustavo F, additional, Risueño, Fabian, additional, Quaglia, Maria I, additional, Scafati, Julia, additional, Cuchiaro, Natalia L, additional, Rebak, Jonathan E, additional, Pineda, Susana I, additional, Calvo, María E, additional, Picco, Eugenia, additional, Yanzi, Josefina G, additional, Maid, Pablo, additional, Guaglianone, Debora, additional, Morbiducci, Julieta S, additional, Porta, Sabrina, additional, Herscovich, Natalia, additional, Velasco Zamora, José L, additional, Kisluk, Boris, additional, Castaños Menescardi, Maria S, additional, Gallo, Rosana, additional, Martire, María V, additional, Maldini, Carla, additional, Goizueta, Cecilia, additional, de la Vega Fernandez, Sabrina S, additional, Aeschlimann, Carolina, additional, Subils, Gisela, additional, Rath, Eva, additional, Piette, Yves, additional, Devinck, Mieke, additional, Maeyaert, Bea, additional, Machado Ribeiro, Francinne, additional, Euzebio Ribeiro, Sandra L, additional, Pinheiro, Marcelo, additional, Ibáñez, Sebastián, additional, Chassin Trubert, Anne-Marie, additional, Dong, Lingli, additional, Cajas, Lui, additional, Barešić, Marko, additional, Anić, Branimir, additional, Ćulo, Melanie-Ivana, additional, Pavelić, Tea A, additional, Stranski, Kristina K, additional, Karanovic, Boris, additional, Vencovsky, Jiri, additional, Píchová, Marta, additional, Filkova, Maria, additional, Hamoud, Hesham, additional, Vassilopoulos, Dimitrios, additional, Guzman Melgar, Gabriela M, additional, So, Ho, additional, Király, Márta, additional, Vojdanian, Mahdi, additional, Balbir Gurman, Alexandra, additional, Abutiban, Fatemah, additional, Zepa, Julija, additional, Bulina, Inita, additional, Bukauskiene, Loreta, additional, Zazueta Montiel, Beatriz E, additional, Castillo Ortiz, Angel A, additional, Zamora Tehozol, Erick, additional, Vega Morales, David, additional, Cervántes Rosete, Diana, additional, Martín Nares, Eduardo, additional, Rodriguez Reyna, Tatiana S, additional, Rull Gabayet, Marina, additional, Alpízar Rodríguez, Deshiré, additional, Irazoque, Fedra, additional, Jimenez, Xochitl, additional, Geurts van Bon, Lenny, additional, Zijlstra, Theo, additional, Hoekstra, Monique, additional, Al Adhoubi, Nasra, additional, Salim, Babur, additional, Giraldo, Enrique, additional, Salinas, Ariel, additional, Ugarte Gil, Manuel, additional, Nowakowski, Jarosław, additional, Conway, Richard, additional, Flood, Rachael, additional, McCarthy, Geraldine, additional, Felea, Ioana, additional, Filipescu, Ileana, additional, Rednic, Simona, additional, Groseanu, Laura, additional, Tamas, Maria M, additional, Mlynarikova, Vanda, additional, Skamlova, Martina, additional, Zlnay, Martin, additional, Mičeková, Dagmar, additional, Capova, Lubica, additional, Macejova, Zelmira, additional, Šteňová, Emőke, additional, Raffayova, Helena, additional, Belakova, Gabriela, additional, Strakova, Eva, additional, Senčarová, Marieta, additional, Žlnayová, Soňa, additional, Sabová, Anna, additional, Spisakova, Daniela, additional, Oetterová, Mária, additional, Lukacova, Olga, additional, Bakosova, Martina, additional, Hocevar, Alojzija, additional, de la Torre Rubio, Natalia, additional, Alegre Sancho, Juan J, additional, Corteguera Coro, Montserrat, additional, Cobeta Garcia, Juan C, additional, Torres Martin, Maria C, additional, Campos, Jose, additional, Gomez Puerta, Jose A, additional, Yardimci, Gozd K, additional, Akar, Servet, additional, Icacan, Ozan C, additional, ÇELİK, Selda, additional, Vasylets, Viktoriia, additional, Yeoh, Su-Ann, additional, Vandevelde, Claire, additional, Dunt, Sasha, additional, Leeder, Jane, additional, Macphie, Elizabeth, additional, Salerno, Rosaria, additional, Graver, Christine, additional, Williams, Katie, additional, O'Reilly, Sheila, additional, Devine, Kirsty, additional, Tyler, Jennifer, additional, Warner, Elizabeth, additional, Pilcher, James, additional, Patel, Samir, additional, Nikiphorou, Elena, additional, Chadwick, Laura, additional, Jones, Caroline M, additional, Harrison, Beverley, additional, Thornton, Lucy, additional, O'Kane, Diana, additional, Fusi, Lucia, additional, Low, Audrey, additional, Horton, Sarah, additional, Jatwani, Shraddha, additional, Baig, Sara, additional, Bajwa, Hammad, additional, Berglund, Vernon, additional, Dahle, Angela, additional, Dorman, Walter, additional, Hargrove, Jody, additional, Hilton, Maren, additional, Lebedoff, Nicholas, additional, Leonard, Susan, additional, Morgan, Jennifer, additional, Pfeifer, Emily, additional, Skemp, Archibald, additional, Wilson, Jeffrey, additional, Wolff, Anne, additional, Cepeda, Eduardo, additional, Todd, Derrick, additional, Hare, Denise, additional, Calabrese, Cassandra, additional, Adams, Christopher, additional, Khosroshahi, Arezou, additional, Kilian, Adam, additional, White, Douglas, additional, Winter, Melanie, additional, Fields, Theodore, additional, Siegel, Caroline, additional, Daver, Nicole, additional, Harvey, Melissa, additional, Kramer, Neil, additional, Lamore, Concetta, additional, Hogarty, Suneya, additional, Yeter, Karen, additional, Siddique, Faizah, additional, Ban, Byung, additional, Tanner, Tamar, additional, Ruderman, Eric, additional, Davis, William, additional, Quinet, Robert, additional, Scopelitis, Evangeline, additional, Toribio, Karen, additional, Webb Detiege, Tameka, additional, Zakem, Jerald, additional, Abbass, Khurram, additional, Kepecs, Gilbert, additional, Miranda, Lilliam, additional, Guma, Michael, additional, Haikal, Ammar, additional, Mody, Sushama, additional, Mueller, Daric, additional, Jayatilleke, Arundathi, additional, Zell, JoAnn, additional, Bays, Alison, additional, Dao, Kathryn, additional, Ezzati, Fatemeh, additional, Parks, Deborah, additional, Karp, David, additional, and Quiceno, Guillermo, additional

Published
2022
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16. Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials

Author

Saketkoo, Lesley Ann, Mittoo, Shikha, Huscher, Dörte, Khanna, Dinesh, Dellaripa, Paul F, Distler, Oliver, Flaherty, Kevin R, Frankel, Sid, Oddis, Chester V, Denton, Christopher P, Fischer, Aryeh, Kowal-Bielecka, Otylia M, LeSage, Daphne, Merkel, Peter A, Phillips, Kristine, Pittrow, David, Swigris, Jeffrey, Antoniou, Katerina, Baughman, Robert P, Castelino, Flavia V, Christmann, Romy B, Christopher-Stine, Lisa, Collard, Harold R, Cottin, Vincent, Danoff, Sonye, Highland, Kristin B, Hummers, Laura, Shah, Ami A, Kim, Dong Soon, Lynch, David A, Miller, Frederick W, Proudman, Susanna M, Richeldi, Luca, Ryu, Jay H, Sandorfi, Nora, Sarver, Catherine, Wells, Athol U, Strand, Vibeke, Matteson, Eric L, Brown, Kevin K, Seibold, James R, Aggarwal, Rohit, Ainslie, Gillian, Alkassab, Firas, Allanore, Yannick, Descartes, Paris, Anderson, Marina E, Andonopoulos, Andrew P, Antin-Ozerkis, Danielle, Arrobas, Ana, Ascherman, Dana P, Assassi, Shervin, Baron, Murray, Bathon, Joan M, Behr, Juergen, Beretta, Lorenzo, Bingham, Clifton O, III, Binnie, Matthew, Birring, Surinder S, Boin, Francesco, Bongartz, Tim, Bourdin, Arnaud, Bouros, Demosthenes, Brasington, Richard, Bresser, Paul, Buch, Maya H, Burge, P Sherwood, Carmona, Loreto, Carreira, Patricia E, Carvalho, Carlos RR, Catoggio, Luis J, Chan, Kevin M, Chapman, Jeffrey, Chatterjee, Soumya, Chua, Felix, Chung, Lorinda, Conron, Matthew, Corte, Tamera, Cosgrove, Gregory, Costabel, Ulrich, Cox, Gerard, Crestani, Bruno, Crofford, Leslie J, Csuka, Mary E, Curbelo, Pablo, László, Czirják, Daniil, Zoe, DʼArsigny, Christine L, Davis, Gerald S, de Andrade, Joao A, De Vuyst, Paul, Dempsey, Owen J, Derk, Chris T, Distler, Jörg, Dixon, William G, Downey, Gregory, Doyle, Mittie K, Drent, Marjolein, Durairaj, Lakshmi, Emery, Paul, Espinoza, Luis R, Farge, Dominique, Fathi, Maryam, Fell, Charlene D, Fessler, Barri J, Fitzgerald, John E, Fox, George A, Foeldvari, Ivan, Frech, Tracy M, Freitas, Sara, Furst, Daniel E, Gabrielli, Armando, García-Vicuña, Rosario, Georgiev, Ognian B, Gerbino, Anthony, Gillisen, Adrian, Gladman, Dafna D, Glassberg, Marilyn, Gochuico, Bernadette R, Gogali, Athena, Goh, Nicole S, Goldberg, Avram, Goldberg, Hilary J, Gourley, Mark F, Griffing, Leroy, Grutters, Jan C, Gunnarsson, Ragnar, Hachulla, Eric, Hall, Frances C, Harari, Sergio, Herrick, Ariane L, Herzog, Erica L, Hesselstrand, Roger, Hirani, Nikhil, Hodgson, Ulla, Hollingsworth, Helen M, Homer, Robert J, Hoyles, Rachel K, Hsu, Vivien M, Hubbard, Richard B, Hunzelmann, Nicolas, Isasi, Maria Eloisa, Isasi, Elida Susana, Sergio A Jimenez, Jacobsen Soren, Johnson, Sindhu R, Jones, Christine H, Kahaleh, Bashar, Kairalla, Ronaldo A, Kalluri, Meena, Kalra, Sanjay, Kaner, Robert J, Kinder, Brent W, Klingsberg, Ross C, Kokosi, Maria, RJ Kolb, Martin, Kur-Zalewska, Joanna, Kuwana, Masataka, Lake, Fiona R, Lally, Edward V, Lasky, Joseph A, Laurindo, Ileda M, Able, Lawrence, Lee, Peter, Leonard, Colm T, Lien, Dale C, Limper, Andrew H, Liossis, Stamatis-Nick C, Lohr, Kristine M, Loyd, James E, Lundberg, Ingrid E, Mageto, Yolanda N, Maher, Toby M, Mahmud, Tafazzul H, Manganas, Helene, Marie, Isabelle, Marras, Theodore K, Antônio Baddini Martinez, José, Martinez, Fernando J, Mathieu, Alessandro, Matucci-Cerinic, Marco, Mayes, Maureen D, McKown, Kevin M, Medsger, Thomas A, Jr., Meehan, Richard T, Cristina, Mendes Ana, Meyer, Keith C, Millar, Ann B, Moğulkoç, Nesrin, Molitor, Jerry A, Morais, António, Luc Mouthon, Portugal, Müller, Veronika, Müller-Quernheim, Joachim, Nadashkevich, Oleg, Nador, Roland, Nash, Peter, Nathan, Steven D, Navarro, Carmen, Neves, Sofia, Noth, Imre, Nunes, Hilario, Olson, Amy L., Opitz, Christian F, Padilla, Maria, Pappas, Dimitrios, Parfrey, Helen, Pego-Reigosa, José M, AC Pereira, Carlos, Perez, Rafael, Pope, Janet E, Porter, Joanna C., Renzoni, Elisabeth A, Riemekasten, Gabriela, Riley, David J, Rischmueller, Maureen, Rodriguez-Reyna, Tatiana S, Rojas-Serrano, Romam, Jesse, Rosen, Glenn D, Rossman, Milton, Rothfield, Naomi, Sahn, Steven A, Sanduzzi, Alessandro, Scholand, Mary Beth, Selman, Moises, Senécal, Jean-Luc, Seo, Philip, Silver, Richard M, Solomon, Joshua J, Steen, Virginia, Stevens, Wendy, Strange, Charlie, Sussman, Robert, Sutton, Evelyn D, Sweiss, Nadera J, Tornling, Göran, Tzelepis, George E, Undurraga, Alvaro, Vacca, Allessandra, Vancheri, Carlo, Varga, Janos, Veale, Douglas J, Volkov, Suncica, Walker, Ulrich A, Wencel, Mark, Wesselius, Lewis J, Wickremasinghe, Melissa, Wilcox, Pearce, Wilsher, Margaret L, Wollheim, Frank A, Wuyts, Wim A, Yung, Gordon, Zanon, Pietro, Zappala, Christopher J, Groshong, Steve D, Leslie, Kevin O, Myers, Jeffrey L, Padera, Robert F, R Desai, Sujal, Goldin, Jonathan, Kazerooni, Ella A, Klein, Jeffrey S, Lynch, David A, and Keen, Kevin J

Published
2014
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17. Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19

Author

Iglesias, Martin, primary, Butrón, Patricia, primary, Torre-Villalvazo, Iván, primary, Torre-Anaya, Erik A, primary, Sierra-Madero, Juan, primary, Rodriguez-Andoney, José J, primary, Tovar-Palacio, Armando R, primary, Zentella-Dehesa, Alejandro, primary, Domínguez-Cherit, Guillermo, primary, Rodriguez-Reyna, Tatiana S, primary, Granados-Arriola, Julio, primary, Espisosa-Cruz, Verónica, primary, Téllez-Pallares, Fernando P, primary, Lozada-Estrada, Alexia, primary, Zepeda Carrillo, Carol A, primary, Vázquez-Mézquita, Aldo J, primary, and Nario-Chaidez, Hector F, primary

Published
2021
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18. Agreement Between Physician Evaluation and the Composite Response Index in Diffuse Cutaneous Systemic Sclerosis

Author

Zheng, Boyang, Wang, Mianbo, McKenna, Kerry, Shapiro, Lee, Silver, Richard, Csuka, Mary Ellen, Hoogen, Frank, Robinson, David, Pauling, John D., Hummers, Laura, Krieg, Thomas, Del Galdo, Francesco, Spiera, Robert, Jones, Niall, Khalidi, Nader, Vacca, Alessandra, Vries‐Bouwstra, Jeska K., Gordon, Jessica, Baron, Murray, Pope, Janet E., Hudson, Marie, Gyger, Geneviève, Larché, Maggie J., Masetto, Ariel, Sutton, Evelyn, Rodriguez‐Reyna, Tatiana S., Maltez, Nancy, Smith, Doug, Thorne, Carter, Ikic, Alena, Fortin, Paul R., and Fritzler, Marvin J.

Abstract

Diffuse cutaneous systemic sclerosis (SSc) is a highly heterogeneous disease. A provisionally approved Composite Response Index in diffuse cutaneous SSc (CRISS) was developed as a 1‐year outcome measure for clinical trials. Our goal was to further validate the CRISS by examining agreement between CRISS definitions for improved/non‐improved with physicians' evaluation of disease. Patient profiles from a large observational cohort were created for 50 random diffuse cutaneous SSc patients of <5 years disease duration with improved CRISS scores after 1 year and 50 with non‐improved CRISS scores. Profiles described disease features used during the initial CRISS development at baseline and at 1 year. Each profile was independently rated by 3 expert physicians. Majority opinion determined whether a patient was improved or not improved, and kappa agreement with the CRISS cutoff of 0.6 was calculated. Patients had mean ± SD disease duration of 2.2 ± 1.3 years. There was substantial agreement between the physician majority opinion about each case and the CRISS (κ = 0.76 [95% confidence interval (95% CI) 0.64–0.88]). The agreement between each individual physician opinion and the CRISS was also substantial (κ = 0.70 [95% CI 0.62–0.78]). All CRISS non‐improvers were also rated as non‐improved by physician majority; however, 12 CRISS improvers were rated as non‐improved by physicians. There was substantial agreement between the dichotomous CRISS rating and physician assessment of diffuse cutaneous SSc patients after 1 year. This supports the use of a CRISS cutoff at 0.6 for improvement versus non‐improvement, although the CRISS tended to rate more patients as improved than did physicians.

Published
2022
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19. Characteristics associated with Covid-19 in patients with Rheumatic Disease in Latin America: data from the Covid-19 Global Rheumatology Alliance physician-reported registry

Author

Ugarte-Gil, Manuel F., primary, Marques, Claudia D. L., additional, Alpizar-Rodriguez, Deshire, additional, Pons-Estel, Guillermo J., additional, Xibille-Friedmann, Daniel, additional, Paiva, Eduardo, additional, Zamora-Tehozol, Erick A., additional, Gamboa-Cárdenas, Rocío V., additional, Quintana, Rosana, additional, Rodriguez-Reyna, Tatiana S., additional, Sepúlveda, Ana María, additional, Gianfrancesco, Milena, additional, Evans, Michael, additional, Wallace, Zachary, additional, Sirotich, Emily, additional, Omedo, Evelyn, additional, Hausmann, Jonathan S., additional, Alarcón, Graciela S., additional, Robinson, Philip C., additional, and Yazdany, Jinoos, additional

Published
2020
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21. Immunosuppressive treatment in diffuse cutaneous systemic sclerosis is associated with an improved composite response index (CRISS).

Author

Zheng, Boyang, Hudson, Marie, Wang, Mianbo, Baron, Murray, for the Canadian Scleroderma Research Group, Pope, Janet E., Gyger, Geneviève, Larché, Maggie J., Khalidi, Nader A., Masetto, Ariel, Sutton, Evelyn, Robinson, David, Rodriguez-Reyna, Tatiana S., Maltez, Nancy, Smith, Doug, Thorne, Carter, Ikic, Alena, Fortin, Paul R., and Fritzler, Marvin J.

Published
2020
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22. High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis

Author

Feris, Edmond J., Encinales, Liliana, Awad, Carlos, Stern, Joel N.H., Tabansky, Inna, Jiménez-Alvarez, Luis, Ramírez-Martínez, Gustavo, Cruz-Lagunas, Alfredo, Bobadilla, Karen, Márquez, Eduardo, Granados-Montiel, Julio, Rodriguez-Reyna, Tatiana S., Fernandez-Vina, Marcelo, Granados, Julio, Zuñiga, Joaquin, and Yunis, Edmond J.

Published
2016
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23. Cardiac arrhythmias and conduction defects in systemic sclerosis

Author

Vacca, Alessandra, Meune, Christophe, Gordon, Jessica, Chung, Lorinda, Proudman, Susanna, Assassi, Shervin, Nikpour, Mandana, Rodriguez-Reyna, Tatiana S., Khanna, Dinesh, Lafyatis, Robert, Matucci-Cerinic, Marco, Distler, Oliver, Allanore, Yannick, Vacca, Alessandra, Meune, Christophe, Gordon, Jessica, Chung, Lorinda, Proudman, Susanna, Assassi, Shervin, Nikpour, Mandana, Rodriguez-Reyna, Tatiana S., Khanna, Dinesh, Lafyatis, Robert, Matucci-Cerinic, Marco, Distler, Oliver, and Allanore, Yannick

Abstract

Signs and symptoms of arrhythmias or conduction defects are frequently reported in patients with SSc. These rhythm disorders may have several origins (i.e. related to primary heart involvement, pericardial disease, valvular regurgitation or pulmonary arterial hypertension) and may negatively affect the overall prognosis of these patients. It is therefore important to identify patients at high risk for cardiac arrhythmias with a complete cardiological evaluation and to identify the underlying heart disease, including SSc-related myocardial involvement. In addition, some therapeutic options in SSc patients may differ from those recommended in other populations

Published
2017

24. Calcinosis is associated with digital ischaemia in systemic sclerosis—a longitudinal study

Author

Baron, Murray, primary, Pope, Janet, additional, Robinson, David, additional, Jones, Niall, additional, Khalidi, Nader, additional, Docherty, Peter, additional, Kaminska, Elzbieta, additional, Masetto, Ariel, additional, Sutton, Evelyn, additional, Mathieu, Jean-Pierre, additional, Ligier, Sophie, additional, Grodzicky, Tamara, additional, LeClercq, Sharon, additional, Thorne, Carter, additional, Gyger, Geneviève, additional, Smith, Douglas, additional, Fortin, Paul R., additional, Larché, Maggie, additional, Abu-Hakima, Maysan, additional, Rodriguez-Reyna, Tatiana S., additional, Cabral-Castaneda, Antonio R., additional, Fritzler, Marvin J., additional, Wang, Mianbo, additional, and Hudson, Marie, additional

Published
2016
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25. Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis

Author

Zuñiga, Joaquin, Torres-García, Diana, Santos-Mendoza, Teresa, Rodriguez-Reyna, Tatiana S., Granados, Julio, and Yunis, Edmond J.

Subjects
Article Subject, chemical and pharmacologic phenomena
Abstract

Mycobacterium tuberculosis (Mtb) infection is a major international public health problem. One-third of the world's population is thought to have latent tuberculosis, a condition where individuals are infected by the intracellular bacteria without active disease but are at risk for reactivation, if their immune system fails. Here, we discuss the role of nonspecific inflammatory responses mediated by cytokines and chemokines induced by interaction of innate receptors expressed in macrophages and dendritic cells (DCs). We also review current information regarding the importance of several cytokines including IL-17/IL-23 in the development of protective cellular and antibody-mediated protective responses against Mtb and their influence in containment of the infection. Finally, in this paper, emphasis is placed on the mechanisms of failure of Mtb control, including the immune dysregulation induced by the treatment with biological drugs in different autoimmune diseases. Further functional studies, focused on the mechanisms involved in the early host-Mtb interactions and the interplay between host innate and acquired immunity against Mtb, may be helpful to improve the understanding of protective responses in the lung and in the development of novel therapeutic and prophylactic tools in TB.

Published
2012
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26. HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients

Author

Rodriguez-Reyna, Tatiana S., primary, Mercado-Velázquez, Pamela, additional, Yu, Neng, additional, Alosco, Sharon, additional, Ohashi, Marina, additional, Lebedeva, Tatiana, additional, Cruz-Lagunas, Alfredo, additional, Núñez-Álvarez, Carlos, additional, Cabiedes-Contreras, Javier, additional, Vargas-Alarcón, Gilberto, additional, Granados, Julio, additional, Zúñiga, Joaquin, additional, and Yunis, Edmond, additional

Published
2015
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27. Scleroderma renal crisis: a high index of suspicion speeds diagnosis and life-saving treatment

Author

Medsger, Jr., Thomas A. and Rodriguez-Reyna, Tatiana S.

Subjects
Systemic scleroderma -- Risk factors -- Research, Scleroderma (Disease) -- Risk factors -- Research, Kidney diseases -- Causes of -- Research -- Risk factors, Health, Research, Risk factors, Causes of
Abstract

Scleroderma renal crisis (SRC) is a life-threatening visceral complication of systemic sclerosis (SSc) characterized by the abrupt onset of malignant hypertension and rapidly progressive, oliguric renal failure. Microangiopathic hemolytic anemia [...]

Published
2006

28. Cardiac arrhythmias and conduction defects in systemic sclerosis

Author

Vacca, Alessandra, primary, Meune, Christophe, additional, Gordon, Jessica, additional, Chung, Lorinda, additional, Proudman, Susanna, additional, Assassi, Shervin, additional, Nikpour, Mandana, additional, Rodriguez-Reyna, Tatiana S., additional, Khanna, Dinesh, additional, Lafyatis, Robert, additional, Matucci-Cerinic, Marco, additional, Distler, Oliver, additional, and Allanore, Yannick, additional

Published
2013
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29. Systemic Lupus Erythematosus

Author

Okamoto, Hiroshi, primary, Cervera, Ricard, additional, Rodriguez-Reyna, Tatiana S., additional, Nishimura, Hiroyuki, additional, and Yoshio, Taku, additional

Published
2012
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32. Reconciling Healthcare Professional and Patient Perspectives in the Development of Disease Activity and Response Criteria in Connective Tissue Disease–related Interstitial Lung Diseases

Author

Saketkoo, Lesley Ann, Mittoo, Shikha, Frankel, Sid, LeSage, Daphne, Sarver, Catherine, Phillips, Kristine, Strand, Vibeke, Matteson, Eric L., Baughman, Robert P., Brown, Kevin K., Christmann, Romy B., Dellaripa, Paul, Denton, Christopher P., Distler, Oliver, Fischer, Aryeh, Flaherty, Kevin, Huscher, Dörte, Khanna, Dinesh, Kowal-Bielecka, Otylia, Merkel, Peter A., Oddis, Chester V., Pittrow, David, Sandorfi, Nora, Seibold, James R., Swigris, Jeffrey, Wells, Athol, Antoniou, Katerina, Castelino, Flavia V., Christopher-Stine, Lisa, Collard, Harold R., Cottin, Vincent, Danoff, Sonye, Hedlund, Robert, Highland, Kristin B., Hummers, Laura, Lynch, David A., Kim, Dong Soon, Ryu, Jay H., Christopher-Stine, Lisa, Miller, Frederick W., Nichols, Karen, Proudman, Susanna M., Richeldi, Luca, Shah, Ami A., van den Assum, Pieter, Aggarwal, Rohit, Ainslie, Gillian, Alkassab, Firas, Allanore, Yannick, Anderson, Marina E., Andonopoulos, Andrew P., Antin-Ozerkis, Danielle, Antoniou, Katerina, Arrobas, Ana, Ascherman, Dana P., Assassi, Shervin, Baron, Murray, Bathon, Joan M., Baughman, Robert P., Behr, Juergen, Beretta, Lorenzo, Bingham, Clifton O., Binnie, Matthew, Birring, Surinder S., Boin, Francesco, Bongartz, Tim, Bourdin, Arnaud, Bouros, Demosthenes, Brasington, Richard, Bresser, Paul, Brown, Kevin K., Buch, Maya H., Burge, P. Sherwood, Carmona, Loreto, Castelino, Flavia V., Carreira, Patricia E., Carvalho, Carlos R.R., Catoggio, Luis J., Chan, Kevin M., Chapman, Jeffrey, Chatterjee, Soumya, Christmann, Romy B., Christopher-Stine, Lisa, Chua, Felix, Chung, Lorinda, Conron, Matthew, Corte, Tamera, Cosgrove, Gregory, Costabel, Ulrich, Cottin, Vincent, Cox, Gerard, Crestani, Bruno, Crofford, Leslie J., Csuka, Mary E., Curbelo, Pablo, Czirják, László, Daniil, Zoe, Danoff, Sonye, D’Arsigny, Christine L., Davis, Gerald S., de Andrade, Joao A., Dellaripa, Paul F., De Vuyst, Paul, Dempsey, Owen J., Denton, Christopher P., Derk, Chris T., Distler, Jörg, Distler, Oliver, Dixon, William G., Downey, Gregory, Doyle, Mittie K., Drent, Marjolein, Durairaj, Lakshmi, Emery, Paul, Espinoza, Luis R., Farge, Dominique, Fathi, Maryam, Fell, Charlene D., Fessler, Barri J., Fischer, Aryeh, Fitzgerald, John E., Flaherty, Kevin R., Foeldvari, Ivan, Fox, George A., Frech, Tracy M., Freitas, Sara, Furst, Daniel E., Gabrielli, Armando, García-Vicuña, Rosario, Georgiev, Ognian B., Gerbino, Anthony, Gillisen, Adrian, Gladman, Dafna D., Glassberg, Marilyn, Gochuico, Bernadette R., Gogali, Athena, Goh, Nicole S., Goldberg, Avram, Goldberg, Hilary J., Gourley, Mark F., Griffing, Leroy, Grutters, Jan C., Gunnarsson, Ragnar, Hachulla, Eric, Hall, Frances C., Harari, Sergio, Herrick, Ariane L., Herzog, Erica L., Hesselstrand, Roger, Highland, Kristin, Hirani, Nikhil, Hodgson, Ulla, Hollingsworth, Helen M., Homer, Robert J., Hoyles, Rachel K., Hsu, Vivien M., Hubbard, Richard B., Hummers, Laura, Hunzelmann, Nicolas, Huscher, Dörte, Isasi, Maria Eloisa, Isasi, Elida Susana, Jacobsen, Soren, Jimenez, Sergio A., Johnson, Sindhu R., Jones, Christine H., Kahaleh, Bashar, Kairalla, Ronaldo A., Kalluri, Meena, Kalra, Sanjay, Kaner, Robert J., Khanna, Dinesh, Kim, Dong Soon, Kinder, Brent W., Kiter, Goksel, Klingsberg, Ross C., Kokosi, Maria, Kolb, Martin R.J., Kowal-Bielecka, Otylia M., Kur-Zalewska, Joanna, Kuwana, Masataka, Lake, Fiona R., Lally, Edward V., Lasky, Joseph A., Laurindo, Ileda M., Able, Lawrence, Lee, Peter, Leonard, Colm T., Lien, Dale C., Limper, Andrew H., Liossis, Stamatis-Nick C., Lohr, Kristine M., Loyd, James E., Lundberg, Ingrid E., Mageto, Yolanda N., Maher, Toby M., Mahmud, Tafazzul H., Manganas, Helene, Marie, Isabelle, Marras, Theodore K., Martinez, José Antônio Baddini, Martinez, Fernando J., Mathieu, Alessandro, Matucci-Cerinic, Marco, Mayes, Maureen D., McKown, Kevin M., Medsger, Thomas A., Meehan, Richard T., Mendes, Ana Cristina, Merkel, Peter A., Meyer, Keith C., Millar, Ann B., Miller, Frederick W., Moğulkoç, Nesrin, Molitor, Jerry A., Morais, António, Mouthon, Luc, Müller, Veronika, Müller-Quernheim, Joachim, Nadashkevich, Oleg, Nador, Roland, Nash, Peter, Nathan, Steven D., Navarro, Carmen, Neves, Sofia, Noth, Imre, Nunes, Hilario, Oddis, Chester V., Olson, Amy L., Opitz, Christian F., Padilla, Maria, Pappas, Dimitrios, Parfrey, Helen, Pego-Reigosa, José M., Pereira, Carlos A.C., Perez, Rafael, Phillips, Kristine, Pittrow, David, Pope, Janet E., Porter, Joanna C., Proudman, Susanna M., Renzoni, Elisabeth A., Richeldi, Luca, Riemekasten, Gabriela, Riley, David J., Rischmueller, Maureen, Rodriguez-Reyna, Tatiana S., Rojas-Serrano, J., Roman, Jesse, Rosen, Glenn D., Rossman, Milton, Rothfield, Naomi, Ryu, Jay H., Sahn, Steven A., Sandorfi, Nora, Sanduzzi, Alessandro, Scholand, Mary Beth, Seibold, James R., Selman, Moises, Senécal, Jean-Luc, Seo, Philip, Shah, Ami, Silver, Richard M., Solomon, Joshua J., Steen, Virginia, Stevens, Wendy, Strange, Charlie, Sussman, Robert, Sutton, Evelyn D., Sweiss, Nadera J., Swigris, Jeffrey, Tornling, Göran, Tzelepis, George E., Undurraga, Alvaro, Vacca, Allessandra, Vancheri, Carlo, Varga, Janos, Veale, Douglas J., Volkov, Suncica, Walker, Ulrich A., Wells, Athol U., Wencel, Mark, Wesselius, Lewis J., Wickremasinghe, Melissa, Wilcox, Pearce, Wilsher, Margaret L., Wollheim, Frank A., Wuyts, Wim A., Yung, Gordon, Zanon, Pietro, Zappala, Christopher J., Groshong, Steve D., Leslie, Kevin O., Myers, Jeffrey L., Padera, Robert F., Desai, Sujal R., Goldin, Jonathan, Kazerooni, Ella A., Klein, Jeffrey S., Lynch, David A., and Keen, Kevin J.

Abstract

Interstitial lung diseases (ILD), including those related to connective tissue disease (CTD), and idiopathic pulmonary fibrosis (IPF) carry high morbidity and mortality. Great efforts are under way to develop and investigate meaningful treatments in the context of clinical trials. However, efforts have been challenged by a lack of validated outcome measures and by inconsistent use of measures in clinical trials. Lack of consensus has fragmented effective use of strategies in CTD-ILD and IPF, with a history of resultant difficulties in obtaining agency approval of treatment interventions. Until recently, the patient perspective to determine domains and outcome measures in CTD-ILD and IPF had never been applied. Efforts described here demonstrate unequivocally the value and influence of patient involvement on core set development. Regarding CTD-ILD, this is the first OMERACT working group to directly address a manifestation/comorbidity of a rheumatic disease (ILD) as well as a disease not considered rheumatic (IPF). The OMERACT 11 proceedings of the CTD-ILD Working Group describe the forward and lateral process to include both the medical and patient perspectives in the urgently needed identification of a core set of preliminary domains and outcome measures in CTD-ILD and IPF.

Published
2014
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33. HLA Class I and Class II Conserved Extended Haplotypes and Their Fragments or Blocks in Mexicans: Implications for the Study of Genetic Diversity in Admixed Populations

Author

Zúñiga, Joaquín, Yu, Neng, Barquera, Rodrigo, Alosco, Sharon, Ohashi, Marina, Lebedeva, Tatiana, Acuña-Alonzo, Víctor, Yunis, María, Granados-Montiel, Julio, Cruz-Lagunas, Alfredo, Vargas-Alarcón, Gilberto, Rodríguez-Reyna, Tatiana S., Fernandez-Viña, Marcelo, Granados, Julio, and Yunis, Edmond J.

Abstract

Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA diversity in Mexican admixed individuals. We studied the polymorphism of MHC class I (HLA-A, -B, -C), and class II (HLA-DRB1, -DQB1) genes using high-resolution sequence based typing (SBT) method and we structured the blocks and conserved extended haplotypes (CEHs) in 234 non-related admixed Mexican individuals (468 haplotypes) by a maximum likelihood method. We found that HLA blocks and CEHs are primarily from Amerindian and Caucasian origin, with smaller participation of African and recent Asian ancestry, demonstrating a great diversity of HLA blocks and CEHs in Mexicans from the central area of Mexico. We also analyzed the degree of admixture in this group using short tandem repeats (STRs) and HLA-B that correlated with the frequency of most probable ancestral HLA-C/−B and -DRB1/−DQB1 blocks and CEHs. Our results contribute to the analysis of the diversity and ancestral contribution of HLA class I and HLA class II alleles and haplotypes of Mexican admixed individuals from Mexico City. This work will help as a reference to improve future studies in Mexicans regarding allotransplantation, immune responses and disease associations.

Published
2013
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34. Efficacy and Safety of Tocilizumab for the Treatment of Systemic Sclerosis: Results from a Phase 3 Randomized Controlled Trial

Author

Khanna, Dinesh, Lin, Celia J. F., Kuwana, Masataka, Allanore, Yannick, Batalov, Anastas, Butrimiene, Irena, Carreira, Patricia, Cerinic, Marco Matucci, Distler, Oliver, Kaliterna, Dusanka Martinovic, Mihai, Carina, Mogensen, Mette, Marzena Olesinska, Pope, Janet E., Riemekasten, Gabriela, Rodriguez-Reyna, Tatiana S., Jose Santos, Maria, Laar, Jacob, Spotswood, Helen, Siegel, Jeffrey, Jahreis, Angelika, Furst, Daniel E., and Denton, Christopher P.

Subjects
Systemic sclerosis, tocilizumab and treatment
Abstract

Background/Purpose: The anti–interleukin-6 (IL-6) receptor-alpha antibody tocilizumab (TCZ) demonstrated numeric improvement in skin thickening (modified Rodnan skin score [mRSS]) and clinically meaningful lung function preservation (forced vital capacity [FVC]) in patients with systemic sclerosis (SSc) in a phase 2 randomized controlled trial.1, 2 Efficacy and safety of TCZ vs placebo (PBO) in patients with SSc are now reported from the double-blind period of a phase 3 trial (NCT02453256). Methods: Patients with SSc were randomly assigned 1:1 to receive weekly double-blind injections of subcutaneous TCZ 162 mg or PBO for 48 weeks. Patients could receive escape therapy from week 16 if they experienced declines in FVC or from week 24 if they experienced worsened mRSS or worsened SSc complications. The primary end point was difference in mean change in mRSS from baseline to week 48 for TCZ vs PBO. Key secondary end points were change from baseline in percent predicted FVC at week 48 and time to treatment failure (time from first study treatment to first occurrence of death, decline in FVC >10%, increase in mRSS >20% and mRSS ≥5, or occurrence of predefined SSc-related complications). Results: Among 212 randomly assigned patients, 81% were women ; baseline mean values were age 48 years, SSc duration 23 months, mRSS 20.4, and percent predicted FVC 82.1% (210 patients were treated [PBO, 106 ; TCZ, 104]). At week 48, the primary end point (change in mRSS) was not met but improved numerically (PBO, -4.41 ; TCZ, -6.14 ; adjusted difference in least squares mean, -1.73 [95% CI: -3.78, 0.32] ; p = 0.098) (Figure). Therefore, all other p values were considered nominal. The cumulative distribution of change from baseline to week 48 in percent predicted FVC favored TCZ over PBO (median [IQR]: PBO, -3.9 [-7.2, 0.6] vs TCZ, -0.6 [-5.3, 3.9] ; van Elteren p = 0.0015). The difference in mean change from baseline in FVC at week 48 was 167 mL (95% CI: 83, 250) in favor of TCZ. Preservation of lung function with TCZ was shown by change from baseline in FVC over time (Figure). The hazard ratio (95% CI) for the time to treatment failure end point was 0.63 (0.37, 1.06) in favor of TCZ (Cox proportional hazards model ; p = 0.082). Safety was consistent with known complications of SSc and with the safety profile of TCZ ; serious adverse events were reported by 17% of PBO patients and 13% of TCZ patients ; serious infections were reported by 7% and 2% of patients, respectively.

35. Cardiac arrhythmias and conduction defects in systemic sclerosis

Author

Vacca, Alessandra, Meune, Christophe, Gordon, Jessica, Chung, Lorinda, Proudman, Susanna, Assassi, Shervin, Nikpour, Mandana, Rodriguez-Reyna, Tatiana S., Khanna, Dinesh, Lafyatis, Robert, Matucci-Cerinic, Marco, Distler, Oliver, Allanore, Yannick, Vacca, Alessandra, Meune, Christophe, Gordon, Jessica, Chung, Lorinda, Proudman, Susanna, Assassi, Shervin, Nikpour, Mandana, Rodriguez-Reyna, Tatiana S., Khanna, Dinesh, Lafyatis, Robert, Matucci-Cerinic, Marco, Distler, Oliver, and Allanore, Yannick

Abstract

Signs and symptoms of arrhythmias or conduction defects are frequently reported in patients with SSc. These rhythm disorders may have several origins (i.e. related to primary heart involvement, pericardial disease, valvular regurgitation or pulmonary arterial hypertension) and may negatively affect the overall prognosis of these patients. It is therefore important to identify patients at high risk for cardiac arrhythmias with a complete cardiological evaluation and to identify the underlying heart disease, including SSc-related myocardial involvement. In addition, some therapeutic options in SSc patients may differ from those recommended in other populations

36. High Mortality of COVID-19 in Young Mexican Patients With Rheumatic Diseases: Comparative Analysis Versus the General Population.

Author

Martínez-Martínez MU, Colunga-Pedraza IJ, Irazoque-Palazuelos F, Reyes-Cordero G, Rodriguez-Reyna TS, Veloz-Aranda JA, Skinner-Taylor CM, Juárez-Mora IM, Silveira LH, Zazueta-Montiel BE, Castillo-Ortiz AA, Martínez A, Zamora-Tehozol E, Maya-Piña LV, Perez-Barbosa L, Galarza-Delgado DA, Hernandez MDC, Marquez-Miranda O, Andrade-Ortega L, Fuentes-Hernandez MN, Morales DV, Aguiar MC, Oostdam DAH, Loredo-Alanis SA, Martín-Nares E, Durán-Barragán S, Jiménez-Jiménez X, Vázquez-Del Mercado M, Moctezuma-Rios JF, Rull-Gabayet M, Barragán-Garfías JA, Tena CFP, Xibille-Friedmann DX, and Alpizar-Rodriguez D

Subjects
Humans, Mexico epidemiology, Female, Male, Adult, Young Adult, Middle Aged, Adolescent, COVID-19 mortality, COVID-19 epidemiology, Rheumatic Diseases mortality, Rheumatic Diseases epidemiology, SARS-CoV-2
Published
2024
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37. Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America: Data From Argentina, Mexico, and Brazil.

Author

Isnardi CA, Alpizar-Rodriguez D, Calderaro DC, Marques CDL, Pons-Estel GJ, Xavier RM, Saurit V, Pisoni CN, Tissera YS, D'Angelo Exeni ME, Alba P, Pereira D, Gobbi CA, Gamba MJ, Alfaro MA, Virasoro BM, Colunga-Pedraza IJ, Irazoque-Palazuelos F, Reyes-Cordero G, Rodriguez-Reyna TS, Veloz-Aranda JA, Skinner-Taylor CM, Juárez-Mora IM, Silveira LH, Pacheco Tena CF, Xibille-Friedmann DX, Ferreira GA, Kakehasi AM, Pinheiro MM, Gomides APM, Pileggi GCS, da Mota LMH, Dos Reis-Neto ET, Ribeiro SLE, de Azevedo Valadares LD, and Martínez-Martínez MU

Subjects
Adult, Humans, Male, Female, Middle Aged, SARS-CoV-2, Mexico epidemiology, Latin America, Argentina epidemiology, Brazil epidemiology, Immunomodulating Agents, COVID-19, Rheumatic Diseases epidemiology
Abstract

Objective: To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population., Methods: Data from 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), and ReumaCoV-Brasil (Brazil), were combined. Adult patients with IMIDs and SARS-CoV-2 infection were recruited. Sociodemographic data, comorbidities, IMID clinical characteristics and treatment, and SARS-CoV-2 infection presentation and outcomes were recorded., Results: A total of 4827 individuals were included: 2542 (52.7%) from SAR-COVID, 1167 (24.2%) from CMR-COVID, and 1118 (23.1%) from ReumaCoV-Brasil. Overall, 82.1% were female with a mean age of 49.7 (SD, 14.3) years; 22.7% of the patients were hospitalized, and 5.3% died because of COVID-19 (coronavirus disease 2019). Argentina and Brazil had both 4% of mortality and Mexico 9.4%. In the multivariable analysis, older age (≥60 years; odds ratio [OR], 7.4; 95% confidence interval [CI], 4.6-12.4), male sex (OR, 1.5; 95% CI, 1.1-2.1), living in Mexico (OR, 3.0; 95% CI, 2.0-4.4), comorbidity count (1 comorbidity: OR, 1.5; 95% CI, 1.0-2.1), diagnosis of connective tissue disease or vasculitis (OR, 1.8; 95% CI, 1.3-2.4), and other diseases (OR, 2.6; 95% CI, 1.6-4.1) compared with inflammatory joint disease, high disease activity (OR, 4.2; 95% CI, 2.5-7.0), and treatment with glucocorticoids (OR, 1.9; 95% CI, 1.4-2.5) or rituximab (OR, 4.2; 95% CI, 2.7-6.6) were associated with mortality., Conclusions: Mortality in patients with IMIDs was particularly high in Mexicans. Ethnic, environmental, societal factors, and different COVID-19 mitigation measures adopted have probably influenced these results., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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