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8 results on '"Rodriguez-Hernandez, Guillermo"'

2. Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice

Author

García-Ramírez, Idoia, Tadros, Saber, González-Herrero, Inés, Martín-Lorenzo, Alberto, Rodríguez-Hernández, Guillermo, Moore, Dalia, Ruiz-Roca, Lucía, Blanco, Oscar, Alonso-López, Diego, Rivas, Javier De Las, Hartert, Keenan, Duval, Romain, Klinkebiel, David, Bast, Martin, Vose, Julie, Lunning, Matthew, Fu, Kai, Greiner, Timothy, Rodrigues-Lima, Fernando, Jiménez, Rafael, Criado, Francisco Javier García, Cenador, María Begoña García, Brindle, Paul, Vicente-Dueñas, Carolina, Alizadeh, Ash, Sánchez-García, Isidro, and Green, Michael R.

Published
2017
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4. Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Author

Rodriguez-Hernandez, Guillermo, Opitz, Friederike V., Delgado, Pilar, Walter, Carolin, Alvarez-Prado, Angel F., Gonzalez-Herrero, Ines, Auer, Franziska, Fischer, Ute, Janssen, Stefan, Bartenhagen, Christoph, Raboso-Gallego, Javier, Casado-Garcia, Ana, Orfao, Alberto, Blanco, Oscar, Alonso-Lopez, Diego, De Las Rivas, Javier, Gonzalez de Tena-Davila, Sara, Muschen, Markus, Dugas, Martin, Garcia Criado, Francisco Javier, Garcia Cenador, Maria Begona, Vicente-Duenas, Carolina, Hauer, Julia, Ramiro, Almudena R., Sanchez-Garcia, Isidro, Borkhardt, Arndt, Rodriguez-Hernandez, Guillermo, Opitz, Friederike V., Delgado, Pilar, Walter, Carolin, Alvarez-Prado, Angel F., Gonzalez-Herrero, Ines, Auer, Franziska, Fischer, Ute, Janssen, Stefan, Bartenhagen, Christoph, Raboso-Gallego, Javier, Casado-Garcia, Ana, Orfao, Alberto, Blanco, Oscar, Alonso-Lopez, Diego, De Las Rivas, Javier, Gonzalez de Tena-Davila, Sara, Muschen, Markus, Dugas, Martin, Garcia Criado, Francisco Javier, Garcia Cenador, Maria Begona, Vicente-Duenas, Carolina, Hauer, Julia, Ramiro, Almudena R., Sanchez-Garcia, Isidro, and Borkhardt, Arndt

Abstract

The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection triggers B-ALL development through induction of activation-induced cytidine deaminase (AID; also known as AICDA) in precursor B-cells. This evidence has been largely acquired through the use of ex vivo functional studies. However, whether this mechanism governs native non-transplant B-ALL development is unknown. Here we show that, surprisingly, AID genetic deletion does not affect B-ALL development in Pax5-haploinsufficient mice prone to B-ALL upon natural infection exposure. We next test the effect of premature AID expression from earliest pro-B-cell stages in B-cell transformation. The generation of AID off-target mutagenic activity in precursor B-cells does not promote B-ALL. Likewise, known drivers of human B-ALL are not preferentially targeted by AID. Overall these results suggest that infections promote B-ALL through AID-independent mechanisms, providing evidence for a new model of childhood B-ALL development.

Published
2019

5. CREBBP Loss Cooperates with BCL2 Over-Expression to Promote Lymphoma in Mice

Author

Idoia, García-Ramírez, primary, Shrishrimal, Shashank, additional, Gonzalez-Herrero, Ines, additional, Martín-Lorenzo, Alberto, additional, rodriguez-Hernandez, Guillermo, additional, Duval, Romain, additional, Moore, Dalia, additional, Ruiz-Roca, Lucia, additional, Blanco, Oscar, additional, Alonso-Lopez, Diego, additional, de Las Rivas, Javier, additional, Klinkibiel, David, additional, Bast, Martin, additional, Greiner, Timothy C., additional, Vose, Julie M, additional, Lunning, Matthew, additional, Rodrigues-Lima, Fernando, additional, Jiménez, Rafael, additional, Garcia-criado, Francisco, additional, garcia Cenador, Maria, additional, Brindle, Paul, additional, vicente-Duenas, Carolina, additional, Sánchez-García, Isidro, additional, and Green, Michael R, additional

Published
2016
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6. A New ETV6-RUNX1 In Vivo Model Produces a Phenocopy of the Human Pb-ALL

Author

rodriguez-Hernandez, Guillermo, primary, Hauer, Julia, additional, Martín-Lorenzo, Alberto, additional, Schaefer, Daniel, additional, Bartenhagen, Christoph, additional, Garcia-Ramirez, Idoia, additional, Auer, Franziska, additional, Gonzalez-Herrero, Ines, additional, Ruiz-Roca, Lucia, additional, Okpanyi, Vera, additional, Fischer, Ute, additional, Dugas, Martin, additional, Bhatia, Sanil, additional, Gombert, Michael, additional, Krell, Pina, additional, Chen, Cai, additional, Garcia Suquia, Marta, additional, Rascon Trincado, Maria, additional, Garcia Sanchez, Angel, additional, Blanco, Oscar, additional, garcia Cenador, Maria, additional, Garcia-criado, Francisco, additional, Cobaleda, Cesar, additional, Alonso-Lopez, Diego, additional, de Las Rivas, Javier, additional, vicente-Duenas, Carolina, additional, Sanchez-Gracia, Isidro, additional, and Borkhardt, Arndt, additional

Published
2015
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7. CREBBPLoss Cooperates with BCL2Over-Expression to Promote Lymphoma in Mice

Author

Idoia, García-Ramírez, Shrishrimal, Shashank, Gonzalez-Herrero, Ines, Martín-Lorenzo, Alberto, rodriguez-Hernandez, Guillermo, Duval, Romain, Moore, Dalia, Ruiz-Roca, Lucia, Blanco, Oscar, Alonso-Lopez, Diego, de Las Rivas, Javier, Klinkibiel, David, Bast, Martin, Greiner, Timothy C., Vose, Julie M, Lunning, Matthew, Rodrigues-Lima, Fernando, Jiménez, Rafael, Garcia-criado, Francisco, garcia Cenador, Maria, Brindle, Paul, vicente-Duenas, Carolina, Sánchez-García, Isidro, and Green, Michael R

Abstract

Follicular lymphoma (FL) is genetically characterized by translocations of the BCL2oncogene that are found in ~90% of patients, and mutations of chromatin modifying genes that are found in up to 96% of patients. The latter include inactivating mutations of KMT2Dand CREBBP, and activating mutations of EZH2, among others.

Published
2016
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8. A New ETV6-RUNX1In Vivo Model Produces a Phenocopy of the Human Pb-ALL

Author

rodriguez-Hernandez, Guillermo, Hauer, Julia, Martín-Lorenzo, Alberto, Schaefer, Daniel, Bartenhagen, Christoph, Garcia-Ramirez, Idoia, Auer, Franziska, Gonzalez-Herrero, Ines, Ruiz-Roca, Lucia, Okpanyi, Vera, Fischer, Ute, Dugas, Martin, Bhatia, Sanil, Gombert, Michael, Krell, Pina, Chen, Cai, Garcia Suquia, Marta, Rascon Trincado, Maria, Garcia Sanchez, Angel, Blanco, Oscar, garcia Cenador, Maria, Garcia-criado, Francisco, Cobaleda, Cesar, Alonso-Lopez, Diego, de Las Rivas, Javier, vicente-Duenas, Carolina, Sanchez-Gracia, Isidro, and Borkhardt, Arndt

Abstract

Introduction

Published
2015
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