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1. Young Stellar Object Candidates in IC 417

Author

Rebull, L. M., Anderson III, R. L., Hall, G., Kirkpatrick, J. D., Koenig, X., Odden, C. E., Rodriguez, B., Sanchez, R., Senson, B., Urbanowski, V., Austin, M., Blood, K., Kerman, E., Long, J., and Roosa, N.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

IC 417 is in the Galactic Plane, and likely part of the Aur OB2 association; it is ~2 kpc away. Stock 8 is one of the densest cluster constituents; off of it to the East, there is a 'Nebulous Stream' (NS) that is dramatic in the infrared (IR). We have assembled a list of literature-identified young stellar objects (YSOs), new candidate YSOs from the NS, and new candidate YSOs from IR excesses. We vetted this list via inspection of the images, spectral energy distributions (SEDs), and color-color/color-magnitude diagrams. We placed the 710 surviving YSOs and candidate YSOs in ranked bins, nearly two-thirds of which have more than 20 points defining their SEDs. The lowest-ranked bins include stars that are confused, or likely carbon stars. There are 503 in the higher-ranked bins; half are SED Class III, and $\sim$40\% are SED Class II. Our results agree with the literature in that we find that the NS and Stock 8 are at about the same distance as each other (and as the rest of the YSOs), and that the NS is the youngest region, with Stock 8 a little older. We do not find any evidence for an age spread within the NS, consistent with the idea that the star formation trigger came from the north. We do not find that the other literature-identified clusters here are as young as either the NS or Stock 8; at best they are older than Stock 8, and they may not all be legitimate clusters., Comment: Accepted by AAS Journals

Published
2023
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2. Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Author

Williams TD, Adler T, Smokoff L, Kaur A, Rodriguez B, Prakash KJ, Redzematovic E, Baker TS, Rapoport BI, Yoon ES, Beall DP, Dordick JS, and De Leacy RA

Subjects
osteoporosis, vertebral compression fractures, bone cement, vertebroplasty, kyphoplasty, vertebral augmentation, Medicine (General), R5-920
Abstract

Tyree D Williams,1– 3 Talia Adler,2,4 Lindsey Smokoff,2,4 Anmoldeep Kaur,2,5 Benjamin Rodriguez,2,3,6 Kavita Jyoti Prakash,6 Edib Redzematovic,2 Turner S Baker,2,3,7 Benjamin I Rapoport,2,3 Edward S Yoon,8 Douglas P Beall,9 Jonathan S Dordick,1 Reade A De Leacy3 1Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA; 2Sinai BioDesign, Mount Sinai Medical System, New York, NY, USA; 3Department of Neurosurgery, Mount Sinai Medical System, New York, NY, USA; 4Columbia University School of General Studies, New York, NY, USA; 5Department of Neuroscience, Smith College, Northampton, MA, USA; 6Icahn School of Medicine at Mount Sinai, New York, NY, USA; 7Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 8Hospital for Special Surgery, New York, NY, USA; 9Spine Fracture Institute, Oklahoma City, OK, USACorrespondence: Benjamin Rodriguez, Department of Neurosurgery, Mount Sinai Medical System, One Gustave L. Levy Place, Box 1136, New York, NY, USA, Tel +1 615 524-0211, Email tyree.williams@mssm.eduAbstract: Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside a growing geriatric population. VCFs often result in debilitating back pain and decreased mobility. Cement augmentation, a minimally invasive surgical technique, is widely used to stabilize fractures and restore vertebral height. Acrylic-based cements and calcium phosphate cements are currently the two primary fill materials utilized for these procedures. Despite their effectiveness, acrylic bone cements and calcium phosphate cements have been associated with various intraoperative and postoperative incidents impacting VCF treatment. Over the past decade, discoveries in the field of biomedical engineering and material science have shown advancements toward addressing these limitations. This narrative review aims to assess the potential pitfalls and barriers of the various types of bone cements.Keywords: osteoporosis, vertebral compression fractures, bone cement, vertebroplasty, kyphoplasty, vertebral augmentation

Published
2024

3. Examination of type material of two species of Litomosoides (Filarioidea : Onchocercidae), parasites from bats ; taxonomic consequences

Author

Bain O., Guerrero R., Rodriguez B., Babayan S., and Jouvenet N.

Subjects
filariae, Litomosoides spp., type material, L. hamletti, L.penai, bats, Infectious and parasitic diseases, RC109-216
Abstract

Type material of Litomosoides hamletti Sandground, 1934 from Glossophaga soricina soricina in Brazil and L. penai Jiménez- Quirós & Arroyo, 1 960 from Carollia perspicillata azteca in Costa Rica, was examined. The morphology of the spicules shows that these species belong to the carinii group. Their synonymy with L. guiterasi Pérez Vigueras, 1934, from Artibeus jamaicensis yucatanicus in Cuba, does not appear justified because they are distinct in several characters (body length, width of female, size and shape of buccal cavity and capsule, shape of right spicule). L. hamletti is a valid species; L. penai is closely related to it and is considered to be a sub-species, L. hamletti penai Jiménez-Quirós & Arroyo, 1960: The material recovered from Glossophaga spp., previously assigned to L guiterasi by several authors, is identified as L. h. hamletti. L. guiterasi appears to be closely related to L chandleri Esslinger, 1973; L. chitwoodi n. sp. (= Litomosoides sp. Chitwood, 1938) seems close to these species; all three are parasites of Artibeus spp.

Published
2003
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5. Características clínicas, manejo en urgencias y mortalidad de los episodios de insuficiencia cardiaca aguda en pacientes con enfermedad pulmonar obstructiva crónica

Author

Fuentes, Marta, Dávila, Aitor, del Amo, Sonia, Alonso, Héctor, Pérez-Llantada, Enrique, Martín-Sánchez, Francisco Javier, Miró, Òscar, Gil, Víctor, Escoda, Rosa, Sánchez, Carolina, Repullo, Daniel, Massó, Marta, Millán, Javier, Serrano, Leticia, Pavón, José, González, Nayra Cabrera, Rodríguez, Rafael Calvo, Reyes, Juan Antonio Vega, López-Grima, María Luisa, Valero, Amparo, Juan, María Ángeles, Aguirre, Alfons, Masó, Silvia Mínguez, Pérez, Virginia Fernández-Távora, Mecina, Ana Belén, Tost, Josep, Ramón, Susana Sánchez, Rodríguez, Virginia Carbajosa, Piñera, Pascual, Nicolás, José Andrés Sánchez, Aragüés, Paula Lázaro, Garate, Raquel Torres, Rodríguez, Esther Álvarez, Arias, Pilar Paz, Alquézar-Arbé, Aitor, Herrera, Sergio, Carrete, Carlos José Romero, Jacob, Javier, Roset, Alex, Cabello, Irene, Haro, Antonio, Fuentes, Lidia, Richard, Fernando, Fernández, Elisa, Diez, María Pilar López, Puente, Pablo Herrero, Álvarez, Joaquín Vázquez, García, Belén Prieto, Fernández, Alejandra Fernández, Ramos, Belén Álvarez, Miranda, Natalia Fernández, Llorens, Pere, Espinosa, Begoña, Guzmán, Sergio, Jara, Gema, Felipe, Alba, Gil, Adriana, Andueza, Juan Antonio, Romero, Rodolfo, López, Mariella Luengo, Domínguez, Gema, Ruíz, Martín, Arriaga, Beatriz Amores, Bergua, Beatriz Sierra, Mojarro, Enrique Martín, Jiménez, Lidia Cuevas, Bécquer, Lisette Travería, Burillo, Guillermo, García, Lluís Llauger, Torre, María de los Ángeles González de la, Jiménez, Carmen Esmeralda Romero, Ferrer, Ester Soy, Múñoz, María Adroher, Garrido, José Manuel, Lucas-Imbernón, Francisco Javier, Gaya, Rut, Bibiano, Carlos, Mir, María, Rodríguez, Beatriz, Martín, Monika Vicente, Adrada, Esther Rodríguez, Baldrich, Eva Domingo, Carvajal, Marianela Guzmán, Fortuny, María José, García, Yelenis Gómez, Coronill, Verónica de las Nieves Segura, Esquivias, Marco Antonio, Picón, María del Carmen Martínez, Callejas, Marina Borox, García, Rocío Moyano, Rodríguez, Pablo, Cuevas, María Martínez, Noceda, José, Blasco, Santiago Harris, Romero, Marta, Pedret, Oriol Aguiló, Valladares, Jordi Estopá, González, Natalia Ramos, Lorenzo, Rocio, Valencia, Juan Bautista, Bembibre, Lorena, Guerrero, Inés Fernández, Ivars, N., Llorens, P., Alquézar, A., Jacob, J., Rodríguez, B., Guzmán, M., Serrano Lázaro, L., Martínez Picón, M.C., Cuevas Jiménez, L., and Miró, Ò.

Published
2024
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10. Correlates of psychological intimate partner violence with HIV care outcomes on patients in HIV care

Author

Fredericksen, RJ, Nance, RM, Whitney, BM, Harding, BN, Fitzsimmons, E, Del Rio, C, Eron, J, Feaster, DJ, Kalokhe, AS, Mathews, WC, Mayer, KH, Metsch, LR, Mugavero, MJ, Potter, J, O’Cleirigh, C, Napravnik, S, Rodriguez, B, Ruderman, S, JAC, Delaney, and Crane, HM

Subjects
Epidemiology, Health Services and Systems, Public Health, Health Sciences, HIV/AIDS, Drug Abuse (NIDA only), Violence Against Women, Mental Health, Substance Misuse, Behavioral and Social Science, Clinical Research, Violence Research, Mental health, Peace, Justice and Strong Institutions, Anti-Retroviral Agents, Cross-Sectional Studies, HIV Infections, Humans, Intimate Partner Violence, Prevalence, Sexual Partners, Viral Load, Psychological violence, HIV care, Patient reported outcomes, Public Health and Health Services, Health services and systems, Public health
Abstract

BackgroundAmong people living with HIV (PLWH), physical intimate partner violence (IPV) is associated with poor virologic, psychiatric, and behavioral outcomes. We examined non-physical, psychological intimate partner violence (psy-IPV) and HIV care outcomes using data from two U.S. consortia.MethodsWe conducted multivariable analyses with robust standard errors to compare patients indicating/not indicating psy-IPV.ResultsAmong PLWH (n = 5950), 9.5% indicated psy-IPV; these individuals were younger (- 3; 95% CI [- 2,-4], p-value

Published
2021

13. A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Agudo, P., Amado, C., Arcelus, J.I., Ballaz, A., Bascuñana, J., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Beddar Chaib, F., Botella, E., Cañas, I., Carrero-Arribas, R., Casado, I., Cerdá, P., Chasco, L., Criado, J., de Ancos, C., de Miguel, J., del Toro, J., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Domínguez, I.M., Dubois-Silva, A., Escribano, J.C., Espósito, F., Farfán-Sedano, A.I., Falgá, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García-Bragado, F., García de Herreros, M., Gavín-Blanco, O., Gil-Díaz, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., Gonzalez-Moreno, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lainez-Justo, S., A, Latorre, J, Lima, Jl, Lobo, López-De la Fuente, M., López-Jiménez, L., López-Meseguer, M., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín-Guerra, J.M., Martín-Martos, F., Mellado, M., Mena, E., Moisés, J., Mercado, M.I., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Morales, M.V., Nieto, J.A., Noguera-Gras, E., Núñez-Fernández, M.J., Olid-Velilla, M., Osorio, J., Otalora, S., Otero, R., Paredes-Ruiz, D., Parra, P., Parra, V., Pedrajas, J.M., Pérez-López, M., Peris, M.L., Pesce, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rosa, V., Rodríguez-Cobo, A., Rodríguez-Matute, C., Ruiz-Artacho, P., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suárez-Rodríguez, B., Suriñach, J.M., Tiberio, G., Torres, M.I., Torres-Sánchez, A., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M.M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., El Harake, S., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Dentali, F., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Kigitovica, D., Rusa, E., Skride, A., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Eftimova, A., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Sarlon-Bartoli, Gabrielle, Criado, Juan, Middeldorp, Saskia, Nieto, José Antonio, Díaz-Pedroche, María del Carmen, Moustafa, Farès, Ruiz-Giménez, Nuria, and DI Micco, Pierpaolo

Published
2023
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15. Computational approaches to Explainable Artificial Intelligence: Advances in theory, applications and trends

Author

Górriz, J.M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J.E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S.B., Contreras, R., Cuadra, J.M., Domínguez, E., Domínguez-Mateos, F., Duro, R.J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M.A., Gallego-Molina, N.J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S.C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J.J., Martinez-Murcia, F.J., Martínez-Tomás, R., Mekyska, J., Nalepa, G.J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M.A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P.H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S.H., Wang, W., Zhang, Y.D., Zhu, H., Zhu, Z., and Ferrández-Vicente, J.M.

Published
2023
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18. A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.

Author

Guo, Hou-Fu, Bota-Rabassedas, Neus, Terajima, Masahiko, Leticia Rodriguez, B, Gibbons, Don, Chen, Yulong, Banerjee, Priyam, Tsai, Chi-Lin, Tan, Xiaochao, Liu, Xin, Yu, Jiang, Tokmina-Roszyk, Michal, Stawikowska, Roma, Fields, Gregg, Miller, Mitchell, Wang, Xiaoyan, Lee, Juhoon, Dalby, Kevin, Creighton, Chad, Phillips, George, Tainer, John, Yamauchi, Mitsuo, and Kurie, Jonathan

Subjects
Adenocarcinoma of Lung, Animals, Disease Progression, Glucosyltransferases, Lung Neoplasms, Mice
Abstract

Cancer cells are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen lysyl hydroxylase 2 (LH2) expression promotes metastasis and is correlated with shorter survival in lung adenocarcinoma (LUAD) and other tumor types. LH2 hydroxylates lysine (Lys) residues on fibrillar collagens amino- and carboxy-terminal telopeptides to create stable collagen cross-links. Here, we show that electrostatic interactions between the LH domain active site and collagen determine the unique telopeptidyl lysyl hydroxylase (tLH) activity of LH2. However, CRISPR/Cas-9-mediated inactivation of tLH activity does not fully recapitulate the inhibitory effect of LH2 knock out on LUAD growth and metastasis in mice, suggesting that LH2 drives LUAD progression, in part, through a tLH-independent mechanism. Protein homology modeling and biochemical studies identify an LH2 isoform (LH2b) that has previously undetected collagen galactosylhydroxylysyl glucosyltransferase (GGT) activity determined by a loop that enhances UDP-glucose-binding in the GLT active site and is encoded by alternatively spliced exon 13 A. CRISPR/Cas-9-mediated deletion of exon 13 A sharply reduces the growth and metastasis of LH2b-expressing LUADs in mice. These findings identify a previously unrecognized collagen GGT activity that drives LUAD progression.

Published
2021

19. Brief Report: Weight Gain Following ART Initiation in ART-Naïve People Living With HIV in the Current Treatment Era.

Author

Ruderman, Stephanie A, Crane, Heidi M, Nance, Robin M, Whitney, Bridget M, Harding, Barbara N, Mayer, Kenneth H, Moore, Richard D, Eron, Joseph J, Geng, Elvin, Mathews, William C, Rodriguez, B, Willig, Amanda L, Burkholder, Greer A, Lindström, Sara, Wood, Brian R, Collier, Ann C, Vannappagari, Vani, Henegar, Cassidy, Van Wyk, Jean, Curtis, Lloyd, Saag, Michael S, Kitahata, Mari M, and Delaney, Joseph AC

Subjects
Clinical Research, HIV/AIDS, Clinical Trials and Supportive Activities, Prevention, Infectious Diseases, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Adult, Alanine, Alkynes, Anti-HIV Agents, Anti-Retroviral Agents, Benzoxazines, Cyclopropanes, Dideoxynucleosides, Female, HIV Infections, HIV Integrase Inhibitors, Heterocyclic Compounds, 3-Ring, Humans, Male, Middle Aged, Oxazines, Piperazines, Pyridones, Tenofovir, Weight Gain, HIV, weight, antiretroviral therapy, integrase strand transfer inhibitors, dolutegravir, bictegravir, Clinical Sciences, Public Health and Health Services, Virology
Abstract

ObjectivesEvaluate differences in weight change by regimen among people living with HIV (PLWH) initiating antiretroviral therapy (ART) in the current era.MethodsBetween 2012 and 2019, 3232 ART-naïve PLWH initiated ≥3-drug ART regimens in 8 Centers for AIDS Research Network of Integrated Clinical Systems sites. We estimated weight change by regimen for 11 regimens in the immediate (first 6 months) and extended (all follow-up on initial regimen) periods using linear mixed models adjusted for time on regimen, interaction between time and regimen, age, sex, race/ethnicity, hepatitis B/C coinfection, nadir CD4, smoking, diabetes, antipsychotic medication, and site. We included more recently approved regimens [eg, with tenofovir alafenamide fumarate (TAF)] only in the immediate period analyses to ensure comparable follow-up time.ResultsMean follow-up was 1.9 years on initial ART regimen. In comparison to efavirenz/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC), initiating bictegravir/TAF/FTC {3.9 kg [95% confidence interval (CI): 2.2 to 5.5]} and dolutegravir/TAF/FTC [4.4 kg (95% CI: 2.1 to 6.6)] were associated with the greatest weight gain in the immediate period, followed by darunavir/TDF/FTC [3.7 kg (95% CI: 2.1 to 5.2)] and dolutegravir/TDF/FTC [2.6 kg (95% CI: 1.3 to 3.9)]. In the extended period, compared with efavirenz/TDF/FTC, initiating darunavir/TDF/FTC was associated with a 1.0 kg (95% CI: 0.5 to 1.5) per 6-months greater weight gain, whereas dolutegravir/abacavir/FTC was associated with a 0.6-kg (95% CI: 0.3 to 0.9) and dolutegravir/TDF/FTC was associated with a 0.6-kg (95% CI: 0.1 to 1.1) per 6-months greater gain. Weight gain on dolutegravir/abacavir/FTC and darunavir/TDF/FTC was significantly greater than that for several integrase inhibitor-based regimens.ConclusionsThere is heterogeneity between regimens in weight gain following ART initiation among previously ART-naïve PLWH; we observed greater gain among PLWH taking newer integrase strand transfer inhibitors (DTG, BIC) and DRV-based regimens.

Published
2021

20. Anemia risk factors among people living with HIV across the United States in the current treatment era: a clinical cohort study

Author

Harding, BN, Whitney, BM, Nance, RM, Ruderman, SA, Crane, HM, Burkholder, G, Moore, RD, Mathews, WC, Eron, JJ, Hunt, PW, Volberding, P, Rodriguez, B, Mayer, KH, Saag, MS, Kitahata, MM, Heckbert, SR, and Delaney, JAC

Subjects
Public Health, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Hepatitis, Digestive Diseases, Prevention, HIV/AIDS, Sexually Transmitted Infections, Infectious Diseases, Substance Misuse, Clinical Research, Minority Health, Emerging Infectious Diseases, Liver Disease, Hepatitis - C, Hematology, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aetiology, 2.4 Surveillance and distribution, Infection, Good Health and Well Being, Adult, Anemia, Anti-Retroviral Agents, CD4 Lymphocyte Count, Coinfection, Female, Follow-Up Studies, Glomerular Filtration Rate, HIV, HIV Infections, Hemoglobins, Hepatitis C, Humans, Incidence, Male, Middle Aged, Prospective Studies, Retrospective Studies, Risk Factors, Substance-Related Disorders, United States, Viral Load, Hemoglobin, Cohort, Microbiology, Medical Microbiology, Clinical sciences, Medical microbiology, Public health
Abstract

BackgroundAnemia is common among people living with HIV infection (PLWH) and is associated with adverse health outcomes. Information on risk factors for anemia incidence in the current antiretroviral therapy (ART) era is lacking.MethodsWithin a prospective clinical cohort of adult PLWH receiving care at eight sites across the United States between 1/2010-3/2018, Cox proportional hazards regression analyses were conducted among a) PLWH free of anemia at baseline and b) PLWH free of severe anemia at baseline to determine associations between time-updated patient characteristics and development of anemia (hemoglobin

Published
2020

22. PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma

Author

Tan, Xiaochao, Banerjee, Priyam, Pham, Edward A, Rutaganira, Florentine UN, Basu, Kaustabh, Bota-Rabassedas, Neus, Guo, Hou-Fu, Grzeskowiak, Caitlin L, Liu, Xin, Yu, Jiang, Shi, Lei, Peng, David H, Rodriguez, B Leticia, Zhang, Jiaqi, Zheng, Veronica, Duose, Dzifa Y, Solis, Luisa M, Mino, Barbara, Raso, Maria Gabriela, Behrens, Carmen, Wistuba, Ignacio I, Scott, Kenneth L, Smith, Mark, Nguyen, Khanh, Lam, Grace, Choong, Ingrid, Mazumdar, Abhijit, Hill, Jamal L, Gibbons, Don L, Brown, Powel H, Russell, William K, Shokat, Kevan, Creighton, Chad J, Glenn, Jeffrey S, and Kurie, Jonathan M

Subjects
Lung Cancer, Cancer, Lung, Rare Diseases, Adenocarcinoma of Lung, Animals, Chromosomes, Human, Pair 1, Enzyme-Linked Immunosorbent Assay, Golgi Apparatus, Humans, In Vitro Techniques, Membrane Proteins, Mice, Phosphotransferases (Alcohol Group Acceptor), X-Ray Microtomography, Biological Sciences, Medical and Health Sciences
Abstract

Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet, the molecular underpinnings and therapeutic implications of this feature remain unclear. Here, we identify a chromosome 1q region that is frequently amplified in diverse cancer types and encodes multiple regulators of secretory vesicle biogenesis and trafficking, including the Golgi-dedicated enzyme phosphatidylinositol (PI)-4-kinase IIIβ (PI4KIIIβ). Molecular, biochemical, and cell biological studies show that PI4KIIIβ-derived PI-4-phosphate (PI4P) synthesis enhances secretion and accelerates lung adenocarcinoma progression by activating Golgi phosphoprotein 3 (GOLPH3)-dependent vesicular release from the Golgi. PI4KIIIβ-dependent secreted factors maintain 1q-amplified cancer cell survival and influence prometastatic processes in the tumor microenvironment. Disruption of this functional circuitry in 1q-amplified cancer cells with selective PI4KIIIβ antagonists induces apoptosis and suppresses tumor growth and metastasis. These results support a model in which chromosome 1q amplifications create a dependency on PI4KIIIβ-dependent secretion for cancer cell survival and tumor progression.

Published
2020

25. Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti-PD-1 resistance in non-small cell lung cancer

Author

Konen, Jessica M., Rodriguez, B. Leticia, Wu, Haoyi, Fradette, Jared J., Gibson, Laura, Diao, Lixia, Wang, Jing, Schmidt, Stephanie, Wistuba, Ignacio I., Zhang, Jianjun, and Gibbons, Don L.

Subjects
Drug resistance -- Physiological aspects, Lung cancer, Non-small cell -- Development and progression, Membrane proteins -- Physiological aspects -- Health aspects, Phospholipases -- Physiological aspects -- Health aspects, Health care industry
Abstract

Non-small cell lung cancers that harbor concurrent KRAS and TP53 (KP) mutations are immunologically warm tumors with partial responsiveness to anti-PD-(L)1 blockade; however, most patients observe little or no durable clinical benefit. To identify novel tumor-driven resistance mechanisms, we developed a panel of KP murine lung cancer models with intrinsic resistance to anti-PD-1 and queried differential gene expression between these tumors and anti-PD-1-sensitive tumors. We found that the enzyme autotaxin (ATX), and the metabolite it produces, lysophosphatidic acid (LPA), were significantly upregulated in resistant tumors and that ATX directly modulated antitumor immunity, with its expression negatively correlating with total and effector tumor-infiltrating [CD8.sup.+] T cells. Pharmacological inhibition of ATX, or the downstream receptor LPAR5, in combination with anti-PD-1 was sufficient to restore the antitumor immune response and efficaciously control lung tumor growth in multiple KP tumor models. Additionally, ATX was significantly correlated with inflammatory gene signatures, including a [CD8.sup.+] cytolytic score in multiple lung adenocarcinoma patient data sets, suggesting that an activated tumor-immune microenvironment upregulates ATX and thus provides an opportunity for cotargeting to prevent acquired resistance to anti-PD-1 treatment. These data reveal the ATX/LPA axis as an immunosuppressive pathway that diminishes the immune checkpoint blockade response in lung cancer., Introduction Immune checkpoint blockade (ICB), which targets immunosuppressive axes such as PD-1/PD-L1 via specific antibody treatment, has revolutionized oncological treatment strategies in many cancer types. In particular, non-small cell lung [...]

Published
2023
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26. Local Classical Strategies vs Geometrical Quantum Constraints

Author

Restrepo-Villegas, R., Agudelo, E., Castrillón, J., and Rodríguez, B. A.

Subjects
Quantum Physics
Abstract

We use an alternative approach to show that quantum entanglement-like correlations cannot be reproduced for any classical protocol. In our proposal, quantum geometric restrictions are impose over the physical system related to the existence of entanglement and we demonstrate that there is no classical local strategy that can reproduce them completely. Typically, the implementations of Bell inequalities have as a starting point the expectation of classical behavior and as conclusion the violation due to the quantum character of the system. We go the other way around. For this purpose, we build a computational simulation based on the scheme of non-communicating students. In this scheme, the students cannot manipulate the quantum systems but they may set up in advance a common strategy and share some common classical data in order to try to reproduce the given quantum correlations of such systems. By thoroughly searching in the whole space of classical strategies we conclude that local operations and classical communications does not satisfy the geometrical constraints imposed by quantum entanglement.

Published
2018

27. Multiple-scale analysis of open quantum systems

Author

Bernal-García, D. N., Rodríguez, B. A., and Vinck-Posada, H.

Subjects
Quantum Physics
Abstract

In this work, we present a multiple-scale perturbation technique suitable for the study of open quantum systems, which is easy to implement and in few iterative steps allows us to find excellent approximate solutions. For any time-local quantum master equation, whether markovian or non-markovian, in Lindblad form or not, we give a general procedure to construct analytical approximations to the corresponding dynamical map and, consequently, to the temporal evolution of the density matrix. As a simple illustrative example of the implementation of the method, we study an atom-cavity system described by a dissipative Jaynes-Cummings model. Performing a multiple-scale analysis we obtain approximate analytical expressions for the strong and weak coupling regimes that allow us to identify characteristic time scales in the state of the physical system., Comment: 15 pages, 9 figures

Published
2018
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34. Terahertz spectroscopy of an electron-hole bilayer system in AlN/GaN/AlN quantum wells

Author

Quispe, H. Condori, Islam, S. M., Bader, S., Chanana, A., Lee, K., Chaudhuri, R., Nahata, A., Xing, H. G., Jena, D., and Sensale-Rodriguez, B.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We describe studies on the nanoscale transport dynamics of carriers in strained AlN/GaN/AlN quantum wells: an electron-hole bilayer charge system with large difference in transport properties between the two charge layers. From electronic band diagram analysis, the presence of spatially separated two-dimensional electron and hole charge layers is predicted at opposite interfaces. Since these charge layers exhibit distinct spectral signatures at terahertz frequencies, a combination of terahertz and far-infrared spectroscopy enables us to extract (a) individual contributions to the total conductivity, as well as (b) effective scattering rates for charge-carriers in each layer. Furthermore, by comparing direct-current and terahertz extracted conductivity levels, we are able to determine the extent to which structural defects affect charge transport. Our results evidence that (i) a non-unity Hall-factor and (ii) the considerable contribution of holes to the overall conductivity, lead to a lower apparent mobility in Hall-effect measurements. Overall, our work demonstrates that terahertz spectroscopy is a suitable technique for the study of bilayer charge systems with large differences in transport properties between layers, such as quantum wells in III-Nitride semiconductors., Comment: Applied Physics Letters

Published
2017
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36. Heart Rate and Mortality in Patients With Acute Symptomatic Pulmonary Embolism

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Aibar, J., Aibar, M.A., Alonso, J., Amado, C., Arcelus, J.I., Asuero, A., Azcarate-Agüero, P., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Beddar Chaib, F., Camon, A.M., Castro, J., Chasco, L., Criado, J., de Ancos, C., del Toro, J., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Di Campli, M.V., Dubois-Silva, A., Escribano, J.C., Espósito, F., Farfán-Sedano, A.I., Fernández-Capitán, C., Fernández-Reyes, J.L., Fidalgo, M.A., Flores, K., Font, C., Font, L., Francisco, I., Gabara, C., Galeano-Valle, F., García, M.A., García-Bragado, F., García de Herreros, M., García de la Garza, R., García-Díaz, C., Gil-Díaz, A., Gómez-Cuervo, C., Giménez-Suau, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jiménez-Alfaro, C., Joya, M.D., Lainez-Justo, S., Latorre, A., Lima, J., Lobo, J.L., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Sáez, J.B., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín del Pozo, M., Martín-Martos, F., Martínez-Urbistondo, D., Mella, C., Mercado, M.I., Moisés, J., Monreal, M., Muñoz, M., Muñoz-Blanco, A., Nieto, J.A., Nofuentes-Pérez, E., Núñez-Fernández, M.J., Olid-Velilla, M., Olivares, M.C., Osorio, J., Otalora, S., Otero, R., Pedrajas, J.M., Pellejero, G., Porras, J.A., Portillo, J., Rodríguez-Matute, C., Rosa, V., Ruiz-Artacho, P., Ruiz-Ruiz, J., Salgueiro, G., Sánchez-Martínez, R., Sánchez-Muñoz-Torrero, J.F., Sancho, T., Soler, S., Suárez-Rodríguez, B., Suriñach, J.M., Torres, M.I., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Vidal, G., Villalobos, A., Villares, P., Zamora, C., Ay, C., Nopp, S., Pabinger, I., Vanassche, T., Vandenbriele, C., Verhamme, P., Hirmerova, J., Malý, R., Accassat, S., Ait Abdallah, N., Bertoletti, L., Bura-Riviere, A., Catella, J., Couturaud, F., Crichi, B., Debourdeau, P., Espitia, O., Farge-Bancel, D., Grange, C., Helfer, H., Lacut, K., Le Mao, R., Mahé, I., Morange, P., Moustafa, F., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Quere, I., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Nishimoto, Y., Sato, Y., Birzulis, J., Skride, A., Zaicenko, A., Fonseca, S., Martins, F., Meireles, J., Bosevski, M., Krstevski, G., Bounameaux, H., Mazzolai, L., Bikdeli, B., Caprini, J.A., Bui, H.M., Jaureguízar, Ana, Jiménez, David, Bikdeli, Behnood, Ruiz-Artacho, Pedro, Muriel, Alfonso, Tapson, Victor, López-Reyes, Raquel, Valero, Beatriz, and Kenet, Gili

Published
2022
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38. Standardized regionalization of the atria for 3D cardiac imaging, electroanatomical mapping and computational modeling. A multidisciplinary consensus of the PersonalizeAF consortium

Author

Althoff, T F, primary, Goetz, C, additional, Martinez, L P, additional, Invers-Rubio, E, additional, Hussain, S, additional, Mont, L, additional, Schmidt, C, additional, Corsi, C, additional, Doessel, O, additional, Climent, A M, additional, Rodriguez, B, additional, Schotten, U, additional, Loewe, A, additional, and Guillem, M S, additional

Published
2024
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39. Robot-assisted kidney transplantation: 8-year European experience

Author

Territo, A., primary, Pecoraro, A., additional, Campi, R., additional, Gallioli, A., additional, Basile, G., additional, Gaya, J.M., additional, Etcheverry, B., additional, Musquera, M., additional, Lopez De Mesa Rodriguez, B., additional, Prudhomme, T., additional, Vignolini, G., additional, Volpe, A., additional, Garcia-Baquero, R., additional, Kocak, B., additional, Idu, M., additional, Fornara, P., additional, Rohrsted, M., additional, Doumerc, N., additional, Decaestecker, K., additional, Serni, S., additional, Vigues, F., additional, Alcaraz, A., additional, and Breda, A., additional

Published
2024
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42. Magnetic control of dipolaritons in quantum dots

Author

Rojas-Arias, J. S., Rodríguez, B. A., and Vinck-Posada, H.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Dipolaritons are quasiparticles that arise in coupled quantum wells embedded in a microcavity, they are a superposition of a photon, a direct exciton and an indirect exciton. We propose the existence of dipolaritons in a system of two coupled quantum dots inside a microcavity in direct analogy with the quantum well case and find that, despite some similarities, dipolaritons in quantum dots have different properties and can lead to true dark polariton states. We use a finite system theory to study the effects of the magnetic field on the system, including the emission, and find that it can be used as a control parameter of the properties of excitons and dipolaritons, and the overall magnetic behaviour of the structure., Comment: 7 pages, 8 figures

Published
2016
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46. Real-Time Measurements of Photonic Microchips with Femtometer-Scale Spectral Precision and Ultrahigh Sensitivity

Author

Dashtabi, Mahdi Mozdoor (author), Khoshmehr, Mohammad Talebi (author), Nikbakht, Hamed (author), Lopez Rodriguez, B. (author), Sharma, N. (author), Esmaeil Zadeh, I.Z. (author), Akca, B. Imran (author), Dashtabi, Mahdi Mozdoor (author), Khoshmehr, Mohammad Talebi (author), Nikbakht, Hamed (author), Lopez Rodriguez, B. (author), Sharma, N. (author), Esmaeil Zadeh, I.Z. (author), and Akca, B. Imran (author)

Abstract

Photonic integrated circuits (PICs) are enabling breakthroughs in several areas, including quantum computing, neuromorphic processors, wearable devices, and more. Nevertheless, existing PIC measurement methods lack the spectral precision, speed, and sensitivity required for refining current applications and exploring new frontiers such as point-of-care or wearable biosensors. Here, the “sweeping optical frequency mixing method (SOHO)” is presented, surpassing traditional PIC measurement methods with real-time operation, 30 dB higher sensitivity, and over 100 times better spectral resolution. Leveraging the frequency mixing process with a sweeping laser, SOHO excels in simplicity, eliminating the need for advanced optical components and additional calibration procedures. Its superior performance is demonstrated on ultrahigh-quality factor (Q) fiber-loop resonators (Q = 46 × 106), as well as microresonators, realized on a new optical waveguide platform. An experimental spectral resolution of 19.1 femtometers is demonstrated using an 85-meter-long unbalanced fiber Mach Zehnder Interferometer, constrained by noise resulting from the extended fiber length, while the theoretical resolution is calculated to be 6.2 femtometers, limited by the linewidth of the reference laser. With its excellent performance metrics, SOHO has the potential to become a vital measurement tool in photonics, excelling in high-speed and high-resolution measurements of weak optical signals., ImPhys/Esmaeil Zadeh group

Published
2024
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47. Estudio Te\'orico del espectro de emisi\'on para un sistema microcavidad-punto cu\'antico en una aproximaci\'on de campo medio (Theoretical study of emission spectrum for a quantum dot-microcavity system in a mean field approximation)

Author

Rojas-Arias, Juan S., Rodriguez, B., and Vinck-Posada, Herbert

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

En este trabajo, se obtiene una expresi\'on num\'erica para calcular el espectro de emisi\'on de un sistema microcavidad-punto cu\'antico usando una teor\'ia de campo medio en el formalismo de la matriz densidad. El sistema modelado es un micropilar semiconductor que contiene un \'unico punto cu\'antico en el interior de la microcavidad, este sistema presenta p\'erdida de fotones a trav\'es de los espejos de la cavidad y bombeo de excitones al punto cu\'antico. Obtenemos una ecuaci\'on maestra de campo medio no lineal que nos permite calcular el espectro de emisi\'on. In this work, we deduce a numerical expression to calculate the emission spectrum for a quantum dot-microcavity system, using a mean field theory in the density matrix formalism. The open system modeled, is a typical semiconductor micropillar that contains a single quantum dot inside a microcavity, this system presents leakage of photons through cavity mirrors and pumping of excitons to the quantum dot. We obtain a mean field nonlinear master equation that allow us calculate the emission spectrum., Comment: 10 pages, 4 figures, in Spanish

Published
2015
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