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187 results on '"Rodriguez‐Garcia, Marta"'

4. HIV Research for Prevention 2018: From Research to Impact Conference Summary and Highlights

Author

Shacklett, Barbara L, Blanco, Julià, Hightow-Weidman, Lisa, Mgodi, Nyaradzo, Alcamí, José, Buchbinder, Susan, Chirenje, Mike, Dabee, Smritee, Diallo, Mamadou, Dumchev, Kostyantyn, Herrera, Carolina, Levy, Matthew E, Gayo, Enrique Martin, Makoah, Nigel Aminake, Mitchell, Kate M, Mugwanya, Kenneth, Reddy, Krishnaveni, Rodríguez, Maria Luisa, Rodriguez-Garcia, Marta, Shover, Chelsea L, Shrivastava, Tripti, Tomaras, Georgia, Van Diepen, Michiel, Walia, Monika, Warren, Mitchell, Manrique, Amapola, Thyagarajan, Bargavi, and Torri, Tamara

Subjects
Prevention, HIV/AIDS, Good Health and Well Being, Biomedical Research, Clinical Trials as Topic, HIV Infections, Humans, clinical trial, bNAbs, HIVR4P, immunogens, TasP, Env, Clinical Sciences, Virology
Abstract

The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing HIV prevention research, responding to a growing consensus that effective and durable prevention will require a combination of approaches as well as unprecedented collaboration among scientists, practitioners, and community workers from different fields and geographic areas. The conference theme in 2018, "From Research to Impact," acknowledged an increasing focus on translation of promising research findings into practical, accessible, and affordable HIV prevention options for those who need them worldwide. HIVR4P 2018 was held in Madrid, Spain, on 21-25 October, with >1,400 participants from 52 countries around the globe, representing all aspects of HIV prevention research and implementation. The program included 137 oral and 610 poster presentations. This article presents a brief summary of highlights from the conference. More detailed information, complete abstracts as well as webcasts and daily Rapporteur summaries may be found on the conference website.

Published
2019

7. The challenges of “learning on the go”: A qualitative study of final-year Spanish nursing students incorporated to work during the first Covid-19 pandemic

Author

Velarde-García, Juan Francisco, Cachón-Pérez, Jose Miguel, Rodríguez-García, Marta, Oliva-Fernández, Oscar, González-Sanz, Pilar, Espejo, Marta Mas, González-Hervías, Raquel, Álvarez-Embarba, Beatriz, Moro-López-Menchero, Paloma, Fernández-de-las-Peñas, César, and Palacios-Ceña, Domingo

Published
2021
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9. Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues

Author

Moreno de Lara, Laura, primary, Werner, Alexandra, additional, Borchers, Anna, additional, Carrillo-Salinas, Francisco J., additional, Marmol, Wendelin, additional, Parthasarathy, Siddharth, additional, Iyer, Vidya, additional, Vogell, Alison, additional, Illanes, Diego, additional, Abadía-Molina, Ana C., additional, Ochsenbauer, Christina, additional, Wira, Charles R., additional, and Rodriguez-Garcia, Marta, additional

Published
2023
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15. Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.

Author

de Lara, Laura Moreno, Werner, Alexandra, Borchers, Anna, Carrillo-Salinas, Francisco J., Marmol, Wendelin, Parthasarathy, Siddharth, Iyer, Vidya, Vogell, Alison, Illanes, Diego, Abad´ıa-Molina, Ana C., Ochsenbauer, Christina, Wira, Charles R., and Rodriguez-Garcia, Marta

Subjects
NEUTROPHILS, HIV, GENITALIA, AGING, ANNEXINS
Abstract

Women acquire HIV through sexual transmission, with increasing incidence in women >50 years old. Identifying protective mechanisms in the female genital tract (FGT) is important to prevent HIV-acquisition in women as they age. Human genital and blood neutrophils inactivate HIV by releasing neutrophil extracellular traps (NETs), an innate protective mechanism against HIV-infection. However, how NET formation is triggered by HIV in different tissues and whether this mechanism is affected by aging remain unknown. We demonstrate that the mechanisms that trigger NET release in response to HIV are different in blood and genital tissues, and that NET release decreases with aging. In blood neutrophils, HIV stimulation independently activated calcium pathways and endosomal TLR8, but aging reduced calcium responses, resulting in delayed NET release. In contrast, calcium responses were absent in genital neutrophils and NET release was triggered preferentially through TLR8 activation, but aging impaired this pathway. HIV induced NET formation through non-lytic pathways in blood and FGT neutrophils, except for a small subset of NETs that incorporated annexin V and lactoferrin predominantly in blood, suggesting proinflammatory and lytic NET release. Our findings demonstrate that blood neutrophils cannot model genital neutrophil responses which has important implications to understanding protection against HIV acquisition. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Stimulator of Interferon Genes (STING) regulates Re‐endothelialization Following Vascular Injury

Author

Anastasiou, Marina, primary, Carrillo‐Salinas, Fransisco, additional, Smolgovsky, Sasha, additional, Newton, Gail, additional, Boxerman, Sophia, additional, Moreno De Lara, Laura, additional, Aronovitz, Mark, additional, Kaur, Kuljeet, additional, Rodriguez‐Garcia, Marta, additional, Luscinskas, Francis, additional, and Alcaide, Pilar, additional

Published
2021
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47. Aging impacts CD103+CD8+ T cell presence and induction by dendritic cells in the genital tract.

Author

Rodriguez‐Garcia, Marta, Fortier, Jared M., Barr, Fiona D., and Wira, Charles R.

Subjects
*CELLULAR aging, *CD antigens, *T cells, *GENITALIA, *HYSTERECTOMY, *DENDRITIC cells, *DISEASE susceptibility
Abstract

Summary: As women age, susceptibility to systemic and genital infections increases. Tissue‐resident memory T cells (TRMs) are CD103+CD8+ long‐lived lymphocytes that provide critical mucosal immune protection. Mucosal dendritic cells (DCs) are known to induce CD103 expression on CD8+ T cells. While CD103+CD8+ T cells are found throughout the female reproductive tract (FRT), the extent to which aging impacts their presence and induction by DCs remains unknown. Using hysterectomy tissues, we found that endometrial CD103+CD8+ T cells were increased in postmenopausal compared to premenopausal women. Endometrial DCs from postmenopausal women were significantly more effective at inducing CD103 expression on allogeneic naïve CD8+ T cells than DCs from premenopausal women; CD103 upregulation was mediated through membrane‐bound TGFβ signaling. In contrast, cervical CD103+ T cells and DC numbers declined in postmenopausal women with age. Decreases in DCs correlated with decreased CD103+ T cells in endocervix, but not ectocervix. Our findings demonstrate a previously unrecognized compartmentalization of TRMs in the FRT of postmenopausal women, with loss of TRMs and DCs in the cervix with aging, and increased TRMs and DC induction capacity in the endometrium. These findings are relevant to understanding immune protection in the FRT and to the design of vaccines for women of all ages. [ABSTRACT FROM AUTHOR]

Published
2018
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