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2 results on '"Rodrigues Vde F"'

1. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil.

Author

Rodrigues Vde F, Telles MA, Ribeiro MO, Cafrune PI, Rossetti ML, and Zaha A

Subjects
Microbial Sensitivity Tests, Mycobacterium tuberculosis enzymology, Mycobacterium tuberculosis genetics, Tuberculosis microbiology, Amidohydrolases genetics, Antitubercular Agents pharmacology, Drug Resistance, Bacterial genetics, Mutation, Mycobacterium tuberculosis drug effects, Pyrazinamide pharmacology
Abstract

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

Published
2005
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2. Detection of Mycobacterium avium in blood samples of patients with AIDS by using PCR.

Author

Rodrigues Vde F, Queiroz Mello FC, Ribeiro MO, Fonseca L, Kritski AL, Rossetti ML, and Zaha A

Subjects
Humans, Mycobacterium avium Complex genetics, AIDS-Related Opportunistic Infections microbiology, DNA, Bacterial blood, Mycobacterium avium Complex isolation & purification, Mycobacterium avium-intracellulare Infection microbiology, Polymerase Chain Reaction methods
Abstract

Sixty-nine blood samples from 47 patients infected with human immunodeficiency virus were analyzed by using PCR to detect Mycobacterium avium. The sensitivity can be up to 95.7%, depending on the detection method used and the number of blood samples analyzed from each patient. The procedure can be helpful in the diagnosis of mycobacterial disease.

Published
2002
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