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The inflammatory response to tumors may have positive or negative effects, depending on the histological type and the degree of malignancy. This study aimed to evaluate the predominant inflammatory cells in dog's squamous cell carcinoma, by immunohistochemistry, comparing it with the differentiated tumor (G1) or the not differentiated tumor (G2). About 20 squamous cell carcinoma samples were selected from the archives of the Department of Veterinary Pathology (FCAV-UNESP, Jaboticabal city, estate of São Paulo) and were histologically classified in two groups (G1 = 12/08 = G2) and submitted to the immunohistochemistry technique, to identify macrophages and lymphocytes. The number of lymphocytes was higher in G1. The macrophages predominated in the both groups. Similar to what was described for other tumors in humans, the macrophages function can be inefficient to protect against the tumor. [ABSTRACT FROM AUTHOR]

Many organs are affected by Leishmania, the inflammatory response or by deposition of immune complexes. The objective of this study was to analyze different regions of the skin, lymph nodes, spleen and liver of dogs with visceral leishmaniasis (VL) to determine the parasite load (qPCR) and the proportion of macrophages, lymphocytes and plasma cells (immunohistochemistry). We used 16 symptomatic dogs naturally infected from endemic area for VL and five uninfected dogs. The spleen presented the highest parasite load, followed by of the lymph nodes, skin and liver. In the spleen and lymph nodes the intensity of granulomatous inflammation was more evident than in liver and skin. The infiltrate rich in macrophages and lymphocytes predominated in infected dogs. It was concluded that the parasite could induce an inflammatory response inefficient in controlling infection, especially in the most susceptible organs of dogs with more severe clinical signs. [ABSTRACT FROM AUTHOR]

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