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1. VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.

Author

Sharma, Deepti, Lau, Evan, Qin, Yu, Jee, Kathleen, Rodrigues, Murilo, Guo, Chuanyu, Dinabandhu, Aumreetam, McIntyre, Emma, Salman, Shaima, Hwang, Yousang, Moshiri, Ala, Semenza, Gregg, Montaner, Silvia, and Sodhi, Akrit

Subjects
age-related macular degeneration, angiopoietin-like 4, choroidal neovascularization, hypoxia inducible factor, vascular endothelial growth factor, Animals, Humans, Receptors, Vascular Endothelial Growth Factor, Angiopoietin-Like Protein 4, Retinal Pigment Epithelium, Vascular Endothelial Growth Factor A, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Recombinant Fusion Proteins, Choroidal Neovascularization, Wet Macular Degeneration, Angiogenesis Inhibitors, Gene Expression Regulation, Male, Female
Abstract

Neovascular age-related macular degeneration (nvAMD) is the leading cause of severe vision loss in the elderly in the developed world. While the introduction of therapies targeting vascular endothelial growth factor (VEGF) has provided the first opportunity to significantly improve vision in patients with nvAMD, many patients respond inadequately to current anti-VEGF therapies. It was recently demonstrated that expression of a second angiogenic mediator, angiopoietin-like 4 (ANGPTL4), synergizes with VEGF to promote choroidal neovascularization (CNV) in mice and correlates with reduced response to anti-VEGF therapy in patients with nvAMD. Here, we report that expression of ANGPTL4 in patients with nvAMD increases following treatment with anti-VEGF therapy and that this increase is dependent on accumulation of hypoxia-inducible factor (HIF)-1α in response to inhibition of VEGF/KDR signaling in the retinal pigment epithelium (RPE). We therefore explored HIF-1 inhibition with 32-134D, a recently developed pharmacologic HIF-inhibitor, for the treatment of nvAMD. 32-134D prevented the expression of both VEGF and ANGPTL4 and was at least as effective as aflibercept in treating CNV in mice. Moreover, by preventing the increase in HIF-1α accumulation in the RPE in response to anti-VEGF therapy, combining 32-134D with aflibercept was more effective than either drug alone for the treatment of CNV. Collectively, these results help explain why many patients with nvAMD respond inadequately to anti-VEGF therapy and suggest that the HIF inhibitor 32-134D will be an effective drug-alone or in combination with current anti-VEGF therapies-for the treatment of patients with this blinding disease.

Published
2024

2. Copper-Based Nanomaterials for Biologically Relevant Compounds

Author

dos Santos Batista, Jorge Gabriel, primary, Vigilato Rodrigues, Murilo Álison, additional, de Freitas, Lucas Freitas, additional, Moreira Fonseca, Ana Carolina, additional, de Souza Rodrigues, Adriana, additional, Cunha da Cruz, Cássia Priscila, additional, Thipe, Velaphi Clement, additional, and Lugão, Ademar Benévolo, additional

Published
2024
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5. Impacts of intake of trichothecenes (Fusarium sporotrichioides) for dairy calves: Effects on animal growth, oxidative and inflammatory response

Author

Machado, Marcela, Nora, Luisa, Zanin, Tayse Burger Neto, Bissacotti, Bianca F., Morsch, Vera M., Vedovatto, Marcelo, Pelisser, Giovana, Mendes, Ricardo E., Galvão, Alessandro C., Speroni, Caroline Sefrin, Gloria, Eduardo M., Rodrigues, Murilo F., Wagner, Roger, Stefani, Lenita M., and da Silva, Aleksandro S.

Published
2024
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9. Rheology of nanoscale polymer-based coatings

Author

Bertolo, Mirella Romanelli Vicente, primary, Rodrigues, Murilo Álison Vigilato, additional, Horn, Marilia Marta, additional, de Oliveira Filho, Josemar Gonçalves, additional, Marangon, Crisiane Aparecida, additional, Ferreira, Marcos David, additional, de Guzzi Plepis, Ana Maria, additional, and Bogusz, Stanislau, additional

Published
2023
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10. List of contributors

Author

Akhtaruzzaman, Md., primary, Albayrak, Sevda, additional, Al-Thani, Noora, additional, Arifur Rahim, Md., additional, Aruna, S.T., additional, Ashkar, Rana, additional, Barshilia, Harish C., additional, B C, Bhadrapriya, additional, Bera, Parthasarathi, additional, Bertolo, Mirella Romanelli Vicente, additional, Beryl J, Raja, additional, Bhadra, Jolly, additional, Bhattacharya, Shantanu, additional, Binder, Kurt, additional, Bogusz, Stanislau, additional, Bose, Bosely Anne, additional, C, Dhanalakshmi, additional, Centurion, Franco, additional, Chen, Hui, additional, de Guzzi Plepis, Ana Maria, additional, de Oliveira Filho, Josemar Gonçalves, additional, E.K., Radhakrishnan, additional, Ferreira, Marcos David, additional, Fischlschweiger, Michael, additional, Ganguly, Sayan, additional, George, Jesiya Susan, additional, Goswami, Amit, additional, Gül, Canser, additional, He, Xiaoling, additional, Horn, Marilia Marta, additional, Huang, Haowei, additional, Jain, Shilpa, additional, Joseph, Blessy, additional, Kalarikkal, Nandakumar, additional, Karuppasamy, K., additional, Kollu, Pratap, additional, Lakshmi, R.V., additional, Lal, Hiran Mayookh, additional, Liang, Wei, additional, Ma, Yanqi, additional, Mameda, Naresh, additional, Manickam, Sukumar, additional, Manoharan, Kapil, additional, Marangon, Crisiane Aparecida, additional, Margel, Shlomo, additional, Mathew, Feba Ann, additional, McGranaghan, Gerard, additional, Mettu, Srinivas, additional, Milchev, Andrey, additional, Nair, Radhakrishnan, additional, Pallickal Babu, Sujith, additional, Pandey, Mohit, additional, Parangusan, Hemalatha, additional, Patra, Niranjan, additional, Patra, Swapnita, additional, Pillai, Suresh C., additional, Ponnamma, Deepalekshmi, additional, P R, Suraj, additional, Rahmaninejad, Hadi, additional, Rodrigues, Jolina, additional, Rodrigues, Murilo Álison Vigilato, additional, Romo-Uribe, Angel, additional, Salerno, Marco, additional, Sam, Samanta, additional, Sheng, Xinxin, additional, Shimpi, Navinchandra G., additional, Shukla, Malvika, additional, Shuvankar Purohit, Shuvendu, additional, S.P, Vinodhini, additional, Sundari C, Shanmuga, additional, Swain, Sarat K., additional, Thomas, Sabu, additional, Tian, Yuqin, additional, Uthaman, Arya, additional, Veeramalai, Chandrasekar Perumal, additional, Vijayan P, Poornima, additional, Wang, Bing, additional, Wang, Weishan, additional, Xavier, Joseph Raj, additional, Zeiner, Tim, additional, Zhang, Li, additional, Zhang, Xinya, additional, Zhao, Chenmin, additional, and Zhong, Shuncong, additional

Published
2023
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18. Advances in silver nanoparticles: a comprehensive review on their potential as antimicrobial agents and their mechanisms of action elucidated by proteomics.

Author

Rodrigues, Adriana S., Batista, Jorge G. S., Rodrigues, Murilo Á. V., Thipe, Velaphi C., Minarini, Luciene A. R., Lopes, Patricia S., and Lugão, Ademar B.

Subjects
BACTERIAL cell membranes, MEMBRANE proteins, SILVER nanoparticles, PROTEIN expression, DAUGHTER ions
Abstract

Nanoparticles play a crucial role in the field of nanotechnology, offering different properties due to their surface area attributed to their small size. Among them, silver nanoparticles (AgNPs) have attracted significant attention due to their antimicrobial properties, with applications that date back from ancient medicinal practices to contemporary commercial products containing ions or silver nanoparticles. AgNPs possess broad-spectrum biocidal potential against bacteria, fungi, viruses, and Mycobacterium, in addition to exhibiting synergistic effects when combined with certain antibiotics. The mechanisms underlying its antimicrobial action include the generation of oxygen-reactive species, damage to DNA, rupture of bacterial cell membranes and inhibition of protein synthesis. Recent studies have highlighted the effectiveness of AgNPs against various clinically relevant bacterial strains through their potential to combat antibioticresistant pathogens. This review investigates the proteomic mechanisms by which AgNPs exert their antimicrobial effects, with a special focus on their activity against planktonic bacteria and in biofilms. Furthermore, it discusses the biomedical applications of AgNPs and their potential non-preparation of antibiotic formulations, also addressing the issue of resistance to antibiotics. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Trauma e Emergência - Teoria e Prática

Author

Macedo, Alice Freitas, primary, Mugayar, Amanda Amorim, additional, Souza, Ana Carolina Azevedo, additional, Ribeiro, Ana Sofia Sousa, additional, Oliveira, Beatriz Carvalho de, additional, Barbosa, Bernardo Brandão, additional, Costa, Caio Pluvier Duarte, additional, Nunes, Carol Baby, additional, Massahud, Felipe Corrêa, additional, Maximiano, Marianna Letícia de B., additional, Luvizotto, Pedro Henrique de M., additional, Braga, Samuel Vitorio, additional, Mello, Thiago Souza de, additional, Barros, Fernando de, additional, Silva, Antônio Augusto de Melo da, additional, Silva, Angel Adriany da, additional, Zvicker, Aliana Lunardi, additional, Rocha, Anne Karoline Cardozo da, additional, Thomé, Carolina Weibel, additional, Santos, Maiara Raíssa dos, additional, Ando, Paula Kaori, additional, Marconi, Victor Toniolo, additional, Becker, Karin Aparecida, additional, Bahten, Luiz Carlos Von, additional, Paviato, Arthur Barata, additional, Oliveira, Bianca Nascimento, additional, Colares, Carlos Augusto Chaves, additional, Mandacaru, Gabriel Plazzi, additional, Soares, Julia Florenzano, additional, Souza, Larissa Mendes de, additional, Lotfi, Luana de Oliveira, additional, Soares, Luisa Faria Guimaraes, additional, Lima, André Ferreira de, additional, Santos, Emiliano Miguel Esteves dos, additional, Reis, Claudio Kalume, additional, Santos, Miriam Vitória Rodrigues dos, additional, Brancalhoni, Victoria Almeida, additional, Macêdo, Ângela Caroline Dias Albino Destro de, additional, Zica, Maria Clara Rocha, additional, Borges, Danielle Silva, additional, Souza, Gabriela Medeiros de, additional, Dotto, Raisa Natalia, additional, Almeida, Bruna Auta Damasceno de, additional, Barreto, Larissa Maia Lemos, additional, Pereira, Raissa Lohayne, additional, Rosário, Isabelle Souza do, additional, Gomes, Laura Vitória Melo, additional, Borges, Geovana Martins, additional, Martins, Letícia Ribeiro de Souza, additional, Silva, Victória Cândido da, additional, Maia, Ludmila Ferrante Silveira, additional, Pereira, Gabriela Saldes Campos, additional, Morais, Fernanda Ferreira de, additional, Liam, Renata de Paula, additional, Magueta Filho, Vistam Luiz, additional, Oliveira, Filipe Altino de, additional, Brito Filho, Marcos Torres de, additional, Marques, Sarah Souza, additional, Gonçalves, Hélder Santos, additional, Pereira, Matheus Martins, additional, Santos, José Abimael da Silva, additional, Matos, Ana Caroline Gusmão de, additional, Jesus, Carla Viviane Freitas de, additional, Leal, Roberta Kayane Silva, additional, Santana, Monique Lordelo da Silva de, additional, Mesquita Junior, Renato Morais de Almeida, additional, Ferreira, Alessandro Santos, additional, Fonseca, Mateus Rodrigues, additional, Macedo, Marcos Miranda, additional, Fontinha, Paulo Roberto Bastos, additional, Campos, Felipe Monnerat, additional, Ferreira, Victor Simões, additional, Custódio Junior, Demar, additional, Menezes, Flavio Tarcilo Ribeiro, additional, Kneipp, Angélica Freitas da Silva, additional, Siqueira, Orlando Hiroshi Kiono, additional, Vilhena, Pedro Parenti do Couto, additional, BAPTISTELLA, GABRIEL, additional, MENDONÇA, LUCAS, additional, LOMONACO, ANA CLARA C., additional, SOUZA, JÚLIA TRONE VENTURA, additional, GUIMARÃES, LAÍS LEAL, additional, SCHIAVONI, LARA CABRAL, additional, MIYASHIRO, LETICIA MIDORI MURAMATSU, additional, Ortega, Mirthes Monteiro, additional, Ortega, Gabriela Monteiro, additional, Mattos, Antônio Ferreira Louzada de, additional, Fraga, Daniele da Rosa, additional, Nadais, Giovana Lopes, additional, Robertson, Giovane Lourenço, additional, Brandão, Natália Lima de Sousa, additional, Almeida, Raphael Pizzatto Raposo, additional, Faria, Rebeca Borél Calado, additional, Pires, Thatiana da Silva, additional, Osanan, Gabriel Costa, additional, Rodrigues, Daisy Martins, additional, Gonçalves, Ana Luiza Oliveira Aranda, additional, Pereira, Gabriel Ruzza De Avila, additional, Monteiro, Giovana Bastos, additional, Silveira, João Vitor Flores, additional, Pinheiro, Letícia De Oliveira, additional, Oliveira, Romildo Rodrigues De, additional, Fukuti, Yohana Teodoro Costa, additional, Ambrosio, Marcos Flavio Spinola, additional, Barbosa, Ana Luiza Leal, additional, Cunha, Deise Lima, additional, Padrão, Lara Helena Lemos Fuzari, additional, Cypriano, Rafael Vago, additional, Cançado, Renata Pittella, additional, Neves, Gabriela Carneiro, additional, Arantes, Bernardo de Castro Borges, additional, Baesso, Isadora Bitencourt, additional, Jardim, Lucas Santos, additional, Naves, Maria Eduarda Ferreira, additional, Araujo, Marcos Soares, additional, Valadares, Pedro Augusto Rosa, additional, Freire, Tiago Quelotti, additional, Diniz, Cláudio Galuppo, additional, Dias, Vanessa Cordeiro, additional, Silva, Vânia Lúcia da, additional, Machado, Alessandra Barbosa Ferreira, additional, Chagas, Étore Goulart, additional, Costa, Vitor Cardoso, additional, Borges, Guilherme Henrique, additional, Costa, Marcelo Dias Moreira de Assis, additional, Paranhos, Luiz Renato, additional, Mendes, Mayara Madeira, additional, Azevedo, Gustavo Paiva, additional, Amaral, Débora Toledo, additional, Silva, João Inácio Migliorini, additional, Alarcon, Mariane de Araújo Messias, additional, Vasconcelos, Sócrates Christian Faria de, additional, Gazzinelli, Mariana, additional, SILVA, Patrícia de Cássia Neri Beraldo, additional, Araújo, Milena Barbosa De, additional, Lacerda, Gustavo Frade, additional, Lopes, Ana Carolina Araújo Barbosa, additional, Rocha, Edson Siqueira Da, additional, Barreto, Isabella Siqueira, additional, Denizar, João Gabriel Medina, additional, Teixeira, Larissa Ribeiro, additional, Abreu, Lucas Coelho De, additional, Fernandes, Mariana Macedo, additional, Paiva, Paula Costa Vieira, additional, Ferreira, Paula Souza, additional, Oliveira, Paulo Vitor Kelmon Silva de, additional, Piva, Carolina Ticianeli, additional, Oliveira, Lucas Santos de, additional, Pires, Carlos Henrique Nunes, additional, Ibiapina, Ana Clara Monteiro, additional, Santos, Ana Cristina Araújo dos, additional, Soares, Alícia Rebeca Silva, additional, Silva, Gabriel Oliveira da, additional, Romero, Lia Raquel Lustosa Costa, additional, Alves, Loenne da Silva Santos, additional, Teixeira, Natalia Da Silva, additional, Passos, Ester da Silva Sousa, additional, Louzeiro, Karolaine Rodrigues, additional, Silva, Jordeilson Luis Araújo, additional, Zanetti, Bernardo Valle, additional, Ordono, Bianca Alves Mira, additional, Andrade, Daniel Camargo de, additional, Souza, Jéssica Castro Mattos de, additional, Borges, Matheus Salgado Guedes, additional, Figueira, Matheus Teperino Percegoni, additional, Paschoalino, Miguel Guimarães da Silva, additional, Dutra, Milla Giancristofaro, additional, Buettel, Ricardo Poubel, additional, Fernandes, Vitor Hugo Lobo, additional, Gomes, Marina Marques Novais, additional, SANTANA, BÁRBARA REIS DE, additional, Valois, Gabriel Morais, additional, Souza, Júllia Beatriz Araujo, additional, Prado, Lídia Ruth Oliveira, additional, Souza, Luana Thaynar Correia de, additional, Araújo, Sabrina Layra Souza, additional, Matos, Cássia Cristina Ferreira, additional, Alves, Carolina Pantuzzo Leão, additional, Prado, Ingrid Silva, additional, Martins, Isabela de Souza Freitas, additional, Lara, Marcela Luíza Amaral Resende, additional, Magalhães, Mariana Mortimer, additional, Buzzi, Mayraline de Castilho, additional, Gysegem, Sophie Barreto Van, additional, Lima, Yvnna Santos, additional, Vieira, Arthur Sobral, additional, Andrade, Gabrielle Barbosa Lima de, additional, Souza, Gabrielle Barbosa Vasconcelos de, additional, Rodrigues, Isabella Moreira Saraiva, additional, Dantas, Lucas Gomes, additional, Souza, Mylenna Bomfim, additional, Almeida, Maria Bernadete Galrão de, additional, Macedo, Alice Freitas, additional, Souza, Ana Carolina de Azevedo, additional, Nunes, Caroline Baby, additional, Maximiano, Mariana Letícia de Bastos, additional, Luvizotto, Pedro Henrique de Morais, additional, Baltar, Valéria Trancoso, additional, Oliveira, Paulo Henrique Tavares de, additional, Damasco, Paula Hesselberg, additional, Guaraná, Thais, additional, Ferraro, Matheus Cruz, additional, Flores, Pedro Henrique Cordeiro, additional, Martins, Otávio Cosendey, additional, Cruz Filho, José Emiliano, additional, Ribas, Igor Magaton, additional, Gomes, João Pedro Medeiros, additional, Fernandes, Isabelle de Fatima, additional, Rodrigues, Murilo Oliveira, additional, Santos, Robbert Brunelly, additional, Athayde, Victor Hugo Ferrante Maia, additional, Araujo, Isabela Ayres de, additional, Rodrigues, Larissa Caroline, additional, Lima, Luísa Canedo, additional, Ribeiro, Luiz Gustavo Mesquita, additional, Macedo, Maria Luísa Miranda, additional, Pires, Matheus Rodrigues, additional, Gama, Rafael Muniz, additional, Silva Filho, Wilson Ferreira da, additional, Andrade, Isadora Riberio da Costa, additional, Castro, Nelissa Abud de, additional, Pereira, Larissa Royer, additional, Aguiar, Nathalia Marra, additional, Teixeira, Letícia Fernandes, additional, Araújo, Blenda Maria Soares de, additional, Paranhos, Rafaela Moreira, additional, Abreu, Gabriel Ramos de, additional, Santana, Dayane Campos, additional, Andrade, Marianny Rodrigues de, additional, Gonçalves, Bianca Aparecida, additional, Fonseca, Giulio Gori, additional, Figueiredo, Gabriel Augusto de Souza, additional, Abreu, Gustavo Ramos de, additional, Freire, Vinícius Benatti, additional, Silva, Ana Cristina Simões e, additional, Souza, Lucas Cressoni de, additional, Martinelli, Mário Henrique de Lima, additional, Romano, João Vicente Tadeo Russo, additional, Sacchi, Leonardo Moysés, additional, Souza, Thales Andolfo de, additional, Damin, Antonio Eduardo, additional, Miranda, Lorena Araújo, additional, ROCHA, LAURA COELHO PIRES, additional, Fontana, Luiza Lubiana, additional, Mafra, Sofia Cunha, additional, Cruvinel, Amanda Reis, additional, Azevedo, Gabriela Figueira Caetano, additional, Rocha, Luiza Mara Vieira, additional, Ferreira, Maria Luiza Ludermir, additional, Camilo, Mariana Prates, additional, Moreira, Mariana Luiza, additional, Nassur, Stella Fernandes, additional, Aride, Ana Clara Savignon, additional, Brant, Lara Azevedo Prais Caldeira, additional, França, Marina Cotta, additional, Benazet, Luiz Fernando, additional, Oliveira, Alexandre Ribeiro de, additional, Sasaki, Caroline Suemi, additional, Yoshikawa, Catherine Alexia, additional, Fernandes, Fernanda Magalhães, additional, Uehara, Gabriela Mayumi, additional, Gonçales, Isabela de Alencar, additional, Magalhães, Karen Araújo, additional, Canavarros, Lara Azambuja, additional, Barbosa, Layala Stefane de Paula, additional, Gondim, Luiz Fellyppe Nunes, additional, Ribeiro, Nathaly Castro, additional, Fiorante, Rafael Bavaresco, additional, Salomé, Túlio Máximo, additional, Trichez, Virginia Demarchi Kappel, additional, Oliveira, Alexandre Chaves Jubé, additional, Brommonschenkel, Alexandre De Castro, additional, Freitas, Ana Cristina Dias, additional, Guerra, Carine Marina Dias, additional, Tolentino, Daiany Rodrigues, additional, Pereira, Felipe Magno Alves, additional, Amaral, Felipe Augusto Aparecido, additional, Vale, Gabriela Cecília Araújo, additional, Jesus, Lara Souza Pêgo de, additional, Moreira, Letícia Isabella de Souza, additional, Melo, Marina Viana, additional, Viana, Paulo Maurício Campos, additional, Rocha, Rafaela Rossi, additional, Dias, Samuel Filippe Motta Martins, additional, Arantes, Vinícius Mendes Carvalho, additional, Souza, Lorrany Cristina Silva de, additional, Soares, Diuliana Marina, additional, Puppim, Pedro Henrique Bastos, additional, Silva, Iago José Cunha, additional, Batista, Luna Brenda Carvalho Abade Moura, additional, Campolina, Gabriela Arbex, additional, Ribeiro, Déborah Maria Gonçales, additional, Fernandes, Fernanda Pimenta, additional, Elias, Gabriela Couto, additional, Freitas, Hanna Luísa de Oliveira, additional, Rabello, Laura Nacife, additional, Silva, Matheus Andrade Almeida e, additional, Fonseca, Bia Yamashita, additional, Souza, Ana Elisa de Freitas, additional, Silva, Isabela Marques, additional, Rodrigues, Maria Eduarda Santos, additional, Lopes, Carla Carolina Alves, additional, Silva, Camila Rocha Cunha, additional, Gonçalves, Cláudia Maria de Souza, additional, Salles, Júlia de Souza, additional, Barbosa, Paullinne Ariel Nogueira, additional, Novais, Rommel Lacher Rachid, additional, Cezillo, Marcus Vinicius Boaretto, additional, Heitor, Frederico de Almeida, additional, Cardoso, Nivaldo de Moraes, additional, Oliveira, Carlos Reinaldo de, additional, Silva, David Henrique Ferreira da, additional, Oliveira, Eduarda Gomes de, additional, Silva, Giovanna Favaro da, additional, Azevedo, Mariana de Souza, additional, Silva, Julia Vilafranca Soares da, additional, Dipe, Thiago Lima, additional, Coutinho, Laura Acevedo, additional, Coutinho, Laura Azevedo, additional, Galdino, Roberto, additional, Almeida, Bruna Damasceno de, additional, Maguetas Filho, Wistan Luiz, additional, Maiolini, Mariana Gazzinelli, additional, Maximiano, Marianna Letícia de Bastos, additional, Andrade, Isadora Ribeiro da Costa, additional, Gama, Rafael Munniz, additional, Rabelo, Rodrigo Guimarães, additional, Dias, Maria Luiza Patrão, additional, Cotta, Marina França, additional, Fiorante, Rafael Bravaresco, additional, Freitas, Ana Cristina Dias de, additional, Amaral, Felipe Augusto Aparecido do, additional, and Aguiar, Alessandra N de, additional

Published
2021
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24. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Author

Feng, Xiaodong, Degese, Maria, Iglesias-Bartolome, Ramiro, Vaque, Jose, Molinolo, Alfredo, Rodrigues, Murilo, Zaidi, M, Ksander, Bruce, Merlino, Glenn, Sodhi, Akrit, Chen, Qianming, and Gutkind, J

Subjects
Animals, Cell Cycle Proteins, Cell Growth Processes, Cell Line, Tumor, Female, GTP Phosphohydrolases, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Knockdown Techniques, HEK293 Cells, Heterografts, Hippo Signaling Pathway, Humans, Melanoma, Mice, Mice, Inbred NOD, Mutation, Nuclear Proteins, Protein Serine-Threonine Kinases, Signal Transduction, Skin Neoplasms, Transcription Factors, Transfection, Uveal Neoplasms, rho GTP-Binding Proteins, Melanoma, Cutaneous Malignant
Abstract

Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric Gαq family members, have been identified in ∼ 83% and ∼ 6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional coactivator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that Gαq stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of phospholipase Cβ and the canonical Hippo pathway. Furthermore, we show that Gαq promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, a GNAQ/GNA11-initiated human malignancy.

Published
2014

26. Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration

Author

Babapoor-Farrokhran, Savalan, primary, Qin, Yu, additional, Flores-Bellver, Miguel, additional, Niu, Yueqi, additional, Bhutto, Imran A., additional, Aparicio-Domingo, Silvia, additional, Guo, Chuanyu, additional, Rodrigues, Murilo, additional, Domashevich, Timothy, additional, Deshpande, Monika, additional, Megarity, Haley, additional, Chopde, Rakesh, additional, Eberhart, Charles G., additional, Canto-Soler, Valeria, additional, Montaner, Silvia, additional, and Sodhi, Akrit, additional

Published
2023
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29. EVOLUÇÃO DA MORTALIDADE POR SIDA NO BRASIL: ENFOQUE NA REGIÃO AMAZÔNICA

Author

Baia, Vitor Ferreira, primary, Bentes, Natália Henriques Menezes, additional, Pelaes, Larissa Andrade, additional, Rodrigues, Murilo da Silva, additional, Oliveira, Maria Clara Neres Iunes de, additional, Azevedo, Walber Henrique Cunha, additional, Silva, Maria Clara Pinheiro da, additional, and Oliveira, João Victor Farias de, additional

Published
2020
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31. OPTIMAL CONTROLLERS FOR THE OPERATION OF ACTIVATED SLUDGE TREATMENT SYSTEMS.

Author

Tosta dos Reis, José Antonio, Brazzali Rodrigues, Murilo, Ferreira Mendonça, Antônio Sérgio, Braga da Silva, Fernando das Graças, and Dias Lara, Lorena Lemos

Subjects
CONTROL theory (Engineering), OPTIMAL control theory, ORGANIC compounds, ACTIVATED sludge process, WATER pollution, BIOMASS, PARTICULATE matter, TRANSBOUNDARY waters, WASTEWATER treatment
Abstract

Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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34. Estimative of reference flows for water resources planning and control: hydrologic regional indicators application

Author

Piol , Matheus Siqueira, Reis, José Antonio Tosta dos, Rodrigues , Murilo Brazzali, Mendonça , Antônio Sergio Ferreira, Silva, Fernando das Graças Braga da, Silva, Alex Takeo Yasumura Lima, Piol , Matheus Siqueira, Reis, José Antonio Tosta dos, Rodrigues , Murilo Brazzali, Mendonça , Antônio Sergio Ferreira, Silva, Fernando das Graças Braga da, and Silva, Alex Takeo Yasumura Lima

Abstract

Due to limitations of hydrometeorological monitoring network related to spatial station distribution and extension of historical series, tools that aim to improve consistency and optimize available data analysis have become essential. In this context, regionalization techniques stand out, once the main focus is the delimitation of hydrologically homogeneous regions with the subsequent spatial transposition of hydrological variables of interest. Regional indicators, defined as the mean values of hydrological variables and characteristics of a homogeneous region, constitute an expeditious approach to hydrological regionalization. The main perspective of the study was to evaluate the use of regional indicators when quantifying reference flows associated with average flow, drought, or flood conditions. The study area selected was the Manhuaçu River basin, a major Doce River tributary, located in the state of Minas Gerais, Brazil. The results showed that the regional indicators allow estimates of diverse reference flows with mean errors lower than 30%, considered satisfactory for the study area. However, the conventional method of flow regionalization presented more consistent results, with mean errors usually lower than 20%, regardless of the reference flow analyzed. It was also observed that adopting historical flow series with varied extensions did not produce relevant differences when appropriating the diverse reference flows for the Manhuaçu River basin, with none exceeding 3%., Em função das limitações da rede de monitoramento hidrometeorológico, tanto do ponto de vista da distribuição espacial quanto da extensão das séries históricas, ferramentas que busquem dar consistência e otimizar a análises dos dados disponíveis vêm ganhando espaço. Neste contexto, destacam-se as técnicas de regionalização, cujo principal foco é a delimitação de regiões hidrologicamente homogêneas com a subsequente transposição espacial de variáveis hidrológicas de interesse. Os indicadores regionais, definidos como valores médios de uma variável hidrológica e característicos de uma região homogênea, constituem abordagem expedita de regionalização hidrológica. O presente estudo teve como principal perspectiva avaliar o emprego de indicadores regionais quando da quantificação de vazões de referência associadas às condições médias de escoamento, estiagens ou cheias. A área de estudo selecionada para a condução do estudo foi a bacia hidrográfica do rio Manhuaçu, importante afluente do rio Doce, Minas Gerais, Brasil. Os resultados demonstraram que os indicadores regionais permitem estimativas de diferentes vazões de referências com erros médios inferiores a 30%, considerados satisfatórios para a área de estudo. No entanto, o método convencional de regionalização de vazões apresentou resultados mais consistentes, com erros médios usualmente inferiores a 20%, independentemente da vazão de referência analisada. Observou-se, adicionalmente, que a adoção de séries históricas de vazões com diferentes extensões não produziu diferenças relevantes quando da apropriação das diferentes vazões de referência para a bacia hidrográfica do rio Manhuaçu, com diferenças que não superaram 3%.

Published
2023

35. HIF-1[alpha] and HIF-2[alpha] redundantly promote retinal neovascularization in patients with ischemic retinal disease

Author

Zhang, Jing, Qin, Yaowu, Martinez, Mireya, Flores-Bellver, Miguel, Rodrigues, Murilo, Dinabandhu, Aumreetam, Cao, Xuan, Deshpande, Monika, Qin, Yu, Aparicio-Domingo, Silvia, Rui, Yuan, Tzeng, Stephany Y., Salman, Shaima, Yuan, Jin, Scott, Adrienne W., Green, Jordan J., Canto-Soler, M. Valeria, Semenza, Gregg L., Montaner, Silvia, and Sodhi, Akrit

Subjects
Sickle cell anemia -- Complications and side effects -- Drug therapy, Neovascularization -- Genetic aspects -- Health aspects, Retinal diseases -- Development and progression -- Drug therapy, Transcription factors -- Health aspects, Health care industry
Abstract

Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes that promote retinal neovascularization (NV) to the transcription factors that regulate their expression. We demonstrated increased expression of HIF-1[alpha] and HIF-2[alpha] in the ischemic inner retina of PSR eyes. Although both HIFs participated in promoting VEGF expression by hypoxic retinal Muller cells, HIF-1 alone was sufficient to promote retinal NV in mice, suggesting that therapies targeting only HIF-2 would not be adequate to prevent PSR. Nonetheless, administration of a HIF-2-specific inhibitor currently in clinical trials (PT2385) inhibited NV in the oxygen-induced retinopathy (OIR) mouse model. To unravel these discordant observations, we examined the expression of HIFs in OIR mice and demonstrated rapid but transient accumulation of HIF-1[alpha] but delayed and sustained accumulation of HIF- 2[alpha]; simultaneous expression of HIF-1[alpha] and HIF-2[alpha] was not observed. Staggered HIF expression was corroborated in hypoxic adult mouse retinal explants but not in human retinal organoids, suggesting that this phenomenon may be unique to mice. Using pharmacological inhibition or an in vivo nanoparticle-mediated RNAi approach, we demonstrated that inhibiting either HIF was effective for preventing NV in OIR mice. Collectively, these results explain why inhibition of either HIF-1[alpha] or HIF-2[alpha] is equally effective for preventing retinal NV in mice but suggest that therapies targeting both HIFs will be necessary to prevent NV in patients with PSR., Introduction Several multicenter randomized controlled clinical trials have demonstrated the benefit of monthly (or bimonthly) injections with biological molecules directed against the vasoactive mediator VEGF to treat macular edema in [...]

Published
2021
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36. Modified impression technique for extreme mouthopening limitation caused by systemic scleroderma.

Author

de Arruda Paes-Junior, Tarcisio José, Nomura Nakano, Leonardo Jiro, Rivoli Rossi, Natalia, Rocha Rodrigues, Murilo, Watanabe, Helena, and Mayumi Inagati, Cristiane

Subjects
DENTAL impressions, MOUTH abnormalities, REMOVABLE partial dentures, SYSTEMIC scleroderma, DENTAL impression materials
Abstract

Systemic scleroderma is a relatively rare, autoimmune, chronic, and debilitating disease, and its etiology is unknown. The disease is characterized by vasomotor disturbances causing skin and mucosa hardening, hand stiffness, excess production of collagen fibers, and impairment of the internal organs associated with the immune system. Extreme mouth-opening limitation is one of the symptoms in the oral cavity, and compromises dental intervention. One of the fundamental steps when performing a dental procedure is dental arch impression. In the presented clinical case, limited mouth opening hindered the impression accuracy. The objective was to present an alternative impression technique for a patient affected by scleroderma, with limited mouth opening and the need for oral rehabilitation with a removable partial prosthesis in the maxillary arch. An individualized tray was developed with design characteristics that allowed access to the oral cavity and removal, after which it was possible to perform the oral impression, reproducing the areas of interest without causing injury to the oral tissues. The orientation plan was elaborated after obtaining the cast. The teeth were assembled, tested in the mouth, and sent to the laboratory for acrylization. The prosthesis was placed once ready. The alternative impression technique enabled oral rehabilitation of the patient despite the mouth-opening limitation, and provided an accurate impression and a good prosthetic result. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Robotic approach to remove four tailgut cyst cases in Brazil: a case series

Author

Bulisani, Bruno Mirandola, primary, Gomes, Luiz Guilherme Lisboa, additional, Leite, Milena Arruda de Oliveira, additional, Moreno, Ricardo, additional, Rodrigues, Murilo Rocha, additional, Rossi, Felipe Martin Bianco, additional, Silva, Renato Barretto Ferreira da, additional, Carmo, Luiz Carlos Benjamin do, additional, and Waisberg, Jaques, additional

Published
2023
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47. Influence of Optional Crystallization Firing on the Adhesion of Zirconia-Reinforced Lithium Silicate before and after Aging

Author

Rodrigues, Murilo Rocha, primary, Grangeiro, Manassés Tercio Vieira, additional, Rossi, Natalia Rivoli, additional, de Carvalho Ramos, Nathalia, additional, de Carvalho, Rodrigo Furtado, additional, Kimpara, Estevão Tomomitsu, additional, Tribst, João Paulo Mendes, additional, and de Arruda Paes Junior, Tarcisio José, additional

Published
2022
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