21 results on '"Rodrigues, Moreno M."'
Search Results
2. Impact of Xpert MTB/RIF implementation in tuberculosis case detection and control in Brazil: a nationwide intervention time-series analysis (2011–2022)
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Villalva-Serra, Klauss, Barreto-Duarte, Beatriz, Miguez-Pinto, João P., Queiroz, Artur T.L., Rodrigues, Moreno M., Rebeiro, Peter F., Amorim, Gustavo, Cordeiro-Santos, Marcelo, Sterling, Timothy R., Araújo-Pereira, Mariana, and Andrade, Bruno B.
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- 2024
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3. Retreatment and Anti-tuberculosis Therapy Outcomes in Brazil Between 2015 and 2022: A Nationwide Study.
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Barreto-Duarte, Beatriz, Villalva-Serra, Klauss, Miguez-Pinto, João P, Araújo-Pereira, Mariana, Campos, Vanessa M S, Rosier, Gabriela, Nogueira, Betânia M F, Queiroz, Artur T L, Rolla, Valeria C, Cordeiro-Santos, Marcelo, Kritski, Afrânio L, Martinez, Leonardo, Rebeiro, Peter F, Sterling, Timothy R, Rodrigues, Moreno M, and Andrade, Bruno B
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PATIENT compliance ,TREATMENT effectiveness ,ODDS ratio ,REGRESSION analysis ,TUBERCULOSIS ,DIRECTLY observed therapy - Abstract
Background Adherence to anti-tuberculosis treatment (ATT) in Brazil remains a challenge in achieving the goals set by the World Health Organization (WHO). Patients who are lost to follow-up during treatment pose a significant public health problem. This study aimed to investigate the factors associated with unfavorable ATT outcomes among those undergoing retreatment in Brazil. Methods We conducted an observational study of patients aged ≥18 years with tuberculosis (TB) reported to the Brazilian National Notifiable Disease Information System between 2015 and 2022. Clinical and epidemiologic variables were compared between the study groups (new cases and retreatment). Regression models identified variables associated with unfavorable outcomes. Results Among 743 823 reported TB cases in the study period, 555 632 cases were eligible, consisting of 462 061 new cases and 93 571 undergoing retreatments (44 642 recurrent and 48 929 retreatments after loss to follow-up [RLTFU]). RLTFU (odds ratio [OR], 3.96 [95% confidence interval {CI}, 3.83–4.1]) was a significant risk factor for any type of unfavorable ATT. Furthermore, RLTFU (OR, 4.93 [95% CI, 4.76–5.11]) was the main risk factor for subsequent LTFU. For death, aside from advanced age, living with HIV (OR, 6.28 [95% CI, 6.03–6.54]) was the top risk factor. Conclusions Retreatment is a substantial risk factor for unfavorable ATT outcomes, especially after LTFU. The rates of treatment success in RLTFU are distant from the WHO End TB Strategy targets throughout Brazil. These findings underscore the need for targeted interventions to improve treatment adherence and outcomes in persons who experience RLTFU. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Nationwide Economic Analysis of Pulmonary Tuberculosis in Brazil Over Seven Years: Prioritizing Vulnerable Populations for Enhanced Treatment Strategies
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Barreto-Duarte, Beatriz, primary, Villalva-Serra, Klauss, additional, Campos, Vanessa M. S., additional, Cordeiro-Santos, Marcelo, additional, Kritski, Afranio L., additional, Araújo-Pereira, Mariana, additional, Rodrigues, Moreno M. S., additional, and Andrade, Bruno B., additional
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- 2024
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5. Causes of death in children with congenital Zika syndrome in Brazil, 2015 to 2018: A nationwide record linkage study
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Costa, Maria da Conceição N., Cardim, Luciana Lobato, Moore, Cynthia A., de Jesus, Eliene dos Santos, Carvalho-Sauer, Rita, Barreto, Mauricio L., Rodrigues, Laura C., Smeeth, Liam, Schuler-Faccini, Lavínia, Brickley, Elizabeth B., Oliveira, Wanderson K., Carmo, Eduardo Hage, Pescarini, Julia Moreira, Andrade, Roberto F. S., Rodrigues, Moreno M. S., Veiga, Rafael V., Costa, Larissa C., França, Giovanny V. A., Teixeira, Maria Gloria, and Paixão, Enny S.
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Perinatal infection -- Statistics -- Patient outcomes -- Complications and side effects ,Communicable diseases in children -- Statistics -- Complications and side effects -- Patient outcomes ,Pediatric research ,Biological sciences - Abstract
Background Children with congenital Zika syndrome (CZS) have severe damage to the peripheral and central nervous system (CNS), greatly increasing the risk of death. However, there is no information on the sequence of the underlying, intermediate, immediate, and contributing causes of deaths among these children. The aims of this study are describe the sequence of events leading to death of children with CZS up to 36 months of age and their probability of dying from a given cause, 2015 to 2018. Methods and findings In a population-based study, we linked administrative data on live births, deaths, and cases of children with CZS from the SINASC (Live Birth Information System), the SIM (Mortality Information System), and the RESP (Public Health Event Records), respectively. Confirmed and probable cases of CZS were those that met the criteria established by the Brazilian Ministry of Health. The information on causes of death was collected from death certificates (DCs) using the World Health Organization (WHO) DC template. We estimated proportional mortality (PM%) among children with CZS and among children with non-Zika CNS congenital anomalies (CA) by 36 months of age and proportional mortality ratio by cause (PMRc). A total of 403 children with confirmed and probable CZS who died up to 36 months of age were included in the study; 81.9% were younger than 12 months of age. Multiple congenital malformations not classified elsewhere, and septicemia unspecified, with 18 (PM = 4.5%) and 17 (PM = 4.2%) deaths, respectively, were the most attested underlying causes of death. Unspecified septicemia (29 deaths and PM = 11.2%) and newborn respiratory failure (40 deaths and PM = 12.1%) were, respectively, the predominant intermediate and immediate causes of death. Fetuses and newborns affected by the mother's infectious and parasitic diseases, unspecified cerebral palsy, and unspecified severe protein-caloric malnutrition were the underlying causes with the greatest probability of death in children with CZS (PMRc from 10.0 to 17.0) when compared to the group born with non-Zika CNS anomalies. Among the intermediate and immediate causes of death, pneumonitis due to food or vomiting and unspecified seizures (PMRc = 9.5, each) and unspecified bronchopneumonia (PMRc = 5.0) were notable. As contributing causes, fetus and newborn affected by the mother's infectious and parasitic diseases (PMRc = 7.3), unspecified cerebral palsy, and newborn seizures (PMRc = 4.5, each) were more likely to lead to death in children with CZS than in the comparison group. The main limitations of this study were the use of a secondary database without additional clinical information and potential misclassification of cases and controls. Conclusion The sequence of causes and circumstances involved in the deaths of the children with CZS highlights the greater vulnerability of these children to infectious and respiratory conditions compared to children with abnormalities of the CNS not related to Zika., Author(s): Maria da Conceição N. Costa 1,2, Luciana Lobato Cardim 1, Cynthia A. Moore 3, Eliene dos Santos de Jesus 2,4, Rita Carvalho-Sauer 2,5, Mauricio L. Barreto 1,2, Laura C. [...]
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- 2023
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6. Machine learning algorithms using national registry data to predict loss to follow- up during tuberculosis treatment
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Rodrigues, Moreno M. S., primary, Barreto-Duarte, Beatriz, additional, Vinhaes, Caian L., additional, Araújo-Pereira, Mariana, additional, Fukutani, Eduardo R., additional, Bergamaschi, Keityane Bone, additional, Kristki, Afrânio, additional, Cordeiro-Santos, Marcelo, additional, Rolla, Valeria C., additional, Sterling, Timothy R., additional, Queiroz, Artur T. L., additional, and Andrade, Bruno B., additional
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- 2023
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7. Retreatment and Antituberculosis Therapy Outcomes in Brazil between 2015 and 2022: A Nationwide Study of Disease Registry Data
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Barreto-Duarte, Beatriz, primary, Villalva-Serra, Klauss, additional, Miguez-Pinto, João P., additional, Araújo-Pereira, Mariana, additional, Campos, Vanessa M. S., additional, Rosier, Gabriela, additional, Nogueira, Betania M. F., additional, Queiroz, Artur T. L., additional, Rolla, Valeria C., additional, Cordeiro-Santos, Marcelo, additional, Kritski, Afranio L., additional, Rebeiro, Peter F., additional, Sterling, Timothy R., additional, Rodrigues, Moreno M. S., additional, and Andrade, Bruno B., additional
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- 2023
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8. Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil
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Villalva-Serra, Klauss, primary, Barreto-Duarte, Beatriz, additional, Nunes, Vanessa M., additional, Menezes, Rodrigo C., additional, Rodrigues, Moreno M. S., additional, Queiroz, Artur T. L., additional, Arriaga, María B., additional, Cordeiro-Santos, Marcelo, additional, Kritski, Afrânio L., additional, Sterling, Timothy R., additional, Araújo-Pereira, Mariana, additional, and Andrade, Bruno B., additional
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- 2022
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9. Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil
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Villalva-Serra, Klauss, Barreto-Duarte, Beatriz, Nunes, Vanessa M., Menezes, Rodrigo C., Rodrigues, Moreno M. S., Queiroz, Artur T. L., Arriaga, María B., Cordeiro-Santos, Marcelo, Kritski, Afrânio L., Sterling, Timothy R., Araújo-Pereira, Mariana, and Andrade, Bruno B.
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tuberculosis ,diabetes ,treatment outcome ,HIV ,General Medicine ,Antiretroviral therapy (ART) - Abstract
BackgroundTuberculosis (TB) is a worldwide public health problem, especially in countries that also report high numbers of people living with HIV (PLWH) and/or diabetes mellitus (DM). However, the unique features of persons with TB-HIV-DM are incompletely understood. This study compared anti-TB treatment (ATT) outcomes of diabetic and non-diabetic TB/HIV co-infected patients.MethodsA nationwide retrospective observational investigation was performed with data from the Brazilian Tuberculosis Database System among patients reported to have TB-HIV co-infection between 2014 and 2019. This database includes all reported TB cases in Brazil. Exploratory and association analyses compared TB treatment outcomes in DM and non-DM patients. Unfavorable outcomes were defined as death, treatment failure, loss to follow-up or recurrence. Multivariable stepwise logistic regressions were used to identify the variables associated with unfavorable ATT outcomes in the TB-HIV population.ResultsOf the 31,070 TB-HIV patients analyzed, 999 (3.2%) reported having DM. However, in these TB-HIV patients, DM was not associated with any unfavorable treatment outcome [adjusted Odds Ratio (aOR): 0.97, 95% CI: 0.83–1.12, p = 0.781]. Furthermore, DM was also not associated with any specific type of unfavorable outcome in this study. In both the TB-HIV group and the TB-HIV-DM subpopulation, use of alcohol, illicit drugs and tobacco, as well as non-white ethnicity and prior TB were all characteristics more frequently observed in persons who experienced an unfavorable ATT outcome.ConclusionDM is not associated with unfavorable TB treatment outcomes in persons with TB-HIV, including death, treatment failure, recurrence and loss to follow up. However, consumption habits, non-white ethnicity and prior TB are all more frequently detected in those with unfavorable outcomes in both TB-HIV and TB-HIV-DM patients.
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- 2022
10. Profile of COVID-19 in Brazil: Risk Factors and Socioeconomic Vulnerability Associated with Disease Outcome
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Pereira, Felipe A.C., primary, Filho, Fábio M.H.S., additional, de Azevedo, Arthur R., additional, de Oliveira, Guilherme L., additional, Flores-Ortiz, Renzo, additional, Valencia, Luis Iván O., additional, Rodrigues, Moreno M. S., additional, Ramos, Pablo I. P., additional, da Silva, Nívea B., additional, and Oliveira, Juliane Fonseca, additional
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- 2022
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11. Tuberculosis Burden and Determinants of Treatment Outcomes According to Age in Brazil: A Nationwide Study of 896,314 Cases Reported Between 2010 and 2019
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Barreto-Duarte, Beatriz, primary, Araújo-Pereira, Mariana, additional, Nogueira, Betânia M. F., additional, Sobral, Luciana, additional, Rodrigues, Moreno M. S., additional, Queiroz, Artur T. L., additional, Rocha, Michael S., additional, Nascimento, Vanessa, additional, Souza, Alexandra B., additional, Cordeiro-Santos, Marcelo, additional, Kritski, Afrânio L., additional, Sterling, Timothy R., additional, Arriaga, María B., additional, and Andrade, Bruno B., additional
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- 2021
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12. Tuberculosis Burden and Determinants of Treatment Outcomes According to Age in Brazil: A Nationwide Ecological Study of 896,314 Cases Reported between 2010 and 2019
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Barreto Duarte, Beatriz, primary, Araújo-Pereira, Mariana, additional, Nogueira, Betania M. F., additional, Sobral, Luciana, additional, Rodrigues, Moreno M. S., additional, Queiroz, Artur T. L., additional, Rocha, Michael S., additional, Nascimento, Vanessa, additional, Souza, Alexandra Brito, additional, Cordeiro-Santos, Marcelo, additional, Kritski, Afranio L., additional, Sterling, Timothy R., additional, Arriaga, María B., additional, and Andrade, Bruno B., additional
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- 2021
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13. Representativeness of a Large Multicenter Observational Cohort of Tuberculosis Patients: The Example of RePORT Brazil
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Arriaga, María, Amorin, Gustavo, Queiroz, Artur Trancoso Lopo De, Rodrigues, Moreno M. S., Pereira, Mariana Araújo, Betânia Mara De Freitas Nogueira, Souza, Alexandra Brito, Rocha, Michael S., Benjamin, Aline, Moreira, Adriana Da S. R., Oliveira, Jamile G. De, Figueiredo, Marina Cruvinel, Turner, Megan M., Kleydson Alves, Durovni, Betina, Silva, José R. Lapa E, Afranio L Kritski, Cavalcante, Solange C, Rolla, Valeria Cavalcanti, Cordeiro-Santos, Marcelo, Sterling, Timothy R, and Andrade, Bruno Bezerril
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- 2020
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14. The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study.
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Arriaga, María B, Araújo-Pereira, Mariana, Barreto-Duarte, Beatriz, Nogueira, Betânia, Freire, Maria Vitória C N S, Queiroz, Artur T L, Rodrigues, Moreno M S, Rocha, Michael S, Souza, Alexandra B, Spener-Gomes, Renata, Carvalho, Anna Cristina C, Figueiredo, Marina C, Turner, Megan M, Durovni, Betina, Lapa-e-Silva, José R, Kritski, Afrânio L, Cavalcante, Solange, Rolla, Valeria C, Cordeiro-Santos, Marcelo, and Sterling, Timothy R
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PREDIABETIC state ,HIV infections ,GLYCOSYLATED hemoglobin ,TREATMENT effectiveness ,DIABETES ,DRUG therapy for tuberculosis ,TUBERCULOSIS complications ,RESEARCH ,RESEARCH methodology ,EVALUATION research ,COMPARATIVE studies ,ANTITUBERCULAR agents ,LONGITUDINAL method ,DISEASE complications - Abstract
Background: It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).Methods: Culture-confirmed, drug-susceptible PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort between 2015 and 2019 (N = 643) were stratified based on glycemic status according to baseline glycated hemoglobin. Unfavorable tuberculosis (TB) outcome was defined as treatment failure or modification, recurrence, or death; favorable outcome was cure or treatment completion. We corroborated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015-2019 (N = 20 989). Logistic regression models evaluated associations between glycemic status and outcomes.Results: In both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with smoking, illicit drug use, and human immunodeficiency virus infection. Diabetes, but not prediabetes, was associated with unfavorable outcomes in the RePORT-Brazil (adjusted relative risk [aRR], 2.45; P < .001) and SINAN (aRR, 1.76; P < .001) cohorts. Furthermore, diabetes was associated with high risk of death (during TB treatment) in both RePORT-Brazil (aRR, 2.16; P = .040) and SINAN (aRR, 1.93; P = .001).Conclusions: Diabetes was associated with an increased risk of unfavorable outcomes and mortality in Brazilian PWTB. Interventions to improve TB treatment outcomes in persons with diabetes are needed. [ABSTRACT FROM AUTHOR]- Published
- 2022
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15. FRI0450 MEASURES OF DISEASE SEVERITY PREDICT DISABILITY AND QUALITY OF LIFE DIFFERENTLY IN RHEUMATOID ARTHRITIS AND CHRONIC CHIKUNGUNYA DISEASE
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Watson, H., primary, Nogueira-Hayd, R. L., additional, Rodrigues-Moreno, M., additional, Naveca, F., additional, Calusi, G., additional, Amdur, R., additional, Suchowiecki, K., additional, Firestein, G. S., additional, Simon, G., additional, and Chang, A., additional
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- 2020
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16. Representativeness of a Large Multicenter Observational Cohort of Tuberculosis Patients: The Example of RePORT Brazil
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Arriaga, María B., primary, Amorim, Gustavo, additional, Queiroz, Artur T. L., additional, Rodrigues, Moreno M. S., additional, Araújo-Pereira, Mariana, additional, Nogueira, Betania M. F., additional, Souza, Alexandra Brito, additional, Rocha, Michael S., additional, Benjamin, Aline, additional, Moreira, Adriana S. R., additional, de Oliveira, Jamile G., additional, Figueiredo, Marina C., additional, Turner, Megan M., additional, Alves, Kleydson, additional, Durovni, Betina, additional, Lapa-e-Silva, José R., additional, Kritski, Afranio L., additional, Cavalcante, Solange, additional, Rolla, Valeria C., additional, Cordeiro-Santos, Marcelo, additional, Sterling, Timothy R., additional, Andrade, Bruno B., additional, and Consortium, RePORT Brazil, additional
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- 2020
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17. Effect of acute and chronic exposure to ammonia on different larval instars of Anopheles darlingi (Diptera: Culicidae)
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Dias, Alyne C. A., primary, Rodrigues, Moreno M. S., additional, and Silva, Alexandre A., additional
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- 2019
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18. Machine learning algorithms using national registry data to predict loss to follow- up during tuberculosis treatment.
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Rodrigues MMS, Barreto-Duarte B, Vinhaes CL, Araújo-Pereira M, Fukutani ER, Bergamaschi KB, Kristki A, Cordeiro-Santos M, Rolla VC, Sterling TR, Queiroz ATL, and Andrade BB
- Abstract
Background: Identifying patients at increased risk of loss to follow-up (LTFU) is key to developing strategies to optimize the clinical management of tuberculosis (TB). The use of national registry data in prediction models may be a useful tool to inform healthcare workers about risk of LTFU. Here we developed a score to predict the risk of LTFU during anti-TB treatment (ATT) in a nationwide cohort of cases using clinical data reported to the Brazilian Notifiable Disease Information System (SINAN)., Methods: We performed a retrospective study of all TB cases reported to SINAN between 2015-2022; excluding children (<18 years-old), vulnerable groups or drug-resistant TB. For the score, data before treatment initiation were used. We trained and internally validated three different prediction scoring systems, based on Logistic Regression, Random Forest, and Light Gradient Boosting. Before applying our models we split our data into train (~80% data) and test (~20%), and then we compare model metrics using a test data set., Results: Of the 243,726 cases included, 41,373 experienced LTFU whereas 202,353 were successfully treated and cured. The groups were different with regards to several clinical and sociodemographic characteristics. The directly observed treatment (DOT) was unbalanced between the groups with lower prevalence in those who were LTFU. Three models were developed to predict LTFU using 8 features (prior TB, drug use, age, sex, HIV infection and schooling level) with different score composition approaches. Those prediction scoring system exhibited an area under the curve (AUC) ranging between 0.71 and 0.72. The Light Gradient Boosting technique resulted in the best prediction performance, weighting specificity, and sensibility. A user-friendly web calculator app was created (https://tbprediction.herokuapp.com/) to facilitate implementation., Conclusions: Our nationwide risk score predicts the risk of LTFU during ATT in Brazilian adults prior to treatment commencement. This is a potential tool to assist in decision-making strategies to guide resource allocation, DOT indications, and improve TB treatment adherence., Competing Interests: Declaration of Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All other authors declare no competing interests. Potential conflicts of interest: All authors: No reported conflicts of interest.
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- 2023
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19. Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil.
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Arriaga MB, Araújo-Pereira M, Barreto-Duarte B, Sales C, Miguez-Pinto JP, Nogueira EB, Nogueira BMF, Rocha MS, Souza AB, Benjamin A, de Oliveira JG, Moreira ASR, Queiroz ATL, Rodrigues MMS, Spener-Gomes R, Figueiredo MC, Durovni B, Cavalcante S, Lapa-E-Silva JR, Kristki AL, Cordeiro-Santos M, Sterling TR, Rolla VC, and Andrade BB
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Background: There are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) and dysglycemia (diabetes [DM] and prediabetes [PDM]), especially in TB-endemic countries., Methods: We assessed the baseline epidemiological and clinical characteristics of patients with culture-confirmed pulmonary TB, enrolled in a multicenter prospective cohort in Brazil (RePORT-Brazil) during 2015-2019. Dysglycemia was defined by elevated glycated hemoglobin and stratified as PDM or DM. Additionally, we used data from TB cases obtained through the Brazilian National Notifiable Diseases Information System (SINAN), during 2015-2019. In SINAN, diagnosis of diabetes was based on self-report. Logistic regression models were performed to test independent associations between HIV, dysglycemia status, and other baseline characteristics in both cohorts., Results: In the RePORT-Brazil cohort, the prevalence of DM and of PDM was 23.7 and 37.8%, respectively. Furthermore, the prevalence of HIV was 21.4% in the group of persons with TB-dysglycemia and 20.5% in that of patients with TBDM. In the SINAN cohort, the prevalence of DM was 9.2%, and among the TBDM group the prevalence of HIV was 4.1%. Logistic regressions demonstrated that aging was independently associated with PDM or DM in both the RePORT-Brazil and SINAN cohorts. In RePORT-Brazil, illicit drug use was associated with PDM, whereas a higher body mass index (BMI) was associated with DM occurrence. Of note, HIV was not associated with an increased risk of PDM or DM in patients with pulmonary TB in both cohorts. Moreover, in both cohorts, the TBDM-HIV group presented with a lower proportion of positive sputum smear and a higher frequency of tobacco and alcohol users., Conclusion: There is a high prevalence of dysglycemia in patients with pulmonary TB in Brazil, regardless of the HIV status. This reinforces the idea that DM should be systematically screened in persons with TB. Presence of HIV does not substantially impact clinical presentation in persons with TBDM, although it is associated with more frequent use of recreational drugs and smear negative sputum samples during TB screening., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Arriaga, Araújo-Pereira, Barreto-Duarte, Sales, Miguez-Pinto, Nogueira, Nogueira, Rocha, Souza, Benjamin, de Oliveira, Moreira, Queiroz, Rodrigues, Spener-Gomes, Figueiredo, Durovni, Cavalcante, Lapa-e-Silva, Kristki, Cordeiro-Santos, Sterling, Rolla, Andrade and the RePORT-Brazil consortium.)
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- 2022
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20. Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis.
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Watson H, Nogueira-Hayd RL, Rodrigues-Moreno M, Naveca F, Calusi G, Suchowiecki K, Firestein GS, Simon G, and Chang AY
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- Adult, Arthritis virology, Chikungunya Fever pathology, Chikungunya Fever virology, Chikungunya virus isolation & purification, Cross-Sectional Studies, Disability Evaluation, Disabled Persons, Female, Humans, Joints virology, Middle Aged, Pain etiology, Pain pathology, Pain virology, Quality of Life, Severity of Illness Index, Arthritis pathology, Arthritis, Rheumatoid pathology, Chikungunya Fever complications, Joints pathology
- Abstract
Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. The association of tenderness and swelling, clinically assessed in 28 joints, and patient evaluations of pain and musculoskeletal stiffness with modified Health Assessment Questionnaire (HAQ) and quality of life (QoL) assessments were investigated. Tender and swollen joint counts, pain and stiffness scores were all associated with the HAQ disability index in RA (all r > 0.55, p ≤ 0.0002), but only stiffness was significantly associated with disability in chikungunya (r = 0.38, p = 0.02). Joint counts, pain and stiffness were also associated with most QoL domains in RA patients. In contrast, in chikungunya disease, tender joint counts were associated only with one QoL domain and swollen joints for none, while pain and stiffness were associated with several domains. Our results confirm the relevance of joint counts in RA, but suggest that in chronic chikungunya disease, joint counts have more limited value. Stiffness and pain score may be more important to quantify chikungunya arthritis impact., (© 2021. The Author(s).)
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- 2021
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21. Novel stepwise approach to assess representativeness of a large multicenter observational cohort of tuberculosis patients: The example of RePORT Brazil.
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Arriaga MB, Amorim G, Queiroz ATL, Rodrigues MMS, Araújo-Pereira M, Nogueira BMF, Souza AB, Rocha MS, Benjamin A, Moreira ASR, de Oliveira JG, Figueiredo MC, Turner MM, Alves K, Durovni B, Lapa-E-Silva JR, Kritski AL, Cavalcante S, Rolla VC, Cordeiro-Santos M, Sterling TR, and Andrade BB
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- Adult, Brazil epidemiology, Cohort Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome, Tuberculosis complications, Tuberculosis epidemiology, Tuberculosis therapy
- Abstract
Background: A major goal of tuberculosis (TB) epidemiological studies is to obtain results that can be generalized to the larger population with TB. The ability to extrapolate findings on the determinants of TB treatment outcomes is also important., Methods: We compared baseline clinical and demographic characteristics and determinants of anti-TB treatment outcomes between persons enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort between June 2015 and June 2019, and the registry of TB cases reported to the Brazilian National TB Program (Information System for Notifiable Diseases [SINAN]) during the same time period. Multivariable regression models adjusted for the study site were performed using second-generation p-values, a novel statistical approach. Associations with unfavorable treatment outcomes were tested for both RePORT-Brazil and SINAN cohorts., Findings: A total of 1,060 culture-confirmed TB patients were enrolled in RePORT-Brazil and 455,873 TB cases were reported to SINAN. Second-generation p-value analyses revealed that the cohorts were strikingly similar with regard to sex, age, use of antiretroviral therapy and positive initial smear sputum microscopy. However, diabetes, HIV infection, and smoking were more frequently documented in RePORT-Brazil. Illicit drug use, the presence of diabetes, and history of prior TB were associated with unfavorable TB treatment outcomes; illicit drug use was associated with such outcomes in both cohorts., Conclusions: There were important similarities in demographic characteristics and determinants of clinical outcomes between the RePORT-Brazil cohort and the Brazilian National registry of TB cases., Competing Interests: Declaration of Competing Interest The authors report no declarations of interest., (Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2021
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