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436 results on '"Rodríguez-Rojas, Rafael"'

1. Subthalamic Nucleus and Substantia Nigra Automatic Segmentation Using Convolutional Segmentation Transformers (Conv-SeTr)

Author

Nebel, Juan, Pinargote, Franklin E. Magallanes, Peláez, Colon Enrique, Paredes, Francis R. Loayza, Rodriguez-Rojas, Rafael, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Alvaro, editor, Adeli, Hojjat, editor, Dzemyda, Gintautas, editor, Moreira, Fernando, editor, and Colla, Valentina, editor

Published
2024
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2. Skull Density Ratio as Arm‐Allocation Parameter for a Controlled Focused Ultrasound Trial in Parkinson's Disease

Author

Pineda‐Pardo, José Angel, primary, Martínez‐Fernández, Raul, additional, Natera‐Villalba, Elena, additional, Ruiz‐Yanzi, Agustina, additional, Rodríguez‐Rojas, Rafael, additional, Del Alamo, Marta, additional, Jiménez‐Castellanos, Tamara, additional, Matarazzo, Michele, additional, Gasca‐Salas, Carmen, additional, Rascol, Olivier, additional, and Obeso, José A., additional

Published
2024
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3. Staged Bilateral MRI-Guided Focused Ultrasound Subthalamotomy for Parkinson Disease

Author

Martínez-Fernández, Raúl, primary, Natera-Villalba, Elena, additional, Rodríguez-Rojas, Rafael, additional, del Álamo, Marta, additional, Pineda-Pardo, Jose A., additional, Obeso, Ignacio, additional, Guida, Pasqualina, additional, Jiménez-Castellanos, Tamara, additional, Pérez-Bueno, Diana, additional, Duque, Alicia, additional, Mañez-Miró, Jorge U., additional, Gasca-Salas, Carmen, additional, Matarazzo, Michele, additional, Alonso-Frech, Fernando, additional, and Obeso, Jose A., additional

Published
2024
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4. Cognitive Reserve in Parkinson's Disease without Dementia: β‐Amyloid and Metabolic Assessment

Author

Fernández‐Rodríguez, Beatriz, primary, Rodríguez‐Rojas, Rafael, additional, Guida, Pasqualina, additional, Angulo‐Díaz‐Parreño, Santiago, additional, Trompeta, Clara, additional, Mata‐Marín, David, additional, Obeso, Ignacio, additional, Vela, Lydia, additional, Plaza de las Heras, Isabel, additional, Obeso, José A., additional, and Gasca‐Salas, Carmen, additional

Published
2024
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8. Brain hypometabolism in non‐demented microtubule‐associated protein tau H1 carriers with Parkinson's disease

Author

Gasca‐Salas, Carmen, primary, Trompeta, Clara, additional, López‐Aguirre, Miguel, additional, Rodríguez Rojas, Rafael, additional, Clarimon, Jordi, additional, Dols‐Icardo, Oriol, additional, El Bounasri, Shaimaa, additional, Guida, Pasqualina, additional, Mata‐Marín, David, additional, Hernández‐Fernández, Frida, additional, Marras, Connie, additional, García‐Cañamaque, Lina, additional, Plaza de las Heras, Isabel, additional, Obeso, Ignacio, additional, Vela, Lydia, additional, and Fernández‐Rodríguez, Beatriz, additional

Published
2023
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10. BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

Author

Blesa, Javier, primary, Pineda-Pardo, José A., additional, Inoue, Ken-ichi, additional, Gasca-Salas, Carmen, additional, Balzano, Tiziano, additional, Del Rey, Natalia López-González, additional, Reinares-Sebastián, Alejandro, additional, Esteban-García, Noelia, additional, Rodríguez-Rojas, Rafael, additional, Márquez, Raquel, additional, Ciorraga, María, additional, del Álamo, Marta, additional, García-Cañamaque, Lina, additional, Ruiz de Aguiar, Santiago, additional, Rachmilevitch, Itay, additional, Trigo-Damas, Inés, additional, Takada, Masahiko, additional, and Obeso, José A., additional

Published
2023
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12. Neuroimages in Autism

Author

Rodríguez-Rojas, Rafael, Machado, Calixto, Batista, Karla, Carballo, Maylen, Leisman, Gerry, and Robinson-Agramonte, Maria de los Angeles, editor

Published
2015
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13. Using Graph Theory to Identify Aberrant Hierarchical Patterns in Parkinsonian Brain Networks

Author

Rodriguez-Rojas, Rafael, Sanabria, Gretel, Melie, Lester, Morales, Juan-Miguel, Carballo, Maylen, Garcia, David, Obeso, Jose A., Rodriguez-Oroz, Maria C., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ruiz-Shulcloper, José, editor, and Sanniti di Baja, Gabriella, editor

Published
2013
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14. Striatal Blood–Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study

Author

Pineda‐Pardo, José A., primary, Gasca‐Salas, Carmen, additional, Fernández‐Rodríguez, Beatriz, additional, Rodríguez‐Rojas, Rafael, additional, del Álamo, Marta, additional, Obeso, Ignacio, additional, Hernández‐Fernández, Frida, additional, Trompeta, Clara, additional, Martínez‐Fernández, Raúl, additional, Matarazzo, Michele, additional, Mata‐Marín, David, additional, Guida, Pasqualina, additional, Duque, Alicia, additional, Albillo, David, additional, Plaza de las Heras, Isabel, additional, Montero, Juan I., additional, Foffani, Guglielmo, additional, Toltsis, Gabriella, additional, Rachmilevitch, Itay, additional, Blesa, Javier, additional, and Obeso, José A., additional

Published
2022
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15. Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism

Author

Molinet-Dronda, Francisco, primary, Blesa, Javier, additional, del Rey, Natalia López-González, additional, Juri, Carlos, additional, Collantes, María, additional, Pineda-Pardo, Jose A, additional, Trigo-Damas, Inés, additional, Iglesias, Elena, additional, Hernández, Ledia F., additional, Rodríguez-Rojas, Rafael, additional, Gago, Belén, additional, Ecay, Margarita, additional, Prieto, Elena, additional, García-Cabezas, Miguel Á., additional, Cavada, Carmen, additional, Rodríguez-Oroz, María C., additional, Peñuelas, Iván, additional, and Obeso, José A., additional

Published
2022
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20. Cambios estructurales y funcionales inducidos por subtalamotomía en el tratamiento de pacientes con enfermedad de Parkinson

Author

Rodríguez Rojas, Rafael., Obeso, José A., CEU Escuela Internacional de Doctorado (CEINDO). Universidad San Pablo-CEU., and Universidad San Pablo-CEU. Facultad de Medicina.

Subjects
Subtalamotomía, Positron emission tomography, Magnetic resonance imaging, Subthalamotomy, Ultrasonido focal guiado por resonancia magnética, Resonancia magnética, Parkinson’s disease, Tractografía, Tomografía por emisión de positrones, Magnetic resonance-guided focused ultrasound, Tractography
Abstract

Tesis-CEINDO, Universidad San Pablo CEU, Programa en Medicina Traslacional, leida el 12 de junio 2020 La enfermedad de Parkinson (EP) es un proceso neurodegenerativo complejo, caracterizado por la presencia de rigidez, bradicinesia y temblor de reposo. La termoablación de la región motora del subtálamo mediante radiofrecuencia o ultrasonido focal guiado por resonancia magnética (MRgFUS) modula la actividad cortical patológica y disminuye las complicaciones motoras asociadas. No obstante, los mecanismos anatómicos y fisiológicos que soportan esta mejoría no han sido estudiados en detalle. Esta investigación utiliza avanzadas técnicas de adquisición, procesamiento y análisis de imágenes para caracterizar, por primera vez, los cambios en la arquitectura anatómica y funcional de los circuitos ganglios basales-tálamo corticales, inducidos por subtalamotomía. Nuestros resultados indican que la subtalamotomía es un método seguro, eficaz y mínimamente invasivo para el tratamiento de los síntomas motores de la EP. La topografía de la lesión ideal combina el impacto motor en el subtálamo con el efecto anti-discinético de la interrupción de las fibras pálido-fugales. Esta técnica desplaza el patrón metabólico relacionado con la EP hacia valores normales. La correlación de la mejoría en los signos motores con los cambios en distintos marcadores de neuroimágenes, indican que la subtalamotomía opera a través de un amplio efecto modulador sobre las redes anátomo-funcionales del cerebro. Parkinson's disease (PD) is a complex neurodegenerative process, characterized by the presence of rigidity, bradykinesia, and tremor. Thermoablation of the motor region of the subthalamic nucleus using radiofrequency or magnetic resonance-guided focal ultrasound (MRgFUS) modulates pathological cortical activity and reduces associated motor complications. However, the anatomical and physiological mechanisms that support this improvement have not been studied in detail. Using advanced image acquisition, processing and analysis techniques, this study aims to characterize, for the first time, the changes induced by subthalamotomy in the anatomical and functional architecture of the basal ganglia-thalamus-cortical circuits. Our results indicate that subthalamotomy is a safe, effective and minimally invasive method for treating the motor symptoms of PD. The ideal lesion topography combines the motor impact on the subthalamus with the anti-dyskinetic effect of the disruption of the pallidus-fugal fibers. This technique shifts the metabolic pattern related to PD towards normal values. The correlation of the improvement in motor signs with changes in different neuroimaging markers indicates that subthalamotomy operates through a broad modulating effect on the anatomical-functional networks of the brain.

Published
2020

21. Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease

Author

Martínez-Fernández, Raúl, primary, Máñez-Miró, Jorge U., additional, Rodríguez-Rojas, Rafael, additional, del Álamo, Marta, additional, Shah, Binit B., additional, Hernández-Fernández, Frida, additional, Pineda-Pardo, José A., additional, Monje, Mariana H.G., additional, Fernández-Rodríguez, Beatriz, additional, Sperling, Scott A., additional, Mata-Marín, David, additional, Guida, Pasqualina, additional, Alonso-Frech, Fernando, additional, Obeso, Ignacio, additional, Gasca-Salas, Carmen, additional, Vela-Desojo, Lydia, additional, Elias, W. Jeffrey, additional, and Obeso, José A., additional

Published
2020
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23. Letter

Author

Pineda-Pardo, José A, primary, Máñez-Miró, Jorge U, additional, López-Aguirre, Miguel, additional, Rodríguez-Rojas, Rafael, additional, Caballero-Insaurriaga, Jaime, additional, M, Del Álamo, additional, Martínez-Fernández, Raúl, additional, and Obeso, José A, additional

Published
2020
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24. Blood-Brain Barrier Opening with Focused Ultrasound in Parkinson’s Disease Dementia: A Safety and Feasibility Study (1131)

Author

Gasca-Salas, Carmen, primary, Fernández-Rodríguez, Beatriz, additional, Pineda-Pardo, José Ángel, additional, Rodríguez-Rojas, Rafael, additional, Hernández, Frida, additional, Obeso, Ignacio, additional, Marín, David Mata, additional, Guida, Pasqualina, additional, del Álamo, Marta, additional, Bandera, Carlos Ordás, additional, Rachmilevitch, Itay, additional, and Obeso, José A., additional

Published
2020
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25. Focused Ultrasound Subthalamotomy in Parkinson’s Disease: Lesion Topography and Motor Improvement. (1124)

Author

Máñez Miró, Jorge U., primary, Rodríguez-Rojas, Rafael, additional, Martínez-Fernández, Raúl, additional, Del Álamo, Marta, additional, Pineda-Pardo, José A., additional, Hernández-Fernández, Frida, additional, De Luis-Pastor, Esther, additional, Monje, MHG, additional, Fernández-Rodríguez, Beatriz, additional, Alonso-Frech, Fernando, additional, Vela, Lydia, additional, and Obeso, José A., additional

Published
2020
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26. Transcranial Magnetic Resonance-Guided Focused Ultrasound Thalamotomy in Essential Tremor: A Comprehensive Lesion Characterization

Author

Pineda-Pardo, José Angel, primary, Urso, Daniele, additional, Martínez-Fernández, Raul, additional, Rodríguez-Rojas, Rafael, additional, del-Alamo, Marta, additional, Millar Vernetti, Patricio, additional, Máñez-Miró, Jorge U, additional, Hernández-Fernández, Frida, additional, de Luis-Pastor, Esther, additional, Vela-Desojo, Lydia, additional, and Obeso, José A, additional

Published
2019
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27. Zero TE MRI applications to transcranial MR-guided focused ultrasound: Patient screening and treatment efficiency estimation.

Author

Caballero‐Insaurriaga, Jaime, Rodríguez‐Rojas, Rafael, Martínez‐Fernández, Raúl, Del‐Alamo, Marta, Díaz‐Jiménez, Laura, Ávila, María, Martínez‐Rodrigo, María, García‐Polo, Pablo, Pineda‐Pardo, José A., Caballero-Insaurriaga, Jaime, Rodríguez-Rojas, Rafael, Martínez-Fernández, Raúl, Del-Alamo, Marta, Díaz-Jiménez, Laura, Martínez-Rodrigo, María, García-Polo, Pablo, and Pineda-Pardo, José A

Subjects
SKULL base, TREATMENT effectiveness, IONIZING radiation, ACOUSTIC impedance, REGRESSION analysis
Abstract

Background: The high acoustic impedance of the skull limits the performance of transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) therapy. Subject suitability screening is based on skull parameters estimated from computed tomography (CT) scans.Purpose: To assess the feasibility of screening for tcMRgFUS based on zero echo time (ZTE) MRI, and to explore the influence of measurable skull parameters in treatment performance.Study Type: Retrospective.Population: Sixteen patients treated with tcMRgFUS thalamotomy for tremor.Sequence: ZTE on a 3.0T GE scanner.Assessment: Baseline CT and ZTE images were processed to extract skull measures associated with treatment success: skull density ratio (SDR), skull thickness, and angle of incidence. Eight new metrics were proposed. CT and ZTE-based measures were compared. Each subject's energy-temperature curve was processed to extract a global estimate of efficiency and a measure of nonlinearity. These parameters were then correlated with the skull measures.Statistical Tests: Linear regression analysis to compare ZTE vs. CT-based measures, measures vs. efficiency, and measures vs. nonlinearity. Paired t-test to assess nonlinearity.Results: CT and ZTE-based measures were significantly correlated (P < 0.01). In particular, classical metrics were robustly replicated (P < 0.001). The energy-temperature curves showed a nonlinear (logarithmic) relationship (P < 0.01). This nonlinearity was greater for thicker skulls (P < 0.01). Efficiency was correlated with skull thickness (P < 0.001) and SDR (P < 0.05).Data Conclusion: The feasibility of ZTE-based screening has been proven, potentially making it possible to avoid ionizing radiation and the extra imaging session required for CT. The characterization of the influence that skull properties have on tcMRgFUS may serve to develop patient-specific heating models, potentially improving control over the treatment outcome. The relationship of skull thickness with efficiency and nonlinearity empowers the role of this metric in the definition of such models. In addition, the lower association of SDR with the energy-temperature curves emphasizes the need of revisiting this metric.Level Of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1583-1592. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Microstructural changes of the dentato‐rubro‐thalamic tract after transcranial MR guided focused ultrasound ablation of the posteroventral VIM in essential tremor

Author

Pineda‐Pardo, Jose A., primary, Martínez‐Fernández, Raul, additional, Rodríguez‐Rojas, Rafael, additional, Del‐Alamo, Marta, additional, Hernández, Frida, additional, Foffani, Guglielmo, additional, Dileone, Michele, additional, Máñez‐Miró, Jorge U., additional, De Luis‐Pastor, Esther, additional, Vela, Lydia, additional, and Obeso, José A., additional

Published
2019
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31. Relation of Structural and Functional Changes in Auditory and Visual Pathways after Temporal Lobe Epilepsy Surgery

Author

Báez-Martín, Margarita, primary, Morales-Chacón, Lilia, additional, García-Maeso, Iván, additional, Estupiñán-Díaz, Bárbara, additional, García-Navarro, María, additional, Pérez Téllez, Yamila, additional, Lorigados-Pedre, Lourdes, additional, Quintanal-Cordero, Nelson, additional, Valdés-Llerena, Ricardo, additional, González González, Judith, additional, Garbey-Fernández, Randis, additional, Cabrera-Abreu, Ivette, additional, Alarcón-Calaña, Celia, additional, Bender del Busto, Juan, additional, Rodríguez Rojas, Rafael, additional, Batista García-Ramó, Karla, additional, and Galvizu Sánchez, Reinaldo, additional

Published
2018
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35. Brain Tissue Volumes and Perfusion Change with the Number of Optic Neuritis Attacks in Relapsing Neuromyelitis Optica: A Voxel-Based Correlation Study

Author

Sánchez-Catasús, Carlos A., primary, Cabrera-Gomez, José, additional, Almaguer Melián, William, additional, Giroud Benítez, José Luis, additional, Rodríguez Rojas, Rafael, additional, Bayard, Jorge Bosch, additional, Galán, Lídice, additional, Sánchez, Reinaldo Galvizu, additional, Fuentes, Nancy Pavón, additional, and Valdes-Sosa, Pedro, additional

Published
2013
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36. The number of optic neuritis attacks is a potential confounder when comparing patients with NMO vs. controls by voxel-based neuroimaging analysis.

Author

Sánchez-Catasús, Carlos A., Cabrera-Gomez, José, Almaguer Melián, William, Bosch Bayard, Jorge, Rodríguez Rojas, Rafael, and Valdes-Sosa, Pedro

Subjects
OPTIC neuritis, VOXEL-based morphometry, MAGNETIC resonance imaging, SINGLE-photon emission computed tomography, COMPUTED tomography
Abstract

Background: Voxel-based morphometric (VBM) studies in neuromyelitis optica (NMO) have shown limited reproducibility. A previous study suggests that the number of optic neuritis (ON) attacks may be a confounding factor when comparing NMO patients with controls if it is not taken into account during VBM analysis. Purpose: To investigate the potential confounding effect of the number of ON attacks, for both tissue volumes and perfusion by voxel-based statistical analysis. Material and Methods: Volumetric magnetic resonance imaging (MRI) and perfusion SPECT were obtained from 15 controls and two patient subgroups: subgroup I was composed of nine patients with one or two ON attacks; and subgroup II of six patients with three or four ON attacks. We performed non-parametric voxel-based comparison of tissue volumes and perfusion between controls versus the two patient subgroups and for the whole patient group. Results: Subgroup I presented no volume reductions, contrary to subgroup II that showed unequivocal reduction. We also found hypoperfusion in different brain regions in different subgroups. The results were quite different for the whole patient group. Conclusion: These findings highlight the confounding effect of the number of ON attacks, providing a new methodological insight that could explain the limited reproducibility of previous VBM studies in NMO. [ABSTRACT FROM AUTHOR]

Published
2016
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37. Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study

Author

Suárez-Monteagudo, Carlos, primary, Hernández-Ramírez, Porfirio, additional, Álvarez-González, Lázaro, additional, García-Maeso, Iván, additional, de la Cuétara-Bernal, Karelys, additional, Castillo-Díaz, Lázara, additional, Bringas-Vega, María L., additional, Martínez-Aching, Gilda, additional, Morales-Chacón, Lilia M., additional, Báez-Martín, Margarita M., additional, Sánchez-Catasús, Carlos, additional, Carballo-Barreda, Maylen, additional, Rodríguez-Rojas, Rafael, additional, Gómez-Fernández, Lázaro, additional, Alberti-Amador, Esteban, additional, Macías-Abraham, Consuelo, additional, Balea, Elvira Dorticós, additional, Rosales, Lázaro Cortina, additional, del Valle Pérez, Lázaro, additional, Ferrer, Berta B. Socarrás, additional, González, Raúl Macías, additional, and Bergado, Jorge A., additional

Published
2009
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39. Localización bilateral y simetría del núcleo subtalámico

Author

López Flores, Gerardo, primary, Morales Oliva, Juan Miguel, additional, Tejeiro Amador, Juan, additional, Fernández Melo, Ramsés, additional, Álvarez González, Lázaro, additional, Macías González, Raúl, additional, Cruz García, Orlando, additional, Fermín Hernández, Eduardo, additional, Palmero, Eduardo, additional, Rodríguez Rojas, Rafael, additional, Carballo Barreda, Maylén, additional, and Mosquera Betancourt, Gretel, additional

Published
2003
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40. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study.

Author

Martínez-Fernández, Raul, Rodríguez-Rojas, Rafael, Del Álamo, Marta, Hernández-Fernández, Frida, Pineda-Pardo, Jose A, Dileone, Michele, Alonso-Frech, Fernando, Foffani, Guglielmo, Obeso, Ignacio, Gasca-Salas, Carmen, de Luis-Pastor, Esther, Vela, Lydia, and Obeso, José A

Subjects
*PARKINSON'S disease diagnosis, *DIENCEPHALON, *DIAGNOSTIC imaging, *MAGNETIC resonance imaging, *COMPUTERS in medicine, *HEALTH outcome assessment, *PARKINSON'S disease, *OPERATIVE surgery, *SURGICAL complications, *PILOT projects, *SURGERY, *PSYCHOLOGY
Abstract

Background: Ablative neurosurgery has been used to treat Parkinson's disease for many decades. MRI-guided focused ultrasound allows focal lesions to be made in deep brain structures without skull incision. We investigated the safety and preliminary efficacy of unilateral subthalamotomy by focused ultrasound in Parkinson's disease.Methods: This prospective, open-label pilot study was done at CINAC (Centro Integral de Neurociencias), University Hospital HM Puerta del Sur in Madrid, Spain. Eligible participants had Parkinson's disease with markedly asymmetric parkinsonism. Patients with severe dyskinesia, history of stereotactic surgery or brain haemorrhage, a diagnosis of an unstable cardiac or psychiatric disease, or a skull density ratio of 0·3 or less were excluded. Enrolled patients underwent focused ultrasound unilateral subthalamotomy. The subthalamic nucleus was targeted by means of brain images acquired with a 3-Tesla MRI apparatus. Several sonications above the definitive ablation temperature of 55°C were delivered and adjusted according to clinical response. The primary outcomes were safety and a change in the motor status of the treated hemibody as assessed with part III of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) in both off-medication and on-medication states at 6 months. Adverse events were monitored up to 48 h after treatment and at scheduled clinic visits at 1, 3, and 6 months after treatment. The study is registered with ClinicalTrials.gov, number NCT02912871.Findings: Between April 26 and June 14, 2016, ten patients with markedly asymmetric parkinsonism that was poorly controlled pharmacologically were enrolled for focused ultrasound unilateral subthalamotomy. By 6 months follow-up, 38 incidents of adverse events had been recorded, none of which were serious or severe. Seven adverse events were present at 6 months. Three of these adverse events were directly related to subthalamotomy: off-medication dyskinesia in the treated arm (one patient, almost resolved by 6 months); on-medication dyskinesia in the treated arm (one patient, resolved after levodopa dose reduction); and subjective speech disturbance (one patient). Four of the adverse events present at 6 months were related to medical management (anxiety and fatigue [one patient each] and weight gain [two patients]). The most frequent adverse events were transient gait ataxia (related to subthalamotomy, six patients), transient pin-site head pain (related to the head frame, six patients), and transient high blood pressure (during the procedure, five patients). Transient facial asymmetry (one patient) and moderate impulsivity (two patients) were also recorded. The mean MDS-UPDRS III score in the treated hemibody improved by 53% from baseline to 6 months in the off-medication state (16·6 [SD 2·9] vs 7·5 [3·9]) and by 47% in the on-medication state (11·9 [3·1] vs 5·8 [3·5]).Interpretation: MRI-guided focused ultrasound unilateral subthalamotomy was well tolerated and seemed to improve motor features of Parkinson's disease in patients with noticeably asymmetric parkinsonism. Large randomised controlled trials are necessary to corroborate these preliminary findings and to assess the potential of such an approach to treat Parkinson's disease.Funding: Fundación de investigación HM Hospitales and Insightec. [ABSTRACT FROM AUTHOR]

Published
2017
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41. Hipertermia Electromagnética para el Tratamiento del Cáncer

Author

Yero, D. Deás, González, F. Gilart, Raizer, A., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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43. Cursos de Biomateriales en la Docencia de Pregrado de la Carrera de Ingeniería Biomédica en la Plataforma Moodle

Author

Morejón, L., Estevez, E., Delgado, J. A., Alba, R., Castan, L., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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44. Análisis Crítico sobre la Formación en Ingeniería Biomédica

Author

Avendaño, G. E., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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45. Ambiente Virtual para Treinamento em Obstetrícia

Author

Fonseca, S. R. M., Domingues, A. M., Bissaco, M. A. S., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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46. Sistema de Gestión de Información para la Investigación y Postgrado

Author

Noda, Z., Morera, I., Ojeda, M., López, M., Fernández, S., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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47. Anaglifos en la Enseñanza de la Ingeniería Biomédica

Author

Zottola, D. A., Hernández, A. A., Serra, R., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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49. Experiencias en la enseñanza semipresencial en el Plan de Estudio de Ingeniería Biomédica en el 'Instituto Superior Politécnico José Antonio Echeverría'

Author

Regueiro-Gómez, A., Busoch-Morlán, C. B., Busoch, C. R., Sánchez-Bao, R., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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50. Módulo Tiempo-Frecuencia para el Estudio de los Procesos Cognitivos

Author

Díaz-Comas, L., Martínez, E., Quiñones, I., Galán, L., Reyes, A., Acosta, Y., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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