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191 results on '"Rodríguez-Peralto, J.L."'

1. Different Mutational Profiles of Subcutaneous Panniculitis-like T-cell Lymphoma and Lupus Panniculitis: An Additional Case Series

Author

Machan, S., Rodríguez, M., Manso, R., Borregón, J., Chamizo, C., Alonso-Alonso, R., Rodríguez-Peralto, J.L., Torres Nieto, M.Á., Monteagudo, C., García Toro, E., Cerroni, L., García, C., Estrach, T., García Herrera, A., Ferrer, B., García-Patos, V., Segues, N., Díaz de la Pinta, F.J., Afonso-Martin, J.L., Peñate, Y., Limeres-Gonzalez, M.Á., González-Núñez, M.Á., González-Cruz, C., García Fernández, E., Cereceda, L., Minguez, P., de la Fuente, L., Requena, L., and Rodríguez-Pinilla, S.M.

Published
2024
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3. Granulomas in Dermatopathology: Principal Diagnoses - Part 1

Author

Aróstegui Aguilar, J., Diago, A., Carrillo Gijón, R., Fernández Figueras, M., Fraga, J., García Herrera, A., Garrido, M., Idoate Gastearena, M.A., Christian Laga, A., Llamas-Velasco, M., Martínez Campayo, N., Monteagudo, C., Onrubia, J., Pérez Muñoz, N., Ríos-Martín, J.J., Ríos-Viñuela, E., Rodríguez Peralto, J.L., Rozas Muñoz, E., Sanmartín, O., Santonja, C., Santos-Briz, A., Saus, C., Suárez Peñaranda, J.M., Velasco Benito, V., Beato Merino, M.J., and Fernandez-Flores, A.

Published
2021
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4. Granulomas in Dermatopathology: Principal Diagnoses — Part 2

Author

Aróstegui Aguilar, J., Diago, A., Carrillo Gijón, R., Fernández Figueras, M., Fraga, J., García Herrera, A., Garrido, M., Idoate Gastearena, M.A., Christian Laga, A., Llamas-Velasco, M., Martínez Campayo, N., Monteagudo, C., Onrubia, J., Pérez Muñoz, N., Ríos-Martín, J.J., Ríos-Viñuela, E., Rodríguez Peralto, J.L., Rozas Muñoz, E., Sanmartín, O., Santonja, C., Santos-Briz, A., Saus, C., Suárez Peñaranda, J.M., Velasco Benito, V., Beato Merino, M.J., and Fernandez-Flores, A.

Published
2021
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5. Clinical and Histopathologic Characteristics of the Main Causes of Vascular Occusion — Part II: Coagulation Disorders, Emboli, and Other

Author

Beato Merino, M.J., Diago, A., Fernandez-Flores, A., Fraga, J., García Herrera, A., Garrido, M., Idoate Gastearena, M.A., Llamas-Velasco, M., Monteagudo, C., Onrubia, J., Pérez-González, Y.C., Pérez Muñoz, N., Ríos-Martín, J.J., Ríos-Viñuela, E., Rodríguez Peralto, J.L., Rozas Muñoz, E., Sanmartín, O., Santonja, C., Santos-Briz, A., Saus, C., Suárez Peñaranda, J.M., and Velasco Benito, V.

Published
2021
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7. Clinical and Histopathologic Characteristics of the Main Causes of Vascular Occusion — Part I: Thrombi

Author

Beato Merino, M.J., Diago, A., Fernandez-Flores, A., Fraga, J., García Herrera, A., Garrido, M., Idoate Gastearena, M.A., Llamas-Velasco, M., Monteagudo, C., Onrubia, J., Pérez-González, Y.C., Pérez Muñoz, N., Ríos-Martín, J.J., Ríos-Viñuela, E., Rodríguez Peralto, J.L., Rozas Muñoz, E., Sanmartín, O., Santonja, C., Santos-Briz, A., Saus, C., Suárez Peñaranda, J.M., and Velasco Benito, V.

Published
2021
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16. Granulomas en dermatopatología: principales entidades. Parte II

Author

Aróstegui Aguilar, J., primary, Diago, A., additional, Carrillo Gijón, R., additional, Fernández Figueras, M., additional, Fraga, J., additional, García Herrera, A., additional, Garrido, M., additional, Idoate Gastearena, M.A., additional, Christian Laga, A., additional, Llamas-Velasco, M., additional, Martínez Campayo, N., additional, Monteagudo, C., additional, Onrubia, J., additional, Pérez Muñoz, N., additional, Ríos-Martín, J.J., additional, Ríos-Viñuela, E., additional, Rodríguez Peralto, J.L., additional, Rozas Muñoz, E., additional, Sanmartín, O., additional, Santonja, C., additional, Santos-Briz, A., additional, Saus, C., additional, Suárez Peñaranda, J.M., additional, Velasco Benito, V., additional, Beato Merino, M.J., additional, and Fernandez-Flores, A., additional

Published
2021
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20. SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultraestructural study of 7 paediatric cases

Author

Colmenero, I., Santonja, C., Alonso‐Riaño, M., Noguera‐Morel, L., Hernández‐Martín, A., Andina, D., Wiesner, T., Rodríguez‐Peralto, J.L., Requena, L., and Torrelo, A.

Subjects
Chilblains, Betacoronavirus, SARS-CoV-2, Pneumonia, Viral, COVID-19, Humans, Original Article, Original Articles, Child, Coronavirus Infections, Pandemics, Polymerase Chain Reaction
Abstract

Summary Background Chilblains ("COVID toes") are being seen with increasing frequency in children and young adults during the COVID‐19 pandemic. Detailed histopathological descriptions of COVID‐19 chilblains have not been reported, and causality of SARS‐CoV‐2 has not been established yet. Objective To describe histopathological features of Covid‐19 chilblains and explore the presence of SARS‐CoV‐2 in the tissue. Methods We examined skin biopsies from 7 paediatric patients presenting with chilblains during the COVID‐19 pandemic. Immunohistochemistry for SARS‐CoV‐2 was performed in all cases and electron microscopy in one. Results Histopathology showed variable degrees of lymphocytic vasculitis ranging from endothelial swelling and endothelialitis to fibrinoid necrosis and thrombosis. Purpura, superficial and deep perivascular lymphocytic inflammation with perieccrine accentuation, oedema, and mild vacuolar interface damage were also seen. SARS‐CoV‐2 immunohistochemistry was positive in endothelial cells and epithelial cells of eccrine glands. Coronavirus particles were found in the cytoplasm of endothelial cells on electron microscopy. Conclusions Although the clinical and histopathological features were similar to other forms of chilblains, the presence of viral particles in the endothelium and the histological evidence of vascular damage, support a causal relation of the lesions with SARS‐CoV‐2. Endothelial damage induced by the virus could be the key mechanism in the pathogenesis of COVID‐19 chilblains and perhaps also in a group of patients severely affected by COVID‐19 presenting with features of microangiopathic damage.

Published
2020

21. Dermatopatología de la oclusión intraluminal vascular: parte II (coagulopatías, émbolos y miscelánea)

Author

Beato Merino, M.J., primary, Diago, A., additional, Fernandez-Flores, A., additional, Fraga, J., additional, García Herrera, A., additional, Garrido, M., additional, Idoate Gastearena, M.A., additional, Llamas-Velasco, M., additional, Monteagudo, C., additional, Onrubia, J., additional, Pérez-González, Y.C., additional, Pérez Muñoz, N., additional, Ríos-Martín, J.J., additional, Ríos-Viñuela, E., additional, Rodríguez Peralto, J.L., additional, Rozas Muñoz, E., additional, Sanmartín, O., additional, Santonja, C., additional, Santos-Briz, A., additional, Saus, C., additional, Suárez Peñaranda, J.M., additional, and Velasco Benito, V., additional

Published
2021
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22. Guía de práctica clínica de melanoma de la Academia Española de Dermatología y Venereología

Author

Botella-Estrada, R., primary, Boada-García, A., additional, Carrera-Álvarez, C., additional, Fernández-Figueras, M., additional, González-Cao, M., additional, Moreno-Ramírez, D., additional, Nagore, E., additional, Ríos-Buceta, L., additional, Rodríguez-Peralto, J.L., additional, Samaniego-González, E., additional, Tejera-Vaquerizo, A., additional, Vílchez-Márquez, F., additional, Descalzo-Gallego, M.A., additional, and García-Doval, I., additional

Published
2021
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23. Dermatopatología de la oclusión intraluminal vascular: parte I (trombos)

Author

Beato Merino, M.J., primary, Diago, A., additional, Fernández-Flores, Á., additional, Fraga, J., additional, García Herrera, A., additional, Garrido, M., additional, Idoate Gastearena, M.Á., additional, Llamas-Velasco, M., additional, Monteagudo, C., additional, Onrubia, J., additional, Pérez-González, Y.C., additional, Pérez Muñoz, N., additional, Ríos-Martín, J.J., additional, Ríos-Viñuela, E., additional, Rodríguez Peralto, J.L., additional, Rozas Muñoz, E., additional, Sanmartín, O., additional, Santonja, C., additional, Santos-Briz, Á., additional, Saus, C., additional, Suárez Peñaranda, J.M., additional, and Velasco Benito, V., additional

Published
2021
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24. Primary cutaneous peripheral T‐cell lymphoma, not otherwise specified: results of a multicentre European Organization for Research and Treatment of Cancer (EORTC) cutaneous lymphoma taskforce study on the clinico‐pathological and prognostic features

Author

Kempf, W., primary, Mitteldorf, C., additional, Battistella, M., additional, Willemze, R., additional, Cerroni, L., additional, Santucci, M., additional, Geissinger, E., additional, Jansen, P., additional, Vermeer, M.H., additional, Marschalko, M., additional, Papadavid, E., additional, Piris, M.A., additional, Ortiz‐Romero, P.L., additional, Novelli, M., additional, Paulli, M., additional, Quaglino, P., additional, Ranki, A., additional, Rodríguez Peralto, J.L., additional, Wobser, M., additional, Auschra, B., additional, and Robson, A., additional

Published
2020
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28. SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

Author

Colmenero, I., primary, Santonja, C., additional, Alonso‐Riaño, M., additional, Noguera‐Morel, L., additional, Hernández‐Martín, A., additional, Andina, D., additional, Wiesner, T., additional, Rodríguez‐Peralto, J.L., additional, Requena, L., additional, and Torrelo, A., additional

Published
2020
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29. Prognostic metabolic markers in cutaneous melanoma

Author

Nájera, L., primary, Alonso‐Juarranz, M., additional, Garrido, M., additional, Ballestín, C., additional, Moya, L., additional, Martínez‐Díaz, M., additional, Carrillo, R., additional, Juarranz, A., additional, Rojo, F., additional, Cuezva, J.M., additional, and Rodríguez‐Peralto, J.L., additional

Published
2019
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30. 代谢表型标志物对人类皮肤黑色素瘤预后的影响

Author

Nájera, L., primary, Alonso‐Juarranz, M., additional, Garrido, M., additional, Ballestín, C., additional, Moya, L., additional, Martínez‐Díaz, M., additional, Carrillo, R., additional, Juarranz, A., additional, Rojo, F., additional, Cuezva, J.M., additional, and Rodríguez‐Peralto, J.L., additional

Published
2019
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32. Primary cutaneous peripheral T‐cell lymphoma, not otherwise specified: results of a multicentre European Organization for Research and Treatment of Cancer (EORTC) cutaneous lymphoma taskforce study on the clinico‐pathological and prognostic features

Author

Kempf, W., Mitteldorf, C., Battistella, M., Willemze, R., Cerroni, L., Santucci, M., Geissinger, E., Jansen, P., Vermeer, M.H., Marschalko, M., Papadavid, E., Piris, M.A., Ortiz‐Romero, P.L., Novelli, M., Paulli, M., Quaglino, P., Ranki, A., Rodríguez Peralto, J.L., Wobser, M., and Auschra, B.

Subjects
CUTANEOUS T-cell lymphoma, PROGNOSIS, ORGANIZATIONAL research, CANCER treatment, LYMPHOMAS, CANCER research
Abstract

Background: Cutaneous peripheral T‐cell lymphoma, not otherwise specified (PTL NOS) is an aggressive, but poorly characterized neoplasm. Objectives: The European Organization for Research and Treatment of Cancer cutaneous lymphoma taskforce (EORTC CLTF) investigated 33 biopsies of 30 patients with primary cutaneous PTL NOS to analyse their clinical, histological, immunophenotypic features and outcome. Methods: Retrospective analysis of clinical data and histopathological features by an expert panel. Results: Cutaneous PTL NOS manifested clinically either with solitary or disseminated rapidly grown ulcerated tumours or disseminated papulo‐nodular lesions. Histologically, a mostly diffuse or nodular infiltrate in the dermis and often extending into the subcutis was found. Epidermotropism was rarely present and only mild and focal. Unusual phenotypes were frequent, e.g. CD3+/CD4−/CD8− and CD3+/CD4+/CD8+. Moreover, 18% of the cases exhibited an aberrant expression of the B‐cell marker CD20 by the tumour cells. All solitary tumours were located on the limbs and presented a high expression of GATA‐3 but this did not correlate with outcome and therefore could not serve as a prognostic factor. The prognosis was shown to be generally poor with 10 of 30 patients (33%) dying of lymphoma within the follow‐up of 36 months (mean value; range 3–144). The survival rates were 61% after 3 years (CI, 43–85%) and 54% after 5 years (CI, 36–81%). Small to medium‐sized morphology of tumour cells was associated with a better outcome than medium to large or large tumour cells. Age, gender, clinical stage, CD4/CD8 phenotype and GATA‐3 expression were not associated with prognosis. Chemotherapy was the most common treatment modality, but surgical excision and/or radiotherapy may represent an appropriate first‐line treatment for solitary lesions. Conclusions: Cutaneous PTL NOS shows an aggressive course in most patients independent of initial presentation, age and phenotype. Cytomorphology was identified as a prognostic factor. The data indicate a need for more effective treatment modalities in PTL NOS. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Chromoblastomycosis: an autochthonous case of a tropical disease

Author

Calleja Algarra, A., primary, Prieto Barrios, M., additional, Manrique Multiozábal, A., additional, Alonso Moralejo, R., additional, Fradejas Villajos, I., additional, Pérez-Ayala, A., additional, López Medrano, F., additional, Rodríguez Peralto, J.L., additional, Ortiz Romero, P.L., additional, and Zarco Olivo, C., additional

Published
2018
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39. Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases

Author

Santos-Briz, A., primary, Calle, A., additional, Linos, K., additional, Semans, B., additional, Carlson, A., additional, Sangüeza, O.P., additional, Metze, D., additional, Cerroni, L., additional, Díaz-Recuero, J.L., additional, Alegría-Landa, V., additional, Mascaró, J.M., additional, Moreno, C., additional, Rodríguez-Peralto, J.L., additional, and Requena, L., additional

Published
2018
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41. Dermatopatología de la oclusión intraluminal vascular: parteII (coagulopatías, émbolos y miscelánea)

Author

Beato Merino, M.J., Diago, A., Fernandez-Flores, A., Fraga, J., García Herrera, A., Garrido, M., Idoate Gastearena, M.A., Llamas-Velasco, M., Monteagudo, C., Onrubia, J., Pérez-González, Y.C., Pérez Muñoz, N., Ríos-Martín, J.J., Ríos-Viñuela, E., Rodríguez Peralto, J.L., Rozas Muñoz, E., Sanmartín, O., Santonja, C., Santos-Briz, A., Saus, C., Suárez Peñaranda, J.M., and Velasco Benito, V.

Published
2021
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47. Tumor-infiltrating lymphocytes expression in stage IIIc/IV of high-grade serous ovarian cancer: Variation with neoadjuvant chemotherapy and prognostic value

Author

Bárcena, C., primary, Rojas, K., additional, Lema, L., additional, Manso Sánchez, L., additional, Rios, J., additional, García-Martín, R., additional, Maroto, A., additional, Rodríguez-Peralto, J.L., additional, Ciruelos Gil, E.M., additional, Mendiola, D.C., additional, and Paz-Ares, L., additional

Published
2017
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48. Cutaneous lymphoma international consortium study of outcome in advanced stages of mycosis fungoides and sézary syndrome: Effect of specific prognostic markers on survival and development of a prognostic model

Author

Scarisbrick, J.J. Prince, H.M. Vermeer, M.H. Quaglino, P. Horwitz, S. Porcu, P. Stadler, R. Wood, G.S. Beylot-Barry, M. Pham-Ledard, A. Foss, F. Girardi, M. Bagot, M. Michel, L. Battistella, M. Guitart, J. Kuzel, T.M. Martinez-Escala, M.E. Estrach, T. Papadavid, E. Antoniou, C. Rigopoulos, D. Nikolaou, V. Sugaya, M. Miyagaki, T. Gniadecki, R. Sanches, J.A. Cury-Martins, J. Miyashiro, D. Servitje, O. Muniesa, C. Berti, E. Onida, F. Corti, L. Hodak, E. Amitay-Laish, I. Ortiz-Romero, P.L. Rodríguez-Peralto, J.L. Knobler, R. Porkert, S. Bauer, W. Pimpinelli, N. Grandi, V. Cowan, R. Rook, A. Kim, E. Pileri, A. Patrizi, A. Pujol, R.M. Wong, H. Tyler, K. Stranzenbach, R. Querfeld, C. Fava, P. Maule, M. Willemze, R. Evison, F. Morris, S. Twigger, R. Talpur, R. Kim, J. Ognibene, G. Li, S. Tavallaee, M. Hoppe, R.T. Duvic, M. Whittaker, S.J. Kim, Y.H.

Abstract

Purpose: Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 to 5 years. Clinical management is stage based; however, there is wide range of outcome within stages. Published prognostic studies in MF/SS have been single-center trials. Because of the rarity of MF/SS, only a large collaboration would power a study to identify independent prognostic markers Patients and Methods: Literature review identified the following 10 candidate markers: stage, age, sex, cutaneous histologic features of folliculotropism, CD30 positivity, proliferation index, large-cell transformation, WBC/lymphocyte count, serum lactate dehydrogenase, and identical T-cell clone in blood and skin. Data were collected at specialist centers on patients diagnosed with advanced-stage MF/SS from 2007. Each parameter recorded at diagnosis was tested against overall survival (OS) Results: Staging data on 1,275 patients with advanced MF/SS from 29 international sites were included for survival analysis. The median OS was 63 months, with 2- and 5-year survival rates of 77% and 52%, respectively. The median OS for patients with stage IIB disease was 68 months, but patients diagnosed with stage III disease had slightly improved survival compared with patients with stage IB, although patients diagnosed with stage IV disease had significantly worse survival (48 months for stage IVA and 33 months for stage IVB). Of the 10 variables tested, four (stage IV, age > 60 years, large-cell transformation, and increased lactate dehydrogenase) were independent prognostic markers for a worse survival. Combining these four factors in a prognostic index model identified the following three risk groups across stages with significantly different 5-year surviva rates: low risk (68%), intermediate risk (44%), and high risk (28%) Conclusion: To our knowledge, this study includes the largest cohort of patients with advanced-stage MF/SS and identifies markers with independent prognostic value, which, used together in a prognostic ndex, may be useful to stratify advanced-stage patients. © 2015 by American Society of Clinical Oncology.

Published
2015

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