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313 results on '"Rodríguez-Patón, Alfonso"'

1. Applying Evolutionary Metaheuristics for Parameter Estimation of Individual-Based Models

Author

García, Antonio Prestes and Rodríguez-Patón, Alfonso

Subjects
Computer Science - Neural and Evolutionary Computing, Computer Science - Artificial Intelligence
Abstract

Individual-based models are complex and they have usually an elevated number of input parameters which must be tuned for reproducing the observed population data or the experimental results as accurately as possible. Thus, one of the weakest points of this modelling approach lies on the fact that rarely the modeler has the enough information about the correct values or even the acceptable range for the input parameters. Consequently, several parameter combinations must be tried to find an acceptable set of input factors minimizing the deviations of simulated and the reference dataset. In practice, most of times, it is computationally unfeasible to traverse the complete search space trying all every possible combination to find the best of set of parameters. That is precisely an instance of a combinatorial problem which is suitable for being solved by metaheuristics and evolutionary computation techniques. In this work, we introduce EvoPER, an R package for simplifying the parameter estimation using evolutionary computation methods.

Published
2020

7. An Implementation of Elementary Arithmetic with Virus Machine

Author

Yan, Xiaoshan, Liu, Xiangrong, Zeng, Xiangxiang, Rodríguez-Patón, Alfonso, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Graciani, Carmen, editor, Riscos-Núñez, Agustín, editor, Păun, Gheorghe, editor, Rozenberg, Grzegorz, editor, and Salomaa, Arto, editor

Published
2018
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8. A simple negative interaction in the positive transcriptional feedback of a single gene is sufficient to produce reliable oscillations

Author

Miró-Bueno, Jesús M. and Rodríguez-Patón, Alfonso

Subjects
Quantitative Biology - Molecular Networks, Quantitative Biology - Quantitative Methods
Abstract

Negative and positive transcriptional feedback loops are present in natural and synthetic genetic oscillators. A single gene with negative transcriptional feedback needs a time delay and sufficiently strong nonlinearity in the transmission of the feedback signal in order to produce biochemical rhythms. A single gene with only positive transcriptional feedback does not produce oscillations. Here, we demonstrate that this single-gene network in conjunction with a simple negative interaction can also easily produce rhythms. We examine a model comprised of two well-differentiated parts. The first is a positive feedback created by a protein that binds to the promoter of its own gene and activates the transcription. The second is a negative interaction in which a repressor molecule prevents this protein from binding to its promoter. A stochastic study shows that the system is robust to noise. A deterministic study identifies that the dynamics of the oscillator are mainly driven by two types of biomolecules: the protein, and the complex formed by the repressor and this protein. The main conclusion of this paper is that a simple and usual negative interaction, such as degradation, sequestration or inhibition, acting on the positive transcriptional feedback of a single gene is a sufficient condition to produce reliable oscillations. One gene is enough and the positive transcriptional feedback signal does not need to activate a second repressor gene. This means that at the genetic level an explicit negative feedback loop is not necessary. The model needs neither cooperative binding reactions nor the formation of protein multimers. Therefore, our findings could help to clarify the design principles of cellular clocks and constitute a new efficient tool for engineering synthetic genetic oscillators., Comment: 25 pages, 12 figures, 3 tables

Published
2011
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9. Will data analytics revolution finally bring SERS to the clinic?

Author

Mahmoud, Ahmed Y.F., primary, Teixeira, Alexandra, additional, Aranda, Marta, additional, Relvas, Maria S., additional, Quintero, Sergio, additional, Sousa-Silva, Maria, additional, Chícharo, Alexandre, additional, Chen, Mengkun, additional, Hashemi, Mohadeseh, additional, King, Jason B., additional, Tunnell, James W., additional, Morasso, Carlo, additional, Piccotti, Francesca, additional, Corsi, Fabio, additional, Henriksen-Lacey, Malou, additional, de Aberasturi, Dorleta Jimenez, additional, Merino, David Méndez, additional, Rodríguez-Patón, Alfonso, additional, Abalde-Cela, Sara, additional, and Diéguez, Lorena, additional

Published
2023
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10. Molecular Computing and Bioinformatics

Author

Zeng, Xiangxiang, Zou, Quan, and Rodríguez-Patón, Alfonso

Abstract

This text will provide the most recent knowledge and advances in the area of molecular computing and bioinformatics. Molecular computing and bioinformatics have a close relationship, paying attention to the same object but working towards different orientations. The articles will range from topics such as DNA computing and membrane computing to specific biomedical applications, including drug R&D and disease analysis.

Published
2019

19. Probabilistic Reasoning with an Enzyme-Driven DNA Device

Author

Sainz de Murieta, Iñaki, Rodríguez-Patón, Alfonso, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Soloveichik, David, editor, and Yurke, Bernard, editor

Published
2013
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20. Probabilistic Reasoning with a Bayesian DNA Device Based on Strand Displacement

Author

Sainz de Murieta, Iñaki, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Stefanovic, Darko, editor, and Turberfield, Andrew, editor

Published
2012
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21. Autonomous Resolution Based on DNA Strand Displacement

Author

Rodríguez-Patón, Alfonso, de Murieta, Iñaki Sainz, Sosík, Petr, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Cardelli, Luca, editor, and Shih, William, editor

Published
2011
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22. Simulating a Rock-Scissors-Paper Bacterial Game with a Discrete Cellular Automaton

Author

Gómez Esteban, Pablo, Rodríguez-Patón, Alfonso, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Ferrández, José Manuel, editor, Álvarez Sánchez, José Ramón, editor, de la Paz, Félix, editor, and Toledo, F. Javier, editor

Published
2011
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23. Polynomial Complexity Classes in Spiking Neural P Systems

Author

Sosík, Petr, Rodríguez-Patón, Alfonso, Ciencialová, Lucie, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Gheorghe, Marian, editor, Hinze, Thomas, editor, Păun, Gheorghe, editor, Rozenberg, Grzegorz, editor, and Salomaa, Arto, editor

Published
2011
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24. On the Power of Computing with Proteins on Membranes

Author

Sosík, Petr, Păun, Andrei, Rodríguez-Patón, Alfonso, Pérez, David, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Păun, Gheorghe, editor, Pérez-Jiménez, Mario J., editor, Riscos-Núñez, Agustín, editor, Rozenberg, Grzegorz, editor, and Salomaa, Arto, editor

Published
2010
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26. Sequentiality Induced by Spike Number in SNP Systems

Author

Ibarra, Oscar H., Păun, Andrei, Rodríguez-Patón, Alfonso, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goel, Ashish, editor, Simmel, Friedrich C., editor, and Sosík, Petr, editor

Published
2009
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27. A New Model of Synthetic Genetic Oscillator Based on Trans-Acting Repressor Ribozyme

Author

Bueno, Jesús M. Miró, Rodríguez-Patón, Alfonso, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Omatu, Sigeru, editor, Rocha, Miguel P., editor, Bravo, José, editor, Fernández, Florentino, editor, Corchado, Emilio, editor, Bustillo, Andrés, editor, and Corchado, Juan M., editor

Published
2009
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28. Effects of HIV-1 Proteins on the Fas-Mediated Apoptotic Signaling Cascade: A Computational Study of Latent CD4+ T Cell Activation

Author

Jack, John, Păun, Andrei, Rodríguez-Patón, Alfonso, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Corne, David Wolfe, editor, Frisco, Pierluigi, editor, Păun, Gheorghe, editor, Rozenberg, Grzegorz, editor, and Salomaa, Arto, editor

Published
2009
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29. An auxin-regulable oscillatory circuit drives the root clock in Arabidopsis

Author

Ministerio de Economía y Competitividad (España), European Commission, Comunidad de Madrid, Research Foundation - Flanders, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Perianez-Rodriguez, Juan [0000-0003-1002-7111], Rodriguez, Marcos [0000-0003-3741-8593], Marconi, Marco [0000-0002-3457-1384], Bustillo-Avendaño, Estefano [0000-0002-1442-8791], Wachsman, Guy [0000-0002-0551-9333], Sanchez-Corrionero, Alvaro [0000-0001-5360-0294], De Gernier, Hugues [0000-0002-7644-3233], Cabrera, Javier [0000-0002-9277-4876], Perez-Garcia, Pablo [0000-0001-8595-8530], Gude, Inmaculada [0000-0002-3122-1688], Saez, Angela [0000-0002-9189-4737], Serrano-Ron, Laura [0000-0001-5180-6547], Beeckman, Tom [0000-0001-8656-2060], Benfey, Philip N [0000-0001-5302-758X], Rodríguez-Patón, Alfonso [0000-0001-7289-2114], del Pozo, J. C. [0000-0002-4113-457X], Wabnik, Krzysztof [0000-0001-7263-0560], Moreno-Risueno, Miguel A [0000-0002-9794-1450], Perianez-Rodriguez, Juan, Rodriguez, Marcos, Marconi, Marco, Bustillo-Avendaño, Estefano, Wachsman, Guy, Sanchez-Corrionero, Alvaro, De Gernier, Hugues, Cabrera, Javier, Pérez-García, Pablo, Gude, Inmaculada, Saez, Angela, Serrano-Ron, Laura, Beeckman, Tom, Benfey, Philip N., Rodríguez-Patón, Alfonso, del Pozo, J. C., Wabnik, Krzysztof, Moreno-Risueño, Miguel Ángel, Ministerio de Economía y Competitividad (España), European Commission, Comunidad de Madrid, Research Foundation - Flanders, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Perianez-Rodriguez, Juan [0000-0003-1002-7111], Rodriguez, Marcos [0000-0003-3741-8593], Marconi, Marco [0000-0002-3457-1384], Bustillo-Avendaño, Estefano [0000-0002-1442-8791], Wachsman, Guy [0000-0002-0551-9333], Sanchez-Corrionero, Alvaro [0000-0001-5360-0294], De Gernier, Hugues [0000-0002-7644-3233], Cabrera, Javier [0000-0002-9277-4876], Perez-Garcia, Pablo [0000-0001-8595-8530], Gude, Inmaculada [0000-0002-3122-1688], Saez, Angela [0000-0002-9189-4737], Serrano-Ron, Laura [0000-0001-5180-6547], Beeckman, Tom [0000-0001-8656-2060], Benfey, Philip N [0000-0001-5302-758X], Rodríguez-Patón, Alfonso [0000-0001-7289-2114], del Pozo, J. C. [0000-0002-4113-457X], Wabnik, Krzysztof [0000-0001-7263-0560], Moreno-Risueno, Miguel A [0000-0002-9794-1450], Perianez-Rodriguez, Juan, Rodriguez, Marcos, Marconi, Marco, Bustillo-Avendaño, Estefano, Wachsman, Guy, Sanchez-Corrionero, Alvaro, De Gernier, Hugues, Cabrera, Javier, Pérez-García, Pablo, Gude, Inmaculada, Saez, Angela, Serrano-Ron, Laura, Beeckman, Tom, Benfey, Philip N., Rodríguez-Patón, Alfonso, del Pozo, J. C., Wabnik, Krzysztof, and Moreno-Risueño, Miguel Ángel

Abstract

In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the oscillator (AUXIN RESPONSE FACTOR 7, its auxin-sensitive inhibitor IAA18/POTENT, and auxin) that form a negative regulatory loop circuit in the oscillation zone. Through multilevel computer modeling fitted to experimental data, we explain how gene expression oscillations coordinate with cell division and growth to create the periodic pattern of organ spacing. Furthermore, gravistimulation experiments based on the model predictions show that external auxin stimuli can lead to entrainment of the root clock. Our work demonstrates the mechanism underlying a robust biological clock and how it can respond to external stimuli.

Published
2021

30. Hopcroft’s Minimization Technique: Queues or Stacks?

Author

Păun, Andrei, Păun, Mihaela, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ibarra, Oscar H., editor, and Ravikumar, Bala, editor

Published
2008
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31. Towards a Robust Biocomputing Solution of Intractable Problems

Author

García-Arnau, Marc, Manrique, Daniel, Rodríguez-Patón, Alfonso, Sosík, Petr, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Garzon, Max H., editor, and Yan, Hao, editor

Published
2008
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32. A Parallel DNA Algorithm Using a Microfluidic Device to Build Scheduling Grids

Author

García-Arnau, Marc, Manrique, Daniel, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Mira, José, editor, and Álvarez, José R., editor

Published
2007
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33. On Flip-Flop Membrane Systems with Proteins

Author

Păun, Andrei, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Eleftherakis, George, editor, Kefalas, Petros, editor, Păun, Gheorghe, editor, Rozenberg, Grzegorz, editor, and Salomaa, Arto, editor

Published
2007
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34. P Systems with Symport/Antiport and Time

Author

Nagda, Hitesh, Păun, Andrei, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Hoogeboom, Hendrik Jan, editor, Păun, Gheorghe, editor, Rozenberg, Grzegorz, editor, and Salomaa, Arto, editor

Published
2006
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35. P Systems with Active Membranes Characterize PSPACE

Author

Sosík, Petr, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Mao, Chengde, editor, and Yokomori, Takashi, editor

Published
2006
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36. Grammar Based Crossover Operator in Genetic Programming

Author

Manrique, Daniel, Márquez, Fernando, Ríos, Juan, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Mira, José, editor, and Álvarez, José R., editor

Published
2005
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40. Distributed Computing with Prokaryotic Immune Systems

Author

Murphy, Niall, Rodríguez-Patón, Alfonso, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Coello Coello, Carlos A., editor, Greensmith, Julie, editor, Krasnogor, Natalio, editor, Liò, Pietro, editor, Nicosia, Giuseppe, editor, and Pavone, Mario, editor

Published
2012
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41. MEGICO: An Intelligent Knowledge Management Methodology

Author

Maté, José Luis, Paradela, Luis Felipe, Pazos, Juan, Rodríguez-Patón, Alfonso, Silva, Andrés, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Gómez-Pérez, Asunción, editor, and Benjamins, V. Richard, editor

Published
2002
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48. Dynamical task switching in cellular computers

Author

Engineering and Physical Sciences Research Council (UK), Agencia Estatal de Investigación (España), European Commission, Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Ministerio de Ciencia y Tecnología (España), Ministerio de Ciencia, Innovación y Universidades (España), Goñi-Moreno, Ángel [0000-0002-2097-2507], Rodríguez-Patón, Alfonso [0000-0001-7289-2114], Goñi-Moreno, Ángel, Cruz, Fernando de la, Rodríguez-Patón, Alfonso, Amos, Martyn, Engineering and Physical Sciences Research Council (UK), Agencia Estatal de Investigación (España), European Commission, Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Ministerio de Ciencia y Tecnología (España), Ministerio de Ciencia, Innovación y Universidades (España), Goñi-Moreno, Ángel [0000-0002-2097-2507], Rodríguez-Patón, Alfonso [0000-0001-7289-2114], Goñi-Moreno, Ángel, Cruz, Fernando de la, Rodríguez-Patón, Alfonso, and Amos, Martyn

Abstract

We present a scheme for implementing a version of task switching in engineered bacteria, based on the manipulation of plasmid copy numbers. Our method allows for the embedding of multiple computations in a cellular population, whilst minimising resource usage inefficiency. We describe the results of computational simulations of our model, and discuss the potential for future work in this area.

Published
2019

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