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9. Gold Nanoparticles Synthesized by an Aqueous Extract of Codium tomentosum as Potential Antitumoral Enhancers of Gemcitabine.

Author

González-Ballesteros, Noelia, Maietta, Immacolata, Rey-Méndez, Raquel, Rodríguez-Argüelles, M. Carmen, Lastra-Valdor, Mariano, Cavazza, Antonella, Grimaldi, Maria, Bigi, Franca, and Simón-Vázquez, Rosana

Abstract

Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more active antitumoral agents. Furthermore, these natural extracts can be combined with nanotechnology to increase their efficacy and improve targeting. In this work, a Codium tomentosum (CT) aqueous extract was employed for the green synthesis of gold nanoparticles (Au@CT). The complete characterization of Au@CT was performed by UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Zeta potential, electron microscopy, X-ray powder diffraction (XRD), high-performance steric exclusion chromatography (HPSEC), and by the determination of their antioxidant capacity. The antiproliferative activity of Au@CT was then tested in hepatic (HEPG-2) and pancreatic (BxPC-3) cell lines. Their potential capacity as enhancers of gemcitabine, a drug frequently used to treat both types of tumors, was also tested. The activity of Au@CT was compared to the activity of the CT extract alone. A synergistic effect with gemcitabine was proven for HEPG-2. Our results showed that gold nanoparticles synthesized from seaweed extracts with antitumoral activity could be a good gemcitabine enhancer. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Corrigendum to “Macroalgae to nanoparticles: Study of Ulva lactuca L. role in biosynthesis of gold and silver nanoparticles and of their cytotoxicity on colon cancer cell lines” [Mater. Sci. Eng. C 97 (2019) 498–509]

Author

González-Ballesteros, Noelia, primary, Rodríguez-Argüelles, M. Carmen, additional, Prado-López, Sonia, additional, Lastra, Mariano, additional, Grimaldi, Maria, additional, Cavazza, Antonella, additional, Nasi, Lucia, additional, Salviati, Giancarlo, additional, and Bigi, Franca, additional

Published
2019
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13. Contributors

Author

Aachmann, Finn L., Aasen, Inga Marie, Aguilar, Cristóbal N., Aparicio, E., Bak, Urd Grandorf, Barriada, Jose L., Batool, Amna, Bedoux, Gilles, Bourgougnon, Nathalie, Carvalho, Duarte Nuno, Chye, Fook Yee, Cortès, Hugo Pliego, Critchley, Alan T., Daugbjerg-Christensen, Monica, Van Den Broek, Lambertus, Díaz-Reinoso, Beatriz, Dobruchowska, Justyna M., Fernández-Labrada, Miguel, Freile-Pelegrín, Yolanda, Fridjonsson, Olafur H., Garcia-Vaquero, Marco, Gomez, Laura, González-Ballesteros, Noelia, Goto, Motonobu, Gregersen, Olavur, Hansen, Steffen Cole Brandstrup, Hardouin, Kévin, Harmsen, Paulien, Herrero, Roberto, Hreggviðsson, Guðmundur Óli, Hurtado, Anicia Q., Illera-Vives, Marta, Inácio, Ana Rita, Kanda, Hideki, Karlsson, Eva Nordberg, Kostas, Emily T., Kraan, Stefan, Kristjansdottir, Thordis, Lange, Lene, Lara, Abraham, Laurens, Lieve M.L., Linares-Pastén, Javier, Lodeiro, Pablo, López-Mosquera, María Elvira, Loredo-Treviño, A., Machmudah, Siti, Maneein, Supattra, Martins, Margarida, Menaa, Farid, Meyer, Anne, Mikkelsen, Maria D., Milledge, John J., Moenaert, Antoine, Moreira, Ramón, Nelson, Robert S., Nordberg-Karlsson, Eva M., Padam, Birdie Scott, Peñuela, Ana, Rajauria, G., Reis, Rui L., Renuka, Remya Rajan, Robledo, Daniel, Rodríguez-Argüelles, M. Carmen, Rodriguez-Barro, Pilar, Rodríguez-Jasso, Rosa M., Ruiz, Héctor A., Santiago, Arufe, Sastre de Vicente, Manuel E., Sathyamoorthy, Gayathri, Seoane Labandeira, Socorro, Silva, Tiago H., Sletta, Håvard, Sousa, Rita O., Terme, Nolwenn, Thomsen, Marianne, Tiwari, Brijesh, Tøndervik, Anne, Ventura, Sónia P.M., Vilariño, Teresa, Wahyudiono, Yoganandham, Suman Thodhal, and Zhang, Xueqian

Published
2020
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