Search

Your search keyword '"Rodríguez, Romina"' showing total 146 results
Start Over Author "Rodríguez, Romina"
146 results on '"Rodríguez, Romina"'

3. Pasture type effects over beef quality: A comparison.

Author

Subiabre, Ignacio, Rodríguez, Romina A., Aldai, Noelia, Allende, Rodrigo, and Morales, Rodrigo

Subjects
*OMEGA-6 fatty acids, *UNSATURATED fatty acids, *BEEF quality, *ITALIAN ryegrass, *LOLIUM perenne
Abstract

The beef is one of the main sources of nutrients for a balanced diet. In this context, several authors have reported that grass-fed beef presents low levels of intramuscular fat and high levels of polyunsaturated fatty acids. Some studies have noted that forage fatty acid content is variable between species and their varieties, and that can affect fatty acid profile in beef. The aim of this study was to evaluate beef quality from three different types of pastures in southern Chile. A group of 45 Holstein Friesian steers were finished in the spring months with three different types of pastures from temperate rainy climate: Improved pasture (P), Lolium perenne L.-based pasture (LT), and Lolium multiflorum Lam.-based pasture (LM). The steers were separated into groups of 15 for treatment. Nonsignificant differences were found in carcass measurements and P treatment showed a higher intramuscular content than LM treatment (2.26% vs. 1.42%) and greater presence of SFA: 42.4% vs. 40.3% reported in LM treatment. While LM presented a higher n-6 fatty acids: 4.42% related to P treatment: 3.13%. Regardless of the type of pasture, it can be confirmed that meat from pasture systems presents low intramuscular fat and a better ratio of n-6/n-3. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Daily variation and repeatability of advertisement calls in an austral temperate forest frog under controlled conditions.

Author

Moreno‐Gómez, Felipe N., Bidart‐Enríquez, Gabriel, Cossio‐Rodríguez, Romina, Muñoz, Matías I., Quispe, Maricel, and Penna, Mario

Subjects
TEMPERATE forests, SEXUAL selection, STATISTICAL reliability, SOCIAL history, FROGS
Abstract

Estimating repeatability allows a first approximation that may indicate a potential response to selection of sexual traits. Acoustic sexual signals comprise spectral and temporal variables, where the former generally have lower intra‐individual variation and higher repeatability values. Studies of repeatability in anurans have been conducted mainly in natural conditions, but the stability of laboratory settings allows extended recording intervals, favoring measurement accuracy. We conducted a study of variation and repeatability of the calls of males of Batrachyla taeniata, a frog from the South American temperate forest to evaluate under homogeneous environmental and social conditions: (i) the extent of variation in acoustic properties of calls within and among days, (ii) the extent of temporal variation in the repeatability of call properties, and (iii) differences in repeatability among call variables. Variation of acoustic properties differed within and across days of recording, call rate generally increased within and throughout days, suggesting sensitization processes. Call duration decreased during these time spans, yielding constant calling effort. In contrast, the dominant frequency decreased within days but increased across days. Overall repeatability differs significantly among variables: dominant frequency, call rate, and call duration having the highest, intermediate, and lowest values, respectively. The high repeatability of call rate relative to call duration contrasts with an opposing general tendency in previous studies in anurans. The repeatability of the three variables analyzed increases within days, and the repeatability of call rate also increases throughout days, highlighting the relevance of this variable for individual identity over different time ranges. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Saturated Fatty Acids in Wool as Markers Related to Intramuscular Fat Content in Lambs.

Author

Inostroza, Karla, Larama, Giovanni, Díaz-Matus de la Parra, Mario, Bravo, Silvana, Rodríguez, Romina, Guerrero, Ana, and Cancino-Baier, David

Subjects
SATURATED fatty acids, NEAR infrared spectroscopy, MEAT quality, CONSUMER preferences, DISCRIMINANT analysis, ERECTOR spinae muscles
Abstract

Simple Summary: Intramuscular fat (IMF) is related to meat quality and consumer preferences. Several analytical methods involving solvents have been developed to determine IMF and are used to validate rapid and nondestructive new technologies, such as tomography, Raman spectroscopy and NIR. The current study assessed the fatty acid (FA) composition of wool and its relationship to IMF in the Longissimus lumborum muscle of lambs. Wool has the potential for non-invasive sampling, reflecting the animal's metabolism over the past 2 or 3 weeks, and can be stored for long periods of time. The results of this experiment suggest that saturated FA in wool could potentially be used to determine the IMF of lamb. The aim of this study was to identify Longissimus lumborum (LL) muscle from lambs with high IMF content (≥3%) using wool FA. The FA composition was characterized in two sections of wool from Suffolk Down lambs, and its relationship with IMF content assessed. One hundred and forty lambs of similar body weight, body condition score, and age were selected. IMF content from LL muscle, and the wool fat and FA composition of the wool were determined. The proportions of FAs in the wool of lambs with low IMF were 51.96 ± 7.3% of saturated, 31.96 ± 7.7% polyunsaturated, and 16.08 ± 2.3% monounsaturated. Similar proportions of FAs were observed in wool samples of lambs with high IMF. Significant differences were found only in the SFA proportion between groups (p < 0.05). The predominant FAs in the wool samples were C16:0, C17:0, C18:0, C18:1n9c and C18:2n6c, representing over 60% of total FA methyl esters. Correlations were found between the wool FAs C16:1, C17:0, C18:0, C18:1n9c, C24:0, and C22:6n3 in wool samples divided into two sections. Discriminant analysis identified SFAs, particularly FAs C22:0 and C24:0, as potential candidate for predicting lambs with high IMF content with an accuracy of over 92%. These results provide to our knowledge evidence that IMF content could potentially be determined using wool FAs as a non-invasive method. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Grape Seed Proanthocyanidin Extract Attenuates Cafeteria-Diet-Induced Liver Metabolic Disturbances in Rats: Influence of Photoperiod.

Author

Rodríguez, Romina M., Colom-Pellicer, Marina, Hernández-Baixauli, Julia, Calvo, Enrique, Suárez, Manuel, Arola-Arnal, Anna, Torres-Fuentes, Cristina, Aragonès, Gerard, and Mulero, Miquel

Subjects
*GRAPE seed extract, *RATS, *METABOLIC disorders, *WEIGHT gain, *BODY weight, *LIVER
Abstract

This study investigated the influence of photoperiod (day length) on the efficacy of grape seed proanthocyanidin extract (GSPE) in mitigating metabolic disorders in obese rats fed a cafeteria diet. Rats were exposed to standard (L12), long (L18), or short (L6) photoperiods and treated with GSPE or vehicle. In the standard photoperiod, GSPE reduced body weight gain (50.5%), total cholesterol (37%), and triglycerides (34.8%), while increasing the expression of hepatic metabolic genes. In the long photoperiod, GSPE tended to decrease body weight gain, increased testosterone levels (68.3%), decreased liver weight (12.4%), and decreased reverse serum amino acids. In the short photoperiod, GSPE reduced glycemia (~10%) and lowered triglyceride levels (38.5%), with effects modified by diet. The standard photoperiod showed the greatest efficacy against metabolic syndrome-associated diseases. The study showed how day length affects GSPE's benefits and underscores considering biological rhythms in metabolic disease therapies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor

Author

Pérez-Yanes, Silvia, primary, Lorenzo-Sánchez, Iria, additional, Cabrera-Rodríguez, Romina, additional, García-Luis, Jonay, additional, Trujillo-González, Rodrigo, additional, Estévez-Herrera, Judith, additional, and Valenzuela-Fernández, Agustín, additional

Published
2024
Full Text
View/download PDF

12. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Author

Dennis, Martin, Mead, Gillian, Forbes, John, Graham, Catriona, Hackett, Maree, Hankey, Graeme J, House, Allan, Lewis, Stephanie, Lundström, Erik, Sandercock, Peter, Innes, Karen, Williams, Carol, Drever, Jonathan, Mcgrath, Aileen, Deary, Ann, Fraser, Ruth, Anderson, Rosemary, Walker, Pauli, Perry, David, Mcgill, Connor, Buchanan, David, Chun, Yvonne, Dinsmore, Lynn, Maschauer, Emma, Barugh, Amanda, Mikhail, Shadia, Blair, Gordon, Hoeritzauer, Ingrid, Scott, Maggie, Fraser, Greig, Lawrence, Katherine, Shaw, Alison, Williamson, Judith, Burgess, David, Macleod, Malcolm, Morales, Dan, Sullivan, Frank, Brady, Marian, French, Ray, Van Wijck, Frederike, Watkins, Caroline, Proudfoot, Fiona, Skwarski, Joanna, Mcgowan, Diane, Murphy, Rachael, Burgess, Seona, Rutherford, William, Mccormick, Katrina, Buchan, Ruaridh, Macraild, Allan, Paulton, Ruth, Fazal, Adnan, Taylor, Pat, Parakramawansha, Ruwan, Hunter, Neil, Perry, Jack, Bamford, John, Waugh, Dean, Veraque, Emelda, Bedford, Caroline, Kambafwile, Mary, Idrovo, Luis, Makawa, Linetty, Smalley, Paula, Randall, Marc, Thirugnana-Chandran, Tharani, Hassan, Ahamad, Vowden, Richard, Jackson, Joanne, Bhalla, Ajay, Rudd, Anthony, Tam, Chi Kai, Birns, Jonathan, Gibbs, Charlotte, Lee Carbon, Leonie, Cattermole, Elizabeth, Marks, Katherine, Cape, Angela, Hurley, Lisa, Kullane, Sagal, Smyth, Nigel, Eglinton, Charlotte, Wilson, Jennifer, Giallombardo, Elio, Frith, Angela, Reidy, Paul, Pitt, Matthew, Sykes, Lucy, Dellafera, Deborah, Croome, Victoria, Kerwood, Lauriane, Hancevic, Mirea, Narh, Christina, Merritt, Carley, Duffy, John, Cooke, Duncan, Willson, Juliet, Ali, Ali, Naqvi, Aaizza, Kamara, Christine, Bowler, Helen, Bell, Simon, Jackson, Tracy, Harkness, Kirsty, Stocks, Kathy, Duty, Suzanna, Doyle, Clare, Dunn, Geoffrey, Endean, Keith, Claydon, Fiona, Richards, Emma, Howe, Jo, Lindert, Ralf, Majid, Arshad, Dakin, Katy, Maatouk, Ahmad, Barron, Luke, Meegada, Madana, Rana, Pratap, Nair, Anand, Brighouse-Johnson, Christine, Greig, Jill, Kyu, Myint, Prasad, Sanjeev, Robinson, Matthew, Alam, Irfan, Mclean, Belinda, Greenhalgh, Lindsay, Ahmed, Zenab, Roffe, Christine, Brammer, Susan, Beardmore, Carole, Finney, Kay, Barry, Adrian, Hollinshead, Paul, Grocott, Jeanette, Maguire, Holly, Natarajan, Indira, Chembala, Jayan, Sanyal, Ranjan, Lijko, Sue, Abano, Nenette, Remegoso, Alda, Ferdinand, Phillip, Stevens, Stephanie, Varquez, Resti, Causley, Chelsea, Butler, Adrian, Whitmore, Philip, Stephen, Caroline, Carpio, Racquel, Hiden, Joanne, Muddegowda, Girish, Denic, Hayley, Sword, Jane, Curwen, Ross, James, Martin, Mudd, Paul, Hall, Fiona, Cageao, Julie, Keenan, Samantha, Roughan, Caroline, Kingwell, Hayley, Hemsley, Anthony, Lohan, Christoph, Davenport, Sue, Bowring, Angela, Chapter, Tamika, Hough, Max, Strain, David, Gupwell, Karin, Miller, Keniesha, Goff, Anita, Cusack, Ellie, Todd, Shirley, Partridge, Rebecca, Jennings, Georgiana, Thorpe, Kevin, Stephenson, Jacquelyn, Littlewood, Kelly, Barber, Mark, Brodie, Fiona, Marshall, Steven, Esson, Derek, Coburn, Irene, Mcinnes, Caroline, Ross, Fiona, Bowie, Emma, Barcroft, Heather, Withers, Victoria, Miller, Laura, Willcoxson, Paul, Donninson, Michelle, Evans, Richard, Daniel, Di, Coyle, John, Keeling, Michael, Wanklyn, Peter, Elliott, Mark, Wightman, John, Iveson, Elizabeth, Dyer, Natasha, Porteous, Anne-Marie, Haritakis, Monica, Ward, Mandy, Doughty, Lucy, Carr, Lisa, O Neill, Mark, Anazodo, Cosmas, Wood, Paul, Cottrell, Poppy, Donne, Cheryl, Rodriguez, Romina, Mir, Ruhail, Westmoreland, Jax, Bell, Judith, Emms, Christopher, Wright, Lorraine, Clark Brown, Pearl, Bamford, Elizabeth, Stanners, Andrew, Carpenter, Mike, Datta, Prabal, Davey, Richard, Needle, Ann, Eastwood, Marjorie Jane, Razik, Fathima Zeena, Ghouri, Imran, Bateman, Gavin, Archer, Judy, Balasubramanian, Venkatesh, Bowers, Richard, Ball, Julie, Benton, Louise, Jackson, Linda, Ellam, Julie, Norton, Kate, Guyler, Paul, Dowling, Terry, Tysoe, Sharon, Harman, Paula, Kundu, Ashish, Omodunbi, Ololade, Loganathan, Thayalini, Chandler, Stuart, Noor, Shanas, Siddiqui, Anwer, Siddiqui, Amber, Kunhunny, Swapna, Sinha, Devesh, Sheppard, Martin, Rashmi, Sindhu, France, Elena, Orath Prabakaran, Rajalakshmi, Wilson, Laura, Ropun, Amiirah, Kelavkar, Shyam, Ng, Kheng Xiong, Kamuriwo, Lucy, Shah, Sweni, Mangion, David, Constantin, Camen, De Michele Hock, Luigi, Hardwick, Anne, Borley, Jayne, Markova, Skarlet, Netherton, Kimberley, Lawrence, Tara, Fletcher, Jo, Spencer, Rebecca, Palmer, Helen, Cullen, Claire, Hamill, Dolores, Durairaj, Ramesh, Mellor, Zoe, Fluskey, Tanya, Wood, Diane, Keeling, Alison, Hankin, Victoria, Peters, Jennifer, Shackcloth, Daniela, Hlaing, Thant, Tangney, Rebecca, Ewing, Jordan, Harrison, Melanie, Stevenson, Sarah, Sutton, Victoria, Soliman, Mohamed, Hindle, Julia, Watson, Elizabeth, Hewitt, Claire, Butler, Susie, Wahishi, Ibrahim, Arif, Sarwat, Fields, Amy, Sharma, Jagdish, Brown, Rose, Taylor, Caroline, Bell, Sarah, Leach, Simon, Patterson, Chris, Khan, Sophia, Wilson, Helen, Price, Joanne, Ramadan, Hawraman, Maguire, Stuart, Bellfield, Ruth, Hooley, Michaela, Hamid, Umair, Gaba, Waqar, Ghulam, Robina, Masters, Leslie, Quinn, Outi, Sekaran, Lakshmanan, Tate, Margaret, Mohammed, Niaz, Bharaj, Kiranjit, Justin, Frances, Pattni, Rajan, Alwis, Lanka, Sethuraman, Sakthivel, Robinson, Rianne, Eldridge, Lianne, Mintias, Susan, Chauhan, Meena, Tam, Chi-Kai, Palmones, Jeremias, Holmes, Clare, Guthrie, Lucy Belle, Osborn, Mairead, Ball, Lindsay, Caine, Sarah, Steele, Amy, Murphy, Peter, Devitt, Nikki, Leonard, Jayne, Patel, Ronak, Penwarden, Ian, Dodd, Emily, Holloway, Amy, Baker, Pauline, Clarke, Samantha, Williams, Sandra, Dow, Lindsey, Wynn-Williams, Roland, Kennedy, James, Teal, Rachel, Schulz, Ursula, Ford, Gary, Mathieson, Philip, Reckless, Ian, Deveciana, Ana, Mccann, Paige, Cluckie, Gillian, Howell, Geoffrey, Ayer, Jonathan, Moynihan, Barry, Ghatala, Rita, Clarke, Brian, Cloud, Geoffrey, Patel, Bhavini, Khan, Usman, Al-Samarrai, Nia, Trippier, Sarah, Chopra, Neha, Adedoyin, Temi, Watson, Fran, Jones, Val, Zhang, Liqun, Choy, Lillian, Williams, Rebecca, Clarke, Natasha, Blight, Adrian, Kennedy, Kate, Dainty, Alice, Selvarajah, Johann, Kalladka, Dheeraj, Cheripelli, Bharath, Smith, Wilma, Moreton, Fiona, Welch, Angela, Huang, Xuya, Douglas, Elizabeth, Lush, Audrey, Day, Nicola, El Tawil, Salwa, Montgomery, Karen, Hamilton, Helen, Ritchie, Doreen, Ramachandra, Sankaranarayanan, Mcleish, Kirsty, Thavanesan, Kamy, Loganathan, Sathyabama, Roberts, Josh, Cox, Chantel, Orr, Sarah, Hogan, Alison, Tiwari, Divya, Hann, Gail, Longland, Barbara, David, Owen, Bell, Jo, Ovington, Catherine, Rogers, Emily, Bower, Rachel, Keltos, Marketa, Cohen, David, Devine, Joseph, Alwis, Lankantha, Southworth, Lucy, Burgess, Laura, Lang, Matilda, Badiani, Bhavna, Guo, Fenglin, Oshodi, Anne, Owoyele, Emmanuelle, Epie, Norah, David, Anette, Mpelembue, Mushiya, Bathula, Rajaram, Abdul-Saheb, Mudhar, Chamberlain, Angela, Sudkeo, Varthi, Rashed, Khalid, Williams-Yesson, Barbara, Board, Joanne, De Bruijn, Sarah, Buckley, Clare, Board, Sarah, Allison, Joanna, Keeling, Elizabeth, Duckett, Tracey, Donaldson, Dave, Vickers, Carinna, Barron, Claire, Balian, Linda, Wilson, Jodhi, Edwards, Adam, England, Timothy, Hedstrom, Amanda, Bedford, Elizabeth, Harper, Margaret, Melikyan, Elina, Abbott, Wendy, Subramanian, Kashmira, Goldsworthy, Marie, Srinivasan, Meena, Yeomans, Angela, Donaldson, Denise, Hurford, Frances, Chapman, Riquella, Shahzad, Sana, Motherwell, Nicki, Tonks, Louise, Young, Rachel, Ghani, Usman, Mukherjee, Indranil, Dutta, Dipankar, Obaid, Mudhar, Brown, Pauline, Davis, Fiona, Ward, Deborah, Turfrey, Jennifer, Cartwright, Bethan, Topia, Bilal, Spurway, Judith, Collins, Kayleigh, Bakawala, Rehana, Hughes, Chloe, Oconnell, Susan, Hill, Linda, Chatterjee, Kausik, Webster, Tim, Haider, Syed, Rushworth, Pamela, Macleod, Fiona, Nallasivan, Arumugam, Perkins, Charlotte, Burns, Edel, Leason, Sandra, Carter, Tom, Seagrave, Samantha, Sami, Eman, Armstrong, Lisa, Naqvi, Syed Naseem, Hassan, Muhammad, Parkinson, Sharron, Mawer, Samantha, Darnbrook, Gillian, Booth, Carl, Hairsine, Brigid, Smith, Matthew, Williamson, Sue, Farquhar, Fiona, Esisi, Bernard, Cassidy, Tim, Mankin, Gavin, Mcclelland, Beverley, Bokhari, Maria, Sproates, David, Epstein, Elliot, Hurdowar, Steve, Blackburn, Ruth, Sukhdeep, Nazran, Razak, Saika, Osman, Khalid, Hashmi, Amina, Upton, Natasha, Harrington, Frances, Courtauld, Gillian, Schofield, Christine, Lucas, Linda, Adie, Katja, Bond, Kirsty, Mate, Abhijit, Skewes, Jo, James, Ali, Brodie, Carolyn, Johnson, Matthew, Allsop, Linda, Driver, Emma, Harris, Karina, Drake, Mark, Ellis, Sam, Maund, Bev, Thomas, Emma, Moore, Kimberley, Burn, Matthew, Hamilton, Adam, Mahalingam, Shageetha, Misra, Amulya, Reid, Farrah, Benford, Adrienne, Hilton, Derek, Hazell, Lorraine, Ofori, Keziah, Thomas, Anne Louise, Mathew, Moncy, Dayal, Sonia, Burn, Iona, Fotherby, Kenneth, Jennings-Preece, Karla, Willberry, Angela, Morgan, Debbie, Butler, Donna, Sahota, Gurminder, Kauldhar, Kelly, Ahmad, Nasar, Stevens, Angela, Das, Saugata, Bruce, David, Pai, Yogish, Nyo, Khin, Stephenson, Lynsey, Nendick, Richard, Rogers, Gill, Dhakal, Mahesh, Dima, Sofia, Brown, Ellen, Clayton, Susan, Gamble, Penny, Naeem, Muhammad, Hayman, Rachel, Burnip, Rachel, Earnshaw, Philip, Hargroves, David, Ransom, Barbara, Rudenko, Hannah, Balogun, Ibrahim, Griffiths, Kirsty, Mears, Kim, Webb, Tom, Cowie, Linda, Hammond, Tessa, Thomson, Audrey, Ceccarelli, Daniela, Chattha, Navraj, Beranova, Eva, Verrion, Anna, Gillian, Andrew, Schumacher, Natasha, Bahk, Anna, Walker, Susannah, Cvoro, Vera, Chapman, Nicola, Pound, Susan, Cain, Rebecca, Mcauley, Sean, Couser, Mandy, Simpson, Maria, Tachtatzis, Athan, Ullah, Khalil, Sims, Don, Jones, Rachael, Smith, Jonathan, Tongue, Rebecca, Willmot, Mark, Sutton, Claire, Littleton, Edward, Khaira, Jattinder, Maiden, Susan, Cunningham, James, Green, Carole, Chin, Yin-May, Bates, Michelle, Ahlquist, Katherine, Kane, Ingrid, Breeds, Joanna, Sargent, Tenesa, Latter, Laura, Pitt Ford, Alexandra, Gainsborough, Nicola, Levett, Tom, Thompson, Philip, Barbon, Emma, Dunne, Angela, Hervey, Simon, Ragab, Suzanne, Sandell, Tracy, Dickson, Christine, Dube, Judith, Power, Sharon, Evans, Nick, Wadams, Beverley, Elitova, Savina, Aubrey, Beth, Garcia, Tatiana, Mcilmoyle, James, Jeffs, Carol, Dickinson, Christina, Ahmed, Anis, Kumar, Sanjeev, Frudd, Julie, Armer, Charlotte, Potter, Andrew, Donaldson, Stacey, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Collas, David, Sundayi, Saul, Denham, Lynn, Oza, Deepali, Walker, Elaine, Bhandari, Mohit, Ispoglou, Sissy, Evans, Rachel, Sharobeem, Kamel, Walton, Elaine, Shanu, Steven, Hayes, Anne, Howard-Brown, Jennifer, Billingham, Steven, Weir, Nic, Pressly, Vanessa, Wood, Emma, Howard, Gabriella, Burton, Holly, Crawford, Pam, Egerton, Shuna, Evans, Sue, Hakkak, Jasmine, Andrews, Janet, Lampard, Rebecca, Allen, Christopher, Walters, Ashleigh, Said, Rasha, Marigold, James Richard, Tsang, Sau-Mon, Creeden, Robyn, Cox, Chloe, Smith, Simon, Gartrell, Imogen, Smith, Fiona, Jenkins, Colin, Pryor, Joanna, Hedges, Andrew, Price, Fiona, Moseley, Linda, Mercer, Lily, Hughes, Claire, Azim, Abul, White, Julie, Krasinska-Chavez, Milena, Chaplin, Shaun, Curtis, James, Singh, Deepwant, Imam, Javed, Nicolson, Anne, Alam, Sajid, Whitworth, Simon, Wood, Lisa, Warburton, Elizabeth, Kelly, Siobhan, Mcgee, Joanne, Markus, Hugh, Chandrasena, Denish, Hayden, Derek, Sesay, Juliana, Hayhoe, Helen, Bolton, Mark, Macdonald, Jane, Mitchell, Jenny, Farron, Charlotte, Amis, Elaine, Day, Diana, Culbert, Ainsley, Espanol, Ailene, Hannon, Niamh, Handley, Dominic, Finlay, Sarah, Crisp, Sarah, Whitehead, Lynne, Francis, Jobbin, Oconnell, Janice, Osborne, Emily, Beard, Rod, Krishnamurthy, Ramesh, Mokoena, Langanani, Sattar, Naweed, Myint, Min, Edwards, Michelle, Smith, Andrew, Corrigan, Paul, Byrne, Anthony, Blackburn, Joanne, Mcghee, Caroline, Smart, Amanda, Donaldson, Fiona, Copeland, Claire, Wilson, Jill, Scott, Rhona, Fitzsimmons, Paul, Lopez, Paula, Wilkinson, Mark, Manoj, Aravindakshan, Cox, Penelope, Trainor, Leona, Fletcher, Glyn, Denny, Lisa, Kavanagh, Karen, Allsop, Hannah, Emsley, Hedley, Sultan, Sulaiman, Mcloughlin, Alison, Walmsley, Benjamin, Hough, Louise, Ahmed, Shakeel, Doyle, Donna, Gregary, Bindu, Raj, Sonia, Nagaratnam, Kirubananthan, Mannava, Neelima, Haque, Nyla, Shields, Norma, Preston, Kate, Mason, Geraldine, Short, Kirsty, Lumsdale, Gemma, Uitenbosch, Giulia, Sukys, Ugnius, Valentine, Stacey, Jarrett, David, Dodsworth, Kerry, Wands, Mary, Khan, Nisa, Tandy, Jane, Watkinson, Catrin, Golding, Wendy, Butler, Rebecca, Williams, Max, Davies, Yasmin, Yip, Keith, James, Claire, Suttling, Anne, Maney, Aditya, Gamble, Giles Edward, Hague, Adam, Charles, Bethan, Blane, Sujata, Duran, Beatriz, Lambert, Caroline, Stagg, Katherine, Whiting, Robert, Homan, Jane E, Brown, Sarah, Hussain, Malik, Harvey, Miriam, Graham, Libby, Foote, Leanne, Lane, Catherine, Kemp, Liz (Joan), Rowe, Joy, Durman, Helen, Foot, Jayne, Brotherton, Lucy, Hunt, Nicholas, Pawley, Corinne, Whitcher, Alison, Sutton, Patrick, Mcdonald, Susan, Pak, Denys, Wiltshire, Alison, Jagger, Jennifer, Metcalf, Anthony K, Healey, Gail Louise, Balami, Joyce, Self, Clare Marie, Crofts, Melissa, Chakrabarti, Annie, Hmu, Chit, Ravenhill, Garth, Grimmer, Charmaine, Soe, Thandar, Keshet-Price, Jocelyn, Langley, Margaret, Potter, Ian, Tam, Pui-Lin, Macleod, Mary Joan, Cooper, Patricia, Christie, Michael, Irvine, Janice, Annison, Faye, Christie, David, Meneses, Celia, Johnson, Amber, Joyson, Anu, Nelson, Sandra, Taylor, Vicky, Reid, John, Clarke, Rebecca, Furnace, Jacqueline, Gow, Heather, Abousleiman, Youssif, Beadling, Tania, Collins, Sally, Jones, Stuart, Purcell, Jessica, Bloom, Samantha, Goshawk, Shelly, Landicho, Marcial, Sangaralingham, Sivatharshini, Begum, Yasmin, Mutton, Sherree, Munuswamy Vaiyapuri, Elangovan, Allen, Jane, Lowe, Jemma, Hughes, Martin, Wiggam, Ivan, Cuddy, Sarah, Tauro, Suzanne, Wells, Brian, Mohd Nor, Azlisham, Persad, Nicola, Kalita, Maggie, Weatherby, Stuart, Brown, Claire, Pace, Adrian, Lashley, Daniel, Marner, Mike, Weinling, Marie, Wilmshurst, Natasha, Waugh, Darren, Mucha, Anna, Shah, Alex, Baker, John, Westcott, Jacqueline, Cowan, Richard, Vasileiadis, Evangelos, Mumani, Samira, Parry, Anthea, Mason, Cathy, Holden, Melinda, Petrides, Katerina, Nishiyama, Tomoko, Mehta, Hina, Krishnan, Manju, Lynne, Dacey, Thomas, Lisa, Lynda, Connor, Hughes, Catherine, Clements, Clare, Williams, Rhys, Anjum, Tal, Sharon, Storton, Tucker, Susan, Jones, Paul, Colwill, Deanne, Thompson Jones, Helen, Chadha, Dinesh, Fairweather, Mark, Walstow, Deborah, Fong, Rosanna, Johnston, Stuart, Almadenboyle, Christine, Ross, Sarah, Carson, Shona, Nair, Priya, Tenbruck, Emily, Stirling, Mairi, Pusalkar, Aparna, Beadle, Hannah, Chan, Kelly, Dangri, Puneet, Asokanathan, Asaipillai, Rana, Anita, Gohil, Sunita, Massyn, Mark, Aruldoss, Prabhu, Cook, Angela, Crabtree, Karen, Dabbagh, Sura, Black, Toby, Clarke, Caroline, Mead, Denise, Fennelly, Ruth, Anthony, Alpha, Nardone, Linda, Dimartino, Victoria, Tribbeck, Michele, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Skotnicka, Agnieszka, Thompson, Jane, Whitehouse, Sarah, Sigsworth, Andrew, Wong, Jason, Annamalai, Arunkumar, Pagan, Julie, Affley, Brendan, Sunderland, Caroline, Goldenberg, Lynda, Khan, Atif, Wilkinson, Peter, Nari, Raad, Abbott, Lucy, Young, Emma, Shakhon, Amritpal, Lock, Sally, Stewart, Jack, Pereira, Rita, Dsouza, Margaret, Dunn, Sally, Mckenna, Anne-Marie, Cron, Nina, Kidd, Michelle, Hull, Grace, Bunworth, Kerry, Drummond, Graham, Mahawish, Karim, Hayes, Nicola, Connell, Lynne, Simpson, Jennifer, Penney, Helen, Punekar, Shuja, Nevinson, Joanne, Wareing, William, Ward, Jacqueline, Greenwood, Richard, Austin, Duncan, Banaras, Azra, Hogan, Carolin, Corbett, Thomas, Oji, Nnebuife, Elliott, Emma, Brezitski, Maria, Passeron, Nathalie, Howaniec, Laura, Watchurst, Caroline, Patel, Krishna, Erande, Renuka, Shah, Rahi, Sengupta, Nabarun, Metiu, Maria, Gonzalez, Celia, Funnell, Sarah, Margalef, Jordi, Peters, Gillian, Chadbourn, Indra, Sivakumar, Ramachandran, Saksena, Rajesh, Ketley-O'donel, Jane, Needle, Richard, Chinery, Elaine, Wright, Alison, Cook, Sue, Ngeh, Joseph, Proeschel, Harald, Cook, Paige, Ashcroft, Pauline, Sharpe, Simon, Jones, Stephanie, Jenkinson, Damian, Kelly, Deborah, Bray, Holly, Gunathilagan, Gunaratnam, Jones, Sally, Tilbey, Sorrell, Abubakar, Saidu, Vassallo, Joseph, Leonard, Dee, Orrell, Lucy, Hasan, Aziz, Khan, Asif, Qamar, Sulmaaz, Graham, Susan, Hewitt, Emma, Awolesi, Jennifer, Haque, Muhammad, Kent, Alissa, Bradshaw, Elizabeth, Cooper, Martin, Wynter, Inez, Rajapakse, Anoja, Janbieh, Joumana, Nasar, Abu M, Wade, Lynne, Otter, Linda, Haigh, Steve, Burgoyne, Jamie-Rae, Boulton, Rebecca, Boulton, Andrew, Rayessa, Rayessa, Clarkson, Emma, Rhian, Horne, Fleming, Amy, Mitchelson, Kim, Lowthorpe, Vicki, Abdul-Hamid, Ahmed, Jones, Phil, Duggan, Claire, Hynes, Abigail, Nurse, Emma, Raza, Syed Abid, Jones, Sarah, Pallikona, Udaya, Edwards, Bleddyn, Morgan, Geraint, Dennett, Kirsty, Tench, Helen, Loosley, Ronda, Trugeon-Smith, Toby, Jones, Rhian, Williams, Richard, Robson, Donna, Mavinamane, Sunanda, Meenakshisundaram, Sanjeevi, Ranga, Lalitha, Dealing, Sharon, Hill, Andrew, Hargreaves, Margaret, Smith, Tom, Bate, Julie, Harrison, Linda, Kirthivasan, Ramanathan, Cannon, Emma, Topliffe, Joanne, Keskeys, Rebecca, Williams, Sarah, Mcneela, Fiona, Cairns, Frances, James, Thomas, Lyle, Amanda, Shah, Sheela, Zachariah, George, Fergey, Lauren, Smolen, Susan, Cooper, Lucy, Bohannan, Elizabeth, Omer, Siddiq, Amlani, Sageet, Hunter, Nadia, Hawkes-Blackburn, Melissa, Gulli, Giosue, Peacocke, Alice, Amero, Justine, Burova, Maria, Speirs, Ottilia, Levy, Steph, Francis, Lynda, Holland, Susan, Brotheridge, Sean, Lyon, Helen, Hare, Christine, Jackson, Samantha, Stephenson, Lorraine, Al Hussayni, Samer, Featherstone, James, Bwalya, Agness, Singh, Arun, Goorah, M N, Walford, Jamie, Bell, Angela, Kelly, Christine, Rusk, Darren, Sutton, Deborah, Patel, Farzana, Duberley, Stephen, Hayes, Kathryn, Hunt, Lorraine, El Nour, Ahmed, Honour, Sacha, Box, Chloe, Dyer, Simon, Brown, Lynne, Elliott, Kerry, Temlett, Emma, Paterson, John, Furness, Rosie, Young, Shelli, Orugun, Enoch, Brewer, Chris, Thornthwaite, Sarah, Crowther, Hannah, Glover, Rachel, Sein, Moe, Haque, Kashif, Gibson, Elspeth, Wong, Sam, Rotchell, Karen, Burton, Karen, Brookes, Lisa, Bailey, Linda, Lindley, Chris, Murray, Abbi, Waltho, Karen, Holland, Maureen, Kumar, Pradeep, Harlekar, Purnima, Booth, Laura, Culmsee, Charlotte, Drew, Jade, Khan, Mohammad, Mackenzie, Nicola, Thomas, Carmel, Ritchie, Jane, Barker, James, Haley, Michael, Cotterill, Donna, Lane, Lynne, Little, Christine, Simmons, Dawn, Saunders, Glenn, Dymond, Harvey, Kidd, Sarah, Warinton, Rachel, Neves-Silva, Yara, Nevajda, Branimir, Villaruel, Michael, Umasankar, Udayaraj, Patel, Seema, Man, Anna, Christmas, Natasha, Rangasamy, Ravi, Ladner, Richard, Butt, Georgina, Alvares, Wilson, Gadi, Narasimha, Power, Michael, Wroath, Belinda, Dynan, Kevin, Wilson, David, Crothers, Sarah, Leonard, Catherine, Hagan, Samantha, Douris, Geraldine, Vahidassr, Djamil, Thompson, Alastair, Gallen, Brian, Mckenna, Shirley, Edwards, Collette, Mcgoldrick, Clare, Bhattad, Murdi, Kawafi, Khalil, Morse, Deborah, Jacob, Patricia, Turner, Lisa, Saravanan, Narayanamoorti, Johnson, Linda, Humphrey, Sadie, Namushi, Robert, Patel, Ramesh, Mclaughlin, Jemma, Omahony, Paul, Osikominu, Esther, Orefo, Chukwuka, Mcdonald, Chisha, Makanju, Esther, Khan, Tabindah, Appiatse, Grace, Stone, Helena, Augustin, Martia, Wardale, Alicia, Salehin, Maqsud, Bailey, Duncan, Garcia-Alen, Luciano, Kalathil, Latheef, Tinsley, Sarah, Jones, Taya, Amor, Kelly, Ritchings, Andrew, Margerum, Emma, Horton, Jane, Miller, Richard, Gautam, Nireekshana, Meir, Julie, Jones, Amaryl, Putteril, Janet, Lepore, Mirella, Gallifent, Rachel, Arundell, Laura-Louise, Mcredmond, Catherine, Goulding, Alicia, Nadarajan, Vivek, Laurence, Julia, Fung Lo, Su, Melander, Sabina, Nicholas, Paul, Woodford, Elizabeth, Mckenzie, Gillian, Le, Vietland, Crause, Jacolene, Luder, Robert, Bhargava, Maneesh, Bhome, Girish, Johnson, Venetia V, Chesser, Dara, Bridger, Hayley, Murali, Elodie, Scott, Jon, Morrison, Susan, Burns, Amy, Graham, Julie, Duffy, Madeline, Ali, Khalid, Pitcher, Emma, Gaylard, Jane, Newman, Julie, Punnoose, Sunil, Besley, Sarah, Purohit, Kirtan, Rees, Amy, Davy, Mark, Chohan, Osman, Khan, Muhammad Fozan, Walker, Rachel, Murray, Vicky, Bent, Charlotte, Oakley, Susan, Peixoto, Cassilda, Jones, Suzanne, Livingstone, Gaybrielle, Butler, Fiona, Bradfield, Sally, Gordon, Laura, Schmit, Jenneke, Wijewardane, Anika, Edmunds, Tineke, Wills, Rebecca, Medcalf, Catherine, Argandona, Lucia, Cuenoud, Larissa, Hassan, Hanna, Erumere, Esther, Ocallaghan, Aidan, Gompertz, Patrick, Redjep, Ozlem, Auld, Grace, Song, Anna, Tarkas, Tillana, Kabash, Hashim, and Hungwe, Rumbi

Published
2019
Full Text
View/download PDF

14. En tránsito por el norte de Chile: Desplazamiento forzado de población venezolana bajo el control fronterizo y sanitario durante la pandemia por COVID‐19 (2020‐2021).

Author

Liberona Concha, Nanette, Rodríguez, Romina Ramos, Rivera, Carlos Piñones, and Ramírez, Marioly Corona

Subjects
COVID-19, COVID-19 pandemic, POLITICAL refugees, MILITARISM, ETHNOLOGY, INTERGENERATIONAL mobility
Abstract

Copyright of Journal of Latin American & Caribbean Anthropology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
Full Text
View/download PDF

21. HIV-1 envelope glycoproteins isolated from Viremic Non-Progressor individuals are fully functional and cytopathic

Author

Cabrera-Rodríguez, Romina, Hebmann, Veronique, Marfil, Silvia, Pernas, María, Marrero-Hernández, Sara, Cabrera, Cecilia, Urrea, Victor, Casado, Concepción, Olivares, Isabel, Márquez-Arce, Daniel, Pérez-Yanes, Silvia, Estévez-Herrera, Judith, Clotet, Bonaventura, Espert, Lucile, López-Galíndez, Cecilio, Biard-Piechaczyk, Martine, Valenzuela-Fernández, Agustín, and Blanco, Julià

Published
2019
Full Text
View/download PDF

24. Contribution of the HIV-1 Envelope Glycoprotein to AIDS Pathogenesis and Clinical Progression

Author

Valenzuela-Fernández, Agustín, primary, Cabrera-Rodríguez, Romina, additional, Casado, Concha, additional, Pérez-Yanes, Silvia, additional, Pernas, María, additional, García-Luis, Jonay, additional, Marfil, Silvia, additional, Olivares, Isabel, additional, Estévez-Herrera, Judith, additional, Trujillo-González, Rodrigo, additional, Blanco, Julià, additional, and Lopez-Galindez, Cecilio, additional

Published
2022
Full Text
View/download PDF

25. Peripheral and respiratory muscle impairment during murine acute lung injury

Author

Angulo, Martín, primary, Vacca, Agustina, additional, Rodríguez, Romina, additional, Marin, María Noel, additional, Suárez, Ana Laura, additional, Jorge, Gissel, additional, Nosiglia, Oscar, additional, Cambón, Victoria, additional, Ríos, Anaclara, additional, Iglesias, Matías, additional, Seija, Mariana, additional, Escande, Carlos, additional, Hurtado, Javier, additional, and Briva, Arturo, additional

Published
2022
Full Text
View/download PDF

26. Grape-seed proanthocyanidin extract (GSPE) modulates diurnal oscillations of key hepatic metabolic genes and metabolites alleviating hepatic lipid deposition in cafeteria-fed obese rats in a time-of-day-dependent manner

Author

Rodríguez, Romina M, primary, de Assis, Leonardo Vinícius Monteiro, additional, Colom-Pellicer, Marina, additional, Quesada-Vázquez, Sergio, additional, Cruz-Carrión, Álvaro, additional, Escoté, Xavier, additional, Oster, Henrik, additional, Aragonès, Gerard, additional, and Mulero, Miquel, additional

Published
2022
Full Text
View/download PDF

27. Time-of-Day Circadian Modulation of Grape-Seed Procyanidin Extract (GSPE) in Hepatic Mitochondrial Dynamics in Cafeteria-Diet-Induced Obese Rats

Author

Universidad de Sevilla. Departamento de Farmacología, Ministerio de Economía y Competitividad (MINECO). España, Rodríguez, Romina M., Cortés Espinar, Antonio J., Soliz Rueda, Jorge R., Feillet Coudray, Christine, Colom Pellicer, Marina, Aragonès, Gerard, Ávila Román, Francisco Javier, Muguerza, Begoña, Mulero, Miquel, Salvadó, Maria Josepa, Universidad de Sevilla. Departamento de Farmacología, Ministerio de Economía y Competitividad (MINECO). España, Rodríguez, Romina M., Cortés Espinar, Antonio J., Soliz Rueda, Jorge R., Feillet Coudray, Christine, Colom Pellicer, Marina, Aragonès, Gerard, Ávila Román, Francisco Javier, Muguerza, Begoña, Mulero, Miquel, and Salvadó, Maria Josepa

Published
2022

29. Transactive Response DNA-Binding Protein (TARDBP/TDP-43) Regulates Cell Permissivity to HIV-1 Infection by Acting on HDAC6

Author

Cabrera-Rodríguez, Romina, primary, Pérez-Yanes, Silvia, additional, Montelongo, Rafaela, additional, Lorenzo-Salazar, José M., additional, Estévez-Herrera, Judith, additional, García-Luis, Jonay, additional, Íñigo-Campos, Antonio, additional, Rubio-Rodríguez, Luis A., additional, Muñoz-Barrera, Adrián, additional, Trujillo-González, Rodrigo, additional, Dorta-Guerra, Roberto, additional, Casado, Concha, additional, Pernas, María, additional, Blanco, Julià, additional, Flores, Carlos, additional, and Valenzuela-Fernández, Agustín, additional

Published
2022
Full Text
View/download PDF

30. Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption

Author

Colom-Pellicer, Marina, primary, Rodríguez, Romina M., additional, Soliz-Rueda, Jorge R., additional, Assis, Leonardo Vinícius Monteiro de, additional, Navarro-Masip, Èlia, additional, Quesada-Vázquez, Sergio, additional, Escoté, Xavier, additional, Oster, Henrik, additional, Mulero, Miquel, additional, and Aragonès, Gerard, additional

Published
2022
Full Text
View/download PDF

31. Estudio de factores que puedan regular la actividad antiviral de HDAC6, y efecto sobre la capacidad proviral del complejo de envoltura de virus primarios de pacientes VIH+

Author

Cabrera Rodríguez, Romina and Valenzuela Fernández, Agustín

Abstract

Programa de doctorado en Ciencias de la Salud por la Universidad de La Laguna El VIH/SIDA sigue siendo una amenaza global, a pesar de los notables esfuerzos realizados por las comunidades científica y sanitaria para comprender la infección viral, el diseño de nuevos fármacos o la mejora de los existentes, así como del desarrollo de terapias avanzadas y diseño de potenciales vacunas para lograr la cura funcional y la erradicación viral. La identificación y el análisis de individuos VIH-1 positivos que controlan naturalmente la replicación viral, en ausencia de tratamiento antirretroviral, ha brindado pistas sobre los procesos celulares que pueden regular las proteínas y el ARN del virus, y que condicionan los procesos de replicación viral y de progresión clínica de la infección, así como la patología asociada. En la presente tesis doctoral, el principal objetivo de estudio se ha centrado en la proteína de unión al ADN de respuesta transactiva (TAR) 43 (“transactive response DNA-binding protein” (TARDBP o TDP-43)) la cual es reguladora importante del ARNm y, entre otros factores, de la enzima con actividad anti-VIH- 1, histona desacetilasa 6 (HDAC6). La sobreexpresión del constructo funcional parenteral de TDP-43 estabiliza los niveles de ARNm y de proteína de HDAC6, garantizando así sus funciones antivirales en células diana para la infección, afectando a la formación del poro de fusión e inhibiendo la infección por VIH-1, gracias a la actividad desacetiladora de microtúbulos (MT) de la enzima HDAC6, que actúa de forma independiente al tropismo del complejo de envoltura del virus. La regulación de la permisividad celular frente a la infección por VIH-1 por el eje TDP-43/HDAC6, se corrobora por silenciamiento específico del ARNm de TDP- 43, teniendo como consecuencia la disminución en los niveles tanto del ARNm como de la proteína de HDAC6, lo que genera un estatus celular de estabilización de MT que favorece la formación del poro de fusión y la infección del VIH-1, tras el contacto de la Env con el receptor CD4, debido a la reorganización de los MT y su modificación postraduccional por acetilación (por los niveles bajos de HDAC6). Además, y considerando que la Env del VIH-1 es un determinante citopático importante en la infección y replicación viral, y para determinar la funcionalidad viral de Env de virus primarios procedentes de pacientes VIH-1 positivos con fenotipos extremos, se caracterizaron varias Env provenientes de pacientes virémicos no progresores (VNP) o rápidos progresores (RP). Para ello, se realizó un análisis exhaustivo sobre distintos parámetros funcionales de la Env, observándose que los clones de Env, seleccionadas de ambos grupos de pacientes, mostraron capacidades similares de expresión, una afinidad similar por CD4, puesta de manifiesto en ensayos de transmisión de material viral célulacélula y de señalización por CD4 (medidos por acetilación de la subunidad atubulina de los MT), que rigen la capacidad de fusión de membrana (formación del poro de fusión) y de infección, siendo similares en estas Env funcionales. Además, las Env de los dos grupos inducen autofagia tardía por contacto con CD4 en células no infectadas, característica que correlaciona directamente con la actividad fusogénica de las Env. En el caso de los pacientes VNP, no se observa una relación entre la función autofágica tardía letal de las Env virales con la progresión de la enfermedad, si bien los clones de Env de individuos VNP son completamente funcionales y explicaría la viremia en estos pacientes. Todo apunta a que en pacientes VNP el estatus inmunitario aporta cierta estabilidad al fenotipo clínico no progresor. Como prueba de concepto, estas observaciones se confirmaron mediante el estudio de Env virales primarias de individuos infectados por VIH-1 con diferentes fenotipos clínicos, bajo las condiciones experimentales de sobreexpresión de TDP-43. Un aumento en el nivel de expresión de la proteína funcional de TDP-43 redujo fuertemente la actividad de infección de Env de individuos VNP y RP infectados por VIH-1 hasta los niveles de infección detectado para Env provenientes de pacientes controladores de élite, no progresores a largo plazo (LTNP-EC), cuya función viral es deficiente. Por el contrario, niveles bajos de TDP-43 endógeno, inducidos por silenciamiento específico mediante oligonucleótidos interferentes siRNA-TDP-43, favorecen significativamente la actividad de infección de Env primarias de VIH-1 de individuos VNP y RP. Sorprendentemente, el silenciamiento de TDP-43, que reduce los niveles de HDAC6 (su ARNm y proteína), generando un estado celular más permisivo a la infección, permite incluso la infección eficaz celular con pseudovirus portando Env primarias, deficientes en la función viral, de individuos LTNP-EC. Del mismo modo, se estudia cómo TDP-43 ejerce un efecto regulador sobre HDAC6 en células productoras de viriones, al garantizar, mediante la estabilización en los niveles de ARN mensajero (ARNm) y proteína, las funciones autofágicas degradativas de la enzima desacetilasa. Debido a ello, los niveles de proteínas virales Pr55Gag y Vif se ven reducidos, afectando así a la replicación, producción de viriones e infectividad de los mismos. Tras el silenciamiento de TDP-43, se comprueba cómo la actividad autofágica dependiente de HDAC6 se ve reducida, aumentando así la producción viral y la infectividad de los virus generados bajo estas condiciones experimentales, evidenciando la capacidad reguladora de TDP-43 sobre HDAC6 y, consecuentemente, sus actividades antivirales. HIV/AIDS remains a global threat despite the remarkable efforts made by the scientific and health communities to understand this viral infection, to design new drugs or improve existing ones, as well as develop advanced therapies and design vaccines for functional cure, prevention and viral eradication. The identification and analysis of HIV-1 positive individuals who naturally control viral replication in the absence of antiretroviral treatment has provided clues about the cellular processes that might interact with viral proteins and RNA, and define subsequent viral replication and clinical progression. Thus, in this doctoral thesis, the object of study has been focused on the transactive response (TAR) DNA-binding protein (TARDBP or TDP-43), which is an important regulator of mRNA and is known to stabilize the anti-HIV-1 factor, histone deacetylase 6 (HDAC6). The overexpression of the TDP-43 wild type construct stabilizes HDAC6 mRNA and protein levels, thus guaranteeing its antiviral functions in permissive cells for infection, impairing the formation of the fusion pore due to the deacetylating activity in microtubules (MTs) of HDAC6 and independently of the tropism of the viral envelope complex of the virus and, therefore, decreasing the infection ability of the virus. The regulation of cell permissiveness against HIV-1 infection by the TDP-43/HDAC6 axis is corroborated by specific silencing of TDP-43 mRNA, resulting in a decrease in both mRNA and protein levels. of HDAC6, which generates a cellular status of MT stabilization that favors the formation of the fusion pore and the infection of HIV-1, after contact of Env with the CD4 receptor, due to the reorganization of the MTs and their modification post-translational by acetylation (because of low levels of HDAC6). In addition, and considering that the Env of HIV-1 is an important cytopathic determinant in viral infection and replication, and to determine the viral functionality of Env from primary viruses with extreme phenotypes, several Env from viremic non-progressors patients (VNP) or rapid progressors (RP) were characterized. For this, an exhaustive analysis was carried out on different functional parameters of the Env, observing that the Env clones, selected from both groups of patients, showed similar expression capacities, a similar affinity for CD4, revealed in transmission tests of cell-cell viral material and CD4 signaling (measured by acetylation of the a-tubulin subunit of MT), which govern the capacity for membrane fusion (formation of the fusion pore) and infection, being similar in these functional Env . In addition, the Env of the two groups induce late autophagy by contact with CD4 in uninfected cells, a characteristic that directly correlates with the fusogenic activity of the Env. In the case of VNP patients, no relationship is observed between the lethal late autophagic function of viral Env with disease progression, although the Env clones of VNP individuals are fully functional and would explain the viremia in these patients. All these data points to the fact that in VNP patients the immune status provides a certain stability to the non-progressor clinical phenotype. As a proof of concept, these observations were confirmed by studying primary viral Env from HIV-1 infected individuals with different clinical phenotypes, under the experimental conditions of TDP-43 overexpression. An increase in the expression level of wt-TDP-43 strongly reduced Env infection activity from HIV-1 infected VNP and RP individuals to the infection levels detected for Env from elite controllers long-term non-progressors patients (LTNP-EC), whose viral function is impaired. In contrast, low levels of endogenous TDP-43, induced by specific silencing with interfering oligos siRNA-TDP-43, significantly favor the infection activity of primary HIV-1 Env from VNP and RP individuals. Surprisingly, the silencing of TDP-43, which reduces the levels of HDAC6 (its mRNA and protein), generating a cellular state more permissive to infection, even allows efficient cellular infection with pseudoviruses carrying primary Env, deficient in viral function, of LTNP-EC individuals. In the same way, it is also verified how TDP-43 exerts a regulatory effect on HDAC6 in virion-producing cells, by guaranteeing, by stabilizing the levels of mRNA and protein, the autophagic degrading functions of the deacetylating enzyme. Due to this, the levels of viral proteins Pr55Gag and Vif are reduced, thus affecting their replication, virion production and infectivity. After the silencing of TDP-43, it is verified how the autophagic activity dependent on HDAC6 is reduced, thus increasing the viral production and the infectivity of the viruses generated under these experimental conditions, evidencing the regulatory capacity of TDP- 43 on HDAC6 and, consequently, its antiviral activities.

Published
2022

34. The Characteristics of the HIV-1 Env Glycoprotein Are Linked With Viral Pathogenesis

Author

Pérez-Yanes, Silvia, primary, Pernas, María, additional, Marfil, Silvia, additional, Cabrera-Rodríguez, Romina, additional, Ortiz, Raquel, additional, Urrea, Víctor, additional, Rovirosa, Carla, additional, Estévez-Herrera, Judith, additional, Olivares, Isabel, additional, Casado, Concepción, additional, Lopez-Galindez, Cecilio, additional, Blanco, Julià, additional, and Valenzuela-Fernández, Agustín, additional

Published
2022
Full Text
View/download PDF

35. Time-of-Day Circadian Modulation of Grape-Seed Procyanidin Extract (GSPE) in Hepatic Mitochondrial Dynamics in Cafeteria-Diet-Induced Obese Rats

Author

Rodríguez, Romina M., primary, Cortés-Espinar, Antonio J., additional, Soliz-Rueda, Jorge R., additional, Feillet-Coudray, Christine, additional, Casas, François, additional, Colom-Pellicer, Marina, additional, Aragonès, Gerard, additional, Avila-Román, Javier, additional, Muguerza, Begoña, additional, Mulero, Miquel, additional, and Salvadó, Maria Josepa, additional

Published
2022
Full Text
View/download PDF

36. Transactive response DNA-binding Protein (TDP-43) regulates early HIV-1 entry and infection

Author

Cabrera-Rodríguez, Romina, primary, Pérez-Yanes, Silvia, additional, González-Montelongo, Rafaela, additional, Lorenzo-Salazar, José M., additional, Estévez-Herrera, Judith, additional, García-Luis, Jonay, additional, Íñigo-Campos, Antonio, additional, Rubio-Rodríguez, Luis A., additional, Muñoz-Barrera, Adrián, additional, Trujillo-González, Rodrigo, additional, Dorta-Guerra, Roberto, additional, Casado, Concha, additional, Pernas, María, additional, Blanco, Julià, additional, Flores, Carlos, additional, and Valenzuela-Fernández, Agustín, additional

Published
2021
Full Text
View/download PDF

38. The characteristics of the HIV-1 Env glycoprotein contribute to viral pathogenesis

Author

Pérez-Yanes, Silvia, primary, Pernas, Maria, additional, Marfil, Silvia, additional, Cabrera-Rodríguez, Romina, additional, Ortiz, Raquel, additional, Rovirosa, Carla, additional, Estévez-Herrera, Judith, additional, Olivares, Isabel, additional, Casado, Concepción, additional, Lopez-Galindez, Cecilio, additional, Blanco, Julià, additional, and Valenzuela-Fernández, Agustin, additional

Published
2021
Full Text
View/download PDF

39. Zika Virus Pathogenesis: A Battle for Immune Evasion

Author

Estévez-Herrera, Judith, Pérez-Yanes, Silvia, Cabrera-Rodríguez, Romina, Márquez-Arce, Daniel, Trujillo-González, Rodrigo, Machado, José-David, Madrid González, Ricardo, Valenzuela-Fernández, Agustín, Estévez-Herrera, Judith, Pérez-Yanes, Silvia, Cabrera-Rodríguez, Romina, Márquez-Arce, Daniel, Trujillo-González, Rodrigo, Machado, José-David, Madrid González, Ricardo, and Valenzuela-Fernández, Agustín

Abstract

Zika virus (ZIKV) infection and its associated congenital and other neurological disorders, particularly microcephaly and other fetal developmental abnormalities, constitute a World Health Organization (WHO) Zika Virus Research Agenda within the WHO’s R&D Blueprint for Action to Prevent Epidemics, and continue to be a Public Health Emergency of International Concern (PHEIC) today. ZIKV pathogenicity is initiated by viral infection and propagation across multiple placental and fetal tissue barriers, and is critically strengthened by subverting host immunity. ZIKV immune evasion involves viral non-structural proteins, genomic and non-coding RNA and microRNA (miRNA) to modulate interferon (IFN) signaling and production, interfering with intracellular signal pathways and autophagy, and promoting cellular environment changes together with secretion of cellular components to escape innate and adaptive immunity and further infect privileged immune organs/tissues such as the placenta and eyes. This review includes a description of recent advances in the understanding of the mechanisms underlying ZIKV immune modulation and evasion that strongly condition viral pathogenesis, which would certainly contribute to the development of anti-ZIKV strategies, drugs, and vaccines., Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub

Published
2021

40. The Interplay of HIV and Autophagy in Early Infection

Author

Cabrera-Rodríguez, Romina, primary, Pérez-Yanes, Silvia, additional, Estévez-Herrera, Judith, additional, Márquez-Arce, Daniel, additional, Cabrera, Cecilia, additional, Espert, Lucile, additional, Blanco, Julià, additional, and Valenzuela-Fernández, Agustín, additional

Published
2021
Full Text
View/download PDF

41. La frontera como dispositivo de control: Análisis de la construcción material y simbólica de las prácticas transfronterizas en Tarapacá-Chile.

Author

Mendiola Gonzalo, Ignacio, Sociología II, Soziologia II, Ramos Rodríguez, Romina Carolina, Mendiola Gonzalo, Ignacio, Sociología II, Soziologia II, and Ramos Rodríguez, Romina Carolina

Abstract

Embargada por la autora. 415 p., La tesis doctoral que a continuación presentamos, corresponde a un estudio de caso acerca de la conformación territorial de la región de Tarapacá ubicada en el extremo norte de Chile, junto a sus diversas expresiones espaciales y movilidades territoriales. Para indagar en estas expresiones, destacamos los hitos que consideramos más relevantes, particularmente, la influencia de las acciones del Estado nacional chileno en las dinámicas materiales y simbólicas que se desarrollan en este espacio fronterizo.Para ello, hemos prestado especial atención en la percepción de sus habitantes y cruzadores, así como también de las instituciones del Estado que se encuentran apostadas en la frontera. Partimos de la premisa que considera a la frontera como una arquitectura que funciona en clave dispositivo de control al serviciodel poder hegemónico, activándose y desactivándose de acuerdo a la contingencia presentada. Esta investigación pretende -sin intención de ser generativa- conocer las diversas representaciones y producciones espaciales a partir del ejercicio de la vida cotidiana que se (re)produce en este singular territorio.

Published
2020

42. Zika Virus Pathogenesis: A Battle for Immune Evasion

Author

Estévez-Herrera, Judith, primary, Pérez-Yanes, Silvia, additional, Cabrera-Rodríguez, Romina, additional, Márquez-Arce, Daniel, additional, Trujillo-González, Rodrigo, additional, Machado, José-David, additional, Madrid, Ricardo, additional, and Valenzuela-Fernández, Agustín, additional

Published
2021
Full Text
View/download PDF

45. Eficacia de la férula nocturna y el ultrasonido para tratar el síndrome del túnel carpiano. Estudio clínico controlado y aleatorizado

Author

Hernandez, Daniel, primary, Terpolilli, Esteban, additional, Verdecchia, Daniel Héctor, additional, Leiva, Valeria, additional, Ventos, Laura, additional, Rodríguez, Romina, additional, Gamboa, Anabella, additional, Spath, María Belén, additional, Steimberg, Jimena, additional, Sanz, Martín, additional, Williams, Erica, additional, Mohr, Sabrina, additional, Colesnik, Paola, additional, Chen, Tai Lo, additional, Dell' Era, Silvina, additional, Dimaro, Mariana, additional, Díaz, Romina, additional, Baldo, Bruno, additional, and Accoce, Matías, additional

Published
2020
Full Text
View/download PDF

47. Smoke of Capsicum baccatum L. var. baccatum (Solanaceae) repels nymphs of Triatoma infestans (Klug) (Hemiptera: Reduviidae).

Author

Echalar, Jhean-Carla, Cossio-Rodríguez, Romina, Veliz, David, Cardozo-Alarcón, Fabricio, Niemeyer, Hermann M., and Pinto, Carlos F.

Subjects
ASSASSIN bugs, FILTER paper, TRIATOMA, HEMIPTERA, SMOKE, VECTOR control, ANALYTICAL chemistry
Abstract

Copyright of Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas is the property of Universidad de Santiago de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
Full Text
View/download PDF

48. HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

Author

Marrero-Hernández, Sara, Márquez-Arce, Daniel, Cabrera-Rodríguez, Romina, Estévez-Herrera, Judith, Pérez-Yanes, Silvia, Barroso-González, Jonathan, Madrid, Ricardo, Machado, José David, Blanco, Julia, Valenzuela-Fernández, Agustín, Marrero-Hernández, Sara, Márquez-Arce, Daniel, Cabrera-Rodríguez, Romina, Estévez-Herrera, Judith, Pérez-Yanes, Silvia, Barroso-González, Jonathan, Madrid, Ricardo, Machado, José David, Blanco, Julia, and Valenzuela-Fernández, Agustín

Abstract

HIV Nef is a central auxiliary protein in HIV infection and pathogenesis. Our results indicate that HDAC6 promotes the aggresome/autophagic degradation of the viral polyprotein Pr55Gag to inhibit HIV-1 production. Nef counteracts this antiviral activity of HDAC6 by inducing its degradation and subsequently stabilizing Pr55Gag and Vif viral proteins. Nef appears to neutralize HDAC6 by an acidic/endosomal-lysosomal processing and does not need the downregulation function, since data obtained with the non-associated cell-surface Nef-G2A mutant – the cytoplasmic location of HDAC6 – together with studies with chemical inhibitors and other Nef mutants, point to this direction. Hence, the polyproline rich region P72xxP75 (69–77 aa) and the di-Leucin motif in the Nef-ExxxLL160-165 sequence of Nef, appear to be responsible for HDAC6 clearance and, therefore, required for this novel Nef proviral function. Nef and Nef-G2A co-immunoprecipitate with HDAC6, whereas the Nef-PPAA mutant showed a reduced interaction with the anti-HIV-1 enzyme. Thus, the P72xxP75 motif appears to be responsible, directly or indirectly, for the interaction of Nef with HDAC6. Remarkably, by neutralizing HDAC6, Nef assures Pr55Gag location and aggregation at plasma membrane, as observed by TIRFM, promotes viral egress, and enhances the infectivity of viral particles. Consequently, our results suggest that HDAC6 acts as an anti-HIV-1 restriction factor, limiting viral production and infection by targeting Pr55Gag and Vif. This function is counteracted by functional HIV-1 Nef, in order to assure viral production and infection capacities. The interplay between HIV-1 Nef and cellular HDAC6 may determine viral infection and pathogenesis, representing both molecules as key targets to battling HIV., Julià Blanco5,6 and Agustín Valenzuela-Fernández1, Ministerio de Economía y Competitividad (MINECO)/FEDER, Ministerio de Ciencia, Innovación y Universidades (MICINN)/FEDER, Fundación CajaCanarias/FEDER, Red Española de Investigación del SIDA (RES-RETIC)/ISCII/FEDER, Agencia Canaria de Investigación, Innovación y Sociedad de la Información/Fundación CajaCanarias/FEDER, Fundación Canaria Dr. Manuel Morales, Cabildo Tenerife, Fondo de Investigaciones Sanitarias (FIS)/ Instituto de Salud Carlos III (ISCIII), Fundació Institut de Recerca en Ciències de la Salut Germans Trias i Pujol, Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub

Published
2019

49. A Zona de Livre Comércio de Iquique e seu impacto no trabalho informal de mulheres migrantes de fronteira

Author

Icarte Ahumada, Luz, Torres Torres, Natalia, and Ramos Rodríguez, Romina

Subjects
feminização, migraciones, migration, feminization, empleo, migrações, Tarapacá Region, feminización, região de Tarapacá, Free Trade Zone, employement, Zona Franca, emprego, región de Tarapacá
Abstract

Resumen: La Zona Franca de Iquique ha sido un motor sostenido de desarrollo económico en la región de Tarapacá, al norte de Chile. Desde su creación, es un espacio de tránsito de bienes y personas que conecta a Tarapacá con el Centro Oeste Sudamericano. En términos geográficos este espacio resulta ser clave para la circulación debido a su posición fronteriza. Por ello es un atractivo nicho de empleo. ¿Cuáles son las condiciones de empleo que brinda a las mujeres migrantes? A partir de entrevistas realizadas a mujeres migrantes que trabajan en el barrio industrial de la Zona Franca se concluye que la oferta de empleo en este es de tipo precario y ofrece dificultades para realizar trámites administrativos que permitan a las mujeres regularizar su condición migratoria. Abstract: The Free Trade Zone of Iquique has been a sustained engine of economic development in the Tarapacá region, in northern Chile. Since its creation, it has been a transit space for goods and people that connects Tarapacá with the West Central South America. In geographic terms, this space turns out to be key for circulation due to its border position. Therefore, it is an attractive niche for employment. What are the employment conditions that it provides to migrant women? From interviews conducted with migrant women working in the industrial zone of the Free Trade Zone, it is concluded that the job offer in this area is precarious and offers difficulties to perform administrative procedures that allow women to regularize their migratory status. Resumo: A Zona Franca de Iquique tem sido um motor sustentado de desenvolvimento econômico na região de Tarapacá, no norte do Chile. Desde sua criação, é um espaço de trânsito de mercadorias e pessoas que liga Tarapacá ao Centro Oeste Sul-Americano. Em termos geográficos, este espaço acaba por ser fundamental para a circulação devido à sua posição de fronteira. Portanto, é um nicho atraente para o emprego. Quais são as condições de emprego que proporciona às mulheres migrantes? A partir de entrevistas realizadas com mulheres migrantes que trabalham na zona industrial da Zona Franca, conclui-se que a oferta de trabalho nessa área é precária e oferece dificuldades para a realização de procedimentos administrativos que permitam às mulheres regularizar seu status migratório.

Published
2018

50. ENTRE PODER Y RESISTENCIAS: ANÁLISIS DE LAS MOVILIDADES NO TERRITORIALES EN LA ZONA FRONTERIZA DE LA REGIÓN DE TARAPACÁ, CHILE

Author

Ramos Rodríguez, Romina

Subjects
movilidad, border, frontera, Territorio, Territory, región de Tarapacá, mobility, region of Tarapacá
Abstract

Resumen: El monopolio epistemológico del territorio del Estado, en ocasiones, ha sido desarrollado como un constructo indisociable. Sin embargo, aunque el territorio es el objetivo más importante del Estado, creemos que de ninguna manera es la única forma de apropiación espacial. En consecuencia, para lograr la tarea de desmarcar este binomio como producto exclusivo, necesitamos nuevas metáforas y campos de visión que transmitan el alcance completo de una imaginación espacial no territorial. En efecto, desde una perspectiva situada, analizaremos las movilidades de los cruzadores fronterizos de la región de Tarapacá a partir del seguimiento de sus itinerarios de cruce. Con todo, conjeturamos que en el espacio fronterizo tarapaqueño cohabitan expresiones de regulación de movilidad por parte del Estado, y también de prácticas de movilidades temporales por parte de sus habitantes en una relación de permanente disputa. Abstract: The epistemological monopoly of the territory of the State, at times, has been developed as an inseparable construct. However, although the territory is the most important objective of the State, we believe that it is by no means the only form of spatial appropriation. Consequently, to achieve the task of unlocking this binomial as an exclusive product, we need new metaphors and fields of vision that convey the full scope of a non-territorial spatial imagination. In fact, from a situated perspective, we will analyze the mobilities of border crossings in the Tarapacá region based on the monitoring of their crossing itineraries. However, we conjecture that expressions of mobility regulation by the State coexist in the Tarapacá border area, as well as practices of temporary mobility by its inhabitants in a relationship of permanent dispute.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results