Author: "Rodríguez, Eloy" - Searchworks@Jio Institute Digital Library Search Results

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583 results on '"Rodríguez, Eloy"'

1. Age-related hearing loss is not linked to cerebrospinal fluid levels of β-amyloid or p-tau181

Author: Martínez-Dubarbie, Francisco, Lobo, David, Rollán-Martínez-Herrera, María, López-García, Sara, Lage, Carmen, Fernández-Matarrubia, Marta, Pozueta-Cantudo, Ana, García-Martínez, María, Corrales-Pardo, Andrea, Bravo, María, Cobo, Ramón, Cabieces-Juncal, Daniel, López-Hoyos, Marcos, Irure-Ventura, Juan, Sánchez-Juan, Pascual, and Rodríguez-Rodríguez, Eloy
Published: 2024
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2. A transiting, temperate mini-Neptune orbiting the M dwarf TOI-1759 unveiled by TESS

Author: Espinoza, Néstor, Pallé, Enric, Kemmer, Jonas, Luque, Rafael, Caballero, José A., Cifuentes, Carlos, Herrero, Enrique, Béjar, Víctor J. Sánchez, Stock, Stephan, Molaverdikhani, Karan, Morello, Giuseppe, Kossakowski, Diana, Schlecker, Martin, Amado, Pedro J., Bluhm, Paz, Cortés-Contreras, Miriam, Henning, Thomas, Kreidberg, Laura, Kürster, Martin, Lafarga, Marina, Lodieu, Nicolas, Morales, Juan Carlos, Oshagh, Mahmoudreza, Passegger, Vera M., Pavlov, Alexey, Quirrenbach, Andreas, Reffert, Sabine, Reiners, Ansgar, Ribas, Ignasi, Rodríguez, Eloy, López, Cristina Rodríguez, Schweitzer, Andreas, Trifonov, Trifon, Chaturvedi, Priyanka, Dreizler, Stefan, Jeffers, Sandra V., Kaminski, Adrian, López-González, María José, Lillo-Box, Jorge, Montes, David, Nowak, Grzegorz, Pedraz, Santos, Vanaverbeke, Siegfried, Osorio, Maria R. Zapatero, Zechmeister, Mathias, Collins, Karen A., Girardin, Eric, Guerra, Pere, Naves, Ramon, Crossfield, Ian J. M., Matthews, Elisabeth C., Howell, Steve B., Ciardi, David R., Gonzales, Erica, Matson, Rachel A., Beichman, Charles A., Schlieder, Joshua E., Barclay, Thomas, Vezie, Michael, Villaseñor, Jesus Noel, Daylan, Tansu, Mireies, Ismael, Dragomir, Diana, Twicken, Joseph D., Jenkins, Jon, Winn, Joshua N., Latham, David, Ricker, George, and Seager, Sara
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: We report the discovery and characterization of TOI-1759~b, a temperate (400 K) sub-Neptune-sized exoplanet orbiting the M~dwarf TOI-1759 (TIC 408636441). TOI-1759 b was observed by TESS to transit on sectors 16, 17 and 24, with only one transit observed per sector, creating an ambiguity on the orbital period of the planet candidate. Ground-based photometric observations, combined with radial-velocity measurements obtained with the CARMENES spectrograph, confirm an actual period of $18.85019 \pm 0.00014$ d. A joint analysis of all available photometry and radial velocities reveal a radius of $3.17 \pm 0.10\,R_\oplus$ and a mass of $10.8 \pm 1.5\,M_\oplus$. Combining this with the stellar properties derived for TOI-1759 ($R_\star = 0.597 \pm 0.015\,R_\odot$; $M_\star = 0.606 \pm 0.020\,M_\odot$; $T_{\textrm{eff}} = 4065 \pm 51$ K), we compute a transmission spectroscopic metric (TSM) value of over 80 for the planet, making it a good target for transmission spectroscopy studies. TOI-1759 b is among the top five temperate, small exoplanets ($T_\textrm{eq} < 500$ K, $R_p < 4 \,R_\oplus$) with the highest TSM discovered to date. Two additional signals with periods of 80 d and $>$ 200 d seem to be present in our radial velocities. While our data suggest both could arise from stellar activity, the later signal's source and periodicity are hard to pinpoint given the $\sim 200$ d baseline of our radial-velocity campaign with CARMENES. Longer baseline radial-velocity campaigns should be performed in order to unveil the true nature of this long period signal., Comment: 22 pages, 10 figures, 7 tables. AJ in press
Published: 2022
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3. Accuracy of plasma Aβ40, Aβ42, and p-tau181 to detect CSF Alzheimer’s pathological changes in cognitively unimpaired subjects using the Lumipulse automated platform

Author: Martínez-Dubarbie, Francisco, Guerra-Ruiz, Armando, López-García, Sara, Lage, Carmen, Fernández-Matarrubia, Marta, Infante, Jon, Pozueta-Cantudo, Ana, García-Martínez, María, Corrales-Pardo, Andrea, Bravo, María, López-Hoyos, Marcos, Irure-Ventura, Juan, Sánchez-Juan, Pascual, García-Unzueta, María Teresa, and Rodríguez-Rodríguez, Eloy
Published: 2023
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4. Correction to: Age‑related hearing loss is not linked to cerebrospinal fluid levels of β‑amyloid or p‑tau181

Author: Martínez‑Dubarbie, Francisco, Lobo, David, Rollán‑Martínez‑Herrera, María, López‑García, Sara, Lage, Carmen, Fernández‑Matarrubia, Marta, Pozueta‑Cantudo, Ana, García‑Martínez, María, Corrales‑Pardo, Andrea, Bravo, María, Cobo, Ramón, Cabieces-Juncal, Daniel, López‑Hoyos, Marcos, Irure‑Ventura, Juan, Sánchez‑Juan, Pascual, and Rodríguez‑Rodríguez, Eloy
Published: 2024
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5. Monitoring the radio emission of Proxima Centauri

Author: Pérez-Torres, Miguel, Gómez, José Francisco, Ortiz, José Luis, Leto, Paolo, Anglada, Guillem, Gómez, José Luis, Rodríguez, Eloy, Trigilio, Corrado, Amado, Pedro J., Alberdi, Antonio, Anglada-Escudé, Guillem, Osorio, Mayra, Umana, Grazia, Berdiñas, Zaira, López-González, María José, Morales, Nicolás, Rodríguez-López, Cristina, and Chibueze, James
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: We present results from the most comprehensive radio monitoring campaign towards the closest star to our Sun, Proxima Centauri. We report 1.1 to 3.1 GHz observations with the Australian Telescope Compact Array over 18 consecutive days in April 2017. We detect radio emission from Proxima Centauri for most of the observing sessions, which spanned $\sim$1.6 orbital periods of the planet Proxima b. The radio emission is stronger at the low-frequency band, centered around 1.6 GHz, and is consistent with the expected electron-cyclotron frequency for the known star's magnetic field intensity of about 600 Gauss. The 1.6 GHz light curve shows an emission pattern that is consistent with the orbital period of the planet Proxima b around the star Proxima, with its maxima of emission happening near the quadratures. We also observed two short-duration (a few minutes) flares and a long-duration (about three days) burst whose peaks happened close to the quadratures. We find that the frequency, large degree of circular polarization, change of the sign of circular polarization, and intensity of the observed radio emission are all consistent with expectations from electron cyclotron-maser emission arising from sub-Alfv\'enic star-planet interaction. We interpret our radio observations as signatures of interaction between the planet Proxima b and its host star Proxima. We advocate for monitoring other dwarf stars with planets to eventually reveal periodic radio emission due to star-planet interaction, thus opening a new avenue for exoplanet hunting and the study of a new field of exoplanet-star plasma interaction., Comment: 14 pages, 11 figures. Accepted on December 2, 2020 in A&A (main journal), several typos corrected
Published: 2020
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6. Identification and Mitigation of a Vibrational Telescope Systematic with Application to Spitzer

Author: Challener, Ryan C., Harrington, Joseph, Jenkins, James, Kurtovic, Nicolás T., Ramirez, Ricardo, McIntyre, Kathleen J., Himes, Michael D., Rodríguez, Eloy, Anglada-Escudé, Guillem, Dreizler, Stefan, Ofir, Aviv, Rojas, Pablo A. Peña, Ribas, Ignasi, Rojo, Patricio, Kipping, David, Butler, R. Paul, Amado, Pedro J., Rodríguez-López, Cristina, Palle, Enric, and Murgas, Felipe
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: We observed Proxima Centauri with the Spitzer Space Telescope InfraRed Array Camera (IRAC) five times in 2016 and 2017 to search for transits of Proxima Centauri b. Following standard analysis procedures, we found three asymmetric, transit-like events that are now understood to be vibrational systematics. This systematic is correlated with the width of the point-response function (PRF), which we measure with rotated and non-rotated Gaussian fits with respect to the detecor array. We show that the systematic can be removed with a novel application of an adaptive elliptical-aperture photometry technique, and compare the performance of this technique with fixed and variable circular-aperture photometry, using both BiLinearly Interpolated Subpixel Sensitivity (BLISS) maps and non-binned Pixel-Level Decorrelation (PLD). With BLISS maps, elliptical photometry results in a lower standard deviation of normalized residuals, and reduced or similar correlated noise when compared to circular apertures. PLD prefers variable, circular apertures, but generally results in more correlated noise than BLISS. This vibrational effect is likely present in other telescopes and Spitzer observations, where correction could improve results. Our elliptical apertures can be applied to any photometry observations, and may be even more effective when applied to more circular PRFs than Spitzer's., Comment: 18 pages, 12 figures, accepted for publication in PSJ
Published: 2020

7. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Author: Chia, Ruth, Sabir, Marya S, Bandres-Ciga, Sara, Saez-Atienzar, Sara, Reynolds, Regina H, Gustavsson, Emil, Walton, Ronald L, Ahmed, Sarah, Viollet, Coralie, Ding, Jinhui, Makarious, Mary B, Diez-Fairen, Monica, Portley, Makayla K, Shah, Zalak, Abramzon, Yevgeniya, Hernandez, Dena G, Blauwendraat, Cornelis, Stone, David J, Eicher, John, Parkkinen, Laura, Ansorge, Olaf, Clark, Lorraine, Honig, Lawrence S, Marder, Karen, Lemstra, Afina, St George-Hyslop, Peter, Londos, Elisabet, Morgan, Kevin, Lashley, Tammaryn, Warner, Thomas T, Jaunmuktane, Zane, Galasko, Douglas, Santana, Isabel, Tienari, Pentti J, Myllykangas, Liisa, Oinas, Minna, Cairns, Nigel J, Morris, John C, Halliday, Glenda M, Van Deerlin, Vivianna M, Trojanowski, John Q, Grassano, Maurizio, Calvo, Andrea, Mora, Gabriele, Canosa, Antonio, Floris, Gianluca, Bohannan, Ryan C, Brett, Francesca, Gan-Or, Ziv, Geiger, Joshua T, Moore, Anni, May, Patrick, Krüger, Rejko, Goldstein, David S, Lopez, Grisel, Tayebi, Nahid, Sidransky, Ellen, Norcliffe-Kaufmann, Lucy, Palma, Jose-Alberto, Kaufmann, Horacio, Shakkottai, Vikram G, Perkins, Matthew, Newell, Kathy L, Gasser, Thomas, Schulte, Claudia, Landi, Francesco, Salvi, Erika, Cusi, Daniele, Masliah, Eliezer, Kim, Ronald C, Caraway, Chad A, Monuki, Edwin S, Brunetti, Maura, Dawson, Ted M, Rosenthal, Liana S, Albert, Marilyn S, Pletnikova, Olga, Troncoso, Juan C, Flanagan, Margaret E, Mao, Qinwen, Bigio, Eileen H, Rodríguez-Rodríguez, Eloy, Infante, Jon, Lage, Carmen, González-Aramburu, Isabel, Sanchez-Juan, Pascual, Ghetti, Bernardino, Keith, Julia, Black, Sandra E, Masellis, Mario, Rogaeva, Ekaterina, Duyckaerts, Charles, Brice, Alexis, Lesage, Suzanne, Xiromerisiou, Georgia, Barrett, Matthew J, Tilley, Bension S, Gentleman, Steve, Logroscino, Giancarlo, and Serrano, Geidy E
Subjects: Biological Sciences, Genetics, Human Genome, Alzheimer's Disease Related Dementias (ADRD), Prevention, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Aging, Dementia, Brain Disorders, Acquired Cognitive Impairment, Lewy Body Dementia, Biotechnology, Parkinson's Disease, Neurosciences, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adaptor Proteins, Signal Transducing, Alzheimer Disease, Case-Control Studies, Gene Expression Profiling, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Glucosylceramidase, Humans, Lewy Body Disease, Nuclear Proteins, Parkinson Disease, Polymorphism, Single Nucleotide, Tumor Suppressor Proteins, alpha-Synuclein, American Genome Center, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract: The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition.
Published: 2021

8. Proxima Centauri b is not a transiting exoplanet

Author: Jenkins, James S., Harrington, Joseph, Challener, Ryan C., Kurtovic, Nicolás T., Ramirez, Ricardo, Peña, Jose, McIntyre, Kathleen J., Himes, Michael D., Rodríguez, Eloy, Anglada-Escudé, Guillem, Dreizler, Stefan, Ofir, Aviv, Rojas, Pablo A. Peña, Ribas, Ignasi, Rojo, Patricio, Kipping, David, Butler, R. Paul, Amado, Pedro J., Rodríguez-López, Cristina, Kempton, Eliza M. -R., Palle, Enric, and Murgas, Felipe
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract: We report Spitzer Space Telescope observations during predicted transits of the exoplanet Proxima Centauri b. As the nearest terrestrial habitable-zone planet we will ever discover, any potential transit of Proxima b would place strong constraints on its radius, bulk density, and atmosphere. Subsequent transmission spectroscopy and secondary-eclipse measurements could then probe the atmospheric chemistry, physical processes, and orbit, including a search for biosignatures. However, our photometric results rule out planetary transits at the 200~ppm level at 4.5$~{\mu}m$, yielding a 3$\sigma$ upper radius limit of 0.4~$R_\rm{\oplus}$ (Earth radii). Previous claims of possible transits from optical ground- and space-based photometry were likely correlated noise in the data from Proxima Centauri's frequent flaring. Follow-up observations should focus on planetary radio emission, phase curves, and direct imaging. Our study indicates dramatically reduced stellar activity at near-to-mid infrared wavelengths, compared to the optical. Proxima b is an ideal target for space-based infrared telescopes, if their instruments can be configured to handle Proxima's brightness., Comment: 8 pages, 3 figures, 2 tables, accepted for publication in MNRAS
Published: 2019
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9. Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Author: van der Lee, Sven J, Conway, Olivia J, Jansen, Iris, Carrasquillo, Minerva M, Kleineidam, Luca, van den Akker, Erik, Hernández, Isabel, van Eijk, Kristel R, Stringa, Najada, Chen, Jason A, Zettergren, Anna, Andlauer, Till FM, Diez-Fairen, Monica, Simon-Sanchez, Javier, Lleó, Alberto, Zetterberg, Henrik, Nygaard, Marianne, Blauwendraat, Cornelis, Savage, Jeanne E, Mengel-From, Jonas, Moreno-Grau, Sonia, Wagner, Michael, Fortea, Juan, Keogh, Michael J, Blennow, Kaj, Skoog, Ingmar, Friese, Manuel A, Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Tesi, Niccolo, Morris, Christopher M, Indakoetxea, Begoña, Collij, Lyduine E, Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W, van Berckel, Bart NM, Alcolea, Daniel, Wiendl, Heinz, Strickland, Samantha L, Pastor, Pau, Rodríguez Rodríguez, Eloy, DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), Boeve, Bradley F, Petersen, Ronald C, Ferman, Tanis J, van Gerpen, Jay A, Reinders, Marcel JT, Uitti, Ryan J, Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, Boada, Mercè, Zettl, Uwe K, van Schoor, Natasja M, Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K, Ross, Owen A, Dickson, Dennis W, Graff-Radford, Neill R, Knopman, David, Rademakers, Rosa, Lemstra, Afina W, Pijnenburg, Yolande AL, Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F, Hemmer, Bernhard, Huisman, Martijn A, Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A, Sørensen, Thorkild IA, Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, and Clarimón, Jordi
Subjects: DESGESCO, EADB, IFGC, IPDGC, RiMod-FTD, Netherlands Brain Bank, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Acquired Cognitive Impairment, Brain Disorders, Neurodegenerative, Alzheimer's Disease, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Aging, Parkinson's Disease, Genetics, 2.1 Biological and endogenous factors, Neurological, Neurology & Neurosurgery, Clinical Sciences
Abstract: The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.
Published: 2020

10. Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy

Author: Pena-Rodríguez, Eloy, García-Berrocoso, Teresa, Vázquez Fernández, Ezequiel, Otero-Espinar, Francisco J., Abian, Joaquin, and Fernández-Campos, Francisco
Published: 2023
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11. Awareness of Diagnosis in Persons with Early-Stage Alzheimer’s Disease: An Observational Study in Spain

Author: Villarejo-Galende, Alberto, García-Arcelay, Elena, Piñol-Ripoll, Gerard, del Olmo-Rodríguez, Antonio, Viñuela, Félix, Boada, Mercè, Franco-Macías, Emilio, de la Peña, Almudena Ibañez, Riverol, Mario, Puig-Pijoan, Albert, Abizanda-Soler, Pedro, Arroyo, Rafael, Baquero-Toledo, Miquel, Feria-Vilar, Inmaculada, Balasa, Mircea, Berbel, Ángel, Rodríguez-Rodríguez, Eloy, Vieira-Campos, Alba, García-Ribas, Guillermo, Rodrigo-Herrero, Silvia, Lleó, Albert, and Maurino, Jorge
Published: 2022
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12. ALMA Discovery of Dust Belts Around Proxima Centauri

Author: Anglada, Guillem, Amado, Pedro J., Ortiz, Jose L., Gómez, José F., Macías, Enrique, Alberdi, Antxon, Osorio, Mayra, Gómez, José L., de Gregorio-Monsalvo, Itziar, Pérez-Torres, Miguel A., Anglada-Escudé, Guillem, Berdiñas, Zaira M., Jenkins, James S., Jimenez-Serra, Izaskun, Lara, Luisa M., López-González, Maria J., López-Puertas, Manuel, Morales, Nicolas, Ribas, Ignasi, Richards, Anita M. S., Rodríguez-López, Cristina, and Rodriguez, Eloy
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: Proxima Centauri, the star closest to our Sun, is known to host at least one terrestrial planet candidate in a temperate orbit. Here we report the ALMA detection of the star at 1.3 mm wavelength and the discovery of a belt of dust orbiting around it at distances ranging between 1 and 4 au, approximately. Given the low luminosity of the Proxima Centauri star, we estimate a characteristic temperature of about 40 K for this dust, which might constitute the dust component of a small-scale analog to our solar system Kuiper belt. The estimated total mass, including dust and bodies up to 50 km in size, is of the order of 0.01 Earth masses, which is similar to that of the solar Kuiper belt. Our data also show a hint of warmer dust closer to the star. We also find signs of two additional features that might be associated with the Proxima Centauri system, which, however, still require further observations to be confirmed: an outer extremely cold (about 10 K) belt around the star at about 30 au, whose orbital plane is tilted about 45 degrees with respect to the plane of the sky; and additionally, we marginally detect a compact 1.3 mm emission source at a projected distance of about 1.2 arcsec from the star, whose nature is still unknown., Comment: 9 pages, 4 figures, accepted for publication in The Astrophysical Journal Letters
Published: 2017
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13. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Author: van der Lee, Sven J, Conway, Olivia J, Jansen, Iris, Carrasquillo, Minerva M, Kleineidam, Luca, van den Akker, Erik, Hernández, Isabel, van Eijk, Kristel R, Stringa, Najada, Chen, Jason A, Zettergren, Anna, Andlauer, Till FM, Diez-Fairen, Monica, Simon-Sanchez, Javier, Lleó, Alberto, Zetterberg, Henrik, Nygaard, Marianne, Blauwendraat, Cornelis, Savage, Jeanne E, Mengel-From, Jonas, Moreno-Grau, Sonia, Wagner, Michael, Fortea, Juan, Keogh, Michael J, Blennow, Kaj, Skoog, Ingmar, Friese, Manuel A, Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Tesi, Niccolo, Morris, Christopher M, Indakoetxea, Begoña, Collij, Lyduine E, Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W, van Berckel, Bart NM, Alcolea, Daniel, Wiendl, Heinz, Strickland, Samantha L, Pastor, Pau, Rodríguez Rodríguez, Eloy, DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), Boeve, Bradley F, Petersen, Ronald C, Ferman, Tanis J, van Gerpen, Jay A, Reinders, Marcel JT, Uitti, Ryan J, Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, Boada, Mercè, Zettl, Uwe K, van Schoor, Natasja M, Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K, Ross, Owen A, Dickson, Dennis W, Graff-Radford, Neill R, Knopman, David, Rademakers, Rosa, Lemstra, Afina W, Pijnenburg, Yolande AL, Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F, Hemmer, Bernhard, Huisman, Martijn A, Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A, Sørensen, Thorkild IA, Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, and Clarimón, Jordi
Subjects: DESGESCO (Dementia Genetics Spanish Consortium), EADB, EADB, IFGC (International FTD-Genomics Consortium), IPDGC, IPDGC, RiMod-FTD, Netherlands Brain Bank, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Alzheimer’s disease, Amyotrophic lateral sclerosis, Dementia with Lewy bodies, Frontotemporal dementia, Longevity, Multiple sclerosis, Neurodegenerative disease, PLCG2, Parkinson’s disease, Phospholipase C Gamma 2, Progressive supranuclear palsy, Alzheimer's disease, Parkinson's disease, Alzheimer's Disease, frontotemporal dementia, dementia with Lewy-bodies, progressive suprauclear palsy, Parkinson's Disease, amyotrophic lateral sclerosis, multiple sclerosis, neurodegenerative disease, longevity, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract: The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.
Published: 2019

14. Clinical characterisation of patients in the post-acute stage of anti-NMDA receptor encephalitis: a prospective cohort study and comparison with patients with schizophrenia spectrum disorders

Author: Páramo, Dolores, Medrano, Vicente, Casado, Virginia, Guanyabens, Nicolau, Giné-Servén, Eloi, Ángeles del Real, María, Pardo, Javier, Martin-Gil, Leticia, Barrero-Hernández, Francisco Javier, García-Barragán, Nuria, Falip, Mercè, Simó, Marta, Rodríguez, Eloy, Ruiz Ezquerro, Juan José, Bataller, Luis, Safont, Gemma, Vicente-Hervàs, José, Brieva, Luis, Casado, Ignacio, Portilla, Juan Carlos, Escalante, Sònia, Arenillas, Juan Francisco, Erro, Elena, Jericó-Pascual, Ivonne, Fuerte-Hortigón, Alejandro, Morató, Alba, Saiz, Albert, Blanco, Yolanda, Sepúlveda, Maria, Ruiz, Raquel, Naranjo, Laura, Rodés, Maria, Aguilar, Esther, Alba, Mercè, Caballero, Eva, Guasp, Mar, Rosa-Justicia, Mireia, Muñoz-Lopetegi, Amaia, Martínez-Hernández, Eugenia, Armangué, Thais, Sugranyes, Gisela, Stein, Heike, Borràs, Roger, Prades, Laia, Ariño, Helena, Planagumà, Jesús, De-La-Serna, Elena, Escudero, Domingo, Llufriu, Sara, Sánchez-Valle, Raquel, Santamaria, Joan, Compte, Albert, Castro-Fornieles, Josefina, and Dalmau, Josep
Published: 2022
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15. The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals

Author: López-de-Eguileta, Alicia, López-García, Sara, Lage, Carmen, Pozueta, Ana, García-Martínez, María, Kazimierczak, Martha, Bravo, María, Irure, Juan, López-Hoyos, Marcos, Muñoz-Cacho, Pedro, Rodríguez-Perez, Noelia, Tordesillas-Gutiérrez, Diana, Goikoetxea, Alexander, Nebot, Claudia, Rodríguez-Rodríguez, Eloy, Casado, Alfonso, and Sánchez-Juan, Pascual
Published: 2022
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16. A Pulsational Time-evolution Study for the $\delta$ Scuti Star AN Lyncis

Author: Zhou, A. -Y., Hintz, Eric G., Schoonmaker, Jeremy N., Rodríguez, Eloy, Costa, Victor, Lopez-Gonzalez, M. J., Smith, Horace A., Sanders, Nathan, Monninger, Gerold, and Pagel, Lienhard
Subjects: Astrophysics - Solar and Stellar Astrophysics
Abstract: This paper presents a large amount of observations for the $\delta$ Scuti star AN Lyncis carried out in 2001--2012. The extensive observations include two tri-continent campaigns coordinated in 2002 and 2011, respectively, and several single-site contributions throughout the period. The data in total have more than 104100 raw CCD frames and photoelectric records, which consist of 165 nights (about 816 hours) spanning over 3778 days. The final reduced light curves have more than 26500 data points (including those 3462 unpublished BYU data), from which we determined 306 new timings of maximum light. A time-dependent behaviour study based on all available data indicates cyclic amplitude variability as well as period change [for the main periodicity]. Orbital sinusoid fittings to $(O-C)$ residuals and pulsation amplitudes may account for their variations being caused by the light-time effect of AN Lyn in a binary system. The orbital period is about 26--30 years. Current results support the binarity of AN Lyn, first suspected by Zhou (2002). We further show the detailed time evolution structure of the pulsation of AN Lyn as function of both time and period through wavelet analyses., Comment: 23 figures, 5 tables, reduced data, maxima, and raw data available. Submitted initial manuscript, in revision in response to referee's report
Published: 2017

17. LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer's Disease.

Author: García-Martínez, María, Pozueta-Cantudo, Ana, Lage, Carmen, Martínez-Dubarbie, Francisco, López-García, Sara, Fernández-Matarrubia, Marta, Corrales-Pardo, Andrea, Bravo, María, Cavada, Nadia C., Anuarbe, Pedro, Infante, Jon, López-Higuera, José Miguel, Rodríguez-Cobo, Luis, Rodríguez-Rodríguez, Eloy, Butler, Christopher R., and Sánchez-Juan, Pascual
Subjects: ALZHEIMER'S disease, MEMORY testing, VERBAL memory, NEUROPSYCHOLOGICAL tests, COGNITIVE ability, VERBAL learning
Abstract: Background: With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer's disease (AD) pathology in preclinical stages. Objective: To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD. Methods: We studied eighty cognitively healthy volunteers from the Valdecilla cohort. 61% were women and the mean age was 67.34 years (±6.416). All participants underwent a lumbar puncture for determination of CSF biomarkers and an extensive neuropsychological assessment, including performance on learning and associative memory indices of the LAM-test after 30 min and after 1 week, and two classic word lists to assess verbal episodic memory: the Rey Auditory Verbal Learning Test (RAVLT) and the Free and Cued Selective Reminding Test (FCSRT). We analyzed cognitive performance according to amyloid status (A+ versus A–) and to ATN model (A–T–N–; A+T–N–; A+T+N–/A+T+N+). Results: Performance on the LAM-test was significantly correlated with CSF Aβ ratio. A+ participants performed worse on both learning (mean difference = 2.19, p = 0.002) and memory LAM measures than A– (mean difference = 2.19, p = 0.004). A decline in performance was observed along the Alzheimer's continuum, with significant differences between ATN groups. Conclusions: Our findings suggest that LAM test could be a useful tool for the early detection of subjects within the AD continuum, outperforming classical memory tests. [ABSTRACT FROM AUTHOR]
Published: 2024
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18. Where Should I Draw the Line: PET-Driven, Data-Driven, or Manufacturer Cut-Off?

Author: Sánchez-Soblechero, Antonio, primary, López-García, Sara, additional, Lage, Carmen, additional, Fernández-Matarrubia, Marta, additional, Irure, Juan, additional, López-Hoyos, Marcos, additional, Jiménez-Bonilla, Julio, additional, Quirce, Remedios, additional, de Arcocha-Torres, María, additional, Cuenca-Vera, Oriana, additional, Martín-Arroyo, Juan, additional, Martínez-Dubarbie, Francisco, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Infante, Jon, additional, Sánchez-Juan, Pascual, additional, and Rodríguez-Rodríguez, Eloy, additional
Published: 2024
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19. Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired Subjects

Author: Martínez-Dubarbie, Francisco, primary, López-García, Sara, additional, Lage, Carmen, additional, Di Molfetta, Guglielmo, additional, Fernández-Matarrubia, Marta, additional, Pozueta-Cantudo, Ana, additional, García-Martínez, María, additional, Corrales-Pardo, Andrea, additional, Bravo, María, additional, Jiménez-Bonilla, Julio, additional, Quirce, Remedios, additional, Marco de Lucas, Enrique, additional, Drake-Pérez, Marta, additional, Tordesillas, Diana, additional, López-Hoyos, Marcos, additional, Irure-Ventura, Juan, additional, Valeriano-Lorenzo, Elizabeth, additional, Blennow, Kaj, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Rodríguez-Rodríguez, Eloy, additional, and Sánchez-Juan, Pascual, additional
Published: 2024
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20. A terrestrial planet candidate in a temperate orbit around Proxima Centauri

Author: Anglada-Escudé, Guillem, Amado, Pedro J., Barnes, John, Berdiñas, Zaira M., Butler, R. Paul, Coleman, Gavin A. L., de la Cueva, Ignacio, Dreizler, Stefan, Endl, Michael, Giesers, Benjamin, Jeffers, Sandra V., Jenkins, James S., Jones, Hugh R. A., Kiraga, Marcin, Kürster, Martin, López-González, María J., Marvin, Christopher J., Morales, Nicolás, Morin, Julien, Nelson, Richard P., Ortiz, José L., Ofir, Aviv, Paardekooper, Sijme-Jan, Reiners, Ansgar, Rodríguez, Eloy, Rodríguez-López, Cristina, Sarmiento, Luis F., Strachan, John P., Tsapras, Yiannis, Tuomi, Mikko, and Zechmeister, Mathias
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: At a distance of 1.295 parsecs, the red-dwarf Proxima Centauri ($\alpha$ Centauri C, GL 551, HIP 70890, or simply Proxima) is the Sun's closest stellar neighbor and one of the best studied low-mass stars. It has an effective temperature of only $\sim$ 3050 K, a luminosity of $\sim$0.1 per cent solar, a measured radius of 0.14 R$_\odot$ and a mass of about 12 per cent the mass of the Sun. Although Proxima is considered a moderately active star, its rotation period is $\sim$ 83 days, and its quiescent activity levels and X-ray luminosity are comparable to the Sun's. New observations reveal the presence of a small planet orbiting Proxima with a minimum mass of 1.3~Earth masses and an orbital period of $\sim$11.2 days. Its orbital semi-major axis is $\sim0.05$ AU, with an equilibrium temperature in the range where water could be liquid on its surface., Comment: Version accepted for publication by Nature (unedited, July 7th, 2016), figures inserted in text for easier read. Article body : 10 pages, 3 figures, 1 table. Methods section : 23 pages, 9 figures, 1 table. IMPORTANT NOTE : Acknowledgment to IAA/CSIC researchers Javier Pascual Granado and Rafael Garrido added for useful discussions and feedback on the mathematical properties of time-series
Published: 2016
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21. Oculomotor Dysfunction in Idiopathic and LRRK2-Parkinson's Disease and At-Risk Individuals.

Author: Lage, Carmen, Sánchez-Rodríguez, Antonio, Rivera-Sánchez, María, Sierra, María, González-Aramburu, Isabel, Madera, Jorge, Delgado-Alvarado, Manuel, López-García, Sara, Martínez-Dubarbie, Francisco, Fernández-Matarrubia, Marta, Martínez-Amador, Néstor, Martínez-Rodríguez, Isabel, Calvo-Córdoba, Alberto, Rodríguez-Rodríguez, Eloy, García-Cena, Cecilia, Sánchez-Juan, Pascual, and Infante, Jon
Subjects: IDIOPATHIC diseases, PARKINSON'S disease, MOVEMENT disorders, EYE movements, DARDARIN, MEMORY testing
Abstract: Background: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). Objective: To investigate potential oculomotor differences between idiopathic PD (iPD) and PD associated with the G2019S variant of LRRK2 (L2PD), as well as to evaluate oculomotor function in asymptomatic carriers of the G2019S variant of LRRK2. Methods: The study enrolled 129 subjects: 30 PD (16 iPD, 14 L2PD), 23 asymptomatic carriers, 13 non-carrier relatives of L2PD patients, and 63 unrelated HCs. The video-oculographic evaluation included fixation, prosaccade, antisaccade, and memory saccade tests. Results: We did not find significant differences between iPD and L2PD. Compared to controls, PD patients displayed widespread oculomotor deficits including larger microsaccades, hypometric vertical prosaccades, increased latencies in all tests, and lower percentages of successful antisaccades and memory saccades. Non-carrier relatives showed oculomotor changes with parkinsonian features, such as fixation instability and hypometric vertical saccades. Asymptomatic carriers shared multiple similarities with PD, including signs of unstable fixation and hypometric vertical prosaccades; however, they were able to reach percentages of successful antisaccade and memory saccades similar to controls, although at the expense of longer latencies. Classification accuracy of significant oculomotor parameters to differentiate asymptomatic carriers from HCs ranged from 0.68 to 0.74, with BCEA, a marker of global fixation instability, being the parameter with the greatest classification accuracy. Conclusions: iPD and LRRK2-G2019S PD patients do not seem to display a differential oculomotor profile. Several oculomotor changes in asymptomatic carriers of LRRK2 mutations could be considered premotor biomarkers. [ABSTRACT FROM AUTHOR]
Published: 2024
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22. A snake that bites its own tail. Acquisition and loss of concepts in children and semantic dementia patients through the analysis of drawings

Author: Pozueta, Ana, Lage, Carmen, García-Martínez, María, Kazimierczak, Martha, Bravo, María, López-García, Sara, Fernández-Rodríguez, Andrea, Riancho, Javier, González-Suárez, Andrea, Vázquez-Higuera, José Luis, Cano-Abascal, Ángel, Martínez-Dubarbie, Francisco, de Arcocha-Torres, María, Jiménez-Bonilla, Julio, Banzo, Ignacio, Rodríguez-Rodríguez, Eloy, and Sánchez-Juan, Pascual
Published: 2020
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23. Influence of Physiological Variables and Comorbidities on Plasma Aβ40, Aβ42, and p-tau181 Levels in Cognitively Unimpaired Individuals

Author: Martínez-Dubarbie, Francisco, primary, Guerra-Ruiz, Armando, additional, López-García, Sara, additional, Irure-Ventura, Juan, additional, Lage, Carmen, additional, Fernández-Matarrubia, Marta, additional, Pozueta-Cantudo, Ana, additional, García-Martínez, María, additional, Corrales-Pardo, Andrea, additional, Bravo, María, additional, Martín-Arroyo, Juan, additional, Infante, Jon, additional, López-Hoyos, Marcos, additional, García-Unzueta, María Teresa, additional, Sánchez-Juan, Pascual, additional, and Rodríguez-Rodríguez, Eloy, additional
Published: 2024
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24. Medical help-seeking intentions among patients with early Alzheimer’s disease

Author: Villarejo-Galende, Alberto, primary, García-Arcelay, Elena, additional, Piñol-Ripoll, Gerard, additional, del Olmo-Rodríguez, Antonio, additional, Viñuela, Félix, additional, Boada, Mercè, additional, Franco-Macías, Emilio, additional, Ibañez de la Peña, Almudena, additional, Riverol, Mario, additional, Puig-Pijoan, Albert, additional, Abizanda-Soler, Pedro, additional, Arroyo, Rafael, additional, Baquero-Toledo, Miquel, additional, Feria-Vilar, Inmaculada, additional, Balasa, Mircea, additional, Berbel, Ángel, additional, Rodríguez-Rodríguez, Eloy, additional, Vieira-Campos, Alba, additional, Garcia-Ribas, Guillermo, additional, Rodrigo-Herrero, Silvia, additional, Lleó, Alberto, additional, and Maurino, Jorge, additional
Published: 2023
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25. Correction to: Age‑related hearing loss is not linked to cerebrospinal fluid levels of β‑amyloid or p‑tau181

Author: Martínez‑Dubarbie, Francisco, primary, Lobo, David, additional, Rollán‑Martínez‑Herrera, María, additional, López‑García, Sara, additional, Lage, Carmen, additional, Fernández‑Matarrubia, Marta, additional, Pozueta‑Cantudo, Ana, additional, García‑Martínez, María, additional, Corrales‑Pardo, Andrea, additional, Bravo, María, additional, Cobo, Ramón, additional, Cabieces-Juncal, Daniel, additional, López‑Hoyos, Marcos, additional, Irure‑Ventura, Juan, additional, Sánchez‑Juan, Pascual, additional, and Rodríguez‑Rodríguez, Eloy, additional
Published: 2023
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26. Supplementary Material Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy

Author: Pena-Rodríguez, Eloy [0000-0001-8743-7229], García-Berrocoso, Teresa [0000-0001-8072-8533], Abián, Joaquín [0000-0003-2823-5429], Pena-Rodríguez, Eloy, García-Berrocoso, Teresa, Vázquez Fernández, Ezequiel, Otero-Espinar, Francisco J., Abián, Joaquín, Fernández-Campos, Francisco, Pena-Rodríguez, Eloy [0000-0001-8743-7229], García-Berrocoso, Teresa [0000-0001-8072-8533], Abián, Joaquín [0000-0003-2823-5429], Pena-Rodríguez, Eloy, García-Berrocoso, Teresa, Vázquez Fernández, Ezequiel, Otero-Espinar, Francisco J., Abián, Joaquín, and Fernández-Campos, Francisco
Published: 2023

27. Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis

Author: Jansen, Willemijn J, Ossenkoppele, Rik, Knol, Dirk L, Tijms, Betty M, Scheltens, Philip, Verhey, Frans RJ, Visser, Pieter Jelle, Aalten, Pauline, Aarsland, Dag, Alcolea, Daniel, Alexander, Myriam, Almdahl, Ina S, Arnold, Steven E, Baldeiras, Inês, Barthel, Henryk, van Berckel, Bart NM, Bibeau, Kristen, Blennow, Kaj, Brooks, David J, van Buchem, Mark A, Camus, Vincent, Cavedo, Enrica, Chen, Kewei, Chetelat, Gael, Cohen, Ann D, Drzezga, Alexander, Engelborghs, Sebastiaan, Fagan, Anne M, Fladby, Tormod, Fleisher, Adam S, van der Flier, Wiesje M, Ford, Lisa, Förster, Stefan, Fortea, Juan, Foskett, Nadia, Frederiksen, Kristian S, Freund-Levi, Yvonne, Frisoni, Giovanni B, Froelich, Lutz, Gabryelewicz, Tomasz, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Gordon, Mark Forrest, Grimmer, Timo, Hampel, Harald, Hausner, Lucrezia, Hellwig, Sabine, Herukka, Sanna-Kaisa, Hildebrandt, Helmut, Ishihara, Lianna, Ivanoiu, Adrian, Jagust, William J, Johannsen, Peter, Kandimalla, Ramesh, Kapaki, Elisabeth, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E, Köhler, Sebastian, Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G, Van Laere, Koen, Landau, Susan M, Lee, Dong Young, de Leon, Mony, Lisetti, Viviana, Lleó, Alberto, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan, Mattsson, Niklas, de Mendonça, Alexandre, Meulenbroek, Olga, Meyer, Philipp T, Mintun, Mark A, Mok, Vincent, Molinuevo, José Luis, Møllergård, Hanne M, Morris, John C, Mroczko, Barbara, Van der Mussele, Stefan, Na, Duk L, Newberg, Andrew, Nordberg, Agneta, Nordlund, Arto, Novak, Gerald P, Paraskevas, George P, Parnetti, Lucilla, Perera, Gayan, Peters, Oliver, Popp, Julius, Prabhakar, Sudesh, Rabinovici, Gil D, Ramakers, Inez HGB, Rami, Lorena, de Oliveira, Catarina Resende, Rinne, Juha O, Rodrigue, Karen M, and Rodríguez-Rodríguez, Eloy
Subjects: Health Services and Systems, Health Sciences, Clinical Research, Alzheimer's Disease, Vascular Cognitive Impairment/Dementia, Acquired Cognitive Impairment, Neurosciences, Alzheimer's Disease Related Dementias (ADRD), Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Cerebrovascular, Neurodegenerative, Prevention, Dementia, Aging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aetiology, 2.1 Biological and endogenous factors, Neurological, Adult, Age Factors, Aged, Aged, 80 and over, Amyloid beta-Peptides, Apolipoprotein E4, Biomarkers, Brain, Cerebrospinal Fluid, Cognitive Dysfunction, Female, Genotype, Humans, Male, Middle Aged, Positron-Emission Tomography, Prevalence, Risk Factors, Amyloid Biomarker Study Group, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract: ImportanceCerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.ObjectiveTo use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as measured with biomarkers in participants with normal cognition, subjective cognitive impairment (SCI), or mild cognitive impairment (MCI).Data sourcesRelevant biomarker studies identified by searching studies published before April 2015 using the MEDLINE and Web of Science databases and through personal communication with investigators.Study selectionStudies were included if they provided individual participant data for participants without dementia and used an a priori defined cutoff for amyloid positivity.Data extraction and synthesisIndividual records were provided for 2914 participants with normal cognition, 697 with SCI, and 3972 with MCI aged 18 to 100 years from 55 studies.Main outcomes and measuresPrevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations.ResultsThe prevalence of amyloid pathology increased from age 50 to 90 years from 10% (95% CI, 8%-13%) to 44% (95% CI, 37%-51%) among participants with normal cognition; from 12% (95% CI, 8%-18%) to 43% (95% CI, 32%-55%) among patients with SCI; and from 27% (95% CI, 23%-32%) to 71% (95% CI, 66%-76%) among patients with MCI. APOE-ε4 carriers had 2 to 3 times higher prevalence estimates than noncarriers. The age at which 15% of the participants with normal cognition were amyloid positive was approximately 40 years for APOE ε4ε4 carriers, 50 years for ε2ε4 carriers, 55 years for ε3ε4 carriers, 65 years for ε3ε3 carriers, and 95 years for ε2ε3 carriers. Amyloid positivity was more common in highly educated participants but not associated with sex or biomarker modality.Conclusions and relevanceAmong persons without dementia, the prevalence of cerebral amyloid pathology as determined by positron emission tomography or cerebrospinal fluid findings was associated with age, APOE genotype, and presence of cognitive impairment. These findings suggest a 20- to 30-year interval between first development of amyloid positivity and onset of dementia.
Published: 2015

28. Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward more specific detection of prostate cancer

Author: Díaz-Fernández, Ana, Miranda-Castro, Rebeca, de-los-Santos-Álvarez, Noemí, Rodríguez, Eloy Fernández, and Lobo-Castañón, María Jesús
Published: 2019
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29. Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET

Author: López-de-Eguileta, Alicia, Lage, Carmen, López-García, Sara, Pozueta, Ana, García-Martínez, María, Kazimierczak, Martha, Bravo, María, de Arcocha-Torres, María, Banzo, Ignacio, Jimenez-Bonilla, Julio, Cerveró, Andrea, Rodríguez-Rodríguez, Eloy, Sánchez-Juan, Pascual, and Casado, Alfonso
Published: 2019
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30. Precalentamiento quirúrgico, ¿mito o realidad?

Author: Recio Rodríguez, Eloy, primary, Mayoral Díaz, Miguel, additional, and Martí Serrano, Aina, additional
Published: 2023
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31. Depigmenting topical therapy based on a synergistic combination of compounds targeting the key pathways involved in melasma pathophysiology

Author: Martínez‐Gutiérrez Alfredo, Pérez‐Martínez Maribel, Pena‐Rodríguez Eloy, Gómez‐Escalante Susana, Luis G. S. Luis, and González Mari Carmen
Subjects: Dermatology, Molecular Biology, Biochemistry
Published: 2023

32. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis

Author: Aguilera-Albesa, Sergio, Amado-Puentes, Alfonso, Arjona-Padillo, Antonio, Arrabal, Luisa, Arratibel, Izascun, Aznar-Laín, Gemma, Bellas-Lamas, Paula, Bermejo, Teresa, Boyero-Durán, Sabas, Camacho, Ana, Campo, Andrea, Campos, Dulce, Cantarín-Extremera, Verónica, Carnero, Cristóbal, Conejo-Moreno, David, Dapena, Marta, Dacruz-Álvarez, David, Delgadillo-Chilavert, Verónica, Deyà, Angela, Estela-Herrero, Jordi, Felipe, Anna, Fernández-Cooke, Elisa, Fernández-Ramos, Joaquín, Fortuny, Claudia, García-Monco, Juan C, Gili, Teresa, González-Álvarez, Verónica, Guerri, Robert, Guillén, Sara, Hedrera-Fernández, Antonio, López, María, López-Laso, Eduardo, Lorenzo-Ruiz, María, Madruga, Marcos, Málaga-Diéguez, Ignacio, Martí-Carrera, Itxaso, Martínez-Lacasa, Xavier, Martín-Viota, Lucía, Martín Gil, Leticia, Martínez-González, María-Jesús, Moreira, Antia, Miranda-Herrero, María C, Monge, Lorena, Muñoz-Cabello, Beatriz, Navarro-Morón, Juan, Neth, Olaf, Noguera-Julian, Antoni, Nuñez-Enamorado, Noemí, Pomar, Virginia, Portillo-Cuenca, Juan C, Poyato, María, Prieto, Luis, Querol, Luis, Rodríguez-Rodríguez, Eloy, Sarria-Estrada, Silvana, Sierra, Concepción, Soler-Palacín, Pere, Soto-Insuga, Víctor, Toledo-Bravo, Laura, Tomás, Miguel, Torres-Torres, Carmen, Turón, Eulàlia, Zabalza, Ana, Armangue, Thaís, Spatola, Marianna, Vlagea, Alexandru, Mattozzi, Simone, Cárceles-Cordon, Marc, Martinez-Heras, Eloy, Llufriu, Sara, Muchart, Jordi, Erro, María Elena, Abraira, Laura, Moris, German, Monros-Giménez, Luis, Corral-Corral, Íñigo, Montejo, Carmen, Toledo, Manuel, Bataller, Luis, Secondi, Gabriela, Ariño, Helena, Martínez-Hernández, Eugenia, Juan, Manel, Marcos, Maria Angeles, Alsina, Laia, Saiz, Albert, Rosenfeld, Myrna R, Graus, Francesc, and Dalmau, Josep
Published: 2018
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33. Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Author: Mattsson, Niklas, Groot, Colin, Jansen, Willemijn J., Landau, Susan M., Villemagne, Victor L., Engelborghs, Sebastiaan, Mintun, Mark M., Lleo, Alberto, Molinuevo, José Luis, Jagust, William J., Frisoni, Giovanni B., Ivanoiu, Adrian, Chételat, Gaël, Resende de Oliveira, Catarina, Rodrigue, Karen M., Kornhuber, Johannes, Wallin, Anders, Klimkowicz-Mrowiec, Aleksandra, Kandimalla, Ramesh, Popp, Julius, Aalten, Pauline P., Aarsland, Dag, Alcolea, Daniel, Almdahl, Ina S., Baldeiras, Inês, van Buchem, Mark A., Cavedo, Enrica, Chen, Kewei, Cohen, Ann D., Förster, Stefan, Fortea, Juan, Frederiksen, Kristian S., Freund-Levi, Yvonne, Gill, Kiran Dip, Gkatzima, Olymbia, Grimmer, Timo, Hampel, Harald, Herukka, Sanna-Kaisa, Johannsen, Peter, van Laere, Koen, de Leon, Mony J., Maier, Wolfgang, Marcusson, Jan, Meulenbroek, Olga, Møllergård, Hanne M., Morris, John C., Mroczko, Barbara, Nordlund, Arto, Prabhakar, Sudesh, Peters, Oliver, Rami, Lorena, Rodríguez-Rodríguez, Eloy, Roe, Catherine M., Rüther, Eckart, Santana, Isabel, Schröder, Johannes, Seo, Sang W., Soininen, Hilkka, Spiru, Luiza, Stomrud, Erik, Struyfs, Hanne, Teunissen, Charlotte E., Verhey, Frans R.J., Vos, Stephanie J.B., van Waalwijk van Doorn, Linda J.C., Waldemar, Gunhild, Wallin, Åsa K., Wiltfang, Jens, Vandenberghe, Rik, Brooks, David J., Fladby, Tormod, Rowe, Christopher C., Drzezga, Alexander, Verbeek, Marcel M., Sarazin, Marie, Wolk, David A., Fleisher, Adam S., Klunk, William E., Na, Duk L., Sánchez-Juan, Pascual, Lee, Dong Young, Nordberg, Agneta, Tsolaki, Magda, Camus, Vincent, Rinne, Juha O., Fagan, Anne M., Zetterberg, Henrik, Blennow, Kaj, Rabinovici, Gil D., Hansson, Oskar, van Berckel, Bart N.M., van der Flier, Wiesje M., Scheltens, Philip, Visser, Pieter Jelle, and Ossenkoppele, Rik
Published: 2018
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34. Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease

Author: Cantero, Jose L., Atienza, Mercedes, Sanchez-Juan, Pascual, Rodriguez-Rodriguez, Eloy, Vazquez-Higuera, Jose Luis, Pozueta, Ana, Gonzalez-Suarez, Andrea, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Victor, Blesa, Rafael, Alcolea, Daniel, Lleo, Alberto, and Fortea, Juan
Published: 2018
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35. Assessment over-the-head resuscitation method in an inflatable rescue boat sailing at full speed. A non-inferiority pilot study

Author: Barcala-Furelos, Roberto, primary, Carracedo-Rodríguez, Eloy, additional, Lorenzo-Martínez, Miguel, additional, Alonso-Calvete, Alejandra, additional, Otero-Agra, Martín, additional, and Jorge-Soto, Cristina, additional
Published: 2023
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36. A Combination of Compounds With Retinol-boosting Activity as a Skin Aging Treatment.

Author: MARTÍNEZ-GUTIÉRREZ, ALFREDO, PENA-RODRÍGUEZ, ELOY, GÓMEZESCALANTE, SUSANA, CALBET-LLOPART, NEUS, and GONZÁLEZ, MARI CARMEN
Abstract: Retinoids have proven to be effective in skin photoaging treatments. However, undesired side effects limit both their use and dosage in skin care routines. The aim of this research was to test the skin antiaging efficacy of a new combination of compounds including retinol at low doses, bakuchiol, and Lactococcus lysate. Skin aging markers were studied in vitro by qPCR, fibroblast growth stimulation assay, microscopy, and in a full thickness 3D reconstructed skin model by histological analysis. The combination of compounds significantly increased the expression of genes involved in extracellular matrix, growth factors, antioxidant defense, and autophagy, and showed an increased cell proliferation and migration in human dermal fibroblasts. The 3D skin model studies showed an increase in epidermal thickness and the levels of Ki67, procollagen I, COLIV, filaggrin, FGF2, TGFβ1, and cytokeratin 14, which reflects an increase in epidermal regeneration. These results indicate that this combination of compounds is a promising and effective treatment for skin aging and represents a good alternative to the use of high doses of retinoids. [ABSTRACT FROM AUTHOR]
Published: 2024

37. Sistema de monitorización de Temperatura 3MTM Bair HuggerTM

Author: Recio Rodríguez, Eloy, primary
Published: 2023
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38. A Conversation with... Eloy Rodriguez

Author: Rodriguez, Eloy and Campbell, Neil A.
Published: 1996
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39. Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Author: European Research Council, Instituto de Salud Carlos III, Pérez-Tur, Jordi [0000-0002-9111-1712], European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR), Luo, Jiao, Thomassen, Jesper Qvist, Bellenguez, Celine, Grenier-Boley, Benjamin, Rojas, Itziar de, Castillo, Atahualpa, Parveen, Kayenat, Kucukali, Fahri, Nicolas, Aude, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Jurgen, Deckert, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina Porcel, Laura, Duzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Clarimón, Jordi, Moreno, Fermín, Pérez-Tur, Jordi, Bullido, Maria J., Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis Miguel, Piñol-Ripoll, Gerard, García-Alberca, José María, Royo, José Luis, Rodríguez-Rodríguez, Eloy, Soininen, Hilkka, Kuulasmaa, Teemu, Mendonça, Alexandre de, Mehrabian, Shima, Hort, Jakub, Vyhnalek, Martin, van der Lee, Sven, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Bacq-Daian, Delphine, Deleuze, Jean-Francois, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stephanie, Grunblatt, Edna, Popp, Julius, Benussi, Luisa, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Sorbi, Sandro, Caffarra, Paolo, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Masullo, Carlo, Spalletta, Gianfranco, Williams, Julie, Amouyel, Philippe, Jessen, Frank, Kehoe, Patrick, Magda, Tsolaki, Rossi, Giacomina, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Andreassen, Ole A., Hiltunen, Mikko, Van Duijn, Cornelia, Sims, Rebecca, van der Flier, Wiesje, Ruiz, Agustín, Ramírez, Alfredo, Lambert, Jean-Charles, Frikke-Schmidt, Ruth, European Research Council, Instituto de Salud Carlos III, Pérez-Tur, Jordi [0000-0002-9111-1712], European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR), Luo, Jiao, Thomassen, Jesper Qvist, Bellenguez, Celine, Grenier-Boley, Benjamin, Rojas, Itziar de, Castillo, Atahualpa, Parveen, Kayenat, Kucukali, Fahri, Nicolas, Aude, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Jurgen, Deckert, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina Porcel, Laura, Duzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Clarimón, Jordi, Moreno, Fermín, Pérez-Tur, Jordi, Bullido, Maria J., Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis Miguel, Piñol-Ripoll, Gerard, García-Alberca, José María, Royo, José Luis, Rodríguez-Rodríguez, Eloy, Soininen, Hilkka, Kuulasmaa, Teemu, Mendonça, Alexandre de, Mehrabian, Shima, Hort, Jakub, Vyhnalek, Martin, van der Lee, Sven, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Bacq-Daian, Delphine, Deleuze, Jean-Francois, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stephanie, Grunblatt, Edna, Popp, Julius, Benussi, Luisa, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Sorbi, Sandro, Caffarra, Paolo, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Masullo, Carlo, Spalletta, Gianfranco, Williams, Julie, Amouyel, Philippe, Jessen, Frank, Kehoe, Patrick, Magda, Tsolaki, Rossi, Giacomina, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Andreassen, Ole A., Hiltunen, Mikko, Van Duijn, Cornelia, Sims, Rebecca, van der Flier, Wiesje, Ruiz, Agustín, Ramírez, Alfredo, Lambert, Jean-Charles, and Frikke-Schmidt, Ruth
Abstract: Importance: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia. Objective: To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention. Design, setting, and participants: This genetic association study was conducted using 2-sample univariable and multivariable mendelian randomization. Independent genetic variants associated with modifiable risk factors were selected as instrumental variables from genomic consortia. Outcome data for AD were obtained from the European Alzheimer & Dementia Biobank (EADB), generated on August 31, 2021. Main analyses were conducted using the EADB clinically diagnosed end point data. All analyses were performed between April 12 and October 27, 2022. Exposures: Genetically determined modifiable risk factors. Main outcomes and measures: Odds ratios (ORs) and 95% CIs for AD were calculated per 1-unit change of genetically determined risk factors. Results: The EADB-diagnosed cohort included 39 106 participants with clinically diagnosed AD and 401 577 control participants without AD. The mean age ranged from 72 to 83 years for participants with AD and 51 to 80 years for control participants. Among participants with AD, 54% to 75% were female, and among control participants, 48% to 60% were female. Genetically determined high-density lipoprotein (HDL) cholesterol concentrations were associated with increased odds of AD (OR per 1-SD increase, 1.10 [95% CI, 1.05-1.16]). Genetically determined high systolic blood pressure was associated with increased risk of AD after adjusting for diastolic blood pressure (OR per 10-mm Hg increase, 1.22 [95% CI, 1.02-1.46]). In a second analysis to minimize bias due to sample overlap, the entire UK
Published: 2023

40. Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men

Author: Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ace Alzheimer Center Barcelona, Grifols, Fundación la Caixa, European Commission, European Alzheimer's Disease DNA BioBank, García-González, Pablo, Rojas, Itziar de, Moreno-Grau, Sonia, Montrreal, Laura, Puerta, Raquel, Alarcón-Martín, Emilio, Quintela, Inés, Orellana, Adela, Andrade, Victor, Martino-Adami, Pamela V., Heilmann-Heimbach, Stefanie, Gómez-Garre, Pilar, Periñán, María Teresa, Álvarez, Ignacio, Díez-Fairen, Mónica, Nuñez-Llaves, Raul, Olivé-Roig, Claudia, García-Ribas, Guillermo, Menéndez-González, Manuel, Martínez, Carmen, Aguilar Barberá, Miquel, Buongiorno, Maria Teresa, Franco-Macías, Emilio, Sáez, María Eugenia, Cano, Amanda, Bullido, María Jesús, Real, Luis Miguel, Rodríguez-Rodríguez, Eloy, Royo, José Luis, Álvarez, Victoria, Pastor, Pau, Piñol-Ripoll, Gerard, Mir, Pablo, Calero, Miguel, Medina-Padilla, Miguel, Sánchez-Juan, Pascual, Carracedo, Ángel, Valero, Sergi, Hernández, Isabel, Tárraga, Lluís, Ramírez, Alfredo, Boada, Mercè, Ruiz, Agustín, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ace Alzheimer Center Barcelona, Grifols, Fundación la Caixa, European Commission, European Alzheimer's Disease DNA BioBank, García-González, Pablo, Rojas, Itziar de, Moreno-Grau, Sonia, Montrreal, Laura, Puerta, Raquel, Alarcón-Martín, Emilio, Quintela, Inés, Orellana, Adela, Andrade, Victor, Martino-Adami, Pamela V., Heilmann-Heimbach, Stefanie, Gómez-Garre, Pilar, Periñán, María Teresa, Álvarez, Ignacio, Díez-Fairen, Mónica, Nuñez-Llaves, Raul, Olivé-Roig, Claudia, García-Ribas, Guillermo, Menéndez-González, Manuel, Martínez, Carmen, Aguilar Barberá, Miquel, Buongiorno, Maria Teresa, Franco-Macías, Emilio, Sáez, María Eugenia, Cano, Amanda, Bullido, María Jesús, Real, Luis Miguel, Rodríguez-Rodríguez, Eloy, Royo, José Luis, Álvarez, Victoria, Pastor, Pau, Piñol-Ripoll, Gerard, Mir, Pablo, Calero, Miguel, Medina-Padilla, Miguel, Sánchez-Juan, Pascual, Carracedo, Ángel, Valero, Sergi, Hernández, Isabel, Tárraga, Lluís, Ramírez, Alfredo, Boada, Mercè, and Ruiz, Agustín
Abstract: Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the moment of DNA sampling. Therefore, mLOY phenotype associations with AD can be severely age-confounded in the context of genome-wide association studies. Here, we applied Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) using 114 autosomal variants. The mloy-PRS instrument was associated with an 80% increase in mLOY risk per standard deviation unit (p = 4.22 × 10−20) and was orthogonal with age. We found that a higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment (hazard ratio (HR) = 1.23, p = 0.01). Importantly, mloy-PRS had no effect on AD conversion or risk in the female group, suggesting that these associations are caused by the inherent loss of the Y chromosome. Additionally, the blood mLOY phenotype in men was associated with increased cerebrospinal fluid levels of total tau and phosphorylated tau181 in subjects with mild cognitive impairment and dementia. Our results strongly suggest that mLOY is involved in AD pathogenesis.
Published: 2023

41. Planetary companions orbiting the M dwarfs GJ 724 and GJ 3988: A CARMENES and IRD collaboration

Author: Junta de Andalucía, Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), European Commission, Gorrini, Paula, Pozuelos, Francisco J., Caballero, J. A., Amado, Pedro J., Ribas, Ignasi, Cifuentes, C., López González, Maria J., Morales, Juan Carlos, Rodríguez, Eloy, Zapatero Osorio, María Rosa, Zechmeister, Mathias, Junta de Andalucía, Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), European Commission, Gorrini, Paula, Pozuelos, Francisco J., Caballero, J. A., Amado, Pedro J., Ribas, Ignasi, Cifuentes, C., López González, Maria J., Morales, Juan Carlos, Rodríguez, Eloy, Zapatero Osorio, María Rosa, and Zechmeister, Mathias
Abstract: We report the discovery of two exoplanets around the M dwarfs GJ 724 and GJ 3988 using the radial velocity (RV) method. We obtained a total of 153 3.5 m Calar Alto/CARMENES spectra for both targets and measured their RVs and activity indicators. We also added archival ESO/HARPS data for GJ 724 and infrared RV measurements from Subaru/IRD for GJ 3988. We searched for periodic and stable signals to subsequently construct Keplerian models, considering different numbers of planets, and we selected the best models based on their Bayesian evidence. Gaussian process (GP) regression was included in some models to account for activity signals. For both systems, the best model corresponds to one single planet. The minimum masses are 10.75−0.87+0.96 and 3.69−0.41+0.42 Earth-masses for GJ 724 b and GJ 3988 b, respectively. Both planets have short periods (P < 10 d) and, therefore, they orbit their star closely (a < 0.05 au). GJ 724 b has an eccentric orbit (e = 0.577−0.052+0.055), whereas the orbit of GJ 3988 b is circular. The high eccentricity of GJ 724 b makes it the most eccentric single exoplanet (to this date) around an M dwarf. Thus, we suggest a further analysis to understand its configuration in the context of planetary formation and architecture. In contrast, GJ 3988 b is an example of a common type of planet around mid-M dwarfs.
Published: 2023

42. Genetic Associations between Modifiable Risk Factors and Alzheimer Disease

Author: Danish Heart Foundation, Lundbeck Foundation, Luo, Jiao, Thomassen, Jesper Qvist, Bellenguez, Celine, Grenier-Boley, Benjamin, Rojas, Itziar de, Castillo, Atahualpa, Parveen, Kayenat, Kucukali, Fahri, Nicolas, Aude, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Jurgen, Deckert, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina Porcel, Laura, Duzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Clarimón, Jordi, Moreno, Fermín, Pérez-Tur, Jordi, Bullido, Maria J, Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis M, Pinol-Ripoll, Gerard, García-Alberca, José María, Royo, José Luis, Rodríguez-Rodríguez, Eloy, Soininen, Hilkka, Kuulasmaa, Teemu, Mendonça, Alexandre de, Mehrabian, Shima, Hort, Jakub, Vyhnalek, Martin, Van der Lee, Sven, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Bacq-Daian, Delphine, Deleuze, Jean-Francois, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stephanie, Grunblatt, Edna, Popp, Julius, Benussi, Luisa, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Sorbi, Sandro, Caffarra, Paolo, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Masullo, Carlo, Spalletta, Gianfranco, Williams, Julie, Amouyel, Philippe, Jessen, Frank, Kehoe, Patrick, Magda, Tsolaki, Rossi, Giacomina, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Andreassen, Ole A., Hiltunen, Mikko, Van Duijn, Cornelia, Sims, Rebecca, Van der Flier, Wiesje, Ruiz, Agustin, Ramírez, Alfredo, Lambert, Jean-Charles, Frikke-Schmidt, Ruth, Danish Heart Foundation, Lundbeck Foundation, Luo, Jiao, Thomassen, Jesper Qvist, Bellenguez, Celine, Grenier-Boley, Benjamin, Rojas, Itziar de, Castillo, Atahualpa, Parveen, Kayenat, Kucukali, Fahri, Nicolas, Aude, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Jurgen, Deckert, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina Porcel, Laura, Duzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Clarimón, Jordi, Moreno, Fermín, Pérez-Tur, Jordi, Bullido, Maria J, Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis M, Pinol-Ripoll, Gerard, García-Alberca, José María, Royo, José Luis, Rodríguez-Rodríguez, Eloy, Soininen, Hilkka, Kuulasmaa, Teemu, Mendonça, Alexandre de, Mehrabian, Shima, Hort, Jakub, Vyhnalek, Martin, Van der Lee, Sven, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Bacq-Daian, Delphine, Deleuze, Jean-Francois, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stephanie, Grunblatt, Edna, Popp, Julius, Benussi, Luisa, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Sorbi, Sandro, Caffarra, Paolo, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Masullo, Carlo, Spalletta, Gianfranco, Williams, Julie, Amouyel, Philippe, Jessen, Frank, Kehoe, Patrick, Magda, Tsolaki, Rossi, Giacomina, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Andreassen, Ole A., Hiltunen, Mikko, Van Duijn, Cornelia, Sims, Rebecca, Van der Flier, Wiesje, Ruiz, Agustin, Ramírez, Alfredo, Lambert, Jean-Charles, and Frikke-Schmidt, Ruth
Abstract: Importance: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia. Objective: To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention. Design, Setting, and Participants: This genetic association study was conducted using 2-sample univariable and multivariable mendelian randomization. Independent genetic variants associated with modifiable risk factors were selected as instrumental variables from genomic consortia. Outcome data for AD were obtained from the European Alzheimer & Dementia Biobank (EADB), generated on August 31, 2021. Main analyses were conducted using the EADB clinically diagnosed end point data. All analyses were performed between April 12 and October 27, 2022. Exposures: Genetically determined modifiable risk factors. Main Outcomes and Measures: Odds ratios (ORs) and 95% CIs for AD were calculated per 1-unit change of genetically determined risk factors. Results: The EADB-diagnosed cohort included 39106 participants with clinically diagnosed AD and 401577 control participants without AD. The mean age ranged from 72 to 83 years for participants with AD and 51 to 80 years for control participants. Among participants with AD, 54% to 75% were female, and among control participants, 48% to 60% were female. Genetically determined high-density lipoprotein (HDL) cholesterol concentrations were associated with increased odds of AD (OR per 1-SD increase, 1.10 [95% CI, 1.05-1.16]). Genetically determined high systolic blood pressure was associated with increased risk of AD after adjusting for diastolic blood pressure (OR per 10-mm Hg increase, 1.22 [95% CI, 1.02-1.46]). In a second analysis to minimize bias due to sample overlap, the entire UK B
Published: 2023

43. Two sub-Neptunes around the M dwarf TOI-1470

Author: Ministerio de Ciencia e Innovación (España), European Commission, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Japan Society for the Promotion of Science, Generalitat de Catalunya, Junta de Andalucía, González-Álvarez, E., Zapatero Osorio, María Rosa, Caballero, J. A., Cifuentes, C., Herrero Casas, Enrique, López González, Maria J., Rodríguez, Eloy, Rodríguez-López, Cristina, Sanz-Forcada, J., Tabernero, H. M., Amado, Pedro J., Ribas, Ignasi, Ministerio de Ciencia e Innovación (España), European Commission, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Japan Society for the Promotion of Science, Generalitat de Catalunya, Junta de Andalucía, González-Álvarez, E., Zapatero Osorio, María Rosa, Caballero, J. A., Cifuentes, C., Herrero Casas, Enrique, López González, Maria J., Rodríguez, Eloy, Rodríguez-López, Cristina, Sanz-Forcada, J., Tabernero, H. M., Amado, Pedro J., and Ribas, Ignasi
Abstract: [Aims] A transiting planet candidate with a sub-Neptune radius orbiting the nearby (d = 51.9 ± 0.07 pc) M1.5 V star TOI-1470 with a period of ~2.5 d was announced by the NASA Transiting Exoplanet Survey Satellite (TESS), which observed the field of TOI-1470 in four different sectors. We aim to validate its planetary nature using precise radial velocities (RVs) taken with the CARMENES spectrograph., [Methods] We obtained 44 RV measurements with CARMENES spanning eight months between 3 June 2020 and 17 January 2021. For a better characterization of the parent star activity, we also collected contemporaneous optical photometric observations at the Joan Oró and Sierra Nevada Observatories, and we retrieved archival photometry from the literature. We used ground-based photometric observations from MuSCAT and also from MuSCAT2 and MuSCAT3 to confirm the planetary transit signals. We performed a combined photometric and spectroscopic analysis by including Gaussian processes and Keplerian orbits to simultaneously account for the stellar activity and planetary signals., [Results] We estimate that TOI-1470 has a rotation period of 29 ± 3d based on photometric and spectroscopic data. The combined analysis confirms the discovery of the announced transiting planet, TOI-1470 b, with an orbital period of 2.527093 ± 0.000003 d, a mass of 7.32-1.24+1.21M⊕, and a radius of 2.18-0.04+0.04R⊕. We also discover a second transiting planet that was not announced previously by TESS, TOI-1470 c, with an orbital period of 18.08816 ± 0.00006 d, a mass of 7.24-2.77+2.87M⊕, and a radius of 2.47-0.02+0.02R⊕ . The two planets are placed on the same side of the radius valley of M dwarfs and lie between TOI-1470 and the inner border of its habitable zone.
Published: 2023

44. Assessment of over-the-head resuscitation method in an inflatable rescue boat sailing at full speed. A non-inferiority pilot study

Author: Barcala-Furelos, Roberto, Carracedo-Rodríguez, Eloy, Lorenzo-Martínez, Miguel, Alonso-Calvete, Alejandra, Otero-Agra, Martín, and Jorge-Soto, Cristina
Published: 2023
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45. Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Author: Rojas, Itziar de, Hernández, Isabel, Montrreal, Laura, Quintela, Inés, Calero, Miguel, Royo, José Luis, Huerto Vilas, Raquel, González-Pérez, Antonio, Franco-Macías, Emilio, Macias, Juan, Menéndez-González, Manuel, Frank-García, Ana, Díez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, Aguilera, Nuria, Garcia-González, Pablo, Puerta, Raquel, Sotolongo-Grau, Oscar, Alonso-Lana, Silvia, Rábano, Alberto, Arias Pastor, Alfonso, Pastor, Ana Belén, Corma-Gómez, Anaïs, Martin Montes, Ángel, Martínez Rodríguez, Carmen, Buiza-Rueda, Dolores, Periñán, María Teresa, Rodríguez-Rodríguez, Eloy, Álvarez, Ignacio, Rosas Allende, Irene, Pineda, Juan A., Bernal Sánchez-Arjona, María, Fernández-Fuertes, Marta, Mendoza, Silvia, Ser, Teodoro del, GR@ACE, DEGESCO Consortium, García-Ribas, Guillermo, Sanchez-Juan, Pascual, Pastor, Pau, Bullido, María Jesús, Álvarez, Victoria, Real, Luis M., Mir, Pablo, Piñol-Ripoll, Gerard, García-Alberca, José María, Medina, Miguel, Orellana, Adelina, Butler, Christopher R., Marquie, Marta, Sáez, María Eugenia, Carracedo, Ángel, Tárraga, Lluís, Boada, Mercè, Ruiz, Agustín, Instituto de Salud Carlos III, Unión Europea, Grifols (Spain), Fundación La Caixa, Fundació ACE, Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas), Fundación Reina Sofía, Grifols, La Caixa, Ace Alzheimer Center Barcelona, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), European Commission, Rojas, Itziar de [0000-0002-2148-381X], Calero, Miguel [0000-0001-5366-3324], Menéndez-González, Manuel [0000-0002-5218-0774], Díez-Fairen, Mónica [0000-0003-1882-0309], Rábano, Alberto [0000-0001-9320-6566], Rodríguez-Rodríguez, Eloy [0000-0001-7742-677X], Álvarez, Ignacio [0000-0002-8537-3935], Bullido, María Jesús [0000-0002-6477-1117], Álvarez, Victoria [0000-0002-1916-2523], Real, Luis M. [0000-0003-4932-7429], Medina, Miguel [0000-0002-7016-5340], Butler, Christopher R. [0000-0002-7502-9284], Sáez, María Eugenia [0000-0001-9299-2534], Carracedo, Ángel [0000-0003-1085-8986], Ruiz, Agustín [0000-0003-2633-2495], Universidad de Cantabria, Rojas, Itziar de, Calero, Miguel, Menéndez-González, Manuel, Díez-Fairen, Mónica, Rábano, Alberto, Rodríguez-Rodríguez, Eloy, Álvarez, Ignacio, Bullido, María Jesús, Álvarez, Victoria, Real, Luis M., Medina, Miguel, Butler, Christopher R., Sáez, María Eugenia, Carracedo, Ángel, Ruiz, Agustín, and UAM. Departamento de Biología Molecular
Subjects: SARS-CoV-2, COVID-19, GWAS, GR@ACE/DEGESCO, dementia, APOE, Medicine (miscellaneous), Biología y Biomedicina / Biología, Article, Medicine
Abstract: Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis., We would like to thank patients and controls who participated in this project. The present work has been performed as part of the doctoral program of I. de Rojas at the Universitat de Barcelona (Barcelona, Spain) supported by national grant from the Instituto de Salud Carlos III FI20/00215. The Genome Research @ Fundació ACE project (GR@ACE) is supported by Grifols SA, Fundación bancaria ‘La Caixa’, Fundació ACE, and CIBERNED. The Vallecas Project is supported by Queen Sofia Foundation and the Instituto de Salud Carlos III. The position held by SA-L is funded by Instituto de Salud Carlos III (Co-funded by European Social Fund “Investing in your future”) Sara Borrell Contract (CD19/00232). A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240 and PI19/01301. Acción Estratégica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)–Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER–‘Una manera de hacer Europa’). Some control samples and data from patients included in this study were provided in part by the National DNA Bank Carlos III (www.bancoadn.org, accessed date: 1 October 2021, University of Salamanca, Spain) and Hospital Universitario Virgen de Valme (Sevilla, Spain); they were processed following standard operating procedures with the appropriate approval of the Ethical and Scientific Committee. This research has been conducted using the COVID-19 Host Genetic Initiative public resource obtained through the web site (https://www.covid19hg.org/results/, accessed date: 1 October 2021).
Published: 2021

46. A 5-year longitudinal evaluation in patients with mild cognitive impairment by 11C-PIB PET/CT: a visual analysis

Author: Jiménez-Bonilla, Julio F., Quirce, Remedios, De Arcocha-Torres, María, Martínez-Rodríguez, Isabel, Martínez-Amador, Néstor, Sánchez-Salmón, Aida, De la Fuente-Gómez, Francisco, Rodríguez, Eloy, Sánchez-Juan, Pascual, and Banzo, Ignacio
Published: 2019
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47. Voices in Molecular Pharmaceutics: Meet Dr. Eloy Pena-Rodríguez, Nanoparticle Engineer for Transdermal Delivery

Author: Pena-Rodríguez, Eloy, primary
Published: 2023
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48. Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men

Author: García-González, Pablo, primary, de Rojas, Itziar, additional, Moreno-Grau, Sonia, additional, Montrreal, Laura, additional, Puerta, Raquel, additional, Alarcón-Martín, Emilio, additional, Quintela, Inés, additional, Orellana, Adela, additional, Andrade, Victor, additional, Adami, Pamela V. Martino, additional, Heilmann-Heimbach, Stefanie, additional, Gomez-Garre, Pilar, additional, Periñán, María Teresa, additional, Alvarez, Ignacio, additional, Diez-Fairen, Monica, additional, Nuñez Llaves, Raul, additional, Olivé Roig, Claudia, additional, Garcia-Ribas, Guillermo, additional, Menéndez-González, Manuel, additional, Martínez, Carmen, additional, Aguilar, Miquel, additional, Buongiorno, Mariateresa, additional, Franco-Macías, Emilio, additional, Saez, Maria Eugenia, additional, Cano, Amanda, additional, Bullido, Maria J., additional, Real, Luis Miguel, additional, Rodríguez-Rodríguez, Eloy, additional, Royo, Jose Luís, additional, Álvarez, Victoria, additional, Pastor, Pau, additional, Piñol-Ripoll, Gerard, additional, Mir, Pablo, additional, Lara, Miguel Calero, additional, Padilla, Miguel Medina, additional, Sánchez-Juan, Pascual, additional, Carracedo, Angel, additional, Valero, Sergi, additional, Hernandez, Isabel, additional, Tàrraga, Lluis, additional, Ramirez, Alfredo, additional, Boada, Mercé, additional, and Ruiz, Agustín, additional
Published: 2023
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49. Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

Author: Alcolea, Daniel, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Victor, Sánchez-Juan, Pascual, González-Suárez, Andrea, Pozueta, Ana, Rodríguez-Rodríguez, Eloy, Bartrés-Faz, David, Vidal-Piñeiro, Dídac, González-Ortiz, Sofía, Medrano, Santiago, Carmona-Iragui, María, Sánchez-Saudinós, M<ce:sup loc='post">a</ce:sup>Belén, Sala, Isabel, Anton-Aguirre, Sofía, Sampedro, Frederic, Morenas-Rodríguez, Estrella, Clarimón, Jordi, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan
Published: 2015
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50. Latanoprost-Loaded Nanotransfersomes Designed for Scalp Administration Enhance Keratinocytes Proliferation

Author: Pena-Rodríguez, Eloy, primary, García-Vega, Laura, additional, Lajarin Reinares, Maria, additional, Pastor-Anglada, Marçal, additional, Pérez-Torras, Sandra, additional, and Fernandez-Campos, Francisco, additional
Published: 2022
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