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1. Epidemiology of perioperative anaphylaxis in France in 2017–2018: the 11th GERAP survey

Author

Martine, Morisset, Solène, Husser, Vinh An, Huyn, Mélanie, Perquin, Florence, Lakkis-Castelain, Christine, Feesenmeyer, Christelle, Pellerin, Marilyne, Bordes-Demolis, Antoine, Giraudon, Elleni, Vaia, Delphine, Mariotte, Yann, Ollivier, Julien, Serrier, Georgia, Dalampira, Daniela, Muti, Charlotte, Baud, Ferrand, Clermont, Rosita, Capo-Chichi, Sandrine, Seltzer, Sophie, Vandenbergue-Durr, Valentina, Zambelli, Eloïse, Pottier, Amélie, Mear, Guillaume, Pouessel, Alain, Facon, De Chambure Diane, Pelletier, Christine, Delebarre-Sauvage, Juliette, Caron, Elisabeth, Bellet, Isabelle, Orsel, Le Quang, Diane, Christelle, Mullet, Nathalie, Diot-Junique, Rolande, Ferrenq-Dubost, Carine, Billard, Sébastien, Lefervre, Anca, Chiriac, Pascal, Demoly, Marion, Gouitaa, Eva, Serrano, Marie, Tezier, El Hanache, Hassan, Luc, Colas, Emmanuelle, Aguinet, Isabelle, Petit, Gilles, Rezzadori, Minaxi, Patel, Sophie, Miran, Aïcha, Merzouk, Magdalena, Smilov, Aurélie, Gouel-Cheron, Catherine, Neukirch, Chantal, Karila-Beaulier, David, Lepage, Alice, Seringulian, Marion, Verdaguer, Valérie, Renauld, Jean-Marc, Malinovsky, Cécile, Rochefort-Morel, Sabrina, Dessard, Le Guillou, Lisa, Sébastien, Franchina, Yannick, Meunier, Emmanuel, Girard, Samer, Nafeh, Cédric, Delzanno, Charles, Dzviga, Rodolphe, Stenger, Charles, Tacquard, Paul-Michel, Mertes, Le Guen, Morgan, Céline, Gil, Claire, Mailhol, Isabelle, Migueres, Cyrille, Hoarau, Tacquard, Charles, Serrier, Julien, Viville, Simon, Chiriac, Anca-Mirela, Franchina, Sébastien, Gouel-Cheron, Aurélie, Giraudon, Antoine, Malinovsky, Jean-Marc, Petitpain, Nadine, Demoly, Pascal, and Mertes, Paul M.

Published
2024
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2. Epidemiology of perioperative anaphylaxis in France in 2017–2018: the 11th GERAP survey

Author

Tacquard, Charles, primary, Serrier, Julien, additional, Viville, Simon, additional, Chiriac, Anca-Mirela, additional, Franchina, Sébastien, additional, Gouel-Cheron, Aurélie, additional, Giraudon, Antoine, additional, Le Guen, Morgan, additional, Le Quang, Diane, additional, Malinovsky, Jean-Marc, additional, Petitpain, Nadine, additional, Demoly, Pascal, additional, Mertes, Paul M., additional, Martine, Morisset, additional, Solène, Husser, additional, Vinh An, Huyn, additional, Mélanie, Perquin, additional, Florence, Lakkis-Castelain, additional, Christine, Feesenmeyer, additional, Christelle, Pellerin, additional, Marilyne, Bordes-Demolis, additional, Antoine, Giraudon, additional, Elleni, Vaia, additional, Delphine, Mariotte, additional, Yann, Ollivier, additional, Julien, Serrier, additional, Georgia, Dalampira, additional, Daniela, Muti, additional, Charlotte, Baud, additional, Ferrand, Clermont, additional, Rosita, Capo-Chichi, additional, Sandrine, Seltzer, additional, Sophie, Vandenbergue-Durr, additional, Valentina, Zambelli, additional, Eloïse, Pottier, additional, Amélie, Mear, additional, Guillaume, Pouessel, additional, Alain, Facon, additional, De Chambure Diane, Pelletier, additional, Christine, Delebarre-Sauvage, additional, Juliette, Caron, additional, Elisabeth, Bellet, additional, Isabelle, Orsel, additional, Christelle, Mullet, additional, Nathalie, Diot-Junique, additional, Rolande, Ferrenq-Dubost, additional, Carine, Billard, additional, Sébastien, Lefervre, additional, Anca, Chiriac, additional, Pascal, Demoly, additional, Marion, Gouitaa, additional, Eva, Serrano, additional, Marie, Tezier, additional, El Hanache, Hassan, additional, Luc, Colas, additional, Emmanuelle, Aguinet, additional, Isabelle, Petit, additional, Gilles, Rezzadori, additional, Minaxi, Patel, additional, Sophie, Miran, additional, Aïcha, Merzouk, additional, Magdalena, Smilov, additional, Aurélie, Gouel-Cheron, additional, Catherine, Neukirch, additional, Chantal, Karila-Beaulier, additional, David, Lepage, additional, Alice, Seringulian, additional, Marion, Verdaguer, additional, Valérie, Renauld, additional, Jean-Marc, Malinovsky, additional, Cécile, Rochefort-Morel, additional, Sabrina, Dessard, additional, Le Guillou, Lisa, additional, Sébastien, Franchina, additional, Yannick, Meunier, additional, Emmanuel, Girard, additional, Samer, Nafeh, additional, Cédric, Delzanno, additional, Charles, Dzviga, additional, Rodolphe, Stenger, additional, Charles, Tacquard, additional, Paul-Michel, Mertes, additional, Céline, Gil, additional, Claire, Mailhol, additional, Isabelle, Migueres, additional, and Cyrille, Hoarau, additional

Published
2024
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3. Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study

Author

Paul Michel Mertes, Nadine Petitpain, Charles Tacquard, Marion Delpuech, Cédric Baumann, Jean Marc Malinovsky, Dan Longrois, Aurélie Gouel-Cheron, Diane Le Quang, Pascal Demoly, Jean Louis Guéant, Pierre Gillet, Emmanuelle Aguinet, Pol André Apoil, Jean Eric Autegarden, Faiza Bettayeb, Céline Biermann, Maryline Bordes-demolis, Anca Chiriac, Pierre Antoine Darene, Frédéric Deblay, Sabrina Dessard, Charles Dzviga, Hassan El Hanache, Alain Facon, Yannick Fuhrer, Noémie Gest, Marion Gouitaa, Adela Harpan, Cyrille Hoarau, Lisa Le Guillou, Laurence Lepeltier, Claire Mailhol, Delphine Mariotte, Yannick Meunier, Isabelle Migueres, Martine Morisset, Catherine Neukirch, Dalila Nouar, Yann Ollivier, Isabelle Orsel, Omar Outtas, Minaxi Patel, Christelle Pellerin, Isabelle Petit, Anaïs Pipet, Cécile Rochefort-Morel, Claire Schwartz, Sandrine Seltzer, Alice Seringulian, Angèle Soria, Lilia Soufir, Rodolphe Stenger, Céline Tummino, Marion Verdaguer, Les Hôpitaux Universitaires de Strasbourg (HUS), Biologie et Pharmacologie des Plaquettes sanguines : hémostase, thrombose, transfusion (BPP), Université de Strasbourg (UNISTRA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Nouvel Hôpital Civil de Strasbourg, Centre Régional de PharmacoVigilance de Lorraine (CRPV Lorraine), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Département Méthodologie Promotion Investigation [CHRU Nancy] (MPI), Centre Hospitalier Universitaire de Reims (CHU Reims), Hémostase et Remodelage Vasculaire Post-Ischémie (HERVI - EA 3801), Université de Reims Champagne-Ardenne (URCA), Service d'anesthésie - réanimation chirurgicale [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre de référence des maladies héréditaires du métabolisme (MaMEA Nancy-Brabois), Service d'Hépato-gastro-entérologie [CHRU Nancy], Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Service de Pharmacologie Clinique et Toxicologie [CHRU Nancy], The ALPHO study NCT02250729 was requested and supported by the European Medicines Agency (EMA). It was funded by a consortium of pharmaceutical companies marketing pholcodine (Zambon, Urgo, Les Laboratoires Pierre Fabre, Boots, Hepatoum, Biocodex, Sanofi, Laboratoires Bouchara Recordati, GlaxoSmithKline, Alliance Pharmaceuticals Ltd, Bells Healthcare, Pinewood, T & R, Ernest Jackson, Vemedia)., and ALPHO Study Group: Emmanuelle Aguinet, Pol André Apoil, Jean Eric Autegarden, Faiza Bettayeb, Céline Biermann, Maryline Bordes-Demolis, Anca Chiriac, Pierre Antoine Darene, Frédéric Deblay, Sabrina Dessard, Charles Dzviga, Hassan El Hanache, Alain Facon, Yannick Fuhrer, Noémie Gest, Marion Gouitaa, Adela Harpan, Cyrille Hoarau, Lisa Le Guillou, Laurence Lepeltier, Claire Mailhol, Delphine Mariotte, Yannick Meunier, Isabelle Migueres, Martine Morisset, Catherine Neukirch, Dalila Nouar, Yann Ollivier, Isabelle Orsel, Omar Outtas, Minaxi Patel, Christelle Pellerin, Isabelle Petit, Anaïs Pipet, Cécile Rochefort-Morel, Claire Schwartz, Sandrine Seltzer, Alice Seringulian, Angèle Soria, Lilia Soufir, Rodolphe Stenger, Céline Tummino, Marion Verdaguer

Subjects
Anesthesiology and Pain Medicine, [SDV]Life Sciences [q-bio], anaphylaxis, anaesthesia, quaternary ammonium compounds, neuromuscular blocking agents, pholcodine
Abstract

International audience; BackgroundNeuromuscular blocking agents (NMBAs) are among the leading cause of perioperative anaphylaxis, and most of these reactions are IgE mediated. Allergic sensitisation induced by environmental exposure to other quaternary ammonium-containing compounds, such as pholcodine, has been suggested. The aim of this study was to assess the relationship between pholcodine exposure and NMBA-related anaphylaxis.MethodsALPHO was a multicentre case-control study, comparing pholcodine exposure within a year before anaesthesia between patients with NMBA-related perioperative anaphylaxis (cases) and control patients with uneventful anaesthesia in France. Each case was matched to two controls by age, sex, type of NMBA, geographic area, and season. Pholcodine exposure was assessed by a self-administered questionnaire and pharmaceutical history retrieved from pharmacy records. The diagnostic values of anti-pholcodine and anti-quaternary ammonium specific IgE (sIgE) were also evaluated.ResultsOverall, 167 cases were matched with 334 controls. NMBA-related anaphylaxis was significantly associated with pholcodine consumption (odds ratio 4.2; 95% confidence interval 2.3–7.0) and occupational exposure to quaternary ammonium compounds (odds ratio 6.1; 95% confidence interval 2.7–13.6), suggesting that apart from pholcodine, other environmental factors can also lead to sensitisation to NMBAs. Pholcodine and quaternary ammonium sIgEs had a high negative predictive value (99.9%) but a very low positive predictive value (

Published
2023
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4. Cyfra 21-1 as a Biologic Marker of Non-small Cell Lung Cancer

Author

Bram Wieskopf, Elisabeth Quoix, Ashok Purohit, Christine Demangeat, Rodolphe Stenger, Harvey Kreisman, and Pascal Gries

Subjects
Pulmonary and Respiratory Medicine, Biologic marker, Oncology, Pathology, medicine.medical_specialty, Performance status, biology, business.industry, Critical Care and Intensive Care Medicine, medicine.disease, respiratory tract diseases, Carcinoembryonic antigen, Internal medicine, Carcinoma, biology.protein, Medicine, Stage (cooking), Cardiology and Cardiovascular Medicine, business, CYFRA 21-1, Lung cancer, Tumor marker
Abstract

Background: Cytokeratins are epithelial markers whose expression is not lost during malignant transformation. Cyfra 21-1 is a cytokeratin-19 fragment that is soluble in serum and may be a useful circulating tumor marker. Study objective: The aims of this study were (1) to confirm sensitivity and specificity of Cyfra 21-1 in detecting non-small cell lung cancer (NSCLC) and especially the squamous cell subtype, (2) to assess the potential relationship between Cyfra 21-1 and disease stage of the disease in NSCLC, and (3) to evaluate prognostic effect of Cyfra 21-1 in NSCLC. Methods: An immunoradiometric assay of serum Cyfra 21-1 was performed in 161 patients with lung cancers and 71 others with benign lung diseases. The ability of Cyfra 21-1 to detect different histologic subtypes of lung cancer vs benign lung diseases was assessed through receiver operating characteristic (ROC) curves and comparisons with other tumor markers such as carcinoembryonic antigen, neuron-specific enolase, and squamous cell carcinoma antigen. Comparisons of Cyfra 21-1 levels according to histologic subtype and disease stage were done using Kruskal-Wallis test. Independent prognostic value of Cyfra 21-1 was studied with a multivariate analysis of survival (Cox's model). Results: Using a threshold of 3.3 ng/mL for Cyfra 21-1, sensitivity and specificity were, respectively, 0.59 and 0.94 in NSCLC, 0.68 and 0.94 in the subgroup of the squamous cell carcinoma, and 0.19 and 0.94 in small cell lung cancer. Cyfra 21-1 levels were significantly higher in advanced NSCLC than in early-stage disease. All 29 patients with serum concentrations >32 ng/mL had stage IIIB-IV and only one of 14 patients with stage I-II disease had Cyfra 21-1 level >18 ng/mL. In the multivariate analysis of survival, Cyfra 21-1 was an independent prognostic factor along with performance status and disease stage in NSCLC. Conclusions: Cyfra 21-1 is a sensitive and specific tumor marker of NSCLC, especially of squamous cell subtype. It also reflects the extent of the disease and has an independent prognostic role along with performance status and disease stage in NSCLC. Implications: A high level of Cyfra 21-1 in apparently early-stage NSCLC should be an indication for more extensive workup before thoracotomy. The independent prognostic role of Cyfra 21-1 level may be useful in stratifying populations with advanced NSCLC or early-stage resected NSCLC as elevated Cyfra 21-1 levels might identify those patients at high risk for treatment failure.

Published
1995
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